gamma-aminobutyric acid has been researched along with Seizures in 1270 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the comparative safety and adjunctive efficacy of pregabalin and gabapentin in reducing seizure frequency in patients with partial-onset seizures based on prestudy modeling showing superior efficacy for pregabalin." | 9.22 | Adjunctive pregabalin vs gabapentin for focal seizures: Interpretation of comparative outcomes. ( Almas, M; French, J; Friedman, D; Glue, P; Knapp, L; Pitman, V; Posner, HB; Yardi, N, 2016) |
| "The design of this comparative efficacy and safety study of pregabalin and gabapentin as adjunctive treatment in adults with refractory partial-onset seizures was randomized, flexible dose, double blind, and parallel group." | 9.22 | Adjunctive pregabalin vs gabapentin for focal seizures: Interpretation of comparative outcomes. ( Almas, M; French, J; Friedman, D; Glue, P; Knapp, L; Pitman, V; Posner, HB; Yardi, N, 2016) |
| "This study provides Class II evidence that for patients with partial seizures enrolled in this study, pregabalin is not superior to gabapentin in reducing seizure frequency." | 9.22 | Adjunctive pregabalin vs gabapentin for focal seizures: Interpretation of comparative outcomes. ( Almas, M; French, J; Friedman, D; Glue, P; Knapp, L; Pitman, V; Posner, HB; Yardi, N, 2016) |
| "To evaluate the long-term efficacy of gabapentin (GBP) and usefulness of measurement of the blood level for the observation of patients that have partial seizures." | 9.19 | The efficacy of gabapentin in children of partial seizures and the blood levels. ( Ishii, M; Iwasaki, T; Nonoda, Y, 2014) |
| "Four-hundred and thirty-four patients with partial seizures were randomized to pregabalin, lamotrigine, or placebo as adjunctive therapy for 17 weeks of double-blind treatment." | 9.14 | A comparison of pregabalin, lamotrigine, and placebo as adjunctive therapy in patients with refractory partial-onset seizures. ( Barrett, J; Baulac, M; Leon, T; O'Brien, TJ; Whalen, E, 2010) |
| "During phase I, there was a nonsignificant trend toward a greater reduction in seizures with pregabalin versus placebo and lamotrigine." | 9.14 | A comparison of pregabalin, lamotrigine, and placebo as adjunctive therapy in patients with refractory partial-onset seizures. ( Barrett, J; Baulac, M; Leon, T; O'Brien, TJ; Whalen, E, 2010) |
| "Pregabalin was demonstrated to be noninferior to lamotrigine in the treatment of refractory partial seizures." | 9.14 | A comparison of pregabalin, lamotrigine, and placebo as adjunctive therapy in patients with refractory partial-onset seizures. ( Barrett, J; Baulac, M; Leon, T; O'Brien, TJ; Whalen, E, 2010) |
| "This study assessed the comparative efficacy of pregabalin for refractory partial seizures." | 9.14 | A comparison of pregabalin, lamotrigine, and placebo as adjunctive therapy in patients with refractory partial-onset seizures. ( Barrett, J; Baulac, M; Leon, T; O'Brien, TJ; Whalen, E, 2010) |
| "To evaluate bodyweight gain during pregabalin therapy for epilepsy and the utility of a short counseling program to prevent this side effect." | 9.13 | Bodyweight gain under pregabalin therapy in epilepsy: mitigation by counseling patients? ( Elger, CE; Hoffmann, JM; Hoppe, C; Rademacher, M; Schmidt, D, 2008) |
| "Randomized controlled trial on the effects of extended versus standard patient counseling on the risk of bodyweight gain with 3- and 6-month follow-up including a consecutive sample of adult outpatients with epilepsy eligible for pregabalin add-on treatment (N=98)." | 9.13 | Bodyweight gain under pregabalin therapy in epilepsy: mitigation by counseling patients? ( Elger, CE; Hoffmann, JM; Hoppe, C; Rademacher, M; Schmidt, D, 2008) |
| "Pregabalin treatment is associated with a high risk for bodyweight gain which in part depends on total anticonvulsant drug load." | 9.13 | Bodyweight gain under pregabalin therapy in epilepsy: mitigation by counseling patients? ( Elger, CE; Hoffmann, JM; Hoppe, C; Rademacher, M; Schmidt, D, 2008) |
| " At our institution, new-onset seizures in children on chemotherapy are treated with gabapentin, a nonhepatic enzyme inducer." | 9.11 | Gabapentin to control seizures in children undergoing cancer treatment. ( Hunt, DL; Khan, RB; Thompson, SJ, 2004) |
| "Studies in patients with epilepsy undergoing telemetry evaluation for surgery have suggested that discontinuation of carbamazepine (CBZ) is associated with increased seizures." | 9.09 | Increased seizures after discontinuing carbamazepine: results from the gabapentin monotherapy trial. ( DeToledo, JC; Garofalo, EA; Greiner, M; Lowe, MR; Ramsay, RE, 2000) |
| "The effect of gabapentin on cognition and quality of life (QoL) in patients with epilepsy was investigated using a controlled pre- and post-treatment design." | 9.08 | Effects of gabapentin on cognition and quality of life in patients with epilepsy. ( Emmers, E; Mortimore, C; Trimble, M, 1998) |
| "Gabapentin is widely approved as add-on therapy for epilepsy treatment for partial seizures with and without secondary generalization." | 9.08 | A double-blind trial of gabapentin monotherapy for newly diagnosed partial seizures. International Gabapentin Monotherapy Study Group 945-77. ( Alexander, J; Anhut, H; Chadwick, DW; Garofalo, EA; Greiner, MJ; Murray, GH; Pierce, MW, 1998) |
| "The results of a multicenter, double-blind, placebo-controlled clinical trial of the efficacy and safety of progabide (PGB) in the treatment of partial seizures are presented." | 9.06 | A controlled study of progabide in partial seizures: methodology and results. ( Bowman, T; Cloyd, J; Crosby, C; Dreifuss, FE; Graves, N; Jacobs, M; Leppik, IE; Porter, R; Santilli, N; Stackman, J, 1987) |
| "To determine whether pregabalin reduces SGTC seizures in clinically refractory epilepsy." | 8.84 | Reduction of secondarily generalized tonic-clonic (SGTC) seizures with pregabalin. ( Briggs, DE; French, JA; Lee, CM; Spiegel, K, 2008) |
| " A significant reduction in absolute SGTC seizures from baseline was observed in patients receiving pregabalin 600 mg/day (treatment RRatio, -33 versus placebo, -3." | 8.84 | Reduction of secondarily generalized tonic-clonic (SGTC) seizures with pregabalin. ( Briggs, DE; French, JA; Lee, CM; Spiegel, K, 2008) |
| "As adjunctive therapy, pregabalin 600 mg/day is effective in reducing the absolute frequency of SGTC seizures in patients with refractory partial epilepsy, but not secondary generalization." | 8.84 | Reduction of secondarily generalized tonic-clonic (SGTC) seizures with pregabalin. ( Briggs, DE; French, JA; Lee, CM; Spiegel, K, 2008) |
| "Pyridoxine-dependent seizures have been recognised for 40 years, but the clinical and biochemical features are still not understood." | 8.82 | Pyridoxine-dependent seizures: a clinical and biochemical conundrum. ( Baxter, P, 2003) |
| " Hence, the methanol extract was further explored for its anticonvulsant potential in pentylenetetrazole (PTZ) induced acute seizures in mice." | 8.31 | Anticonvulsant potential of Grewia tiliaefolia in pentylenetetrazole induced epilepsy: insights from in vivo and in silico studies. ( Arora, S; Kaur, S; Kumar, N; Rajput, A; Sharma, P; Singh Bedi, PM; Singh, B; Singh, H; Singh, S; Singh, T, 2023) |
| "The goal of our study was to examine the long-term effect of vigabatrin (VGB), a γ-aminobutyric acid aminotransferase (GABA-AT) inhibitor on clonazepam (CLO), ethosuximide (ETX) and valproate (VPA) anticonvulsive activity against pentylenetetrazole (PTZ)-induced seizures in mice." | 7.96 | Long-term vigabatrin treatment modifies pentylenetetrazole-induced seizures in mice: focused on GABA brain concentration. ( Czuczwar, SJ; Krzyżanowski, M; Świąder, K; Świąder, MJ; Wróbel, A; Zakrocka, I; Łuszczki, JJ, 2020) |
| "In a large cohort of older patients with a seizure disorder, pregabalin was not associated with an increased risk of heart failure relative to gabapentin." | 7.85 | Pregabalin and heart failure: A population-based study. ( Antoniou, T; Gomes, T; Ho, JM; Juurlink, DN; Luo, J; Macdonald, EM; Mamdani, MM, 2017) |
| "The anticonvulsant pregabalin is increasingly prescribed for pain, seizures, and psychiatric disorders." | 7.85 | Pregabalin and heart failure: A population-based study. ( Antoniou, T; Gomes, T; Ho, JM; Juurlink, DN; Luo, J; Macdonald, EM; Mamdani, MM, 2017) |
| "An 8-year-old girl treated at our facility for superrefractory status epilepticus was found to have a low pyridoxine level at 5 μg/L." | 7.81 | Pyridoxine deficiency in adult patients with status epilepticus. ( Dave, HN; Eugene Ramsay, R; Irland, M; Khan, F; Sabharwal, V, 2015) |
| "These data indicate that MSCs were superior to gabapentin in ameliorating PTZ-induced epileptogenesis and verified the potential use of MSCs in seizure control, motor and cognitive impairments, oxidative stress, and the impairing GABA level in experimentally induced epilepsy." | 7.80 | Effects of intravenous human umbilical cord blood mesenchymal stem cell therapy versus gabapentin in pentylenetetrazole-induced chronic epilepsy in rats. ( Essawy, SS; Ewais, MM; Mohammed, AS; Tawfik, MK, 2014) |
| "Latrunculin A microperfusion of the hippocampus induces acute epileptic seizures and long-term biochemical changes leading to spontaneous seizures." | 7.80 | Effects of eslicarbazepine acetate on acute and chronic latrunculin A-induced seizures and extracellular amino acid levels in the mouse hippocampus. ( Loureiro, AI; Sierra-Marcuño, G; Sierra-Paredes, G; Soares-da-Silva, P; Wright, LC, 2014) |
| "Oral administration of ESL (100 mg/kg), previous to latrunculin A microperfusion, completely prevented acute latrunculin A-induced seizures as well as chronic seizures and all EEG chronic signs of paroxysmal activity." | 7.80 | Effects of eslicarbazepine acetate on acute and chronic latrunculin A-induced seizures and extracellular amino acid levels in the mouse hippocampus. ( Loureiro, AI; Sierra-Marcuño, G; Sierra-Paredes, G; Soares-da-Silva, P; Wright, LC, 2014) |
| "ESL treatment prevented acute latrunculin A-induced seizures as well as chronic seizures and all EEG chronic signs of paroxysmal activity, supporting a possible anti-epileptogenic effect of ESL in mice." | 7.80 | Effects of eslicarbazepine acetate on acute and chronic latrunculin A-induced seizures and extracellular amino acid levels in the mouse hippocampus. ( Loureiro, AI; Sierra-Marcuño, G; Sierra-Paredes, G; Soares-da-Silva, P; Wright, LC, 2014) |
| " While seizures are usually intractable to medication in tuberous sclerosis complex (TSC), a common genetic cause of epilepsy, vigabatrin appears to have unique efficacy for epilepsy in TSC." | 7.79 | Vigabatrin inhibits seizures and mTOR pathway activation in a mouse model of tuberous sclerosis complex. ( McDaniel, SS; Rensing, NR; Wong, M; Zhang, B, 2013) |
| "Rats were given unilateral kainate injection into hippocampal CA3 region, and the effect of chronic electrographic seizures on extracellular glutamine (GLNECF) was examined in those with low and steady levels of extracellular glutamate (GLUECF)." | 7.79 | Electrographic seizures are significantly reduced by in vivo inhibition of neuronal uptake of extracellular glutamine in rat hippocampus. ( Kanamori, K; Ross, BD, 2013) |
| "The lithium-pilocarpine model of epilepsy reproduces in rodents several features of human temporal lobe epilepsy, by inducing an acute status epilepticus (SE) followed by a latency period." | 7.79 | Gabapentin administration reduces reactive gliosis and neurodegeneration after pilocarpine-induced status epilepticus. ( Angelo, MF; Lukin, J; Ramos, AJ; Rossi, AR; Villarreal, A, 2013) |
| "To determine the efficacy of pregabalin (PGB) in treatment of frequent nonconvulsive seizures (NCS) and nonconvulsive status epilepticus (NCSE) in critically ill patients." | 7.79 | Use of pregabalin for nonconvulsive seizures and nonconvulsive status epilepticus. ( Doreswamy, M; Husain, AM; Swisher, CB, 2013) |
| "Pregabalin may be safe option for add-on treatment for nonconvulsive seizures in critically ill patients when conventional therapy fails." | 7.79 | Use of pregabalin for nonconvulsive seizures and nonconvulsive status epilepticus. ( Doreswamy, M; Husain, AM; Swisher, CB, 2013) |
| " We here investigated for the first time the effect of L-theanine intake on seizure susceptibility using acute pilocarpine and pentylenetetrazol (PTZ) mouse models for studying, respectively, limbic seizures or primarily generalized seizures." | 7.79 | L-Theanine intake increases threshold for limbic seizures but decreases threshold for generalized seizures. ( Loyens, E; Massie, A; Michotte, Y; Schallier, A; Smolders, I; Van Liefferinge, J; Vermoesen, K, 2013) |
| "Glutaric acidemia type I (GA-I) is an inherited metabolic disease characterized by accumulation of glutaric acid (GA) and seizures." | 7.78 | m-Trifluoromethyl diphenyl diselenide attenuates glutaric acid-induced seizures and oxidative stress in rat pups: involvement of the γ-aminobutyric acidergic system. ( Brüning, CA; Fighera, MR; Gai, BM; Magni, DV; Nogueira, CW; Quines, CB; Rosa, SG, 2012) |
| "This study was aimed at investigating the anticonvulsant activity of lipoic acid (LA) against pilocarpine-induced seizures as well as the effects of this metabolic antioxidant on the hippocampal extracellular concentrations of amino acid neurotransmitters glutamate, aspartate, glycine and glutamate and γ-aminobutyric acid (GABA)." | 7.77 | Lipoic acid alters amino acid neurotransmitters content in rat hippocampus after pilocarpine-induced seizures. ( de Freitas, RM; de Oliveira Silva, F; Jordán, J; Saldanha, GB, 2011) |
| " Therefore, we tested whether LY293558 is effective against soman-induced seizures and neuropathology, when administered 1 h after soman exposure, in rats." | 7.77 | The GluK1 (GluR5) Kainate/{alpha}-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist LY293558 reduces soman-induced seizures and neuropathology. ( Apland, JP; Aroniadou-Anderjaska, V; Braga, MF; Figueiredo, TH; Qashu, F; Souza, AP, 2011) |
| "Pregabalin (PGB) was licensed in Europe as an add-on antiepileptic drug (AED) for the treatment of partial-onset seizures in 2004." | 7.77 | Adjunctive pregabalin for uncontrolled partial-onset seizures: findings from a prospective audit. ( Brodie, MJ; Kelly, K; Leach, V; Parker, P; Stephen, LJ; Wilson, EA, 2011) |
| "The present study was focused to characterize the effects of intrahippocampal application of R-verapamil, a P-glycoprotein blocker, and High Frequency Electrical Stimulation (HFS) at 130 Hz, on seizure susceptibility and extracellular concentrations of glutamate and γ-aminobutyric acid (GABA) in hippocampus of kindled rats with drug-resistant seizures." | 7.77 | Effects of high frequency electrical stimulation and R-verapamil on seizure susceptibility and glutamate and GABA release in a model of phenytoin-resistant seizures. ( Luna-Munguia, H; Orozco-Suarez, S; Rocha, L, 2011) |
| "To evaluate the effects of high-frequency electrical stimulation (HFS) in both ventral hippocampi, alone and combined with a subeffective dose of antiepileptic drugs, during the status epilepticus (SE) induced by lithium-pilocarpine (LP)." | 7.76 | Antiepileptic drugs combined with high-frequency electrical stimulation in the ventral hippocampus modify pilocarpine-induced status epilepticus in rats. ( Alcantara-Gonzalez, D; Cuellar-Herrera, M; Neri-Bazan, L; Peña, F; Rocha, L, 2010) |
| " Inhibitory gamma-aminobutyric acid (GABA) and excitatory N-methyl-D-aspartate (NMDA) systems play a role in the effect of stimulants in the genesis of epileptic seizures." | 7.76 | Effect of cross-fostering on seizures in adult male offspring of methamphetamine-treated rat mothers. ( Bernásková, K; Hrubá, L; Matejovská, I; Rokyta, R; Slamberová, R, 2010) |
| "Here we describe our experience with pregabalin (PGB); its effectiveness was retrospectively studied in nine consecutive patients with primary brain tumors and seizures." | 7.75 | Pregabalin in patients with primary brain tumors and seizures: a preliminary observation. ( Novy, J; Rossetti, AO; Stupp, R, 2009) |
| "Methylmalonic acid (MMA) is an endogenous convulsing compound that accumulates in methylmalonic acidemia, an inborn error of the metabolism characterized by severe neurological dysfunction, including seizures." | 7.74 | Convulsions induced by methylmalonic acid are associated with glutamic acid decarboxylase inhibition in rats: a role for GABA in the seizures presented by methylmalonic acidemic patients? ( Fighera, MR; Garrido-Sanabria, ER; Malfatti, CR; Mello, CF; Muller, AP; Paquetti, L; Perry, ML; Rigo, FK; Schweigert, ID, 2007) |
| "This work was designed to study the influence of drugs during seizures and status epilepticus (SE) induced by pilocarpine and mortality in adult rats." | 7.74 | Study pharmacologic of the GABAergic and glutamatergic drugs on seizures and status epilepticus induced by pilocarpine in adult Wistar rats. ( Assis, MA; Fonteles, MM; Freitas, RL; Freitas, RM; Pereira, MB; Silva, RF; Takahashi, RN, 2007) |
| "The effects of carnosine (beta-alanyl-L-histidine) on amygdaloid-kindled seizures were investigated in rats." | 7.73 | Effects of carnosine on amygdaloid-kindled seizures in Sprague-Dawley rats. ( Chen, Z; Ding, MP; Fan, YY; Jin, CL; Li, Q; Luo, JH; Wu, XH; Yang, LX; Zhang, WP, 2005) |
| "To assess whether there is a change in seizure activity in dogs with refractory epilepsy that are receiving appropriate doses of phenobarbitone and/or potassium bromide, when gabapentin is added to the therapeutic regimen." | 7.73 | Improving seizure control in dogs with refractory epilepsy using gabapentin as an adjunctive agent. ( Govendir, M; Malik, R; Perkins, M, 2005) |
| "Repeated systemic administration of low doses of kainic acid (KA) induces spontaneous convulsive seizures [Hellier JL, Patrylo PR, Buckmaster PS, Dudek FE." | 7.73 | Intranigral transplants of immortalized GABAergic cells decrease the expression of kainic acid-induced seizures in the rat. ( Castillo, CG; Freed, WJ; Giordano, M; Mendoza, S, 2006) |
| " Pilocarpine-induced status epilepticus (SE) was chosen as a model to generate chronic epileptic animals." | 7.73 | Septal GABAergic neurons are selectively vulnerable to pilocarpine-induced status epilepticus and chronic spontaneous seizures. ( Banuelos, C; Castañeda, MT; Colom, LV; Garrido Sanabria, ER; Hernandez, S; Perez-Cordova, MG, 2006) |
| "Limbic seizures were evoked in freely moving rats by intrahippocampal administration of pilocarpine via a microdialysis probe." | 7.73 | Substantia nigra is an anticonvulsant site of action of topiramate in the focal pilocarpine model of limbic seizures. ( Clinckers, R; Ebinger, G; Meurs, A; Michotte, Y; Smolders, I, 2006) |
| "Systemic and intranigral, but not intrahippocampal TPM administration suppressed pilocarpine-induced seizures and neurochemical changes." | 7.73 | Substantia nigra is an anticonvulsant site of action of topiramate in the focal pilocarpine model of limbic seizures. ( Clinckers, R; Ebinger, G; Meurs, A; Michotte, Y; Smolders, I, 2006) |
| "This work was designed to study the influence of drugs during seizures and status epilepticus (SE) induced by pilocarpine and mortality in adult rats." | 7.73 | Effect of gabaergic, glutamatergic, antipsychotic and antidepressant drugs on pilocarpine-induced seizures and status epilepticus. ( Fonteles, MM; Freitas, RM; Sousa, FC; Viana, GS, 2006) |
| " Anticonvulsant effects were evaluated against seizures induced by both 14 mg/kg of 4-aminopyridine and 110 mg/kg of pentylenetetrazole, and neurotoxic effects were evaluated by the rotarod test." | 7.72 | Synergistic interaction between felbamate and lamotrigine against seizures induced by 4-aminopyridine and pentylenetetrazole in mice. ( Armijo, JA; Bravo, J; Cuadrado, A, 2003) |
| " Anticonvulsant effects were evaluated against seizures induced by 14 mg kg(-1) of 4-aminopyridine (4-AP) and by 110 mg kg(-1) of pentylenetetrazole (PTZ), and neurotoxicity by the rotarod test." | 7.72 | Is the interaction between felbamate and valproate against seizures induced by 4-aminopyridine and pentylenetetrazole in mice beneficial? ( Amat, G; Armijo, JA; Cuadrado, A, 2003) |
| " The present study was undertaken to examine the role of ALLO in the anticonvulsant action of fluoxetine against pentylenetetrazole (PTZ)-induced seizures in mice." | 7.72 | Essentiality of central GABAergic neuroactive steroid allopregnanolone for anticonvulsant action of fluoxetine against pentylenetetrazole-induced seizures in mice. ( Chopde, CT; Hirani, K; Mittal, N; Ugale, RR, 2004) |
| " Chronic seizures were induced by amygdalar injection of kainic acid 60 days before death." | 7.71 | Collapse of extracellular glutamate regulation during epileptogenesis: down-regulation and functional failure of glutamate transporter function in rats with chronic seizures induced by kainic acid. ( Doi, T; Kamada, H; Mitsuyama, Y; Nakajima, A; Ohya-Nishiguchi, H; Tokumaru, J; Ueda, Y; Willmore, LJ; Yokoyama, H, 2001) |
| "Several lines of evidence suggest that the binding affinity of glutamate decarboxylase (GAD) to the active form of pyridoxine is low in cases of pyridoxine-dependent seizures (PDS) and that a quantitative imbalance between excitatory (i." | 7.71 | CSF glutamate/GABA concentrations in pyridoxine-dependent seizures: etiology of pyridoxine-dependent seizures and the mechanisms of pyridoxine action in seizure control. ( Goto, T; Matsuo, N; Takahashi, T, 2001) |
| "5 mg/kg) were investigated in focally-evoked pilocarpine-induced (10 mM) seizures in freely moving rats." | 7.71 | 2-chloro-N(6)-cyclopentyladenosine-elicited attenuation of evoked glutamate release is not sufficient to give complete protection against pilocarpine-induced seizures in rats. ( Ebinger, G; Khan, GM; Michotte, Y; Smolders, I, 2001) |
| "The relation between changes in the concentrations of some of the neuroactive extracellular amino acids (glutamate, aspartate, gamma-aminobutyric acid, glycine and taurine) and epileptic seizures has been tested in a new experimental model of seizures induced by picrotoxin microdialysis in chronic freely moving rats." | 7.70 | Extracellular amino acids in the rat hippocampus during picrotoxin threshold seizures in chronic microdialysis experiments. ( Aguilar-Veiga, E; Galán-Valiente, J; Mendez-Alvarez, E; Sierra-Marcuño, G; Sierra-Paredes, G; Soto-Otero, R; Vazquez-Illanes, MD, 1998) |
| "The effects of drugs affecting GABA and glutamic acid receptors on theophylline-induced seizures were investigated in mice." | 7.70 | Gamma-aminobutyric acid and glutamic acid receptors may mediate theophylline-induced seizures in mice. ( Amabeoku, GJ, 1999) |
| " For example, injection of the "indirect" excitotoxin aminooxyacetic acid (AOAA) into the EC of rats causes behavioral seizures and preferential loss of neurons in layer III of the medial EC." | 7.70 | Ultrastructure and immunocytochemical distribution of GABA in layer III of the rat medial entorhinal cortex following aminooxyacetic acid-induced seizures. ( Eid, T; Ottersen, OP; Schwarcz, R, 1999) |
| "The present study was undertaken to gain insights into the mechanism of action of diazepam in focally-evoked pilocarpine-induced seizures by concomitantly assessing the changes produced in the extracellular levels of glutamate, GABA (gamma-aminobutyric acid) and dopamine." | 7.70 | Effects of diazepam on extracellular brain neurotransmitters in pilocarpine-induced seizures in rats. ( Ebinger, G; Khan, GM; Lindekens, H; Manil, J; Michotte, Y; Smolders, I, 1999) |
| "The effects of GABAmimetic drugs on inhibition of amygdaloid kindled seizures induced by clobenpropit were investigated to clarify the relationship between histaminergic and GABAergic systems in seizures." | 7.70 | Participation of GABAergic and histaminergic systems in inhibiting amygdaloid kindled seizures. ( Chen, Z; Fujii, Y; Ishizawa, K; Kamei, C; Okuma, C; Sugimoto, Y, 2000) |
| " Seizures were evoked with pilocarpine (400 mg/kg, i." | 7.70 | The effect of CGP-40116 on pilocarpine evoked seizures in mice exposed to transient episode of brain ischemia. ( Czuczwar, SJ; Kleinrok, Z; Rejdak, K; Rejdak, R; Sieklucka-Dziuba, M; Stelmasiak, Z, 2000) |
| "The purpose of the present investigation was to determine whether the sensitivity to systemic toxic effects of cocaine is altered in genetically epilepsy-prone rats (GEPRs)." | 7.70 | Phenotypic expression of the systemic toxicity of cocaine in genetically epilepsy-prone rats. ( Heavner, JE; Kao, YJ; Kaye, AD; Reigel, CE; Shi, B, 2000) |
| "Infusion of the K(+) channel blocker 4-aminopyridine in the hippocampus induces the release of glutamate, as well as seizures and neurodegeneration." | 7.70 | Seizures and neurodegeneration induced by 4-aminopyridine in rat hippocampus in vivo: role of glutamate- and GABA-mediated neurotransmission and of ion channels. ( Peña, F; Tapia, R, 2000) |
| " The effects of some GABAergic and dopaminergic agents on pyrimethamine-induced tonic seizures were investigated in mice." | 7.69 | GABAergic and dopaminergic systems may be involved in seizures induced by pyrimethamine in mice. ( Amabeoku, G; Chikuni, O, 1994) |
| "Pyridoxine-dependent seizures are a disorder of GABA metabolism probably due to a defective binding of pyridoxal phosphate coenzyme (PALP) with glutamate decarboxylase (GAD), the rate-limiting enzyme in GABA synthesis." | 7.69 | Pyridoxine-dependent seizures associated with white matter abnormalities. ( Giugliani, R; Jardim, LB; Kliemann, FA; Martins, CE; Pires, RF; Vargas, CR; Vizioli, J, 1994) |
| "An abnormality in the pyridoxal-5'-phosphate (PLP) dependent enzyme, glutamic acid decarboxylase (GAD), which synthesizes gamma-aminobutyric acid (GABA), may underlie the epileptic syndrome of pyridoxine-dependent seizures." | 7.69 | Reduced GABA synthesis in pyridoxine-dependent seizures. ( Gospe, SM; Keen, CL; Olin, KL, 1994) |
| " In the present study, we investigated the effects of GABAergic action on kainic acid (KA)-induced hippocampal seizure in rats with or without hippocampal sclerosis (HS)." | 7.69 | Altered GABAergic effects on kainic acid-induced seizures in the presence of hippocampal sclerosis in rats. ( Araki, T; Goto, I; Kato, M, 1994) |
| "The effects of muscimol, amino-oxyacetic acid (AOAA), diamino-N-butyric acid (DABA), bicuculline, picrotoxin, diazepam and phenobarbitone on the protective effect of clonidine against pentylenetetrazol-induced seizures were studied in mice." | 7.69 | gamma Aminobutyric acid mediation of the anticonvulsant effect of clonidine on pentylenetetrazol-induced seizures in mice. ( Amabeoku, G; Bwakura, E; Chikuni, O, 1994) |
| "There is a reduction of gamma-aminobutyric acid (GABA)-mediated inhibition of the CA1 pyramidal region of the hippocampus during status epilepticus (SE)." | 7.69 | Experimental status epilepticus alters gamma-aminobutyric acid type A receptor function in CA1 pyramidal neurons. ( Coulter, DA; Kapur, J, 1995) |
| "Gabapentin (GBP) is a new antiepileptic drug (AED) approved for adjunctive treatment of complex partial seizures with or without seizures secondarily generalization in adults." | 7.69 | Gabapentin associated with aggressive behavior in pediatric patients with seizures. ( Lo, W; Nahata, MC; Tallian, KB; Tsao, CY, 1996) |
| "To determine whether seizures have age-specific features, we studied the role of gamma-aminobutyric acidB (GABAB) transmission in rats of various ages (9, 15, 30, and 60 postnatal days)." | 7.69 | Age-specific effects of baclofen on pentylenetetrazol-induced seizures in developing rats. ( Moshé, SL; Velísek, L; Velísková, J, 1996) |
| "Several similarities exist between the alterations observed in the chronic pilocarpine model of recurrent seizures in the rat and those found in human temporal lobe epilepsy." | 7.69 | Vulnerability and plasticity of the GABA system in the pilocarpine model of spontaneous recurrent seizures. ( Esclapez, M; Houser, CR, 1996) |
| "Limbic seizures were provoked in freely moving rats by intrahippocampal administration of the muscarinic receptor agonist pilocarpine via a microdialysis probe (10 mM for 40 min at 2 microliters/min)." | 7.69 | Hippocampal and cerebellar extracellular amino acids during pilocarpine-induced seizures in freely moving rats. ( Ebinger, G; Michotte, Y; Smolders, I; Van Belle, K, 1997) |
| "A case of a patient with medically intractable epilepsy, who developed obstructive sleep apnoea (OSA), and an increase in seizure frequency, as a consequence of weight gain following treatment with vigabatrin is described." | 7.69 | Obstructive sleep apnoea following rapid weight gain secondary to treatment with vigabatrin (Sabril). ( Bird, JM; Lambert, MV, 1997) |
| " Pilocarpine administration has been used as an animal model for temporal lobe epilepsy since it produces several morphological and synaptic features in common with human complex partial seizures." | 7.69 | NMDA receptor-mediated pilocarpine-induced seizures: characterization in freely moving rats by microdialysis. ( Ebinger, G; Khan, GM; Manil, J; Michotte, Y; Smolders, I, 1997) |
| "The behavioral and convulsant effects of cefazolin, a beta-lactam derivative, were studied after intraperitoneal administration to DBA/2 mice, a strain genetically susceptible to sound-induced seizures, and Swiss mice." | 7.68 | Quinolones potentiate cefazolin-induced seizures in DBA/2 mice. ( Chimirri, A; De Sarro, A; De Sarro, GB; Grasso, S; Zappalá, M, 1993) |
| "The alpha 2-antagonist, yohimbine has been shown to dose-dependently induce clonic seizures in mice." | 7.68 | Yohimbine-induced seizures involve NMDA and GABAergic transmission. ( Corbett, R; Dunn, RW, 1992) |
| "In an infant with typical pyridoxine-dependent seizures, CSF GABA level, was determined before treatment with pyridoxine." | 7.68 | Disturbance of GABA metabolism in pyridoxine-dependent seizures. ( Bömelburg, T; Grüneberg, M; Kurlemann, G; Palm, DG; Ullrich, K; Ziegler, R, 1992) |
| "Immature rats are more susceptible to clonic seizures induced by aminooxyacetic acid (AOAA) than mature and senile rats." | 7.68 | Age dependency of the susceptibility of rats to aminooxyacetic acid seizures. ( Cavalheiro, EA; Dziki, M; Kleinrok, Z; Parada, J; Turski, W, 1992) |
| " The influence of some GABAergic agents on tonic seizures elicited by chloroquine was investigated in mice." | 7.68 | Involvement of GABAergic mechanisms in chloroquine-induced seizures in mice. ( Amabeoku, G, 1992) |
| "Appearances of pentetrazole-, picrotoxin- and strychnine-induced convulsive seizures in taurine-deficient mice produced by treatment with guanidinoethyl sulfonate (GES), a taurine transport antagonist, were investigated." | 7.68 | [Drug-induced seizures in taurine-deficient mice]. ( Araki, H; Sano, M; Shimada, C; Tanaka, S, 1991) |
| " Metabolic changes associated with kainic acid seizures predominate in the hippocampus, where there are decreases in aspartate (-26%), glutamate (-45%), taurine (-20%), and glutamine (-32%) concentrations and an increase in gamma-aminobutyric acid (GABA) concentration (+ 26%)." | 7.67 | Changes in regional neurotransmitter amino acid levels in rat brain during seizures induced by L-allylglycine, bicuculline, and kainic acid. ( Chapman, AG; Meldrum, BS; Premachandra, M; Westerberg, E, 1984) |
| "The interaction between pentobarbital and other modulators of GABAergic transmission (diazepam, ethanol and progabide) was investigated on maximal electroshock seizures and on the loss of righting reflexes in rats." | 7.67 | Involvement of a GABAergic mechanism in the anticonvulsant effect of pentobarbital against maximal electroshock-induced seizures in rats. ( Rastogi, SK; Ticku, MK, 1985) |
| "Lysine and its metabolic intermediates were studied for their effect on pentylenetetrazol (PTZ)-induced seizures in mice." | 7.67 | Effects of L-lysine and its metabolites on pentylenetetrazol-induced seizures. ( Chang, YF; Myslinski, NR, 1985) |
| "The effects of progabide, a direct gamma-aminobutyric acid (GABA) receptor agonist, on bicuculline-induced seizures have been tested in developing rats, ages 7-28 days, to study the correlation between the antiepileptic effectiveness of this drug and the level of functional maturation of the GABAergic system." | 7.67 | Effects of progabide on bicuculline-induced epileptic seizures in developing rats. ( de Feo, MR; Mecarelli, O; Ricci, GF; Rina, MF, 1988) |
| "The turnover rates and steady-state levels of gamma-aminobutyric acid (GABA) have been determined in 15 brain areas of three sublines of inbred mice differing in their susceptibility to audiogenic seizures: Rb3, which is seizure resistant; Rb2, which develops clonic seizures; and Rb1, which develops tonic-clonic seizures." | 7.67 | Effect of repeated convulsive seizures on brain gamma-aminobutyric acid metabolism in three sublines of mice differing by their response to acoustic stimulations. ( Ciesielski, L; Clement, J; Mandel, P; Simler, S, 1987) |
| "Amino acid concentrations were measured in the cortex, cerebellum and hippocampus of the mouse brain before and during seizures induced by isoniazid (250 mg/kg i." | 7.67 | The specific protective effect of diazepam and valproate against isoniazid-induced seizures is not correlated with increased GABA levels. ( Baltzer, V; Bernasconi, R; Jones, RS; Klein, M; Maître, L; Martin, P; Portet, C; Schmutz, M, 1985) |
| " injection of bicuculline (4, 6 or 8 mg/kg) and were immediately tested for latency to initial myoclonic jerk and clonus." | 7.67 | Coping and seizure susceptibility: control over shock protects against bicuculline-induced seizures. ( Alpern, HP; Drugan, RC; Maier, SF; McIntyre, TD, 1985) |
| "In rabbits, generalized seizures were induced by methoxypyridoxine, and changes in amino acid concentrations of 15 brain regions were investigated before seizure onset and during the course of sustained epileptiform activity." | 7.66 | Alterations in the content of amino acid neurotransmitters before the onset and during the course of methoxypyridoxine-induced seizures in individual rabbit brain regions. ( Haug, P; Nitsch, C; Schmude, B, 1983) |
| "The properties of gamma-aminobutyric acid recognition sites, benzodiazepine binding sites and the effect of exogeneous gamma-aminobutyric acid on benzodiazepine binding were determined in crude membrane fractions prepared from the brains of DBA/2 mice at ages before (8-9 and 17-18 days), during (22-23 and 28-29 days) and after (40-43 days) the age of high susceptibility to audiogenic seizures." | 7.66 | gamma-Aminobutyric acid and benzodiazepine binding sites in audiogenic seizure-susceptible mice. ( Horton, RW; Meldrum, BS; Prestwich, SA, 1982) |
| "The onset of clonic seizures induced by 3-mercaptopropionic acid (MP) was associated with an approximately 200% increase of cAMP and a 70% elevation of cGMP in the mouse cerebral cortex." | 7.66 | Cyclic GMP and cyclic AMP in the cerebral cortex of mice during seizures induced by 3-mercaptopropionic acid: effects of anticonvulsant agents. ( Folbergrová, J, 1980) |
| "Intraperitoneal injection of ethanol (1-2 g/kg) and chlordiazepoxide (2-16 mg/kg) suppressed susceptibility to audiogenically induced, clonic-tonic seizures and antagonized forelimb tremor in rats undergoing ethanol withdrawal, 30 min after treatment." | 7.66 | Differential sensitivity of ethanol withdrawal signs in the rat to gamma-aminobutyric acid (GABA)mimetics: blockade of audiogenic seizures but not forelimb tremors. ( Breese, GR; Frye, GD; McCown, TJ, 1983) |
| "The effect of valproic acid and 10 close analogues (7 branched and 3 non-branched) were studied on the content of gamma-aminobutyric acid (GABA) in brain and on seizures induced by pentylenetetrazol (PTZ) in mice." | 7.66 | The effects of analogues of valproic acid on seizures induced by pentylenetetrazol and GABA content in brain of mice. ( Keane, PE; Mendes, E; Morre, M; Santucci, V; Simiand, J, 1983) |
| "Pyridoxine-dependent seizures occur as a result of an increased requirement of the vitamin within the central nervous system." | 7.66 | Pyridoxine-dependent seizures. ( Crowell, GF; Roach, ES, 1983) |
| " During 1 h of bicuculline-induced seizures (1." | 7.66 | Cortical GABA turnover during bicuculline seizures in rats. ( Chapman, AG; Evans, MC, 1983) |
| "In phase II (6 weeks), patients not yet seizure-free were increased to pregabalin 600mg/day or lamotrigine 400mg/day." | 6.75 | A comparison of pregabalin, lamotrigine, and placebo as adjunctive therapy in patients with refractory partial-onset seizures. ( Barrett, J; Baulac, M; Leon, T; O'Brien, TJ; Whalen, E, 2010) |
| "Epilepsy was symptomatic in 58%, and 74% exhibited associated cognitive deficits." | 6.74 | Pregabalin: preliminary experience in intractable childhood epilepsy. ( Alsaihati, BA; Jan, MM; Zuberi, SA, 2009) |
| "Seizures were mixed in nine (47%), and four (21%) manifested Lennox-Gastaut syndrome." | 6.74 | Pregabalin: preliminary experience in intractable childhood epilepsy. ( Alsaihati, BA; Jan, MM; Zuberi, SA, 2009) |
| "Most (74%) had daily seizures that failed multiple drugs (mean, 5)." | 6.74 | Pregabalin: preliminary experience in intractable childhood epilepsy. ( Alsaihati, BA; Jan, MM; Zuberi, SA, 2009) |
| "Bodyweight gain was correlated with number of anticonvulsant drugs (r=." | 6.73 | Bodyweight gain under pregabalin therapy in epilepsy: mitigation by counseling patients? ( Elger, CE; Hoffmann, JM; Hoppe, C; Rademacher, M; Schmidt, D, 2008) |
| "Seizures were controlled in 49% of 59 children in whom gabapentin was added to other antiepilepsy drugs: 43% of the leukemia group, 53% of the brain tumor group, and 50% of the other tumor group." | 6.71 | Gabapentin to control seizures in children undergoing cancer treatment. ( Hunt, DL; Khan, RB; Thompson, SJ, 2004) |
| "At our institution, new-onset seizures in children on chemotherapy are treated with gabapentin, a nonhepatic enzyme inducer." | 6.71 | Gabapentin to control seizures in children undergoing cancer treatment. ( Hunt, DL; Khan, RB; Thompson, SJ, 2004) |
| "Gabapentin monotherapy was useful and safe for late poststroke ES." | 6.70 | Gabapentin in late-onset poststroke seizures. ( Alvarez-Sabín, J; Codina, A; Molina, CA; Montaner, J; Padró, L; Quintana, M; Rovira, R, 2002) |
| "Stroke is a frequent cause of epileptic seizures (ES) in adults." | 6.70 | Gabapentin in late-onset poststroke seizures. ( Alvarez-Sabín, J; Codina, A; Molina, CA; Montaner, J; Padró, L; Quintana, M; Rovira, R, 2002) |
| "Seventy children with newly diagnosed partial epilepsy were treated with vigabatrin (38 patients) or carbamazepine (32 patients)." | 6.69 | Open comparative long-term study of vigabatrin vs carbamazepine in newly diagnosed partial seizures in children. ( Cardinali, C; Zamponi, N, 1999) |
| "The authors reviewed the occurrence of seizures in patients with epilepsy who had all their antiepileptic medications discontinued during an 8-week period, converted to gabapentin monotherapy, and observed for 26 weeks as part of the gabapentin trial #945-082." | 6.69 | Increased seizures after discontinuing carbamazepine: results from the gabapentin monotherapy trial. ( DeToledo, JC; Garofalo, EA; Greiner, M; Lowe, MR; Ramsay, RE, 2000) |
| "Gabapentin (GBP) is a non-protein-bound gamma amino acid which is not subjected to metabolic degradation in man." | 6.68 | Seizure frequency and CSF parameters in a double-blind placebo controlled trial of gabapentin in patients with intractable complex partial seizures. ( Ben-Menachem, E; Hamberger, A; Hedner, T; Persson, LI; Söderfelt, B, 1995) |
| " The pharmacokinetic parameters of the two enantiomers have been studied after administration of a single oral 125 mg dose of the racemate to six neonates." | 6.68 | Pharmacokinetics of the individual enantiomers of vigabatrin in neonates with uncontrolled seizures. ( Chiron, C; d'Athis, P; Dulac, O; Dumas, C; Olive, G; Pons, G; Rey, E; Vauzelle-Kervroëdan, F, 1996) |
| " During chronic administration (125 mg twice daily over 4 days), there was no evidence of accumulation of either enantiomer." | 6.68 | Pharmacokinetics of the individual enantiomers of vigabatrin in neonates with uncontrolled seizures. ( Chiron, C; d'Athis, P; Dulac, O; Dumas, C; Olive, G; Pons, G; Rey, E; Vauzelle-Kervroëdan, F, 1996) |
| "Patients with partial seizures who failed > or =2 antiepileptic drugs at maximally tolerated doses." | 6.44 | Reduction of secondarily generalized tonic-clonic (SGTC) seizures with pregabalin. ( Briggs, DE; French, JA; Lee, CM; Spiegel, K, 2008) |
| "Sixteen were seizure-free during treatment and not included in the conditional analysis." | 6.44 | Reduction of secondarily generalized tonic-clonic (SGTC) seizures with pregabalin. ( Briggs, DE; French, JA; Lee, CM; Spiegel, K, 2008) |
| "Pyridoxine-dependent seizures have been recognised for 40 years, but the clinical and biochemical features are still not understood." | 6.42 | Pyridoxine-dependent seizures: a clinical and biochemical conundrum. ( Baxter, P, 2003) |
| "Although epilepsy is fundamentally a circuit phenomenon, the most basic manifestation of the hyperexcitability characteristic of epilepsy must be evident at the level of a single neuron." | 6.41 | Epilepsy-associated plasticity in gamma-aminobutyric acid receptor expression, function, and inhibitory synaptic properties. ( Coulter, DA, 2001) |
| "The average number of seizures per month during the previous 3 months before CNB treatment was 19." | 5.91 | Cenobamate and Clobazam Combination as Personalized Medicine in Autoimmune-Associated Epilepsy With Anti-Gad65 Antibodies. ( Aguilar-Castillo, MJ; Cabezudo-García, P; Carreño, M; Ciano-Petersen, NL; Estivill-Torrús, G; García-Martín, G; Gutierrez-Cardo, AL; López-Moreno, Y; Oliver, B; Ortega-Pinazo, J; Ramírez-García, T; Rodríguez-Uranga, JJ; Romero-Godoy, J; Sanchez-Godoy, L; Serrano-Castro, PJ, 2023) |
| "Lacosamide did not increase total or neuronal apoptosis in the neocortex in vitro or in vivo." | 5.72 | Lacosamide decreases neonatal seizures without increasing apoptosis. ( Bassuk, AG; Glykys, J; Langton, RL; Sharma, S; Tiarks, GC, 2022) |
| "Lacosamide reduces neocortical seizure-like activity in neonatal mice in vitro and in vivo without an acute increase in apoptosis." | 5.72 | Lacosamide decreases neonatal seizures without increasing apoptosis. ( Bassuk, AG; Glykys, J; Langton, RL; Sharma, S; Tiarks, GC, 2022) |
| "Absence epilepsy is classified as a childhood generalized epilepsy syndrome with distinctive electroencephalographic patterns." | 5.62 | Vasoactive intestinal peptide (VIP) conducts the neuronal activity during absence seizures: GABA seems to be the main mediator of VIP. ( Arkan, S; Ateş, N; Korkmaz, OT; Öncü-Kaya, EM; Tunçel, N, 2021) |
| "VGB was administered for 3 and 7 days." | 5.56 | Long-term vigabatrin treatment modifies pentylenetetrazole-induced seizures in mice: focused on GABA brain concentration. ( Czuczwar, SJ; Krzyżanowski, M; Świąder, K; Świąder, MJ; Wróbel, A; Zakrocka, I; Łuszczki, JJ, 2020) |
| "Convulsions were evoked by PTZ at its CD97 (99 mg/kg)." | 5.56 | Long-term vigabatrin treatment modifies pentylenetetrazole-induced seizures in mice: focused on GABA brain concentration. ( Czuczwar, SJ; Krzyżanowski, M; Świąder, K; Świąder, MJ; Wróbel, A; Zakrocka, I; Łuszczki, JJ, 2020) |
| "In six-hertz-seizure test the MeCO (25, 50, 100 and 200mg/kg) and AeCO (50, 100, 200, 400 and 800mg/kg) showed significant protection compared to control group, and MeCO was more potent than AeCO." | 5.46 | Ameliorative potential of Colebrookea oppositifolia methanolic root extract against experimental models of epilepsy: Possible role of GABA mediated mechanism. ( Prasad, NBL; Venkataranganna, MV; Viswanatha, GL, 2017) |
| "In this study, we evaluated the dose-response efficacy of levetiracetam (12." | 5.46 | Combination therapy of levetiracetam and gabapentin against nonconvulsive seizures induced by penetrating traumatic brain injury. ( Cao, Y; Liao, Z; Lu, XM; Mountney, A; Shear, DA; Tortella, FC, 2017) |
| " However, the two drugs manifested different dose-response profiles." | 5.46 | Combination therapy of levetiracetam and gabapentin against nonconvulsive seizures induced by penetrating traumatic brain injury. ( Cao, Y; Liao, Z; Lu, XM; Mountney, A; Shear, DA; Tortella, FC, 2017) |
| "Posttraumatic seizures are a medical problem affecting patients with traumatic brain injury." | 5.46 | Combination therapy of levetiracetam and gabapentin against nonconvulsive seizures induced by penetrating traumatic brain injury. ( Cao, Y; Liao, Z; Lu, XM; Mountney, A; Shear, DA; Tortella, FC, 2017) |
| "Seizures were detected by continuous electroencephalogram (EEG) monitoring for 72 hours postinjury." | 5.46 | Combination therapy of levetiracetam and gabapentin against nonconvulsive seizures induced by penetrating traumatic brain injury. ( Cao, Y; Liao, Z; Lu, XM; Mountney, A; Shear, DA; Tortella, FC, 2017) |
| "Levetiracetam attenuated seizure activity in a dose-dependent fashion, whereas the beneficial effects of gabapentin plateaued across the three highest doses tested." | 5.46 | Combination therapy of levetiracetam and gabapentin against nonconvulsive seizures induced by penetrating traumatic brain injury. ( Cao, Y; Liao, Z; Lu, XM; Mountney, A; Shear, DA; Tortella, FC, 2017) |
| "Gabapentin is an antiepileptic that is used to manage neuropathic pain." | 5.46 | Gabapentin-Induced Bullous Pemphigoid. ( Dufresne, F; Flamm, A; Sachdev, S, 2017) |
| "Bullous pemphigoid is an autoimmune blistering dermatosis with separation of the epidermis from the dermis." | 5.46 | Gabapentin-Induced Bullous Pemphigoid. ( Dufresne, F; Flamm, A; Sachdev, S, 2017) |
| "Mirtazapine was more effective than desipramine in restoring somatosensory cortex thickness by fully rescuing pyramidal neurons dendritic arborization and spine density." | 5.43 | Pharmacological treatment with mirtazapine rescues cortical atrophy and respiratory deficits in MeCP2 null mice. ( Baj, G; Bernareggi, A; Bittolo, T; Deiana, C; Ferrazzo, S; Raminelli, CA; Tongiorgi, E; Vaghi, V, 2016) |
| "A selective pyridoxine deficiency was seen in 94% of patients with status epilepticus (compared to 39." | 5.42 | Pyridoxine deficiency in adult patients with status epilepticus. ( Dave, HN; Eugene Ramsay, R; Irland, M; Khan, F; Sabharwal, V, 2015) |
| "Vigabatrin is an inhibitor of γ-aminobutyric acid transaminase." | 5.40 | Population pharmacokinetics analysis of vigabatrin in adults and children with epilepsy and children with infantile spasms. ( Karim, A; Kowalski, KG; Nielsen, JC; Patel, M; Tolbert, D; Wesche, DL, 2014) |
| "Vigabatrin pharmacokinetic data from six randomized controlled clinical trials and one open-label study were analyzed using nonlinear mixed-effects modeling." | 5.40 | Population pharmacokinetics analysis of vigabatrin in adults and children with epilepsy and children with infantile spasms. ( Karim, A; Kowalski, KG; Nielsen, JC; Patel, M; Tolbert, D; Wesche, DL, 2014) |
| " Covariate analysis indicated that age, creatinine clearance (CLCR), and body weight were important predictors of vigabatrin pharmacokinetic parameters." | 5.40 | Population pharmacokinetics analysis of vigabatrin in adults and children with epilepsy and children with infantile spasms. ( Karim, A; Kowalski, KG; Nielsen, JC; Patel, M; Tolbert, D; Wesche, DL, 2014) |
| "The model adequately described vigabatrin pharmacokinetic and enabled predictions of systemic exposures in pediatric patients 1-12 months of age." | 5.40 | Population pharmacokinetics analysis of vigabatrin in adults and children with epilepsy and children with infantile spasms. ( Karim, A; Kowalski, KG; Nielsen, JC; Patel, M; Tolbert, D; Wesche, DL, 2014) |
| "1 %) and relative bioavailability (F) (26." | 5.40 | Population pharmacokinetics analysis of vigabatrin in adults and children with epilepsy and children with infantile spasms. ( Karim, A; Kowalski, KG; Nielsen, JC; Patel, M; Tolbert, D; Wesche, DL, 2014) |
| "While seizures are usually intractable to medication in tuberous sclerosis complex (TSC), a common genetic cause of epilepsy, vigabatrin appears to have unique efficacy for epilepsy in TSC." | 5.39 | Vigabatrin inhibits seizures and mTOR pathway activation in a mouse model of tuberous sclerosis complex. ( McDaniel, SS; Rensing, NR; Wong, M; Zhang, B, 2013) |
| "Although antiseizure medication is the first-line treatment for epilepsy, currently available medications are ineffective in a significant percentage of patients and have not clearly been demonstrated to have disease-specific effects for epilepsy." | 5.39 | Vigabatrin inhibits seizures and mTOR pathway activation in a mouse model of tuberous sclerosis complex. ( McDaniel, SS; Rensing, NR; Wong, M; Zhang, B, 2013) |
| "The frequency of electrographic seizures during uptake inhibition was reduced to 35±7% (n=7) of the frequency in pre-perfusion period, and returned to 88±9% in the post-perfusion period." | 5.39 | Electrographic seizures are significantly reduced by in vivo inhibition of neuronal uptake of extracellular glutamine in rat hippocampus. ( Kanamori, K; Ross, BD, 2013) |
| "Tonic hind limb extension (seizure activity) was evoked in adult male albino Swiss mice by a current (sine-wave, 25 mA, 500 V, 50 Hz, 0." | 5.39 | Effects of WIN 55,212-2 mesylate on the anticonvulsant action of lamotrigine, oxcarbazepine, pregabalin and topiramate against maximal electroshock-induced seizures in mice. ( Czuczwar, SJ; Florek-Luszczki, M; Karwan, S; Luszczki, JJ; Wlaz, A, 2013) |
| "Gabapentin treatment was able to reduce reactive gliosis, decrease neuronal loss and normalize PSA-NCAM staining in hippocampal CA-1." | 5.39 | Gabapentin administration reduces reactive gliosis and neurodegeneration after pilocarpine-induced status epilepticus. ( Angelo, MF; Lukin, J; Ramos, AJ; Rossi, AR; Villarreal, A, 2013) |
| "Once SE was achieved, seizures were stopped with 20 mg/kg diazepam." | 5.39 | Gabapentin administration reduces reactive gliosis and neurodegeneration after pilocarpine-induced status epilepticus. ( Angelo, MF; Lukin, J; Ramos, AJ; Rossi, AR; Villarreal, A, 2013) |
| "LY293558 stopped seizures induced by soman and reduced the total duration of SE, monitored by electroencephalographic recordings within a 24 h-period after exposure." | 5.37 | The GluK1 (GluR5) Kainate/{alpha}-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist LY293558 reduces soman-induced seizures and neuropathology. ( Apland, JP; Aroniadou-Anderjaska, V; Braga, MF; Figueiredo, TH; Qashu, F; Souza, AP, 2011) |
| "Of the 135 patients, 14 (10." | 5.37 | Adjunctive pregabalin for uncontrolled partial-onset seizures: findings from a prospective audit. ( Brodie, MJ; Kelly, K; Leach, V; Parker, P; Stephen, LJ; Wilson, EA, 2011) |
| "To evaluate the effects of high-frequency electrical stimulation (HFS) in both ventral hippocampi, alone and combined with a subeffective dose of antiepileptic drugs, during the status epilepticus (SE) induced by lithium-pilocarpine (LP)." | 5.36 | Antiepileptic drugs combined with high-frequency electrical stimulation in the ventral hippocampus modify pilocarpine-induced status epilepticus in rats. ( Alcantara-Gonzalez, D; Cuellar-Herrera, M; Neri-Bazan, L; Peña, F; Rocha, L, 2010) |
| " One minute following pilocarpine injection, HFS (pulses of 60 mus width at 130 Hz at subthreshold intensities and applied during 3 h) was applied alone or combined with subeffective doses of antiepileptic drugs." | 5.36 | Antiepileptic drugs combined with high-frequency electrical stimulation in the ventral hippocampus modify pilocarpine-induced status epilepticus in rats. ( Alcantara-Gonzalez, D; Cuellar-Herrera, M; Neri-Bazan, L; Peña, F; Rocha, L, 2010) |
| " This effect was not evident when HFS was combined with phenytoin (33." | 5.36 | Antiepileptic drugs combined with high-frequency electrical stimulation in the ventral hippocampus modify pilocarpine-induced status epilepticus in rats. ( Alcantara-Gonzalez, D; Cuellar-Herrera, M; Neri-Bazan, L; Peña, F; Rocha, L, 2010) |
| " Daily median dosage was 300 mg." | 5.35 | Pregabalin in patients with primary brain tumors and seizures: a preliminary observation. ( Novy, J; Rossetti, AO; Stupp, R, 2009) |
| "Patients with brain tumors and seizures should be treated with non-enzyme-inducing antiepileptic drugs (AED)." | 5.35 | Pregabalin in patients with primary brain tumors and seizures: a preliminary observation. ( Novy, J; Rossetti, AO; Stupp, R, 2009) |
| "All subjects experienced at least a 50% seizure reduction, six were seizure-free." | 5.35 | Pregabalin in patients with primary brain tumors and seizures: a preliminary observation. ( Novy, J; Rossetti, AO; Stupp, R, 2009) |
| "Acute seizure activity was behaviorally scored and hemispheric brain atrophy measured." | 5.35 | Gabapentin neuroprotection and seizure suppression in immature mouse brain ischemia. ( Comi, AM; Johnston, MV; Kadam, SD; Mulholland, JD; Traa, BS, 2008) |
| "Methylmalonic acid (MMA) is an endogenous convulsing compound that accumulates in methylmalonic acidemia, an inborn error of the metabolism characterized by severe neurological dysfunction, including seizures." | 5.34 | Convulsions induced by methylmalonic acid are associated with glutamic acid decarboxylase inhibition in rats: a role for GABA in the seizures presented by methylmalonic acidemic patients? ( Fighera, MR; Garrido-Sanabria, ER; Malfatti, CR; Mello, CF; Muller, AP; Paquetti, L; Perry, ML; Rigo, FK; Schweigert, ID, 2007) |
| "The mechanisms by which MMA causes seizures involves the activation of the N-methyl-D-aspartate (NMDA) receptors, but whether GABAergic mechanisms are involved in the convulsions induced by MMA is not known." | 5.34 | Convulsions induced by methylmalonic acid are associated with glutamic acid decarboxylase inhibition in rats: a role for GABA in the seizures presented by methylmalonic acidemic patients? ( Fighera, MR; Garrido-Sanabria, ER; Malfatti, CR; Mello, CF; Muller, AP; Paquetti, L; Perry, ML; Rigo, FK; Schweigert, ID, 2007) |
| "Convulsions were confirmed by electroencephalographic recording in a subset of animals." | 5.34 | Convulsions induced by methylmalonic acid are associated with glutamic acid decarboxylase inhibition in rats: a role for GABA in the seizures presented by methylmalonic acidemic patients? ( Fighera, MR; Garrido-Sanabria, ER; Malfatti, CR; Mello, CF; Muller, AP; Paquetti, L; Perry, ML; Rigo, FK; Schweigert, ID, 2007) |
| "Imperatorin at lower doses of 20 and 30 mg/kg had no significant effect on the anticonvulsant activities of conventional antiepileptic drugs in the mouse maximal electroshock seizure model." | 5.34 | Imperatorin enhances the protective activity of conventional antiepileptic drugs against maximal electroshock-induced seizures in mice. ( Czuczwar, SJ; Glowniak, K; Luszczki, JJ, 2007) |
| "Mefloquine dose dependently induced tonic seizures in mice." | 5.33 | Gamma-aminobutyric acid and mefloquine-induced seizures in mice. ( Amabeoku, GJ; Farmer, CC, 2005) |
| "Patients were stabilised using phenobarbitone and/or potassium bromide to produce tolerable therapeutic serum concentrations and dosed additionally with gabapentin at 35 to 50 mg/kg/d (divided twice or three times daily) for 4 months." | 5.33 | Improving seizure control in dogs with refractory epilepsy using gabapentin as an adjunctive agent. ( Govendir, M; Malik, R; Perkins, M, 2005) |
| "To assess whether there is a change in seizure activity in dogs with refractory epilepsy that are receiving appropriate doses of phenobarbitone and/or potassium bromide, when gabapentin is added to the therapeutic regimen." | 5.33 | Improving seizure control in dogs with refractory epilepsy using gabapentin as an adjunctive agent. ( Govendir, M; Malik, R; Perkins, M, 2005) |
| "Owners recorded seizure activity and side effects during this period in a standardised diary." | 5.33 | Improving seizure control in dogs with refractory epilepsy using gabapentin as an adjunctive agent. ( Govendir, M; Malik, R; Perkins, M, 2005) |
| "In some dogs, seizures were prevented completely, while in others there was an increase in interictal period." | 5.33 | Improving seizure control in dogs with refractory epilepsy using gabapentin as an adjunctive agent. ( Govendir, M; Malik, R; Perkins, M, 2005) |
| "In vivo, it potently prevents seizures, pain-related behaviors and has anxiolytic-like activity in rodent models." | 5.33 | Activity profile of pregabalin in rodent models of epilepsy and ataxia. ( Bertram, E; Kinsora, JJ; Radulovic, LL; Serpa, KA; Taylor, CP; Vartanian, MG; Vergnes, M, 2006) |
| "Flurothyl was used to induce multiple recurrent seizures in rat pups during the first postnatal days." | 5.33 | Selective impairment of GABAergic synaptic transmission in the flurothyl model of neonatal seizures. ( Holmes, GL; Isaev, D; Isaeva, E; Khazipov, R, 2006) |
| "Neonatal seizures can result in long-term adverse consequences including alteration of seizure susceptibility and impairment in spatial memory." | 5.33 | Selective impairment of GABAergic synaptic transmission in the flurothyl model of neonatal seizures. ( Holmes, GL; Isaev, D; Isaeva, E; Khazipov, R, 2006) |
| "Recurrent spontaneous motor seizures after repeated low-dose systemic treatment with kainate: assessment of a rat model of temporal lobe epilepsy." | 5.33 | Intranigral transplants of immortalized GABAergic cells decrease the expression of kainic acid-induced seizures in the rat. ( Castillo, CG; Freed, WJ; Giordano, M; Mendoza, S, 2006) |
| "Seizures were detected by continuous electroencephalographic monitoring for 24 h following permanent middle cerebral artery occlusion (MCAo)." | 5.33 | Evaluation of gabapentin and ethosuximide for treatment of acute nonconvulsive seizures following ischemic brain injury in rats. ( Bautista, CC; Chen, RW; Dave, JR; Hartings, JA; Lu, XC; Tortella, FC; Williams, AJ, 2006) |
| "Acute seizures following brain injury have been associated with a worsening of patient outcome, but they are often undiagnosed and untreated when they occur without motor convulsions." | 5.33 | Evaluation of gabapentin and ethosuximide for treatment of acute nonconvulsive seizures following ischemic brain injury in rats. ( Bautista, CC; Chen, RW; Dave, JR; Hartings, JA; Lu, XC; Tortella, FC; Williams, AJ, 2006) |
| "Limbic seizures were evoked in freely moving rats by intrahippocampal administration of pilocarpine via a microdialysis probe." | 5.33 | Substantia nigra is an anticonvulsant site of action of topiramate in the focal pilocarpine model of limbic seizures. ( Clinckers, R; Ebinger, G; Meurs, A; Michotte, Y; Smolders, I, 2006) |
| "Gastrodin reduced the seizure score in the treated group, although the immunoreactivities of GABA synthetic enzymes and GABA transporters were unaltered in gastrodin-treated animals." | 5.32 | Gastrodin decreases immunoreactivities of gamma-aminobutyric acid shunt enzymes in the hippocampus of seizure-sensitive gerbils. ( An, SJ; Baek, NI; Choi, SY; Hwang, IK; Jung, SJ; Kang, TC; Kim, SK; Kwon, OS; Lee, HY; Park, SK; Won, MH, 2003) |
| "Gabapentin was also effective against two other bs mutants, bangsenseless(1) and slamdance(iso7." | 5.32 | Treatment with the antiepileptic drugs phenytoin and gabapentin ameliorates seizure and paralysis of Drosophila bang-sensitive mutants. ( Feeney, L; Jacobs, B; McKeever, C; Reynolds, ER; Rojahn, E; Stauffer, EA, 2004) |
| "In a physiological preparation, seizures and failures corresponding to the defective behavior are observed in response to high frequency stimulation." | 5.32 | Treatment with the antiepileptic drugs phenytoin and gabapentin ameliorates seizure and paralysis of Drosophila bang-sensitive mutants. ( Feeney, L; Jacobs, B; McKeever, C; Reynolds, ER; Rojahn, E; Stauffer, EA, 2004) |
| "Spontaneous recurrent seizures were monitored with Racine's seizure severity scale." | 5.32 | Human neural stem cell transplantation reduces spontaneous recurrent seizures following pilocarpine-induced status epilepticus in adult rats. ( Chu, K; Jeon, D; Jeong, SW; Jung, KH; Kim, J; Kim, M; Kim, SU; Lee, SK; Lee, ST; Roh, JK; Shin, HS, 2004) |
| "In the seizure studies, GRP (30-300 ng) increased the latency to tonic seizure, the number of mice convulsing and reduced the incidence of lethality." | 5.31 | Effect of gastrin-releasing peptide on rat hippocampal extracellular GABA levels and seizures in the audiogenic seizure-prone DBA/2 mouse. ( Andrews, N; Davis, B; Gonzalez, MI; McKnight, AT; Oles, R; Singh, L, 2000) |
| "p." | 5.31 | Guanosine and GMP prevent seizures induced by quinolinic acid in mice. ( da Silveira Perla, A; de Faria Maraschin, J; Lara, DR; Onofre Souza, D; Schmidt, AP, 2000) |
| "Bicuculline was used to investigate seizure susceptibility in pre- and peripubertal male and female rats exposed prenatally to morphine." | 5.31 | Prenatal morphine exposure alters susceptibility to bicuculline seizures in a sex- and age-specific manner. ( Schindler, CJ; Slamberová, R; Vathy, I; Velísková, J, 2000) |
| "Seizures were evoked with pilocarpine (400 mg/kg, i." | 5.31 | The effect of CGP-40116 on pilocarpine evoked seizures in mice exposed to transient episode of brain ischemia. ( Czuczwar, SJ; Kleinrok, Z; Rejdak, K; Rejdak, R; Sieklucka-Dziuba, M; Stelmasiak, Z, 2000) |
| "A significant decrease in seizure susceptibility could be observed in BCCA treated mice compared with sham-operated controls." | 5.31 | The influence of MK-801 on bicuculline evoked seizures in adult mice exposed to transient episode of brain ischemia. ( Kleinrok, Z; Rejdak, K; Rejdak, R; Sieklucka-Dziuba, M, 2000) |
| "The purpose of the present investigation was to determine whether the sensitivity to systemic toxic effects of cocaine is altered in genetically epilepsy-prone rats (GEPRs)." | 5.31 | Phenotypic expression of the systemic toxicity of cocaine in genetically epilepsy-prone rats. ( Heavner, JE; Kao, YJ; Kaye, AD; Reigel, CE; Shi, B, 2000) |
| "Moderate seizure (GEPR-3) and severe seizure (GEPR-9) rats, and the control strain, Sprague-Dawley rats, 10 weeks of age, were lightly anesthetized with halothane and nitrous oxide." | 5.31 | Phenotypic expression of the systemic toxicity of cocaine in genetically epilepsy-prone rats. ( Heavner, JE; Kao, YJ; Kaye, AD; Reigel, CE; Shi, B, 2000) |
| "Chronic seizures were induced by amygdalar injection of kainic acid 60 days before death." | 5.31 | Collapse of extracellular glutamate regulation during epileptogenesis: down-regulation and functional failure of glutamate transporter function in rats with chronic seizures induced by kainic acid. ( Doi, T; Kamada, H; Mitsuyama, Y; Nakajima, A; Ohya-Nishiguchi, H; Tokumaru, J; Ueda, Y; Willmore, LJ; Yokoyama, H, 2001) |
| "Limbic seizures were provoked in freely moving rats by intrahippocampal administration of the muscarinic receptor agonist pilocarpine via a microdialysis probe (10 mM for 40 min at 2 microliters/min)." | 5.30 | Hippocampal and cerebellar extracellular amino acids during pilocarpine-induced seizures in freely moving rats. ( Ebinger, G; Michotte, Y; Smolders, I; Van Belle, K, 1997) |
| "Epilepsy is a common condition in people with learning disabilities with many patients continuing to suffer from seizures despite antiepileptic drug (AED) treatment." | 5.30 | A naturalistic study of the use of vigabatrin, lamotrigine and gabapentin in adults with learning disabilities. ( Bhaumik, S; Branford, D; Duggirala, C; Ismail, IA, 1997) |
| "Lamotrigine caused increased seizures in 24% of patients, especially when prescribed at a higher dose." | 5.30 | A naturalistic study of the use of vigabatrin, lamotrigine and gabapentin in adults with learning disabilities. ( Bhaumik, S; Branford, D; Duggirala, C; Ismail, IA, 1997) |
| " In the present study, the effects of maternal cocaine dosage and of cocaine-elicited maternal seizures on the progeny were studied." | 5.30 | Cocaine administration in pregnant rabbits alters cortical structure and function in their progeny in the absence of maternal seizures. ( Fischer, I; Friedman, E; Grayson, D; Jones, L; Levitt, P; Murphy, EH; O'Brien-Jenkins, A; Wang, HY; Wang, XH, 1997) |
| "The incidence of maternal generalized tonic clonic seizures (GTCSs) elicited by cocaine was recorded." | 5.30 | Cocaine administration in pregnant rabbits alters cortical structure and function in their progeny in the absence of maternal seizures. ( Fischer, I; Friedman, E; Grayson, D; Jones, L; Levitt, P; Murphy, EH; O'Brien-Jenkins, A; Wang, HY; Wang, XH, 1997) |
| "Pilocarpine-induced seizures are initiated via muscarinic receptors and further mediated via NMDA receptors." | 5.30 | NMDA receptor-mediated pilocarpine-induced seizures: characterization in freely moving rats by microdialysis. ( Ebinger, G; Khan, GM; Manil, J; Michotte, Y; Smolders, I, 1997) |
| "2." | 5.30 | NMDA receptor-mediated pilocarpine-induced seizures: characterization in freely moving rats by microdialysis. ( Ebinger, G; Khan, GM; Manil, J; Michotte, Y; Smolders, I, 1997) |
| "Theophylline elicited tonic seizures in mice in a dose dependent manner." | 5.30 | Gamma-aminobutyric acid and glutamic acid receptors may mediate theophylline-induced seizures in mice. ( Amabeoku, GJ, 1999) |
| "Behavioral characteristics of seizures have age-dependent features, which suggests that effective treatment of seizures may be age-specific as well." | 5.29 | Age-dependent effects of gamma-aminobutyric acid agents on flurothyl seizures. ( Moshé, SL; Ortíz, J; Ptachewich, Y; Shinnar, S; Velísek, L; Velísková, J, 1995) |
| "tended to decrease seizure intensity and at a dose of 10 mg/kg was ineffective at all." | 5.29 | Further evidence for the interactions between angiotensin II and GABAergic transmission in pentylenetetrazol kindling seizures in mice. ( Georgiev, VP; Kambourova, TS; Lazarova, MB, 1995) |
| "Pyrimethamine dose dependently induced seizures in mice." | 5.29 | GABAergic and dopaminergic systems may be involved in seizures induced by pyrimethamine in mice. ( Amabeoku, G; Chikuni, O, 1994) |
| "Pyridoxine-dependent seizures are a disorder of GABA metabolism probably due to a defective binding of pyridoxal phosphate coenzyme (PALP) with glutamate decarboxylase (GAD), the rate-limiting enzyme in GABA synthesis." | 5.29 | Pyridoxine-dependent seizures associated with white matter abnormalities. ( Giugliani, R; Jardim, LB; Kliemann, FA; Martins, CE; Pires, RF; Vargas, CR; Vizioli, J, 1994) |
| "The seizures were divided into four stages according to their severity." | 5.29 | Altered GABAergic effects on kainic acid-induced seizures in the presence of hippocampal sclerosis in rats. ( Araki, T; Goto, I; Kato, M, 1994) |
| "7 days after the induction of acute seizure, the rats were sacrificed and subjected to histological examinations." | 5.29 | Altered GABAergic effects on kainic acid-induced seizures in the presence of hippocampal sclerosis in rats. ( Araki, T; Goto, I; Kato, M, 1994) |
| "DBA/2 mice were more susceptible to seizures induced by cefazolin than were Swiss mice." | 5.29 | Quinolones potentiate cefazolin-induced seizures in DBA/2 mice. ( Chimirri, A; De Sarro, A; De Sarro, GB; Grasso, S; Zappalá, M, 1993) |
| "The running was followed by seizures and sometimes death." | 5.29 | Inhibition of DFMO-induced audiogenic seizures by chlordiazepoxide. ( Fuller, DJ; Gensler, HL; Gerner, EW; Gerrish, KE, 1993) |
| "Gabapentin (GBP) is a new antiepileptic drug (AED) approved for adjunctive treatment of complex partial seizures with or without seizures secondarily generalization in adults." | 5.29 | Gabapentin associated with aggressive behavior in pediatric patients with seizures. ( Lo, W; Nahata, MC; Tallian, KB; Tsao, CY, 1996) |
| "Seizures associated with intracranial neoplasms are occasionally refractory to conventional anti-epileptic drugs." | 5.29 | Add-on gabapentin for refractory seizures in patients with brain tumours. ( Perry, JR; Sawka, C, 1996) |
| "Complete resolution of seizures occurred in 8/14 patients." | 5.29 | Add-on gabapentin for refractory seizures in patients with brain tumours. ( Perry, JR; Sawka, C, 1996) |
| "To determine whether seizures have age-specific features, we studied the role of gamma-aminobutyric acidB (GABAB) transmission in rats of various ages (9, 15, 30, and 60 postnatal days)." | 5.29 | Age-specific effects of baclofen on pentylenetetrazol-induced seizures in developing rats. ( Moshé, SL; Velísek, L; Velísková, J, 1996) |
| " We conclude that vigabatrin in SSADH deficiency should be administered in a gradually increasing dosage combined with frequent evaluation of the clinical condition and the EEG." | 5.29 | Seizures in a boy with succinic semialdehyde dehydrogenase deficiency treated with vigabatrin (gamma-vinyl-GABA). ( Gibson, KM; Korinthenberg, R; Lehnert, W; Matern, D, 1996) |
| "A stable EEG without the recurrence of seizures as well as renewed improvement of cognitive and behavioural functions was achieved with a reduced vigabatrin dose of 25 mg/kg per day." | 5.29 | Seizures in a boy with succinic semialdehyde dehydrogenase deficiency treated with vigabatrin (gamma-vinyl-GABA). ( Gibson, KM; Korinthenberg, R; Lehnert, W; Matern, D, 1996) |
| "These audiogenic-like seizures were blocked by clobazam microinjection into the substantia nigra (SN) and partially modified by SN vehicle injection." | 5.28 | Neuroethological evaluation of audiogenic seizures and audiogenic-like seizures induced by microinjection of bicuculline into the inferior colliculus. II. Effects of nigral clobazam microinjections. ( Garcia-Cairasco, N; Terra, VC, 1992) |
| "Audiogenic seizures (AS) are a model of generalized tonic-clonic seizures." | 5.28 | Neuroethological evaluation of audiogenic seizures and audiogenic-like seizures induced by microinjection of bicuculline into the inferior colliculus. I. Effects of midcollicular knife cuts. ( Garcia-Cairasco, N; Oliveira, JA; Terra, VC; Tsutsui, J, 1992) |
| "Immature rats are more susceptible to clonic seizures induced by aminooxyacetic acid (AOAA) than mature and senile rats." | 5.28 | Age dependency of the susceptibility of rats to aminooxyacetic acid seizures. ( Cavalheiro, EA; Dziki, M; Kleinrok, Z; Parada, J; Turski, W, 1992) |
| "Bicuculline treatment induced tonic/clonic seizures and status epilepticus in sham operated animals; these effects were drastically diminished at various time points after BCCA." | 5.28 | Transient reduction of cerebral blood flow leads to longlasting increase in GABA content in vulnerable structures and decreased susceptibility to bicuculline induced seizures. ( Block, F; Heim, C; Sieklucka, M; Sontag, KH, 1992) |
| "In other groups of rats seizures were elicited by i." | 5.28 | Transient reduction of cerebral blood flow leads to longlasting increase in GABA content in vulnerable structures and decreased susceptibility to bicuculline induced seizures. ( Block, F; Heim, C; Sieklucka, M; Sontag, KH, 1992) |
| "2." | 5.28 | Involvement of GABAergic mechanisms in chloroquine-induced seizures in mice. ( Amabeoku, G, 1992) |
| "In a previous work, we have shown that seizures lead to an age-dependent upregulation of central benzodiazepine binding sites measured in isolated rat cerebral membranes." | 5.28 | Autoradiographic changes in central benzodiazepine binding sites and their coupling to gamma-aminobutyric acid receptors after seizures in the developing rat. ( Daval, JL; Werck, MC, 1991) |
| "The incidences of both seizure and death for strychnine and death for picrotoxin were enhanced by treatment with GES, whereas the latency of pentetrazole-induced tonic extensor was prolonged." | 5.28 | [Drug-induced seizures in taurine-deficient mice]. ( Araki, H; Sano, M; Shimada, C; Tanaka, S, 1991) |
| "At the onset of convulsions we found a 40-45% decrease in the K(+)-stimulated release of GABA." | 5.28 | Transmitter release in hippocampal slices from rats with limbic seizures produced by systemic administration of kainic acid. ( Arias, C; Montiel, T; Tapia, R, 1990) |
| "Glycine content was reduced preictally only in the substantia nigra; after seizure onset its concentration rose in all brain areas." | 5.27 | Alterations in the content of amino acid neurotransmitters before the onset and during the course of methoxypyridoxine-induced seizures in individual rabbit brain regions. ( Haug, P; Nitsch, C; Schmude, B, 1983) |
| "In rabbits, generalized seizures were induced by methoxypyridoxine, and changes in amino acid concentrations of 15 brain regions were investigated before seizure onset and during the course of sustained epileptiform activity." | 5.27 | Alterations in the content of amino acid neurotransmitters before the onset and during the course of methoxypyridoxine-induced seizures in individual rabbit brain regions. ( Haug, P; Nitsch, C; Schmude, B, 1983) |
| "L-Allylglycine seizures are associated with generalized decreases in GABA concentrations (-32 to -54%), increases in glutamine concentrations (+10 to +53%), and a decrease in cortical aspartate concentration (-14%)." | 5.27 | Changes in regional neurotransmitter amino acid levels in rat brain during seizures induced by L-allylglycine, bicuculline, and kainic acid. ( Chapman, AG; Meldrum, BS; Premachandra, M; Westerberg, E, 1984) |
| "Repeated kindled seizures result in increased numbers of benzodiazepine receptors in fascia dentata membranes." | 5.27 | Kindled seizures result in decreased responsiveness of benzodiazepine receptors to gamma-aminobutyric acid (GABA). ( Fanelli, RJ; McNamara, JO, 1983) |
| "Pyridoxine-dependent seizures occur as a result of an increased requirement of the vitamin within the central nervous system." | 5.27 | Pyridoxine-dependent seizures. ( Crowell, GF; Roach, ES, 1983) |
| "During 1 h of bicuculline-induced seizures (1." | 5.27 | Cortical GABA turnover during bicuculline seizures in rats. ( Chapman, AG; Evans, MC, 1983) |
| "It also prevented pentylenetetrazol seizures in rats in a four times lower dose." | 5.27 | Antagonism of seizures induced by the administration of the endogenous convulsant quinolinic acid into rat brain ventricles. ( Kiseleva, IP; Lapin, IP; Prakhie, IB, 1986) |
| "significantly increased seizure protection and seizure latency (the time required to develop seizures after PTZ injection) with a peak effect dose at 10 mmol/kg." | 5.27 | Effects of L-lysine and its metabolites on pentylenetetrazol-induced seizures. ( Chang, YF; Myslinski, NR, 1985) |
| "The latency to clonic convulsion was dramatically affected by prior shock treatment, and the direction of this change depended upon the escapability/inescapability of the shock." | 5.27 | Coping and seizure susceptibility: control over shock protects against bicuculline-induced seizures. ( Alpern, HP; Drugan, RC; Maier, SF; McIntyre, TD, 1985) |
| "In mice, running, clonic and tonic convulsions and lethality were assessed following transcorneal (electroshock) current or convulsant drugs, each administered alone and after cannabidiol (CBD) pretreatment." | 5.26 | Effects of cannabidiol on behavioral seizures caused by convulsant drugs or current in mice. ( Benedito, MA; Carlini, EA; Consroe, P; Leite, JR; Mechoulam, R, 1982) |
| "Myoclonic seizures of the hindlegs are induced in mice by l- and d,l-kynurenine." | 5.26 | Kynurenines and seizures. ( Lapin, IP, 1981) |
| "Electroconvulsive seizures administered during the period of fetal benzodiazepine (BZ) binding site proliferation (days 16, 18 and 20 in gestation) significantly decreased the density of cerebral cortical benzodiazepine binding sites in exposed pups up to 21 days postnatal age." | 5.26 | Prenatal exposure to electroconvulsive seizures and phenytoin: development of benzodiazepine binding sites, reflex behaviors and seizure thresholds in exposed offspring. ( Gallager, DW; Wakeman, EA, 1982) |
| "The onset of clonic seizures induced by 3-mercaptopropionic acid (MP) was associated with an approximately 200% increase of cAMP and a 70% elevation of cGMP in the mouse cerebral cortex." | 5.26 | Cyclic GMP and cyclic AMP in the cerebral cortex of mice during seizures induced by 3-mercaptopropionic acid: effects of anticonvulsant agents. ( Folbergrová, J, 1980) |
| "When MP convulsions were prevented by Na-phenobarbital, the levels of both nucleotides were not different from control concentrations." | 5.26 | Cyclic GMP and cyclic AMP in the cerebral cortex of mice during seizures induced by 3-mercaptopropionic acid: effects of anticonvulsant agents. ( Folbergrová, J, 1980) |
| "Afterdischarge duration, motor seizure latency, motor seizure duration and motor seizure stage were scored." | 5.26 | Pharmacological investigation of gamma-aminobutyric acid (GABA) and fully-developed generalized seizures in the amygdala-kindled rat. ( Burnham, WM; Kalichman, MW; Livingston, KE, 1982) |
| "Penicillin seizures do not cause a change in levels of GABA, but result in a decrease in glutamate within the focus." | 5.26 | Effect of amino-oxyacetic acid (AOAA) on focal penicillin seizures. ( Collins, RC; Mehta, S, 1978) |
| "beta-Alanine is a central-nervous-system depressant." | 5.24 | Hyper-beta-alaninemia associated with beta-aminoaciduria and gamma-aminobutyricaciduria, somnolence and seizures. ( Davies, E; Pueschel, S; Scriver, CR, 1966) |
| "To evaluate the comparative safety and adjunctive efficacy of pregabalin and gabapentin in reducing seizure frequency in patients with partial-onset seizures based on prestudy modeling showing superior efficacy for pregabalin." | 5.22 | Adjunctive pregabalin vs gabapentin for focal seizures: Interpretation of comparative outcomes. ( Almas, M; French, J; Friedman, D; Glue, P; Knapp, L; Pitman, V; Posner, HB; Yardi, N, 2016) |
| "The design of this comparative efficacy and safety study of pregabalin and gabapentin as adjunctive treatment in adults with refractory partial-onset seizures was randomized, flexible dose, double blind, and parallel group." | 5.22 | Adjunctive pregabalin vs gabapentin for focal seizures: Interpretation of comparative outcomes. ( Almas, M; French, J; Friedman, D; Glue, P; Knapp, L; Pitman, V; Posner, HB; Yardi, N, 2016) |
| "This study provides Class II evidence that for patients with partial seizures enrolled in this study, pregabalin is not superior to gabapentin in reducing seizure frequency." | 5.22 | Adjunctive pregabalin vs gabapentin for focal seizures: Interpretation of comparative outcomes. ( Almas, M; French, J; Friedman, D; Glue, P; Knapp, L; Pitman, V; Posner, HB; Yardi, N, 2016) |
| "To evaluate the long-term efficacy of gabapentin (GBP) and usefulness of measurement of the blood level for the observation of patients that have partial seizures." | 5.19 | The efficacy of gabapentin in children of partial seizures and the blood levels. ( Ishii, M; Iwasaki, T; Nonoda, Y, 2014) |
| " Data from a large database (Pfizer Inc) which studied add-on pregabalin for the treatment of partial seizures was used to model how duration of baseline, post-randomization treatment period, and number of subjects impact the likelihood of an interpretable efficacy signal." | 5.17 | Designing a new proof-of-principle trial for treatment of partial seizures to demonstrate efficacy with minimal sample size and duration-a case study. ( Cabrera, J; Emir, B; French, JA; Lu, F; Whalen, E, 2013) |
| "Four-hundred and thirty-four patients with partial seizures were randomized to pregabalin, lamotrigine, or placebo as adjunctive therapy for 17 weeks of double-blind treatment." | 5.14 | A comparison of pregabalin, lamotrigine, and placebo as adjunctive therapy in patients with refractory partial-onset seizures. ( Barrett, J; Baulac, M; Leon, T; O'Brien, TJ; Whalen, E, 2010) |
| "During phase I, there was a nonsignificant trend toward a greater reduction in seizures with pregabalin versus placebo and lamotrigine." | 5.14 | A comparison of pregabalin, lamotrigine, and placebo as adjunctive therapy in patients with refractory partial-onset seizures. ( Barrett, J; Baulac, M; Leon, T; O'Brien, TJ; Whalen, E, 2010) |
| "Pregabalin was demonstrated to be noninferior to lamotrigine in the treatment of refractory partial seizures." | 5.14 | A comparison of pregabalin, lamotrigine, and placebo as adjunctive therapy in patients with refractory partial-onset seizures. ( Barrett, J; Baulac, M; Leon, T; O'Brien, TJ; Whalen, E, 2010) |
| "This study assessed the comparative efficacy of pregabalin for refractory partial seizures." | 5.14 | A comparison of pregabalin, lamotrigine, and placebo as adjunctive therapy in patients with refractory partial-onset seizures. ( Barrett, J; Baulac, M; Leon, T; O'Brien, TJ; Whalen, E, 2010) |
| "To evaluate bodyweight gain during pregabalin therapy for epilepsy and the utility of a short counseling program to prevent this side effect." | 5.13 | Bodyweight gain under pregabalin therapy in epilepsy: mitigation by counseling patients? ( Elger, CE; Hoffmann, JM; Hoppe, C; Rademacher, M; Schmidt, D, 2008) |
| "Randomized controlled trial on the effects of extended versus standard patient counseling on the risk of bodyweight gain with 3- and 6-month follow-up including a consecutive sample of adult outpatients with epilepsy eligible for pregabalin add-on treatment (N=98)." | 5.13 | Bodyweight gain under pregabalin therapy in epilepsy: mitigation by counseling patients? ( Elger, CE; Hoffmann, JM; Hoppe, C; Rademacher, M; Schmidt, D, 2008) |
| "Pregabalin treatment is associated with a high risk for bodyweight gain which in part depends on total anticonvulsant drug load." | 5.13 | Bodyweight gain under pregabalin therapy in epilepsy: mitigation by counseling patients? ( Elger, CE; Hoffmann, JM; Hoppe, C; Rademacher, M; Schmidt, D, 2008) |
| " At our institution, new-onset seizures in children on chemotherapy are treated with gabapentin, a nonhepatic enzyme inducer." | 5.11 | Gabapentin to control seizures in children undergoing cancer treatment. ( Hunt, DL; Khan, RB; Thompson, SJ, 2004) |
| "The aim of the study was to find out the percentage of patients with localization-related epilepsy achieving complete seizure control with gabapentin (GBP) add-on therapy." | 5.09 | Gabapentin add-on treatment: how many patients become seizure-free? An open-label multicenter study. ( Elger, CE; Mayer, T; Schütte, W; Wolf, P, 1999) |
| "Studies in patients with epilepsy undergoing telemetry evaluation for surgery have suggested that discontinuation of carbamazepine (CBZ) is associated with increased seizures." | 5.09 | Increased seizures after discontinuing carbamazepine: results from the gabapentin monotherapy trial. ( DeToledo, JC; Garofalo, EA; Greiner, M; Lowe, MR; Ramsay, RE, 2000) |
| "Vigabatrin is a novel antiepileptic drug designed to control seizures by raising brain gamma-aminobutyric acid (GABA) concentrations." | 5.08 | Human brain gamma-aminobutyric acid levels and seizure control following initiation of vigabatrin therapy. ( Behar, KL; Mattson, RH; Petroff, OA; Rothman, DL, 1996) |
| "Vigabatrin (VGB) has been shown through several studies to be safe and effective as add-on therapy, particularly for the treatment of partial seizures in patients with severe epilepsies followed for years in hospital-based clinics." | 5.08 | Multicentre clinical evaluation of vigabatrin (Sabril) in mild to moderate partial epilepsies. French Neurologists Sabril Study Group. ( Arzimanoglou, AA; Dumas, C; Ghirardi, L, 1997) |
| "Fifty patients with refractory partial seizures took part in a prospective, observational study of adjuvant gabapentin (GBP) in increasing doses." | 5.08 | High dose gabapentin in refractory partial epilepsy: clinical observations in 50 patients. ( Brodie, MJ; Forrest, G; Sills, GJ; Wilson, EA, 1998) |
| "The effect of gabapentin on cognition and quality of life (QoL) in patients with epilepsy was investigated using a controlled pre- and post-treatment design." | 5.08 | Effects of gabapentin on cognition and quality of life in patients with epilepsy. ( Emmers, E; Mortimore, C; Trimble, M, 1998) |
| "Gabapentin is widely approved as add-on therapy for epilepsy treatment for partial seizures with and without secondary generalization." | 5.08 | A double-blind trial of gabapentin monotherapy for newly diagnosed partial seizures. International Gabapentin Monotherapy Study Group 945-77. ( Alexander, J; Anhut, H; Chadwick, DW; Garofalo, EA; Greiner, MJ; Murray, GH; Pierce, MW, 1998) |
| "The results of a multicenter, double-blind, placebo-controlled clinical trial of the efficacy and safety of progabide (PGB) in the treatment of partial seizures are presented." | 5.06 | A controlled study of progabide in partial seizures: methodology and results. ( Bowman, T; Cloyd, J; Crosby, C; Dreifuss, FE; Graves, N; Jacobs, M; Leppik, IE; Porter, R; Santilli, N; Stackman, J, 1987) |
| " Drug interactions were studied during a randomized, double-blind, crossover trial of the efficacy and toxicity of PGB in patients with partial seizures taking phenytoin (PHT) and carbamazepine (CBZ)." | 5.06 | Effect of progabide on serum phenytoin and carbamazepine concentrations. ( Brundage, RC; Cloyd, JC; Graves, NM; Leppik, IE; Welty, TE, 1987) |
| "Clinically significant side effects of the new anticonvulsants, such as metabolic acidosis from topiramate, autoimmune reactions from lamotrigine, hyponatremia from oxcarbazepine, or psychosis from levitiracetam can cause serious morbidity and mortality if unrecognized." | 4.86 | Emergent complications of the newer anticonvulsants. ( Dang, CV; Nelson, L; Wade, JF; Wasserberger, J, 2010) |
| "To determine whether pregabalin reduces SGTC seizures in clinically refractory epilepsy." | 4.84 | Reduction of secondarily generalized tonic-clonic (SGTC) seizures with pregabalin. ( Briggs, DE; French, JA; Lee, CM; Spiegel, K, 2008) |
| " A significant reduction in absolute SGTC seizures from baseline was observed in patients receiving pregabalin 600 mg/day (treatment RRatio, -33 versus placebo, -3." | 4.84 | Reduction of secondarily generalized tonic-clonic (SGTC) seizures with pregabalin. ( Briggs, DE; French, JA; Lee, CM; Spiegel, K, 2008) |
| "As adjunctive therapy, pregabalin 600 mg/day is effective in reducing the absolute frequency of SGTC seizures in patients with refractory partial epilepsy, but not secondary generalization." | 4.84 | Reduction of secondarily generalized tonic-clonic (SGTC) seizures with pregabalin. ( Briggs, DE; French, JA; Lee, CM; Spiegel, K, 2008) |
| "Pyridoxine-dependent seizures have been recognised for 40 years, but the clinical and biochemical features are still not understood." | 4.82 | Pyridoxine-dependent seizures: a clinical and biochemical conundrum. ( Baxter, P, 2003) |
| "Pregabalin is a gamma-aminobutyric acid analog that is under development by Pfizer for the potential treatment of central nervous system disorders, including epilepsy, neuropathic pain, fibromyalgia and generalized anxiety disorder." | 4.82 | Pregabalin (Pfizer). ( Huckle, R, 2004) |
| "To review pregabalin's pharmacology, pharmacokinetics, efficacy, and adverse effects in the treatment of neuropathic pain, epilepsy, and anxiety." | 4.82 | Pregabalin: a new neuromodulator with broad therapeutic indications. ( McAuley, JW; Shneker, BF, 2005) |
| " Key terms were anxiety, diabetic neuropathy, epilepsy, neuropathic pain, postherpetic neuralgia, pregabalin, and seizures." | 4.82 | Pregabalin: a new neuromodulator with broad therapeutic indications. ( McAuley, JW; Shneker, BF, 2005) |
| "Three new antiepileptic drugs--vigabatrin, gabapentin, and lamotrigine--provide alternatives in the management of older patients with refractory partial seizures." | 4.79 | Seizure control: how to use the new antiepileptic drugs in older patients. ( Haider, A; Haider, S; Tuchek, JM, 1996) |
| "Since 1994, three new antiepileptic drugs, felbamate, lamotrigene, and gabapentin, have been released for the treatment of epilepsy." | 4.79 | A review of the newer antiepileptic drugs and the ketogenic diet. ( Barron, TF; Hunt, SL, 1997) |
| " Both zinc and pyridoxal phosphate (PLP) deficiency and excess have been reported to produce epileptiform seizures, which are blocked by gamma-aminobutyric acid (GABA)." | 4.78 | Hippocampal zinc thionein and pyridoxal phosphate modulate synaptic functions. ( Ebadi, M; Murrin, LC; Pfeiffer, RF, 1990) |
| "The substantia nigra has been identified as a critical site at which gamma-aminobutyric acid (GABA) agonist drugs act to reduce susceptibility to a number of types of experimentally induced generalized seizures." | 4.77 | Mechanisms of seizure control mediated by gamma-aminobutyric acid: role of the substantia nigra. ( Gale, K, 1985) |
| "Relative to wild-type (WT) mice, the tremor mice presented: increased tremors and bradykinesia associated with postural instability, decreased range of motion, and difficulty in initiating voluntary movements directly proportional to age; reduced step length for right and left hindlimbs; reduced cortical GABA, glutamate and, aspartate levels, the DOPAC/DA and ratio and increased the NOR levels; in the striatum, the levels of glycine and aspartate were reduced while the HVA levels, the HVA/DA and 5HIAA/5-HT ratios increased; in the cerebellum the glycine, NOR and 5-HIAA levels increased." | 4.31 | Progressive tremor and motor impairment in seizure-prone mutant tremor mice are associated with neurotransmitter dysfunction. ( Alexandre-Ribeiro, SR; Bernardi, MM; Bondan, EF; Coque, AC; Flório, JC; Garcia-Gomes, MSA; Gonçalves, FB; Kirsten, TB; Lebrun, I; Massironi, SMG; Mori, CMC; Sandini, TM; Silva-Sampaio, AC, 2023) |
| " Hence, the methanol extract was further explored for its anticonvulsant potential in pentylenetetrazole (PTZ) induced acute seizures in mice." | 4.31 | Anticonvulsant potential of Grewia tiliaefolia in pentylenetetrazole induced epilepsy: insights from in vivo and in silico studies. ( Arora, S; Kaur, S; Kumar, N; Rajput, A; Sharma, P; Singh Bedi, PM; Singh, B; Singh, H; Singh, S; Singh, T, 2023) |
| "Rats with hHCy developed more severe stages of behavioral patterns during flurothyl-induced epilepsy with shorter latency." | 4.31 | Maternal hyperhomocysteinemia increases seizures susceptibility of neonatal rats. ( Gataulina, E; Gerasimova, E; Khalilov, I; Kurmashova, E; Sitdikova, GF; Yakovlev, AV, 2023) |
| " The compound had a pronounced anticonvulsant effect, significantly reducing the mortality of mice in models of seizures induced by pentylenetetrazole, picrotoxin, strychnine, and caffeine." | 4.12 | Promising anticonvulsant N-[(2,4-dichlorophenyl) methyl]-2-(2,4-dioxo-1H-quinazolin-3-yl) acetamide: dose-dependent study and evaluation of anticonvulsant action spectrum in vivo and in silico. ( Georgiyants, V; Kayal, WE; Mishchenko, M; Severina, H; Shtrygol, D; Shtrygol, S; Zalevskyi, S, 2022) |
| " OV329, a novel drug candidate for the treatment of epilepsy and addiction, has been shown in vitro to be substantially more potent as a GABA-AT inactivator than vigabatrin, an antiseizure drug approved as an add-on therapy for adult patients with refractory complex partial seizures and monotherapy for pediatric patients with infantile spasms." | 4.02 | OV329, a novel highly potent γ-aminobutyric acid aminotransferase inactivator, induces pronounced anticonvulsant effects in the pentylenetetrazole seizure threshold test and in amygdala-kindled rats. ( Deking, LS; During, MJ; Feja, M; Gernert, M; Kaczmarek, E; Meller, S; Silverman, RB, 2021) |
| "These results reveal an anticonvulsant profile of OV329 that appears to be superior in both potency and efficacy to vigabatrin and highlight OV329 as a highly promising candidate for the treatment of seizures and pharmacoresistant epilepsies." | 4.02 | OV329, a novel highly potent γ-aminobutyric acid aminotransferase inactivator, induces pronounced anticonvulsant effects in the pentylenetetrazole seizure threshold test and in amygdala-kindled rats. ( Deking, LS; During, MJ; Feja, M; Gernert, M; Kaczmarek, E; Meller, S; Silverman, RB, 2021) |
| "We therefore examined the effects of OV329 (5, 20, and 40 mg/kg ip) on the seizure threshold of female Wistar Unilever rats, using the timed intravenous pentylenetetrazole (ivPTZ) seizure threshold model as a seizure test particularly sensitive to GABA-potentiating manipulations, and amygdala-kindled rats as a model of difficult-to-treat temporal lobe epilepsy." | 4.02 | OV329, a novel highly potent γ-aminobutyric acid aminotransferase inactivator, induces pronounced anticonvulsant effects in the pentylenetetrazole seizure threshold test and in amygdala-kindled rats. ( Deking, LS; During, MJ; Feja, M; Gernert, M; Kaczmarek, E; Meller, S; Silverman, RB, 2021) |
| " We generated GABAergic interneuron precursors from human embryonic stem cells (hESCs) and grafted them in the hippocampi of rats developing chronic SRSs after kainic acid-induced status epilepticus." | 4.02 | Human Stem Cell-Derived GABAergic Interneurons Establish Efferent Synapses onto Host Neurons in Rat Epileptic Hippocampus and Inhibit Spontaneous Recurrent Seizures. ( Andersson, M; Gonzalez-Ramos, A; Kokaia, M; Kudláček, J; Ledri, M; Mikroulis, A; Waloschková, E, 2021) |
| "The goal of our study was to examine the long-term effect of vigabatrin (VGB), a γ-aminobutyric acid aminotransferase (GABA-AT) inhibitor on clonazepam (CLO), ethosuximide (ETX) and valproate (VPA) anticonvulsive activity against pentylenetetrazole (PTZ)-induced seizures in mice." | 3.96 | Long-term vigabatrin treatment modifies pentylenetetrazole-induced seizures in mice: focused on GABA brain concentration. ( Czuczwar, SJ; Krzyżanowski, M; Świąder, K; Świąder, MJ; Wróbel, A; Zakrocka, I; Łuszczki, JJ, 2020) |
| "Recurrent seizures (RS) were induced by flurothyl inhalation in immature rats." | 3.96 | Recurrent seizures cause immature brain injury and changes in GABA a receptor α1 and γ2 subunits. ( Feng, J; Hu, XY; Shi, XY; Tang, JH; Wan, Y; Xi, XJ; Zhang, BB; Zhou, C, 2020) |
| " Eighty-four male Balb/C mice were divided into 7 groups: control-naïve, pentylenetetrazole (PTZ)-induced seizures, PTZ-calcitonin, PTZ-valproic acid, PTZ-pregabalin, PTZ-calcitonin-valproic acid (PCV) combination, and PTZ-calcitonin-pregabalin (PCP) combination." | 3.88 | Calcitonin potentiates the anticonvulsant and antinociceptive effects of valproic acid and pregabalin in pentylenetetrazole-kindled mice. ( Ashour, RH; El-Beltagi, HM; Hamada, NM; Shalaby, AA, 2018) |
| "Absence seizures (ASs) are associated with abnormalities in gamma-aminobutyric acid (GABA) neurotransmission in the thalamus and the cortex." | 3.88 | Developmental changes of GABA immunoreactivity in cortico-thalamic networks of an absence seizure model. ( Bombardi, C; Crunelli, V; Di Giovanni, G; Venzi, M, 2018) |
| " Here we report that dipropofol exerted anticonvulsant activity in a mouse model of kainic acid-induced seizures." | 3.88 | Anticonvulsant effect of dipropofol by enhancing native GABA currents in cortical neurons in mice. ( An, L; Chen, X; Huang, Z; Kårbø, M; Wang, K; Wang, R; Zhang, J; Zhao, Y, 2018) |
| "In a large cohort of older patients with a seizure disorder, pregabalin was not associated with an increased risk of heart failure relative to gabapentin." | 3.85 | Pregabalin and heart failure: A population-based study. ( Antoniou, T; Gomes, T; Ho, JM; Juurlink, DN; Luo, J; Macdonald, EM; Mamdani, MM, 2017) |
| "The anticonvulsant pregabalin is increasingly prescribed for pain, seizures, and psychiatric disorders." | 3.85 | Pregabalin and heart failure: A population-based study. ( Antoniou, T; Gomes, T; Ho, JM; Juurlink, DN; Luo, J; Macdonald, EM; Mamdani, MM, 2017) |
| " All the synthesized title derivatives were assessed for in vivo anticonvulsant screening by the two most employed standard animal seizure models, maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole (scPTZ)-induced seizures, along with minimal motor impairment screening by rotarod test." | 3.83 | Design, Synthesis, and Biological Evaluation of 6-(2-Amino-substituted phenyl)-4-(substituted phenyl)-1,2,4-triazine-3,5(2H,4H)-dione Derivatives as Anticonvulsant Agents. ( Akhtar, MJ; Ali, Z; Khan, AA; Siddiqui, N; Yar, MS, 2016) |
| " Additionally, noneffective doses of either KATP channel opener (cromakalim) or nonselective μ-opioid receptor agonist (morphine) in combination with a noneffective dose of zolpidem exerted a significant anticonvulsive effect on PTZ-induced seizures in mice." | 3.83 | Involvement of ATP-sensitive potassium channels and the opioid system in the anticonvulsive effect of zolpidem in mice. ( Amiri, S; Dehdashtian, A; Dehpour, AR; Ghasemi, M; Ostadhadi, S; Sheikhi, M; Shirzadian, A, 2016) |
| " The maximal electroshock test (MES) and pentylenetertrazole (PTZ)-induced seizures in male mice were used to evaluate anticonvulsant activities of eudesmin, and sedative effects of eudesmin were evaluated by pentobarbital sodium-induced sleeping time (PST) and locomotor activity in mice." | 3.81 | Anticonvulsant and Sedative Effects of Eudesmin isolated from Acorus tatarinowii on mice and rats. ( He, J; Lei, JP; Liao, DG; Liu, F; Liu, H; Luo, K; Song, Z; Yang, L; Zhang, TY; Zhuang, K, 2015) |
| "An 8-year-old girl treated at our facility for superrefractory status epilepticus was found to have a low pyridoxine level at 5 μg/L." | 3.81 | Pyridoxine deficiency in adult patients with status epilepticus. ( Dave, HN; Eugene Ramsay, R; Irland, M; Khan, F; Sabharwal, V, 2015) |
| " We report that, among a spectrum of in vivo activities, both 15b and 15c displayed significant activity against pentylenetetrazole (PTZ)-induced seizures." | 3.80 | Synthesis, biological evaluation and structure-activity relationship of new GABA uptake inhibitors, derivatives of 4-aminobutanamides. ( Filipek, B; Höfner, GC; Kowalczyk, P; Kulig, K; Mucha, M; Podkowa, A; Rapacz, A; Sałat, K; Wanner, KT, 2014) |
| "These data indicate that MSCs were superior to gabapentin in ameliorating PTZ-induced epileptogenesis and verified the potential use of MSCs in seizure control, motor and cognitive impairments, oxidative stress, and the impairing GABA level in experimentally induced epilepsy." | 3.80 | Effects of intravenous human umbilical cord blood mesenchymal stem cell therapy versus gabapentin in pentylenetetrazole-induced chronic epilepsy in rats. ( Essawy, SS; Ewais, MM; Mohammed, AS; Tawfik, MK, 2014) |
| " To analyse early processes in epileptogenesis we used the juvenile pilocarpine model to study status epilepticus (SE)-induced changes in expression of key components in the glutamate-glutamine cycle, known to be affected in MTS patients." | 3.80 | Persistent reduction of hippocampal glutamine synthetase expression after status epilepticus in immature rats. ( Bos, IW; de Graan, PN; Hessel, EV; Mulder, SD; van der Hel, WS; van Eijsden, P; Verlinde, SA, 2014) |
| "Latrunculin A microperfusion of the hippocampus induces acute epileptic seizures and long-term biochemical changes leading to spontaneous seizures." | 3.80 | Effects of eslicarbazepine acetate on acute and chronic latrunculin A-induced seizures and extracellular amino acid levels in the mouse hippocampus. ( Loureiro, AI; Sierra-Marcuño, G; Sierra-Paredes, G; Soares-da-Silva, P; Wright, LC, 2014) |
| "Oral administration of ESL (100 mg/kg), previous to latrunculin A microperfusion, completely prevented acute latrunculin A-induced seizures as well as chronic seizures and all EEG chronic signs of paroxysmal activity." | 3.80 | Effects of eslicarbazepine acetate on acute and chronic latrunculin A-induced seizures and extracellular amino acid levels in the mouse hippocampus. ( Loureiro, AI; Sierra-Marcuño, G; Sierra-Paredes, G; Soares-da-Silva, P; Wright, LC, 2014) |
| "ESL treatment prevented acute latrunculin A-induced seizures as well as chronic seizures and all EEG chronic signs of paroxysmal activity, supporting a possible anti-epileptogenic effect of ESL in mice." | 3.80 | Effects of eslicarbazepine acetate on acute and chronic latrunculin A-induced seizures and extracellular amino acid levels in the mouse hippocampus. ( Loureiro, AI; Sierra-Marcuño, G; Sierra-Paredes, G; Soares-da-Silva, P; Wright, LC, 2014) |
| " While seizures are usually intractable to medication in tuberous sclerosis complex (TSC), a common genetic cause of epilepsy, vigabatrin appears to have unique efficacy for epilepsy in TSC." | 3.79 | Vigabatrin inhibits seizures and mTOR pathway activation in a mouse model of tuberous sclerosis complex. ( McDaniel, SS; Rensing, NR; Wong, M; Zhang, B, 2013) |
| "Rats were given unilateral kainate injection into hippocampal CA3 region, and the effect of chronic electrographic seizures on extracellular glutamine (GLNECF) was examined in those with low and steady levels of extracellular glutamate (GLUECF)." | 3.79 | Electrographic seizures are significantly reduced by in vivo inhibition of neuronal uptake of extracellular glutamine in rat hippocampus. ( Kanamori, K; Ross, BD, 2013) |
| "The lithium-pilocarpine model of epilepsy reproduces in rodents several features of human temporal lobe epilepsy, by inducing an acute status epilepticus (SE) followed by a latency period." | 3.79 | Gabapentin administration reduces reactive gliosis and neurodegeneration after pilocarpine-induced status epilepticus. ( Angelo, MF; Lukin, J; Ramos, AJ; Rossi, AR; Villarreal, A, 2013) |
| "To determine the efficacy of pregabalin (PGB) in treatment of frequent nonconvulsive seizures (NCS) and nonconvulsive status epilepticus (NCSE) in critically ill patients." | 3.79 | Use of pregabalin for nonconvulsive seizures and nonconvulsive status epilepticus. ( Doreswamy, M; Husain, AM; Swisher, CB, 2013) |
| "Pregabalin may be safe option for add-on treatment for nonconvulsive seizures in critically ill patients when conventional therapy fails." | 3.79 | Use of pregabalin for nonconvulsive seizures and nonconvulsive status epilepticus. ( Doreswamy, M; Husain, AM; Swisher, CB, 2013) |
| " Our data have demonstrated that pentylenetetrazole (PTZ)-induced seizures did not alter ATP, ADP, and AMP hydrolysis in brain membrane fractions." | 3.79 | Antiepileptic drugs prevent changes in adenosine deamination during acute seizure episodes in adult zebrafish. ( Bogo, MR; Bonan, CD; Nery, LR; Piato, AL; Schaefer, IC; Siebel, AM, 2013) |
| " We here investigated for the first time the effect of L-theanine intake on seizure susceptibility using acute pilocarpine and pentylenetetrazol (PTZ) mouse models for studying, respectively, limbic seizures or primarily generalized seizures." | 3.79 | L-Theanine intake increases threshold for limbic seizures but decreases threshold for generalized seizures. ( Loyens, E; Massie, A; Michotte, Y; Schallier, A; Smolders, I; Van Liefferinge, J; Vermoesen, K, 2013) |
| "To investigate the anticonvulsant activity of the lobeline isolated from the Lobelia nicotianaefolia in chemoconvulsant-induced seizures and its biochemical mechanism by investigating relationship between seizure activities and altered gamma amino butyric acid (GABA) in brain of mice in Pentylenetetrazol (PTZ) seizure models." | 3.78 | Antiepileptic activity of lobeline isolated from the leaf of Lobelia nicotianaefolia and its effect on brain GABA level in mice. ( Bodhankar, SL; Ghosh, P; Rub, RA; Tamboli, AM, 2012) |
| "In our findings, isolated lobeline (20mg/kg) exhibited potent anticonvulsant activity against PTZ induced seizures." | 3.78 | Antiepileptic activity of lobeline isolated from the leaf of Lobelia nicotianaefolia and its effect on brain GABA level in mice. ( Bodhankar, SL; Ghosh, P; Rub, RA; Tamboli, AM, 2012) |
| "In this study, we investigated the role of GABAergic and glutamatergic systems in the anticonvulsant action of 3-alkynyl selenophene (3-ASP) in a pilocarpine (PC) model of seizures." | 3.78 | Involvement of GABAergic and glutamatergic systems in the anticonvulsant activity of 3-alkynyl selenophene in 21 day-old rats. ( Bortolatto, CF; Gai, BM; Nogueira, CW; Roehrs, JA; Souza, AC; Wilhelm, EA, 2012) |
| "Glutaric acidemia type I (GA-I) is an inherited metabolic disease characterized by accumulation of glutaric acid (GA) and seizures." | 3.78 | m-Trifluoromethyl diphenyl diselenide attenuates glutaric acid-induced seizures and oxidative stress in rat pups: involvement of the γ-aminobutyric acidergic system. ( Brüning, CA; Fighera, MR; Gai, BM; Magni, DV; Nogueira, CW; Quines, CB; Rosa, SG, 2012) |
| "This study was aimed at investigating the anticonvulsant activity of lipoic acid (LA) against pilocarpine-induced seizures as well as the effects of this metabolic antioxidant on the hippocampal extracellular concentrations of amino acid neurotransmitters glutamate, aspartate, glycine and glutamate and γ-aminobutyric acid (GABA)." | 3.77 | Lipoic acid alters amino acid neurotransmitters content in rat hippocampus after pilocarpine-induced seizures. ( de Freitas, RM; de Oliveira Silva, F; Jordán, J; Saldanha, GB, 2011) |
| " Therefore, we tested whether LY293558 is effective against soman-induced seizures and neuropathology, when administered 1 h after soman exposure, in rats." | 3.77 | The GluK1 (GluR5) Kainate/{alpha}-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist LY293558 reduces soman-induced seizures and neuropathology. ( Apland, JP; Aroniadou-Anderjaska, V; Braga, MF; Figueiredo, TH; Qashu, F; Souza, AP, 2011) |
| "Pregabalin (PGB) was licensed in Europe as an add-on antiepileptic drug (AED) for the treatment of partial-onset seizures in 2004." | 3.77 | Adjunctive pregabalin for uncontrolled partial-onset seizures: findings from a prospective audit. ( Brodie, MJ; Kelly, K; Leach, V; Parker, P; Stephen, LJ; Wilson, EA, 2011) |
| "The present study was focused to characterize the effects of intrahippocampal application of R-verapamil, a P-glycoprotein blocker, and High Frequency Electrical Stimulation (HFS) at 130 Hz, on seizure susceptibility and extracellular concentrations of glutamate and γ-aminobutyric acid (GABA) in hippocampus of kindled rats with drug-resistant seizures." | 3.77 | Effects of high frequency electrical stimulation and R-verapamil on seizure susceptibility and glutamate and GABA release in a model of phenytoin-resistant seizures. ( Luna-Munguia, H; Orozco-Suarez, S; Rocha, L, 2011) |
| "Gabapentin is an antiepileptic drug used as adjunct therapy in the treatment of seizures." | 3.77 | Performance characteristics of the ARK diagnostics gabapentin immunoassay. ( Anderson, BL; Johnson-Davis, KL; Juenke, JM; McMillin, GA; Wienhoff, KA, 2011) |
| " The results indicate that pretreatment with Parawixin 10 prevents the onset of seizures induced with kainic acid, N-methyl-D-aspartate, and pentylenetetrazole in a dose-response manner." | 3.77 | Neurobiological activity of Parawixin 10, a novel anticonvulsant compound isolated from Parawixia bistriata spider venom (Araneidae: Araneae). ( Beleboni, RO; Coutinho-Netto, J; Cunha, AO; dos Santos, WF; Fachim, HA; Gobbo-Neto, L; Lopes, NP; Pereira, AC, 2011) |
| "This study aims to determine the expression of Gamma-aminobutyric acid (GABA) following hypoxia in neonatal rats and explore how it may increase susceptibility to epilepsy later in life." | 3.77 | Downregulation of hippocampal GABA after hypoxia-induced seizures in neonatal rats. ( Li, K; Sun, W; Wang, Y; Xu, E; Xu, ZC; Zeng, W; Zhan, L, 2011) |
| "The present study was performed to investigate whether or not carvedilol (a beta-adrenoreceptor antagonist) potentiates the anticonvulsive activity of gabapentin against ICES (Increasing current electroshock) and PTZ (Pentylenetetrazole) induced seizures in mice." | 3.77 | Influence of carvedilol on anticonvulsant effect of gabapentin. ( Goel, A; Goel, R; Kumar, Y, 2011) |
| "To evaluate the effects of high-frequency electrical stimulation (HFS) in both ventral hippocampi, alone and combined with a subeffective dose of antiepileptic drugs, during the status epilepticus (SE) induced by lithium-pilocarpine (LP)." | 3.76 | Antiepileptic drugs combined with high-frequency electrical stimulation in the ventral hippocampus modify pilocarpine-induced status epilepticus in rats. ( Alcantara-Gonzalez, D; Cuellar-Herrera, M; Neri-Bazan, L; Peña, F; Rocha, L, 2010) |
| "This study compared the potencies of epidurally delivered muscimol, lidocaine, midazolam, pentobarbital and gamma-aminobutyric acid (GABA) to prevent focal neocortical seizures induced by locally applied acetylcholine (Ach), in rats (n=5)." | 3.76 | Comparison of the antiepileptic properties of transmeningeally delivered muscimol, lidocaine, midazolam, pentobarbital and GABA, in rats. ( Baptiste, SL; Devinsky, O; French, JA; Kuzniecky, RI; Ludvig, N; Tang, HM, 2010) |
| " SRA880 did not affect seizure severity and did not reverse the anticonvulsive action of SRIF-14 (1 microM) against pilocarpine-induced seizures, suggesting that hippocampal sst(1) receptors are not involved in the anticonvulsive effects of SRIF-14." | 3.76 | Hippocampal sst(1) receptors are autoreceptors and do not affect seizures in rats. ( Aourz, N; Clinckers, R; De Bundel, D; Hoyer, D; Kastellakis, A; Kiagiadaki, F; Michotte, Y; Smolders, I; Thermos, K, 2010) |
| "Pre-treatment with GABA (40 mg/kg), diazepam, phenobarbital, AOAA and DABA abolished the appearance of seizures induced by 50 mg/kg (PhSe)₂ in rat pups." | 3.76 | Diphenyl diselenide-induced seizures in rat pups: possible interaction with GABAergic system. ( Nogueira, CW; Prigol, M; Wilhelm, EA; Zeni, G, 2010) |
| " Inhibitory gamma-aminobutyric acid (GABA) and excitatory N-methyl-D-aspartate (NMDA) systems play a role in the effect of stimulants in the genesis of epileptic seizures." | 3.76 | Effect of cross-fostering on seizures in adult male offspring of methamphetamine-treated rat mothers. ( Bernásková, K; Hrubá, L; Matejovská, I; Rokyta, R; Slamberová, R, 2010) |
| "We found that taurine-fed mice are resistant to picrotoxin-induced seizures when compared to age-matched controls, as measured by increased latency to seizure, decreased occurrence of seizures and reduced mortality rate." | 3.76 | Pharmacological characterization of GABAA receptors in taurine-fed mice. ( El Idrissi, A; L'Amoreaux, WJ; Marsillo, A, 2010) |
| "We suggest that the elevated threshold for picrotoxin-induced seizures in taurine-fed mice is due to the reduced binding sites available for picrotoxin binding due to the reduced expression of the beta subunits of the GABAA receptor." | 3.76 | Pharmacological characterization of GABAA receptors in taurine-fed mice. ( El Idrissi, A; L'Amoreaux, WJ; Marsillo, A, 2010) |
| " Here, we investigated pharmacologically the functional significance of decreased / or change in subunit composition of the GABAA receptors by determining the threshold for picrotoxin-induced seizures." | 3.76 | Pharmacological characterization of GABAA receptors in taurine-fed mice. ( El Idrissi, A; L'Amoreaux, WJ; Marsillo, A, 2010) |
| "Two-month-old male FVB/NJ mice were subcutaneously injected with picrotoxin (5 mg kg-1) and observed for a) latency until seizures began, b) duration of seizures, and c) frequency of seizures." | 3.76 | Pharmacological characterization of GABAA receptors in taurine-fed mice. ( El Idrissi, A; L'Amoreaux, WJ; Marsillo, A, 2010) |
| "Here we describe our experience with pregabalin (PGB); its effectiveness was retrospectively studied in nine consecutive patients with primary brain tumors and seizures." | 3.75 | Pregabalin in patients with primary brain tumors and seizures: a preliminary observation. ( Novy, J; Rossetti, AO; Stupp, R, 2009) |
| "To characterize the interactions between levetiracetam and the antiepileptic drugs gabapentin, tiagabine, and vigabatrin in suppressing pentylenetetrazole-induced clonic seizures in mice, type II isobolographic analysis was used." | 3.75 | Pharmacodynamic and pharmacokinetic interaction profiles of levetiracetam in combination with gabapentin, tiagabine and vigabatrin in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis. ( Andres-Mach, MM; Czuczwar, SJ; Dudra-Jastrzebska, M; Luszczki, JJ; Patsalos, PN; Ratnaraj, N; Sielski, M, 2009) |
| " The anticonvulsant actions of the extracted compounds were studied in pentylenetetrazole-induced clonic seizures in mice and their effect on motor coordination was studied using the rota-rod test in rats." | 3.75 | The role of polar phytocomplexes on anticonvulsant effects of leaf extracts of Lippia alba (Mill.) N.E. Brown chemotypes. ( Beleboni, RO; França, SC; Marques, MO; Neto, AC; Netto, JC; Pereira, AM; Pereira, PS; Taleb-Contini, SH, 2009) |
| "We have previously shown that intranigral transplants of immortalized GABAergic cells decrease the number of kainic acid-induced seizures [Castillo CG, Mendoza S, Freed WJ, Giordano M." | 3.74 | Intranigral transplants of a GABAergic cell line produce long-term alleviation of established motor seizures. ( Aguilar, MB; Castillo, CG; Freed, WJ; Giordano, M; Mendoza-Trejo, S, 2008) |
| " Using radioligand receptor-binding assay, we showed that only betulin bound to the GABA(A)-receptor sites in mice brain in vitro and antagonised the GABA(A)-receptor antagonist bicuculline-induced seizures in mice after intracisternal and intraperitoneal administration." | 3.74 | Betulin binds to gamma-aminobutyric acid receptors and exerts anticonvulsant action in mice. ( Dzirkale, Z; Klusa, V; Krigere, L; Mezhapuke, R; Muceniece, R; Rumaks, J; Saleniece, K; Zharkova, O, 2008) |
| "Abnormalities in the gamma-aminobutyric acid (GABA)-ergic system could be responsible for seizures in cortical dysplasia (CD)." | 3.74 | Pyramidal cell responses to gamma-aminobutyric acid differ in type I and type II cortical dysplasia. ( André, VM; Cepeda, C; Huynh, M; Levine, MS; Mathern, GW; Vinters, HV, 2008) |
| " Isobolographic analysis was used in two mouse experimental models of epilepsy: the maximal electroshock seizure threshold test and pentylenetetrazole-induced seizures." | 3.74 | Isobolographic and behavioral characterizations of interactions between vigabatrin and gabapentin in two experimental models of epilepsy. ( Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N, 2008) |
| " Oral administration of beta-acids (5-10mg/kg) in rats produced an increased exploratory activity in the open field, a reduction in the pentobarbital hypnotic activity and a worsening of picrotoxin-induced seizures." | 3.74 | Evidence that the beta-acids fraction of hops reduces central GABAergic neurotransmission. ( Avallone, R; Baraldi, M; Brusiani, F; Losi, G; Puia, G; Rivasi, M; Zanoli, P; Zavatti, M, 2007) |
| "The objective of this study was to characterize the anticonvulsant and acute adverse-effect potentials of topiramate (TPM) and gabapentin (GBP)-two second-generation antiepileptic drugs administered alone and in combination in the maximal electroshock (MES)-induced seizures and chimney test in mice." | 3.74 | Isobolographic analysis of interaction between drugs with nonparallel dose-response relationship curves: a practical application. ( Luszczki, JJ, 2007) |
| "We investigated efficacy of prolonged intraventricular gabapentin (GBP) infusion in the rat flurothyl epilepsy model." | 3.74 | Intraventricular administration of gabapentin in the rat increases flurothyl seizure threshold. ( Fisher, RS; Kraus, AC; Oommen, J, 2007) |
| " After 5 days of GBP infusion, seizures were induced by flurothyl dripped onto filter paper." | 3.74 | Intraventricular administration of gabapentin in the rat increases flurothyl seizure threshold. ( Fisher, RS; Kraus, AC; Oommen, J, 2007) |
| "GBP instilled into the lateral ventricles by pump for 5 days delays onset of generalized tonic-clonic seizures produced by flurothyl in the rat." | 3.74 | Intraventricular administration of gabapentin in the rat increases flurothyl seizure threshold. ( Fisher, RS; Kraus, AC; Oommen, J, 2007) |
| " By contrast, offspring of rats exposed to carbamazepine (which at the dose used produced low plasma concentrations) or to generalized convulsive seizures showed no clear-cut evidence of dysplasias." | 3.74 | Fetal exposure to GABA-acting antiepileptic drugs generates hippocampal and cortical dysplasias. ( Ben-Ari, Y; Depaulis, A; Jorquera, I; Manent, JB; Mazzucchelli, I; Perucca, E; Represa, A, 2007) |
| "Methylmalonic acid (MMA) is an endogenous convulsing compound that accumulates in methylmalonic acidemia, an inborn error of the metabolism characterized by severe neurological dysfunction, including seizures." | 3.74 | Convulsions induced by methylmalonic acid are associated with glutamic acid decarboxylase inhibition in rats: a role for GABA in the seizures presented by methylmalonic acidemic patients? ( Fighera, MR; Garrido-Sanabria, ER; Malfatti, CR; Mello, CF; Muller, AP; Paquetti, L; Perry, ML; Rigo, FK; Schweigert, ID, 2007) |
| " As part of a systematic effort to identify the optimal compounds and protocols for such a therapy, this study aimed to determine whether transmeningeal gamma-aminobutyric acid (GABA) delivery can terminate and/or prevent neocortical seizures in rats." | 3.74 | Transmeningeal delivery of GABA to control neocortical seizures in rats. ( Baptiste, SL; Devinsky, O; John, JE; Kuzniecky, RI; Ludvig, N; Sheffield, LG; von Gizycki, H, 2007) |
| "This work was designed to study the influence of drugs during seizures and status epilepticus (SE) induced by pilocarpine and mortality in adult rats." | 3.74 | Study pharmacologic of the GABAergic and glutamatergic drugs on seizures and status epilepticus induced by pilocarpine in adult Wistar rats. ( Assis, MA; Fonteles, MM; Freitas, RL; Freitas, RM; Pereira, MB; Silva, RF; Takahashi, RN, 2007) |
| " Status epilepticus was evoked in mice by intra-amygdala kainic acid, causing cytochrome c release, processing of caspases 9 and 7, and death of ipsilateral hippocampal pyramidal neurons." | 3.74 | Bcl-w protects hippocampus during experimental status epilepticus. ( Bellver-Estelles, C; Chu, X; Dicker, P; Dunleavy, M; Hatazaki, S; Henshall, D; Koegel, I; Meller, R; Murphy, B; Prehn, J; Schindler, C; Shinoda, S; Simon, R; Wang, W; Xiong, Z; Yamamoto, A, 2007) |
| " We report that application of 4-aminopyridine (4-AP) to immature (P6-P9) neocortical slices generates layer-specific interictal seizures (IISs) that transform after recurrent seizures to ictal seizures (ISs)." | 3.74 | Layer-specific generation and propagation of seizures in slices of developing neocortex: role of excitatory GABAergic synapses. ( Ben-Ari, Y; Represa, A; Rheims, S; Zilberter, Y, 2008) |
| "5 hours later by administration of saline vehicle or a regimen of bicuculline (1 mg/kg, sc), a GABA(A) receptor antagonist, which does not produce any intrinsic effects on seizures." | 3.73 | Actions at GABA(A) receptors in the hippocampus may mediate some antiseizure effects of progestins. ( Frye, CA; Rhodes, ME, 2005) |
| "The effects of carnosine (beta-alanyl-L-histidine) on amygdaloid-kindled seizures were investigated in rats." | 3.73 | Effects of carnosine on amygdaloid-kindled seizures in Sprague-Dawley rats. ( Chen, Z; Ding, MP; Fan, YY; Jin, CL; Li, Q; Luo, JH; Wu, XH; Yang, LX; Zhang, WP, 2005) |
| " Anticonvulsant and acute neurotoxic adverse effect profiles of combinations of GBP and TGB with other AEDs at fixed ratios of 1:3, 1:1 and 3:1 were investigated in pentylenetetrazole (PTZ)-induced seizures and the chimney test (as a measure of motor impairment) in mice so as to identify optimal combinations." | 3.73 | Isobolographic characterisation of interactions among selected newer antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model. ( Czuczwar, SJ; Luszczki, JJ, 2005) |
| "To assess whether there is a change in seizure activity in dogs with refractory epilepsy that are receiving appropriate doses of phenobarbitone and/or potassium bromide, when gabapentin is added to the therapeutic regimen." | 3.73 | Improving seizure control in dogs with refractory epilepsy using gabapentin as an adjunctive agent. ( Govendir, M; Malik, R; Perkins, M, 2005) |
| "Repeated systemic administration of low doses of kainic acid (KA) induces spontaneous convulsive seizures [Hellier JL, Patrylo PR, Buckmaster PS, Dudek FE." | 3.73 | Intranigral transplants of immortalized GABAergic cells decrease the expression of kainic acid-induced seizures in the rat. ( Castillo, CG; Freed, WJ; Giordano, M; Mendoza, S, 2006) |
| " Pilocarpine-induced status epilepticus (SE) was chosen as a model to generate chronic epileptic animals." | 3.73 | Septal GABAergic neurons are selectively vulnerable to pilocarpine-induced status epilepticus and chronic spontaneous seizures. ( Banuelos, C; Castañeda, MT; Colom, LV; Garrido Sanabria, ER; Hernandez, S; Perez-Cordova, MG, 2006) |
| "Limbic seizures were evoked in freely moving rats by intrahippocampal administration of pilocarpine via a microdialysis probe." | 3.73 | Substantia nigra is an anticonvulsant site of action of topiramate in the focal pilocarpine model of limbic seizures. ( Clinckers, R; Ebinger, G; Meurs, A; Michotte, Y; Smolders, I, 2006) |
| "Systemic and intranigral, but not intrahippocampal TPM administration suppressed pilocarpine-induced seizures and neurochemical changes." | 3.73 | Substantia nigra is an anticonvulsant site of action of topiramate in the focal pilocarpine model of limbic seizures. ( Clinckers, R; Ebinger, G; Meurs, A; Michotte, Y; Smolders, I, 2006) |
| "This work was designed to study the influence of drugs during seizures and status epilepticus (SE) induced by pilocarpine and mortality in adult rats." | 3.73 | Effect of gabaergic, glutamatergic, antipsychotic and antidepressant drugs on pilocarpine-induced seizures and status epilepticus. ( Fonteles, MM; Freitas, RM; Sousa, FC; Viana, GS, 2006) |
| " Heterozygous ADNFLE mutant mice show persistent, abnormal cortical electroencephalograms with prominent delta and theta frequencies, exhibit frequent spontaneous seizures, and show an increased sensitivity to the proconvulsant action of nicotine." | 3.73 | Seizures and enhanced cortical GABAergic inhibition in two mouse models of human autosomal dominant nocturnal frontal lobe epilepsy. ( Boulter, J; Glykys, J; Klaassen, A; Labarca, C; Maguire, J; Mody, I, 2006) |
| "Acute cocaine toxicity is frequently associated with seizures." | 3.73 | Cocaine inhibition of GABA(A) current: role of dephosphorylation. ( Ren, J; Ye, JH, 2006) |
| " This study shows that substitution on the N-terminus confers the greatest antiseizure activity, particularly against pilocarpine-induced seizures." | 3.72 | N-, alpha-, and beta-Substituted 3-Aminopropionic acids: design, syntheses and antiseizure activities. ( Tan, CY; Wainman, D; Weaver, DF, 2003) |
| " Mice which underwent 10 s but not 5 s seizures episode subsequently exhibited significantly increased seizure susceptibility to low doses (equal ED(16)) of bicuculline (BCC) and NMDA during a 3-week observation period." | 3.72 | The epileptogenic effect of seizures induced by hypoxia: the role of NMDA and AMPA/KA antagonists. ( Rubaj, A; Sieklucka-Dziuba, M; Zgodziński, W, 2003) |
| " Anticonvulsant effects were evaluated against seizures induced by both 14 mg/kg of 4-aminopyridine and 110 mg/kg of pentylenetetrazole, and neurotoxic effects were evaluated by the rotarod test." | 3.72 | Synergistic interaction between felbamate and lamotrigine against seizures induced by 4-aminopyridine and pentylenetetrazole in mice. ( Armijo, JA; Bravo, J; Cuadrado, A, 2003) |
| "Seizures were induced in rats by intraperitoneal injection of pentylenetetrazole (PTZ, 70 mg/kg), followed, 30 min later, by injection of [1-13C]glucose and [1,2-13C]acetate." | 3.72 | Pentylenetetrazole decreases metabolic glutamate turnover in rat brain. ( Dahl, CB; Eloqayli, H; Götestam, KG; Hadidi, H; Sonnewald, U; Unsgård, G, 2003) |
| " Anticonvulsant effects were evaluated against seizures induced by 14 mg kg(-1) of 4-aminopyridine (4-AP) and by 110 mg kg(-1) of pentylenetetrazole (PTZ), and neurotoxicity by the rotarod test." | 3.72 | Is the interaction between felbamate and valproate against seizures induced by 4-aminopyridine and pentylenetetrazole in mice beneficial? ( Amat, G; Armijo, JA; Cuadrado, A, 2003) |
| " Intrahippocampal mGluR group I agonist perfusion via a microdialysis probe [1 mm (R,S)-3,5-dihydroxyphenylglycine] induced seizures and concomitant augmentations in amino acid dialysate levels." | 3.72 | In vivo modulation of extracellular hippocampal glutamate and GABA levels and limbic seizures by group I and II metabotropic glutamate receptor ligands. ( Clinckers, R; Ebinger, G; Lindekens, H; Lodge, D; Meurs, A; Michotte, Y; O'Neill, MJ; Smolders, I, 2004) |
| " The relationships between Gln, Glu and GABA were studied under lead (Pb) toxicity conditions using synaptosomal fractions obtained from adult rat brains to investigate the cause of Pb neurotoxicity-induced seizures." | 3.72 | Relationships between glutamine, glutamate, and GABA in nerve endings under Pb-toxicity conditions. ( Struzyńska, L; Sulkowski, G, 2004) |
| " The present study was undertaken to examine the role of ALLO in the anticonvulsant action of fluoxetine against pentylenetetrazole (PTZ)-induced seizures in mice." | 3.72 | Essentiality of central GABAergic neuroactive steroid allopregnanolone for anticonvulsant action of fluoxetine against pentylenetetrazole-induced seizures in mice. ( Chopde, CT; Hirani, K; Mittal, N; Ugale, RR, 2004) |
| "Cefoselis is a widely used beta-lactam antibiotic, but occasionally induces seizures and convulsion in elder and renal failure patients." | 3.72 | Cefoselis, a beta-lactam antibiotic, easily penetrates the blood-brain barrier and causes seizure independently by glutamate release. ( Awaya, T; Chiba, K; Fujimaru, S; Hayase, N; Matsubara, K; Ohtaki, K; Shimizu, K; Shiono, H; Suno, M, 2004) |
| " In the present study, we used in vivo microdialysis to measure the levels of extracellular GABA (gamma-aminobutyric acid) and glutamate during seizure development in rats with a genetic predisposition for (Fast), or against (Slow), amygdala kindling." | 3.71 | Changes in extracellular levels of amygdala amino acids in genetically fast and slow kindling rat strains. ( Anisman, H; McIntyre, DC; Merali, Z; Shin, RS, 2002) |
| " longiflorus (CLE) was investigated for sedative, anticonvulsant and behaviour modifying activity using thiopental sleeping, caffeine induced convulsion and forced swimming depression tests." | 3.71 | Sedative, anticonvulsant and behaviour modifying effects of Centranthus longiflorus ssp. longiflorus: a study of comparison to diazepam. ( Büyükokuroğlu, ME; Demirezer, LO; Güvenalp, Z, 2002) |
| "Gabapentin (GBP) is a gamma-aminobutyric acid analog effective in the treatment of seizures." | 3.71 | Long-term regulation of voltage-gated Ca(2+) channels by gabapentin. ( Campbell, KP; Felix, R; Kang, MG, 2002) |
| " Chronic seizures were induced by amygdalar injection of kainic acid 60 days before death." | 3.71 | Collapse of extracellular glutamate regulation during epileptogenesis: down-regulation and functional failure of glutamate transporter function in rats with chronic seizures induced by kainic acid. ( Doi, T; Kamada, H; Mitsuyama, Y; Nakajima, A; Ohya-Nishiguchi, H; Tokumaru, J; Ueda, Y; Willmore, LJ; Yokoyama, H, 2001) |
| "To elucidate the relationship between stress and seizures, the effect of a single swim stress on the convulsive signs and death produced by several GABA-related and GABA-unrelated convulsants, and the effect of repeated swim stress on picrotoxin-induced convulsions was studied." | 3.71 | Swim stress alters the behavioural response of mice to GABA-related and some GABA-unrelated convulsants. ( Jazvinsćak, M; Mirković, K; Pericić, D; Svob, D, 2001) |
| "Several lines of evidence suggest that the binding affinity of glutamate decarboxylase (GAD) to the active form of pyridoxine is low in cases of pyridoxine-dependent seizures (PDS) and that a quantitative imbalance between excitatory (i." | 3.71 | CSF glutamate/GABA concentrations in pyridoxine-dependent seizures: etiology of pyridoxine-dependent seizures and the mechanisms of pyridoxine action in seizure control. ( Goto, T; Matsuo, N; Takahashi, T, 2001) |
| "5 mg/kg) were investigated in focally-evoked pilocarpine-induced (10 mM) seizures in freely moving rats." | 3.71 | 2-chloro-N(6)-cyclopentyladenosine-elicited attenuation of evoked glutamate release is not sufficient to give complete protection against pilocarpine-induced seizures in rats. ( Ebinger, G; Khan, GM; Michotte, Y; Smolders, I, 2001) |
| " Several of the novel compounds were also evaluated for their ability in vivo to inhibit clonic seizures induced by a 15 mg/kg (ip) dose of methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM)." | 3.71 | Synthesis of novel gamma-aminobutyric acid (GABA) uptake inhibitors. 5.(1) Preparation and structure-activity studies of tricyclic analogues of known GABA uptake inhibitors. ( Andersen, KE; Huusfeldt, PO; Lau, J; Lundt, BF; Petersen, H; Suzdak, PD; Swedberg, MD; Sørensen, JL, 2001) |
| "We examined the effects of regional infusions of 2-amino-7-phosphonoheptanoic acid (AP7) into the substantia nigra pars reticulata (SNR) in adult male rats on flurothyl-induced clonic seizures." | 3.71 | The effects of N-methyl-D-aspartate antagonist 2-amino-7-phosphonoheptanoic acid microinfusions into the adult male rat substantia nigra pars reticulata are site-specific. ( Hussain, S; Liptáková, S; Velísková, J, 2001) |
| "The relation between changes in the concentrations of some of the neuroactive extracellular amino acids (glutamate, aspartate, gamma-aminobutyric acid, glycine and taurine) and epileptic seizures has been tested in a new experimental model of seizures induced by picrotoxin microdialysis in chronic freely moving rats." | 3.70 | Extracellular amino acids in the rat hippocampus during picrotoxin threshold seizures in chronic microdialysis experiments. ( Aguilar-Veiga, E; Galán-Valiente, J; Mendez-Alvarez, E; Sierra-Marcuño, G; Sierra-Paredes, G; Soto-Otero, R; Vazquez-Illanes, MD, 1998) |
| "For the evaluation of glutamatergic and GABAergic transmission during seizures, rat hippocampal CA1 and CA3 areas were separately assessed by brain microdialysis, and extracelluar glutamate and GABA were measured through the course of the seizures after a systemic administration of kainic acid (KA)." | 3.70 | Changes in extracellular glutamate and GABA levels in the hippocampal CA3 and CA1 areas and the induction of glutamic acid decarboxylase-67 in dentate granule cells of rats treated with kainic acid. ( Asada, H; Ding, R; Obata, K, 1998) |
| "The effects of drugs affecting GABA and glutamic acid receptors on theophylline-induced seizures were investigated in mice." | 3.70 | Gamma-aminobutyric acid and glutamic acid receptors may mediate theophylline-induced seizures in mice. ( Amabeoku, GJ, 1999) |
| " For example, injection of the "indirect" excitotoxin aminooxyacetic acid (AOAA) into the EC of rats causes behavioral seizures and preferential loss of neurons in layer III of the medial EC." | 3.70 | Ultrastructure and immunocytochemical distribution of GABA in layer III of the rat medial entorhinal cortex following aminooxyacetic acid-induced seizures. ( Eid, T; Ottersen, OP; Schwarcz, R, 1999) |
| "The present study was undertaken to gain insights into the mechanism of action of diazepam in focally-evoked pilocarpine-induced seizures by concomitantly assessing the changes produced in the extracellular levels of glutamate, GABA (gamma-aminobutyric acid) and dopamine." | 3.70 | Effects of diazepam on extracellular brain neurotransmitters in pilocarpine-induced seizures in rats. ( Ebinger, G; Khan, GM; Lindekens, H; Manil, J; Michotte, Y; Smolders, I, 1999) |
| "Lidocaine is well known to have toxic effects on the central nervous system including the induction of electroencepharographic seizures and convulsions at high doses." | 3.70 | [Lidocaine increases the granule cell excitability in hippocampal dentate area instead of affecting GABAergic inhibition]. ( Ikeda, M; Maru, E; Shimada, M; Suzuki, H; Ueyama, T, 1999) |
| " We tested this hypothesis by examining the influence of gamma-aminobutyric acid (GABA) ergic and glutamatergic transmission in the NTS on seizures evoked by systemic and focal bicuculline and systemic pentylenetetrazol (PTZ) in rats." | 3.70 | Regulation of limbic motor seizures by GABA and glutamate transmission in nucleus tractus solitarius. ( Easton, A; Gale, K; Walker, BR, 1999) |
| "Muscimol in mNTS (but not in adjacent regions of NTS) attenuated seizures in all seizure models tested, whereas bicuculline methiodide into mNTS did not alter seizure responses." | 3.70 | Regulation of limbic motor seizures by GABA and glutamate transmission in nucleus tractus solitarius. ( Easton, A; Gale, K; Walker, BR, 1999) |
| "The effects of GABAmimetic drugs on inhibition of amygdaloid kindled seizures induced by clobenpropit were investigated to clarify the relationship between histaminergic and GABAergic systems in seizures." | 3.70 | Participation of GABAergic and histaminergic systems in inhibiting amygdaloid kindled seizures. ( Chen, Z; Fujii, Y; Ishizawa, K; Kamei, C; Okuma, C; Sugimoto, Y, 2000) |
| " Seizures were evoked with pilocarpine (400 mg/kg, i." | 3.70 | The effect of CGP-40116 on pilocarpine evoked seizures in mice exposed to transient episode of brain ischemia. ( Czuczwar, SJ; Kleinrok, Z; Rejdak, K; Rejdak, R; Sieklucka-Dziuba, M; Stelmasiak, Z, 2000) |
| "The purpose of the present investigation was to determine whether the sensitivity to systemic toxic effects of cocaine is altered in genetically epilepsy-prone rats (GEPRs)." | 3.70 | Phenotypic expression of the systemic toxicity of cocaine in genetically epilepsy-prone rats. ( Heavner, JE; Kao, YJ; Kaye, AD; Reigel, CE; Shi, B, 2000) |
| "Infusion of the K(+) channel blocker 4-aminopyridine in the hippocampus induces the release of glutamate, as well as seizures and neurodegeneration." | 3.70 | Seizures and neurodegeneration induced by 4-aminopyridine in rat hippocampus in vivo: role of glutamate- and GABA-mediated neurotransmission and of ion channels. ( Peña, F; Tapia, R, 2000) |
| "Multiple bilateral microinjections of 5 microg picrotoxin (antagonist of chloride channels coupled with GABAA receptors) into the globus pallidus induced lethal seizures in some rats and impaired conditioned avoidance responses in survivors." | 3.70 | Activation of neostriatal dopaminergic system in rats prevents toxic effects of picrotoxin administered into globus pallidus. ( Yakimovskii, A, 2000) |
| " The effects of some GABAergic and dopaminergic agents on pyrimethamine-induced tonic seizures were investigated in mice." | 3.69 | GABAergic and dopaminergic systems may be involved in seizures induced by pyrimethamine in mice. ( Amabeoku, G; Chikuni, O, 1994) |
| "Pyridoxine-dependent seizures are a disorder of GABA metabolism probably due to a defective binding of pyridoxal phosphate coenzyme (PALP) with glutamate decarboxylase (GAD), the rate-limiting enzyme in GABA synthesis." | 3.69 | Pyridoxine-dependent seizures associated with white matter abnormalities. ( Giugliani, R; Jardim, LB; Kliemann, FA; Martins, CE; Pires, RF; Vargas, CR; Vizioli, J, 1994) |
| "An abnormality in the pyridoxal-5'-phosphate (PLP) dependent enzyme, glutamic acid decarboxylase (GAD), which synthesizes gamma-aminobutyric acid (GABA), may underlie the epileptic syndrome of pyridoxine-dependent seizures." | 3.69 | Reduced GABA synthesis in pyridoxine-dependent seizures. ( Gospe, SM; Keen, CL; Olin, KL, 1994) |
| "To determine whether the substantia nigra GABAergic anticonvulsant effects depend on GABAB receptor activation, we tested the effects of intranigral CGP 35,348 (a GABAB receptor antagonist) alone or in combination with gamma-vinyl-GABA (GVG; a GABA-transaminase inhibitor) on flurothyl seizures in rat pups and adult rats." | 3.69 | Further evidence of involvement of substantia nigra GABAB receptors in seizure suppression in developing rats. ( Garant, DS; Moshé, SL; Velísková, J; Xu, SG, 1994) |
| " In the present study, we investigated the effects of GABAergic action on kainic acid (KA)-induced hippocampal seizure in rats with or without hippocampal sclerosis (HS)." | 3.69 | Altered GABAergic effects on kainic acid-induced seizures in the presence of hippocampal sclerosis in rats. ( Araki, T; Goto, I; Kato, M, 1994) |
| "The effects of muscimol, amino-oxyacetic acid (AOAA), diamino-N-butyric acid (DABA), bicuculline, picrotoxin, diazepam and phenobarbitone on the protective effect of clonidine against pentylenetetrazol-induced seizures were studied in mice." | 3.69 | gamma Aminobutyric acid mediation of the anticonvulsant effect of clonidine on pentylenetetrazol-induced seizures in mice. ( Amabeoku, G; Bwakura, E; Chikuni, O, 1994) |
| "There is a reduction of gamma-aminobutyric acid (GABA)-mediated inhibition of the CA1 pyramidal region of the hippocampus during status epilepticus (SE)." | 3.69 | Experimental status epilepticus alters gamma-aminobutyric acid type A receptor function in CA1 pyramidal neurons. ( Coulter, DA; Kapur, J, 1995) |
| "Gabapentin (GBP) is a new antiepileptic drug (AED) approved for adjunctive treatment of complex partial seizures with or without seizures secondarily generalization in adults." | 3.69 | Gabapentin associated with aggressive behavior in pediatric patients with seizures. ( Lo, W; Nahata, MC; Tallian, KB; Tsao, CY, 1996) |
| "To determine whether seizures have age-specific features, we studied the role of gamma-aminobutyric acidB (GABAB) transmission in rats of various ages (9, 15, 30, and 60 postnatal days)." | 3.69 | Age-specific effects of baclofen on pentylenetetrazol-induced seizures in developing rats. ( Moshé, SL; Velísek, L; Velísková, J, 1996) |
| "Fluoxetine, a serotonin (5-HT) reuptake inhibitor, has been documented to exert a protective action against convulsive seizures in animal models, when administered either systemically, or focally into substantia nigra." | 3.69 | The anticonvulsant action of fluoxetine in substantia nigra is dependent upon endogenous serotonin. ( Gale, K; Pasini, A; Tortorella, A, 1996) |
| "Cerebrospinal fluid (CSF) concentrations of glutamate and gamma- aminobutyric acid (GABA), as estimates of levels in the extracellular compartment of brain, were determined in 7-day postnatal rats at the terminus of hypoxia-ischemia and during status epilepticus, induced with bicuculline, at 2 and 24 h of recovery." | 3.69 | Cerebrospinal fluid concentrations of glutamate and GABA during perinatal cerebral hypoxia-ischemia and seizures. ( Cataltepe, O; Towfighi, J; Vannucci, RC, 1996) |
| " In adult rats, we determined the effects on flurothyl seizures of (Z)-3-[(aminoiminomethyl)thio]prop-2-enoic acid (ZAPA, a presumed agonist of the low-affinity GABAA receptor site), bicuculline (an antagonist of the low-affinity GABAA receptor site) and gamma-vinyl-GABA (a GABA-transaminase inhibitor), infused bilaterally in anterior or posterior substantia nigra pars reticulata." | 3.69 | Developmental regulation of regional functionality of substantial nigra GABAA receptors involved in seizures. ( Moshé, SL; Nunes, ML; Velísek, L; Velísková, J, 1996) |
| "Several similarities exist between the alterations observed in the chronic pilocarpine model of recurrent seizures in the rat and those found in human temporal lobe epilepsy." | 3.69 | Vulnerability and plasticity of the GABA system in the pilocarpine model of spontaneous recurrent seizures. ( Esclapez, M; Houser, CR, 1996) |
| "Limbic seizures were provoked in freely moving rats by intrahippocampal administration of the muscarinic receptor agonist pilocarpine via a microdialysis probe (10 mM for 40 min at 2 microliters/min)." | 3.69 | Hippocampal and cerebellar extracellular amino acids during pilocarpine-induced seizures in freely moving rats. ( Ebinger, G; Michotte, Y; Smolders, I; Van Belle, K, 1997) |
| " The effect of Ciprofloxacin was studied in electroconvulsive seizures in mice using the tonic extensor phase as end point and seizure threshold as observational parameter." | 3.69 | Interaction of ciprofloxacin with diclofenac and paracetamol in relation to it's epileptogenic effect. ( Makde, SD; Paranjpe, BD; Shrivastava, MP, 1997) |
| "The effects of valproate on CNS concentrations of gamma-aminobutyric acid (GABA), glulamate (GLU), glutamine (GLN); dopamine (DA), serotonin (5-HT), and metabolites were examined in tissue extracts of caudate nucleus of genetic substrains of Balb/c mice susceptible (EP) or resistant (ER) to audiogenic seizures." | 3.69 | Effects of valproate on amino acid and monoamine concentrations in striatum of audiogenic seizure-prone Balb/c mice. ( Alexiuk, NA; Vriend, JP, 1996) |
| "A case of a patient with medically intractable epilepsy, who developed obstructive sleep apnoea (OSA), and an increase in seizure frequency, as a consequence of weight gain following treatment with vigabatrin is described." | 3.69 | Obstructive sleep apnoea following rapid weight gain secondary to treatment with vigabatrin (Sabril). ( Bird, JM; Lambert, MV, 1997) |
| "The effects of three new antiepileptic drugs (felbamate, lamotrigine and gabapentin) on the parameters of seizure initiation and termination in one model of reverberatory seizures in the hippocampal-parahippocampal loop in urethane-anesthetized rats were determined." | 3.69 | Effects of felbamate, gabapentin and lamotrigine on seizure parameters and excitability in the rat hippocampus. ( Stringer, JL; Xiong, ZQ, 1997) |
| " Pilocarpine administration has been used as an animal model for temporal lobe epilepsy since it produces several morphological and synaptic features in common with human complex partial seizures." | 3.69 | NMDA receptor-mediated pilocarpine-induced seizures: characterization in freely moving rats by microdialysis. ( Ebinger, G; Khan, GM; Manil, J; Michotte, Y; Smolders, I, 1997) |
| "In the experiments carried out on Albino-Swiss mice it was found, that bilateral clamping of carotid arteries (BCCA) for 30 min produce the increase of GABA content in hippocampus, striatum and frontal cortex and decrease of the seizures susceptibility to bicuculline, investigated 7 days after surgery." | 3.69 | Influence of bilateral clamping of carotid arteries on the seizures susceptibility and central action of AOAA in mice. ( Józwiak, L; Kleinrok, Z; Sieklucka-Dziuba, M; Tokarski, R, 1996) |
| "The anticonvulsant topiramate is effective in laboratory animals against maximal electroshock seizures, amygdala kindling, and spike-wave discharges and has demonstrated efficacy in humans for the treatment of complex partial seizures." | 3.69 | Topiramate enhances GABA-mediated chloride flux and GABA-evoked chloride currents in murine brain neurons and increases seizure threshold. ( Brown, SD; Skeen, GA; White, HS; Wolf, HH; Woodhead, JH, 1997) |
| "The effects of repeated or a single generalised seizure on extracellular glutamate and gamma-aminobutyric acid (GABA) levels in the ventral hippocampus of the freely-moving rat were studied using maximal electroshock-induced seizures in conjunction with in vivo microdialysis." | 3.69 | Generalised seizure-induced changes in rat hippocampal glutamate but not GABA release are potentiated by repeated seizures. ( Marsden, CA; Martin, KF; Rowley, HL, 1997) |
| "The action of progabide against motor seizures elicited by pentylenetetrazol was studied in 7-, 12-, 18-, 25-day-old and adult rats." | 3.69 | Anticonvulsant effect of progabide in rats during ontogenesis. ( Kozuchová, A; Mares, P; Stanková, L, 1997) |
| "The N-4,4-diphenyl-3-butenyl derivative of the glial selective gamma-aminobutyric acid (GABA) uptake inhibitor 4,5,6,7-tetrahydroisoxazolo [4,5-c]pyridin-3-ol (N-DPB-THPO), was tested for its ability to block sound-induced seizures in the audiogenic seizure-susceptible Frings mouse model of epilepsy." | 3.68 | Anticonvulsant activity of the gamma-aminobutyric acid uptake inhibitor N-4,4-diphenyl-3-butenyl-4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol . ( Falch, E; Hunt, J; Krogsgaard-Larsen, P; Schousboe, A; Swinyard, EA; White, HS; Wolf, HH, 1993) |
| ") displaces [3H]flumazenil from its brain binding sites and in vivo it possesses a marked anticonflict profile in the rat Vogel conflict-punishment test and is 10 times more potent than bretazenil and 100 times more potent than diazepam or alprazolam in antagonizing bicuculline- and pentylenetetrazol-induced seizures." | 3.68 | Imidazenil: a new partial positive allosteric modulator of gamma-aminobutyric acid (GABA) action at GABAA receptors. ( Arban, R; Costa, E; Ducić, I; Giusti, P; Guidotti, A; Puia, G; Walser, A, 1993) |
| "The behavioral and convulsant effects of cefazolin, a beta-lactam derivative, were studied after intraperitoneal administration to DBA/2 mice, a strain genetically susceptible to sound-induced seizures, and Swiss mice." | 3.68 | Quinolones potentiate cefazolin-induced seizures in DBA/2 mice. ( Chimirri, A; De Sarro, A; De Sarro, GB; Grasso, S; Zappalá, M, 1993) |
| "The alpha 2-antagonist, yohimbine has been shown to dose-dependently induce clonic seizures in mice." | 3.68 | Yohimbine-induced seizures involve NMDA and GABAergic transmission. ( Corbett, R; Dunn, RW, 1992) |
| " The purpose of this study was to test the hypothesis that a short period of hypoxia would affect release of excitatory and inhibitory amino acids during subsequent bicuculline-induced seizure." | 3.68 | Hypoxia increases extracellular concentrations of excitatory and inhibitory neurotransmitters in subsequently induced seizure: in vivo microdialysis study in the rabbit. ( Aquila, WJ; During, MJ; Ley, E; Tendler, D; Young, RS, 1992) |
| " (ED50 and ED85 doses, respectively, for inhibiting pentylenetetrazole-induced tonic seizures)." | 3.68 | The gamma-aminobutyric acid (GABA) uptake inhibitor, tiagabine, increases extracellular brain levels of GABA in awake rats. ( Fink-Jensen, A; Hansen, L; Judge, ME; Nielsen, PG; Suzdak, PD; Swedberg, MD, 1992) |
| "In an infant with typical pyridoxine-dependent seizures, CSF GABA level, was determined before treatment with pyridoxine." | 3.68 | Disturbance of GABA metabolism in pyridoxine-dependent seizures. ( Bömelburg, T; Grüneberg, M; Kurlemann, G; Palm, DG; Ullrich, K; Ziegler, R, 1992) |
| " In vivo, NNC-711 was a potent anticonvulsant compound against rodent seizures induced by methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM) (ED50 (clonic) = 1." | 3.68 | NNC-711, a novel potent and selective gamma-aminobutyric acid uptake inhibitor: pharmacological characterization. ( Andersen, KE; Frederiksen, K; Knutsen, LJ; Nielsen, EB; Suzdak, PD; Sørensen, PO, 1992) |
| "Immature rats are more susceptible to clonic seizures induced by aminooxyacetic acid (AOAA) than mature and senile rats." | 3.68 | Age dependency of the susceptibility of rats to aminooxyacetic acid seizures. ( Cavalheiro, EA; Dziki, M; Kleinrok, Z; Parada, J; Turski, W, 1992) |
| " The influence of some GABAergic agents on tonic seizures elicited by chloroquine was investigated in mice." | 3.68 | Involvement of GABAergic mechanisms in chloroquine-induced seizures in mice. ( Amabeoku, G, 1992) |
| " Similarly, following pretreatment with intranigral isoniazid, neither severity nor latency to onset of seizures elicited by systemic injection of kainic acid (9 mg/kg) were modified." | 3.68 | Lack of proconvulsant action of GABA depletion in substantia nigra in several seizure models. ( Gale, K; Maggio, R; Sohn, E, 1991) |
| "Medetomidine, a new selective alpha 2-adrenoceptor agonist, potentiated bicuculline seizures in mice." | 3.68 | The effect of medetomidine on GABA and benzodiazepine receptors in vivo: lack of anxiolytic but some evidence of possible stress-protective activity. ( Airaksinen, MM; MacDonald, E; Rägo, L; Saano, V, 1991) |
| " When tested for sensitivity to the convulsant actions of GABAergic antagonists, picrotoxin produced seizures at lower doses in CBA as compared to NMRI and C57 mice, whereas there was no difference between the strains in the seizure activity produced by the specific GABA receptor antagonist bicuculline." | 3.68 | Evidence that genetic differences in habituation and GABAergic mechanisms may be related to sensitivity to ethanol and development of ethanol tolerance in mice. ( Liljequist, S, 1991) |
| " Its anticonvulsant effects against 3-mercaptopropionic acid (MPA)-induced seizures in mice is related to the elevation of whole brain GABA concentrations: The mentioned doses of MDL 72483 which cause a decrease of GABA-T activity by 50%, produce within 5 h after dosing an increase of GABA concentration by about 3 mumol." | 3.68 | (4S)-4-amino-5,6-heptadienoic acid (MDL 72483): a potent anticonvulsant GABA-T inhibitor. ( Casara, P; Knödgen, B; Sarhan, S; Seiler, N, 1991) |
| "Appearances of pentetrazole-, picrotoxin- and strychnine-induced convulsive seizures in taurine-deficient mice produced by treatment with guanidinoethyl sulfonate (GES), a taurine transport antagonist, were investigated." | 3.68 | [Drug-induced seizures in taurine-deficient mice]. ( Araki, H; Sano, M; Shimada, C; Tanaka, S, 1991) |
| " The anticonvulsant activity of tiagabine was evaluated against seizures induced by methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM), pentylenetetrazol, bicuculline, maximal electrostimulation (MES), or high intensity sound." | 3.68 | Characterization of tiagabine (NO-328), a new potent and selective GABA uptake inhibitor. ( Andersen, KE; Braestrup, C; Knutsen, LJ; Nielsen, EB; Sonnewald, U; Suzdak, PD, 1991) |
| " Local hippocampal administration of gamma-aminobutyric acid (GABA) resulted in neuronal recovery from domoic acid-induced seizures." | 3.68 | Domoic acid induced seizure activity in rats. ( Dakshinamurti, K; Sharma, SK; Sundaram, M, 1991) |
| "In the present study glutamate decarboxylase immunoreactivity (GAD-IR) was used to quantify GABAergic neurons in the hippocampus of rats exhibiting spontaneous recurrent seizures following pilocarpine-induced status epilepticus." | 3.68 | GAD-immunoreactive neurons are preserved in the hippocampus of rats with spontaneous recurrent seizures. ( Cavalheiro, EA, 1990) |
| " Metabolic changes associated with kainic acid seizures predominate in the hippocampus, where there are decreases in aspartate (-26%), glutamate (-45%), taurine (-20%), and glutamine (-32%) concentrations and an increase in gamma-aminobutyric acid (GABA) concentration (+ 26%)." | 3.67 | Changes in regional neurotransmitter amino acid levels in rat brain during seizures induced by L-allylglycine, bicuculline, and kainic acid. ( Chapman, AG; Meldrum, BS; Premachandra, M; Westerberg, E, 1984) |
| " Catecholamines, to a lesser extent the indolamine, serotonin, and the inhibitory transmitter gamma-aminobutyric acid all alter seizures as do less well understood intrinsic hormones and pentapeptides." | 3.67 | Evidence for neurotransmitter abnormalities related to seizure activity in the epileptic baboon. ( Killam, EK; Killam, KF, 1984) |
| "A detailed case history of lead poisoning in a young infant is presented." | 3.67 | Lead-induced convulsions in young infants--a case history and the role of GABA and sodium valproate in the pathogenesis and treatment. ( Aslam, M; Fernando, NP; Harrison, PG; Healy, MA, 1984) |
| "25 mg/kg produced partial protection against 3-mercaptopropionic acid (MPA)-induced seizures." | 3.67 | Synergistic anticonvulsant effects of a GABA agonist and glycine. ( Sarhan, S; Seiler, N, 1984) |
| "n-Alkyl esters of nipecotic acid were prepared by Fischer esterification, and the esters were evaluated against bicuculline-induced seizures in mice." | 3.67 | gamma-Aminobutyric acid uptake inhibition and anticonvulsant activity of nipecotic acid esters. ( Crider, AM; Hinko, CN; Seibert, K; Tschappat, KD; Wood, JD, 1984) |
| " Picrotoxin and pentylenetrazol-induced seizures were also blocked with corresponding ED50 values for clonic convulsions of 224." | 3.67 | Anticonvulsant activity of the nipecotic acid ester, (+/-)-m-nitrophenyl-3-piperidinecarboxylate. ( Crider, AM; Hinko, CN; Seibert, K, 1984) |
| " We determined the role of gamma-aminobutyric acid (GABA)ergic activity of the SN and the target sites of SN efferents, the pedunculopontine nucleus (PPN) and superior colliculus (SC), in pentylenetetrazol-induced seizures in rats." | 3.67 | The role of the nigrotegmental GABAergic pathway in the propagation of pentylenetetrazol-induced seizures. ( Nagaya, H; Negishi, N; Okada, R, 1989) |
| " GSH and its related aminoacids as cysteine and glycine greatly decreased the duration of INH-induced seizures, while glutamic acid did not protect against convulsions caused by INH." | 3.67 | Anti-convulsant effects by reduced glutathione and related aminoacids in rats treated with isoniazid. ( Colombo-Zefinetti, G; Pinelli, A; Tofanetti, O; Trivulzio, S, 1988) |
| ") to mice, had only a marginal protective effect against seizures induced 1 hr later by 3-mercaptopropionic acid (MPA)." | 3.67 | Amplification by glycine of the anticonvulsant effect of THPO, a GABA uptake inhibitor. ( Hjeds, H; Krogsgaard-Larsen, P; Sarhan, S; Schousboe, A; Seiler, N, 1985) |
| "The interaction between pentobarbital and other modulators of GABAergic transmission (diazepam, ethanol and progabide) was investigated on maximal electroshock seizures and on the loss of righting reflexes in rats." | 3.67 | Involvement of a GABAergic mechanism in the anticonvulsant effect of pentobarbital against maximal electroshock-induced seizures in rats. ( Rastogi, SK; Ticku, MK, 1985) |
| "The effects of three specific GABA receptor agonists, muscimol, progabide, and gaboxadol, on kindled seizures were evaluated in amygdala-kindled rats." | 3.67 | Evaluation of different GABA receptor agonists in the kindled amygdala seizure model in rats. ( Löscher, W; Schwark, WS, 1985) |
| " Our studies indicate that long-term exposure to diazepam results in: (1) a decrease in iontophoretic sensitivity to GABA in the dorsal raphe nucleus, (2) an increase in the affinity of the GABA recognition site in brain tissue and (3) an increase in susceptibility to bicuculline-induced seizures in the intact animal." | 3.67 | Continuous release of diazepam: electrophysiological, biochemical and behavioral consequences. ( Anderson, SA; Gallager, DW; Gonsalves, SF; Malcolm, AB, 1985) |
| "Lysine and its metabolic intermediates were studied for their effect on pentylenetetrazol (PTZ)-induced seizures in mice." | 3.67 | Effects of L-lysine and its metabolites on pentylenetetrazol-induced seizures. ( Chang, YF; Myslinski, NR, 1985) |
| "Repeated administration of the beta-carboline benzodiazepine receptor ligand FG 7142 produces sensitization to its effects so that full seizures develop (chemical kindling); initially it is only pro-convulsant." | 3.67 | The effects of drugs acting at the GABAA-receptor/ionophore after chemical kindling with the benzodiazepine receptor ligand FG 7142. ( Little, HJ; Nutt, DJ; Taylor, SC, 1986) |
| " A significant sensitization to seizures induced by isoniazid, a drug known to inhibit GABAergic transmission, was also found to occur after long-term (25 days) withdrawal." | 3.67 | Behavioural and biochemical evidence for a long-lasting decrease in GABAergic function elicited by chronic administration of FG 7142. ( Biggio, G; Corda, MG; Giorgi, O, 1986) |
| "The persistence of benzodiazepine antagonists in reversing neuronal and behavioral tolerance during chronic diazepam exposure was examined in rodents by investigating the time course for antagonist-induced alterations in iontophoretic sensitivity to gamma-aminobutyric acid on dorsal raphe neurons and the re-emergence of anticonvulsant efficacy to bicuculline-induced seizures." | 3.67 | Persistent reversal of tolerance to anticonvulsant effects and GABAergic subsensitivity by a single exposure to benzodiazepine antagonist during chronic benzodiazepine administration. ( Gallager, DW; Gonsalves, SF, 1988) |
| "The effects of intraamygdala injections of either gamma-vinyl GABA or muscimol on the behavioral and electrographic expression of stable, fully generalized, kindled seizures were assessed." | 3.67 | Microinjections of GABA agonists into the amygdala complex attenuates kindled seizure expression in the rat. ( Applegate, CD; Burchfiel, JL, 1988) |
| "The effects of progabide, a direct gamma-aminobutyric acid (GABA) receptor agonist, on bicuculline-induced seizures have been tested in developing rats, ages 7-28 days, to study the correlation between the antiepileptic effectiveness of this drug and the level of functional maturation of the GABAergic system." | 3.67 | Effects of progabide on bicuculline-induced epileptic seizures in developing rats. ( de Feo, MR; Mecarelli, O; Ricci, GF; Rina, MF, 1988) |
| "Differences in resistance to 3-mercaptopropionic acid (MP)-induced seizures exist between DBA/2Ibg and C57BL/6Ibg inbred strains of mice; C57BL/6Ibg mice are more resistant to MP-induced seizures." | 3.67 | Classical genetic analysis of GABA-related seizures. ( Marley, RJ; Martin, BJ; Miner, LL; Wehner, JM, 1988) |
| " The GABA-T inhibitor dose-dependently protected mice against isoniazid-induced seizures, simultaneously causing an increase in brain GABA concentrations." | 3.67 | Gamma-vinyl GABA: comparison of neurochemical and anticonvulsant effects in mice. ( Bernasconi, R; Christen, P; Hafner, T; Klein, M; Martin, P; Portet, C; Schmutz, M, 1988) |
| "Microinjection of gamma-vinyl GABA (GVG), a GABA elevating agent, into a discrete region of the deep prepiriform cortex elevated local GABA levels nearly 4-fold and exerted an anticonvulsant action against seizures induced by intravenous injection of the GABA antagonist, bicuculline, but was ineffective against seizures induced by maximal electroshock." | 3.67 | Anticonvulsant effects of GABA elevation in the deep prepiriform cortex. ( Gale, K; Pavlick, M; Piredda, S, 1987) |
| "The turnover rates and steady-state levels of gamma-aminobutyric acid (GABA) have been determined in 15 brain areas of three sublines of inbred mice differing in their susceptibility to audiogenic seizures: Rb3, which is seizure resistant; Rb2, which develops clonic seizures; and Rb1, which develops tonic-clonic seizures." | 3.67 | Effect of repeated convulsive seizures on brain gamma-aminobutyric acid metabolism in three sublines of mice differing by their response to acoustic stimulations. ( Ciesielski, L; Clement, J; Mandel, P; Simler, S, 1987) |
| " In this study, seizures were observed in mice treated with MMT in propylene glycol or corn oil." | 3.67 | Neurotoxic effects of methylcyclopentadienyl manganese tricarbonyl (MMT) in the mouse: basis of MMT-induced seizure activity. ( Fishman, BE; Gianutsos, G; McGinley, PA, 1987) |
| "1 The release of endogenous gamma-aminobutyric acid (GABA) from slices of rat cortex, hippocampus and striatum prepared both 30 min and 24 h after the last of a series of electroconvulsive shocks (5 seizures given spread out over 10 days) has been investigated." | 3.67 | The effect of repeated electroconvulsive shock on GABA synthesis and release in regions of rat brain. ( Green, AR; Vincent, ND, 1987) |
| "Amino acid concentrations were measured in the cortex, cerebellum and hippocampus of the mouse brain before and during seizures induced by isoniazid (250 mg/kg i." | 3.67 | The specific protective effect of diazepam and valproate against isoniazid-induced seizures is not correlated with increased GABA levels. ( Baltzer, V; Bernasconi, R; Jones, RS; Klein, M; Maître, L; Martin, P; Portet, C; Schmutz, M, 1985) |
| " injection of bicuculline (4, 6 or 8 mg/kg) and were immediately tested for latency to initial myoclonic jerk and clonus." | 3.67 | Coping and seizure susceptibility: control over shock protects against bicuculline-induced seizures. ( Alpern, HP; Drugan, RC; Maier, SF; McIntyre, TD, 1985) |
| "The anticonvulsant efficacy of the GABAmimetic drugs cetyl GABA, progabide and THIP (4,5,6,7-tetrahydroisoxazolo [5,4-c] pyridine-3-ol) was studied against minor (myoclonic) and major (generalized tonic-clonic) seizures in gerbils as well as against maximal electroshock and s." | 3.67 | Anticonvulsant action of GABA agonists and prodrugs on minor and major seizures in epileptic gerbils. Comparison with mouse models of seizure states. ( Löscher, W, 1985) |
| " The onset of generalized seizures induced by isoniazid (800 mg/kg) or by thiosemicarbazide (64 mg/kg) i." | 3.66 | Decreased convulsant potency of picrotoxin and pentetrazol and enhanced [3H]flunitrazepam cortical binding following stressful manipulations in rats. ( Hamon, M; Hery, F; Jobert, A; Montastruc, JL; Soubrie, P; Thiebot, MH, 1980) |
| "In rabbits, generalized seizures were induced by methoxypyridoxine, and changes in amino acid concentrations of 15 brain regions were investigated before seizure onset and during the course of sustained epileptiform activity." | 3.66 | Alterations in the content of amino acid neurotransmitters before the onset and during the course of methoxypyridoxine-induced seizures in individual rabbit brain regions. ( Haug, P; Nitsch, C; Schmude, B, 1983) |
| " Since electrophysiological and pharmacological data suggest the view that gamma-aminobutyric acid (GABA) plays an important role in controlling convulsive seizures, the effect of lindane on the GABAergic system, on different areas of the rat brain, has been evaluated." | 3.66 | Convulsions induced by lindane and the involvement of the GABAergic system. ( Cattabeni, F; Eli, M; Pastorello, MC, 1983) |
| "The properties of gamma-aminobutyric acid recognition sites, benzodiazepine binding sites and the effect of exogeneous gamma-aminobutyric acid on benzodiazepine binding were determined in crude membrane fractions prepared from the brains of DBA/2 mice at ages before (8-9 and 17-18 days), during (22-23 and 28-29 days) and after (40-43 days) the age of high susceptibility to audiogenic seizures." | 3.66 | gamma-Aminobutyric acid and benzodiazepine binding sites in audiogenic seizure-susceptible mice. ( Horton, RW; Meldrum, BS; Prestwich, SA, 1982) |
| "Phenibut, sodium hydroxybutyrate and baclofen are selectively effective against seizures induced in mice by the endogenous metabolites of tryptophan, L-kynurenine and quinolinic acid." | 3.66 | [Convulsions induced by kynurenine and quinolinic acid as a sensitive test for assessing the anticonvulsant activity of GABA-ergic preparations]. ( Lapin, IP; Ryzhov, IV, 1983) |
| "The onset of clonic seizures induced by 3-mercaptopropionic acid (MP) was associated with an approximately 200% increase of cAMP and a 70% elevation of cGMP in the mouse cerebral cortex." | 3.66 | Cyclic GMP and cyclic AMP in the cerebral cortex of mice during seizures induced by 3-mercaptopropionic acid: effects of anticonvulsant agents. ( Folbergrová, J, 1980) |
| "Intraperitoneal injection of ethanol (1-2 g/kg) and chlordiazepoxide (2-16 mg/kg) suppressed susceptibility to audiogenically induced, clonic-tonic seizures and antagonized forelimb tremor in rats undergoing ethanol withdrawal, 30 min after treatment." | 3.66 | Differential sensitivity of ethanol withdrawal signs in the rat to gamma-aminobutyric acid (GABA)mimetics: blockade of audiogenic seizures but not forelimb tremors. ( Breese, GR; Frye, GD; McCown, TJ, 1983) |
| "Ten analogues of valproic acid (substituted butyric, pentanoic and hexanoic acids) were tested for anticonvulsant activity against audiogenic seizures in DBA/2 mice." | 3.66 | Acute anticonvulsant activity of structural analogues of valproic acid and changes in brain GABA and aspartate content. ( Chapman, AG; Meldrum, BS; Mendes, E, 1983) |
| "Seven GABAmimetic drugs, namely cetyl gamma-aminobutyric acid (cetyl GABA), 4,5,6,7-tetrahydroisoxazolo [5,4-c]pyridine-3-ol, progabide, aminooxyacetic acid, alpha-acetylenic GABA, (-)-nipecotic acid ethyl ester and (+/-)-cis-4-hydroxynipecotic acid methyl ester, were tested for their potency to block "major" (generalized clonic-tonic) seizures in gerbils, induced by blowing at the animals with compressed air." | 3.66 | High anticonvulsant potency of gamma-aminobutyric acid (GABA)mimetic drugs in gerbils with genetically determined epilepsy. ( Frey, HH; Löscher, W; Reiche, R; Schultz, D, 1983) |
| "The effect of valproic acid and 10 close analogues (7 branched and 3 non-branched) were studied on the content of gamma-aminobutyric acid (GABA) in brain and on seizures induced by pentylenetetrazol (PTZ) in mice." | 3.66 | The effects of analogues of valproic acid on seizures induced by pentylenetetrazol and GABA content in brain of mice. ( Keane, PE; Mendes, E; Morre, M; Santucci, V; Simiand, J, 1983) |
| "The concentration of gamma-aminobutyrate (GABA) and the activity of glutamate decarboxylase and GABA-transaminase were measured in extracts of mouse brain before the onset and during the course of generalized seizures induced by systemic administration of homocysteine thiolactone." | 3.66 | Hippocampal electrical activity and gamma-aminobutyrate metabolism in brain tissue following administration of homocysteine. ( Dewhurst, IC; Griffiths, R; Hagan, JJ; Morris, RG, 1983) |
| "Pyridoxine-dependent seizures occur as a result of an increased requirement of the vitamin within the central nervous system." | 3.66 | Pyridoxine-dependent seizures. ( Crowell, GF; Roach, ES, 1983) |
| " During 1 h of bicuculline-induced seizures (1." | 3.66 | Cortical GABA turnover during bicuculline seizures in rats. ( Chapman, AG; Evans, MC, 1983) |
| "Pentylenetetrazole was administered to Swiss-Albino mice, producing clonic-tonic seizures." | 3.66 | Pentylenetetrazole induced changes in cerebellar energy metabolism. ( McCandless, DM; Schwartzenburg, FC, 1982) |
| " Blockade of tonic hindlimb extension in the maximal electroshock test and blockade of tonic and clonic seizures produced by pentylenetetrazole and bicuculline were obtained by elevating GABA in the ventral midbrain tegmentum." | 3.66 | Substantia nigra: site of anticonvulsant activity mediated by gamma-aminobutyric acid. ( Gale, K; Iadarola, MJ, 1982) |
| "d-Tubocurarine (dtc) administered intracerebroventricularly (icv) to rats produced seizures." | 3.66 | Antagonism of some central effects of d-tubocurarine by gamma-aminobutyric acid. ( Bhavsar, VH; Dhumal, VR, 1980) |
| "Gamma-Aminobutyric acid (GABA) has been implicated in the neurochemistry of epilepsy." | 3.66 | Low cerebrospinal fluid gamma-aminobutyric acid content in seizure patients. ( Ballenger, JC; Glaeser, BS; Hare, TA; Post, RM; Wood, JH, 1979) |
| " It protects mice against seizures induced by audiogenic stimuli, electroshock, thiosemicarbazide, isoniazid and strychnine." | 3.65 | Antiseizure activity of gamma-acetylenic gamma-aminobutyric acid: a catalytic irreversible inhibitor of gamma-aminobutyric acid transaminase. ( Jung, MJ; Schechter, PJ; Sjoerdsma, A; Tranier, Y, 1977) |
| "The intramuscular injection of aminooxyacetic acid (AOAA) into mice elevated the concentration of gamma-aminobutyric acid (GABA) in the brain, inhibited glutamic acid decarboxylase activity and delayed the onset of isonicotinic acid hydrazide induced seizures." | 3.65 | A dual mechanism for the anticonvulsant action of aminooxyacetic acid. ( Peesker, SJ; Wood, JD, 1976) |
| "In rabbits epileptiform seizures were induced by systemic application of methoxypyridoxine, an antimetabolite of vitamin B6." | 3.65 | Antivitamin B6 induced ultrastructural changes in the hippocampus of the convulsant rabbit and its biochemical correlates. ( Nitsch, C, 1976) |
| "Despite new antiseizure medications, the development of cholinergic-induced refractory status epilepticus (RSE) continues to be a therapeutic challenge as pharmacoresistance to benzodiazepines and other antiseizure medications quickly develops." | 3.01 | Treatment of cholinergic-induced status epilepticus with polytherapy targeting GABA and glutamate receptors. ( de Araujo Furtado, M; Lumley, L; Nguyen, D; Niquet, J, 2023) |
| "We review common toxins that cause seizure, their mechanisms, associated toxidromes, and treatments." | 2.82 | Toxin-Induced Seizures ( Phillips, HN; Tormoehlen, L, 2022) |
| "Therefore, the acute care of prolonged seizures and SE is a constant challenge for healthcare professionals, in both the pre-hospital and the in-hospital settings." | 2.82 | Benzodiazepines in the Management of Seizures and Status Epilepticus: A Review of Routes of Delivery, Pharmacokinetics, Efficacy, and Tolerability. ( Beuchat, I; Gelhard, S; Kay, L; Kienitz, R; Lucaciu, A; Mann, C; Rosenow, F; Schäfer, JH; Schubert-Bast, S; Siebenbrodt, K; Strzelczyk, A; von Brauchitsch, S; Willems, LM; Zöllner, JP, 2022) |
| "The primary goal of treatment for seizure clusters is cessation of the cluster to avoid progression to more severe conditions, such as prolonged seizures and status epilepticus." | 2.82 | Rescue therapies for seizure clusters: Pharmacology and target of treatments. ( Detyniecki, K; Gidal, B, 2022) |
| "Recent studies suggest that seizures at the onset of GBM could be a possible favorable independent prognostic factor in patients." | 2.82 | Epileptogenesis and Tumorigenesis in Glioblastoma: Which Relationship? ( Biagini, G; Cavallieri, F; Cozzi, S; Giaccherini, L; Pisanello, A; Rizzi, R; Rossi, J; Russo, M; Valzania, F, 2022) |
| "In phase II (6 weeks), patients not yet seizure-free were increased to pregabalin 600mg/day or lamotrigine 400mg/day." | 2.75 | A comparison of pregabalin, lamotrigine, and placebo as adjunctive therapy in patients with refractory partial-onset seizures. ( Barrett, J; Baulac, M; Leon, T; O'Brien, TJ; Whalen, E, 2010) |
| "Epilepsy was symptomatic in 58%, and 74% exhibited associated cognitive deficits." | 2.74 | Pregabalin: preliminary experience in intractable childhood epilepsy. ( Alsaihati, BA; Jan, MM; Zuberi, SA, 2009) |
| "Seizures were mixed in nine (47%), and four (21%) manifested Lennox-Gastaut syndrome." | 2.74 | Pregabalin: preliminary experience in intractable childhood epilepsy. ( Alsaihati, BA; Jan, MM; Zuberi, SA, 2009) |
| "Most (74%) had daily seizures that failed multiple drugs (mean, 5)." | 2.74 | Pregabalin: preliminary experience in intractable childhood epilepsy. ( Alsaihati, BA; Jan, MM; Zuberi, SA, 2009) |
| "Bodyweight gain was correlated with number of anticonvulsant drugs (r=." | 2.73 | Bodyweight gain under pregabalin therapy in epilepsy: mitigation by counseling patients? ( Elger, CE; Hoffmann, JM; Hoppe, C; Rademacher, M; Schmidt, D, 2008) |
| "Seizures were controlled in 49% of 59 children in whom gabapentin was added to other antiepilepsy drugs: 43% of the leukemia group, 53% of the brain tumor group, and 50% of the other tumor group." | 2.71 | Gabapentin to control seizures in children undergoing cancer treatment. ( Hunt, DL; Khan, RB; Thompson, SJ, 2004) |
| "At our institution, new-onset seizures in children on chemotherapy are treated with gabapentin, a nonhepatic enzyme inducer." | 2.71 | Gabapentin to control seizures in children undergoing cancer treatment. ( Hunt, DL; Khan, RB; Thompson, SJ, 2004) |
| "Gabapentin monotherapy was useful and safe for late poststroke ES." | 2.70 | Gabapentin in late-onset poststroke seizures. ( Alvarez-Sabín, J; Codina, A; Molina, CA; Montaner, J; Padró, L; Quintana, M; Rovira, R, 2002) |
| "Stroke is a frequent cause of epileptic seizures (ES) in adults." | 2.70 | Gabapentin in late-onset poststroke seizures. ( Alvarez-Sabín, J; Codina, A; Molina, CA; Montaner, J; Padró, L; Quintana, M; Rovira, R, 2002) |
| " In six patients, including three taking 6000 mg daily, GBP concentrations continued to rise linearly at each dosage increment." | 2.69 | High dose gabapentin in refractory partial epilepsy: clinical observations in 50 patients. ( Brodie, MJ; Forrest, G; Sills, GJ; Wilson, EA, 1998) |
| "Fifty patients with refractory partial seizures took part in a prospective, observational study of adjuvant gabapentin (GBP) in increasing doses." | 2.69 | High dose gabapentin in refractory partial epilepsy: clinical observations in 50 patients. ( Brodie, MJ; Forrest, G; Sills, GJ; Wilson, EA, 1998) |
| "Patients obtaining complete seizure control of all seizures or any partial seizure type during the last 8 weeks were calculated." | 2.69 | Gabapentin add-on treatment: how many patients become seizure-free? An open-label multicenter study. ( Elger, CE; Mayer, T; Schütte, W; Wolf, P, 1999) |
| "Seventy children with newly diagnosed partial epilepsy were treated with vigabatrin (38 patients) or carbamazepine (32 patients)." | 2.69 | Open comparative long-term study of vigabatrin vs carbamazepine in newly diagnosed partial seizures in children. ( Cardinali, C; Zamponi, N, 1999) |
| "The authors reviewed the occurrence of seizures in patients with epilepsy who had all their antiepileptic medications discontinued during an 8-week period, converted to gabapentin monotherapy, and observed for 26 weeks as part of the gabapentin trial #945-082." | 2.69 | Increased seizures after discontinuing carbamazepine: results from the gabapentin monotherapy trial. ( DeToledo, JC; Garofalo, EA; Greiner, M; Lowe, MR; Ramsay, RE, 2000) |
| "Gabapentin (GBP) is a non-protein-bound gamma amino acid which is not subjected to metabolic degradation in man." | 2.68 | Seizure frequency and CSF parameters in a double-blind placebo controlled trial of gabapentin in patients with intractable complex partial seizures. ( Ben-Menachem, E; Hamberger, A; Hedner, T; Persson, LI; Söderfelt, B, 1995) |
| "Vigabatrin is a novel antiepileptic drug designed to control seizures by raising brain gamma-aminobutyric acid (GABA) concentrations." | 2.68 | Human brain gamma-aminobutyric acid levels and seizure control following initiation of vigabatrin therapy. ( Behar, KL; Mattson, RH; Petroff, OA; Rothman, DL, 1996) |
| "Starting vigabatrin treatment reduced seizure frequency by > 50%, from six to seven per month to three." | 2.68 | Human brain gamma-aminobutyric acid levels and seizure control following initiation of vigabatrin therapy. ( Behar, KL; Mattson, RH; Petroff, OA; Rothman, DL, 1996) |
| " The pharmacokinetic parameters of the two enantiomers have been studied after administration of a single oral 125 mg dose of the racemate to six neonates." | 2.68 | Pharmacokinetics of the individual enantiomers of vigabatrin in neonates with uncontrolled seizures. ( Chiron, C; d'Athis, P; Dulac, O; Dumas, C; Olive, G; Pons, G; Rey, E; Vauzelle-Kervroëdan, F, 1996) |
| " During chronic administration (125 mg twice daily over 4 days), there was no evidence of accumulation of either enantiomer." | 2.68 | Pharmacokinetics of the individual enantiomers of vigabatrin in neonates with uncontrolled seizures. ( Chiron, C; d'Athis, P; Dulac, O; Dumas, C; Olive, G; Pons, G; Rey, E; Vauzelle-Kervroëdan, F, 1996) |
| "Vigabatrin (VGB) has been shown through several studies to be safe and effective as add-on therapy, particularly for the treatment of partial seizures in patients with severe epilepsies followed for years in hospital-based clinics." | 2.68 | Multicentre clinical evaluation of vigabatrin (Sabril) in mild to moderate partial epilepsies. French Neurologists Sabril Study Group. ( Arzimanoglou, AA; Dumas, C; Ghirardi, L, 1997) |
| "Simple partial seizures were reported in 121 (30." | 2.68 | Multicentre clinical evaluation of vigabatrin (Sabril) in mild to moderate partial epilepsies. French Neurologists Sabril Study Group. ( Arzimanoglou, AA; Dumas, C; Ghirardi, L, 1997) |
| "Carbamazepine dosage was decreased in five of 32 patients (16%) during the active treatment, while two patients (6%) had a dosage reduction when receiving placebo (p greater than 0." | 2.66 | Effect of progabide on serum phenytoin and carbamazepine concentrations. ( Brundage, RC; Cloyd, JC; Graves, NM; Leppik, IE; Welty, TE, 1987) |
| "Progabide (PGB) is a gamma-aminobutyric acid (GABA)-agonist drug undergoing clinical evaluation for the treatment of spasticity, movement disorders, and epilepsy." | 2.66 | Effect of progabide on serum phenytoin and carbamazepine concentrations. ( Brundage, RC; Cloyd, JC; Graves, NM; Leppik, IE; Welty, TE, 1987) |
| " In twenty-two of 32 patients (69%) receiving PGB, PHT dosage was reduced, while only four patients (12%) had their dosage reduced during placebo treatment (p less than 0." | 2.66 | Effect of progabide on serum phenytoin and carbamazepine concentrations. ( Brundage, RC; Cloyd, JC; Graves, NM; Leppik, IE; Welty, TE, 1987) |
| "Moreover, focal seizures in animal models start with increased γ-aminobutyric acid (GABA)ergic interneuronal activity that silences principal cells." | 2.53 | GABAergic networks jump-start focal seizures. ( Avoli, M; de Curtis, M, 2016) |
| "The aim of this review was to evaluate current literature for dosing recommendations for the use of antiepileptic medications in patients receiving renal replacement therapy (RRT)." | 2.53 | Antiepileptic dosing for critically ill adult patients receiving renal replacement therapy. ( Bastin, ML; Cook, AM; Oyler, DR; Smetana, KS, 2016) |
| " Micromedex® DRUGDEX as well as package inserts were used to obtain known pharmacokinetic properties and dosage adjustment recommendations in RRT if known." | 2.53 | Antiepileptic dosing for critically ill adult patients receiving renal replacement therapy. ( Bastin, ML; Cook, AM; Oyler, DR; Smetana, KS, 2016) |
| "Data regarding antiepileptic drug use in RRT are limited and mostly consist of case reports limiting our proposed dosing recommendations." | 2.53 | Antiepileptic dosing for critically ill adult patients receiving renal replacement therapy. ( Bastin, ML; Cook, AM; Oyler, DR; Smetana, KS, 2016) |
| "Additional studies are necessary before specific dosing recommendations can be made for most antiepileptic drugs in critically ill patients receiving RRT, specifically with newer agents." | 2.53 | Antiepileptic dosing for critically ill adult patients receiving renal replacement therapy. ( Bastin, ML; Cook, AM; Oyler, DR; Smetana, KS, 2016) |
| "Attempts to predict seizure timing from analyses of brain electrical activity suggest that the neurological processes involved may be initiated significantly before a seizure." | 2.49 | The paradox of the paroxysm: can seizure precipitants help explain human ictogenesis? ( Baulac, M; Huberfeld, G; Le Duigou, C; Le Van Quyen, M; Miles, R; Navarro, V, 2013) |
| "Childhood absence epilepsy and juvenile absence epilepsy are among the most common subtypes of IAEs." | 2.48 | Genes and molecular mechanisms involved in the epileptogenesis of idiopathic absence epilepsies. ( Yalçın, O, 2012) |
| "The adverse effect profile of this medication from controlled, randomized studies as well as open and long-term studies is described with consideration of the evidence-based results for pregabalin's clinical use." | 2.48 | Drug safety evaluation of pregabalin. ( Toth, C, 2012) |
| " Pregabalin use is associated with benign central nervous system and systemic adverse effects with very limited metabolic, idiosyncratic, or teratogenic adverse effects." | 2.48 | Drug safety evaluation of pregabalin. ( Toth, C, 2012) |
| "Problematic compounds may cause seizures either acutely or on withdrawal: Their use may reduce effectiveness of antiepileptic drugs, or may simply promote and enhance chaotic lifestyles." | 2.48 | Alcohol and drugs in epilepsy: pathophysiology, presentation, possibilities, and prevention. ( Borland, W; Leach, JP; Mohanraj, R, 2012) |
| "In animal experiments, seizures were found to increase NKCC1 expression, lower the KCC2 expression and accelerate neuronal differentiation." | 2.47 | Alterations in the expression of neuronal chloride transporters may contribute to schizophrenia. ( Kalkman, HO, 2011) |
| "The incidence of seizures is particularly high in the early ages of life." | 2.47 | Altered GABA signaling in early life epilepsies. ( Briggs, SW; Galanopoulou, AS, 2011) |
| "The causes of epilepsies and epileptic seizures are multifactorial." | 2.46 | Mutations affecting GABAergic signaling in seizures and epilepsy. ( Galanopoulou, AS, 2010) |
| "In particular, interictal spikes and seizures, especially if prolonged or frequent, may cause acute or long-lasting effects on brain functioning and development, which may impair performance in a variety of behavioral tests." | 2.45 | The epileptic hypothesis: developmentally related arguments based on animal models. ( Galanopoulou, AS; Moshé, SL, 2009) |
| "Studies on mechanisms of seizure generation and propagation have identified new potential targets for AEDs." | 2.45 | New antiepileptic drugs: molecular targets. ( Mula, M, 2009) |
| "Patients with partial seizures who failed > or =2 antiepileptic drugs at maximally tolerated doses." | 2.44 | Reduction of secondarily generalized tonic-clonic (SGTC) seizures with pregabalin. ( Briggs, DE; French, JA; Lee, CM; Spiegel, K, 2008) |
| "Sixteen were seizure-free during treatment and not included in the conditional analysis." | 2.44 | Reduction of secondarily generalized tonic-clonic (SGTC) seizures with pregabalin. ( Briggs, DE; French, JA; Lee, CM; Spiegel, K, 2008) |
| "Gamma-aminobutyric acid is a major inhibitory neurotransmitter in the central nervous system." | 2.44 | [Gamma-aminobutyric acid--metabolism and its disorders]. ( Kowalski, A; Rebas, E; Zylińska, L, 2007) |
| "Although seizures are very common during early brain development, consequences of seizures during this age period are less severe than in the mature brain." | 2.44 | Neurobiological mechanisms of developmental epilepsy: translating experimental findings into clinical application. ( Stafstrom, CE, 2007) |
| "Therefore, the optimal seizure management by antiepileptic drugs (AEDs) in this patient category is essentially unsure." | 2.43 | Optimal seizure management in brain tumor patients. ( van Breemen, MS; Vecht, CJ, 2005) |
| "However, specific types of seizures, such as myoclonic seizures or distinctive electroencephalographic patterns, such as suppression burst patterns, epileptic syndrome or early myoclonic encephalopathy, may suggest a specific metabolic disease." | 2.43 | [Neonatal epilepsy and inborn errors of metabolism]. ( Bahi-Buisson, N; de Lonlay, P; Desguerre, I; Dulac, O; Kaminska, A; Léger, PL; Mention, K; Nabbout, R; Plouin, P; Valayanopoulos, V, 2006) |
| "Pyridoxine-dependent seizures have been recognised for 40 years, but the clinical and biochemical features are still not understood." | 2.42 | Pyridoxine-dependent seizures: a clinical and biochemical conundrum. ( Baxter, P, 2003) |
| "Gabapentin was originally designed as an anti-convulsant gamma-aminobutyric acid (GABA) mimetic capable of crossing the blood-brain barrier." | 2.42 | Cellular and molecular action of the putative GABA-mimetic, gabapentin. ( Chung, FZ; Gonzalez, MI; Lee, K; Maneuf, YP; Pinnock, RD; Sutton, KS, 2003) |
| "Conversely, epileptic seizures have led to the anomalous sprouting of mossy fibers, a process thought to induce hyperexcitation of granule cells." | 2.41 | Functional and morphological changes in the hippocampal neuronal circuits associated with epileptic seizures. ( Ashida, H; Kanda, M; Maru, E, 2002) |
| "Although epilepsy is fundamentally a circuit phenomenon, the most basic manifestation of the hyperexcitability characteristic of epilepsy must be evident at the level of a single neuron." | 2.41 | Epilepsy-associated plasticity in gamma-aminobutyric acid receptor expression, function, and inhibitory synaptic properties. ( Coulter, DA, 2001) |
| "The events that follow epilepsy seizures are not restricted to the immediate period." | 2.41 | Cell death and synaptic reorganizations produced by seizures. ( Ben-Ari, Y, 2001) |
| "Knowledge of these syndromes has important treatment and prognostic implications, which usually extend into adulthood." | 2.41 | Adolescent seizures and epilepsy syndromes. ( Kim, HL; Wheless, JW, 2002) |
| "The characteristic clinical history, seizure semiology, and magnetic resonance imaging findings have allowed a discrete epilepsy syndrome to be established." | 2.41 | Adolescent seizures and epilepsy syndromes. ( Kim, HL; Wheless, JW, 2002) |
| "Although seizures may be a feature of the disease being treated, antibiotics should be considered possible causes of seizures, particularly if suggested by temporal relationships between seizure activity and drug administration." | 2.40 | Antibiotic-induced convulsions. ( Wallace, KL, 1997) |
| "Successful control of seizures with anticonvulsant drugs reflects a balance in achieving seizure control while minimizing undesirable drug side effects." | 2.40 | Anticonvulsant therapy in small animals. ( Boothe, DM, 1998) |
| "In rodents these seizures are readily triggered by sound (audiogenic seizures)." | 2.40 | Ethanol and neurotransmitter interactions--from molecular to integrative effects. ( Faingold, CL; N'Gouemo, P; Riaz, A, 1998) |
| "Generalized epileptic seizures are underlied by specific circuits where GABAergic synapses are involved at different levels." | 2.40 | [GABAergic mechanisms in generalized epilepsies: the neuroanatomical dimension]. ( Depaulis, A; Deransart, C; Marescaux, C; Vergnes, M, 1997) |
| "Epilepsy is a disorder of recurrent seizures that are neural in origin." | 2.40 | Seizures: classification, etiologies, and pathophysiology. ( March, PA, 1998) |
| "Partial seizures are usually due to a structural cerebrocortical lesion and may be simple or complex." | 2.40 | Seizures: classification, etiologies, and pathophysiology. ( March, PA, 1998) |
| "Successful treatment of seizure disorders in small animals requires proper patient assessment, understanding the principles of antiepileptic drug (AED) therapy, designing a strategy for pharmacotherapy, and plans for emergency treatment." | 2.40 | Antiepileptic drug therapy. ( Podell, M, 1998) |
| "While acute alterations of forebrain seizure susceptibility do not change hindbrain seizure susceptibility, chronic or repeated exposure to seizures may cause simultaneous "kindling" of both systems." | 2.38 | Role of GABA in the genesis of chemoconvulsant seizures. ( Gale, K, 1992) |
| "Definition of other pathways of seizure development and the effects of pharmacologic treatments on discrete brain regions await further research efforts." | 2.37 | Progression and generalization of seizure discharge: anatomical and neurochemical substrates. ( Gale, K, 1988) |
| "Muscimol has been used to increase our knowledge of central GABAergic systems, CNS physiology, and behavior." | 2.36 | Physiological and behavioral studies with muscimol. ( DeFeudis, FV, 1980) |
| "The inborn seizure response of Papio papio to intermittent light stimulation has been reviewed as a model of human epilepsy." | 2.36 | Photomyoclonic seizures in the baboon, Papio papio. ( Killam, EK, 1979) |
| "Valproic acid is a new antiepileptic drug." | 2.36 | Valproic acid. Review of a new antiepileptic drug. ( Bruni, J; Wilder, BJ, 1979) |
| "Childhood absence epilepsy seizures arise in the cortico-thalamocortical network due to multiple cellular and molecular mechanisms, which are still under investigation." | 1.91 | Developmental Inhibitory Changes in the Primary Somatosensory Cortex of the Stargazer Mouse Model of Absence Epilepsy. ( Grattan, DR; Hassan, M; Leitch, B, 2023) |
| "Epilepsy is a chronic neurological disorder characterized by recurrent unprovoked seizures." | 1.91 | Role of long noncoding RNAs; BDNF-AS and 17A and their relation to GABAergic dysfunction in Egyptian epileptic patients. ( Darwish, HA; Seleem, MM; Shaheen, AA; Zayed, AA, 2023) |
| "Epilepsy is highly prevalent in SSADHD, and its onset and severity correlate with an age-related decline in GABA and GABA-related metabolite levels as well as TMS markers of reduced cortical inhibition." | 1.91 | The presence and severity of epilepsy coincide with reduced γ-aminobutyrate and cortical excitatory markers in succinic semialdehyde dehydrogenase deficiency. ( Arning, E; Aygun, D; Bertoldi, M; DiBacco, ML; García-Cazorla, À; Gibson, KM; Jeltsch, K; Lee, HHC; MacMullin, P; Opladen, T; Pearl, PL; Rotenberg, A; Roullet, JB; Sachee, D; Tokatly Latzer, I; Tsuboyama, M, 2023) |
| "Neonatal seizures commonly caused by hypoxia can lead to long-term neurological outcomes." | 1.91 | Fingolimod Administration Following Hypoxia Induced Neonatal Seizure Can Restore Impaired Long-term Potentiation and Memory Performance in Adult Rats. ( Ali Mard, S; Farbood, Y; Ghafouri, S; Hajipour, S; Khombi Shooshtari, M; Moradi Chameh, H; Sarkaki, A; Sistani Karampour, N, 2023) |
| "Seizure was induced in 24 male and female pups (6 in each experimental group) at postnatal day 10 (P10) by premixed gas (5% oxygen/ 95% nitrogen) in a hypoxic chamber for 15 minutes." | 1.91 | Fingolimod Administration Following Hypoxia Induced Neonatal Seizure Can Restore Impaired Long-term Potentiation and Memory Performance in Adult Rats. ( Ali Mard, S; Farbood, Y; Ghafouri, S; Hajipour, S; Khombi Shooshtari, M; Moradi Chameh, H; Sarkaki, A; Sistani Karampour, N, 2023) |
| "In two cases isolated episodes of seizures were reported in the first few years of life, and a further affected child displayed bitemporal epileptogenic discharges on EEG without overt clinical seizures." | 1.91 | SLC4A10 mutation causes a neurological disorder associated with impaired GABAergic transmission. ( Abu-Libdeh, B; Alkuraya, FS; Almuhaizea, M; Baple, EL; Crosby, AH; Daana, M; Dweikat, I; Fasham, J; Gleeson, JG; Haack, TB; Houlden, H; Hübner, CA; Huebner, AK; Kaila, K; Khalaf-Nazzal, R; Kryeziu, N; Leslie, JS; Liebmann, L; Mancini, GMS; Maroofian, R; McGavin, L; Schlattmann, P; Shamseldin, HE; Turnpenny, PD; Ubeyratna, N; van Slegtenhorst, M; Wakeling, MN; Wilke, M; Wortmann, SB; Zaki, MS, 2023) |
| "Neonatal seizures are severe pathologies which may result in long-term neurological consequences." | 1.91 | Maternal hyperhomocysteinemia increases seizures susceptibility of neonatal rats. ( Gataulina, E; Gerasimova, E; Khalilov, I; Kurmashova, E; Sitdikova, GF; Yakovlev, AV, 2023) |
| "The higher susceptibility to seizures in rats with prenatal hHCy due to a shift in the balance of excitation/inhibition toward excitation may underlie the clinical evidence about the association of hHCy with an increased risk of epilepsy." | 1.91 | Maternal hyperhomocysteinemia increases seizures susceptibility of neonatal rats. ( Gataulina, E; Gerasimova, E; Khalilov, I; Kurmashova, E; Sitdikova, GF; Yakovlev, AV, 2023) |
| "Additionally, FMZ prevented catalepsy, significantly restored locomotor activity, reduced seizure intensity (seizure score = 0." | 1.91 | Flumazenil Pretreatment Reduces Mefenamic Acid-Induced Central Nervous System Toxicity in Mice. ( Aburass, H; Alfaqih, H; Ardianto, C; Ayoub, R; Goh, KW; Jarrar, Q; Jarrar, Y; Ming, LC; Moshawih, S, 2023) |
| "Meanwhile, it decreased the seizure severity and reduced seizure-caused anxious behavior in the PTZ-kindling mice, suggesting a significant antiepileptic activity and anxiolytic/anxiogenic potential." | 1.91 | Herb pair of Polygala tenuifolia Willd and Acorus tatarinowii Schott decoction attenuates seizures and alleviates anxiety in mice: Evidence for modulating inflammation, alleviating oxidative stress and mediating GABA pathway. ( He, X; Liu, Y; Xie, Y; Yang, Y; Yuan, X, 2023) |
| "Mean seizure class did not differ between the treatment groups." | 1.91 | E2730, an uncompetitive γ-aminobutyric acid transporter-1 inhibitor, suppresses epileptic seizures in a rat model of chronic mesial temporal lobe epilepsy. ( Ali, I; Brady, RD; Braine, E; Casillas-Espinosa, PM; Cheng, JY; Fukushima, K; Haskali, MB; Hudson, MR; Jones, NC; Jupp, B; Kwan, P; Major, B; Mychasiuk, R; O'Brien, TJ; Sachdev, P; Shultz, SR; Silva, J; Thergarajan, P; Vivash, L; Wright, DK; Yamakawa, GR, 2023) |
| "The average number of seizures per month during the previous 3 months before CNB treatment was 19." | 1.91 | Cenobamate and Clobazam Combination as Personalized Medicine in Autoimmune-Associated Epilepsy With Anti-Gad65 Antibodies. ( Aguilar-Castillo, MJ; Cabezudo-García, P; Carreño, M; Ciano-Petersen, NL; Estivill-Torrús, G; García-Martín, G; Gutierrez-Cardo, AL; López-Moreno, Y; Oliver, B; Ortega-Pinazo, J; Ramírez-García, T; Rodríguez-Uranga, JJ; Romero-Godoy, J; Sanchez-Godoy, L; Serrano-Castro, PJ, 2023) |
| "Seizures are associated with a decrease in γ-aminobutyric type A acid receptors (GABAaRs) on the neuronal surface, which may be regulated by enhanced internalization of GABAaRs." | 1.91 | Neuroplastin exerts antiepileptic effects through binding to the α1 subunit of GABA type A receptors to inhibit the internalization of the receptors. ( Huang, H; Li, S; Lu, Y; Ma, M; Sun, L; Wei, X; Wu, Y; Ye, L, 2023) |
| "An in vitro seizure model was constructed using magnesium-free extracellular fluid, and an in vivo model of status epilepticus (SE) was constructed using pentylenetetrazole (PTZ)." | 1.91 | Neuroplastin exerts antiepileptic effects through binding to the α1 subunit of GABA type A receptors to inhibit the internalization of the receptors. ( Huang, H; Li, S; Lu, Y; Ma, M; Sun, L; Wei, X; Wu, Y; Ye, L, 2023) |
| "In the in vitro seizure model, α1-containing GABAaRs showed increased internalization." | 1.91 | Neuroplastin exerts antiepileptic effects through binding to the α1 subunit of GABA type A receptors to inhibit the internalization of the receptors. ( Huang, H; Li, S; Lu, Y; Ma, M; Sun, L; Wei, X; Wu, Y; Ye, L, 2023) |
| "camara leaves on seizures induced by kainate in mice, and possible mechanisms of action." | 1.72 | An aqueous extract of Lantana camara attenuates seizures, memory impairment, and anxiety in kainate-treated mice: Evidence of GABA level, oxidative stress, immune and neuronal loss modulation. ( Kandeda, AK; Mabou, ST; Moutchida, C, 2022) |
| "However, the effect of 5-HT7 on seizures has not been exactly elucidated yet." | 1.72 | The 5-HT7 receptor antagonist SB-269970 alleviates seizure activity and downregulates hippocampal c-Fos expression in pentylenetetrazole-induced kindled rats. ( Ergul, M; Gumus, E; Ozdemir, E; Sahin, B; Taskiran, AS, 2022) |
| "Lacosamide did not increase total or neuronal apoptosis in the neocortex in vitro or in vivo." | 1.72 | Lacosamide decreases neonatal seizures without increasing apoptosis. ( Bassuk, AG; Glykys, J; Langton, RL; Sharma, S; Tiarks, GC, 2022) |
| "Lacosamide reduces neocortical seizure-like activity in neonatal mice in vitro and in vivo without an acute increase in apoptosis." | 1.72 | Lacosamide decreases neonatal seizures without increasing apoptosis. ( Bassuk, AG; Glykys, J; Langton, RL; Sharma, S; Tiarks, GC, 2022) |
| "Epilepsy is a common neurological disorder characterized by recurrent unprovoked seizures." | 1.72 | De novo Y1460C missense variant in Na ( Appendino, JP; Au, PYB; Chahine, M; Ebdalla, A; Plumereau, Q; Poulin, H; Scantlebury, MH, 2022) |
| "In the thiosemicarbazideinduced seizure model, the test compound did not reduce mortality." | 1.72 | Promising anticonvulsant N-[(2,4-dichlorophenyl) methyl]-2-(2,4-dioxo-1H-quinazolin-3-yl) acetamide: dose-dependent study and evaluation of anticonvulsant action spectrum in vivo and in silico. ( Georgiyants, V; Kayal, WE; Mishchenko, M; Severina, H; Shtrygol, D; Shtrygol, S; Zalevskyi, S, 2022) |
| "Absence seizures are hyperexcitations within the cortico-thalamocortical (CTC) network, however the underlying causative mechanisms at the cellular and molecular level are still being elucidated and appear to be multifactorial." | 1.72 | Altered GABA ( Adotevi, NK; Hassan, M; Leitch, B, 2022) |
| "Medical history interviews, seizure surveys, Vineland Adaptive Behavior Scales Second Edition and other behavioural surveys were completed by primary care givers of 28 participants in Simons Searchlight." | 1.72 | Neurodevelopmental phenotypes associated with pathogenic variants in ( Brooks, E; Chung, W; Geltzeiler, A; Green Snyder, L; Kahen, A; Kavus, H; Kentros, C; Taylor, C, 2022) |
| "Absence epilepsy is classified as a childhood generalized epilepsy syndrome with distinctive electroencephalographic patterns." | 1.62 | Vasoactive intestinal peptide (VIP) conducts the neuronal activity during absence seizures: GABA seems to be the main mediator of VIP. ( Arkan, S; Ateş, N; Korkmaz, OT; Öncü-Kaya, EM; Tunçel, N, 2021) |
| "OV329, a novel drug candidate for the treatment of epilepsy and addiction, has been shown in vitro to be substantially more potent as a GABA-AT inactivator than vigabatrin, an antiseizure drug approved as an add-on therapy for adult patients with refractory complex partial seizures and monotherapy for pediatric patients with infantile spasms." | 1.62 | OV329, a novel highly potent γ-aminobutyric acid aminotransferase inactivator, induces pronounced anticonvulsant effects in the pentylenetetrazole seizure threshold test and in amygdala-kindled rats. ( Deking, LS; During, MJ; Feja, M; Gernert, M; Kaczmarek, E; Meller, S; Silverman, RB, 2021) |
| "elegans allows our electroconvulsive seizure (ES) assay to be used as a behavioral readout of the locomotor circuit and neuronal function." | 1.62 | O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 modulate seizure susceptibility in C. elegans. ( Dawson-Scully, K; Giles, A; Grill, B; Opperman, KJ; Suthakaran, N; Wiggins, J, 2021) |
| "Epileptic seizures can be mediated by patient autoantibodies targeting ion channels expressed in the brain." | 1.62 | GABA-cadabra: autoantibodies trick neurotransmitter receptors and induce seizures. ( Masi, G; O'Connor, KC, 2021) |
| "Epileptic activity in genetic generalized epilepsy (GGE) patients preferentially appears during sleep and its mechanism remains unknown." | 1.62 | Impaired State-Dependent Potentiation of GABAergic Synaptic Currents Triggers Seizures in a Genetic Generalized Epilepsy Model. ( Catron, MA; Ding, L; Gallagher, MJ; Hanna, CM; Macdonald, RL; Zhang, CQ; Zhou, C, 2021) |
| "It is well established that seizures beget seizures, yet the cellular processes that underlie progressive epileptogenesis remain unclear." | 1.62 | Chronic loss of inhibition in piriform cortex following brief, daily optogenetic stimulation. ( Franks, KM; Lackie, M; Lee, P; Nagappan, S; Rodriguez, E; Ryu, B; Santos-Valencia, F; Takatoh, J, 2021) |
| "Here, we report that a seizure-like sustained depolarization can induce short-term inhibition of hippocampal CA3 neurons via a mechanism of membrane shunting." | 1.62 | TRESK channel contributes to depolarization-induced shunting inhibition and modulates epileptic seizures. ( Chen, R; Cong, J; Gao, TM; Guo, Y; Huang, W; Ke, Y; Kilb, W; Liu, S; Luhmann, HJ; Meng, W; Wang, K; Ye, H; Zhang, Z; Zhu, J, 2021) |
| "Absence seizures are associated with generalised synchronous 2." | 1.62 | Impact of Dysfunctional Feed-Forward Inhibition on Glutamate Decarboxylase Isoforms and γ-Aminobutyric Acid Transporters. ( Leitch, B; Lyons, NMA; Panthi, S, 2021) |
| "VGB was administered for 3 and 7 days." | 1.56 | Long-term vigabatrin treatment modifies pentylenetetrazole-induced seizures in mice: focused on GABA brain concentration. ( Czuczwar, SJ; Krzyżanowski, M; Świąder, K; Świąder, MJ; Wróbel, A; Zakrocka, I; Łuszczki, JJ, 2020) |
| "Convulsions were evoked by PTZ at its CD97 (99 mg/kg)." | 1.56 | Long-term vigabatrin treatment modifies pentylenetetrazole-induced seizures in mice: focused on GABA brain concentration. ( Czuczwar, SJ; Krzyżanowski, M; Świąder, K; Świąder, MJ; Wróbel, A; Zakrocka, I; Łuszczki, JJ, 2020) |
| "Recurrent seizures (RS) were induced by flurothyl inhalation in immature rats." | 1.56 | Recurrent seizures cause immature brain injury and changes in GABA a receptor α1 and γ2 subunits. ( Feng, J; Hu, XY; Shi, XY; Tang, JH; Wan, Y; Xi, XJ; Zhang, BB; Zhou, C, 2020) |
| "We therefore measured seizure threshold and cortical gamma-aminobutyric acid (GABA) and glutamate (Glu) concentrations, 1 and 6 weeks after rmTBI in mice." | 1.56 | Increase in Seizure Susceptibility After Repetitive Concussion Results from Oxidative Stress, Parvalbumin-Positive Interneuron Dysfunction and Biphasic Increases in Glutamate/GABA Ratio. ( Conley, GM; Damar, U; Dhamne, SC; Hameed, MQ; Hensch, TK; Hodgson, N; Hyde, D; Lee, HHC; MacMullin, P; Mannix, R; Morriss, N; Qiu, J; Rotenberg, A, 2020) |
| "Acute seizures were induced in zebrafish using pentylenetetrazol (PTZ) and cognitive function was assessed using the T-maze test of learning and memory." | 1.51 | Effect of newer anti-epileptic drugs (AEDs) on the cognitive status in pentylenetetrazol induced seizures in a zebrafish model. ( Choo, BKM; Johan Arief, MFB; Kumari, Y; Kundap, UP; Othman, I; Shaikh, MF; Wong, CP; Yap, JL, 2019) |
| "Epilepsy is marked by seizures that are a manifestation of excessive brain activity and is symptomatically treatable by anti-epileptic drugs (AEDs)." | 1.51 | Effect of newer anti-epileptic drugs (AEDs) on the cognitive status in pentylenetetrazol induced seizures in a zebrafish model. ( Choo, BKM; Johan Arief, MFB; Kumari, Y; Kundap, UP; Othman, I; Shaikh, MF; Wong, CP; Yap, JL, 2019) |
| "Anti-GABABR encephalitis is a limbic encephalitis with prominent, severe seizures, but patients can also present with rapidly progressive dementia." | 1.51 | The expanded clinical spectrum of anti-GABABR encephalitis and added value of KCTD16 autoantibodies. ( Bastiaansen, DAEM; Boukhrissi, S; de Bruijn, MAAM; de Graaff, E; Demmers, JAA; Hoogenraad, CC; Hulsenboom, ESP; Nagtzaam, MMP; Ramberger, M; Schreurs, MWJ; Sillevis Smitt, PAE; Titulaer, MJ; van Coevorden-Hameete, MH; Veldink, JH; Verschuuren, JJGM, 2019) |
| "Epilepsy is a prevalent neurological disorder that was reported to affect about 56 million people in the world." | 1.51 | The Anticonvulsant Effects of Baldrinal on Pilocarpine-Induced convulsion in Adult Male Mice. ( Guo, F; Li, X; Liu, N; Ma, L; Sun, T; Yu, J; Zhang, X; Zheng, P; Zhou, R, 2019) |
| "Spontaneous and evoked seizures were evaluated from EEG recordings, and their severity was tested by the Racine scale." | 1.51 | The Anticonvulsant Effects of Baldrinal on Pilocarpine-Induced convulsion in Adult Male Mice. ( Guo, F; Li, X; Liu, N; Ma, L; Sun, T; Yu, J; Zhang, X; Zheng, P; Zhou, R, 2019) |
| "Neonatal seizures are different from adult seizures, and many antiepileptic drugs that are effective in adults often fail to treat neonates." | 1.51 | Gluconate suppresses seizure activity in developing brains by inhibiting CLC-3 chloride channels. ( Bai, Y; Chen, G; Dong, F; Feng, M; Huo, Q; Li, ST; Long, C; Lüscher, B; Ren, L; Wang, GL; Wang, Y; Wu, G; Wu, Z, 2019) |
| "Epilepsy is a group of neurological disorders which affects millions of people worldwide." | 1.51 | Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice. ( Kaszas, A; Malliaras, GG; Proctor, CM; Slezia, A; Williamson, A, 2019) |
| "Animals were divided into sham, seizure, exercise (EX), co-seizure-induced exercise (Co-SI EX) and Pre-SI EX groups." | 1.51 | The effect of exercise on GABA signaling pathway in the model of chemically induced seizures. ( Barzroodi Pour, M; Bayat, M; Eftekharzadeh, M; Golab, F; Karimzadeh, F; Katebi, M; Soleimani, M, 2019) |
| "Seizure was induced by pentylentetrazole (PTZ) injection." | 1.51 | The effect of exercise on GABA signaling pathway in the model of chemically induced seizures. ( Barzroodi Pour, M; Bayat, M; Eftekharzadeh, M; Golab, F; Karimzadeh, F; Katebi, M; Soleimani, M, 2019) |
| "Absence seizures (ASs) are associated with abnormalities in gamma-aminobutyric acid (GABA) neurotransmission in the thalamus and the cortex." | 1.48 | Developmental changes of GABA immunoreactivity in cortico-thalamic networks of an absence seizure model. ( Bombardi, C; Crunelli, V; Di Giovanni, G; Venzi, M, 2018) |
| "A significant enhancement in the seizure threshold was observed by A." | 1.46 | Anticonvulsant activity and acute neurotoxic profile of Achyranthes aspera Linn. ( Druzhilovsky, D; Gawande, DY; Goel, RK; Gupta, RC; Poroikov, V, 2017) |
| "In six-hertz-seizure test the MeCO (25, 50, 100 and 200mg/kg) and AeCO (50, 100, 200, 400 and 800mg/kg) showed significant protection compared to control group, and MeCO was more potent than AeCO." | 1.46 | Ameliorative potential of Colebrookea oppositifolia methanolic root extract against experimental models of epilepsy: Possible role of GABA mediated mechanism. ( Prasad, NBL; Venkataranganna, MV; Viswanatha, GL, 2017) |
| "In this study, we evaluated the dose-response efficacy of levetiracetam (12." | 1.46 | Combination therapy of levetiracetam and gabapentin against nonconvulsive seizures induced by penetrating traumatic brain injury. ( Cao, Y; Liao, Z; Lu, XM; Mountney, A; Shear, DA; Tortella, FC, 2017) |
| " However, the two drugs manifested different dose-response profiles." | 1.46 | Combination therapy of levetiracetam and gabapentin against nonconvulsive seizures induced by penetrating traumatic brain injury. ( Cao, Y; Liao, Z; Lu, XM; Mountney, A; Shear, DA; Tortella, FC, 2017) |
| "Posttraumatic seizures are a medical problem affecting patients with traumatic brain injury." | 1.46 | Combination therapy of levetiracetam and gabapentin against nonconvulsive seizures induced by penetrating traumatic brain injury. ( Cao, Y; Liao, Z; Lu, XM; Mountney, A; Shear, DA; Tortella, FC, 2017) |
| "Seizures were detected by continuous electroencephalogram (EEG) monitoring for 72 hours postinjury." | 1.46 | Combination therapy of levetiracetam and gabapentin against nonconvulsive seizures induced by penetrating traumatic brain injury. ( Cao, Y; Liao, Z; Lu, XM; Mountney, A; Shear, DA; Tortella, FC, 2017) |
| "Levetiracetam attenuated seizure activity in a dose-dependent fashion, whereas the beneficial effects of gabapentin plateaued across the three highest doses tested." | 1.46 | Combination therapy of levetiracetam and gabapentin against nonconvulsive seizures induced by penetrating traumatic brain injury. ( Cao, Y; Liao, Z; Lu, XM; Mountney, A; Shear, DA; Tortella, FC, 2017) |
| "Secondary generalized seizure (sGS) is a major source of disability in temporal lobe epilepsy (TLE) with unclear cellular/circuit mechanisms." | 1.46 | Depolarized GABAergic Signaling in Subicular Microcircuits Mediates Generalized Seizure in Temporal Lobe Epilepsy. ( Chen, B; Chen, Z; Duan, S; Gao, F; Guo, Y; Ji, C; Li, X; Liang, J; Luo, J; Wang, S; Wang, Y; Wu, X; Xu, C; Xu, Z, 2017) |
| "Cortical seizure-like activity was induced by electrical stimulation of the corpus callosum after applying 4-aminopyridine." | 1.46 | Suppression of cortical seizures by optic stimulation of the reticular thalamus in PV-mhChR2-YFP BAC transgenic mice. ( Chang, WJ; Chang, WP; Shyu, BC, 2017) |
| "The diagnosis of small cell lung cancer was subsequently made after lung biopsy, and the patient showed improvement with chemotherapy and intravenous immunoglobulin." | 1.46 | Gamma-aminobutyric acid-B limbic encephalitis and asystolic cardiac arrest: a case report. ( Duggins, A; Jayamanne, A; Ovens, CA, 2017) |
| "They are classically associated with seizures and behavioral disturbance, and may coexist with other autoantibodies." | 1.46 | Gamma-aminobutyric acid-B limbic encephalitis and asystolic cardiac arrest: a case report. ( Duggins, A; Jayamanne, A; Ovens, CA, 2017) |
| "Pyridoxine-sensitive seizures characterize severe forms of infantile HPP." | 1.46 | Neuromuscular features of hypophosphatasia. ( Fonta, C; Salles, JP, 2017) |
| "Understanding the seizure-inducing mechanisms of TBI is of the utmost importance, because these seizures are often resistant to traditional first- and second-line anti-seizure treatments." | 1.46 | NKCC1 up-regulation contributes to early post-traumatic seizures and increased post-traumatic seizure susceptibility. ( Cotrina, ML; Gu, S; He, X; Huang, JH; Liu, W; Nedergaard, M; Shapiro, LA; Wang, EW; Wang, F; Wang, W; Wang, X, 2017) |
| " Results of the study indicate that 1) Early SIS could be considered as an animal model of psychosocial stress to investigate the psychiatric comorbidities in seizure disorders, 2) Chronic administration of low dose GBP prevented the shaping of behavioral abnormalities in adulthood, 3) Chronic administration of low dose GBP produced no negative behavioral effects in socially conditioned mice suggesting the safety of the drug, 4) Gabapentin at low doses may be considered as an agent for management of epilepsy in individuals with psychiatric comorbidities." | 1.46 | Protective effects of gabapentin against the seizure susceptibility and comorbid behavioral abnormalities in the early socially isolated mice. ( Amini-Khoei, H; Amiri, S; Ghazi-Khansari, M; Haj-Mirzaian, A; Mohsenzadeh, A; Olson, CO; Rahimi-Balaei, M; Rastegar, M; Razmi, A; Shirzadian, A; Zarrindast, MR, 2017) |
| "Gabapentin is an antiepileptic that is used to manage neuropathic pain." | 1.46 | Gabapentin-Induced Bullous Pemphigoid. ( Dufresne, F; Flamm, A; Sachdev, S, 2017) |
| "Bullous pemphigoid is an autoimmune blistering dermatosis with separation of the epidermis from the dermis." | 1.46 | Gabapentin-Induced Bullous Pemphigoid. ( Dufresne, F; Flamm, A; Sachdev, S, 2017) |
| "The 6-Hz-induced seizures were accompanied by reduced brain 5-HT, DA, NE, histamine, GABA, and enhanced glutamate levels." | 1.46 | Parachlorophenylalanine-induced 5-HT depletion alters behavioral and brain neurotransmitters levels in 6-Hz psychomotor seizure model in mice. ( Jahan, K; Pillai, KK; Vohora, D, 2017) |
| "Mirtazapine was more effective than desipramine in restoring somatosensory cortex thickness by fully rescuing pyramidal neurons dendritic arborization and spine density." | 1.43 | Pharmacological treatment with mirtazapine rescues cortical atrophy and respiratory deficits in MeCP2 null mice. ( Baj, G; Bernareggi, A; Bittolo, T; Deiana, C; Ferrazzo, S; Raminelli, CA; Tongiorgi, E; Vaghi, V, 2016) |
| "Cortical tubers in patients with tuberous sclerosis complex (TSC) are highly associated with intractable epilepsy." | 1.43 | Expression and cellular distribution of transient receptor potential vanilloid 4 in cortical tubers of the tuberous sclerosis complex. ( Chen, B; Chen, X; Li, S; Liang, C; Liu, S; Sun, F; Wang, L; Wei, Y; Yang, H; Yang, M; Yue, J, 2016) |
| "Vigabatrin is a clinically approved anti-seizure drug, which acts by increasing brain GABA levels by irreversibly inhibiting GABA-aminotransferase (GABA-T)." | 1.43 | Continuous bilateral infusion of vigabatrin into the subthalamic nucleus: Effects on seizure threshold and GABA metabolism in two rat models. ( Gernert, M; Gey, L; Löscher, W, 2016) |
| " The data demonstrate that chronic administration of very low, nontoxic doses of vigabatrin into STN is an effective means of increasing local GABA concentrations and seizure threshold." | 1.43 | Continuous bilateral infusion of vigabatrin into the subthalamic nucleus: Effects on seizure threshold and GABA metabolism in two rat models. ( Gernert, M; Gey, L; Löscher, W, 2016) |
| "We obtained seizures and once they had 3, 15 and 45 electric stimuli, the animals were sacrificed; the cerebellum was processed for inmunohistochemistry and Western blot analysis was performed to determine Sox-1 expression." | 1.43 | Decreased Expression of Sox-1 in Cerebellum of Rat with Generalized Seizures Induced by Kindling Model. ( Custodio, V; Eguiluz-Meléndez, A; González, E; Martínez-Lazcano, JC; Paz, C; Rosiles-Abonce, A; Rubio-Osornio, C; Rubio-Osornio, M; Trejo-Solís, C, 2016) |
| "In a seizure model caused by a mutation in the ionotropic acetylcholine receptor acr-2(gf), dnj-17(gf) exacerbates the convulsion phenotype in conjunction with absence of GABA." | 1.43 | Altered Function of the DnaJ Family Cochaperone DNJ-17 Modulates Locomotor Circuit Activity in a Caenorhabditis elegans Seizure Model. ( Jin, Y; Takayanagi-Kiya, S, 2016) |
| "The mechanism responsible for the anti-seizure effect of ketogenic diets is poorly understood." | 1.43 | Ketogenic diet prevents neuronal firing increase within the substantia nigra during pentylenetetrazole-induced seizure in rats. ( Coppola, G; Iovane, V; Monda, M; Operto, FF; Pisano, S; Stoddard, M; Viggiano, A, 2016) |
| "Zolpidem is a hypnotic medication that mainly exerts its function through activating γ-aminobutyric acid (GABA)A receptors." | 1.43 | Involvement of ATP-sensitive potassium channels and the opioid system in the anticonvulsive effect of zolpidem in mice. ( Amiri, S; Dehdashtian, A; Dehpour, AR; Ghasemi, M; Ostadhadi, S; Sheikhi, M; Shirzadian, A, 2016) |
| "His seizures were successfully controlled." | 1.42 | A novel mutation of ALDH5A1 gene associated with succinic semialdehyde dehydrogenase deficiency. ( Lee, WT; Lin, CY; Weng, WC, 2015) |
| "In addition, both types of seizures presented with higher ripple than fast ripple rates." | 1.42 | Interneuron activity leads to initiation of low-voltage fast-onset seizures. ( Avoli, M; Lévesque, M; Manseau, F; Shiri, Z; Williams, S, 2015) |
| "Behavioral convulsions were provoked by intravenous pentylenetetrazol (PTZ) application model." | 1.42 | Hippocampal orexin receptors inactivation reduces PTZ induced seizures of male rats. ( Elahdadi Salmani, M; Goudarzi, E; Goudarzi, I; Lashkarbolouki, T, 2015) |
| "SB (50 nmol) infusion reduced seizure stage, duration and decreased glutamate while GABA content was increased." | 1.42 | Hippocampal orexin receptors inactivation reduces PTZ induced seizures of male rats. ( Elahdadi Salmani, M; Goudarzi, E; Goudarzi, I; Lashkarbolouki, T, 2015) |
| "Here, we evaluated brain inflammation, synaptic protein expression, and adult hippocampal neurogenesis in the epileptogenic (1 and 2 months of age) and tonic-clonic (3." | 1.42 | Alterations in Brain Inflammation, Synaptic Proteins, and Adult Hippocampal Neurogenesis during Epileptogenesis in Mice Lacking Synapsin2. ( Ali, I; Bahonjic, E; Bakochi, A; Chugh, D; Ekdahl, CT; Etholm, L, 2015) |
| "The mechanisms underlying generalized seizures are explored with neural field theory." | 1.42 | Generalized seizures in a neural field model with bursting dynamics. ( Robinson, PA; Zhao, X, 2015) |
| "Gamma-aminobutyric acid (GABA) is a key neurotransmitter where it usually inhibits impulse transmission." | 1.42 | Gamma-aminobutyric acid loaded halloysite nanotubes and in vitro-in vivo evaluation for brain delivery. ( Çengelli Ünel, Ç; Erol, K; Kırımlıoğlu, GY; Yazan, Y, 2015) |
| "The results of seizure scoring and histopathological findings in the hippocampus revealed a more pronounced response to the same administered TMT dose in juvenile mice, compared with that in adult mice." | 1.42 | Developmental and degenerative modulation of GABAergic transmission in the mouse hippocampus. ( Im, HI; Kang, S; Kim, J; Kim, JC; Kim, SH; Lee, S; Moon, C; Park, K; Shin, T; Son, Y; Takayama, C; Yang, M, 2015) |
| "Its sedative and anti-seizure effects (1, 10, 20, and 40 mg/kg) were evaluated in male mice." | 1.42 | Involvement of the GABAergic system in the neuroprotective and sedative effects of acacetin 7-O-glucoside in rodents. ( Almazán, S; Araujo, G; Benítez-King, G; Calixto, E; Estrada-Reyes, R; Fernández-Mas, R; Gálvez, J; Orozco, S, 2015) |
| "A selective pyridoxine deficiency was seen in 94% of patients with status epilepticus (compared to 39." | 1.42 | Pyridoxine deficiency in adult patients with status epilepticus. ( Dave, HN; Eugene Ramsay, R; Irland, M; Khan, F; Sabharwal, V, 2015) |
| "When this pathway is altered, seizures develop." | 1.42 | Toxoplasma gondii Infections Alter GABAergic Synapses and Signaling in the Central Nervous System. ( Blader, IJ; Brooks, JM; Carrillo, GL; Fox, MA; Lindsay, DS; Su, J, 2015) |
| "After the epileptic seizure the decrease in DA level disappeared." | 1.40 | Alteration of striatal dopamine levels under various partial pressure of oxygen in pre-convulsive and convulsive phases in freely-moving rats. ( Lavoute, C; Risso, JJ; Rostain, JC; Weiss, M, 2014) |
| "Firstly, seizure latency was significantly prolonged by a 5-HT3 receptor agonist SR 57227 in a dose-dependent manner." | 1.40 | The anticonvulsant effects of SR 57227 on pentylenetetrazole-induced seizure in mice. ( Cui, R; Dong, X; Li, B; Liu, C; Lv, J; Shao, D; Song, Y; Sun, Z; Wang, L; Wang, P; Zhang, X; Zhao, J; Zhou, Y, 2014) |
| "Pregabalin reduced the percentage of seizures and increased the latency to seizure in the MES model in two parental mouse strains used to construct the mutants." | 1.40 | Anticonvulsant activity of pregabalin in the maximal electroshock-induced seizure assay in α2δ1 (R217A) and α2δ2 (R279A) mouse mutants. ( Donevan, S; Galvin, S; Hain, H; Lotarski, S; Offord, J; Peterson, J; Strenkowski, B, 2014) |
| "Cyclothiazide (CTZ) has been reported to simultaneously enhance glutamate receptor excitation and inhibit GABAA receptor inhibition, and in turn it evokes epileptiform activities in hippocampal neurons." | 1.40 | Downregulated GABA and BDNF-TrkB pathway in chronic cyclothiazide seizure model. ( Cheng, Z; Kong, S; Liu, J; Wang, Y, 2014) |
| "However, whether CTZ induced seizure rats could develop to have recurrent seizure still remains unknown." | 1.40 | Downregulated GABA and BDNF-TrkB pathway in chronic cyclothiazide seizure model. ( Cheng, Z; Kong, S; Liu, J; Wang, Y, 2014) |
| "Vigabatrin is an inhibitor of γ-aminobutyric acid transaminase." | 1.40 | Population pharmacokinetics analysis of vigabatrin in adults and children with epilepsy and children with infantile spasms. ( Karim, A; Kowalski, KG; Nielsen, JC; Patel, M; Tolbert, D; Wesche, DL, 2014) |
| "Vigabatrin pharmacokinetic data from six randomized controlled clinical trials and one open-label study were analyzed using nonlinear mixed-effects modeling." | 1.40 | Population pharmacokinetics analysis of vigabatrin in adults and children with epilepsy and children with infantile spasms. ( Karim, A; Kowalski, KG; Nielsen, JC; Patel, M; Tolbert, D; Wesche, DL, 2014) |
| " Covariate analysis indicated that age, creatinine clearance (CLCR), and body weight were important predictors of vigabatrin pharmacokinetic parameters." | 1.40 | Population pharmacokinetics analysis of vigabatrin in adults and children with epilepsy and children with infantile spasms. ( Karim, A; Kowalski, KG; Nielsen, JC; Patel, M; Tolbert, D; Wesche, DL, 2014) |
| "The model adequately described vigabatrin pharmacokinetic and enabled predictions of systemic exposures in pediatric patients 1-12 months of age." | 1.40 | Population pharmacokinetics analysis of vigabatrin in adults and children with epilepsy and children with infantile spasms. ( Karim, A; Kowalski, KG; Nielsen, JC; Patel, M; Tolbert, D; Wesche, DL, 2014) |
| "1 %) and relative bioavailability (F) (26." | 1.40 | Population pharmacokinetics analysis of vigabatrin in adults and children with epilepsy and children with infantile spasms. ( Karim, A; Kowalski, KG; Nielsen, JC; Patel, M; Tolbert, D; Wesche, DL, 2014) |
| "Spontaneous seizures occurred in at least 44% of animals 15-18 weeks after SE." | 1.40 | Persistent reduction of hippocampal glutamine synthetase expression after status epilepticus in immature rats. ( Bos, IW; de Graan, PN; Hessel, EV; Mulder, SD; van der Hel, WS; van Eijsden, P; Verlinde, SA, 2014) |
| "An extreme example is Dravet syndrome (DS), an infantile-onset severe epilepsy caused by heterozygous loss of function mutations in SCN1A, the gene encoding the brain type-I voltage-gated sodium channel NaV1." | 1.39 | Synergistic GABA-enhancing therapy against seizures in a mouse model of Dravet syndrome. ( Catterall, WA; Cheah, CS; Cho, AR; Oakley, JC; Scheuer, T, 2013) |
| "While seizures are usually intractable to medication in tuberous sclerosis complex (TSC), a common genetic cause of epilepsy, vigabatrin appears to have unique efficacy for epilepsy in TSC." | 1.39 | Vigabatrin inhibits seizures and mTOR pathway activation in a mouse model of tuberous sclerosis complex. ( McDaniel, SS; Rensing, NR; Wong, M; Zhang, B, 2013) |
| "Although antiseizure medication is the first-line treatment for epilepsy, currently available medications are ineffective in a significant percentage of patients and have not clearly been demonstrated to have disease-specific effects for epilepsy." | 1.39 | Vigabatrin inhibits seizures and mTOR pathway activation in a mouse model of tuberous sclerosis complex. ( McDaniel, SS; Rensing, NR; Wong, M; Zhang, B, 2013) |
| "Diabetes can exacerbate seizures and worsen seizure-related brain damage." | 1.39 | Pregabalin attenuates excitotoxicity in diabetes. ( Cheng, JT; Huang, CC; Huang, CW; Lai, MC; Tsai, JJ; Wu, SN, 2013) |
| "Diazepam-induced sleep was used for the evaluation of the sedative properties." | 1.39 | The anticonvulsant and sedative effects of Gladiolus dalenii extracts in mice. ( Moto, FC; Ngah, E; Ngo Bum, E; Ngoupaye, GT; Rakotonirina, A; Rakotonirina, SV; Taiwe, GS; Talla, E, 2013) |
| "Hypericum (H." | 1.39 | Anticonvulsant activity of Hypericum scabrum L.; possible mechanism involved. ( Ahangar, N; Ebrahimzadeh, MA; Nabavi, SF; Nabavi, SM, 2013) |
| "Understanding how seizures spread throughout the brain is an important problem in the treatment of epilepsy, especially for implantable devices that aim to avert focal seizures before they spread to, and overwhelm, the rest of the brain." | 1.39 | Mechanisms of seizure propagation in 2-dimensional centre-surround recurrent networks. ( Hall, D; Kuhlmann, L, 2013) |
| "The frequency of electrographic seizures during uptake inhibition was reduced to 35±7% (n=7) of the frequency in pre-perfusion period, and returned to 88±9% in the post-perfusion period." | 1.39 | Electrographic seizures are significantly reduced by in vivo inhibition of neuronal uptake of extracellular glutamine in rat hippocampus. ( Kanamori, K; Ross, BD, 2013) |
| "Tonic hind limb extension (seizure activity) was evoked in adult male albino Swiss mice by a current (sine-wave, 25 mA, 500 V, 50 Hz, 0." | 1.39 | Effects of WIN 55,212-2 mesylate on the anticonvulsant action of lamotrigine, oxcarbazepine, pregabalin and topiramate against maximal electroshock-induced seizures in mice. ( Czuczwar, SJ; Florek-Luszczki, M; Karwan, S; Luszczki, JJ; Wlaz, A, 2013) |
| "Gabapentin treatment was able to reduce reactive gliosis, decrease neuronal loss and normalize PSA-NCAM staining in hippocampal CA-1." | 1.39 | Gabapentin administration reduces reactive gliosis and neurodegeneration after pilocarpine-induced status epilepticus. ( Angelo, MF; Lukin, J; Ramos, AJ; Rossi, AR; Villarreal, A, 2013) |
| "Once SE was achieved, seizures were stopped with 20 mg/kg diazepam." | 1.39 | Gabapentin administration reduces reactive gliosis and neurodegeneration after pilocarpine-induced status epilepticus. ( Angelo, MF; Lukin, J; Ramos, AJ; Rossi, AR; Villarreal, A, 2013) |
| "In the brain, seizures lead to release of large amounts of polyunsaturated fatty acids including arachidonic acid (ARA)." | 1.39 | Epoxy fatty acids and inhibition of the soluble epoxide hydrolase selectively modulate GABA mediated neurotransmission to delay onset of seizures. ( Hackett, E; Hammock, BD; Hwang, SH; Inceoglu, B; Lee, KS; Morisseau, C; Rogawski, MA; Wagner, KM; Yang, J; Yoo, HJ; Zolkowska, D, 2013) |
| "Adenosine is an endogenous modulator of brain functions, which presents anticonvulsant properties." | 1.39 | Antiepileptic drugs prevent changes in adenosine deamination during acute seizure episodes in adult zebrafish. ( Bogo, MR; Bonan, CD; Nery, LR; Piato, AL; Schaefer, IC; Siebel, AM, 2013) |
| "It also antagonized strychnine induced seizures." | 1.38 | Antiepileptic activity of lobeline isolated from the leaf of Lobelia nicotianaefolia and its effect on brain GABA level in mice. ( Bodhankar, SL; Ghosh, P; Rub, RA; Tamboli, AM, 2012) |
| "Tonic hind limb extension (seizure activity) was evoked in adult male albino Swiss mice by a current (sine-wave, 25 mA, 500 V, 50 Hz, 0." | 1.38 | Interactions of pregabalin with gabapentin, levetiracetam, tiagabine and vigabatrin in the mouse maximal electroshock-induced seizure model: a type II isobolographic analysis. ( Filip, D; Florek-Luszczki, M; Luszczki, JJ, 2012) |
| "How the brain transitions into a seizure is poorly understood." | 1.38 | Transition to seizure: ictal discharge is preceded by exhausted presynaptic GABA release in the hippocampal CA3 region. ( Carlen, PL; Florez, CM; Koifman, J; Shin, DS; Valiante, TA; Ye, H; Zhang, L; Zhang, ZJ, 2012) |
| "Pretreatment with flumazenil suppressed the anticonvulsant effects of vitexin during the onset of both the seizures." | 1.38 | Neuroprotective effects of vitexin, a flavonoid, on pentylenetetrazole-induced seizure in rats. ( Abbasi, E; Nassiri-Asl, M; Shafeei, M; Sheikhi, M, 2012) |
| "The results show enhancement of seizure severity with significant reduction in GABA levels upon PTX treatment that were reversed by its combination with sodium valproate." | 1.38 | Combination of valproate and paroxetine in mice exposed to picrotoxin. ( Kamal, SM, 2012) |
| "This seizure-like swimming pattern was alleviated by the addition of either pyridoxal-5'-phosphate (PLP) or GABA and responded quickly to the anti-convulsing activity of gabapentin and phenytoin, two commonly prescribed anti-epileptic drugs (AEDs)." | 1.38 | Zebrafish larvae exposed to ginkgotoxin exhibit seizure-like behavior that is relieved by pyridoxal-5'-phosphate, GABA and anti-epileptic drugs. ( Chang, WN; Du, HC; Fu, TF; Hsiao, TH; Kao, TT; Lee, GH; Safo, MK; Sung, SY, 2012) |
| "Moreover, the seizure susceptibility increased 10 days after diphenhydramine withdrawal in wild-type mice but not in histidine decarboxylase knockout mice, which lack histamine." | 1.38 | Chronic h1-antihistamine treatment increases seizure susceptibility after withdrawal by impairing glutamine synthetase. ( Chen, Z; Fan, YY; Fang, Q; He, P; Hu, WW; Ohtsu, H; Xu, TL; Xu, ZH; Yan, HJ; Yang, Y; Zhang, CY; Zhang, XN; Zhong, K, 2012) |
| "Hypoxia-evoked seizures (H/S) early in life lead to multiple chronic neurological deficits." | 1.38 | The dynamics of changes in hippocampal GABAergic system in rats exposed to early-life hypoxia-induced seizures. ( Dudarenko, M; Himmelreich, N; Pozdnyakova, N; Yatsenko, L, 2012) |
| "A high incidence of seizures occurs during the neonatal period when immature networks are hyperexcitable and susceptible to hypersyncrhonous activity." | 1.37 | Blocking early GABA depolarization with bumetanide results in permanent alterations in cortical circuits and sensorimotor gating deficits. ( Kriegstein, AR; Wang, DD, 2011) |
| "LY293558 stopped seizures induced by soman and reduced the total duration of SE, monitored by electroencephalographic recordings within a 24 h-period after exposure." | 1.37 | The GluK1 (GluR5) Kainate/{alpha}-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist LY293558 reduces soman-induced seizures and neuropathology. ( Apland, JP; Aroniadou-Anderjaska, V; Braga, MF; Figueiredo, TH; Qashu, F; Souza, AP, 2011) |
| "Hypoxia and seizures early in life can cause multiple neurological deficits and even chronic epilepsy." | 1.37 | Perinatal hypoxia induces a long-lasting increase in unstimulated gaba release in rat brain cortex and hippocampus. The protective effect of pyruvate. ( Himmelreich, N; Parkhomenko, N; Pozdnyakova, N; Yatsenko, L, 2011) |
| "Seizures were assessed in terms of a composite seizure severity score (SSS), time of the onset of straub-like tail, onset of jerky movements of whole body, convulsions and death." | 1.37 | Amisulpride-induced seizurogenic effect: a potential role of opioid receptor-linked transduction systems. ( Chand, P; Rehni, AK; Singh, TG, 2011) |
| "Of the 135 patients, 14 (10." | 1.37 | Adjunctive pregabalin for uncontrolled partial-onset seizures: findings from a prospective audit. ( Brodie, MJ; Kelly, K; Leach, V; Parker, P; Stephen, LJ; Wilson, EA, 2011) |
| "Electroconvulsions were produced in mice by means of an alternating current (50 Hz, 500 V, 25 mA, ear-clip electrodes, 0." | 1.37 | 7-Nitroindazole, but not NG-nitro-L-arginine, enhances the anticonvulsant activity of pregabalin in the mouse maximal electroshock-induced seizure model. ( Dworzański, W; Jaskólska, A; Zółkowska, D; Łuszczki, JJ, 2011) |
| "Gabapentin is an antiepileptic drug used as adjunct therapy in the treatment of seizures." | 1.37 | Performance characteristics of the ARK diagnostics gabapentin immunoassay. ( Anderson, BL; Johnson-Davis, KL; Juenke, JM; McMillin, GA; Wienhoff, KA, 2011) |
| "In these models epileptic seizures are triggered either by external stimuli (reflex epilepsies) or by internal fluctuations." | 1.37 | Plasticity-modulated seizure dynamics for seizure termination in realistic neuronal models. ( Kalitzin, S; Koppert, MM; Lopes da Silva, FH; Viergever, MA, 2011) |
| " The results indicate that pretreatment with Parawixin 10 prevents the onset of seizures induced with kainic acid, N-methyl-D-aspartate, and pentylenetetrazole in a dose-response manner." | 1.37 | Neurobiological activity of Parawixin 10, a novel anticonvulsant compound isolated from Parawixia bistriata spider venom (Araneidae: Araneae). ( Beleboni, RO; Coutinho-Netto, J; Cunha, AO; dos Santos, WF; Fachim, HA; Gobbo-Neto, L; Lopes, NP; Pereira, AC, 2011) |
| "The pSC has proconvulsant audiogenic seizure activity in Wistar audiogenic rats." | 1.37 | Behavioral and EEG effects of GABAergic manipulation of the nigrotectal pathway in the Wistar audiogenic rat strain. ( de Oliveira, JA; Garcia-Cairasco, N; Rodrigues, MC; Rossetti, F, 2011) |
| "Numerous seizure prediction algorithms predicated on identifying changes prior to seizure onset have met with little success, underscoring our lack of understanding of the dynamics of transition to seizure, amongst other inherent limitation." | 1.37 | Transition to seizure: from "macro"- to "micro"-mysteries. ( Carlen, PL; Valiante, TA; Zhang, ZJ, 2011) |
| "Because our seizure model is very severe, it is probable that this technique would have a robust effect in human focal epilepsy." | 1.36 | Optical suppression of experimental seizures in rat brain slices. ( Rode, DL; Rothman, SM; Schmidt, BF; Yang, XF, 2010) |
| "To evaluate the effects of high-frequency electrical stimulation (HFS) in both ventral hippocampi, alone and combined with a subeffective dose of antiepileptic drugs, during the status epilepticus (SE) induced by lithium-pilocarpine (LP)." | 1.36 | Antiepileptic drugs combined with high-frequency electrical stimulation in the ventral hippocampus modify pilocarpine-induced status epilepticus in rats. ( Alcantara-Gonzalez, D; Cuellar-Herrera, M; Neri-Bazan, L; Peña, F; Rocha, L, 2010) |
| " One minute following pilocarpine injection, HFS (pulses of 60 mus width at 130 Hz at subthreshold intensities and applied during 3 h) was applied alone or combined with subeffective doses of antiepileptic drugs." | 1.36 | Antiepileptic drugs combined with high-frequency electrical stimulation in the ventral hippocampus modify pilocarpine-induced status epilepticus in rats. ( Alcantara-Gonzalez, D; Cuellar-Herrera, M; Neri-Bazan, L; Peña, F; Rocha, L, 2010) |
| " This effect was not evident when HFS was combined with phenytoin (33." | 1.36 | Antiepileptic drugs combined with high-frequency electrical stimulation in the ventral hippocampus modify pilocarpine-induced status epilepticus in rats. ( Alcantara-Gonzalez, D; Cuellar-Herrera, M; Neri-Bazan, L; Peña, F; Rocha, L, 2010) |
| "We show that kcc(DHS1) seizure sensitivity in MB neurons acts via a weakening of chemical synaptic inhibition by GABAergic transmission and suggest that this is due to disruption of intracellular Cl(-) gradients in MB neurons." | 1.36 | Seizure sensitivity is ameliorated by targeted expression of K+-Cl- cotransporter function in the mushroom body of the Drosophila brain. ( Fajilan, AA; Hekmat-Scafe, DS; Hsu, R; Lee, AW; Mercado, A; Mount, DB; Tanouye, MA, 2010) |
| "Scopoletin which was identified as the major constituent of the extract was found to be an inhibitor of GABA-T (IC50=10." | 1.36 | Anticonvulsant activity of Benkara malabarica (Linn.) root extract: In vitro and in vivo investigation. ( Ahmad, S; Akhtar, M; Basu, A; Basu, M; Dev, A; Jayaprakash, V; Mishra, N; Oraon, A; Pattnaik, AK; Swaroop, S; Tripapthi, SN, 2010) |
| "The aim of this study was to characterize the anticonvulsant effects of 1-methyl-1,2,3,4-tetrahydroisoquinoline (MeTHIQ--an endogenous parkinsonism-preventing substance) in combination with four second-generation antiepileptic drugs (AEDs: lamotrigine [LTG], oxcarbazepine [OXC], pregabalin [PGB], and topiramate [TPM]) in the mouse maximal electroshock (MES)-induced seizure model by using the type I isobolographic analysis for parallel and non-parallel dose-response relationship curves (DRRCs)." | 1.36 | Interactions of 1-methyl-1,2,3,4-tetrahydroisoquinoline with lamotrigine, oxcarbazepine, pregabalin, and topiramate in the mouse maximal electroshock-induced seizure model: a type I isobolographic analysis. ( Antkiewicz-Michaluk, L; Czuczwar, SJ; Luszczki, JJ; Raszewski, G, 2010) |
| "SRA880 did not affect seizure severity and did not reverse the anticonvulsive action of SRIF-14 (1 microM) against pilocarpine-induced seizures, suggesting that hippocampal sst(1) receptors are not involved in the anticonvulsive effects of SRIF-14." | 1.36 | Hippocampal sst(1) receptors are autoreceptors and do not affect seizures in rats. ( Aourz, N; Clinckers, R; De Bundel, D; Hoyer, D; Kastellakis, A; Kiagiadaki, F; Michotte, Y; Smolders, I; Thermos, K, 2010) |
| "PTZ provoked clonic convulsions, reduced GABA content, deranged brain redox status, and elevated nitric oxide (NO)." | 1.36 | Magnesium supplementation enhances the anticonvulsant potential of valproate in pentylenetetrazol-treated rats. ( Abdallah, DM; Abdel-Aziz, MT; Arafa, NM; Safar, MM, 2010) |
| "To characterize the anticonvulsant effects of pregabalin (PGB - a third-generation antiepileptic drug) in combination with carbamazepine (CBZ - a classical antiepileptic drug) in the mouse maximal electroshock (MES)-induced seizure model by using the type I isobolographic analysis for non-parallel dose-response relationship curves (DRRCs)." | 1.36 | Interaction of pregabalin with carbamazepine in the mouse maximal electroshock-induced seizure model: a type I isobolographic analysis for non-parallel dose-response relationship curves. ( Luszczki, JJ, 2010) |
| "Tonic hind limb extension (seizure activity) was evoked in adult male albino Swiss mice by a current (sine-wave, 25mA, 500V, 50Hz, 0." | 1.36 | Interaction of pregabalin with carbamazepine in the mouse maximal electroshock-induced seizure model: a type I isobolographic analysis for non-parallel dose-response relationship curves. ( Luszczki, JJ, 2010) |
| "Our findings demonstrated that seizures induced by (PhSe)₂ are mediated, at least in part, by an interaction with GABAergic system." | 1.36 | Diphenyl diselenide-induced seizures in rat pups: possible interaction with GABAergic system. ( Nogueira, CW; Prigol, M; Wilhelm, EA; Zeni, G, 2010) |
| "FGF22-deficient mice are resistant to epileptic seizures, and FGF7-deficient mice are prone to them, as expected from the alterations in excitatory/inhibitory balance." | 1.36 | Distinct FGFs promote differentiation of excitatory and inhibitory synapses. ( Javed, D; Johnson-Venkatesh, EM; Sutton, MA; Terauchi, A; Toth, AB; Umemori, H, 2010) |
| "Testosterone modulates seizure susceptibility, but the underlying mechanisms are obscure." | 1.36 | The testosterone-derived neurosteroid androstanediol is a positive allosteric modulator of GABAA receptors. ( Jian, K; Reddy, DS, 2010) |
| ", lamotrigine [LTG], oxcarbazepine [OXC] and topiramate [TPM]) in the mouse maximal electroshock (MES)-induced seizure model by using the type I isobolographic analysis for non-parallel dose-response relationship curves (DRRCs)." | 1.36 | Additive interactions of pregabalin with lamotrigine, oxcarbazepine and topiramate in the mouse maximal electroshock-induced seizure model: a type I isobolographic analysis for non-parallel dose-response relationship curves. ( Czuczwar, SJ; Filip, D; Luszczki, JJ, 2010) |
| "Tonic hind limb extension (seizure activity) was evoked in adult male albino Swiss mice by a current (sine-wave, 25mA, 500V, 50Hz, 0." | 1.36 | Additive interactions of pregabalin with lamotrigine, oxcarbazepine and topiramate in the mouse maximal electroshock-induced seizure model: a type I isobolographic analysis for non-parallel dose-response relationship curves. ( Czuczwar, SJ; Filip, D; Luszczki, JJ, 2010) |
| "For taurine treatment, mice were either fed taurine in drinking water (0." | 1.36 | Pharmacological characterization of GABAA receptors in taurine-fed mice. ( El Idrissi, A; L'Amoreaux, WJ; Marsillo, A, 2010) |
| " Additionally we reported that GABAA receptors were down regulated with chronic administration of taurine." | 1.36 | Pharmacological characterization of GABAA receptors in taurine-fed mice. ( El Idrissi, A; L'Amoreaux, WJ; Marsillo, A, 2010) |
| " Injection of taurine 15 min before picrotoxin significantly delayed seizure onset, as did chronic administration of taurine in the diet." | 1.36 | Pharmacological characterization of GABAA receptors in taurine-fed mice. ( El Idrissi, A; L'Amoreaux, WJ; Marsillo, A, 2010) |
| "Conclusions from studies comparing seizure characteristics between WT and Cx36 KO mice must be viewed with a degree of caution because of the possible confounding effect of compensatory neurophysiological changes in the genetically modified animals." | 1.36 | GABAergic compensation in connexin36 knock-out mice evident during low-magnesium seizure-like event activity. ( Jacobson, G; Melin, S; Sleigh, JW; Voss, LJ, 2010) |
| "After the seizures had been established, cells were transplanted into the substantia nigra." | 1.35 | Intranigral transplants of a GABAergic cell line produce long-term alleviation of established motor seizures. ( Aguilar, MB; Castillo, CG; Freed, WJ; Giordano, M; Mendoza-Trejo, S, 2008) |
| "In NPN2 deficient mice, we measured seizure susceptibility after kainic acid or pentylenetetrazol, neuronal excitability and synaptic throughput in slice preparations, principal and interneuron cell counts with immunocytochemical protocols, synaptosomal protein levels with immunoblots, and dendritic morphology with Golgi-staining." | 1.35 | Decreased number of interneurons and increased seizures in neuropilin 2 deficient mice: implications for autism and epilepsy. ( Bachstetter, A; Barnes, GN; Blalock, EM; Gant, JC; Hauser, KF; Kotick, J; Li, Y; Mervis, R; Schauwecker, PE; Smith, GM; Thibault, O; Yang, J, 2009) |
| "NPN2 deficient mice had shorter seizure latencies, increased vulnerability to seizure-related death, were more likely to develop spontaneous recurrent seizure activity after chemical challenge, and had an increased slope on input/output curves." | 1.35 | Decreased number of interneurons and increased seizures in neuropilin 2 deficient mice: implications for autism and epilepsy. ( Bachstetter, A; Barnes, GN; Blalock, EM; Gant, JC; Hauser, KF; Kotick, J; Li, Y; Mervis, R; Schauwecker, PE; Smith, GM; Thibault, O; Yang, J, 2009) |
| "Seizures were assessed in terms of the time latency of the onset of Straub's tail phenomenon, onset of jerky movements of whole body, convulsions and death." | 1.35 | Tramadol-induced seizurogenic effect: a possible role of opioid-dependent gamma-aminobutyric acid inhibitory pathway. ( Kumar, M; Rehni, AK; Singh, I, 2008) |
| "In the maximal electroshock seizure threshold test, electroconvulsions were produced by a current with various intensities whilst in the pentylenetetrazole test a CD(97) dose (100 mg/kg) was used." | 1.35 | Isobolographic and behavioral characterizations of interactions between vigabatrin and gabapentin in two experimental models of epilepsy. ( Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N, 2008) |
| "Calpains are a family of calcium-dependent proteases with abundant expression in the CNS, and potent in cleaving some synaptic components." | 1.35 | Calpain activity contributes to the control of SNAP-25 levels in neurons. ( Antonucci, F; Berghuis, P; Bonanno, G; Caleo, M; Carmignoto, G; Dobszay, MB; Grumelli, C; Harkany, T; Matteoli, M; Pozzi, D; Verderio, C, 2008) |
| " Daily median dosage was 300 mg." | 1.35 | Pregabalin in patients with primary brain tumors and seizures: a preliminary observation. ( Novy, J; Rossetti, AO; Stupp, R, 2009) |
| "Patients with brain tumors and seizures should be treated with non-enzyme-inducing antiepileptic drugs (AED)." | 1.35 | Pregabalin in patients with primary brain tumors and seizures: a preliminary observation. ( Novy, J; Rossetti, AO; Stupp, R, 2009) |
| "All subjects experienced at least a 50% seizure reduction, six were seizure-free." | 1.35 | Pregabalin in patients with primary brain tumors and seizures: a preliminary observation. ( Novy, J; Rossetti, AO; Stupp, R, 2009) |
| "Furthermore, the threshold of seizures induced by pentylenetetrazol was significantly reduced in both heterozygous and null mutants." | 1.35 | Efhc1 deficiency causes spontaneous myoclonus and increased seizure susceptibility. ( Delgado-Escueta, AV; Hensch, TK; Hirota, Y; Inoue, I; Itohara, S; Jiang, B; Miyamoto, H; Nakahari, T; Saido, TC; Sawamoto, K; Suemoto, T; Suzuki, T; Tsumoto, T; Yamakawa, K, 2009) |
| " In contrast, levetiracetam was without affect on tiagabine or vigabatrin concentrations and co-administration with gabapentin, tiagabine or vigabatrin had no effect on levetiracetam brain concentrations, indicating the pharmacodynamic nature of interaction between these antiepileptic drugs in the mouse pentylenetetrazole model." | 1.35 | Pharmacodynamic and pharmacokinetic interaction profiles of levetiracetam in combination with gabapentin, tiagabine and vigabatrin in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis. ( Andres-Mach, MM; Czuczwar, SJ; Dudra-Jastrzebska, M; Luszczki, JJ; Patsalos, PN; Ratnaraj, N; Sielski, M, 2009) |
| " Measurement of total brain antiepileptic drug concentrations revealed that levetiracetam in combination with gabapentin at the fixed-ratio of 1:4 significantly elevated (21%) total brain gabapentin concentrations." | 1.35 | Pharmacodynamic and pharmacokinetic interaction profiles of levetiracetam in combination with gabapentin, tiagabine and vigabatrin in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis. ( Andres-Mach, MM; Czuczwar, SJ; Dudra-Jastrzebska, M; Luszczki, JJ; Patsalos, PN; Ratnaraj, N; Sielski, M, 2009) |
| "Clonic seizures were evoked in Albino Swiss mice by subcutaneous injection of pentylenetetrazole at its CD(97)(98 mg/kg)." | 1.35 | Pharmacodynamic and pharmacokinetic interaction profiles of levetiracetam in combination with gabapentin, tiagabine and vigabatrin in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis. ( Andres-Mach, MM; Czuczwar, SJ; Dudra-Jastrzebska, M; Luszczki, JJ; Patsalos, PN; Ratnaraj, N; Sielski, M, 2009) |
| "Flumazenil pretreatment decreased the prolongation of seizure latency induced by both diazepam and isopulegol, although it was not able to reverse the latency and protection percent for mortality." | 1.35 | Effects of isopulegol on pentylenetetrazol-induced convulsions in mice: possible involvement of GABAergic system and antioxidant activity. ( de Aquino Neto, MR; de Lavor, EP; de Sousa, DP; de Sousa, FC; de Sousa, HL; de Vasconcelos, PF; Macêdo, DS; Moura, BA; Silva, MA; Silva, MI; Vasconcelos, SM, 2009) |
| "The latency for development of convulsions and mortality, as well as the mortality protection percentage was recorded." | 1.35 | Effects of isopulegol on pentylenetetrazol-induced convulsions in mice: possible involvement of GABAergic system and antioxidant activity. ( de Aquino Neto, MR; de Lavor, EP; de Sousa, DP; de Sousa, FC; de Sousa, HL; de Vasconcelos, PF; Macêdo, DS; Moura, BA; Silva, MA; Silva, MI; Vasconcelos, SM, 2009) |
| "Electroclinical uncoupling of neonatal seizures refers to electrographic seizure activity that is not clinically manifest." | 1.35 | Differences in cortical versus subcortical GABAergic signaling: a candidate mechanism of electroclinical uncoupling of neonatal seizures. ( Augustine, G; Bacskai, BJ; Dzhala, VI; Feng, G; Glykys, J; Kuchibhotla, KV; Kuner, T; Staley, KJ, 2009) |
| " In the present retrospective study we evaluated the impact of these vendor changes on ketamine dosing to establish anaesthesia, on pilocarpine-induced seizure susceptibility, and on basal extracellular hippocampal noradrenaline, dopamine, serotonin, gamma-amino butyric acid, and glutamate levels of all pilocarpine-treated rats included in our studies." | 1.35 | Intrastrain differences in seizure susceptibility, pharmacological response and basal neurochemistry of Wistar rats. ( Aourz, N; Clinckers, R; De Bundel, D; Meurs, A; Michotte, Y; Portelli, J; Smolders, I, 2009) |
| "Seizures were evoked in freely moving rats by intrahippocampal microperfusion, via a microdialysis probe, of the muscarinic receptor agonist pilocarpine (10mM), GABA(A) receptor antagonist picrotoxin (100microM) or group I metabotropic glutamate receptor agonist (R,S)-3,5-dihydroxyphenylglycine (DHPG) (1mM)." | 1.35 | Seizure activity and changes in hippocampal extracellular glutamate, GABA, dopamine and serotonin. ( Clinckers, R; Ebinger, G; Meurs, A; Michotte, Y; Smolders, I, 2008) |
| "During seizures, hippocampal glutamate, GABA and dopamine concentrations increased in all groups." | 1.35 | Seizure activity and changes in hippocampal extracellular glutamate, GABA, dopamine and serotonin. ( Clinckers, R; Ebinger, G; Meurs, A; Michotte, Y; Smolders, I, 2008) |
| "Acute seizure activity was behaviorally scored and hemispheric brain atrophy measured." | 1.35 | Gabapentin neuroprotection and seizure suppression in immature mouse brain ischemia. ( Comi, AM; Johnston, MV; Kadam, SD; Mulholland, JD; Traa, BS, 2008) |
| "The neonatal period is critical for seizure susceptibility, and neocortical networks are central in infantile epilepsies." | 1.35 | Layer-specific generation and propagation of seizures in slices of developing neocortex: role of excitatory GABAergic synapses. ( Ben-Ari, Y; Represa, A; Rheims, S; Zilberter, Y, 2008) |
| " When dosed at 10mg/kg, beta-acids increased, in the elevated plus maze, open arm entries reducing in parallel those in closed arms." | 1.34 | Evidence that the beta-acids fraction of hops reduces central GABAergic neurotransmission. ( Avallone, R; Baraldi, M; Brusiani, F; Losi, G; Puia, G; Rivasi, M; Zanoli, P; Zavatti, M, 2007) |
| "Postictal seizure protection (PSP) is an endogenous anticonvulsant phenomenon that follows an epileptic seizure and inhibits the induction of further seizures." | 1.34 | Lesion of the tuberomammillary nucleus E2-region attenuates postictal seizure protection in rats. ( Chen, Z; Jin, CL; Luo, JH; Wang, S; Wu, DC; Zhu, YY; Zhuge, ZB, 2007) |
| "We show here that, after seizures, the dentate gyrus (DG) tonically inhibits beta/gamma (20-24 Hz) field oscillations in the CA3 area through GABA-mediated signaling." | 1.34 | Beta/gamma oscillatory activity in the CA3 hippocampal area is depressed by aberrant GABAergic transmission from the dentate gyrus after seizures. ( Gutiérrez, R; Treviño, M; Vivar, C, 2007) |
| "Latrunculin A (4 microg/ml) was perfused for three consecutive days (8h a day) to promote in vivo F-actin depolymerization." | 1.34 | Changes in extracellular amino acid concentrations in the rat hippocampus after in vivo actin depolymerization with latrunculin A. ( Oreiro-García, MT; Sierra-Marcuño, G; Sierra-Paredes, G; Vázquez-Illanes, MD, 2007) |
| " The anticonvulsant and acute adverse effects of the combination of TPM with GBP at the fixed ratio of 1:1 were determined using the type I isobolographic analysis for nonparallel dose-response relationship curves (DRRCs)." | 1.34 | Isobolographic analysis of interaction between drugs with nonparallel dose-response relationship curves: a practical application. ( Luszczki, JJ, 2007) |
| "After 5 days of GBP infusion, seizures were induced by flurothyl dripped onto filter paper." | 1.34 | Intraventricular administration of gabapentin in the rat increases flurothyl seizure threshold. ( Fisher, RS; Kraus, AC; Oommen, J, 2007) |
| "First tonic-clonic seizure was at 295." | 1.34 | Intraventricular administration of gabapentin in the rat increases flurothyl seizure threshold. ( Fisher, RS; Kraus, AC; Oommen, J, 2007) |
| "Time to first myoclonic or partial seizure was not influenced." | 1.34 | Intraventricular administration of gabapentin in the rat increases flurothyl seizure threshold. ( Fisher, RS; Kraus, AC; Oommen, J, 2007) |
| "While seizures may affect adversely maternal and fetal outcome, antiepileptic drugs (AEDs) may increase the incidence of congenital abnormalities and possibly affect postnatal cognitive development in the offspring." | 1.34 | Fetal exposure to GABA-acting antiepileptic drugs generates hippocampal and cortical dysplasias. ( Ben-Ari, Y; Depaulis, A; Jorquera, I; Manent, JB; Mazzucchelli, I; Perucca, E; Represa, A, 2007) |
| "Chronic transauricular kindled seizure was induced by repeated application of initially subconvulsive electrical stimulation (40 mA, 0." | 1.34 | [Effects of acute maximal electroshock and chronic transauricular kindled seizures on learning abilities in Sprague-Dawley rats]. ( Chen, Z; Li, Q; Wu, DC; Zhang, Q, 2007) |
| "Chronic transauricular kindled seizures induced CA1 neuron damage and a decrease in histamine levels in the hippocampus." | 1.34 | [Effects of acute maximal electroshock and chronic transauricular kindled seizures on learning abilities in Sprague-Dawley rats]. ( Chen, Z; Li, Q; Wu, DC; Zhang, Q, 2007) |
| "Different types of kindling seizure produce different effects on cognitive behavior: (1) an acute MES impairs learning ability, which may be associated with an abnormal plasticity and an increase of GABA in the hippocampus; (2) the chronic transauricular kindled seizure impairs retrieval memory mainly, which may be related to CA1 neuron damage and a decrease in histaminergic activity in the hippocampus." | 1.34 | [Effects of acute maximal electroshock and chronic transauricular kindled seizures on learning abilities in Sprague-Dawley rats]. ( Chen, Z; Li, Q; Wu, DC; Zhang, Q, 2007) |
| "The patient presented with seizures and a reduced level of consciousness." | 1.34 | Self-poisoning with lamotrigine and pregabalin. ( Braga, AJ; Chidley, K, 2007) |
| "The therapy of focal epilepsy remains unsatisfactory for as many as 25% of patients." | 1.34 | Optical suppression of seizure-like activity with an LED. ( Hyrc, K; Perry, G; Rothman, SM; Schmidt, BF; Yang, XF, 2007) |
| "Methylmalonic acid (MMA) is an endogenous convulsing compound that accumulates in methylmalonic acidemia, an inborn error of the metabolism characterized by severe neurological dysfunction, including seizures." | 1.34 | Convulsions induced by methylmalonic acid are associated with glutamic acid decarboxylase inhibition in rats: a role for GABA in the seizures presented by methylmalonic acidemic patients? ( Fighera, MR; Garrido-Sanabria, ER; Malfatti, CR; Mello, CF; Muller, AP; Paquetti, L; Perry, ML; Rigo, FK; Schweigert, ID, 2007) |
| "The mechanisms by which MMA causes seizures involves the activation of the N-methyl-D-aspartate (NMDA) receptors, but whether GABAergic mechanisms are involved in the convulsions induced by MMA is not known." | 1.34 | Convulsions induced by methylmalonic acid are associated with glutamic acid decarboxylase inhibition in rats: a role for GABA in the seizures presented by methylmalonic acidemic patients? ( Fighera, MR; Garrido-Sanabria, ER; Malfatti, CR; Mello, CF; Muller, AP; Paquetti, L; Perry, ML; Rigo, FK; Schweigert, ID, 2007) |
| "Convulsions were confirmed by electroencephalographic recording in a subset of animals." | 1.34 | Convulsions induced by methylmalonic acid are associated with glutamic acid decarboxylase inhibition in rats: a role for GABA in the seizures presented by methylmalonic acidemic patients? ( Fighera, MR; Garrido-Sanabria, ER; Malfatti, CR; Mello, CF; Muller, AP; Paquetti, L; Perry, ML; Rigo, FK; Schweigert, ID, 2007) |
| "While the rat was behaving freely, a seizure-inducing concentration of acetylcholine (Ach) was applied into the cup." | 1.34 | Transmeningeal delivery of GABA to control neocortical seizures in rats. ( Baptiste, SL; Devinsky, O; John, JE; Kuzniecky, RI; Ludvig, N; Sheffield, LG; von Gizycki, H, 2007) |
| "Imperatorin at lower doses of 20 and 30 mg/kg had no significant effect on the anticonvulsant activities of conventional antiepileptic drugs in the mouse maximal electroshock seizure model." | 1.34 | Imperatorin enhances the protective activity of conventional antiepileptic drugs against maximal electroshock-induced seizures in mice. ( Czuczwar, SJ; Glowniak, K; Luszczki, JJ, 2007) |
| "Status epilepticus was evoked in mice by intra-amygdala kainic acid, causing cytochrome c release, processing of caspases 9 and 7, and death of ipsilateral hippocampal pyramidal neurons." | 1.34 | Bcl-w protects hippocampus during experimental status epilepticus. ( Bellver-Estelles, C; Chu, X; Dicker, P; Dunleavy, M; Hatazaki, S; Henshall, D; Koegel, I; Meller, R; Murphy, B; Prehn, J; Schindler, C; Shinoda, S; Simon, R; Wang, W; Xiong, Z; Yamamoto, A, 2007) |
| "Experimentally evoked seizures can activate the intrinsic mitochondrial cell death pathway, components of which are modulated in the hippocampus of patients with temporal lobe epilepsy." | 1.34 | Bcl-w protects hippocampus during experimental status epilepticus. ( Bellver-Estelles, C; Chu, X; Dicker, P; Dunleavy, M; Hatazaki, S; Henshall, D; Koegel, I; Meller, R; Murphy, B; Prehn, J; Schindler, C; Shinoda, S; Simon, R; Wang, W; Xiong, Z; Yamamoto, A, 2007) |
| " Additionally, the effects of acute and chronic administration of aminophylline on the adverse effect potential of gabapentin in terms of motor coordination impairment were assessed in the chimney test." | 1.34 | Influence of aminophylline on the anticonvulsive action of gabapentin in the mouse maximal electroshock seizure threshold model. ( Czuczwar, SJ; Jankiewicz, K; Jankiewicz, M; Luszczki, JJ, 2007) |
| "Infantile Neuronal Ceroid Lipofuscinosis (INCL) results from mutations in the palmitoyl protein thioesterase (PPT1, CLN1) gene and is characterized by dramatic death of cortical neurons." | 1.33 | Mice with Ppt1Deltaex4 mutation replicate the INCL phenotype and show an inflammation-associated loss of interneurons. ( Fabritius, AL; Gentile, M; Jalanko, A; Kopra, O; Manninen, T; Minye, H; Peltonen, L; Rapola, J; Salonen, T; Vesa, J; von Schantz, C, 2005) |
| " The effect of SNP was tested alone and in combination with phenobarbitone (PB), the GABA potentiating antiepileptic drug, against picrotoxin (PCT) (5 mg/kg)-induced convulsions in rats." | 1.33 | Effects of sodium nitroprusside, a nitric oxide donor, on gamma-aminobutyric acid concentration in the brain and on picrotoxin-induced convulsions in combination with phenobarbitone in rats. ( Ekambaram, P; Paul, V, 2005) |
| "A model of hypoxia-induced seizures in immature rats reveals that seizures result in immediate activation of the phosphatase calcineurin (CaN) in area CA1 of hippocampus." | 1.33 | AMPA/kainate receptor-mediated downregulation of GABAergic synaptic transmission by calcineurin after seizures in the developing rat brain. ( Dai, W; Jensen, FE; Levada, RE; Lippman, JJ; Sanchez, RM, 2005) |
| " These results present a novel interpretation of synergistic inhibition of certain epileptic discharges using vigabatrin and another drug, and that for successful synergistic treatment of epilepsies carefully designed timed dosage regimens are essential." | 1.33 | Antiepileptic action induced by a combination of vigabatrin and tiagabine. ( Fueta, Y; Kunugita, N; Schwarz, W, 2005) |
| "Both extracts can prevent convulsions as well as convulsion-related GABAergic neuron damage in the brain in the prolonged PTZ kindling model." | 1.33 | Study of antiepileptic effect of extracts from Acorus tatarinowii Schott. ( Chen, L; Gao, MM; Liao, WP; Su, T; Sun, WW; Yang, SQ; Yi, YH, 2005) |
| "Progestins can have antiseizure effects; however, the mechanisms and sites of action of these effects are not well-understood." | 1.33 | Actions at GABA(A) receptors in the hippocampus may mediate some antiseizure effects of progestins. ( Frye, CA; Rhodes, ME, 2005) |
| "Intractable seizures originating in the mesial temporal lobe can often be controlled by resection." | 1.33 | Genetically engineered cells with regulatable GABA production can affect afterdischarges and behavioral seizures after transplantation into the dentate gyrus. ( Thompson, KW, 2005) |
| "We determined the onset and duration of convulsions induced by bicuculline alone or by co-exposure to MFs and bicuculline." | 1.33 | Extremely low frequency magnetic fields modulate bicuculline-induced-convulsion in rats. ( Choi, HJ; Choi, KB; Im, BO; Jeong, JH; Ko, SK; Min, YS; Sohn, UD; Song, HJ, 2005) |
| "Mefloquine dose dependently induced tonic seizures in mice." | 1.33 | Gamma-aminobutyric acid and mefloquine-induced seizures in mice. ( Amabeoku, GJ; Farmer, CC, 2005) |
| "The heightened susceptibility to seizures appears to be due, at least in part, to developmental changes that skew the balance between excitatory and inhibitory neurotransmitter systems in the brain in favor of a state of excitation." | 1.33 | Rearranging receptors. ( Brooks-Kayal, AR, 2005) |
| "Patients were stabilised using phenobarbitone and/or potassium bromide to produce tolerable therapeutic serum concentrations and dosed additionally with gabapentin at 35 to 50 mg/kg/d (divided twice or three times daily) for 4 months." | 1.33 | Improving seizure control in dogs with refractory epilepsy using gabapentin as an adjunctive agent. ( Govendir, M; Malik, R; Perkins, M, 2005) |
| "To assess whether there is a change in seizure activity in dogs with refractory epilepsy that are receiving appropriate doses of phenobarbitone and/or potassium bromide, when gabapentin is added to the therapeutic regimen." | 1.33 | Improving seizure control in dogs with refractory epilepsy using gabapentin as an adjunctive agent. ( Govendir, M; Malik, R; Perkins, M, 2005) |
| "Owners recorded seizure activity and side effects during this period in a standardised diary." | 1.33 | Improving seizure control in dogs with refractory epilepsy using gabapentin as an adjunctive agent. ( Govendir, M; Malik, R; Perkins, M, 2005) |
| "In some dogs, seizures were prevented completely, while in others there was an increase in interictal period." | 1.33 | Improving seizure control in dogs with refractory epilepsy using gabapentin as an adjunctive agent. ( Govendir, M; Malik, R; Perkins, M, 2005) |
| "In vivo, it potently prevents seizures, pain-related behaviors and has anxiolytic-like activity in rodent models." | 1.33 | Activity profile of pregabalin in rodent models of epilepsy and ataxia. ( Bertram, E; Kinsora, JJ; Radulovic, LL; Serpa, KA; Taylor, CP; Vartanian, MG; Vergnes, M, 2006) |
| "In the immature hippocampus, seizures generated with functional GABAergic synapses include fast oscillations that are required to transform a naive network to an epileptic one: blocking GABA receptors prevents the long-lasting sequels of seizures." | 1.33 | Epileptogenic actions of GABA and fast oscillations in the developing hippocampus. ( Ben-Ari, Y; Gozlan, H; Khalilov, I; Le Van Quyen, M, 2005) |
| "In vigabatrin-treated animals, GABA synthesis was 28% lower compared to controls [p < 0." | 1.33 | Evidence that GAD65 mediates increased GABA synthesis during intense neuronal activity in vivo. ( Battaglioli, G; Behar, KL; de Graaf, RA; Martin, DL; Patel, AB, 2006) |
| "Flurothyl was used to induce multiple recurrent seizures in rat pups during the first postnatal days." | 1.33 | Selective impairment of GABAergic synaptic transmission in the flurothyl model of neonatal seizures. ( Holmes, GL; Isaev, D; Isaeva, E; Khazipov, R, 2006) |
| "Neonatal seizures can result in long-term adverse consequences including alteration of seizure susceptibility and impairment in spatial memory." | 1.33 | Selective impairment of GABAergic synaptic transmission in the flurothyl model of neonatal seizures. ( Holmes, GL; Isaev, D; Isaeva, E; Khazipov, R, 2006) |
| "Recurrent spontaneous motor seizures after repeated low-dose systemic treatment with kainate: assessment of a rat model of temporal lobe epilepsy." | 1.33 | Intranigral transplants of immortalized GABAergic cells decrease the expression of kainic acid-induced seizures in the rat. ( Castillo, CG; Freed, WJ; Giordano, M; Mendoza, S, 2006) |
| "Seizures were detected by continuous electroencephalographic monitoring for 24 h following permanent middle cerebral artery occlusion (MCAo)." | 1.33 | Evaluation of gabapentin and ethosuximide for treatment of acute nonconvulsive seizures following ischemic brain injury in rats. ( Bautista, CC; Chen, RW; Dave, JR; Hartings, JA; Lu, XC; Tortella, FC; Williams, AJ, 2006) |
| "Acute seizures following brain injury have been associated with a worsening of patient outcome, but they are often undiagnosed and untreated when they occur without motor convulsions." | 1.33 | Evaluation of gabapentin and ethosuximide for treatment of acute nonconvulsive seizures following ischemic brain injury in rats. ( Bautista, CC; Chen, RW; Dave, JR; Hartings, JA; Lu, XC; Tortella, FC; Williams, AJ, 2006) |
| "Chronic transauricular kindled seizures was induced by repeated application of initially subconvulsive electrical stimulation through ear-clip electrodes once every 24 h until the occurrence of 3 consecutive clonic-tonic seizures." | 1.33 | [Effect of chronic transauricular kindled seizures on passive-avoidance test memory retention in rats]. ( Chen, Z; Li, Q; Liu, LY; Zhou, WX; Zhu, YY, 2006) |
| "Chronic transauricular kindled seizures impaired passive-avoidance test memory retention in rats." | 1.33 | [Effect of chronic transauricular kindled seizures on passive-avoidance test memory retention in rats]. ( Chen, Z; Li, Q; Liu, LY; Zhou, WX; Zhu, YY, 2006) |
| "Chronic transauricular kindled seizure impaired passive-avoidance test memory retention, and it might be due to the damaged CA1 neurons and a decrease of histamine in the hippocampus induced by epilepsy." | 1.33 | [Effect of chronic transauricular kindled seizures on passive-avoidance test memory retention in rats]. ( Chen, Z; Li, Q; Liu, LY; Zhou, WX; Zhu, YY, 2006) |
| "Limbic seizures were evoked in freely moving rats by intrahippocampal administration of pilocarpine via a microdialysis probe." | 1.33 | Substantia nigra is an anticonvulsant site of action of topiramate in the focal pilocarpine model of limbic seizures. ( Clinckers, R; Ebinger, G; Meurs, A; Michotte, Y; Smolders, I, 2006) |
| "At 12 h after seizure on-set, the densities of both SSADH and SSAR immunoreactivities were begun to recover to the pre-seizure level of SS gerbils." | 1.32 | The altered expression of GABA shunt enzymes in the gerbil hippocampus before and after seizure generation. ( An, SJ; Baek, NI; Choi, SY; Hwang, IK; Kang, TC; Kwon, OS; Lee, HY; Park, SK; Won, MH, 2003) |
| "Hypoxia of the brain may alter further seizure susceptibility in a different way." | 1.32 | The epileptogenic effect of seizures induced by hypoxia: the role of NMDA and AMPA/KA antagonists. ( Rubaj, A; Sieklucka-Dziuba, M; Zgodziński, W, 2003) |
| "However, hyperammonemia-induced convulsions were inhibited by GABA in a dose-dependent manner." | 1.32 | Inhibition of acute hyperammonemia-induced convulsions by systemically administered gamma aminobutyric acid in rats. ( Paul, V, 2003) |
| "Gastrodin reduced the seizure score in the treated group, although the immunoreactivities of GABA synthetic enzymes and GABA transporters were unaltered in gastrodin-treated animals." | 1.32 | Gastrodin decreases immunoreactivities of gamma-aminobutyric acid shunt enzymes in the hippocampus of seizure-sensitive gerbils. ( An, SJ; Baek, NI; Choi, SY; Hwang, IK; Jung, SJ; Kang, TC; Kim, SK; Kwon, OS; Lee, HY; Park, SK; Won, MH, 2003) |
| "Thus seizures compromise a delicate balance of excitation and inhibition, on which a complex interaction of different neurotransmitters emerges to counteract excitation at pre- and postsynaptic sites." | 1.32 | Activity-dependent induction of multitransmitter signaling onto pyramidal cells and interneurons of hippocampal area CA3. ( Gutiérrez, R; Maqueda, J; Morales, MA; Romo-Parra, H; Vivar, C, 2003) |
| "Garenoxacin did not induce any convulsions at intravenous doses up to 60 mg/kg in combination with 200 mg/kg oral administration of fenbufen in mice, and its convulsant activity was weaker than those of enoxacin, norfloxacin, ciprofloxacin, alatrofloxacin and ofloxacin." | 1.32 | Pharmacological evaluation of garenoxacin, a novel des-F(6)-quinolone antimicrobial agent: effects on the central nervous system. ( Fukuda, H; Kawamura, Y; Morita, Y; Nakamura, T; Soumi, K, 2003) |
| "Clinical findings include mild-moderate mental retardation, disproportionate language dysfunction, hypotonia, hyporeflexia, autistic behaviors, seizures, and hallucinations." | 1.32 | Clinical spectrum of succinic semialdehyde dehydrogenase deficiency. ( Acosta, MT; Berry, GT; Conry, JA; Gibson, KM; Gropman, A; Novotny, EJ; Pearl, PL; Rogawski, MA; Theodore, WH; Tuchman, M; Vezina, LG, 2003) |
| "Seizures were induced in rats by intraperitoneal injection of pentylenetetrazole (PTZ, 70 mg/kg), followed, 30 min later, by injection of [1-13C]glucose and [1,2-13C]acetate." | 1.32 | Pentylenetetrazole decreases metabolic glutamate turnover in rat brain. ( Dahl, CB; Eloqayli, H; Götestam, KG; Hadidi, H; Sonnewald, U; Unsgård, G, 2003) |
| "Nicotine-induced seizures were blocked by cotreatment with either the nonselective antagonist mecamylamine or the alpha7*-selective antagonist methyllycaconitine." | 1.32 | GABAergic systems modulate nicotinic receptor-mediated seizures in mice. ( Collins, AC; Dobelis, P; Hutton, S; Lu, Y, 2003) |
| "Tetanically induced seizure-like afterdischarge was always preceded by a GABAergic, slow posttetanic depolarization in the pyramidal cells of the original seizure-generating region." | 1.32 | Glutamatergic propagation of GABAergic seizure-like afterdischarge in the hippocampus in vitro. ( Fujiwara-Tsukamoto, Y; Isomura, Y; Takada, M, 2003) |
| "(a) The minimal substrate of SW seizures is the neocortex because such seizures may occur in thalamectomized animals, in which spindles are absent." | 1.32 | Sleep oscillations developing into seizures in corticothalamic systems. ( Amzica, F; Steriade, M, 2003) |
| "Gabapentin was also effective against two other bs mutants, bangsenseless(1) and slamdance(iso7." | 1.32 | Treatment with the antiepileptic drugs phenytoin and gabapentin ameliorates seizure and paralysis of Drosophila bang-sensitive mutants. ( Feeney, L; Jacobs, B; McKeever, C; Reynolds, ER; Rojahn, E; Stauffer, EA, 2004) |
| "In a physiological preparation, seizures and failures corresponding to the defective behavior are observed in response to high frequency stimulation." | 1.32 | Treatment with the antiepileptic drugs phenytoin and gabapentin ameliorates seizure and paralysis of Drosophila bang-sensitive mutants. ( Feeney, L; Jacobs, B; McKeever, C; Reynolds, ER; Rojahn, E; Stauffer, EA, 2004) |
| "The immature brain is prone to seizures but the underlying mechanisms are poorly understood." | 1.32 | Developmental changes in GABAergic actions and seizure susceptibility in the rat hippocampus. ( Ben-Ari, Y; Holmes, GL; Khalilov, I; Khazipov, R; Morozova, E; Tyzio, R, 2004) |
| "At 12h after seizure on-set, Na(+)-K(+) ATPase expression was re-enhanced in the all regions of the hippocampal complex including the dentate hilus." | 1.32 | Altered Na+-K+ ATPase immunoreactivity within GABAergic neurons in the gerbil hippocampal complex induced by spontaneous seizure and vigabatrin treatment. ( An, SJ; Hwang, IK; Kang, TC; Park, SK; Won, MH, 2004) |
| "Nonconvulsive seizures (NCSs) after traumatic and ischemic brain injury are often refractory to antiepileptic drug therapy and are associated with a decline in patient outcome." | 1.32 | Antiepileptic drug treatment of nonconvulsive seizures induced by experimental focal brain ischemia. ( Hartings, JA; Lu, XM; Moreton, JE; Tortella, FC; Williams, AJ, 2004) |
| "It remains unclear whether the seizures result from aberrant neuronal placement, disruption of intrinsic properties of neurons, or both." | 1.32 | Epileptic-like convulsions associated with LIS-1 in the cytoskeletal control of neurotransmitter signaling in Caenorhabditis elegans. ( Braden, AL; Caldwell, GA; Caldwell, KA; Locke, CJ; Williams, SN, 2004) |
| "Identical convulsions were obtained using C." | 1.32 | Epileptic-like convulsions associated with LIS-1 in the cytoskeletal control of neurotransmitter signaling in Caenorhabditis elegans. ( Braden, AL; Caldwell, GA; Caldwell, KA; Locke, CJ; Williams, SN, 2004) |
| "Spontaneous recurrent seizures were monitored with Racine's seizure severity scale." | 1.32 | Human neural stem cell transplantation reduces spontaneous recurrent seizures following pilocarpine-induced status epilepticus in adult rats. ( Chu, K; Jeon, D; Jeong, SW; Jung, KH; Kim, J; Kim, M; Kim, SU; Lee, SK; Lee, ST; Roh, JK; Shin, HS, 2004) |
| "Vigabatrin (10 microg) was injected 24 h before the first stimulation as well as 6 h before the 5th and 10th stimulation, which approximately doubled the number of stimulations required for kindling development compared with controls." | 1.32 | Bilateral microinjections of vigabatrin in the central piriform cortex retard amygdala kindling in rats. ( Ebert, U; Löscher, W; Schwabe, K, 2004) |
| "Instead, before kindling, a focal seizure in the Slow rats was associated with a large decrease in GABA in the non-stimulated amygdala, while amino acid levels in the Fast rats remained near baseline in both amygdalae." | 1.31 | Changes in extracellular levels of amygdala amino acids in genetically fast and slow kindling rat strains. ( Anisman, H; McIntyre, DC; Merali, Z; Shin, RS, 2002) |
| "Electroconvulsions were produced by means of an alternating current (ear-clip electrodes, 0." | 1.31 | Effect of gabapentin on the anticonvulsant activity of antiepileptic drugs against electroconvulsions in mice: an isobolographic analysis. ( Borowicz, KK; Czuczwar, SJ; Luszczki, J; Swiader, M, 2002) |
| "Gabapentin (GBP) is a gamma-aminobutyric acid analog effective in the treatment of seizures." | 1.31 | Long-term regulation of voltage-gated Ca(2+) channels by gabapentin. ( Campbell, KP; Felix, R; Kang, MG, 2002) |
| "With the use of well defined animal seizure models, Con-R was found to possess an anticonvulsant profile superior to that of ifenprodil and dizocilpine (MK-801)." | 1.31 | In vitro and in vivo characterization of conantokin-R, a selective NMDA receptor antagonist isolated from the venom of the fish-hunting snail Conus radiatus. ( Abogadie, FC; Armstrong, H; Cruz, LJ; Donevan, SD; Hollmann, M; McCabe, RT; Olivera, BM; Paarmann, I; Rivier, JE; Torres, J; White, HS, 2000) |
| "GABA is crucial in the generation of absence seizures." | 1.31 | Selective susceptibility to inhibitors of GABA synthesis and antagonists of GABA(A) receptor in rats with genetic absence epilepsy. ( Boehrer, A; Marescaux, C; Reibel, S; Simler, S; Vergnes, M, 2000) |
| "In the seizure studies, GRP (30-300 ng) increased the latency to tonic seizure, the number of mice convulsing and reduced the incidence of lethality." | 1.31 | Effect of gastrin-releasing peptide on rat hippocampal extracellular GABA levels and seizures in the audiogenic seizure-prone DBA/2 mouse. ( Andrews, N; Davis, B; Gonzalez, MI; McKnight, AT; Oles, R; Singh, L, 2000) |
| "When the threshold for secondary generalized seizures (GST) was determined in addition to ADT, gabapentin and levetiracetam strikingly increased this threshold compared to predrug control." | 1.31 | Anticonvulsant efficacy of gabapentin and levetiracetam in phenytoin-resistant kindled rats. ( Ebert, U; Löscher, W; Reissmüller, E, 2000) |
| "p." | 1.31 | Guanosine and GMP prevent seizures induced by quinolinic acid in mice. ( da Silveira Perla, A; de Faria Maraschin, J; Lara, DR; Onofre Souza, D; Schmidt, AP, 2000) |
| "Bicuculline was used to investigate seizure susceptibility in pre- and peripubertal male and female rats exposed prenatally to morphine." | 1.31 | Prenatal morphine exposure alters susceptibility to bicuculline seizures in a sex- and age-specific manner. ( Schindler, CJ; Slamberová, R; Vathy, I; Velísková, J, 2000) |
| "Gabapentin has been shown to reduce paired-pulse inhibition in the dentate gyrus of the urethane-anesthetized rat and has been shown to block calcium channels, but its not known how these possible mechanisms relate to its antiepileptic effect." | 1.31 | The effects of gabapentin in the rat hippocampus are mimicked by two structural analogs, but not by nimodipine. ( Stringer, JL; Taylor, CP, 2000) |
| "Seizures were evoked with pilocarpine (400 mg/kg, i." | 1.31 | The effect of CGP-40116 on pilocarpine evoked seizures in mice exposed to transient episode of brain ischemia. ( Czuczwar, SJ; Kleinrok, Z; Rejdak, K; Rejdak, R; Sieklucka-Dziuba, M; Stelmasiak, Z, 2000) |
| "Sound induced convulsions in DBA/2 mice were dose-dependently inhibited by all compounds (administered intraperitoneal, i." | 1.31 | GABA-level increasing and anticonvulsant effects of three different GABA uptake inhibitors. ( Dalby, NO, 2000) |
| "A significant decrease in seizure susceptibility could be observed in BCCA treated mice compared with sham-operated controls." | 1.31 | The influence of MK-801 on bicuculline evoked seizures in adult mice exposed to transient episode of brain ischemia. ( Kleinrok, Z; Rejdak, K; Rejdak, R; Sieklucka-Dziuba, M, 2000) |
| "Kainic acid (KA) was administered to rats on postnatal day (P) 35." | 1.31 | Anticonvulsant action and long-term effects of gabapentin in the immature brain. ( Bolanos, AR; Cilio, MR; Holmes, GL; Liu, Z; Mikati, MA; Schmid, R; Stafstrom, CE; Yang, Y, 2001) |
| "Effectiveness of GBP on seizure threshold was tested using flurothyl inhalation in 10 separate age groups of animals ranging from the newborn period to adulthood." | 1.31 | Anticonvulsant action and long-term effects of gabapentin in the immature brain. ( Bolanos, AR; Cilio, MR; Holmes, GL; Liu, Z; Mikati, MA; Schmid, R; Stafstrom, CE; Yang, Y, 2001) |
| "However, after kindled seizures, GluRAs block the monosynaptic excitatory postsynaptic potential (EPSP) and isolate a monosynaptic inhibitory postsynaptic potential (IPSP), suggesting that mossy fibers release GABA." | 1.31 | Seizures induce simultaneous GABAergic and glutamatergic transmission in the dentate gyrus-CA3 system. ( Gutiérrez, R, 2000) |
| "The purpose of the present investigation was to determine whether the sensitivity to systemic toxic effects of cocaine is altered in genetically epilepsy-prone rats (GEPRs)." | 1.31 | Phenotypic expression of the systemic toxicity of cocaine in genetically epilepsy-prone rats. ( Heavner, JE; Kao, YJ; Kaye, AD; Reigel, CE; Shi, B, 2000) |
| "Moderate seizure (GEPR-3) and severe seizure (GEPR-9) rats, and the control strain, Sprague-Dawley rats, 10 weeks of age, were lightly anesthetized with halothane and nitrous oxide." | 1.31 | Phenotypic expression of the systemic toxicity of cocaine in genetically epilepsy-prone rats. ( Heavner, JE; Kao, YJ; Kaye, AD; Reigel, CE; Shi, B, 2000) |
| "Chronic seizures were induced by amygdalar injection of kainic acid 60 days before death." | 1.31 | Collapse of extracellular glutamate regulation during epileptogenesis: down-regulation and functional failure of glutamate transporter function in rats with chronic seizures induced by kainic acid. ( Doi, T; Kamada, H; Mitsuyama, Y; Nakajima, A; Ohya-Nishiguchi, H; Tokumaru, J; Ueda, Y; Willmore, LJ; Yokoyama, H, 2001) |
| "The cause of theophylline-induced convulsions is not clear, but antagonism of the inhibitory nervous system may be implicated, so we examined the effects of theophylline on GABA-induced currents using recombinant GABA(A) receptor (GABA(A)-R)." | 1.31 | Inhibitory effect of theophylline on recombinant GABA(A) receptor. ( Mashimo, T; Okada, S; Sugimoto, M; Sugimoto, T; Uchida, I, 2001) |
| "Though displaying no spontaneous seizure activity, these mice exhibit altered electroencephalographic patterns and increased susceptibility to seizure induced by kainic acid." | 1.31 | Overexpression of gamma-aminobutyric acid transporter subtype I leads to susceptibility to kainic acid-induced seizure in transgenic mice. ( Fei, J; Guo, LH; Hu, JH; Ma, Y; Mei, ZT; Yu, Y; Zhao, WJ; Zhou, XG, 2001) |
| "Immunization with the whole-cell pertussis vaccine (Pw), while effective at preventing whooping cough in infants, has been associated with local, systemic, and neuronal reactions, including fevers and convulsions in children." | 1.31 | Whole-cell but not acellular pertussis vaccines induce convulsive activity in mice: evidence of a role for toxin-induced interleukin-1beta in a new murine model for analysis of neuronal side effects of vaccination. ( Donnelly, S; Loscher, CE; Lynch, MA; Mills, KH, 2001) |
| "Kindled seizures were produced on day 16 of life by repeatedly applying an electrical current stimulus to the amygdala electrode." | 1.31 | Anticonvulsant efficacy of gabapentin on kindling in the immature brain. ( Lado, FA; Moshé, SL; Sperber, EF, 2001) |
| "A partial but significant inhibition of convulsions was found in these animals." | 1.31 | Evidence for an involvement of the ammonia-decreasing action of L-arginine in suppressing picrotoxin-induced convulsions in rats and its additive action with diazepam. ( Jayakumar, AR; Vanaja, P, 2001) |
| "The interval until convulsion due to picrotoxin was also prolonged by the administration of DMP combined with diazepam and valproic acid (VPA)." | 1.31 | Effect of alkylpyrazine derivatives on the duration of pentobarbital-induced sleep, picrotoxicin-induced convulsion and gamma-aminobutyric acid (GABA) levels in the mouse brain. ( Aoyagi, Y; Ohta, A; Watanabe, Y; Yamada, K, 2001) |
| "Testosterone's (T) anti-seizure effects may be mediated in part by actions of its 5alpha-reduced metabolites." | 1.31 | Testosterone reduces pentylenetetrazole-induced ictal activity of wildtype mice but not those deficient in type I 5alpha-reductase. ( Frye, CA; Harney, JP; Rhodes, ME; Walf, AA, 2001) |
| "The blonanserin-potentiation was not reversed by flumazenil." | 1.31 | The effects of neuroleptics on the GABA-induced Cl- current in rat dorsal root ganglion neurons: differences between some neuroleptics. ( Fukuda, A; Matsuno, T; Matsuo, T; Motomura, H; Shoge, T; Tashiro, N; Tatebayashi, H; Yokota, K, 2002) |
| "Limbic seizures were provoked in freely moving rats by intrahippocampal administration of the muscarinic receptor agonist pilocarpine via a microdialysis probe (10 mM for 40 min at 2 microliters/min)." | 1.30 | Hippocampal and cerebellar extracellular amino acids during pilocarpine-induced seizures in freely moving rats. ( Ebinger, G; Michotte, Y; Smolders, I; Van Belle, K, 1997) |
| "CRF itself can produce limbic seizures which resemble kindling in some aspects." | 1.30 | Amygdala-kindled seizures increase the expression of corticotropin-releasing factor (CRF) and CRF-binding protein in GABAergic interneurons of the dentate hilus. ( Berry, RL; Clark, M; Massenburg, G; Post, RM; Smith, MA; Weiss, SR; Zhang, LX, 1997) |
| "Epilepsy is a common condition in people with learning disabilities with many patients continuing to suffer from seizures despite antiepileptic drug (AED) treatment." | 1.30 | A naturalistic study of the use of vigabatrin, lamotrigine and gabapentin in adults with learning disabilities. ( Bhaumik, S; Branford, D; Duggirala, C; Ismail, IA, 1997) |
| "Lamotrigine caused increased seizures in 24% of patients, especially when prescribed at a higher dose." | 1.30 | A naturalistic study of the use of vigabatrin, lamotrigine and gabapentin in adults with learning disabilities. ( Bhaumik, S; Branford, D; Duggirala, C; Ismail, IA, 1997) |
| " In the present study, the effects of maternal cocaine dosage and of cocaine-elicited maternal seizures on the progeny were studied." | 1.30 | Cocaine administration in pregnant rabbits alters cortical structure and function in their progeny in the absence of maternal seizures. ( Fischer, I; Friedman, E; Grayson, D; Jones, L; Levitt, P; Murphy, EH; O'Brien-Jenkins, A; Wang, HY; Wang, XH, 1997) |
| "The incidence of maternal generalized tonic clonic seizures (GTCSs) elicited by cocaine was recorded." | 1.30 | Cocaine administration in pregnant rabbits alters cortical structure and function in their progeny in the absence of maternal seizures. ( Fischer, I; Friedman, E; Grayson, D; Jones, L; Levitt, P; Murphy, EH; O'Brien-Jenkins, A; Wang, HY; Wang, XH, 1997) |
| "In addition to the seizure model, we tested the three new anti-epileptic drugs for an effect on excitability, on paired-pulse inhibition and on long-term potentiation (LTP) in the dentate gyrus of the urethane-anesthetized rat." | 1.30 | Effects of felbamate, gabapentin and lamotrigine on seizure parameters and excitability in the rat hippocampus. ( Stringer, JL; Xiong, ZQ, 1997) |
| "Pilocarpine-induced seizures are initiated via muscarinic receptors and further mediated via NMDA receptors." | 1.30 | NMDA receptor-mediated pilocarpine-induced seizures: characterization in freely moving rats by microdialysis. ( Ebinger, G; Khan, GM; Manil, J; Michotte, Y; Smolders, I, 1997) |
| "2." | 1.30 | NMDA receptor-mediated pilocarpine-induced seizures: characterization in freely moving rats by microdialysis. ( Ebinger, G; Khan, GM; Manil, J; Michotte, Y; Smolders, I, 1997) |
| "A single seizure resulted in three phases of post-ictal changes in glutamate and GABA levels: during phase I, there were transient increases in both glutamate and GABA whilst in phase II, levels of both amino acids were reduced." | 1.30 | Generalised seizure-induced changes in rat hippocampal glutamate but not GABA release are potentiated by repeated seizures. ( Marsden, CA; Martin, KF; Rowley, HL, 1997) |
| "However, the seizure-suppressing effect of GABAergic grafts was not permanent but slowly disappeared over the weeks after transplantation." | 1.30 | Seizure suppression in kindling epilepsy by grafts of fetal GABAergic neurons in rat substantia nigra. ( Ebert, U; Lehmann, H; Löscher, W; Nikkhah, G; Rosenthal, C, 1998) |
| "Vigabatrin is a new antiepileptic medication consisting of a racemic mixture of 50% active S enantiomer and 50% inactive R enantiomer." | 1.30 | Vigabatrin: placental transfer in vivo and excretion into breast milk of the enantiomers. ( Mai, J; Mumford, JP; O'Mahoney, T; Olive, G; Rey, E; Tran, A, 1998) |
| " Both effects exhibited a tendency to a U-shaped dose-response curve." | 1.30 | Anticonvulsant action of gabapentin during postnatal development in rats. ( Haugvicová, R; Mares, P, 1997) |
| "Motor seizures were induced by pentylenetetrazol in 7-, 12-, 18-, 25-day-old, and adult rats." | 1.30 | Anticonvulsant action of gabapentin during postnatal development in rats. ( Haugvicová, R; Mares, P, 1997) |
| "In addition, minimal seizures were suppressed in 18-day-old rats." | 1.30 | Anticonvulsant action of gabapentin during postnatal development in rats. ( Haugvicová, R; Mares, P, 1997) |
| "When information became available on aplastic anemia and hepatotoxicity associated with felbamate, all patients were advised to taper their felbamate dosage over approximately 2 weeks." | 1.30 | Increased seizure frequency associated with felbamate withdrawal in adults. ( Privitera, M; Shukla, R; Welty, TE, 1998) |
| "To characterize changes in seizure frequency following felbamate withdrawal." | 1.30 | Increased seizure frequency associated with felbamate withdrawal in adults. ( Privitera, M; Shukla, R; Welty, TE, 1998) |
| "Changes in seizure frequency were evaluated by comparing the number of seizures in the month felbamate was tapered and the 3 months after felbamate discontinuation with the baseline frequency." | 1.30 | Increased seizure frequency associated with felbamate withdrawal in adults. ( Privitera, M; Shukla, R; Welty, TE, 1998) |
| "The generalized convulsion started at about 1." | 1.30 | Changes in extracellular glutamate and GABA levels in the hippocampal CA3 and CA1 areas and the induction of glutamic acid decarboxylase-67 in dentate granule cells of rats treated with kainic acid. ( Asada, H; Ding, R; Obata, K, 1998) |
| "A patient with hepatic cirrhosis due to Alpers disease is described who had a significantly raised plasma alanine aminotransferase (ALT) activity of 247 U/L which returned to normal (18 U/L) shortly after commencing treatment with the anticonvulsant drug, vigabatrin." | 1.30 | Suppression of elevated alanine aminotransferase activity in liver disease by vigabatrin. ( Coakley, J; Sekaninova, S; Williams, A, 1998) |
| "Minimal seizures were not affected by solvent or progabide pretreatment." | 1.30 | Anticonvulsant effect of progabide in rats during ontogenesis. ( Kozuchová, A; Mares, P; Stanková, L, 1997) |
| "The action of progabide against motor seizures elicited by pentylenetetrazol was studied in 7-, 12-, 18-, 25-day-old and adult rats." | 1.30 | Anticonvulsant effect of progabide in rats during ontogenesis. ( Kozuchová, A; Mares, P; Stanková, L, 1997) |
| "SL 75 102 suppressed generalized tonic-clonic seizures in adult rats and restricted the tonic phase of these seizures in rat pups." | 1.30 | Anticonvulsant effect of SL 75 102 in adult and immature rats. ( Haugvicová, R; Kubová, H; Mares, P, 1997) |
| "Convulsions were prevented by intrastriatal preinjection of muscimol." | 1.30 | Pharmacological evidence for GABAergic and glutamatergic involvement in the convulsant and behavioral effects of glutaric acid. ( Begnini, J; de Bastiani, J; de Mello, CF; Fialho, DB; Jurach, A; Lima, TT; Ribeiro, MC; Wajner, M, 1998) |
| "Limbic motor seizures in animals, analogous to complex partial seizures in humans, result in a consistent activation of the mediodorsal thalamus (MD) and, with prolonged seizures, damage to MD." | 1.30 | Mediodorsal thalamus plays a critical role in the development of limbic motor seizures. ( Cassidy, RM; Gale, K, 1998) |
| "0 mg/kg dosage of 3 alpha,5 alpha-THP." | 1.30 | Prenatal stress reduces the effectiveness of the neurosteroid 3 alpha,5 alpha-THP to block kainic-acid-induced seizures. ( Bayon, LE; Frye, CA, 1999) |
| "One week after seizures, there were no differences in the water maze performance of the remaining animals." | 1.30 | Prenatal stress reduces the effectiveness of the neurosteroid 3 alpha,5 alpha-THP to block kainic-acid-induced seizures. ( Bayon, LE; Frye, CA, 1999) |
| "Theophylline elicited tonic seizures in mice in a dose dependent manner." | 1.30 | Gamma-aminobutyric acid and glutamic acid receptors may mediate theophylline-induced seizures in mice. ( Amabeoku, GJ, 1999) |
| "In mice with convulsions, the inhibitory profiles of the threshold concentrations of both drugs in brain tissue of mice with convulsions and those without convulsions can be predicted quantitatively by using in vitro GABA response data and toxicodynamic model." | 1.30 | In vivo and in vitro toxicodynamic analyses of new quinolone-and nonsteroidal anti-inflammatory drug-induced effects on the central nervous system. ( Asanuma, A; Iga, T; Kawakami, J; Kita, H; Matsuo, H; Naito, M; Sawada, Y; Takanaga, H; Tsuruo, T; Yamamoto, K; Yanagisawa, K, 1999) |
| "Furthermore, SPD 502 increased the seizure threshold for electroshock-induced tonic seizures in mice at i." | 1.30 | SPD 502: a water-soluble and in vivo long-lasting AMPA antagonist with neuroprotective activity. ( Drejer, J; Gouliaev, AH; Jensen, LH; Mathiesen, C; Moller, A; Nielsen, EO; Varming, T; Wätjen, F, 1999) |
| "Investigations were carried out to evaluate the effect of acute and chronic administration of both black and green tea on three models of experimentally induced convulsions in mice." | 1.30 | Proconvulsive effect of tea (Camellia sinensis) in mice. ( Das, M; Ganguly, DK; Gomes, A; Vedasiromoni, JR, 1999) |
| "Ten minutes later, seizure activity was induced by either a focal microinfusion of bicuculline methiodide (177 pmol) into the rostral piriform cortex, systemic PTZ (50 mg/kg, i." | 1.30 | Regulation of limbic motor seizures by GABA and glutamate transmission in nucleus tractus solitarius. ( Easton, A; Gale, K; Walker, BR, 1999) |
| "Bicuculline plus cyclosporine-induced convulsions were significantly suppressed by an activation of GABAergic transmission with diazepam, phenobarbital and valproate." | 1.30 | Inhibition of GABA system involved in cyclosporine-induced convulsions. ( Fujisaki, K; Fujiwara, M; Kataoka, Y; Miura, I; Nakao, T; Oishi, R; Shuto, H; Sueyasu, M; Watanabe, Y, 1999) |
| " DZP and HAL dose-response curves (0, 0." | 1.30 | Effects of diazepam or haloperidol on convulsion and behavioral responses induced by bilateral electrical stimulation in the medial prefrontal cortex. ( de Oliveira, RW; Gomes, CF; Nakamura-Palacios, EM, 1999) |
| "5." | 1.30 | Effects of diazepam or haloperidol on convulsion and behavioral responses induced by bilateral electrical stimulation in the medial prefrontal cortex. ( de Oliveira, RW; Gomes, CF; Nakamura-Palacios, EM, 1999) |
| "A partial but significant inhibition of convulsion responses was found in these animals." | 1.30 | Effects of L-arginine on picrotoxin-induced increase in brain ammonia concentrations and convulsions in rats. ( Jayakumar, AR; Paul, V, 1999) |
| "All animals were tested three times for seizure threshold, and were then decapitated and the brains removed for analysis of the amino acids." | 1.30 | Effects of ammonia on pentylenetetrazole-induced seizure threshold. ( Arikan, K; Coskun, T; Guvener, B; Oran, O, 1999) |
| " In the flurothyl seizure model, SNR microinjection of the selective GABAA receptor agonist muscimol results in a biphasic dose-response curve in adults: Intermediate doses are anticonvulsant, but high doses have proconvulsant effects." | 1.29 | Age-related differences in the effects of GABAA agonists microinjected into rat substantia nigra: pro- and anticonvulsant actions. ( Garant, DS; Moshé, SL; Sperber, EF; Xu, SG, 1995) |
| "In the flurothyl seizure model, SNR microinjection of the selective GABAA receptor agonist muscimol results in a biphasic dose-response curve in adults: Intermediate doses are anticonvulsant, but high doses have proconvulsant effects." | 1.29 | Age-related differences in the effects of GABAA agonists microinjected into rat substantia nigra: pro- and anticonvulsant actions. ( Garant, DS; Moshé, SL; Sperber, EF; Xu, SG, 1995) |
| "Behavioral characteristics of seizures have age-dependent features, which suggests that effective treatment of seizures may be age-specific as well." | 1.29 | Age-dependent effects of gamma-aminobutyric acid agents on flurothyl seizures. ( Moshé, SL; Ortíz, J; Ptachewich, Y; Shinnar, S; Velísek, L; Velísková, J, 1995) |
| "The data suggest that seizure-prone BALB/c mice have a deficiency in intracellular content of both excitatory and inhibitory amino acids." | 1.29 | Determination of amino acids and monoamine neurotransmitters in caudate nucleus of seizure-resistant and seizure-prone BALB/c mice. ( Alexiuk, NA; Green-Johnson, J; Ryan, E; Vriend, J, 1993) |
| "PTZ-induced convulsions were partly antagonized by the GVG treatment." | 1.29 | The significance of extracellular GABA in the substantia nigra of the rat during seizures and anticonvulsant treatments. ( Sayin, U; Timmerman, W; Westerink, BH, 1995) |
| "tended to decrease seizure intensity and at a dose of 10 mg/kg was ineffective at all." | 1.29 | Further evidence for the interactions between angiotensin II and GABAergic transmission in pentylenetetrazol kindling seizures in mice. ( Georgiev, VP; Kambourova, TS; Lazarova, MB, 1995) |
| ", significantly lowered the convulsive threshold of pentylenetetrazol (PTZ) in mice and shifted the dose-response curve of PTZ." | 1.29 | Correlation between in vitro and in vivo models of proconvulsive activity with the carbapenem antibiotics, biapenem, imipenem/cilastatin and meropenem. ( Day, IP; Goudie, J; Nishiki, K; Williams, PD, 1995) |
| "We simultaneously monitored the seizure-related changes in extracellular hippocampal glutamate (Glu) and gamma-aminobutyric acid (GABA) concentration in brain dialysates in order to clarify the role of Glu and GABA in the development of kindling." | 1.29 | Simultaneous monitoring of the seizure-related changes in extracellular glutamate and gamma-aminobutyric acid concentration in bilateral hippocampi following development of amygdaloid kindling. ( Tsuru, N; Ueda, Y, 1995) |
| "Isoguvacine pre-treatment prevented the increase in DOPAC concentrations in the median eminence produced by SR 95531." | 1.29 | GABAergic regulation of tuberoinfundibular dopaminergic neurons in the male rat. ( Goudreau, JL; Lookingland, KJ; Moore, KE; Wagner, EJ, 1994) |
| "Susceptibility to audiogenic seizures (AGS) is observed during ethanol withdrawal (ETX)." | 1.29 | Increased responsiveness of pontine reticular formation neurons associated with audiogenic seizure susceptibility during ethanol withdrawal. ( Faingold, CL; Riaz, A, 1994) |
| "Susceptibility to audiogenic seizures (AGS) was investigated in Sprague-Dawley rats subjected to cardiac arrest cerebral ischemia (CACI), produced by compression of the major cardiac vessels." | 1.29 | Development of susceptibility to audiogenic seizures following cardiac arrest cerebral ischemia in rats. ( Kawahara, N; Kawai, K; Klatzo, I; Penix, LP; Ruetzler, CA, 1995) |
| "Pyrimethamine dose dependently induced seizures in mice." | 1.29 | GABAergic and dopaminergic systems may be involved in seizures induced by pyrimethamine in mice. ( Amabeoku, G; Chikuni, O, 1994) |
| "Pyridoxine-dependent seizures are a disorder of GABA metabolism probably due to a defective binding of pyridoxal phosphate coenzyme (PALP) with glutamate decarboxylase (GAD), the rate-limiting enzyme in GABA synthesis." | 1.29 | Pyridoxine-dependent seizures associated with white matter abnormalities. ( Giugliani, R; Jardim, LB; Kliemann, FA; Martins, CE; Pires, RF; Vargas, CR; Vizioli, J, 1994) |
| "They also exhibited severe seizure discharge activity of prolonged duration at any given dose of either picrotoxin or pentylene tetrazole." | 1.29 | Picrotoxin and pentylene tetrazole induced seizure activity in pyridoxine-deficient rats. ( Bolster, B; Dakshinamurti, K; Sharma, SK, 1994) |
| "The seizures were divided into four stages according to their severity." | 1.29 | Altered GABAergic effects on kainic acid-induced seizures in the presence of hippocampal sclerosis in rats. ( Araki, T; Goto, I; Kato, M, 1994) |
| "7 days after the induction of acute seizure, the rats were sacrificed and subjected to histological examinations." | 1.29 | Altered GABAergic effects on kainic acid-induced seizures in the presence of hippocampal sclerosis in rats. ( Araki, T; Goto, I; Kato, M, 1994) |
| "Laudanosine was almost ineffective at [3H]muscimol binding to high-affinity GABA receptors (IC50 = 100 microM)." | 1.29 | Interactions between laudanosine, GABA, and opioid subtype receptors: implication for laudanosine seizure activity. ( Fonia, O; Gavish, M; Katz, Y; Liu, L; Pasternak, GW; Pick, CG; Weizman, A, 1994) |
| "Domoic acid (0." | 1.29 | Hippocampal changes in developing postnatal mice following intrauterine exposure to domoic acid. ( Dakshinamurti, K; Sharma, SK; Sundaram, M; Watanabe, T, 1993) |
| "No clinical seizure activity was observed during this period." | 1.29 | Hippocampal changes in developing postnatal mice following intrauterine exposure to domoic acid. ( Dakshinamurti, K; Sharma, SK; Sundaram, M; Watanabe, T, 1993) |
| "DBA/2 mice were more susceptible to seizures induced by cefazolin than were Swiss mice." | 1.29 | Quinolones potentiate cefazolin-induced seizures in DBA/2 mice. ( Chimirri, A; De Sarro, A; De Sarro, GB; Grasso, S; Zappalá, M, 1993) |
| "The running was followed by seizures and sometimes death." | 1.29 | Inhibition of DFMO-induced audiogenic seizures by chlordiazepoxide. ( Fuller, DJ; Gensler, HL; Gerner, EW; Gerrish, KE, 1993) |
| "Clinical seizure activity within 6 months prior to the test seemed to have no obvious effect on the plasma amino acid pattern, except for the levels of glycine and arginine tended to return to normal, and the level of GABA was significantly increased in patients with the seizure being controlled." | 1.29 | Alteration of amino acid in plasma and cerebrospinal fluid of children with seizure disorders. ( Chiang, CH; Chiang, W; Ko, FJ; Liu, WJ, 1993) |
| "Dexmedetomidine and the lower dose of atipamezole (0." | 1.29 | Effect of alpha 2-adrenergic drugs dexmedetomidine and atipamezole on extracellular amino acid levels in vivo. ( Haapalinna, A; Halonen, T; Riekkinen, P; Valtonen, P, 1995) |
| "Gabapentin (GBP) is a new antiepileptic drug (AED) approved for adjunctive treatment of complex partial seizures with or without seizures secondarily generalization in adults." | 1.29 | Gabapentin associated with aggressive behavior in pediatric patients with seizures. ( Lo, W; Nahata, MC; Tallian, KB; Tsao, CY, 1996) |
| "Kainic acid (KA)-induced convulsions are accompanied by histopathological changes that are most prominent in the temporal lobe structures." | 1.29 | Alpha 2-adrenoceptor agonist, dexmedetomidine, protects against kainic acid-induced convulsions and neuronal damage. ( Halonen, T; Kotti, T; Miettinen, R; Riekkinen, PJ; Toppinen, A; Tuunanen, J, 1995) |
| "Gabapentin dose-dependently attenuated myoclonus in posthypoxic rats for more than 3 h." | 1.29 | Antimyoclonic effect of gabapentin in a posthypoxic animal model of myoclonus. ( Kanthasamy, AG; Truong, DD; Vu, TQ; Yun, RJ, 1996) |
| "Seizures associated with intracranial neoplasms are occasionally refractory to conventional anti-epileptic drugs." | 1.29 | Add-on gabapentin for refractory seizures in patients with brain tumours. ( Perry, JR; Sawka, C, 1996) |
| "Complete resolution of seizures occurred in 8/14 patients." | 1.29 | Add-on gabapentin for refractory seizures in patients with brain tumours. ( Perry, JR; Sawka, C, 1996) |
| "To determine whether seizures have age-specific features, we studied the role of gamma-aminobutyric acidB (GABAB) transmission in rats of various ages (9, 15, 30, and 60 postnatal days)." | 1.29 | Age-specific effects of baclofen on pentylenetetrazol-induced seizures in developing rats. ( Moshé, SL; Velísek, L; Velísková, J, 1996) |
| " We conclude that vigabatrin in SSADH deficiency should be administered in a gradually increasing dosage combined with frequent evaluation of the clinical condition and the EEG." | 1.29 | Seizures in a boy with succinic semialdehyde dehydrogenase deficiency treated with vigabatrin (gamma-vinyl-GABA). ( Gibson, KM; Korinthenberg, R; Lehnert, W; Matern, D, 1996) |
| "A stable EEG without the recurrence of seizures as well as renewed improvement of cognitive and behavioural functions was achieved with a reduced vigabatrin dose of 25 mg/kg per day." | 1.29 | Seizures in a boy with succinic semialdehyde dehydrogenase deficiency treated with vigabatrin (gamma-vinyl-GABA). ( Gibson, KM; Korinthenberg, R; Lehnert, W; Matern, D, 1996) |
| "Tonic-clonic seizures were observed in HAGS animals, while LAGS rats exhibited less severe seizures, consisting primarily of wild running." | 1.29 | Decreased GABA effectiveness in the inferior colliculus neurons during ethanol withdrawal in rats susceptible to audiogenic seizures. ( Caspary, DM; Faingold, CL; N'Gouemo, P, 1996) |
| "after seizure induction than for those who received the same field over the left hemisphere or that had been exposed to reference conditions." | 1.29 | Long-term consequences of subtle stimuli during the first twenty-four hours of seizure-induced brain injury. ( Cook, LL; Persinger, MA, 1996) |
| " Generalized tonic-clonic seizures observed in EP mice were inhibited by valproate, administered 1 h prior to testing, in a dose-response fashion." | 1.29 | Effects of valproate on amino acid and monoamine concentrations in striatum of audiogenic seizure-prone Balb/c mice. ( Alexiuk, NA; Vriend, JP, 1996) |
| "Generalized tonic-clonic seizures observed in EP mice were inhibited by valproate, administered 1 h prior to testing, in a dose-response fashion." | 1.29 | Effects of valproate on amino acid and monoamine concentrations in striatum of audiogenic seizure-prone Balb/c mice. ( Alexiuk, NA; Vriend, JP, 1996) |
| "2." | 1.28 | Effects of antiepileptic drugs, calcium channel blockers and other compounds on seizures induced by activation of voltage-dependent L calcium channel in DBA/2 mice. ( Ascioti, C; De Sarro, A; De Sarro, G; di Paola, ED; Vidal, MJ, 1992) |
| "3." | 1.28 | Effects of antiepileptic drugs, calcium channel blockers and other compounds on seizures induced by activation of voltage-dependent L calcium channel in DBA/2 mice. ( Ascioti, C; De Sarro, A; De Sarro, G; di Paola, ED; Vidal, MJ, 1992) |
| "The results are as follows: 1." | 1.28 | [The effect of acupuncture on high oxygen pressure-induced convulsion and its relationship to the brain GABA concentration in mice]. ( Shen, Q; Wu, Y; Zhang, Q, 1992) |
| "Seizure-sensitive (SS) and seizure-resistant (SR) Mongolian gerbils were used for three experiments." | 1.28 | Morphological evidence for altered synaptic organization and structure in the hippocampal formation of seizure-sensitive gerbils. ( Farias, PA; Low, SQ; Peterson, GM; Ribak, CE, 1992) |
| "These audiogenic-like seizures were blocked by clobazam microinjection into the substantia nigra (SN) and partially modified by SN vehicle injection." | 1.28 | Neuroethological evaluation of audiogenic seizures and audiogenic-like seizures induced by microinjection of bicuculline into the inferior colliculus. II. Effects of nigral clobazam microinjections. ( Garcia-Cairasco, N; Terra, VC, 1992) |
| "Audiogenic seizures (AS) are a model of generalized tonic-clonic seizures." | 1.28 | Neuroethological evaluation of audiogenic seizures and audiogenic-like seizures induced by microinjection of bicuculline into the inferior colliculus. I. Effects of midcollicular knife cuts. ( Garcia-Cairasco, N; Oliveira, JA; Terra, VC; Tsutsui, J, 1992) |
| "However, when seizure was complicated by a preceding period of hypoxia, there was a marked and progressive rise in both excitatory and inhibitory amino acids in ECF." | 1.28 | Hypoxia increases extracellular concentrations of excitatory and inhibitory neurotransmitters in subsequently induced seizure: in vivo microdialysis study in the rabbit. ( Aquila, WJ; During, MJ; Ley, E; Tendler, D; Young, RS, 1992) |
| "In ethacrynic acid-induced convulsions, these neurotransmitter systems may be differentially modulated, probably through activation of glutaminergic neurons in the brain." | 1.28 | Ethacrynic acid-induced convulsions and brain neurotransmitters in mice. ( Hirose, T; Inagaki, C; Inoue, M; Yasukura, T, 1992) |
| "Limbic seizure-activity was induced by injecting kainic acid into the amygdala of rats." | 1.28 | Limbic seizure-induced changes in extracellular amino acid levels in the hippocampal formation: a microdialysis study of freely moving rats. ( Berg, M; Bruhn, T; Cobo, M; Diemer, NH, 1992) |
| "Tiagabine was administered in doses of 11." | 1.28 | The gamma-aminobutyric acid (GABA) uptake inhibitor, tiagabine, increases extracellular brain levels of GABA in awake rats. ( Fink-Jensen, A; Hansen, L; Judge, ME; Nielsen, PG; Suzdak, PD; Swedberg, MD, 1992) |
| "The effects of drugs on the convulsions induced by the combination of a new quinolone antimicrobial, enoxacin, and a nonsteroidal anti-inflammatory drug, fenbufen, were studied in mice." | 1.28 | [Effects of drugs on the convulsions induced by the combination of a new quinolone antimicrobial, enoxacin, and a nonsteroidal anti-inflammatory drug, fenbufen, in mice]. ( Ally, A; Hara, Y; Murayama, S; Suzuki, T, 1992) |
| "Immature rats are more susceptible to clonic seizures induced by aminooxyacetic acid (AOAA) than mature and senile rats." | 1.28 | Age dependency of the susceptibility of rats to aminooxyacetic acid seizures. ( Cavalheiro, EA; Dziki, M; Kleinrok, Z; Parada, J; Turski, W, 1992) |
| "Utilizing audiogenic seizure-prone P77PMC rats, the effects of cholecystokinin octapeptide (CCK-8) on genetic seizure susceptibility were studied in vivo, in cerebral cortical synaptosomes, and in cortical neuronal cell cultures." | 1.28 | Effects of cholecystokinin octapeptide on genetically determined seizure susceptibility. ( Lin, PX; Wu, XR, 1992) |
| "The evolution of seizures and postseizure inhibitions in the course of 'rapid kindling' and after the termination of stimulation were studied in rabbits with chronically implanted electrodes (neocortex, dorsal hippocampus, amygdala, caudate nucleus)." | 1.28 | Apparent disappearance of postseizure inhibitions and intensity of seizures during the development of rapid kindling in rabbits. ( Timofeeva, OA, 1992) |
| "Bicuculline treatment induced tonic/clonic seizures and status epilepticus in sham operated animals; these effects were drastically diminished at various time points after BCCA." | 1.28 | Transient reduction of cerebral blood flow leads to longlasting increase in GABA content in vulnerable structures and decreased susceptibility to bicuculline induced seizures. ( Block, F; Heim, C; Sieklucka, M; Sontag, KH, 1992) |
| "In other groups of rats seizures were elicited by i." | 1.28 | Transient reduction of cerebral blood flow leads to longlasting increase in GABA content in vulnerable structures and decreased susceptibility to bicuculline induced seizures. ( Block, F; Heim, C; Sieklucka, M; Sontag, KH, 1992) |
| "2." | 1.28 | Involvement of GABAergic mechanisms in chloroquine-induced seizures in mice. ( Amabeoku, G, 1992) |
| "motor seizures) as well as the development of kindling." | 1.28 | MK-801 prevents chemical kindling induced by pentylenetetrazol in rats. ( Corda, MG; Giorgi, O; Lecca, D; Orlandi, M, 1991) |
| "In fact, convulsions were not observed in rats pretreated with MK-801 either during the chronic PTZ administration or when challenged with PTZ three and 10 days after completion of the chronic treatment." | 1.28 | MK-801 prevents chemical kindling induced by pentylenetetrazol in rats. ( Corda, MG; Giorgi, O; Lecca, D; Orlandi, M, 1991) |
| "In addition, convulsive seizures evoked by the focal injection of bicuculline methiodide (40 ng) in an epileptogenic site within the deep prepiriform cortex (area tempestas) were not potentiated by intranigral isoniazid." | 1.28 | Lack of proconvulsant action of GABA depletion in substantia nigra in several seizure models. ( Gale, K; Maggio, R; Sohn, E, 1991) |
| "In a previous work, we have shown that seizures lead to an age-dependent upregulation of central benzodiazepine binding sites measured in isolated rat cerebral membranes." | 1.28 | Autoradiographic changes in central benzodiazepine binding sites and their coupling to gamma-aminobutyric acid receptors after seizures in the developing rat. ( Daval, JL; Werck, MC, 1991) |
| "Flumazenil did not produce any significant pharmacological effect." | 1.28 | In vivo bidirectional modulatory effect of benzodiazepine receptor ligands on GABAergic transmission evaluated by positron emission tomography in non-human primates. ( Bottlaender, M; Brouillet, E; Chavoix, C; Dodd, RH; Fournier, D; Hantraye, P; Khalili-Varasteh, M; Mazière, M, 1991) |
| "Paradoxically, GABA agonists increased seizure occurrence while GABA antagonists decreased seizure occurrence." | 1.28 | Paradoxical role of GABA in a chronic model of petit mal (absence)-like epilepsy in the rat. ( Bierkamper, GG; Smith, KA, 1990) |
| " Its anticonvulsant effects against 3-mercaptopropionic acid (MPA)-induced seizures in mice is related to the elevation of whole brain GABA concentrations: The mentioned doses of MDL 72483 which cause a decrease of GABA-T activity by 50%, produce within 5 h after dosing an increase of GABA concentration by about 3 mumol." | 1.28 | (4S)-4-amino-5,6-heptadienoic acid (MDL 72483): a potent anticonvulsant GABA-T inhibitor. ( Casara, P; Knödgen, B; Sarhan, S; Seiler, N, 1991) |
| "The incidences of both seizure and death for strychnine and death for picrotoxin were enhanced by treatment with GES, whereas the latency of pentetrazole-induced tonic extensor was prolonged." | 1.28 | [Drug-induced seizures in taurine-deficient mice]. ( Araki, H; Sano, M; Shimada, C; Tanaka, S, 1991) |
| "Tiagabine was an effective anticonvulsant in doses which did not produce sedation or motor debilitation, although it was not potent against MES." | 1.28 | Characterization of tiagabine (NO-328), a new potent and selective GABA uptake inhibitor. ( Andersen, KE; Braestrup, C; Knutsen, LJ; Nielsen, EB; Sonnewald, U; Suzdak, PD, 1991) |
| "However, lidocaine-induced convulsions were enhanced by AOAA." | 1.28 | Some correlations between local anesthetic-induced convulsions and gamma-aminobutyric acid in rat spinal cord. ( Kawaguchi, M; Ouchi, K; Sato, T; Sawaki, K, 1991) |
| "Gabapentin was administered at a dose of 23 mg/kg i." | 1.28 | Gabapentin increases aminooxyacetic acid-induced GABA accumulation in several regions of rat brain. ( Hönack, D; Löscher, W; Taylor, CP, 1991) |
| "(the ED95 against tonic electroconvulsions in rats) 1, 2 and 8 h prior to injection of AOAA, 100 mg/kg, i." | 1.28 | Gabapentin increases aminooxyacetic acid-induced GABA accumulation in several regions of rat brain. ( Hönack, D; Löscher, W; Taylor, CP, 1991) |
| "Rb1 mice were clonictonic seizure-prone, Rb2 mice were clonic seizure-prone and Rb3 mice were seizure resistant." | 1.28 | Amino acid neurotransmitter alterations in three sublines of Rb mice differing by their susceptibility to audiogenic seizures. ( Ciesielski, L; Clement, J; Mandel, P; Simler, S, 1990) |
| "At the onset of convulsions we found a 40-45% decrease in the K(+)-stimulated release of GABA." | 1.28 | Transmitter release in hippocampal slices from rats with limbic seizures produced by systemic administration of kainic acid. ( Arias, C; Montiel, T; Tapia, R, 1990) |
| "Protection against convulsions induced by cyanide was observed after treatment with alpha-ketoglutarate, either alone or in combination with sodium thiosulfate, a classical antagonist for cyanide intoxication." | 1.28 | Protection against cyanide-induced convulsions with alpha-ketoglutarate. ( Yamamoto, H, 1990) |
| "The ANT's were more susceptible to seizures induced by 3-mercaptopropionate (50 mg/kg, IP) than the AT's, suggesting the ANT's having greater sensitivity to a decrease in brain GABA concentration." | 1.28 | Plus-maze behavior and susceptibility to 3-mercaptopropionate-induced seizures in rat lines selected for high and low alcohol sensitivity. ( Hellevuo, K; Korpi, ER; Tuominen, K, 1990) |
| "These results show that the convulsions elicited by lindane can be facilitated by some GABA antagonists and antagonized by GABA mimetics, especially those that enhance GABA functionality." | 1.28 | GABAergic modulation of lindane (gamma-hexachlorocyclohexane)-induced seizures. ( Gelpí, E; Rodríguez-Farré, E; Suñol, C; Tusell, JM, 1989) |
| "The antiseizure activity of the glia-selective GABA uptake inhibitor, 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-c]azepin-3-ol (THAO), was evaluated in rats in models of acute chemoconvulsion." | 1.28 | Anticonvulsant activity of the glial GABA uptake inhibitor, THAO, in chemical seizures. ( Gonsalves, SF; Harbaugh, RE; Krogsgaard-Larsen, P; Schousboe, A; Twitchell, B, 1989) |
| "Kainic acid treatment resulted in a significant reduction of choline acetyltransferase activity in the piriform cortex (by 20%), amygdala (by 19%), and nucleus basalis (by 31%) in comparison with vehicle-injected control rats." | 1.28 | Changes in cholinergic but not in GABAergic markers in amygdala, piriform cortex, and nucleus basalis of the rat brain following systemic administration of kainic acid. ( Rothe, T; Schliebs, R; Steinbach, J; Zivin, M, 1989) |
| "2." | 1.28 | Cerebrospinal fluid GABA and seizure control with vigabatrin. ( Halonen, T; Pitkanen, A; Riekkinen, PJ; Sivenius, J; Ylinen, A, 1989) |
| " Acute and long-term haloperidol administration induced significant leftward displacement of the control dose-response curves for picrotoxin but not those for strychnine or 3-mercaptopropionic acid (3-MPA)." | 1.28 | Behavioral aspects of GABAergic-dopaminergic interactions in the central nervous system. ( Palermo-Neto, J; Sandoval, MR, 1989) |
| "In animals that presented convulsion a stereotyped gnawing and/or licking behavior was observed immediately after the ictus activity as a consequence of the combined acute administration of haloperidol and picrotoxin." | 1.28 | Behavioral aspects of GABAergic-dopaminergic interactions in the central nervous system. ( Palermo-Neto, J; Sandoval, MR, 1989) |
| "4." | 1.28 | Evidence that repetitive seizures in the hippocampus cause a lasting reduction of GABAergic inhibition. ( Kapur, J; Lothman, EW; Stringer, JL, 1989) |
| "In kindled rats, 31 days after the last seizure, the number of GABA-immunoreactive cells that could be observed after AOAA-treatment was significantly lower (35% ipsilateral and 25% contralateral) when compared to AOAA-treated controls." | 1.28 | Decrease in GABA immunoreactivity and alteration of GABA metabolism after kindling in the rat hippocampus. ( Huisman, E; Kamphuis, W; Lopes da Silva, FH; Wadman, WJ, 1989) |
| "Like 1 and 2, tonic-clonic seizures were induced when trans-3 or -4 were administered to mice intracerebroventricularly." | 1.27 | Stereoselective syntheses of the trans-decahydroquinoline-5-carboxylic acid epimers. Diastereomeric zwitterionic probes of gamma-aminobutyric acid related biological properties in vitro and in vivo. ( Enna, SJ; Fung, YK; Patch, RJ; Witiak, DT, 1986) |
| "Progabide has been shown to be effective in various forms of epilepsy in double-blind and long-term clinical trials." | 1.27 | Pharmacology of the GABAergic system: effects of progabide, a GABA receptor agonist. ( Bartholini, G, 1984) |
| "Their convulsion properties are apparently related to the specific levels, locations and convulsive potential of the individual substances." | 1.27 | [Neuroendocrinologic aspects of epilepsy]. ( Bergamasco, B; Bianco, C; Cavallo, G; Pinessi, L, 1984) |
| "Glycine content was reduced preictally only in the substantia nigra; after seizure onset its concentration rose in all brain areas." | 1.27 | Alterations in the content of amino acid neurotransmitters before the onset and during the course of methoxypyridoxine-induced seizures in individual rabbit brain regions. ( Haug, P; Nitsch, C; Schmude, B, 1983) |
| "In rabbits, generalized seizures were induced by methoxypyridoxine, and changes in amino acid concentrations of 15 brain regions were investigated before seizure onset and during the course of sustained epileptiform activity." | 1.27 | Alterations in the content of amino acid neurotransmitters before the onset and during the course of methoxypyridoxine-induced seizures in individual rabbit brain regions. ( Haug, P; Nitsch, C; Schmude, B, 1983) |
| "Ro 15-1788 completely blocked type B myoclonus without decreasing the level of vigilance in the two types of baboons, and reversed the antiepileptic action of the BZs in the photosensitive ones, permitting the reappearance of myoclonus following EEG paroxysmal discharges (type A)." | 1.27 | Differential effects of the benzodiazepine antagonist Ro 15-1788 on two types of myoclonus in baboon Papio papio. ( Bryere, P; Kaijima, M; Naquet, R; Valin, A, 1983) |
| "L-Allylglycine seizures are associated with generalized decreases in GABA concentrations (-32 to -54%), increases in glutamine concentrations (+10 to +53%), and a decrease in cortical aspartate concentration (-14%)." | 1.27 | Changes in regional neurotransmitter amino acid levels in rat brain during seizures induced by L-allylglycine, bicuculline, and kainic acid. ( Chapman, AG; Meldrum, BS; Premachandra, M; Westerberg, E, 1984) |
| "In audiogenic seizure-susceptible (AGS) mice, evidence suggests a role for dopamine as well as GABA and possibly serotonin." | 1.27 | Neurotransmitter abnormalities in genetically epileptic rodents. ( Dailey, JW; Jobe, PC; Laird, HE, 1984) |
| "These findings show that convulsions elicited by lindane are not due to an impairment of the GABAergic system." | 1.27 | Convulsions induced by lindane and the involvement of the GABAergic system. ( Cattabeni, F; Eli, M; Pastorello, MC, 1983) |
| "The seizures were not affected by the drugs in doses under study." | 1.27 | [Convulsions induced by kynurenine and quinolinic acid as a sensitive test for assessing the anticonvulsant activity of GABA-ergic preparations]. ( Lapin, IP; Ryzhov, IV, 1983) |
| "Repeated kindled seizures result in increased numbers of benzodiazepine receptors in fascia dentata membranes." | 1.27 | Kindled seizures result in decreased responsiveness of benzodiazepine receptors to gamma-aminobutyric acid (GABA). ( Fanelli, RJ; McNamara, JO, 1983) |
| "The bicuculline induced convulsions were markedly potentiated during the first hour but completely blocked from 2-6 h after AOAA." | 1.27 | Aminooxyacetic acid induced accumulation of GABA in the rat brain. Interaction with GABA receptors and distribution in compartments. ( Gomes, C; Leite, JR; Pagliusi, SR; Trolin, G, 1983) |
| "This diazepam-elicited increase in Bmax is blocked in mice receiving the diazepam antagonist Ro 15-1788 (ethyl-8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5a]-[1,4] benzodiazepine-3-carboxylate)." | 1.27 | Increase in the Bmax of gamma-aminobutyric acid-A recognition sites in brain regions of mice receiving diazepam. ( Costa, E; Ferrero, P; Guidotti, A, 1984) |
| "Though the convulsions looked similar to morphine-induced seizures, naloxone failed to antagonize these effects." | 1.27 | Possible mechanism of digoxin-induced convulsions. ( Kulkarni, SK; Mehta, AK, 1983) |
| "Valproic acid was included as a reference standard." | 1.27 | High anticonvulsant potency of gamma-aminobutyric acid (GABA)mimetic drugs in gerbils with genetically determined epilepsy. ( Frey, HH; Löscher, W; Reiche, R; Schultz, D, 1983) |
| "The onset of convulsions and mortality due to PTX were significantly delayed." | 1.27 | Facilitation of diazepam action by anticonvulsant agents against picrotoxin induced convulsions. ( Jog, MV; Kulkarni, SK, 1983) |
| "After repeated seizures (twice a day for 15 days), induced by an acoustic stimulus in Swiss Rb1 Mice selected for audiogenic seizures, this correlation is no longer observed." | 1.27 | [Demonstration of the correlation of the degree of synthesis and 4-aminobutyric acid levels in the central nervous system; effect of repeated convulsive seizures]. ( Ciesielski, L; Clément, J; Mandel, P; Schreiber, R; Simler, S, 1984) |
| "To clarify the biochemical mechanism of convulsions from a view point of the amino acid metabolism, the free amino acid patterns in brains of El mice were investigated." | 1.27 | Amino acid metabolism in the brain with convulsive disorders. Part I: Free amino acid patterns in the brain of E1 mouse with convulsive seizure. ( Honda, T, 1984) |
| "In chemically elicited seizures in mice, CM 40142 exhibited a higher potency than sodium valproate in antagonizing anti-GABAergic agents." | 1.27 | Anticonvulsant activity of 4,9-dioxo-5,10-diazatetradecane (CM 40142), a new GABA derivative, in mice and photosensitive baboons). ( Bizière, K; Calassi, R; Chambon, JP; Leyris, R; Maruani, J; Molimard, JC; Rodier, D; Roncucci, R; Sigault, G, 1984) |
| "Its ED50 on cardiazol -induced convulsions is 60-65 mg/kg." | 1.27 | An N-protected gamma-aminobutyric acid dipeptide with anticonvulsant action. ( Barthez, A; Bertazzon, A; Bianchi, M; Coletti-Previero, MA; Galzigna, L; Quadro, G, 1984) |
| "A study of the effects of MNPC on convulsions induced by chemicals which interfere with GABA-mediated neurotransmission was carried out in the mouse, with MNPC being administered by subcutaneous injection 30, 60 or 90 min prior to challenge with bicuculline." | 1.27 | Anticonvulsant activity of the nipecotic acid ester, (+/-)-m-nitrophenyl-3-piperidinecarboxylate. ( Crider, AM; Hinko, CN; Seibert, K, 1984) |
| "Milacemide has a low toxicity (LD50: 2585 mg/kg in the mouse) and alters the behaviour of mouse, rat and monkey, only at high doses (greater than or equal to 1000 mg/kg)." | 1.27 | Anticonvulsant activity of milacemide. ( Barris, D; Cordi, A; Roba, J; van Dorsser, W, 1983) |
| "SK&F 100330A also inhibited MES convulsions in rats." | 1.27 | Novel inhibitors of gamma-aminobutyric acid (GABA) uptake: anticonvulsant actions in rats and mice. ( Fowler, PJ; Setler, PE; Yunger, LM; Zarevics, P, 1984) |
| "The age related audiogenic seizure susceptibility of DBA/2 mice is not related to an abnormality of neuronal GABA uptake." | 1.27 | Synaptosomal [3H]GABA uptake and [3H]nipecotic acid binding in audiogenic seizure susceptible (DBA/2) and resistant (C57 B1/6) mice. ( Horton, RW; Prestwich, SA; Spyrou, NA, 1984) |
| "Pyridoxine-dependent seizures occur as a result of an increased requirement of the vitamin within the central nervous system." | 1.27 | Pyridoxine-dependent seizures. ( Crowell, GF; Roach, ES, 1983) |
| "Cortical seizures (measured by ECoG activity) and spontaneous trochlear motoneuron bursting occurred at bicuculline doses which reduced inhibitory vestibular-trochlear field potentials by 10% or less." | 1.27 | Reduction of postsynaptic inhibition tolerated before seizure initiation: brain stem. ( Crill, WE; Schwindt, PC; Tribble, GL, 1983) |
| "Sound-induced seizures are suppressed by the i." | 1.27 | Anticonvulsant activity of GABA uptake inhibitors and their prodrugs following central or systemic administration. ( Croucher, MJ; Krogsgaard-Larsen, P; Meldrum, BS, 1983) |
| "During 1 h of bicuculline-induced seizures (1." | 1.27 | Cortical GABA turnover during bicuculline seizures in rats. ( Chapman, AG; Evans, MC, 1983) |
| "However, ethosuximide must act against generalized absence seizures and against pentylenetetrazol-induced seizures by a third, as yet unknown, mechanism." | 1.27 | Anticonvulsant drug mechanisms of action. ( Macdonald, RL; McLean, MJ; Skerritt, JH, 1985) |
| "All animals suffered tonic convulsions at 18." | 1.27 | Convulsant effect of lindane and regional brain concentration of GABA and dopamine. ( Gelpí, E; Rodríguez-Farré, E; Suñol, C; Tusell, JM, 1988) |
| "Convulsive seizures are a potential side effect of antidepressant drug treatment and can be produced by all classes of antidepressants." | 1.27 | Antidepressants and seizure-interactions at the GABA-receptor chloride-ionophore complex. ( Ikeda, M; Knapp, RJ; Malatynska, E; Yamamura, HI, 1988) |
| "The biochemical and behavioural effects of the chronic administration of the beta-carboline inverse agonist FG 7142 were studied in the rat." | 1.27 | Enhanced sensitivity to beta-carboline inverse agonists in rats chronically treated with FG 7142. ( Biggio, G; Corda, MG; Giorgi, O; Mele, S, 1987) |
| "Thus, myoclonic seizures were observed in 30% and 80% of the animals by the third and the eighth day of treatment, respectively." | 1.27 | Enhanced sensitivity to beta-carboline inverse agonists in rats chronically treated with FG 7142. ( Biggio, G; Corda, MG; Giorgi, O; Mele, S, 1987) |
| "Clonic seizures were induced in Swiss or DBA/2 mice by methyl-6-7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM), 0." | 1.27 | Effects of two convulsant beta-carboline derivatives, DMCM and beta-CCM, on regional neurotransmitter amino acid levels and on in vitro D-[3H]aspartate release in rodents. ( Chapman, AG; Cheetham, SC; Hart, GP; Meldrum, BS; Westerberg, E, 1985) |
| "Kindled seizures were almost completely blocked by treatment with carbamazepine, whereas the effect of valproic acid was partial, suppressing only generalized seizures." | 1.27 | Effects of carbamazepine and valproic acid on brain immunoreactive somatostatin and gamma-aminobutyric acid in amygdaloid-kindled rats. ( Higuchi, T; Igarashi, Y; Kato, N; Minatogawa, Y; Nagaki, S; Ohshima, H; Takazawa, A; Watanabe, N; Yamazaki, J; Yamazaki, O, 1986) |
| "Using a model in which seizure activity was elicited electrically from the inferior colliculus, the influence of both inhibitory and excitatory putative neurotransmitter amino acids on this seizure activity was assessed by manipulating neurotransmitter amino acid function." | 1.27 | Amino acid influences on seizures elicited within the inferior colliculus. ( Breese, GR; Givens, BS; McCown, TJ, 1987) |
| "It also prevented pentylenetetrazol seizures in rats in a four times lower dose." | 1.27 | Antagonism of seizures induced by the administration of the endogenous convulsant quinolinic acid into rat brain ventricles. ( Kiseleva, IP; Lapin, IP; Prakhie, IB, 1986) |
| "Seizures were more sensitive to the drug than tremors." | 1.27 | Suppression by progabide of ethanol withdrawal syndrome in rats. ( Fadda, F; Gessa, GL; Meloni, R; Mosca, E, 1985) |
| "Muscimol and gaboxadol were almost inactive in attenuating kindled seizures even at doses that produced pronounced side effects." | 1.27 | Evaluation of different GABA receptor agonists in the kindled amygdala seizure model in rats. ( Löscher, W; Schwark, WS, 1985) |
| "A decrease in severity of motor seizures was found only after 200 mg/kg progabide which, however, gave rise to marked sedation and muscle relaxation." | 1.27 | Evaluation of different GABA receptor agonists in the kindled amygdala seizure model in rats. ( Löscher, W; Schwark, WS, 1985) |
| "Pipecolic acid (PA) is an alicyclic amino acid and putative neurotransmitter which may modulate GABAergic transmission in the central nervous system." | 1.27 | Inhibition of intrathecally administered picrotoxin- and bicuculline-induced convulsions in mice by pipecolic acid or GABA. ( Beitz, AJ; Larson, AA, 1985) |
| "significantly increased seizure protection and seizure latency (the time required to develop seizures after PTZ injection) with a peak effect dose at 10 mmol/kg." | 1.27 | Effects of L-lysine and its metabolites on pentylenetetrazol-induced seizures. ( Chang, YF; Myslinski, NR, 1985) |
| "RO5-4864-induced convulsions were blocked by diazepam, clonazepam, pentobarbital, ethanol and amino-oxyacetic acid (AOAA)." | 1.27 | A possible role of a GABAergic mechanism in the convulsant action of RO5-4864. ( Rastogi, SK; Ticku, MK, 1985) |
| " THIP, even at toxic doses, did not alter the anti-PTZ activity of either pentobarbital or phenobarbital." | 1.27 | Effects of gamma-aminobutyric acid (GABA) receptor agonists on the neurotoxicity and anticonvulsant activity of barbiturates in mice. ( Chweh, AY; Swinyard, EA; Ulloque, RA, 1986) |
| "The acute administration of an anticonvulsant dose of ethosuximide (150 mg/kg) had no effect on brain gamma-aminobutyric acid (GABA) concentration, whereas a toxic dose (400 mg/kg) increased significantly the concentration of brain GABA (1." | 1.27 | Effect of ethosuximide alone and in combination with gamma-aminobutyric acid receptor agonists on brain gamma-aminobutyric acid concentration, anticonvulsant activity and neurotoxicity in mice. ( Chweh, AY; Lin-Michell, E; Swinyard, EA, 1986) |
| " These results imply that the tolerance that develops in response to the chronic administration of toxic doses of ethosuximide correlates well with the concentration of brain GABA." | 1.27 | Effect of ethosuximide alone and in combination with gamma-aminobutyric acid receptor agonists on brain gamma-aminobutyric acid concentration, anticonvulsant activity and neurotoxicity in mice. ( Chweh, AY; Lin-Michell, E; Swinyard, EA, 1986) |
| "Pentobarbital and diazepam were effective against both tonic and clonic seizure components induced by bicuculline and picrotoxin." | 1.27 | Anticonvulsant profile of drugs which facilitate GABAergic transmission on convulsions mediated by a GABAergic mechanism. ( Rastogi, SK; Ticku, MK, 1986) |
| "Thus, seizures induced by bicuculline were more sensitive to the inhibition by pentobarbital in combination with diazepam or ethanol, while pentobarbital with progabide was equally effective against convulsions induced by GABA antagonists." | 1.27 | Anticonvulsant profile of drugs which facilitate GABAergic transmission on convulsions mediated by a GABAergic mechanism. ( Rastogi, SK; Ticku, MK, 1986) |
| "Sensitivity to flurothyl-induced seizures was also strain dependent, but the rank order of sensitivity was different than for MP." | 1.27 | Genetic influences on GABA-related seizures. ( Gaffney, D; Marley, RJ; Wehner, JM, 1986) |
| "Thus, the seizure-facilitating nigral efferents may be subject to inhibition by both GABA and opiates and may normally be driven by substance P." | 1.27 | Role of the substantia nigra in GABA-mediated anticonvulsant actions. ( Gale, K, 1986) |
| " The enhancement of punishment suppressed behaviour, the sensitization to isoniazid-induced convulsions and the decrease in the density of low-affinity GABA receptors suggest that chronic administration of FG 7142 induces a persistent down-regulation of GABAergic transmission in the central nervous system." | 1.27 | Behavioural and biochemical evidence for a long-lasting decrease in GABAergic function elicited by chronic administration of FG 7142. ( Biggio, G; Corda, MG; Giorgi, O, 1986) |
| "A significant sensitization to seizures induced by isoniazid, a drug known to inhibit GABAergic transmission, was also found to occur after long-term (25 days) withdrawal." | 1.27 | Behavioural and biochemical evidence for a long-lasting decrease in GABAergic function elicited by chronic administration of FG 7142. ( Biggio, G; Corda, MG; Giorgi, O, 1986) |
| "Fengabine (SL 79." | 1.27 | Fengabine, a novel antidepressant GABAergic agent. I. Activity in models for antidepressant drugs and psychopharmacological profile. ( Bartholini, G; Depoortere, H; Lloyd, KG; Sanger, D; Zivkovic, B, 1987) |
| "The relationship of seizure susceptibility to alterations in the GABA receptor complex was investigated in six different populations of mice consisting of four inbred strains (C57BL, DBA, C3H, and BALB) and two selected lines (long sleep and short sleep)." | 1.27 | Correlation between the enhancement of flunitrazepam binding by GABA and seizure susceptibility in mice. ( Marley, RJ; Wehner, JM, 1987) |
| "Withdrawal seizure prone (WSP) and withdrawal seizure resistant (WSR) lines of mice have been genetically selected based on the severity of handling-induced convulsions after identical chronic ethanol exposure." | 1.27 | Differences in GABA activity between ethanol withdrawal seizure prone and resistant mice. ( Crabbe, JC; Feller, DJ; Harris, RA, 1988) |
| "Latencies to seizure onset and tonus after intraperitoneal (IP) injections of MP (25-40 mg/kg) were quantified." | 1.27 | Classical genetic analysis of GABA-related seizures. ( Marley, RJ; Martin, BJ; Miner, LL; Wehner, JM, 1988) |
| "The incidence and severity of convulsions were monitored in individual rats until they were sacrificed by focused microwave irradiation of the head at the following time points after soman administration: 4 min, a time prior to the onset of convulsions; 10 min, the time of onset of convulsions; 1 h, the time of peak convulsive activity; and 6 h, a time at which rats were recovering from convulsions." | 1.27 | Evidence that alterations in gamma-aminobutyric acid and acetylcholine in rat striata and cerebella are not related to soman-induced convulsions. ( Ho, IK; Hoskins, B; Liu, DD; Ueno, E, 1988) |
| "GVG showed no selectivity for seizures produced by impairment of GABA-ergic neurotransmission." | 1.27 | Gamma-vinyl GABA: comparison of neurochemical and anticonvulsant effects in mice. ( Bernasconi, R; Christen, P; Hafner, T; Klein, M; Martin, P; Portet, C; Schmutz, M, 1988) |
| "In an infant with neonatal seizures, CSF GABA levels were determined before and after treatment with vitamin B6." | 1.27 | Disappearance of neonatal seizures and low CSF GABA levels after treatment with vitamin B6. ( Dominick, HC; Kurlemann, G; Löscher, W; Palm, GD, 1987) |
| "Mice treated with manganese chloride (MnCl2) showed increases in brain manganese comparable to those of the mice showing seizure activity due to MMT, but exhibited no sign of seizure activity." | 1.27 | Neurotoxic effects of methylcyclopentadienyl manganese tricarbonyl (MMT) in the mouse: basis of MMT-induced seizure activity. ( Fishman, BE; Gianutsos, G; McGinley, PA, 1987) |
| " The LD50 associated with seizure activity was lower in mice receiving MMT in propylene glycol (152 mg/kg) than in those receiving MMT in corn oil (999 mg/kg)." | 1.27 | Neurotoxic effects of methylcyclopentadienyl manganese tricarbonyl (MMT) in the mouse: basis of MMT-induced seizure activity. ( Fishman, BE; Gianutsos, G; McGinley, PA, 1987) |
| "One neurotoxic effect of MMT in mice is seizure activity." | 1.27 | Neurotoxic effects of methylcyclopentadienyl manganese tricarbonyl (MMT) in the mouse: basis of MMT-induced seizure activity. ( Fishman, BE; Gianutsos, G; McGinley, PA, 1987) |
| "After determination of a stable seizure triggering threshold, the rats were implanted with osmotic minipumps (1 microliter/h for 7 days) connected to previously implanted bilateral cannulae." | 1.27 | Anticonvulsant effect of intracortical, chronic infusion of GABA in kindled rats: focal seizures upon withdrawal. ( Brailowsky, S; Fukuda, H; Ménini, C; Naquet, R; Riche, D; Silva-Barrat, C, 1987) |
| "5 It is proposed that a convulsion results in an inhibition of GABA release and that this inhibition may in turn inhibit GABA synthesis as described in the preceding paper." | 1.27 | Inhibition of GABA release from slices prepared from several brain regions of rats at various times following a convulsion. ( Green, AR; Minchin, MC; Vincent, ND, 1987) |
| "However, 30 min after the last convulsion, K+-evoked GABA release above basal release was inhibited in both hippocampus (20%) and striatum (33%) but not in the cortex." | 1.27 | The effect of repeated electroconvulsive shock on GABA synthesis and release in regions of rat brain. ( Green, AR; Vincent, ND, 1987) |
| "3 Five min after seizure induced by the inhalant convulsant flurothyl there was no rise in GABA content in these brain regions but a similar marked degree of inhibition of GABA synthesis." | 1.27 | Inhibition of the rate of GABA synthesis in regions of rat brain following a convulsion. ( Green, AR; Metz, A; Minchin, MC; Vincent, ND, 1987) |
| " Bilateral nigral infusions of muscimol markedly facilitated the development of flurothyl seizures in a dose-response manner and differed significantly from the vehicle controls or rats infused with muscimol dorsally to the substantia nigra." | 1.27 | Age-related substantia nigra-mediated seizure facilitation. ( Moshe, SL; Okada, R; Sperber, EF; Wong, BY; Zhao, DY, 1986) |
| "At age 16 to 17 days, seizures were induced in the cannulated rats and naive (intact) controls by exposure to flurothyl following pretreatment with the GABA agonist, muscimol, or vehicle." | 1.27 | Age-related substantia nigra-mediated seizure facilitation. ( Moshe, SL; Okada, R; Sperber, EF; Wong, BY; Zhao, DY, 1986) |
| "Seizures were induced in a variety of inbred strains of mice including C57BL, C3H, DBA mice and in a heterogeneous stock of mice." | 1.27 | Genetic differences in the effects of delta-aminolevulinic acid on seizure latency in mice. ( Marley, RJ; Wehner, JM, 1986) |
| "injections also delayed clonic seizures induced by flurothyl, and increased the latency to tonic seizures induced by 3-mercaptopropionic acid." | 1.27 | Genetic differences in the effects of delta-aminolevulinic acid on seizure latency in mice. ( Marley, RJ; Wehner, JM, 1986) |
| " Observation of behaviour indicated that the novel GABA uptake blockers exerted no side-effects in anticonvulsant doses, whereas diazepam produced sedative effects at all active dosage levels." | 1.27 | Comparison of the anticonvulsant effects of two novel GABA uptake inhibitors and diazepam in amygdaloid kindled rats. ( Löscher, W; Schwark, WS, 1985) |
| "they inhibited seizure severity, increased seizure latency, and decreased the duration of motor seizures and EEG after discharges." | 1.27 | Comparison of the anticonvulsant effects of two novel GABA uptake inhibitors and diazepam in amygdaloid kindled rats. ( Löscher, W; Schwark, WS, 1985) |
| "The latency to clonic convulsion was dramatically affected by prior shock treatment, and the direction of this change depended upon the escapability/inescapability of the shock." | 1.27 | Coping and seizure susceptibility: control over shock protects against bicuculline-induced seizures. ( Alpern, HP; Drugan, RC; Maier, SF; McIntyre, TD, 1985) |
| " Cetyl GABA failed to show a linear dose-response against minor seizures but was quite potent against major ones (ED 50 4." | 1.27 | Anticonvulsant action of GABA agonists and prodrugs on minor and major seizures in epileptic gerbils. Comparison with mouse models of seizure states. ( Löscher, W, 1985) |
| "pentylenetetrazol-induced seizures in mice." | 1.27 | Anticonvulsant action of GABA agonists and prodrugs on minor and major seizures in epileptic gerbils. Comparison with mouse models of seizure states. ( Löscher, W, 1985) |
| "The onset of generalized seizures induced by isoniazid (800 mg/kg) or by thiosemicarbazide (64 mg/kg) i." | 1.26 | Decreased convulsant potency of picrotoxin and pentetrazol and enhanced [3H]flunitrazepam cortical binding following stressful manipulations in rats. ( Hamon, M; Hery, F; Jobert, A; Montastruc, JL; Soubrie, P; Thiebot, MH, 1980) |
| "Like seizure susceptibility, the differences in benzodiazepine binding were age-related." | 1.26 | Audiogenic seizures: increased benzodiazepin receptor binding in a susceptible strain of mice. ( Robertson, HA, 1980) |
| "Moreover, harmane-induced convulsions can be inhibited reversibly by diazepam in a manner which is consistent with the assumption of competitive antagonism in vivo." | 1.26 | Benzodiazepine antagonism by harmane and other beta-carbolines in vitro and in vivo. ( Borbe, HO; Fehske, KJ; Müller, WE; Nanz, C; Rommelspacher, H; Wollert, U, 1981) |
| "In mice, running, clonic and tonic convulsions and lethality were assessed following transcorneal (electroshock) current or convulsant drugs, each administered alone and after cannabidiol (CBD) pretreatment." | 1.26 | Effects of cannabidiol on behavioral seizures caused by convulsant drugs or current in mice. ( Benedito, MA; Carlini, EA; Consroe, P; Leite, JR; Mechoulam, R, 1982) |
| "The antiseizure effects of nicotinamide depended on the time of its injection." | 1.26 | [Effect of pantogam, nicotinamide, and phenazepam on seizure activity]. ( Godlevskiĭ, LS; Kryzhanovskiĭ, GN; Nikushkin, EV; Shandra, AA, 1982) |
| " It means that over this dosage range haloperidol potentiates GABA-induced effects." | 1.26 | [Participation of GABA-ergic structures in producing the effects of haloperidol]. ( Molodavkin, GM; Ostrovskaia, RU, 1980) |
| "Myoclonic seizures of the hindlegs are induced in mice by l- and d,l-kynurenine." | 1.26 | Kynurenines and seizures. ( Lapin, IP, 1981) |
| "Alcoholics without seizures had higher GABA levels than either alcoholics with seizures or controls." | 1.26 | Cerebrospinal fluid GABA and cyclic nucleotides in alcoholics with and without seizures. ( Gold, BI; Goldman, GD; Roth, RH; Volicer, L, 1981) |
| "Electroconvulsive seizures administered during the period of fetal benzodiazepine (BZ) binding site proliferation (days 16, 18 and 20 in gestation) significantly decreased the density of cerebral cortical benzodiazepine binding sites in exposed pups up to 21 days postnatal age." | 1.26 | Prenatal exposure to electroconvulsive seizures and phenytoin: development of benzodiazepine binding sites, reflex behaviors and seizure thresholds in exposed offspring. ( Gallager, DW; Wakeman, EA, 1982) |
| "The onset of clonic seizures induced by 3-mercaptopropionic acid (MP) was associated with an approximately 200% increase of cAMP and a 70% elevation of cGMP in the mouse cerebral cortex." | 1.26 | Cyclic GMP and cyclic AMP in the cerebral cortex of mice during seizures induced by 3-mercaptopropionic acid: effects of anticonvulsant agents. ( Folbergrová, J, 1980) |
| "When MP convulsions were prevented by Na-phenobarbital, the levels of both nucleotides were not different from control concentrations." | 1.26 | Cyclic GMP and cyclic AMP in the cerebral cortex of mice during seizures induced by 3-mercaptopropionic acid: effects of anticonvulsant agents. ( Folbergrová, J, 1980) |
| "No protection against seizures was seen after THIP, 1-4 mg/kg, intraperitoneally in mice." | 1.26 | Effects of the bicyclic GABA agonist, THIP, on myoclonic and seizure responses in mice and baboons with reflex epilepsy. ( Horton, R; Meldrum, B, 1980) |
| "Homotaurine is a powerful GABA agonist that exerts a central action upon parenteral administration." | 1.26 | Activating effects of homotaurine and taurine on corticoreticular epilepsy. ( Black, JA; Fariello, RG; Golden, GT, 1981) |
| "A residual effect of DPA against seizures induced by pentetrazole was shown, i." | 1.26 | Anticonvulsant and antiaggressive properties of di-n-propyl acetate after repeated treatment. ( Ciesielski, L; Klein, M; Mandel, P; Simler, S, 1982) |
| "Afterdischarge duration, motor seizure latency, motor seizure duration and motor seizure stage were scored." | 1.26 | Pharmacological investigation of gamma-aminobutyric acid (GABA) and fully-developed generalized seizures in the amygdala-kindled rat. ( Burnham, WM; Kalichman, MW; Livingston, KE, 1982) |
| "The potentiation of picrotoxin convulsions was correlated with the pattern of kindling development but not with the number of stimulations or seizures." | 1.26 | Pharmacological investigation of convulsant gamma-aminobutyric acid (GABA) antagonists in amygdala-kindled rats. ( Kalichman, MW, 1982) |
| "In this study the pentetrazole seizure threshold of dogs was compared with the concentration of GABA in the CSF and blood plasma." | 1.26 | Relationship between GABA concentrations in cerebrospinal fluid and seizure excitability. ( Löscher, W, 1982) |
| "Pentylenetetrazole was administered to Swiss-Albino mice, producing clonic-tonic seizures." | 1.26 | Pentylenetetrazole induced changes in cerebellar energy metabolism. ( McCandless, DM; Schwartzenburg, FC, 1982) |
| "Mice were sacrificed during the preseizure (1 minute) stage and at the onset of clonic-tonic seizures (2 minutes)." | 1.26 | Pentylenetetrazole induced changes in cerebellar energy metabolism. ( McCandless, DM; Schwartzenburg, FC, 1982) |
| "Blockade of tonic and clonic seizures was also obtained after microinjections of the direct GABA receptor agonist, muscimol, into the midbrain." | 1.26 | Substantia nigra: site of anticonvulsant activity mediated by gamma-aminobutyric acid. ( Gale, K; Iadarola, MJ, 1982) |
| "Prominal reduced the severity of convulsions in pp'DDT-treated animals." | 1.26 | A possible neurochemical basis of the central stimulatory effects of pp'DDT. ( Jaffery, FN; Matin, MA; Siddiqui, RA, 1981) |
| "Repeated audiogenic seizures (4 times a day for 14 days), in genetically selected sensitive mice, induce a significant decrease in GABA level in the following brain areas: nucleus caudatus, posterior colliculus, occipital and frontal cortex, cerebellum, substantia nigra, hippocampus, amygdala, and temporal cortex." | 1.26 | Effect of repeated convulsive seizures on brain GABA levels. ( Ciesielski, L; Mandel, P; Simler, S, 1981) |
| "Behavioral seizures reappeared 2 to 3 days after termination of GAG treatment." | 1.26 | Amygdaloid kindling and the GABA system. ( Myslobodsky, MS; Valenstein, ES, 1980) |
| "The antagonism of various seizure and time-related components of the convulsions resulting after IV injection of D,L-allylglycine into male Wistar rats were assessed in a standard test procedure." | 1.26 | Effects of some anti-epileptic, neuroleptic and gabaminergic drugs on convulsions induced by D,L-allylglycine. ( Ashton, D; Wauquier, A, 1979) |
| "Penicillin seizures do not cause a change in levels of GABA, but result in a decrease in glutamate within the focus." | 1.26 | Effect of amino-oxyacetic acid (AOAA) on focal penicillin seizures. ( Collins, RC; Mehta, S, 1978) |
| "Gamma-Aminobutyric acid (GABA) has been implicated in the neurochemistry of epilepsy." | 1.26 | Low cerebrospinal fluid gamma-aminobutyric acid content in seizure patients. ( Ballenger, JC; Glaeser, BS; Hare, TA; Post, RM; Wood, JH, 1979) |
| "Although lumbar CSF GABA levels in our seizure patients did not significantly correlate with serum concentrations of phenytoin, phenobarbital, or primidone, additional study of medication-free epileptic patients may be required to evaluate the possibility of anticonvulsant-drug-induced CSF GABA alterations." | 1.26 | Low cerebrospinal fluid gamma-aminobutyric acid content in seizure patients. ( Ballenger, JC; Glaeser, BS; Hare, TA; Post, RM; Wood, JH, 1979) |
| "Phenytoin was less potent than apomorphine with GHBA or apomorphine given together with AOAA." | 1.26 | Effect of combined dopaminergic and GABA-ergic stimulation on ouabain-induced epileptiform activity. ( Kacz, D; Stach, R, 1977) |
| "Rats exposed to chronic intake of sodium barbital maintained high circulating levels of barbital in blood and brain and exhibited increased sensitivity ot audiogenic convulsions during the withdrawal period." | 1.26 | Changes in brain levels of cyclic nucleotides and gamma-aminobutyric acid in barbiturate dependence and withdrawal. ( Hawkins, TD; Kant, GJ; Lenox, RH; Meyerhoff, JL; Wray, HL, 1979) |
| "The hypothesis that the seizure susceptibility of chronically denervated cortex is due to interruption of recurrent inhibitory pathways was tested by examining the release of 3H-labeled gamma-aminobutyric acid ([3H]GABA) from chronic slabs and normal cortex of cats." | 1.26 | Release of exogenous gamma-[3H]aminobutyric acid during seizure activity in chronically denervated and normal cat cortex. ( Reiffenstein, RJ, 1979) |
| "When the convulsions were protected by pretreatment with AOAA, the decreased GABA releases in both the conditions rose to or above the normal levels." | 1.26 | Release of gamma-aminobutyric acid from isolated brain synaptosomes during semicarbazide-induced convulsions. ( Asakura, T; Hoshino, M; Matsuda, M, 1979) |
| "The onset of convulsions induced by these convulsants coincides with the fall in GABA content and GAD activity in the mesencephalon area, and in contrast, the cessation of the convulsions by PN supplement coincides with the recovery in both the parameters." | 1.26 | Effect of antivitamin B6 on regional GABA metabolism in mouse brain and its relation to convulsions. ( Abe, M; Matsuda, M, 1979) |
| "naloxone in high doses caused convulsions in mice, and potentiated the convulsant activity of bicuculline, but not that of strychnine." | 1.26 | Naloxone as a GABA antagonist: evidence from iontophoretic, receptor binding and convulsant studies. ( Breuker, E; Dingledine, R; Iversen, LL, 1978) |
| "L-Cycloserine was also a potent in vitro inhibitor of brain GABA-T activity." | 1.26 | Effect of L-cycloserine on brain GABA metabolism. ( Gorecki, DK; Peesker, SJ; Tsui, D; Wood, JD, 1978) |
| "We conclude that the acute antiseizure action of taurine, and its effect on restoring normal amino acid patterns in the cortex, represent two separate properties of taurine." | 1.26 | Influence of taurine dosage on cobalt epilepsy in mice. ( Carruthers-Jones, DI; van Gelder, NM, 1978) |
| "Papaverine in low doses was ineffective, but in higher doses lowered PSAT; it antagonized the effect of GAMA, elevating the threshold." | 1.26 | [Effects of imidazole, papaverine and theophylline on the picrotoxin convulsion-seizure threshold. The correlation with gamma-aminobutyric acid (GABA) and diazepam]. ( Georgiev, V, 1978) |
| "During the convulsions by TSC 16hr after the AOAA-pretreatment, the GABA content in synaptosomes was less than that from the group treated with AOAA alone, though its GABA level was higher than the normal level." | 1.26 | Relationship between gamma-aminobutyric acid metabolism and antivitamin B6-induced convulsions. ( Abe, M, 1978) |
| "It protects mice against seizures induced by audiogenic stimuli, electroshock, thiosemicarbazide, isoniazid and strychnine." | 1.26 | Antiseizure activity of gamma-acetylenic gamma-aminobutyric acid: a catalytic irreversible inhibitor of gamma-aminobutyric acid transaminase. ( Jung, MJ; Schechter, PJ; Sjoerdsma, A; Tranier, Y, 1977) |
| "Thus, audiogenic seizure protection in genetically susceptible mice is apparently a function of whole brain GABA concentrations." | 1.26 | Audiogenic seizure protection by elevated brain GABA concentration in mice: effects of gamma-acetylenic gaba and gamma-vinyl GABA, two irreversible GABA-T inhibitors. ( Böhlen, P; Jung, MJ; Schechter, PJ; Tranier, Y, 1977) |
| "Susceptibility to audiogenic seizures can be induced in some strains of resistant mice by exposure to an initial auditory stimulus (acoustic priming)." | 1.26 | Pharmacogenetic differences in audiogenic seizure priming of C57BL/6Bg and DBA/1Bg-asr mice. ( Cowen, JS; Maxson, SC; Sze, PY, 1977) |
| "In rabbits epileptiform seizures were induced by systemic application of methoxypyridoxine, an antimetabolite of vitamin B6." | 1.26 | Antivitamin B6 induced ultrastructural changes in the hippocampus of the convulsant rabbit and its biochemical correlates. ( Nitsch, C, 1976) |
| "Diazepam was shown to be highly efficient in preventing the convulsive siezures induced by thiosemicarbazide and connected with GABA insufficiency." | 1.25 | [The mechanism of the anticonvulsive action of diazepam]. ( Molodavkin, GM; Ostrovskaia, RU; Porfir'eva, RP; Zubovskaia, AM, 1975) |
| "The types of seizure patterns were classed as major (including focal) and minor (akinetic, myoclonic and hypsarrhythmic) and the patients were followed for up to one year." | 1.24 | Trial of amino-oxyacetic acid, an anticonvulsant. ( McGREAL, DA; TIBBLES, JA, 1963) |
| "gamma-Aminobutyric acid was inactive and meprobamate caused flaccid paralysis with loss of the righting reflex." | 1.24 | THE ACTION OF SODIUM 4-HYDROXYBUTYRATE ON SPINAL REFLEXES. ( BASIL, B; BLAIR, AM; HOLMES, SW, 1964) |
| "beta-Alanine is a central-nervous-system depressant." | 1.24 | Hyper-beta-alaninemia associated with beta-aminoaciduria and gamma-aminobutyricaciduria, somnolence and seizures. ( Davies, E; Pueschel, S; Scriver, CR, 1966) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 476 (37.48) | 18.7374 |
| 1990's | 244 (19.21) | 18.2507 |
| 2000's | 245 (19.29) | 29.6817 |
| 2010's | 220 (17.32) | 24.3611 |
| 2020's | 85 (6.69) | 2.80 |
| Authors | Studies |
|---|---|
| Sasaki, H | 1 |
| Mori, Y | 1 |
| Nakamura, J | 2 |
| Shibasaki, J | 1 |
| Witiak, DT | 1 |
| Patch, RJ | 1 |
| Enna, SJ | 4 |
| Fung, YK | 1 |
| Plech, T | 1 |
| Kaproń, B | 1 |
| Luszczki, JJ | 15 |
| Paneth, A | 1 |
| Siwek, A | 1 |
| Kołaczkowski, M | 1 |
| Żołnierek, M | 1 |
| Nowak, G | 1 |
| Gunia-Krzyżak, A | 1 |
| Żelaszczyk, D | 1 |
| Rapacz, A | 2 |
| Żesławska, E | 1 |
| Waszkielewicz, AM | 1 |
| Pańczyk, K | 1 |
| Słoczyńska, K | 1 |
| Pękala, E | 1 |
| Nitek, W | 1 |
| Filipek, B | 2 |
| Marona, H | 1 |
| Reddy, DS | 2 |
| Korkmaz, OT | 1 |
| Arkan, S | 1 |
| Öncü-Kaya, EM | 1 |
| Ateş, N | 1 |
| Tunçel, N | 1 |
| Feja, M | 1 |
| Meller, S | 1 |
| Deking, LS | 1 |
| Kaczmarek, E | 1 |
| During, MJ | 3 |
| Silverman, RB | 1 |
| Gernert, M | 3 |
| Ahring, PK | 1 |
| Liao, VWY | 1 |
| Gardella, E | 1 |
| Johannesen, KM | 1 |
| Krey, I | 1 |
| Selmer, KK | 1 |
| Stadheim, BF | 1 |
| Davis, H | 1 |
| Peinhardt, C | 1 |
| Koko, M | 1 |
| Coorg, RK | 1 |
| Syrbe, S | 1 |
| Bertsche, A | 1 |
| Santiago-Sim, T | 1 |
| Diemer, T | 1 |
| Fenger, CD | 1 |
| Platzer, K | 1 |
| Eichler, EE | 1 |
| Lerche, H | 1 |
| Lemke, JR | 1 |
| Chebib, M | 1 |
| Møller, RS | 1 |
| Suthakaran, N | 1 |
| Wiggins, J | 1 |
| Giles, A | 1 |
| Opperman, KJ | 1 |
| Grill, B | 1 |
| Dawson-Scully, K | 2 |
| Masi, G | 1 |
| O'Connor, KC | 1 |
| Waloschková, E | 1 |
| Gonzalez-Ramos, A | 1 |
| Mikroulis, A | 1 |
| Kudláček, J | 1 |
| Andersson, M | 1 |
| Ledri, M | 1 |
| Kokaia, M | 1 |
| Zhou, J | 1 |
| Liang, W | 1 |
| Wang, J | 3 |
| Chen, J | 1 |
| Liu, D | 1 |
| Wang, X | 3 |
| Wu, Y | 4 |
| Zhang, Q | 3 |
| Shen, D | 1 |
| Kandeda, AK | 1 |
| Mabou, ST | 1 |
| Moutchida, C | 1 |
| Sahin, B | 1 |
| Ozdemir, E | 1 |
| Gumus, E | 1 |
| Ergul, M | 1 |
| Taskiran, AS | 1 |
| Tanenhaus, A | 1 |
| Stowe, T | 1 |
| Young, A | 1 |
| McLaughlin, J | 1 |
| Aeran, R | 1 |
| Lin, IW | 1 |
| Li, J | 1 |
| Hosur, R | 1 |
| Chen, M | 2 |
| Leedy, J | 1 |
| Chou, T | 1 |
| Pillay, S | 1 |
| Vila, MC | 1 |
| Kearney, JA | 1 |
| Moorhead, M | 1 |
| Belle, A | 1 |
| Tagliatela, S | 1 |
| Phillips, HN | 1 |
| Tormoehlen, L | 1 |
| Wen, Y | 1 |
| Zhang, G | 1 |
| Liu, L | 2 |
| Zhang, P | 3 |
| Lin, L | 3 |
| Mei, R | 3 |
| Zhang, F | 1 |
| Chen, Y | 1 |
| Li, R | 3 |
| Mermer, F | 1 |
| Poliquin, S | 1 |
| Zhou, S | 1 |
| Ding, Y | 1 |
| Yin, F | 1 |
| Shen, W | 1 |
| Rigsby, K | 1 |
| Xu, D | 1 |
| Mack, T | 1 |
| Nwosu, G | 1 |
| Flamm, C | 1 |
| Stein, M | 1 |
| Kang, JQ | 1 |
| Shukurova, S | 1 |
| Sadek, R | 1 |
| Mekawy, N | 1 |
| Bendaoud, M | 1 |
| Yachou, Y | 1 |
| Mamchyn, A | 1 |
| El Idrissi, A | 2 |
| Kovács, Z | 1 |
| Skatchkov, SN | 1 |
| Szabó, Z | 1 |
| Qahtan, S | 1 |
| Méndez-González, MP | 1 |
| Malpica-Nieves, CJ | 1 |
| Eaton, MJ | 1 |
| Kardos, J | 3 |
| Héja, L | 2 |
| Gurrell, R | 1 |
| Iredale, P | 1 |
| Evrard, A | 1 |
| Duveau, V | 1 |
| Ruggiero, C | 1 |
| Roucard, C | 1 |
| Kienitz, R | 1 |
| Kay, L | 1 |
| Beuchat, I | 1 |
| Gelhard, S | 1 |
| von Brauchitsch, S | 1 |
| Mann, C | 1 |
| Lucaciu, A | 1 |
| Schäfer, JH | 1 |
| Siebenbrodt, K | 1 |
| Zöllner, JP | 1 |
| Schubert-Bast, S | 1 |
| Rosenow, F | 1 |
| Strzelczyk, A | 1 |
| Willems, LM | 1 |
| Gidal, B | 1 |
| Detyniecki, K | 1 |
| Kapur, J | 5 |
| Long, L | 1 |
| Dixon-Salazar, T | 1 |
| Naraine, AS | 1 |
| Aker, R | 1 |
| Sweeney, I | 1 |
| Kalvey, M | 1 |
| Surtel, A | 1 |
| Shanbhag, V | 1 |
| Langton, RL | 1 |
| Sharma, S | 1 |
| Tiarks, GC | 1 |
| Bassuk, AG | 1 |
| Glykys, J | 3 |
| Muhammad Bello, A | 1 |
| Adegoke Salami, H | 1 |
| Samaila Malgwi, I | 1 |
| Musa Chiroma, S | 1 |
| Plumereau, Q | 1 |
| Ebdalla, A | 1 |
| Poulin, H | 1 |
| Appendino, JP | 1 |
| Scantlebury, MH | 1 |
| Au, PYB | 1 |
| Chahine, M | 1 |
| Song, WS | 1 |
| Cho, YS | 1 |
| Oh, SP | 1 |
| Yoon, SH | 1 |
| Kim, YS | 1 |
| Kim, MH | 1 |
| Avoli, M | 8 |
| de Curtis, M | 4 |
| Lévesque, M | 4 |
| Librizzi, L | 2 |
| Uva, L | 2 |
| Wang, S | 3 |
| Rossi, J | 1 |
| Cavallieri, F | 1 |
| Biagini, G | 1 |
| Rizzi, R | 1 |
| Russo, M | 1 |
| Cozzi, S | 1 |
| Giaccherini, L | 1 |
| Pisanello, A | 1 |
| Valzania, F | 1 |
| Shtrygol, S | 3 |
| Zalevskyi, S | 3 |
| Mishchenko, M | 3 |
| Shtrygol, D | 3 |
| Severina, H | 3 |
| Kayal, WE | 3 |
| Georgiyants, V | 3 |
| Zhang, XL | 2 |
| Zhou, JY | 2 |
| Zhang, FL | 2 |
| Chen, YM | 2 |
| Hassan, M | 2 |
| Adotevi, NK | 1 |
| Leitch, B | 3 |
| Chan, CK | 2 |
| Lim, KS | 1 |
| Low, SK | 1 |
| Tan, CT | 1 |
| Ng, CC | 1 |
| Weiss, SA | 1 |
| Grattan, DR | 1 |
| Stieve, BJ | 1 |
| Smith, MM | 1 |
| Krook-Magnuson, E | 1 |
| Gonçalves, FB | 1 |
| Garcia-Gomes, MSA | 1 |
| Silva-Sampaio, AC | 1 |
| Kirsten, TB | 1 |
| Bondan, EF | 1 |
| Sandini, TM | 1 |
| Flório, JC | 1 |
| Lebrun, I | 1 |
| Coque, AC | 1 |
| Alexandre-Ribeiro, SR | 1 |
| Massironi, SMG | 1 |
| Mori, CMC | 1 |
| Bernardi, MM | 1 |
| Zayed, AA | 1 |
| Seleem, MM | 1 |
| Darwish, HA | 1 |
| Shaheen, AA | 1 |
| Niquet, J | 1 |
| Nguyen, D | 1 |
| de Araujo Furtado, M | 1 |
| Lumley, L | 1 |
| Tokatly Latzer, I | 1 |
| Bertoldi, M | 1 |
| DiBacco, ML | 1 |
| Arning, E | 1 |
| Tsuboyama, M | 1 |
| MacMullin, P | 2 |
| Sachee, D | 1 |
| Rotenberg, A | 2 |
| Lee, HHC | 2 |
| Aygun, D | 1 |
| Opladen, T | 1 |
| Jeltsch, K | 1 |
| García-Cazorla, À | 1 |
| Roullet, JB | 1 |
| Gibson, KM | 7 |
| Pearl, PL | 4 |
| Chen, LY | 1 |
| Di Cristo, G | 1 |
| Scalmani, P | 1 |
| Shiri, Z | 2 |
| Hajipour, S | 1 |
| Khombi Shooshtari, M | 1 |
| Farbood, Y | 1 |
| Ali Mard, S | 1 |
| Sarkaki, A | 1 |
| Moradi Chameh, H | 1 |
| Sistani Karampour, N | 1 |
| Ghafouri, S | 2 |
| Dilmore, AH | 1 |
| Martino, C | 1 |
| Neth, BJ | 1 |
| West, KA | 1 |
| Zemlin, J | 1 |
| Rahman, G | 1 |
| Panitchpakdi, M | 1 |
| Meehan, MJ | 1 |
| Weldon, KC | 1 |
| Blach, C | 1 |
| Schimmel, L | 1 |
| Kaddurah-Daouk, R | 1 |
| Dorrestein, PC | 1 |
| Knight, R | 1 |
| Craft, S | 1 |
| Khorram, E | 1 |
| Amini, M | 1 |
| Khorrami, M | 1 |
| Bampali, K | 1 |
| Koniuszewski, F | 1 |
| Vogel, FD | 1 |
| Fabjan, J | 1 |
| Andronis, C | 1 |
| Lekka, E | 1 |
| Virvillis, V | 1 |
| Seidel, T | 1 |
| Delaunois, A | 1 |
| Royer, L | 1 |
| Rolf, MG | 1 |
| Giuliano, C | 1 |
| Traebert, M | 1 |
| Roussignol, G | 1 |
| Fric-Bordat, M | 1 |
| Mazelin-Winum, L | 1 |
| Bryant, SD | 1 |
| Langer, T | 1 |
| Ernst, M | 1 |
| van van Hugte, EJH | 1 |
| Schubert, D | 1 |
| Nadif Kasri, N | 1 |
| Nkwingwa, BK | 1 |
| Wado, EK | 1 |
| Foyet, HS | 1 |
| Bouvourne, P | 1 |
| Jugha, VT | 1 |
| Mambou, AHMY | 1 |
| Bila, RB | 1 |
| Taiwe, GS | 3 |
| Kirschstein, T | 1 |
| Köhling, R | 3 |
| Rajput, A | 1 |
| Sharma, P | 1 |
| Kumar, N | 1 |
| Singh, H | 1 |
| Singh, T | 1 |
| Singh, S | 1 |
| Singh Bedi, PM | 1 |
| Singh, B | 1 |
| Arora, S | 1 |
| Kaur, S | 1 |
| Foutsop, AF | 1 |
| Ateufack, G | 1 |
| Adassi, BM | 1 |
| Yassi, FB | 1 |
| Kom, TD | 1 |
| Noungoua, CM | 1 |
| Petsou, A | 1 |
| Ngoupaye, GT | 2 |
| Fasham, J | 1 |
| Huebner, AK | 1 |
| Liebmann, L | 1 |
| Khalaf-Nazzal, R | 1 |
| Maroofian, R | 1 |
| Kryeziu, N | 1 |
| Wortmann, SB | 1 |
| Leslie, JS | 1 |
| Ubeyratna, N | 1 |
| Mancini, GMS | 1 |
| van Slegtenhorst, M | 1 |
| Wilke, M | 1 |
| Haack, TB | 1 |
| Shamseldin, HE | 1 |
| Gleeson, JG | 2 |
| Almuhaizea, M | 1 |
| Dweikat, I | 1 |
| Abu-Libdeh, B | 1 |
| Daana, M | 1 |
| Zaki, MS | 1 |
| Wakeling, MN | 1 |
| McGavin, L | 1 |
| Turnpenny, PD | 1 |
| Alkuraya, FS | 1 |
| Houlden, H | 1 |
| Schlattmann, P | 1 |
| Kaila, K | 1 |
| Crosby, AH | 1 |
| Baple, EL | 1 |
| Hübner, CA | 1 |
| Yakovlev, AV | 1 |
| Kurmashova, E | 1 |
| Gataulina, E | 1 |
| Gerasimova, E | 1 |
| Khalilov, I | 4 |
| Sitdikova, GF | 1 |
| Ciltas, AC | 1 |
| Toy, CE | 1 |
| Güneş, H | 1 |
| Yaprak, M | 1 |
| Jarrar, Q | 1 |
| Ayoub, R | 1 |
| Jarrar, Y | 1 |
| Aburass, H | 1 |
| Goh, KW | 1 |
| Ardianto, C | 1 |
| Ming, LC | 1 |
| Moshawih, S | 1 |
| Alfaqih, H | 1 |
| Xie, Y | 1 |
| Yang, Y | 3 |
| Yuan, X | 1 |
| Liu, Y | 2 |
| He, X | 2 |
| Ali, I | 3 |
| Silva, J | 1 |
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| Ogawa, T | 1 |
| Moriwake, T | 1 |
| Sato, M | 1 |
| Maître, L | 1 |
| Baltzer, V | 1 |
| Tanaka, T | 1 |
| Yonemasu, Y | 1 |
| Goroshinskaia, IA | 1 |
| Sherstnev, KB | 1 |
| Zappulla, RA | 1 |
| Spigelman, MK | 1 |
| Rosen, JJ | 1 |
| Marotta, D | 1 |
| Malis, LI | 1 |
| Holland, JF | 1 |
| Drugan, RC | 1 |
| McIntyre, TD | 1 |
| Alpern, HP | 1 |
| Maier, SF | 1 |
| Bo, GP | 1 |
| Scotto, PA | 1 |
| Mainardi, P | 1 |
| Faverio, A | 1 |
| Chalabian, ZhA | 1 |
| Esaian, NA | 1 |
| Karlsson, A | 1 |
| Fonnum, F | 1 |
| Malthe-Sorenssen, D | 1 |
| Storm-Mathisen, J | 1 |
| Subrahmanyam, K | 1 |
| Adembri, G | 1 |
| Bartolini, A | 1 |
| Bartolini, R | 1 |
| Giotti, A | 1 |
| Zilletti, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A 57-Week, Multicenter, Active-treatment, Open-label Extension Trial of CVL-865 as Adjunctive Therapy in Adults With Drug-Resistant Focal Onset Seizures[NCT04686786] | Phase 2 | 120 participants (Anticipated) | Interventional | 2020-12-08 | Enrolling by invitation | ||
| A Randomized, Double-blind, Placebo-controlled, Parallel Group, Multicenter Trial of CVL-865 as Adjunctive Therapy in Adults With Drug-Resistant Focal Onset Seizures (REALIZE Trial)[NCT04244175] | Phase 2 | 150 participants (Anticipated) | Interventional | 2020-01-27 | Recruiting | ||
| Ketogenic Diet Interventions in Parkinson's Disease: Safeguarding the Gut Microbiome[NCT05469997] | 50 participants (Anticipated) | Interventional | 2023-01-31 | Not yet recruiting | |||
| Ketogenic Diet Effects on the Frequency of Non Epileptic Seizures in Patients With Dissociative Neurological Symptom Disorder: a Pilot Study[NCT05219006] | 17 participants (Actual) | Interventional | 2021-07-15 | Completed | |||
| The Role of Gut Microbiota in Children With Epilepsy Following Ketogenic Diet[NCT05898438] | 20 participants (Anticipated) | Observational | 2019-12-18 | Recruiting | |||
| Prednisolone vs. Vigabatrin in the First-line Treatment of Infantile Spasms[NCT02299115] | Phase 3 | 0 participants (Actual) | Interventional | 2017-09-05 | Withdrawn (stopped due to Most centres are now using oral steroids as 1st line treatment so question of efficacy is no longer of high interest.) | ||
| A Randomized, Double-blind, Parallel-group Multi-center Comparative Flexible-dose Trial Of Pregabalin Versus Gabapentin As Adjunctive Therapy In Subjects With Partial Seizures.[NCT00537940] | Phase 4 | 482 participants (Actual) | Interventional | 2008-02-29 | Completed | ||
| The Study of Pharmacokinetics of Levetiracetam in Patients Undergoing Intermittent Hemodialysis[NCT04511676] | 12 participants (Actual) | Observational | 2018-11-01 | Completed | |||
| Imaging Framework for Testing GABAergic/Glutamatergic Drugs in Bipolar Alcoholics[NCT03220776] | Phase 2 | 54 participants (Actual) | Interventional | 2017-08-07 | Completed | ||
| GABA-WHY Study: Deprescription of Gabapentinoids in Medical Inpatients[NCT04855578] | 160 participants (Actual) | Interventional | 2021-05-28 | Completed | |||
| Efficacy of Pregabalin and Duloxetine in Patients With Painful Diabetic Peripheral Neuropathy (PDPN): the Effect of Pain on Cognitive Function, Sleep and Quality of Life (BLOSSOM)[NCT04246619] | Phase 4 | 254 participants (Actual) | Interventional | 2019-11-12 | Terminated (stopped due to The statistical analysis will still provide relevant results with the same statistical power as initially planned.COVID-19 pandemic prolonged the recruiting period and consequently affected the costs of the clinical trial.) | ||
| A Multi-Center, Double-Blind, Randomized, Placebo-Controlled Study of Neotrofin to Treat Patients With Sensory or Motor Neuropathy Caused by Chemotherapy for Cancer[NCT00041795] | Phase 2 | 50 participants | Interventional | 2002-01-31 | Completed | ||
| Combined PET and MR Investigations of the Pathophysiology of Gilles de la Tourette Syndrome. Part 1: Simultaneous PET and 3T MRI[NCT05232955] | 40 participants (Anticipated) | Observational | 2022-02-28 | Not yet recruiting | |||
| Combined PET and MR Investigations of the Pathophysiology of Gilles de la Tourette Syndrome. Part 2: 7T MRI[NCT05233306] | 60 participants (Anticipated) | Observational | 2022-01-27 | Recruiting | |||
| Effect of Melatonin on Seizure Outcome, Neuronal Damage and Quality of Life in Patients With Generalized Epilepsy: A Randomized, add-on Placebo-controlled Clinical Trial[NCT03590197] | Phase 4 | 104 participants (Actual) | Interventional | 2018-08-06 | Completed | ||
| The BrainDrugs-Epilepsy Study: A Prospective Open-label Cohort Precision Medicine Study in Epilepsy[NCT05450822] | 550 participants (Anticipated) | Observational | 2022-02-18 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The seizures were recorded by the participants, by a family member, by a caregiver, or by a legal guardian and documented in a daily seizure diary. Participant's 28-day seizure frequency of all partial seizure was assessed during double blind (TP + MP) phase compared with baseline. Total partial seizure is defined as the total number of (simple partial seizure + complex partial seizure + secondary generalized tonic clonic seizure [SGTC]). (NCT00537940)
Timeframe: 6 weeks Baseline, 21 weeks through End of MP for 27 weeks
| Intervention | percent change (Median) |
|---|---|
| Pregabalin | -58.65 |
| Gabapentin | -57.43 |
SGTC Responder is defined as a participant who shows reduction from Baseline to double-blind phase in proportion of 28-Day SGTC Seizure Rate to 28-Day All Partial Seizure Rate. (NCT00537940)
Timeframe: 6 weeks Baseline, 21 weeks through End of MP for 27 weeks
| Intervention | percentage of responders (Number) |
|---|---|
| Pregabalin | 30.8 |
| Gabapentin | 39.8 |
Change in SGTC = (Proportion of SGTC/All Partial Seizure rate during at the double-blind phase) - (Proportion of SGTC/All Partial Seizure rate at Baseline). Negative values indicate reduction from baseline. (NCT00537940)
Timeframe: 6 weeks Baseline, 21 weeks through End of MP for 27 weeks
| Intervention | percentage of all partial seizure/28days (Mean) | |
|---|---|---|
| Baseline (n=114, 114) | Change from Baseline at Double Blind (n=104, 98) | |
| Gabapentin | 59.60 | -2.17 |
| Pregabalin | 56.53 | 1.59 |
HADS: participant rated questionnaire with 2 subscales. Hospital Anxiety and Depression Scale - anxiety (HADS-A) assesses state of generalized anxiety (anxious mood, restlessness, anxious thoughts, panic attacks); Hospital Anxiety and Depression Scale - depression (HADS-D) assesses state of lost interest and diminished pleasure response (lowering of hedonic tone). Each subscale comprised of 7 items with range 0 (no presence of anxiety or depression) to 3 (severe feeling of anxiety or depression). Total score 0 to 21 for each subscale; higher score indicates greater severity of anxiety and depression symptoms. (NCT00537940)
Timeframe: Baseline, Week 21
| Intervention | Units on a scale (Least Squares Mean) | |||
|---|---|---|---|---|
| Baseline HADS-A (n=238, 240) | HADS- A Change at Week 21/ET (n=212, 210) | Baseline HADS-D (n=238, 240) | HADS-D Change at Week 21/ET (n=212, 210) | |
| Gabapentin | 7.60 | -0.83 | 5.65 | -0.42 |
| Pregabalin | 7.82 | -0.92 | 5.94 | -0.59 |
Participant-rated 12-item questionnaire to assess constructs of sleep over past week; 7 subscales: sleep disturbance, snoring, awakened short of breath, sleep adequacy, somnolence (range:0-100); sleep quantity (range:0-24), optimal sleep (yes/no), and 9 item index measures of sleep disturbance provide composite scores: sleep problem summary, overall sleep problem. Except adequacy, optimal sleep and quantity, higher scores=more impairment. Scores transformed (actual raw score [RS] minus lowest possible score divided by possible RS range*100); total score range:0-100; higher score=more intensity of attribute. (NCT00537940)
Timeframe: Baseline, Week 21
| Intervention | Units on a scale (Least Squares Mean) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline: Sleep Disturbance (n=238, 240) | Baseline: Snoring (n=238, 240) | Baseline: Awaken Short of Breath (n=238, 240) | Baseline: Quantity of Sleep (n=238, 240) | Baseline: Adequacy of Sleep (n=238, 240) | Baseline: Somnolence (n=238, 240) | Baseline: Sleep Problem Index (9) (n=238, 240) | Week 21: Sleep Disturbance (n=212, 210) | Week 21: Snoring (n=212, 210) | Week 21: Awaken Short of Breath (n=212, 210) | Week 21: Quantity of Sleep (n=212, 210) | Week 21: Adequacy of Sleep (n=212, 210) | Week 21: Somnolence (n=212, 210) | Week 21: Sleep Problem Index (9) (n=212, 210) | |
| Gabapentin | 26.43 | 28.09 | 19.61 | 7.59 | 63.67 | 29.31 | 28.15 | 25.31 | 26.12 | 18.20 | 8.77 | 64.53 | 29.98 | 27.54 |
| Pregabalin | 29.68 | 29.28 | 23.64 | 7.56 | 61.30 | 32.29 | 31.60 | 24.99 | 28.07 | 16.26 | 8.79 | 63.87 | 32.04 | 27.88 |
Participants who had at least 50% reduction in seizure frequency from Baseline to double-blind treatment (TP + MP) were considered as 50% responders. If percent change from baseline <= -50 then responder rate = 1 (yes) otherwise responder rate = 0 (no). (NCT00537940)
Timeframe: 6 weeks Baseline, 21 weeks through End of MP for 27 weeks
| Intervention | Percentage of participants (Number) | |||
|---|---|---|---|---|
| All Partial Seizure (n=238, 240) | Simple Partial (n=87, 88) | Complex Partial (n=161, 158) | SGTC (n=112, 114) | |
| Gabapentin | 58.3 | 53.4 | 55.1 | 60.5 |
| Pregabalin | 56.3 | 55.2 | 56.5 | 50.9 |
Participants who had at least 75% reduction in seizure frequency from Baseline to double-blind treatment (TP + MP) were considered as 75% responders. If percent change from baseline <= -75 then 75% responder rate = 1 (yes) otherwise responder rate = 0 (no). Total partial seizure is defined as the total number of (simple partial seizure + complex partial seizure + SGTC). (NCT00537940)
Timeframe: 6 weeks Baseline, 21 weeks through End of MP for 27 weeks
| Intervention | Percentage of participants (Number) | |||
|---|---|---|---|---|
| All Partial Seizure (n=238, 240) | Simple Partial (n=87, 88) | Complex Partial (n=161, 158) | SGTC (n=112, 114) | |
| Gabapentin | 34.2 | 33.0 | 36.1 | 43.9 |
| Pregabalin | 33.6 | 36.8 | 37.3 | 38.4 |
MOS-SS: participant-rated 12 item questionnaire to assess constructs of sleep over past week. It included 7 subscales: sleep disturbance, snoring, awakened short of breath, sleep adequacy, somnolence, sleep quantity and optimal sleep. Participants responded whether their sleep was optimal or not by choosing yes or no. Percentage of participants with optimal sleep are reported. (NCT00537940)
Timeframe: Baseline, Week 21
| Intervention | percentage of participants (Number) | |
|---|---|---|
| Baseline (n=238, 240) | Week 21 (n=212, 210) | |
| Gabapentin | 58.8 | 58.6 |
| Pregabalin | 49.2 | 51.4 |
Seizure free for 28 days was defined as participants who have not experienced any seizure (simple partial, complex partial and SGTC) for at least 28 consecutive days from their last seizure until the end of the MP. Same participant could be seizure free for a specific type of seizure but not necessarily for the other types of seizure. (NCT00537940)
Timeframe: 6 weeks Baseline, 21 weeks through End of MP for 27 weeks
| Intervention | percentage of participants (Number) | |||
|---|---|---|---|---|
| All Partial Seizure (n=189, 182) | Simple Partial (n=74, 66) | Complex Partial (n=126, 123) | SGTC (n=95, 91) | |
| Gabapentin | 34.1 | 36.4 | 40.7 | 42.9 |
| Pregabalin | 30.7 | 29.7 | 37.3 | 46.3 |
Concentrations of GABA+, referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy (i.e., MEGA-PRESS). (NCT03220776)
Timeframe: Day 5 of each experimental condition
| Intervention | mmol/kg (Mean) |
|---|---|
| N-Acetylcysteine | 3.90 |
| Gabapentin | 3.93 |
| Placebo Oral Tablet | 3.73 |
Concentrations of Glx (i.e., glutamate + glutamine), referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy. (NCT03220776)
Timeframe: Day 5 of each experimental condition
| Intervention | mmol/kg (Mean) |
|---|---|
| N-Acetylcysteine | 21.59 |
| Gabapentin | 21.69 |
| Placebo Oral Tablet | 22.25 |
127 reviews available for gamma-aminobutyric acid and Seizures
| Article | Year |
|---|---|
Neurosteroid replacement therapy for catamenial epilepsy, postpartum depression and neuroendocrine disorders in women.
Topics: Depression, Postpartum; Epilepsy, Reflex; Female; gamma-Aminobutyric Acid; Humans; Neurosteroids; Ne | 2022 |
Toxin-Induced Seizures
Topics: gamma-Aminobutyric Acid; Humans; Seizures | 2022 |
Benzodiazepines in the Management of Seizures and Status Epilepticus: A Review of Routes of Delivery, Pharmacokinetics, Efficacy, and Tolerability.
Topics: Anticonvulsants; Benzodiazepines; Clonazepam; Diazepam; gamma-Aminobutyric Acid; Humans; Lorazepam; | 2022 |
Rescue therapies for seizure clusters: Pharmacology and target of treatments.
Topics: Administration, Intranasal; Adolescent; Adult; Anticonvulsants; Benzodiazepines; Diazepam; Epilepsy, | 2022 |
GABA
Topics: Animals; Electroencephalography; Epilepsies, Partial; Epilepsy; Epilepsy, Temporal Lobe; gamma-Amino | 2022 |
Epileptogenesis and Tumorigenesis in Glioblastoma: Which Relationship?
Topics: Aquaporins; Brain Neoplasms; Cell Transformation, Neoplastic; gamma-Aminobutyric Acid; Glioblastoma; | 2022 |
Chloride ion dysregulation in epileptogenic neuronal networks.
Topics: Chlorides; gamma-Aminobutyric Acid; Humans; Neurons; Receptors, GABA-A; Seizures; Synaptic Transmiss | 2023 |
Treatment of cholinergic-induced status epilepticus with polytherapy targeting GABA and glutamate receptors.
Topics: Acetylcholinesterase; Animals; Anticonvulsants; Benzodiazepines; Cholinergic Agents; gamma-Aminobuty | 2023 |
Ligand-gated mechanisms leading to ictogenesis in focal epileptic disorders.
Topics: Animals; Epilepsies, Partial; gamma-Aminobutyric Acid; Humans; Ligands; Receptors, GABA-A; Seizures; | 2023 |
Excitatory/inhibitory balance in epilepsies and neurodevelopmental disorders: Depolarizing γ-aminobutyric acid as a common mechanism.
Topics: Epilepsy; gamma-Aminobutyric Acid; Humans; Neurodevelopmental Disorders; Seizures | 2023 |
Functional changes in neuronal circuits due to antibody-driven autoimmune response.
Topics: Autoantibodies; Autoimmunity; gamma-Aminobutyric Acid; Humans; Intracellular Signaling Peptides and | 2023 |
GABA
Topics: Baclofen; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Re | 2022 |
GABA
Topics: Adult; Epilepsies, Partial; gamma-Aminobutyric Acid; Humans; Receptors, GABA-A; Receptors, GABA-B; S | 2022 |
Double-edged GABAergic synaptic transmission in seizures: The importance of chloride plasticity.
Topics: Animals; Chlorides; Epilepsy; GABA Agents; GABAergic Neurons; gamma-Aminobutyric Acid; Humans; K Cl- | 2018 |
The paradox of the paroxysm: can seizure precipitants help explain human ictogenesis?
Topics: Animals; Brain; gamma-Aminobutyric Acid; Humans; Neurotransmitter Agents; Parasomnias; Seizures | 2013 |
Cerebal overinhibition could be the basis for the high prevalence of epilepsy in persons with Down syndrome.
Topics: Animals; Brain; Down Syndrome; Epilepsy; Female; gamma-Aminobutyric Acid; Humans; Mice; Neural Inhib | 2015 |
Mechanisms of Action of Antiseizure Drugs and the Ketogenic Diet.
Topics: Animals; Anticonvulsants; Brain; Diet, Ketogenic; Epilepsy; gamma-Aminobutyric Acid; Humans; Ion Cha | 2016 |
GABAergic networks jump-start focal seizures.
Topics: Animals; Brain; gamma-Aminobutyric Acid; Humans; Interneurons; Nerve Net; Seizures | 2016 |
Antiepileptic dosing for critically ill adult patients receiving renal replacement therapy.
Topics: Acetamides; Acute Kidney Injury; Amines; Anticonvulsants; Carbamates; Critical Illness; Cyclohexanec | 2016 |
Reduction of secondarily generalized tonic-clonic (SGTC) seizures with pregabalin.
Topics: Anticonvulsants; Dose-Response Relationship, Drug; Double-Blind Method; Drug Resistance, Multiple; E | 2008 |
Emergent complications of the newer anticonvulsants.
Topics: Acidosis; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Overdose; Fructo | 2010 |
[Gamma-aminobutyric acid--metabolism and its disorders].
Topics: Anxiety Disorders; Central Nervous System Diseases; Fatigue Syndrome, Chronic; gamma-Aminobutyric Ac | 2007 |
The epileptic hypothesis: developmentally related arguments based on animal models.
Topics: Age Factors; Animals; Brain; Child, Preschool; Cognition Disorders; Developmental Disabilities; Dise | 2009 |
New antiepileptic drugs: molecular targets.
Topics: Action Potentials; Animals; Anticonvulsants; Barbiturates; Carbamazepine; Clinical Trials as Topic; | 2009 |
Mutations affecting GABAergic signaling in seizures and epilepsy.
Topics: Angelman Syndrome; Animals; Channelopathies; Chloride Channels; Chlorides; CLC-2 Chloride Channels; | 2010 |
Pharmacology of antiepileptic drugs in clinical practice.
Topics: Anticonvulsants; Calcium Channel Blockers; Calcium Channels; GABA Agonists; gamma-Aminobutyric Acid; | 2010 |
Alterations in the expression of neuronal chloride transporters may contribute to schizophrenia.
Topics: Age Factors; Animals; Chlorides; Epilepsy; gamma-Aminobutyric Acid; Humans; Mice; Neural Stem Cells; | 2011 |
GABA transport inhibitors and seizure protection: the past and future.
Topics: Anticonvulsants; Astrocytes; Biological Transport; GABA Plasma Membrane Transport Proteins; gamma-Am | 2011 |
Altered GABA signaling in early life epilepsies.
Topics: Aging; Child, Preschool; Epilepsy; Female; gamma-Aminobutyric Acid; Humans; Infant; Infant, Newborn; | 2011 |
Genes and molecular mechanisms involved in the epileptogenesis of idiopathic absence epilepsies.
Topics: Adolescent; Alleles; Animals; Calcium Channels; Child; Disease Models, Animal; Epilepsy, Absence; ga | 2012 |
Cytokines and brain excitability.
Topics: Akathisia, Drug-Induced; Animals; Brain; Cytokines; Down-Regulation; Epilepsy; gamma-Aminobutyric Ac | 2012 |
Glutamate and GABA synthesis, release, transport and metabolism as targets for seizure control.
Topics: Animals; Animals, Genetically Modified; Biological Transport; gamma-Aminobutyric Acid; Glutamic Acid | 2012 |
Drug safety evaluation of pregabalin.
Topics: Anticonvulsants; Evidence-Based Medicine; gamma-Aminobutyric Acid; Humans; Patient Safety; Pregabali | 2012 |
Progress in studies on the role of gamma-aminobutyric acid.
Topics: Animals; Anticonvulsants; gamma-Aminobutyric Acid; Humans; Receptors, GABA; Seizures | 2012 |
How inhibition influences seizure propagation.
Topics: Animals; Anticonvulsants; Electrical Synapses; Electrophysiology; Epilepsy; gamma-Aminobutyric Acid; | 2013 |
Does interictal synchronization influence ictogenesis?
Topics: Animals; Disease Models, Animal; Electroencephalography Phase Synchronization; Epilepsy, Temporal Lo | 2013 |
Alcohol and drugs in epilepsy: pathophysiology, presentation, possibilities, and prevention.
Topics: Alcohol Drinking; Alcohol Withdrawal Seizures; Alcoholism; Amphetamine-Related Disorders; Benzodiaze | 2012 |
Ictogenesis and epileptogenesis in EL mice.
Topics: Animals; DNA Fragmentation; Epilepsy; gamma-Aminobutyric Acid; Gene Expression; Genes, Immediate-Ear | 2002 |
Functional and morphological changes in the hippocampal neuronal circuits associated with epileptic seizures.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Electrophysiology; Excitatory Postsynaptic Potential | 2002 |
Pyridoxine-dependent seizures: a clinical and biochemical conundrum.
Topics: Drug Overdose; gamma-Aminobutyric Acid; Humans; Pyridoxal Phosphate; Pyridoxine; Seizures | 2003 |
Cellular and molecular action of the putative GABA-mimetic, gabapentin.
Topics: Acetates; Amines; Analgesics; Animals; Anticonvulsants; Anxiety; Brain; Cyclohexanecarboxylic Acids; | 2003 |
[ROLE OF GAMMA-AMINOBUTYRIC ACID IN CONVULSIVE STATES. (REVIEW OF THE LITERATURE)].
Topics: Aminobutyrates; Anticonvulsants; Brain Chemistry; Drug Therapy; Epilepsy; gamma-Aminobutyric Acid; H | 1963 |
GAMMA-AMINOBUTYRIC ACID AND OTHER INHIBITORY SUBSTANCES.
Topics: Amino Acids; Aminobutyrates; Ammonia; Brain Chemistry; gamma-Aminobutyric Acid; Glucose; Glutamates; | 1965 |
Pregabalin (Pfizer).
Topics: Analgesics, Non-Narcotic; Animals; Anticonvulsants; Anxiety Disorders; Clinical Trials, Phase II as | 2004 |
Optimal seizure management in brain tumor patients.
Topics: Amines; Anticonvulsants; Antineoplastic Agents; Brain Neoplasms; Cyclohexanecarboxylic Acids; Drug I | 2005 |
Pregabalin: a new neuromodulator with broad therapeutic indications.
Topics: Agoraphobia; Anxiety; Diabetic Neuropathies; Epilepsy; gamma-Aminobutyric Acid; Herpesviridae Infect | 2005 |
[Neonatal epilepsy and inborn errors of metabolism].
Topics: Age Factors; Anticonvulsants; Biotin; Brain; Electroencephalography; Epilepsies, Myoclonic; Epilepsy | 2006 |
GABA: a pioneer transmitter that excites immature neurons and generates primitive oscillations.
Topics: Animals; gamma-Aminobutyric Acid; Neuronal Plasticity; Neurons; Seizures; Signal Transduction; Synap | 2007 |
Neurobiological mechanisms of developmental epilepsy: translating experimental findings into clinical application.
Topics: Adolescent; Brain; Child; Epilepsy; gamma-Aminobutyric Acid; Humans; Neuronal Plasticity; Receptors, | 2007 |
[Cellular mechanisms of the epilepsies: In vitro studies on human tissue].
Topics: Cerebral Cortex; Electrophysiology; Epilepsy; gamma-Aminobutyric Acid; Humans; In Vitro Techniques; | 2008 |
Epilepsy and antiepileptic drugs: a speculative synthesis.
Topics: Animals; Anticonvulsants; Epilepsy; gamma-Aminobutyric Acid; Humans; Immunochemistry; Membranes; Neu | 1980 |
Neurochemical correlates of the kindling model of epilepsy.
Topics: Acetylcholine; Amino Acids; Animals; Brain; Cyclic AMP; Cyclic GMP; Dopamine; Evoked Potentials; gam | 1982 |
The mechanism(s) of action of the benzodiazepines.
Topics: Adenosine; Animals; Anti-Anxiety Agents; Anxiety Disorders; Benzodiazepines; Caffeine; Carbolines; C | 1981 |
[Clinical biochemistry of epilepsy--specially regarding to neurotransmitters].
Topics: Animals; Biogenic Amines; Catecholamines; Cyclic AMP; Cyclic GMP; Epilepsy; gamma-Aminobutyric Acid; | 1982 |
Studies of neurotransmitter actions (GABA, glycine, and convulsants).
Topics: Amino Acids; Animals; Brain; Central Nervous System; Convulsants; GABA Antagonists; gamma-Aminobutyr | 1983 |
Neurotransmitter and neuromodulator function in the kindled seizure and state.
Topics: Amygdala; Animals; Biogenic Amines; Brain; Convulsants; Cyclic AMP; Cyclic GMP; Electric Stimulation | 1982 |
On the sacred disease: the neurochemistry of epilepsy.
Topics: Acetylcholine; Amino Acids; Animals; Anticonvulsants; Brain; Catecholamines; Convulsants; Disease Mo | 1983 |
[Toxic action of kainic acid as a model of Huntington chorea and epilepsy (review)].
Topics: Animals; Anticonvulsants; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Drug Interactio | 1983 |
Physiological and behavioral studies with muscimol.
Topics: Animals; Behavior; Behavior, Animal; Blood-Brain Barrier; Dopamine; Feeding Behavior; gamma-Aminobut | 1980 |
The GABA postsynaptic membrane receptor-ionophore complex. Site of action of convulsant and anticonvulsant drugs.
Topics: Anticonvulsants; Barbiturates; Benzodiazepines; Bicuculline; Brain; Chlorides; Convulsants; Diazepam | 1981 |
Cellular compartments of GABA in brain and their relationship to anticonvulsant activity.
Topics: 4-Aminobutyrate Transaminase; Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; | 1981 |
Central actions of valproic acid in man and in experimental models of epilepsy.
Topics: 4-Aminobutyrate Transaminase; Action Potentials; Alcohol Oxidoreductases; Aldehyde Oxidoreductases; | 1981 |
GABA binding processes and behavior.
Topics: Aging; Animals; Basal Ganglia Diseases; Behavior; Behavior, Animal; Epilepsy; Extrapyramidal Tracts; | 1983 |
Anticonvulsant and antidepressant properties of electroconvulsive therapy: a proposed mechanism of action.
Topics: Animals; Brain; Depressive Disorder; Electroconvulsive Therapy; Epilepsy; gamma-Aminobutyric Acid; H | 1983 |
Benzodiazepine receptor ligands with positive and negative efficacy.
Topics: Acoustic Stimulation; Animals; Carbolines; Chlorides; gamma-Aminobutyric Acid; Humans; Ligands; Rece | 1983 |
Mechanisms of action of antiepileptic drugs.
Topics: Animals; Anticonvulsants; Anura; Electrolytes; gamma-Aminobutyric Acid; Humans; Muscle Contraction; | 1983 |
Studies on homopantothenic acid.
Topics: Alanine; Animals; Biological Availability; Blood-Brain Barrier; Brain; gamma-Aminobutyric Acid; Ison | 1984 |
Morphological, biochemical, and immunocytochemical changes of the cortical, GABAergic system in epileptic foci.
Topics: Aluminum Oxide; Animals; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Haplorhi | 1983 |
Neurologic manifestations of acute porphyria.
Topics: Acute Disease; Aminolevulinic Acid; Animals; Central Nervous System; Depression; Electrophysiology; | 1982 |
Inhibitory amino acids, aggressiveness, and convulsions.
Topics: Aggression; Amino Acids; Animals; Anticonvulsants; gamma-Aminobutyric Acid; Humans; Seizures; Taurin | 1981 |
A review of the preclinical pharmacology of tiagabine: a potent and selective anticonvulsant GABA uptake inhibitor.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain Ischemia; Dogs; gamma-Aminobutyric Acid; Humans; I | 1995 |
The role of the inferior colliculus in a genetic model of audiogenic seizures.
Topics: Acoustic Stimulation; Animals; Disease Models, Animal; Disease Susceptibility; Epilepsy; gamma-Amino | 1995 |
Pro- and anticonvulsant effects of stress: the role of neuroactive steroids.
Topics: Animals; Anticonvulsants; gamma-Aminobutyric Acid; Humans; Seizures; Steroids; Stress, Psychological | 1993 |
Seizure control: how to use the new antiepileptic drugs in older patients.
Topics: Acetates; Age Factors; Aged; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Drug Interactions | 1996 |
Clinical use of drugs useful in the treatment of atonic seizures.
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Clobazam; Epilepsy, Genera | 1995 |
Gamma hydroxybutyrate is not a GABA agonist.
Topics: 4-Butyrolactone; Animals; Central Nervous System; Convulsants; Electroencephalography; GABA Agonists | 1996 |
The gamma-hydroxybutyrate signalling system in brain: organization and functional implications.
Topics: Animals; Brain; gamma-Aminobutyric Acid; Humans; Mammals; Models, Neurological; Rats; Receptors, GAB | 1997 |
A review of the newer antiepileptic drugs and the ketogenic diet.
Topics: Acetates; Age Factors; Amines; Anticonvulsants; Child; Child, Preschool; Cyclohexanecarboxylic Acids | 1997 |
Antibiotic-induced convulsions.
Topics: Anti-Bacterial Agents; gamma-Aminobutyric Acid; Humans; Receptors, GABA; Risk Factors; Seizures | 1997 |
Anticonvulsant therapy in small animals.
Topics: Acetates; Amines; Animals; Anticonvulsants; Bromides; Clonazepam; Clorazepate Dipotassium; Cyclohexa | 1998 |
[Pyridoxine dependency with seizures].
Topics: Amino Acid Metabolism, Inborn Errors; Brain; Diagnosis, Differential; gamma-Aminobutyric Acid; Gluta | 1998 |
Current perspectives on pyridoxine-dependent seizures.
Topics: Anticonvulsants; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Humans; Infant; Infant, Newborn; | 1998 |
[Vitamin B6 dependency syndrome (vitamin B6 dependent seizures, convulsions)].
Topics: Biomarkers; Electroencephalography; gamma-Aminobutyric Acid; Humans; Infant, Newborn; Prognosis; Pyr | 1998 |
Ethanol and neurotransmitter interactions--from molecular to integrative effects.
Topics: Animals; Brain; Ethanol; Excitatory Amino Acids; gamma-Aminobutyric Acid; Humans; Neural Inhibition; | 1998 |
[GABAergic mechanisms in generalized epilepsies: the neuroanatomical dimension].
Topics: Animals; Central Nervous System; Disease Models, Animal; Epilepsy, Generalized; gamma-Aminobutyric A | 1997 |
Seizures: classification, etiologies, and pathophysiology.
Topics: Animals; Brain Injuries; Cat Diseases; Cats; Cerebral Cortex; Dog Diseases; Dogs; Electroencephalogr | 1998 |
Antiepileptic drug therapy.
Topics: Acetates; Amines; Animals; Anticonvulsants; Bromides; Cat Diseases; Cats; Cyclohexanecarboxylic Acid | 1998 |
[Gene expression of glutamic acid decarboxylase during neural development and activity].
Topics: Animals; Brain; gamma-Aminobutyric Acid; Gene Expression Regulation, Enzymologic; Glutamate Decarbox | 2000 |
A noradrenergic and serotonergic hypothesis of the linkage between epilepsy and affective disorders.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Brain Chemistry; Causality; Depression; Disease Mod | 1999 |
Kainate, a double agent that generates seizures: two decades of progress.
Topics: Animals; Disease Models, Animal; Electric Conductivity; Epilepsy, Temporal Lobe; Excitatory Amino Ac | 2000 |
Epilepsy-associated plasticity in gamma-aminobutyric acid receptor expression, function, and inhibitory synaptic properties.
Topics: Animals; Epilepsy; gamma-Aminobutyric Acid; Humans; Neuronal Plasticity; Receptors, GABA; Seizures; | 2001 |
Cell death and synaptic reorganizations produced by seizures.
Topics: Animals; Cell Death; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Hippocampus; Humans; In Vitro | 2001 |
SCH 23390: the first selective dopamine D1-like receptor antagonist.
Topics: Animals; Anticonvulsants; Antipsychotic Agents; Behavior, Animal; Benzazepines; Brain; Dopamine; Dop | 2001 |
SCH 23390: the first selective dopamine D1-like receptor antagonist.
Topics: Animals; Anticonvulsants; Antipsychotic Agents; Behavior, Animal; Benzazepines; Brain; Dopamine; Dop | 2001 |
SCH 23390: the first selective dopamine D1-like receptor antagonist.
Topics: Animals; Anticonvulsants; Antipsychotic Agents; Behavior, Animal; Benzazepines; Brain; Dopamine; Dop | 2001 |
SCH 23390: the first selective dopamine D1-like receptor antagonist.
Topics: Animals; Anticonvulsants; Antipsychotic Agents; Behavior, Animal; Benzazepines; Brain; Dopamine; Dop | 2001 |
Adolescent seizures and epilepsy syndromes.
Topics: Adolescent; Age Factors; Brain; Child; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; Es | 2002 |
[Interactions of neurotransmitters].
Topics: Acetylcholine; Adrenocorticotropic Hormone; Animals; Benzodiazepines; Catecholamines; Cats; Corpus S | 1978 |
[Mechanisms of local anesthetic seizures (author's transl)].
Topics: Anesthetics, Local; Animals; Benzodiazepines; Biogenic Amines; Brain; Cats; gamma-Aminobutyric Acid; | 1979 |
Audiogenic seizures in mice.
Topics: Acoustic Stimulation; Aging; Animals; Cerebellum; gamma-Aminobutyric Acid; Mice; Mice, Inbred A; Mic | 1979 |
Photomyoclonic seizures in the baboon, Papio papio.
Topics: Amines; Animals; Anticonvulsants; Behavior, Animal; Benzodiazepinones; Disease Models, Animal; Ethin | 1979 |
[Pharmacologic approach to Papio papio photosensitive epilepsy].
Topics: Animals; Anticonvulsants; Dopamine; gamma-Aminobutyric Acid; Haplorhini; Norepinephrine; Papio; Phot | 1978 |
Valproic acid. Review of a new antiepileptic drug.
Topics: Adolescent; Adult; Animals; Brain Chemistry; Drug Interactions; Electric Stimulation; Electroencepha | 1979 |
Epilepsy and gamma-aminobutyric acid-mediated inhibition.
Topics: 4-Aminobutyrate Transaminase; Aminobutyrates; Animals; Anticonvulsants; Bicuculline; Brain; Epilepsy | 1975 |
New concepts on the mechanism of action of benzodiazepines.
Topics: Animals; Benzodiazepines; Cerebellum; Chlordiazepoxide; Cyclic AMP; Diazepam; gamma-Aminobutyric Aci | 1975 |
Evidence for involvement of GABA in the action of benzodiazepines: studies on rat cerebellum.
Topics: Aminobutyrates; Animals; Anti-Anxiety Agents; Benzodiazepines; Cerebellum; Cyclic GMP; gamma-Aminobu | 1975 |
The role of gamma-aminobutyric acid in the mechanism of seizures.
Topics: Animals; Brain; gamma-Aminobutyric Acid; Humans; Seizures | 1975 |
The dentate gyrus as a control point for seizures in the hippocampus and beyond.
Topics: Afferent Pathways; Amygdala; Animals; Brain Mapping; Epilepsy; gamma-Aminobutyric Acid; Hippocampus; | 1992 |
Role of GABA in the genesis of chemoconvulsant seizures.
Topics: Animals; Brain; gamma-Aminobutyric Acid; Humans; Receptors, GABA-A; Seizures; Synaptic Transmission | 1992 |
Pharmacological, toxicological and neurochemical effects of delta 2(E)-valproate in animals.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Brain; Fatty Acids, Monounsaturated; gamma-Am | 1992 |
Intracerebral grafting of inhibitory neurons. A new strategy for seizure suppression in the central nervous system.
Topics: Animals; Brain; Brain Tissue Transplantation; gamma-Aminobutyric Acid; Humans; Neurons; Seizures | 1992 |
GABA neurons in seizure disorders: a review of immunocytochemical studies.
Topics: Animals; Epilepsy; gamma-Aminobutyric Acid; Immunohistochemistry; Microscopy, Electron; Neurons; Sei | 1991 |
[Are there glutamatergic, anti-GABAergic or antiglycinergic components in the action mechanism of adamantamines? Study of convulsions induced by amantadine or 1-adamantylcyclopentanamine in mice].
Topics: Amantadine; Animals; Convulsants; GABA Antagonists; gamma-Aminobutyric Acid; Glutamates; Glycine; Ma | 1990 |
Hippocampal zinc thionein and pyridoxal phosphate modulate synaptic functions.
Topics: Animals; Brain; Enzyme Activation; gamma-Aminobutyric Acid; Hippocampus; Metallothionein; Pyridoxal | 1990 |
How do seizures begin? Clues from hippocampal slices.
Topics: Animals; Computer Simulation; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Seizures | 1988 |
The effects of neurotoxicants on kindling and kindled seizures.
Topics: Acetylcholine; Animals; Anticonvulsants; Brain; Brain Chemistry; Cats; Dieldrin; Dopamine; Electric | 1985 |
[GABA and various antiepileptic drugs].
Topics: Animals; Anticonvulsants; Epilepsy; gamma-Aminobutyric Acid; Receptors, GABA-A; Seizures | 1987 |
[GABAergic substances in pharmacology].
Topics: 4-Aminobutyrate Transaminase; Animals; Anxiety; Depression; GABA Antagonists; gamma-Aminobutyric Aci | 1987 |
Progression and generalization of seizure discharge: anatomical and neurochemical substrates.
Topics: Amino Acids; Animals; Anticonvulsants; Basal Ganglia; Brain; Brain Stem; Convulsants; Disease Models | 1988 |
Benzodiazepines and the developing rat: a critical review.
Topics: Aging; Animals; Animals, Newborn; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Brain; Bra | 1985 |
[Implications of GABAergic synapses in neuropsychiatry].
Topics: 4-Aminobutyrate Transaminase; Animals; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; | 1985 |
Drugs acting on amino acid neurotransmitters.
Topics: Acoustic Stimulation; Amino Acids; Animals; Chemical Phenomena; Chemistry; Diazepam; Electrophysiolo | 1986 |
Electroconvulsive therapy as an anticonvulsant. Implications for its mechanism of action in affective illness.
Topics: Amygdala; Animals; Anticonvulsants; Antidepressive Agents; Cats; Cerebral Cortex; Diethylcarbamazine | 1986 |
Gamma-vinyl GABA.
Topics: 4-Aminobutyrate Transaminase; Amino Acids; Aminocaproates; Animals; Behavior, Animal; beta-Alanine; | 1985 |
Mechanisms of seizure control mediated by gamma-aminobutyric acid: role of the substantia nigra.
Topics: Animals; Bicuculline; Cell Compartmentation; Epilepsy; gamma-Aminobutyric Acid; Microinjections; Mor | 1985 |
Benzodiazepine/barbiturate/GABA receptor-chloride ionophore complex in a genetic model for generalized epilepsy.
Topics: Animals; Anticonvulsants; Barbiturates; Benzodiazepines; Binding Sites; Chlorides; Disease Models, A | 1986 |
Failure of GABAergic inhibition: a key to local and global seizures.
Topics: Animals; Basal Ganglia; Cerebral Cortex; Endocrine Glands; Epilepsies, Partial; gamma-Aminobutyric A | 1986 |
Dosage, seizure threshold, and the antidepressant efficacy of electroconvulsive therapy.
Topics: Animals; Cats; Cerebral Cortex; Depressive Disorder; Electroconvulsive Therapy; Endorphins; Epilepsi | 1986 |
Antidepressants and convulsive seizures: clinical, electroencephalographic, and pharmacological aspects.
Topics: Adult; Age Factors; Aged; Animals; Antidepressive Agents; Catecholamines; Computers; Diagnosis, Diff | 1986 |
[Biochemistry, physiology and pharmacology of gamma-aminobutyric acid].
Topics: Aminobutyrates; Animals; Blood-Brain Barrier; Carboxy-Lyases; Central Nervous System; Crustacea; gam | 1972 |
22 trials available for gamma-aminobutyric acid and Seizures
| Article | Year |
|---|---|
The efficacy of gabapentin in children of partial seizures and the blood levels.
Topics: Adolescent; Age Factors; Amines; Anticonvulsants; Child; Child, Preschool; Cyclohexanecarboxylic Aci | 2014 |
Designing a new proof-of-principle trial for treatment of partial seizures to demonstrate efficacy with minimal sample size and duration-a case study.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Clinical Trials, Phase III as Topic; Databases, Factual; D | 2013 |
Adjunctive pregabalin vs gabapentin for focal seizures: Interpretation of comparative outcomes.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amines; Anticonvulsants; Child; Cyclohexanecarboxylic Ac | 2016 |
Pregabalin: preliminary experience in intractable childhood epilepsy.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Cognition Disorders; Drug Therapy, Combination | 2009 |
Experience in the use of the anticonvulsant pregabalin as an add-on therapy in patients with partial epilepsy with polymorphic seizures.
Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Carbamazepine; Databases as Topic; Drug Therapy, C | 2010 |
A comparison of pregabalin, lamotrigine, and placebo as adjunctive therapy in patients with refractory partial-onset seizures.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Dizziness; Double-Blind Method; Epilepsies, Partial; Fem | 2010 |
Gabapentin in late-onset poststroke seizures.
Topics: Acetates; Aged; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Dr | 2002 |
Gabapentin to control seizures in children undergoing cancer treatment.
Topics: Acetates; Amines; Anticonvulsants; Antineoplastic Agents; Brain; Child; Cyclohexanecarboxylic Acids; | 2004 |
Bodyweight gain under pregabalin therapy in epilepsy: mitigation by counseling patients?
Topics: Adult; Anticonvulsants; Body Mass Index; Counseling; Diet; Epilepsy; Exercise; Female; Follow-Up Stu | 2008 |
Gabapentin toxicity in children manifesting as behavioral changes.
Topics: Acetates; Affect; Aggression; Amines; Anticonvulsants; Behavior; Child; Cyclohexanecarboxylic Acids; | 1995 |
Seizure frequency and CSF parameters in a double-blind placebo controlled trial of gabapentin in patients with intractable complex partial seizures.
Topics: Acetates; Adolescent; Adult; Aged; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Dose-Respon | 1995 |
Human brain gamma-aminobutyric acid levels and seizure control following initiation of vigabatrin therapy.
Topics: Adult; Anticonvulsants; Epilepsy, Complex Partial; Female; gamma-Aminobutyric Acid; Humans; Male; Mi | 1996 |
Pharmacokinetics of the individual enantiomers of vigabatrin in neonates with uncontrolled seizures.
Topics: Anticonvulsants; Area Under Curve; gamma-Aminobutyric Acid; Gas Chromatography-Mass Spectrometry; Ha | 1996 |
Multicentre clinical evaluation of vigabatrin (Sabril) in mild to moderate partial epilepsies. French Neurologists Sabril Study Group.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Epilepsies, Partial; Female; gamma-Aminobutyric Aci | 1997 |
High dose gabapentin in refractory partial epilepsy: clinical observations in 50 patients.
Topics: Acetates; Adolescent; Adult; Aged; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Diarrhea; D | 1998 |
Effects of gabapentin on cognition and quality of life in patients with epilepsy.
Topics: Acetates; Adult; Affect; Aged; Amines; Anticonvulsants; Cognition; Cyclohexanecarboxylic Acids; Epil | 1998 |
A double-blind trial of gabapentin monotherapy for newly diagnosed partial seizures. International Gabapentin Monotherapy Study Group 945-77.
Topics: Acetates; Adolescent; Adult; Aged; Aged, 80 and over; Amines; Anticonvulsants; Carbamazepine; Child; | 1998 |
Gabapentin add-on treatment: how many patients become seizure-free? An open-label multicenter study.
Topics: Acetates; Adolescent; Adult; Aged; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; F | 1999 |
Open comparative long-term study of vigabatrin vs carbamazepine in newly diagnosed partial seizures in children.
Topics: Administration, Oral; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsies, Partial; | 1999 |
Increased seizures after discontinuing carbamazepine: results from the gabapentin monotherapy trial.
Topics: Acetates; Adult; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Dose-Response | 2000 |
A controlled study of progabide in partial seizures: methodology and results.
Topics: Adolescent; Adult; Carbamazepine; Clinical Trials as Topic; Female; gamma-Aminobutyric Acid; Humans; | 1987 |
Effect of progabide on serum phenytoin and carbamazepine concentrations.
Topics: Adult; Carbamazepine; Convulsants; Double-Blind Method; Drug Evaluation; Female; gamma-Aminobutyric | 1987 |
1121 other studies available for gamma-aminobutyric acid and Seizures
| Article | Year |
|---|---|
Synthesis and anticonvulsant activity of 1-acyl-2-pyrrolidinone derivatives.
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry; gamma-Aminobutyric Acid; Male; Mice; Pyrrol | 1991 |
Stereoselective syntheses of the trans-decahydroquinoline-5-carboxylic acid epimers. Diastereomeric zwitterionic probes of gamma-aminobutyric acid related biological properties in vitro and in vivo.
Topics: Animals; Brain; Chemical Phenomena; Chemistry; Cyclic AMP; Diazepam; gamma-Aminobutyric Acid; Magnet | 1986 |
Studies on the anticonvulsant activity of 4-alkyl-1,2,4-triazole-3-thiones and their effect on GABAergic system.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Male; Mice; Molecular Stru | 2014 |
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Respo | 2017 |
Vasoactive intestinal peptide (VIP) conducts the neuronal activity during absence seizures: GABA seems to be the main mediator of VIP.
Topics: Animals; Epilepsy, Absence; Female; gamma-Aminobutyric Acid; Rats; Rats, Wistar; Seizures; Somatosen | 2021 |
OV329, a novel highly potent γ-aminobutyric acid aminotransferase inactivator, induces pronounced anticonvulsant effects in the pentylenetetrazole seizure threshold test and in amygdala-kindled rats.
Topics: Amygdala; Animals; Anticonvulsants; Epilepsy; Female; gamma-Aminobutyric Acid; Humans; Kindling, Neu | 2021 |
Gain-of-function variants in GABRD reveal a novel pathway for neurodevelopmental disorders and epilepsy.
Topics: Autism Spectrum Disorder; Epilepsy; Epilepsy, Generalized; GABA Plasma Membrane Transport Proteins; | 2022 |
O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 modulate seizure susceptibility in C. elegans.
Topics: Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Disease Susceptibility; GABAergic | 2021 |
GABA-cadabra: autoantibodies trick neurotransmitter receptors and induce seizures.
Topics: Autoantibodies; gamma-Aminobutyric Acid; Humans; Receptors, Neurotransmitter; Seizures | 2021 |
Human Stem Cell-Derived GABAergic Interneurons Establish Efferent Synapses onto Host Neurons in Rat Epileptic Hippocampus and Inhibit Spontaneous Recurrent Seizures.
Topics: Animals; Cells, Cultured; Disease Models, Animal; gamma-Aminobutyric Acid; Hippocampus; Humans; Inte | 2021 |
An epileptic encephalopathy associated GABRG2 missense mutation leads to pre- and postsynaptic defects in zebrafish.
Topics: Animals; Brain Diseases; gamma-Aminobutyric Acid; Humans; Mutation; Mutation, Missense; Receptors, G | 2022 |
An aqueous extract of Lantana camara attenuates seizures, memory impairment, and anxiety in kainate-treated mice: Evidence of GABA level, oxidative stress, immune and neuronal loss modulation.
Topics: Animals; Anxiety; Anxiety Disorders; gamma-Aminobutyric Acid; Humans; Kainic Acid; Lantana; Mice; Ox | 2022 |
The 5-HT7 receptor antagonist SB-269970 alleviates seizure activity and downregulates hippocampal c-Fos expression in pentylenetetrazole-induced kindled rats.
Topics: Animals; gamma-Aminobutyric Acid; Hippocampus; Kindling, Neurologic; Male; Pentylenetetrazole; Pheno | 2022 |
Cell-Selective Adeno-Associated Virus-Mediated
Topics: Animals; Dependovirus; Disease Models, Animal; Epilepsies, Myoclonic; Epileptic Syndromes; gamma-Ami | 2022 |
HAP1 interacts with 14-3-3 to regulate epileptic seizure via GABA
Topics: 14-3-3 Proteins; Animals; Epilepsy; gamma-Aminobutyric Acid; Nerve Tissue Proteins; Pentylenetetrazo | 2022 |
Astrocytic GABA transporter 1 deficit in novel SLC6A1 variants mediated epilepsy: Connected from protein destabilization to seizures in mice and humans.
Topics: Animals; Astrocytes; Epilepsies, Myoclonic; Epilepsy, Absence; GABA Plasma Membrane Transport Protei | 2022 |
Electrophysiological Evidence for Anti-epileptic Property of Taurine.
Topics: Amino Acids; Animals; Anticonvulsants; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Isoniazid; Ka | 2022 |
Putrescine Intensifies Glu/GABA Exchange Mechanism and Promotes Early Termination of Seizures.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; gamma-Aminobutyric Acid; P | 2022 |
Pronounced antiseizure activity of the subtype-selective GABA
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistant Epilepsy; Electroencephal | 2022 |
Pronounced antiseizure activity of the subtype-selective GABA
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistant Epilepsy; Electroencephal | 2022 |
Pronounced antiseizure activity of the subtype-selective GABA
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistant Epilepsy; Electroencephal | 2022 |
Pronounced antiseizure activity of the subtype-selective GABA
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistant Epilepsy; Electroencephal | 2022 |
Consequences: Bench to home.
Topics: Chlorides; Epilepsy, Generalized; gamma-Aminobutyric Acid; Humans; Quality of Life; Receptors, GABA- | 2022 |
Roundup and glyphosate's impact on GABA to elicit extended proconvulsant behavior in Caenorhabditis elegans.
Topics: Animals; Caenorhabditis elegans; gamma-Aminobutyric Acid; Glycine; Glyphosate; Herbicides; Humans; S | 2022 |
Lacosamide decreases neonatal seizures without increasing apoptosis.
Topics: Animals; Apoptosis; gamma-Aminobutyric Acid; Lacosamide; Mice; Mice, Inbred C57BL; Seizures | 2022 |
Stem bark chloroform extract of Bombax costatum Pellegr. & Vuillet exhibit anticonvulsant and neuroprotective effects in pentylenetetrazole-induced seizures in rats.
Topics: Animals; Anticonvulsants; Bombax; Chloroform; gamma-Aminobutyric Acid; Neuroprotective Agents; Penty | 2023 |
De novo Y1460C missense variant in Na
Topics: Action Potentials; Epilepsy; Epilepsy, Generalized; gamma-Aminobutyric Acid; HEK293 Cells; Humans; N | 2022 |
Cognitive and behavioral effects of the anti-epileptic drug cenobamate (YKP3089) and underlying synaptic and cellular mechanisms.
Topics: Animals; Cognition; gamma-Aminobutyric Acid; Mice; Seizures; Sodium; Synaptic Transmission | 2022 |
Promising anticonvulsant N-[(2,4-dichlorophenyl) methyl]-2-(2,4-dioxo-1H-quinazolin-3-yl) acetamide: dose-dependent study and evaluation of anticonvulsant action spectrum in vivo and in silico.
Topics: Acetamides; Action Spectrum; Animals; Anticonvulsants; Caffeine; gamma-Aminobutyric Acid; Mice; Mole | 2022 |
Promising anticonvulsant N-[(2,4-dichlorophenyl) methyl]-2-(2,4-dioxo-1H-quinazolin-3-yl) acetamide: dose-dependent study and evaluation of anticonvulsant action spectrum in vivo and in silico.
Topics: Acetamides; Action Spectrum; Animals; Anticonvulsants; Caffeine; gamma-Aminobutyric Acid; Mice; Mole | 2022 |
Promising anticonvulsant N-[(2,4-dichlorophenyl) methyl]-2-(2,4-dioxo-1H-quinazolin-3-yl) acetamide: dose-dependent study and evaluation of anticonvulsant action spectrum in vivo and in silico.
Topics: Acetamides; Action Spectrum; Animals; Anticonvulsants; Caffeine; gamma-Aminobutyric Acid; Mice; Mole | 2022 |
Promising anticonvulsant N-[(2,4-dichlorophenyl) methyl]-2-(2,4-dioxo-1H-quinazolin-3-yl) acetamide: dose-dependent study and evaluation of anticonvulsant action spectrum in vivo and in silico.
Topics: Acetamides; Action Spectrum; Animals; Anticonvulsants; Caffeine; gamma-Aminobutyric Acid; Mice; Mole | 2022 |
Clptm1, a new target in suppressing epileptic seizure by regulating GABA
Topics: Animals; Cleft Lip; Cleft Palate; Epilepsy; gamma-Aminobutyric Acid; Membrane Proteins; Pentylenetet | 2023 |
Clptm1, a new target in suppressing epileptic seizure by regulating GABA
Topics: Animals; Cleft Lip; Cleft Palate; Epilepsy; gamma-Aminobutyric Acid; Membrane Proteins; Pentylenetet | 2023 |
Clptm1, a new target in suppressing epileptic seizure by regulating GABA
Topics: Animals; Cleft Lip; Cleft Palate; Epilepsy; gamma-Aminobutyric Acid; Membrane Proteins; Pentylenetet | 2023 |
Clptm1, a new target in suppressing epileptic seizure by regulating GABA
Topics: Animals; Cleft Lip; Cleft Palate; Epilepsy; gamma-Aminobutyric Acid; Membrane Proteins; Pentylenetet | 2023 |
Altered GABA
Topics: Animals; Disease Models, Animal; Epilepsy, Absence; gamma-Aminobutyric Acid; Mice; Receptors, GABA-A | 2022 |
Genetic interaction between GABRA1 and ERBB4 variants in the pathogenesis of genetic generalized epilepsy.
Topics: Epilepsy; Epilepsy, Generalized; Family; gamma-Aminobutyric Acid; Humans; Receptor, ErbB-4; Receptor | 2023 |
Developmental Inhibitory Changes in the Primary Somatosensory Cortex of the Stargazer Mouse Model of Absence Epilepsy.
Topics: Animals; Epilepsy, Absence; gamma-Aminobutyric Acid; Mice; Receptors, GABA-A; Seizures; Somatosensor | 2023 |
LINCs Are Vulnerable to Epileptic Insult and Fail to Provide Seizure Control via On-Demand Activation.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Female; gamma-Aminobutyric Acid; | 2023 |
Progressive tremor and motor impairment in seizure-prone mutant tremor mice are associated with neurotransmitter dysfunction.
Topics: Animals; Aspartic Acid; Corpus Striatum; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; | 2023 |
Role of long noncoding RNAs; BDNF-AS and 17A and their relation to GABAergic dysfunction in Egyptian epileptic patients.
Topics: Brain-Derived Neurotrophic Factor; Egypt; Epilepsies, Partial; Epilepsy; gamma-Aminobutyric Acid; Gl | 2023 |
The presence and severity of epilepsy coincide with reduced γ-aminobutyrate and cortical excitatory markers in succinic semialdehyde dehydrogenase deficiency.
Topics: Amino Acid Metabolism, Inborn Errors; Aminobutyrates; Child; Developmental Disabilities; Epilepsy; g | 2023 |
Fingolimod Administration Following Hypoxia Induced Neonatal Seizure Can Restore Impaired Long-term Potentiation and Memory Performance in Adult Rats.
Topics: Animals; Epilepsy; Female; Fingolimod Hydrochloride; gamma-Aminobutyric Acid; Hippocampus; Hypoxia; | 2023 |
Effects of a ketogenic and low-fat diet on the human metabolome, microbiome, and foodome in adults at risk for Alzheimer's disease.
Topics: Adult; Alzheimer Disease; Diet, Fat-Restricted; gamma-Aminobutyric Acid; Humans; Ketone Bodies; Meta | 2023 |
Developmental and epileptic encephalopathy 89: A novel bi-allelic variant, molecular dynamics simulation, and a comprehensive clinical and molecular profile.
Topics: Adult; Cleft Palate; Epilepsy; Epilepsy, Generalized; gamma-Aminobutyric Acid; Humans; Molecular Doc | 2023 |
GABA
Topics: Animals; Binding Sites; gamma-Aminobutyric Acid; Receptors, GABA-A; Seizures; Zebrafish | 2023 |
Ameliorative effects of Albizia adianthifolia aqueous extract against pentylenetetrazole-induced epilepsy and associated memory loss in mice: Role of GABAergic, antioxidant defense and anti-inflammatory systems.
Topics: Albizzia; Amnesia; Animals; Anti-Inflammatory Agents; Anticonvulsants; Antioxidants; Epilepsy; gamma | 2023 |
Anticonvulsant potential of Grewia tiliaefolia in pentylenetetrazole induced epilepsy: insights from in vivo and in silico studies.
Topics: Animals; Anticonvulsants; Antioxidants; Chloroform; Epilepsy; Gallic Acid; gamma-Aminobutyric Acid; | 2023 |
The Aqueous Lyophilisate of Alchemilla Kiwuensis Engl. (Rosaceae) Displays Antiepileptogenic and Antiepileptic Effects on PTZ-induced Kindling in rats: Evidence of Modulation of Glutamatergic and GABAergic Pathways Coupled to Antioxidant Properties.
Topics: Alchemilla; Animals; Anticonvulsants; Antioxidants; Catalase; Epilepsy; Female; gamma-Aminobutyric A | 2023 |
SLC4A10 mutation causes a neurological disorder associated with impaired GABAergic transmission.
Topics: Animals; Child; Chloride-Bicarbonate Antiporters; gamma-Aminobutyric Acid; Humans; Mammals; Mice; Mu | 2023 |
Maternal hyperhomocysteinemia increases seizures susceptibility of neonatal rats.
Topics: Animals; Animals, Newborn; Epilepsy; Female; Flurothyl; gamma-Aminobutyric Acid; Hippocampus; Hyperh | 2023 |
Effects of probiotics on GABA/glutamate and oxidative stress in PTZ- induced acute seizure model in rats.
Topics: Animals; Anticonvulsants; Epilepsy; gamma-Aminobutyric Acid; Glutamic Acid; Male; Oxidative Stress; | 2023 |
Flumazenil Pretreatment Reduces Mefenamic Acid-Induced Central Nervous System Toxicity in Mice.
Topics: Animals; Behavior, Animal; Catalepsy; Central Nervous System; Flumazenil; gamma-Aminobutyric Acid; M | 2023 |
Herb pair of Polygala tenuifolia Willd and Acorus tatarinowii Schott decoction attenuates seizures and alleviates anxiety in mice: Evidence for modulating inflammation, alleviating oxidative stress and mediating GABA pathway.
Topics: Acorus; Animals; Anticonvulsants; Anxiety; Epilepsy; gamma-Aminobutyric Acid; Inflammation; Mice; Ox | 2023 |
E2730, an uncompetitive γ-aminobutyric acid transporter-1 inhibitor, suppresses epileptic seizures in a rat model of chronic mesial temporal lobe epilepsy.
Topics: Adult; Animals; Disease Models, Animal; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; g | 2023 |
Cenobamate and Clobazam Combination as Personalized Medicine in Autoimmune-Associated Epilepsy With Anti-Gad65 Antibodies.
Topics: Clobazam; Drug Resistant Epilepsy; Epilepsy; gamma-Aminobutyric Acid; Humans; Precision Medicine; Pr | 2023 |
Neuroplastin exerts antiepileptic effects through binding to the α1 subunit of GABA type A receptors to inhibit the internalization of the receptors.
Topics: Anticonvulsants; Carrier Proteins; gamma-Aminobutyric Acid; Humans; Neurons; Receptors, GABA-A; Seiz | 2023 |
MPMT-OX up-regulates GABAergic transmission and protects against seizure-like behavior in Caenorhabditis elegans.
Topics: Animals; Behavior, Animal; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Electrophysiolog | 2019 |
SIRT3 Haploinsufficiency Aggravates Loss of GABAergic Interneurons and Neuronal Network Hyperexcitability in an Alzheimer's Disease Model.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cerebral Cortex; Diet, Ketogenic; Electr | 2020 |
Bestrophin1-mediated tonic GABA release from reactive astrocytes prevents the development of seizure-prone network in kainate-injected hippocampi.
Topics: Animals; Astrocytes; Bestrophins; gamma-Aminobutyric Acid; Hippocampus; Kainic Acid; Mice; Mice, Kno | 2020 |
Anticonvulsant Activity of Essential Oil From Leaves of Zhumeria majdae (Rech.) in Mice: The Role of GABA
Topics: Animals; Anticonvulsants; Arginine; Diazepam; Disease Models, Animal; Dose-Response Relationship, Dr | 2020 |
Long-term vigabatrin treatment modifies pentylenetetrazole-induced seizures in mice: focused on GABA brain concentration.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Brain; Clonazepam; Disease Models, Animal; D | 2020 |
Experimentally Induced Convulsive Seizures Are Modulated in Part by Zinc Ions through the Pharmacoresistant Ca
Topics: Animals; Calcium Channels, R-Type; Cation Transport Proteins; Electroencephalography; gamma-Aminobut | 2020 |
Recurrent seizures cause immature brain injury and changes in GABA a receptor α1 and γ2 subunits.
Topics: Animals; Brain; Brain Injuries; Epilepsy, Generalized; Female; Flurothyl; gamma-Aminobutyric Acid; H | 2020 |
Topics: Amino Acid Sequence; Animals; Calcium-Binding Proteins; gamma-Aminobutyric Acid; Gene Expression Pro | 2020 |
Neurobiology: Crowdsourcing CO
Topics: Animals; Brain; Carbon Dioxide; Crowdsourcing; gamma-Aminobutyric Acid; Masks; Mole Rats; Neurobiolo | 2020 |
Increase in Seizure Susceptibility After Repetitive Concussion Results from Oxidative Stress, Parvalbumin-Positive Interneuron Dysfunction and Biphasic Increases in Glutamate/GABA Ratio.
Topics: Animals; Brain; Brain Concussion; Gamma Rhythm; gamma-Aminobutyric Acid; Glutamic Acid; Interneurons | 2020 |
Commentary and Update on the Contribution of the GABA Hypothesis to Understanding the Mechanism of Action of Electroconvulsive Therapy.
Topics: Animals; Brain; Brain Chemistry; Depressive Disorder, Major; Electroconvulsive Therapy; gamma-Aminob | 2021 |
Syntaxin 1B regulates synaptic GABA release and extracellular GABA concentration, and is associated with temperature-dependent seizures.
Topics: Animals; Animals, Newborn; Body Temperature; Cells, Cultured; Extracellular Fluid; gamma-Aminobutyri | 2021 |
A Missense Variant in
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acid Sequence; Animals; Brain; Cerebrospinal Fluid; Deve | 2020 |
Impaired State-Dependent Potentiation of GABAergic Synaptic Currents Triggers Seizures in a Genetic Generalized Epilepsy Model.
Topics: Action Potentials; Animals; Electroencephalography; Electrophysiological Phenomena; Epilepsy, Genera | 2021 |
Preclinical characterization of zuranolone (SAGE-217), a selective neuroactive steroid GABA
Topics: Animals; Anticonvulsants; Antidepressive Agents; Binding Sites; Brain; Diazepam; Drug Synergism; Ele | 2020 |
The γ-Protocadherins Regulate the Survival of GABAergic Interneurons during Developmental Cell Death.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cadherin Related Proteins; Cadherins; Cell Death; Ce | 2020 |
PHF24 is expressed in the inhibitory interneurons in rats.
Topics: Animals; Calbindin 2; Calbindins; Central Nervous System; Disease Models, Animal; gamma-Aminobutyric | 2021 |
Electrophysiological field potential identification of an intact GABAergic system in mouse cortical slices.
Topics: Action Potentials; Animals; Brain; Electrophysiological Phenomena; gamma-Aminobutyric Acid; Mice, In | 2021 |
Neurochemical Effects of 4-(2Chloro-4-Fluorobenzyl)-3-(2-Thienyl)-1,2,4-Oxadiazol-5(4H)-One in the Pentylenetetrazole (PTZ)-Induced Epileptic Seizure Zebrafish Model.
Topics: Animals; Anticonvulsants; Antioxidants; Brain; Brain Chemistry; Dihydrotestosterone; Disease Models, | 2021 |
Dysregulation of REV-ERBα impairs GABAergic function and promotes epileptic seizures in preclinical models.
Topics: Acute Disease; Animals; Basic-Leucine Zipper Transcription Factors; Chronic Disease; Disease Models, | 2021 |
A critical period of neuronal activity results in aberrant neurogenesis rewiring hippocampal circuitry in a mouse model of epilepsy.
Topics: Animals; Calcium; Clozapine; Disease Models, Animal; Electroencephalography; Epilepsy; Epilepsy, Tem | 2021 |
Chronic loss of inhibition in piriform cortex following brief, daily optogenetic stimulation.
Topics: Animals; Electric Stimulation; Electrodes, Implanted; Evoked Potentials; Feedback, Physiological; Fe | 2021 |
Neurodevelopmental phenotypes associated with pathogenic variants in
Topics: Autism Spectrum Disorder; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Humans; | 2022 |
Metabolomic signature of the Dravet syndrome: A genetic mouse model study.
Topics: Animals; Bile Acids and Salts; Disease Models, Animal; Epilepsies, Myoclonic; Epileptic Syndromes; g | 2021 |
TRESK channel contributes to depolarization-induced shunting inhibition and modulates epileptic seizures.
Topics: Action Potentials; Animals; Calcium; gamma-Aminobutyric Acid; Gene Expression Regulation; HEK293 Cel | 2021 |
Neurochemical abnormalities in the hippocampus of male rats displaying audiogenic seizures, a genetic model of epilepsy.
Topics: Animals; Calcium; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Neuronal Calcium-Sensor | 2021 |
Impact of Dysfunctional Feed-Forward Inhibition on Glutamate Decarboxylase Isoforms and γ-Aminobutyric Acid Transporters.
Topics: Animals; Disease Models, Animal; Epilepsy, Absence; Female; gamma-Aminobutyric Acid; Glutamate Decar | 2021 |
Anti-seizure effects of walnut peptides in mouse models of induced seizure: The involvement of GABA and nitric oxide pathways.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; gamma-Aminobutyr | 2021 |
Anticonvulsant activity and acute neurotoxic profile of Achyranthes aspera Linn.
Topics: Achyranthes; Animals; Anticonvulsants; Cerebral Cortex; Electroshock; gamma-Aminobutyric Acid; Hippo | 2017 |
Ameliorative potential of Colebrookea oppositifolia methanolic root extract against experimental models of epilepsy: Possible role of GABA mediated mechanism.
Topics: Animals; Anticonvulsants; Brain; Electroshock; Epilepsy; gamma-Aminobutyric Acid; Lamiaceae; Medicin | 2017 |
Combination therapy of levetiracetam and gabapentin against nonconvulsive seizures induced by penetrating traumatic brain injury.
Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Drug Therapy, Combin | 2017 |
Anticonvulsant profile of the neuroactive steroid, SGE-516, in animal models.
Topics: Action Potentials; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Electroshock; Frag | 2017 |
Pregabalin and heart failure: A population-based study.
Topics: Aged; Aged, 80 and over; Amines; Anticonvulsants; Calcium Channel Blockers; Cohort Studies; Cyclohex | 2017 |
Depolarized GABAergic Signaling in Subicular Microcircuits Mediates Generalized Seizure in Temporal Lobe Epilepsy.
Topics: Adolescent; Adult; Animals; Case-Control Studies; Disease Models, Animal; Electroencephalography; Ep | 2017 |
Effects of ERK1/2 kinases inactivation on the nigrostriatal system of Krushinsky-Molodkina rats genetically prone to audiogenic seizures.
Topics: Acoustic Stimulation; Aminoacetonitrile; Animals; Auditory Perception; Corpus Striatum; Disease Mode | 2017 |
Neuropharmacological and neuroprotective activities of some metabolites produced by cell suspension culture of Waltheria americana Linn.
Topics: Animals; Anticonvulsants; Biomass; Cerebral Cortex; Female; gamma-Aminobutyric Acid; Glial Fibrillar | 2017 |
Evidence for the involvement of the GABA-ergic pathway in the anticonvulsant activity of the roots bark aqueous extract of Anthocleista djalonensis A. Chev. (Loganiaceae).
Topics: Animals; Anticonvulsants; Benzodiazepines; gamma-Aminobutyric Acid; Loganiaceae; Male; Mice; Mice, I | 2017 |
A species dependent response to the pro-epileptic drug pentylentetrazole in birds.
Topics: Animals; Convulsants; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamic Acid; Immu | 2017 |
Suppression of cortical seizures by optic stimulation of the reticular thalamus in PV-mhChR2-YFP BAC transgenic mice.
Topics: Animals; Bacterial Proteins; Cerebral Cortex; Channelrhodopsins; Chromosomes, Artificial, Bacterial; | 2017 |
Effects of gut microbiota disturbance induced in early life on the expression of extrasynaptic GABA-A receptor α5 and δ subunits in the hippocampus of adult rats.
Topics: Animals; Behavior, Animal; Brain; gamma-Aminobutyric Acid; Gastrointestinal Microbiome; Hippocampus; | 2017 |
Pyridoxine-Dependent Epilepsy in Zebrafish Caused by Aldh7a1 Deficiency.
Topics: Aldehyde Dehydrogenase; Animals; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Gene Kno | 2017 |
Calcitonin potentiates the anticonvulsant and antinociceptive effects of valproic acid and pregabalin in pentylenetetrazole-kindled mice.
Topics: Analgesics; Animals; Anticonvulsants; Brain; Calcitonin; Drug Synergism; gamma-Aminobutyric Acid; Mi | 2018 |
Gamma-aminobutyric acid-B limbic encephalitis and asystolic cardiac arrest: a case report.
Topics: Accidents, Traffic; Aged; Antineoplastic Agents; Autoimmune Diseases; gamma-Aminobutyric Acid; Heart | 2017 |
Neuromuscular features of hypophosphatasia.
Topics: Adult; Alkaline Phosphatase; Animals; Biomarkers; Brain Diseases; Chronic Pain; Disease Models, Anim | 2017 |
Developmental changes of GABA immunoreactivity in cortico-thalamic networks of an absence seizure model.
Topics: Animals; Cerebral Cortex; Disease Models, Animal; Epilepsy, Absence; GABAergic Neurons; gamma-Aminob | 2018 |
The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet.
Topics: Animals; Anti-Bacterial Agents; Bacteroides; Diet, Ketogenic; Disease Models, Animal; Feces; gamma-A | 2018 |
The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet.
Topics: Animals; Anti-Bacterial Agents; Bacteroides; Diet, Ketogenic; Disease Models, Animal; Feces; gamma-A | 2018 |
The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet.
Topics: Animals; Anti-Bacterial Agents; Bacteroides; Diet, Ketogenic; Disease Models, Animal; Feces; gamma-A | 2018 |
The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet.
Topics: Animals; Anti-Bacterial Agents; Bacteroides; Diet, Ketogenic; Disease Models, Animal; Feces; gamma-A | 2018 |
The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet.
Topics: Animals; Anti-Bacterial Agents; Bacteroides; Diet, Ketogenic; Disease Models, Animal; Feces; gamma-A | 2018 |
The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet.
Topics: Animals; Anti-Bacterial Agents; Bacteroides; Diet, Ketogenic; Disease Models, Animal; Feces; gamma-A | 2018 |
The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet.
Topics: Animals; Anti-Bacterial Agents; Bacteroides; Diet, Ketogenic; Disease Models, Animal; Feces; gamma-A | 2018 |
The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet.
Topics: Animals; Anti-Bacterial Agents; Bacteroides; Diet, Ketogenic; Disease Models, Animal; Feces; gamma-A | 2018 |
The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet.
Topics: Animals; Anti-Bacterial Agents; Bacteroides; Diet, Ketogenic; Disease Models, Animal; Feces; gamma-A | 2018 |
Anticonvulsant effect of dipropofol by enhancing native GABA currents in cortical neurons in mice.
Topics: Alkanes; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Entorhinal Cortex; gamma-Aminob | 2018 |
Remodeled cortical inhibition prevents motor seizures in generalized epilepsy.
Topics: Animals; Cerebral Cortex; Epilepsy, Generalized; GABAergic Neurons; gamma-Aminobutyric Acid; Interne | 2018 |
Electrophoretic drug delivery for seizure control.
Topics: Animals; Drug Delivery Systems; GABA Agents; gamma-Aminobutyric Acid; Mice; Microfluidics; Seizures | 2018 |
Gut Microbes May Account for the Anti-Seizure Effects of the Ketogenic Diet.
Topics: Animals; Bacteroidetes; Diet, Ketogenic; Disease Models, Animal; gamma-Aminobutyric Acid; Gastrointe | 2018 |
Cortical excitability and seizure control influence attention performance in patients with idiopathic generalized epilepsies (IGEs).
Topics: Adult; Analysis of Variance; Attention; Case-Control Studies; Cognition; Cortical Excitability; Epil | 2018 |
Design, synthesis, and molecular docking study of benzothiazolotriazine derivatives for anticonvulsant potential.
Topics: Animals; Anticonvulsants; Benzothiazoles; Binding Sites; Disease Models, Animal; Dose-Response Relat | 2018 |
Inhibitory Thoracic Interneurons are not Essential to Generate the Rostro-caudal Gradient of the Thoracic Inspiratory Motor Activity in Neonatal Rat.
Topics: Animals; Animals, Newborn; Brain Stem; gamma-Aminobutyric Acid; Glycine; Inhalation; Interneurons; M | 2019 |
Transplanting GABAergic Neurons Differentiated from Neural Stem Cells into Hippocampus Inhibits Seizures and Epileptiform Discharges in Pilocarpine-Induced Temporal Lobe Epilepsy Model.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Drug Resistant Epilepsy; Electroencephalography; | 2019 |
Recording of Neural Activity With Modulation of Photolysis of Caged Compounds Using Microelectrode Arrays in Rats With Seizures.
Topics: Action Potentials; Animals; Electrophysiology; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; | 2019 |
Effect of newer anti-epileptic drugs (AEDs) on the cognitive status in pentylenetetrazol induced seizures in a zebrafish model.
Topics: Acetylcholine; Animals; Anticonvulsants; Brain; Brain-Derived Neurotrophic Factor; Cognitive Dysfunc | 2019 |
Delayed maturation of GABAergic signaling in the Scn1a and Scn1b mouse models of Dravet Syndrome.
Topics: Animals; Bumetanide; Death, Sudden; Disease Models, Animal; Epilepsies, Myoclonic; Epilepsy; gamma-A | 2019 |
The expanded clinical spectrum of anti-GABABR encephalitis and added value of KCTD16 autoantibodies.
Topics: Adult; Aged; Aged, 80 and over; Autoantibodies; Encephalitis; Female; gamma-Aminobutyric Acid; Human | 2019 |
The Anticonvulsant Effects of Baldrinal on Pilocarpine-Induced convulsion in Adult Male Mice.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Glutamic | 2019 |
Long-lasting disruption of spatial memory by GABA
Topics: Animals; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; Male; Maze Learning; Mem | 2019 |
Gluconate suppresses seizure activity in developing brains by inhibiting CLC-3 chloride channels.
Topics: Animals; Animals, Newborn; Brain; Cells, Cultured; Chloride Channels; Chlorides; Down-Regulation; ga | 2019 |
Role of microRNA-155 in modifying neuroinflammation and γ-aminobutyric acid transporters in specific central regions after post-ischaemic seizures.
Topics: Amygdala; Animals; Brain Ischemia; Disease Models, Animal; Epilepsy; GABA Plasma Membrane Transport | 2019 |
Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice.
Topics: 4-Aminopyridine; Animals; Brain; Craniotomy; Disease Models, Animal; Electrophoresis; Epilepsy; gamm | 2019 |
Long-lasting changes in hippocampal GABA
Topics: Amygdala; Animals; Excitatory Postsynaptic Potentials; Female; GABA-B Receptor Antagonists; gamma-Am | 2019 |
Role of nitric oxide synthase on brain GABA transaminase activity and GABA levels.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Brain; Disease Models, Animal; gamma-Aminobu | 2018 |
KCC2 Regulates Neuronal Excitability and Hippocampal Activity via Interaction with Task-3 Channels.
Topics: Animals; Dentate Gyrus; Evoked Potentials; GABA Antagonists; gamma-Aminobutyric Acid; Gene Knockdown | 2019 |
A genetically encoded fluorescent sensor for in vivo imaging of GABA.
Topics: Anesthesia; Animals; Animals, Genetically Modified; Biosensing Techniques; Brain; Female; gamma-Amin | 2019 |
The effect of exercise on GABA signaling pathway in the model of chemically induced seizures.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Gene Expression; Glutamate Decarboxylase; | 2019 |
Presynaptic Endosomal Cathepsin D Regulates the Biogenesis of GABAergic Synaptic Vesicles.
Topics: Adolescent; Aged; Animals; Cathepsin D; Disease Susceptibility; Endocytosis; Endosomes; gamma-Aminob | 2019 |
Synergistic GABA-enhancing therapy against seizures in a mouse model of Dravet syndrome.
Topics: Animals; Anticonvulsants; Clonazepam; Dose-Response Relationship, Drug; Drug Synergism; Epilepsies, | 2013 |
Vigabatrin inhibits seizures and mTOR pathway activation in a mouse model of tuberous sclerosis complex.
Topics: Animals; Anticonvulsants; Astrocytes; Brain; Cell Proliferation; Cells, Cultured; Disease Models, An | 2013 |
Oral gabapentin suppresses pentylenetetrazole-induced seizure-like behavior and cephalic field potential in adult zebrafish.
Topics: Action Potentials; Administration, Oral; Amines; Analysis of Variance; Animals; Anticonvulsants; Bra | 2013 |
Combined treatment with gabapentin and drugs affecting the renin-angiotensin system against electroconvulsions in mice.
Topics: Amines; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; | 2013 |
Synthesis and anticonvulsant activity evaluation of 4-(2-alkoxy-phenyl)-2,4-dihydro-3H-1,2,4-triazol-3-ones in various experimental seizure models in mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; gamma-Aminobutyric Acid; Mice; Seizures; Triazoles | 2013 |
Anticonvulsant activity of 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose isolated from leaves of Mangifera indica.
Topics: Animals; Anticonvulsants; Brain; Electroshock; gamma-Aminobutyric Acid; Hydrolyzable Tannins; Male; | 2013 |
Antiepileptic activity of lobeline isolated from the leaf of Lobelia nicotianaefolia and its effect on brain GABA level in mice.
Topics: Animals; Anticonvulsants; Brain; Brain Chemistry; Convulsants; Disease Models, Animal; gamma-Aminobu | 2012 |
CaV 2.1 ablation in cortical interneurons selectively impairs fast-spiking basket cells and causes generalized seizures.
Topics: Animals; Calcium Channels, N-Type; Cerebral Cortex; gamma-Aminobutyric Acid; Interneurons; Mice; Mic | 2013 |
Regulation of epileptiform activity by two distinct subtypes of extrasynaptic GABAA receptors.
Topics: Animals; Benzothiadiazines; Cells, Cultured; Epilepsy; Female; gamma-Aminobutyric Acid; HEK293 Cells | 2013 |
[Comparison of neuroprotective effects of anticonvulsant drugs in brain injury therapy].
Topics: Amines; Animals; Animals, Outbred Strains; Anticonvulsants; Brain; Brain Injuries; Brain Ischemia; C | 2012 |
Pregabalin attenuates excitotoxicity in diabetes.
Topics: Adenosine Triphosphate; Animals; Anticonvulsants; Blood Glucose; Cell Line; Diabetic Neuropathies; D | 2013 |
Cyclopropane-based conformational restriction of GABA by a stereochemical diversity-oriented strategy: identification of an efficient lead for potent inhibitors of GABA transports.
Topics: Animals; Anticonvulsants; Brain; Cyclopropanes; GABA Modulators; GABA Plasma Membrane Transport Prot | 2013 |
The anticonvulsant and sedative effects of Gladiolus dalenii extracts in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Brain; Diazepam; Disease Models, Animal; Dose-Respon | 2013 |
Anticonvulsant activity of Hypericum scabrum L.; possible mechanism involved.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Free Radical Sca | 2013 |
Anticonvulsant activity of fraction isolated from ethanolic extract of heartwood of Cedrus deodara.
Topics: Animals; Anticonvulsants; Brain; Cedrus; Ethanol; Female; gamma-Aminobutyric Acid; Male; Mice; Plant | 2014 |
Bombesin facilitates GABAergic transmission and depresses epileptiform activity in the entorhinal cortex.
Topics: Action Potentials; Animals; Anticonvulsants; Bombesin; Entorhinal Cortex; Epilepsy; gamma-Aminobutyr | 2014 |
Mechanisms of seizure propagation in 2-dimensional centre-surround recurrent networks.
Topics: Algorithms; Brain; Electroencephalography; Epilepsy; Extracellular Space; GABA Antagonists; gamma-Am | 2013 |
Electrographic seizures are significantly reduced by in vivo inhibition of neuronal uptake of extracellular glutamine in rat hippocampus.
Topics: Amino Acid Transport System A; Amino Acid Transport Systems; Aminoisobutyric Acids; Animals; gamma-A | 2013 |
Design of benzothiazole-1,3,4-thiadiazole conjugates: synthesis and anticonvulsant evaluation.
Topics: Animals; Anticonvulsants; Benzothiazoles; Brain; Disease Models, Animal; Drug Design; Electroshock; | 2013 |
Effects of WIN 55,212-2 mesylate on the anticonvulsant action of lamotrigine, oxcarbazepine, pregabalin and topiramate against maximal electroshock-induced seizures in mice.
Topics: Animals; Anticonvulsants; Avoidance Learning; Benzoxazines; Brain; Cannabinoid Receptor Agonists; Ca | 2013 |
Synaptic plasticity in glutamatergic and GABAergic neurotransmission following chronic memantine treatment in an in vitro model of limbic epileptogenesis.
Topics: Animals; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Mem | 2014 |
Gabapentin administration reduces reactive gliosis and neurodegeneration after pilocarpine-induced status epilepticus.
Topics: Amines; Animals; Astrocytes; Cyclohexanecarboxylic Acids; Electroencephalography; Gabapentin; gamma- | 2013 |
Antiepileptic potential of matrine via regulation the levels of gamma-aminobutyric acid and glutamic acid in the brain.
Topics: Alkaloids; Animals; Anticonvulsants; Aspartic Acid; Brain; gamma-Aminobutyric Acid; Glutamate Decarb | 2013 |
Epoxy fatty acids and inhibition of the soluble epoxide hydrolase selectively modulate GABA mediated neurotransmission to delay onset of seizures.
Topics: Animals; Eicosanoids; Epoxide Hydrolases; gamma-Aminobutyric Acid; Male; Mice; Seizures; Synaptic Tr | 2013 |
Alteration of striatal dopamine levels under various partial pressure of oxygen in pre-convulsive and convulsive phases in freely-moving rats.
Topics: Animals; Corpus Striatum; Dopamine; Electrodes; gamma-Aminobutyric Acid; Glutamic Acid; Hyperbaric O | 2014 |
Seizure-induced alterations in fast-spiking basket cell GABA currents modulate frequency and coherence of gamma oscillation in network simulations.
Topics: Biological Clocks; Brain Waves; Computer Simulation; Dendrites; gamma-Aminobutyric Acid; Humans; Mod | 2013 |
Synthesis and anticonvulsant activity evaluation of 7-alkoxy[1,2,4]triazolo[3,4-b]benzothiazol-3(2H)-ones.
Topics: Administration, Oral; Animals; Anticonvulsants; Disease Models, Animal; Electroshock; gamma-Aminobut | 2014 |
Loss of MeCP2 from forebrain excitatory neurons leads to cortical hyperexcitation and seizures.
Topics: Animals; Electroencephalography; gamma-Aminobutyric Acid; Immunohistochemistry; Male; Methyl-CpG-Bin | 2014 |
The anticonvulsant effects of SR 57227 on pentylenetetrazole-induced seizure in mice.
Topics: Animals; Anticonvulsants; gamma-Aminobutyric Acid; Hippocampus; Male; Mice, Inbred ICR; Ondansetron; | 2014 |
Anticonvulsant activity of pregabalin in the maximal electroshock-induced seizure assay in α2δ1 (R217A) and α2δ2 (R279A) mouse mutants.
Topics: Animals; Anticonvulsants; Calcium Channels; Disease Models, Animal; Dose-Response Relationship, Drug | 2014 |
Downregulated GABA and BDNF-TrkB pathway in chronic cyclothiazide seizure model.
Topics: 4-Aminobutyrate Transaminase; Animals; Behavior, Animal; Benzothiadiazines; Brain-Derived Neurotroph | 2014 |
Metalloproteinase inhibition prevents inhibitory synapse reorganization and seizure genesis.
Topics: Animals; Calbindin 2; Calbindins; Disease Models, Animal; Doxycycline; Extracellular Matrix; gamma-A | 2014 |
Asynchronous GABA Release Is a Key Determinant of Tonic Inhibition and Controls Neuronal Excitability: A Study in the Synapsin II-/- Mouse.
Topics: Action Potentials; Animals; Excitatory Postsynaptic Potentials; GABA Agonists; gamma-Aminobutyric Ac | 2015 |
Synthesis, biological evaluation and structure-activity relationship of new GABA uptake inhibitors, derivatives of 4-aminobutanamides.
Topics: Analgesics; Animals; Anticonvulsants; Antidepressive Agents; Chemistry Techniques, Synthetic; GABA U | 2014 |
Albumin nanoparticles for the delivery of gabapentin: preparation, characterization and pharmacodynamic studies.
Topics: Amines; Animals; Anticonvulsants; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Drug C | 2014 |
Effects of intravenous human umbilical cord blood mesenchymal stem cell therapy versus gabapentin in pentylenetetrazole-induced chronic epilepsy in rats.
Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Epilepsy; Female; Gabapentin; | 2014 |
Population pharmacokinetics analysis of vigabatrin in adults and children with epilepsy and children with infantile spasms.
Topics: Adult; Body Weight; Child; Child, Preschool; Enzyme Inhibitors; Epilepsy; Female; gamma-Aminobutyric | 2014 |
Effect of spontaneous seizures on GABAA receptor α4 subunit expression in an animal model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Pilocarpine; Rats | 2014 |
A novel mutation of ALDH5A1 gene associated with succinic semialdehyde dehydrogenase deficiency.
Topics: Amino Acid Metabolism, Inborn Errors; Brain; Developmental Disabilities; Diagnosis, Differential; ga | 2015 |
Persistent reduction of hippocampal glutamine synthetase expression after status epilepticus in immature rats.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Glutamate | 2014 |
Why glioma patients seize: adding more pathological GABA to the glutamate hypothesis.
Topics: Animals; Brain Neoplasms; gamma-Aminobutyric Acid; Glioma; Glutamic Acid; Humans; Seizures | 2014 |
Prosaposin overexpression following kainic acid-induced neurotoxicity.
Topics: Animals; Cerebral Cortex; Choroid Plexus; GABAergic Neurons; gamma-Aminobutyric Acid; Gene Expressio | 2014 |
Atorvastatin prevents development of kindling by modulating hippocampal levels of dopamine, glutamate, and GABA in mice.
Topics: Animals; Anticonvulsants; Atorvastatin; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Heptanoic | 2015 |
Chronic stress shifts the GABA reversal potential in the hippocampus and increases seizure susceptibility.
Topics: Acute Disease; Animals; Bumetanide; Chronic Disease; Corticosterone; Disease Models, Animal; gamma-A | 2015 |
Effects of eslicarbazepine acetate on acute and chronic latrunculin A-induced seizures and extracellular amino acid levels in the mouse hippocampus.
Topics: Acute Disease; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Bridged Bicyclo Compounds, Hete | 2014 |
Interneuron activity leads to initiation of low-voltage fast-onset seizures.
Topics: 4-Aminopyridine; Animals; Electrophysiological Phenomena; Entorhinal Cortex; GABAergic Neurons; gamm | 2015 |
Hippocampal orexin receptors inactivation reduces PTZ induced seizures of male rats.
Topics: Animals; Benzoxazoles; Convulsants; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Isoquinolin | 2015 |
On the contribution of KCC2 and carbonic anhydrase to two types of in vitro interictal discharge.
Topics: Acetazolamide; Animals; CA3 Region, Hippocampal; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; | 2015 |
Functional and structural deficits of the dentate gyrus network coincide with emerging spontaneous seizures in an Scn1a mutant Dravet Syndrome model during development.
Topics: Action Potentials; Age Factors; Animals; Animals, Newborn; Dentate Gyrus; Disease Models, Animal; Ep | 2015 |
Anticonvulsant and Sedative Effects of Eudesmin isolated from Acorus tatarinowii on mice and rats.
Topics: Acorus; Animals; Anticonvulsants; Brain; Caspase 3; Disease Models, Animal; Electroshock; Epilepsy; | 2015 |
Alterations in Brain Inflammation, Synaptic Proteins, and Adult Hippocampal Neurogenesis during Epileptogenesis in Mice Lacking Synapsin2.
Topics: Animals; Carrier Proteins; Cell Adhesion Molecules, Neuronal; Cerebral Cortex; Chemokines; Cytokines | 2015 |
Generalized seizures in a neural field model with bursting dynamics.
Topics: Action Potentials; Animals; Axons; Computer Simulation; Dendrites; Fourier Analysis; gamma-Aminobuty | 2015 |
Gamma-aminobutyric acid loaded halloysite nanotubes and in vitro-in vivo evaluation for brain delivery.
Topics: Aluminum Silicates; Animals; Brain; Cell Survival; Clay; Drug Carriers; Drug Liberation; Drug Stabil | 2015 |
Developmental and degenerative modulation of GABAergic transmission in the mouse hippocampus.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Disease Models, Animal; gamma-Aminobut | 2015 |
Involvement of the GABAergic system in the neuroprotective and sedative effects of acacetin 7-O-glucoside in rodents.
Topics: Animals; Anticonvulsants; CA1 Region, Hippocampal; Cerebral Cortex; Disease Models, Animal; Dose-Res | 2015 |
Pyridoxine deficiency in adult patients with status epilepticus.
Topics: Adult; Child; Electroencephalography; Female; gamma-Aminobutyric Acid; Humans; Pyridoxine; Seizures; | 2015 |
Toxoplasma gondii Infections Alter GABAergic Synapses and Signaling in the Central Nervous System.
Topics: Animals; Brain; Cell Movement; Disease Models, Animal; GABAergic Neurons; gamma-Aminobutyric Acid; G | 2015 |
Pharmacological treatment with mirtazapine rescues cortical atrophy and respiratory deficits in MeCP2 null mice.
Topics: Animals; Antidepressive Agents; Atrophy; Breath Tests; Cerebral Cortex; Desipramine; GABAergic Neuro | 2016 |
[MOLECULAR MECHANISMS OF ERK1/2 KINASES REGULATION IN THE GLUTAMATE- AND GABA-ERGIC NEURONS DURING SEIZURE EXPRESSION IN KRUSHINSKY-MOLODKINA RATS].
Topics: Acoustic Stimulation; Animals; Animals, Inbred Strains; Ataxia; Epilepsy, Reflex; Exocytosis; GABAer | 2015 |
Expression and cellular distribution of transient receptor potential vanilloid 4 in cortical tubers of the tuberous sclerosis complex.
Topics: Cerebral Cortex; Child; Child, Preschool; Cyclic AMP-Dependent Protein Kinases; Female; gamma-Aminob | 2016 |
Continuous bilateral infusion of vigabatrin into the subthalamic nucleus: Effects on seizure threshold and GABA metabolism in two rat models.
Topics: Animals; Basal Ganglia; Disease Models, Animal; Electric Stimulation; Female; gamma-Aminobutyric Aci | 2016 |
Design, Synthesis, and Biological Evaluation of 6-(2-Amino-substituted phenyl)-4-(substituted phenyl)-1,2,4-triazine-3,5(2H,4H)-dione Derivatives as Anticonvulsant Agents.
Topics: Animals; Anticonvulsants; Brain; Electroshock; gamma-Aminobutyric Acid; Mice; Molecular Docking Simu | 2016 |
Decreased Expression of Sox-1 in Cerebellum of Rat with Generalized Seizures Induced by Kindling Model.
Topics: Amygdala; Animals; Blotting, Western; Cerebellum; Chromatography, High Pressure Liquid; Disease Mode | 2016 |
Optogenetic dissection of ictal propagation in the hippocampal-entorhinal cortex structures.
Topics: Action Potentials; Animals; Dentate Gyrus; Entorhinal Cortex; gamma-Aminobutyric Acid; Hippocampus; | 2016 |
Influence of caffeine on the protective activity of gabapentin and topiramate in a mouse model of generalized tonic-clonic seizures.
Topics: Amines; Animals; Anticonvulsants; Caffeine; Cyclohexanecarboxylic Acids; Dose-Response Relationship, | 2016 |
Altered Function of the DnaJ Family Cochaperone DNJ-17 Modulates Locomotor Circuit Activity in a Caenorhabditis elegans Seizure Model.
Topics: Aldicarb; Amino Acid Sequence; Amino Acid Substitution; Animals; Behavior, Animal; Caenorhabditis el | 2016 |
Low-frequency electrical stimulation enhances the effectiveness of phenobarbital on GABAergic currents in hippocampal slices of kindled rats.
Topics: Animals; Anticonvulsants; CA1 Region, Hippocampal; Combined Modality Therapy; Disease Models, Animal | 2016 |
Ketogenic diet prevents neuronal firing increase within the substantia nigra during pentylenetetrazole-induced seizure in rats.
Topics: 3-Hydroxybutyric Acid; Action Potentials; Animals; Blood Glucose; Body Weight; Convulsants; Diet, Ke | 2016 |
Design, synthesis and evaluation of benzofuran-acetamide scaffold as potential anticonvulsant agent.
Topics: 4-Aminobutyrate Transaminase; Acetamides; Animals; Anticonvulsants; Benzofurans; Binding Sites; Cere | 2016 |
Involvement of ATP-sensitive potassium channels and the opioid system in the anticonvulsive effect of zolpidem in mice.
Topics: Analgesics, Opioid; Animals; Anticonvulsants; Cromakalim; Dose-Response Relationship, Drug; Drug The | 2016 |
Design, Synthesis and Evaluation of the Antidepressant and Anticonvulsant Activities of Triazole-Containing Benzo[d]oxazoles.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Benzoxazoles; Computer Simulation; Depressive Disor | 2017 |
NKCC1 up-regulation contributes to early post-traumatic seizures and increased post-traumatic seizure susceptibility.
Topics: Ammonia; Animals; Animals, Newborn; Bumetanide; Cell Count; Cerebral Cortex; Disease Models, Animal; | 2017 |
The role of IL-1β and glutamate in the effects of lipopolysaccharide on the hippocampal electrical kindling of seizures.
Topics: Analysis of Variance; Animals; Cytokines; Disease Models, Animal; Electric Stimulation; Electroencep | 2016 |
A case of refractory seizure with cognitive impairment due to anti-GABA encephalitis.
Topics: Cognitive Dysfunction; Encephalitis; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Seizures | 2016 |
Pro-Brain-Derived Neurotrophic Factor (proBDNF)-Mediated p75NTR Activation Promotes Depolarizing Actions of GABA and Increases Susceptibility to Epileptic Seizures.
Topics: Animals; Brain-Derived Neurotrophic Factor; Female; GABA Agents; gamma-Aminobutyric Acid; Male; Nerv | 2018 |
Altered glutamate metabolism contributes to antiepileptogenic effects in the progression from focal seizure to generalized seizure by low-frequency stimulation in the ventral hippocampus.
Topics: Animals; Cerebral Cortex; Dentate Gyrus; Disease Progression; Electric Stimulation; gamma-Aminobutyr | 2017 |
Protective effects of gabapentin against the seizure susceptibility and comorbid behavioral abnormalities in the early socially isolated mice.
Topics: Aggression; Amines; Animals; Anticonvulsants; Anxiety; Behavior, Animal; Comorbidity; Cyclohexanecar | 2017 |
Gabapentin-Induced Bullous Pemphigoid.
Topics: Aged, 80 and over; Amines; Biopsy, Needle; Cyclohexanecarboxylic Acids; Follow-Up Studies; Gabapenti | 2017 |
Parachlorophenylalanine-induced 5-HT depletion alters behavioral and brain neurotransmitters levels in 6-Hz psychomotor seizure model in mice.
Topics: Animals; Brain; Disease Models, Animal; Electroshock; gamma-Aminobutyric Acid; Glutamine; Male; Mice | 2017 |
Blockade of GABA synthesis only affects neural excitability under activated conditions in rat hippocampal slices.
Topics: 3-Mercaptopropionic Acid; Animals; Chromatography, High Pressure Liquid; Creatine; Electrophysiology | 2008 |
Intranigral transplants of a GABAergic cell line produce long-term alleviation of established motor seizures.
Topics: Animals; Behavior, Animal; Bisbenzimidazole; Cell Line, Transformed; Chromatography, High Pressure L | 2008 |
Betulin binds to gamma-aminobutyric acid receptors and exerts anticonvulsant action in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antineoplastic Agents; Betulinic | 2008 |
Pyramidal cell responses to gamma-aminobutyric acid differ in type I and type II cortical dysplasia.
Topics: Cells, Cultured; Child; Child, Preschool; Female; Fluorescent Antibody Technique; GABA Agonists; gam | 2008 |
Neuropsychiatric morbidity in adolescent and adult succinic semialdehyde dehydrogenase deficiency patients.
Topics: Adolescent; Adult; Amino Acid Metabolism, Inborn Errors; Ataxia; Behavioral Symptoms; Child; Child, | 2008 |
Ethyl 8-fluoro-6-(3-nitrophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate as novel, highly potent, and safe antianxiety agent.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Binding Sites; Brain; Cattle; Computer Simulation; Cr | 2008 |
Decreased number of interneurons and increased seizures in neuropilin 2 deficient mice: implications for autism and epilepsy.
Topics: Analysis of Variance; Animals; Biophysics; Cell Count; Electric Stimulation; gamma-Aminobutyric Acid | 2009 |
Tramadol-induced seizurogenic effect: a possible role of opioid-dependent gamma-aminobutyric acid inhibitory pathway.
Topics: Amines; Analgesics, Opioid; Animals; Cyclohexanecarboxylic Acids; GABA Agents; Gabapentin; gamma-Ami | 2008 |
Isobolographic and behavioral characterizations of interactions between vigabatrin and gabapentin in two experimental models of epilepsy.
Topics: Amines; Animals; Anticonvulsants; Behavior, Animal; Brain; Cyclohexanecarboxylic Acids; Disease Mode | 2008 |
Calpain activity contributes to the control of SNAP-25 levels in neurons.
Topics: Animals; Brain-Derived Neurotrophic Factor; Calcium; Calpain; Cells, Cultured; Coumarins; Dipeptides | 2008 |
[Paroxysmal kinesigenic dyskinesia: a channelopathy? Study of 19 cases].
Topics: Adolescent; Adult; Age of Onset; Amines; Anticonvulsants; Channelopathies; Child; Child, Preschool; | 2009 |
Pregabalin in patients with primary brain tumors and seizures: a preliminary observation.
Topics: Adult; Aged; Anticonvulsants; Brain Neoplasms; Epilepsies, Partial; Female; Follow-Up Studies; gamma | 2009 |
An insight on the neuropharmacological activity of Telescopium telescopium--a mollusc from the Sunderban mangrove.
Topics: Animals; Behavior, Animal; Body Temperature; Brain; Central Nervous System Depressants; Disease Mode | 2008 |
[Use of anticonvulsant pregabalin as an add-on therapy in patients with partial epilepsy with polymorphic seizures].
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsies, Partial; F | 2008 |
Effect of acoustic stimulation on GABAergic neurons in limbic structures of krushinskii-molodkina rats.
Topics: Acoustic Stimulation; Animals; Cell Count; gamma-Aminobutyric Acid; Interneurons; Limbic System; Neu | 2008 |
Efhc1 deficiency causes spontaneous myoclonus and increased seizure susceptibility.
Topics: Animals; Calcium-Binding Proteins; Cerebral Ventricles; Cilia; Convulsants; Dentate Gyrus; gamma-Ami | 2009 |
Pharmacodynamic and pharmacokinetic interaction profiles of levetiracetam in combination with gabapentin, tiagabine and vigabatrin in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis.
Topics: Amines; Animals; Anticonvulsants; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Drug I | 2009 |
Selective reorganization of GABAergic transmission in neonatal ventral hippocampal-lesioned rats.
Topics: Acoustic Stimulation; Action Potentials; Animals; Animals, Newborn; Apomorphine; Calbindin 2; Calbin | 2009 |
Effect of gabapentin on cognitive processes in rats not exposed and exposed to tobacco smoke during fetal life.
Topics: Amines; Animals; Anticonvulsants; Antidepressive Agents; Behavior, Animal; Cognition; Cyclohexanecar | 2008 |
Bumetanide, an NKCC1 antagonist, does not prevent formation of epileptogenic focus but blocks epileptic focus seizures in immature rat hippocampus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Animals, Newborn; Bicuculline; Bio | 2009 |
Mice lacking doublecortin and doublecortin-like kinase 2 display altered hippocampal neuronal maturation and spontaneous seizures.
Topics: Animals; Cell Differentiation; Cell Polarity; Dendrites; Doublecortin Domain Proteins; Doublecortin | 2009 |
Neocortical post-traumatic epileptogenesis is associated with loss of GABAergic neurons.
Topics: Animals; Brain Injuries; Cats; Cell Death; Craniotomy; Electrophysiology; Epilepsy; Female; gamma-Am | 2009 |
Evaluation of anticonvulsant activity of QUAN-0806 in various murine experimental seizure models.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Brain; Convulsants; Electroshock; Enzyme Act | 2009 |
Effects of isopulegol on pentylenetetrazol-induced convulsions in mice: possible involvement of GABAergic system and antioxidant activity.
Topics: Animals; Anticonvulsants; Antioxidants; Catalase; Cyclohexane Monoterpenes; Dose-Response Relationsh | 2009 |
The role of polar phytocomplexes on anticonvulsant effects of leaf extracts of Lippia alba (Mill.) N.E. Brown chemotypes.
Topics: Animals; Anticonvulsants; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Fl | 2009 |
Optical suppression of experimental seizures in rat brain slices.
Topics: 4-Aminopyridine; Animals; Convulsants; Disease Models, Animal; Epilepsies, Partial; GABA Agents; gam | 2010 |
Synchronization of GABAergic inputs to CA3 pyramidal cells precedes seizure-like event onset in juvenile rat hippocampal slices.
Topics: Aging; Animals; CA3 Region, Hippocampal; Chlorides; GABA Antagonists; gamma-Aminobutyric Acid; Gluta | 2009 |
Anticonvulsant activity of new GABA prodrugs.
Topics: Animals; Anticonvulsants; Behavior, Animal; Esterases; GABA-A Receptor Antagonists; gamma-Aminobutyr | 2009 |
Regionalized loss of parvalbumin interneurons in the cerebral cortex of mice with deficits in GFRalpha1 signaling.
Topics: Action Potentials; Age Factors; Animals; Animals, Newborn; Brain Mapping; Caspase 3; Cell Death; Cer | 2009 |
Lack of kainic acid-induced gamma oscillations predicts subsequent CA1 excitotoxic cell death.
Topics: Action Potentials; Analysis of Variance; Animals; Cell Count; Cell Death; Electrophysiology; Excitat | 2009 |
Differences in cortical versus subcortical GABAergic signaling: a candidate mechanism of electroclinical uncoupling of neonatal seizures.
Topics: Amygdala; Animals; Animals, Newborn; Anticonvulsants; Bumetanide; Chlorides; Female; gamma-Aminobuty | 2009 |
Quadratic inference functions in marginal models for longitudinal data.
Topics: Anticonvulsants; Computer Simulation; Data Interpretation, Statistical; gamma-Aminobutyric Acid; Hum | 2009 |
Pharmacogenetic analysis reveals a post-developmental role for Rac GTPases in Caenorhabditis elegans GABAergic neurotransmission.
Topics: Aldicarb; Animals; Biological Transport; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Ce | 2009 |
Long-term suppression of GABAergic activity by neonatal seizures in rat somatosensory cortex.
Topics: Animals; Animals, Newborn; Flurothyl; gamma-Aminobutyric Acid; Inhibitory Postsynaptic Potentials; M | 2009 |
Synthesis of N4-(2,4-dimethylphenyl) semicarbazones as 4-aminobutyrate aminotransferase inhibitors.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Behavior, Animal; Brain; Disease Models, Ani | 2006 |
Intrastrain differences in seizure susceptibility, pharmacological response and basal neurochemistry of Wistar rats.
Topics: Analysis of Variance; Anesthetics, Dissociative; Animals; Biogenic Monoamines; Body Weight; Brain; B | 2009 |
Hepatocyte growth factor (HGF) modulates GABAergic inhibition and seizure susceptibility.
Topics: Action Potentials; Analysis of Variance; Animals; Animals, Genetically Modified; Animals, Newborn; A | 2010 |
Antiepileptic drugs combined with high-frequency electrical stimulation in the ventral hippocampus modify pilocarpine-induced status epilepticus in rats.
Topics: Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Disease Models, Animal; Electric Stim | 2010 |
Seizure sensitivity is ameliorated by targeted expression of K+-Cl- cotransporter function in the mushroom body of the Drosophila brain.
Topics: Animals; Behavior, Animal; Brain; Disease Susceptibility; Drosophila melanogaster; Electrophysiologi | 2010 |
Reduction of seizures by transplantation of embryonic GABAergic interneurons into Kv1.1 mutant mice.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Interneurons; Kv1.1 Potassium Channel; Mic | 2009 |
Comparison of the antiepileptic properties of transmeningeally delivered muscimol, lidocaine, midazolam, pentobarbital and GABA, in rats.
Topics: Acetylcholine; Animals; Anticonvulsants; Electrodes, Implanted; Electroencephalography; gamma-Aminob | 2010 |
Monosodium glutamate neonatal treatment as a seizure and excitotoxic model.
Topics: Amino Acids; Animals; Animals, Newborn; Biosensing Techniques; Cerebral Ventricles; Disease Models, | 2010 |
Altered function of the SCN1A voltage-gated sodium channel leads to gamma-aminobutyric acid-ergic (GABAergic) interneuron abnormalities.
Topics: Animals; Female; gamma-Aminobutyric Acid; Gene Expression Regulation; Homozygote; Interneurons; Male | 2010 |
Anticonvulsant activity of Benkara malabarica (Linn.) root extract: In vitro and in vivo investigation.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Diazepam; Drug Interactions; Enzyme Assays; | 2010 |
Interactions of 1-methyl-1,2,3,4-tetrahydroisoquinoline with lamotrigine, oxcarbazepine, pregabalin, and topiramate in the mouse maximal electroshock-induced seizure model: a type I isobolographic analysis.
Topics: Animals; Anticonvulsants; Avoidance Learning; Carbamazepine; Disease Models, Animal; Dopamine Antago | 2010 |
Aneseizure: is the neonatal brain asleep?
Topics: Anesthesia, General; Anesthetics; Brain; GABA Agents; gamma-Aminobutyric Acid; Humans; Infant, Newbo | 2010 |
Hippocampal sst(1) receptors are autoreceptors and do not affect seizures in rats.
Topics: Animals; Autoreceptors; Chromatography, Liquid; gamma-Aminobutyric Acid; Hippocampus; Male; Microdia | 2010 |
Transplant of GABAergic precursors restores hippocampal inhibitory function in a mouse model of seizure susceptibility.
Topics: Animals; Disease Models, Animal; Fluorescent Antibody Technique; gamma-Aminobutyric Acid; Hippocampu | 2010 |
A mutant thyroid hormone receptor alpha1 alters hippocampal circuitry and reduces seizure susceptibility in mice.
Topics: Animals; Brain; Calbindin 2; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; Hypo | 2010 |
Comparative anticonvulsant activities of the essential oils (EOs) from Cymbopogon winterianus Jowitt and Cymbopogon citratus (DC) Stapf. in mice.
Topics: Animals; Anticonvulsants; Brazil; Cymbopogon; Disease Models, Animal; Dose-Response Relationship, Dr | 2010 |
Magnesium supplementation enhances the anticonvulsant potential of valproate in pentylenetetrazol-treated rats.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Drug Synergism; gamma-Aminobutyric Acid; Gl | 2010 |
Effect of gene dosage on single-cell hippocampal electrophysiology in a murine model of SSADH deficiency (gamma-hydroxybutyric aciduria).
Topics: Animals; Animals, Newborn; Biophysics; Disease Models, Animal; Dose-Response Relationship, Drug; Ele | 2010 |
Interaction of pregabalin with carbamazepine in the mouse maximal electroshock-induced seizure model: a type I isobolographic analysis for non-parallel dose-response relationship curves.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Drug Interactions; Electroshock; ga | 2010 |
Passiflora incarnata L. (Passionflower) extracts elicit GABA currents in hippocampal neurons in vitro, and show anxiogenic and anticonvulsant effects in vivo, varying with extraction method.
Topics: Animals; Anticonvulsants; Anxiety; Dose-Response Relationship, Drug; Flavonoids; GABA Agonists; gamm | 2010 |
Diphenyl diselenide-induced seizures in rat pups: possible interaction with GABAergic system.
Topics: Acetanilides; Animals; Animals, Newborn; Benzene Derivatives; Diazepam; Disease Models, Animal; Dose | 2010 |
Distinct FGFs promote differentiation of excitatory and inhibitory synapses.
Topics: Animals; Cell Differentiation; Cells, Cultured; Dendrites; Disease Susceptibility; Epilepsy; Excitat | 2010 |
The testosterone-derived neurosteroid androstanediol is a positive allosteric modulator of GABAA receptors.
Topics: Androgen Antagonists; Androstane-3,17-diol; Animals; CA1 Region, Hippocampal; Data Interpretation, S | 2010 |
Effect of cross-fostering on seizures in adult male offspring of methamphetamine-treated rat mothers.
Topics: Amphetamine-Related Disorders; Animals; Female; gamma-Aminobutyric Acid; Male; Maternal Behavior; Me | 2010 |
Interneurons, GABAA currents, and subunit composition of the GABAA receptor in type I and type II cortical dysplasia.
Topics: Child; gamma-Aminobutyric Acid; Humans; Interneurons; Malformations of Cortical Development; Neocort | 2010 |
Blocking early GABA depolarization with bumetanide results in permanent alterations in cortical circuits and sensorimotor gating deficits.
Topics: Animals; Bumetanide; Cerebral Cortex; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; I | 2011 |
Lipoic acid alters amino acid neurotransmitters content in rat hippocampus after pilocarpine-induced seizures.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dialysis; Excitatory Amino Acids; gamma-Aminobutyric Acid; | 2011 |
Additive interactions of pregabalin with lamotrigine, oxcarbazepine and topiramate in the mouse maximal electroshock-induced seizure model: a type I isobolographic analysis for non-parallel dose-response relationship curves.
Topics: Animals; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; | 2010 |
Anticonvulsive effect of vitamin C on pentylenetetrazol-induced seizures in immature rats.
Topics: Animals; Anticonvulsants; Ascorbic Acid; Aspartic Acid; Brain Chemistry; Chromatography, High Pressu | 2010 |
Pharmacological characterization of GABAA receptors in taurine-fed mice.
Topics: Animals; Behavior, Animal; GABA Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Male; | 2010 |
GABAergic compensation in connexin36 knock-out mice evident during low-magnesium seizure-like event activity.
Topics: Animals; Connexins; Electroencephalography; Electrophysiological Phenomena; Etomidate; Female; GABA | 2010 |
Spontaneous seizures and altered gene expression in GABA signaling pathways in a mind bomb mutant zebrafish.
Topics: Animals; Brain; Electrophysiology; Female; gamma-Aminobutyric Acid; In Situ Hybridization; Male; Mot | 2010 |
The GluK1 (GluR5) Kainate/{alpha}-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist LY293558 reduces soman-induced seizures and neuropathology.
Topics: Animals; Chemical Warfare Agents; Electroencephalography; gamma-Aminobutyric Acid; Interneurons; Iso | 2011 |
Perinatal hypoxia induces a long-lasting increase in unstimulated gaba release in rat brain cortex and hippocampus. The protective effect of pyruvate.
Topics: Animals; Animals, Newborn; Cerebral Cortex; Dose-Response Relationship, Drug; Extracellular Space; g | 2011 |
Pancreatitis-associated protein-I and pancreatitis-associated protein-III expression in a rat model of kainic acid-induced seizure.
Topics: Aminopeptidases; Animals; Antigens, Neoplasm; Biomarkers, Tumor; Disease Models, Animal; Epilepsy, T | 2011 |
Inference on the rate ratio of recurrent events for the matched pairs design.
Topics: Anticonvulsants; Data Interpretation, Statistical; Epilepsy; gamma-Aminobutyric Acid; Humans; Incide | 2010 |
Amisulpride-induced seizurogenic effect: a potential role of opioid receptor-linked transduction systems.
Topics: Amines; Amisulpride; Analysis of Variance; Animals; Anti-Asthmatic Agents; Cromolyn Sodium; Cyclohex | 2011 |
Increased GABAergic inhibition in the midline thalamus affects signaling and seizure spread in the hippocampus-prefrontal cortex pathway.
Topics: Animals; Electric Stimulation; Electroencephalography; Epilepsy, Temporal Lobe; Evoked Potentials; G | 2011 |
Effect of combined treatment of thioperamide with some antiepileptic drugs on methionine-sulfoximine induced convulsions in mice.
Topics: Amines; Animals; Anticonvulsants; Brain; Cyclohexanecarboxylic Acids; Drug Combinations; Gabapentin; | 2010 |
Adjunctive pregabalin for uncontrolled partial-onset seizures: findings from a prospective audit.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Body Weight; Dose-Response Relationship, Drug; Drug Admini | 2011 |
7-Nitroindazole, but not NG-nitro-L-arginine, enhances the anticonvulsant activity of pregabalin in the mouse maximal electroshock-induced seizure model.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; | 2011 |
Effects of high frequency electrical stimulation and R-verapamil on seizure susceptibility and glutamate and GABA release in a model of phenytoin-resistant seizures.
Topics: Animals; Disease Models, Animal; Disease Susceptibility; Drug Resistance; Electric Stimulation; Extr | 2011 |
Performance characteristics of the ARK diagnostics gabapentin immunoassay.
Topics: Amines; Anticonvulsants; Blood Chemical Analysis; Chromatography, High Pressure Liquid; Cyclohexanec | 2011 |
Role of CB1 cannabinoid receptors on GABAergic neurons in brain aging.
Topics: Aging; Animals; Brain; Cell Count; Female; gamma-Aminobutyric Acid; Gene Expression; Hippocampus; In | 2011 |
Plasticity-modulated seizure dynamics for seizure termination in realistic neuronal models.
Topics: Algorithms; Animals; Cyclic Nucleotide-Gated Cation Channels; Epilepsy, Absence; gamma-Aminobutyric | 2011 |
Neurobiological activity of Parawixin 10, a novel anticonvulsant compound isolated from Parawixia bistriata spider venom (Araneidae: Araneae).
Topics: Analysis of Variance; Animals; Anticonvulsants; Ataxia; Cerebral Cortex; Chromatography, High Pressu | 2011 |
Propofol protects against impairment of learning-memory and imbalance of hippocampal Glu/GABA induced by electroconvulsive shock in depressed rats.
Topics: Animals; Cognition; Depression; Down-Regulation; Electroconvulsive Therapy; Electroshock; gamma-Amin | 2011 |
Behavioral and EEG effects of GABAergic manipulation of the nigrotectal pathway in the Wistar audiogenic rat strain.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Bicuculline; Corpus Striatum; Electroencephalog | 2011 |
Downregulation of hippocampal GABA after hypoxia-induced seizures in neonatal rats.
Topics: Animals; Animals, Newborn; Disease Susceptibility; Down-Regulation; Epilepsy; gamma-Aminobutyric Aci | 2011 |
Interactions of pregabalin with gabapentin, levetiracetam, tiagabine and vigabatrin in the mouse maximal electroshock-induced seizure model: a type II isobolographic analysis.
Topics: Amines; Animals; Anticonvulsants; Avoidance Learning; Confidence Intervals; Cyclohexanecarboxylic Ac | 2012 |
Transition to seizure: from "macro"- to "micro"-mysteries.
Topics: Brain; Electroencephalography; gamma-Aminobutyric Acid; Humans; Models, Neurological; Nerve Net; Neu | 2011 |
Involvement of GABAergic and glutamatergic systems in the anticonvulsant activity of 3-alkynyl selenophene in 21 day-old rats.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Excitatory Amino Acid Agonists; GABAergic Neurons; gamma- | 2012 |
Influence of carvedilol on anticonvulsant effect of gabapentin.
Topics: Amines; Analysis of Variance; Animals; Anticonvulsants; Brain; Carbazoles; Carvedilol; Convulsants; | 2011 |
Erysothrine, an alkaloid extracted from flowers of Erythrina mulungu Mart. ex Benth: evaluating its anticonvulsant and anxiolytic potential.
Topics: Alkaloids; Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Convulsants; Diazepam; Disease Mo | 2012 |
Transition to seizure: ictal discharge is preceded by exhausted presynaptic GABA release in the hippocampal CA3 region.
Topics: Animals; CA3 Region, Hippocampal; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Inhib | 2012 |
m-Trifluoromethyl diphenyl diselenide attenuates glutaric acid-induced seizures and oxidative stress in rat pups: involvement of the γ-aminobutyric acidergic system.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Anticonvulsants; Brain Diseases, Metabolic; Disease M | 2012 |
Neuroprotective effects of vitexin, a flavonoid, on pentylenetetrazole-induced seizure in rats.
Topics: Animals; Anticonvulsants; Apigenin; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Male; Neur | 2012 |
Activity-dependent alternative splicing increases persistent sodium current and promotes seizure.
Topics: Alternative Splicing; Animals; Drosophila Proteins; Exons; gamma-Aminobutyric Acid; Membrane Potenti | 2012 |
Inactivation of the constitutively active ghrelin receptor attenuates limbic seizure activity in rodents.
Topics: Analysis of Variance; Animals; Anticonvulsants; Calcium; Disease Models, Animal; Disease Susceptibil | 2012 |
Combination of valproate and paroxetine in mice exposed to picrotoxin.
Topics: Animals; Anticonvulsants; Brain Chemistry; Drug Combinations; gamma-Aminobutyric Acid; Mice; Nucleus | 2012 |
Sildenafil influences the anticonvulsant activity of vigabatrin and gabapentin in the timed pentylenetetrazole infusion test in mice.
Topics: Amines; Animals; Anticonvulsants; Avoidance Learning; Cyclohexanecarboxylic Acids; Disease Models, A | 2012 |
Zebrafish larvae exposed to ginkgotoxin exhibit seizure-like behavior that is relieved by pyridoxal-5'-phosphate, GABA and anti-epileptic drugs.
Topics: Animals; Anticonvulsants; Behavior, Animal; Carbon; Folic Acid; gamma-Aminobutyric Acid; Larva; Mode | 2012 |
Chronic h1-antihistamine treatment increases seizure susceptibility after withdrawal by impairing glutamine synthetase.
Topics: Animals; Astrocytes; Blotting, Western; Chromatography, High Pressure Liquid; Convulsants; Electrosh | 2012 |
The dynamics of changes in hippocampal GABAergic system in rats exposed to early-life hypoxia-induced seizures.
Topics: Animals; Cell Membrane; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Hippocampu | 2012 |
Mice expressing the ADNFLE valine 287 leucine mutation of the Β2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function.
Topics: Acetylcholine; Animals; Body Temperature; Central Nervous System Sensitization; Cerebral Cortex; Dop | 2013 |
Tranexamic acid concentrations associated with human seizures inhibit glycine receptors.
Topics: Adult; Aged; Aged, 80 and over; Aminocaproic Acid; Animals; Anticonvulsants; Aprotinin; Binding, Com | 2012 |
Anticonvulsant effects by bilateral and unilateral transplantation of GABA-producing cells into the subthalamic nucleus in an acute seizure model.
Topics: Acute Disease; Animals; Brain Tissue Transplantation; Corpus Striatum; Disease Models, Animal; Femal | 2014 |
Use of pregabalin for nonconvulsive seizures and nonconvulsive status epilepticus.
Topics: Anticonvulsants; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Pregabalin; Retrospecti | 2013 |
A bias correction for covariance estimators to improve inference with generalized estimating equations that use an unstructured correlation matrix.
Topics: Anticonvulsants; Bias; Computer Simulation; Epilepsy; gamma-Aminobutyric Acid; Humans; Longitudinal | 2013 |
Novel limonene and citral based 2,5-disubstituted-1,3,4-oxadiazoles: a natural product coupled approach to semicarbazones for antiepileptic activity.
Topics: Acyclic Monoterpenes; Animals; Anticonvulsants; Binding Sites; Cyclohexenes; Disease Models, Animal; | 2013 |
Antiepileptic drugs prevent changes in adenosine deamination during acute seizure episodes in adult zebrafish.
Topics: Adenine Nucleotides; Adenosine; Adenosine Deaminase; Amines; Animals; Anticonvulsants; Brain; Cycloh | 2013 |
Piperine decreases pilocarpine-induced convulsions by GABAergic mechanisms.
Topics: Alkaloids; Amino Acids; Animals; Anticonvulsants; Antioxidants; Atropine; Benzodioxoles; Biogenic Mo | 2013 |
L-Theanine intake increases threshold for limbic seizures but decreases threshold for generalized seizures.
Topics: Animals; Disease Models, Animal; GABA Agents; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hi | 2013 |
Design and synthesis of some new quinazolin-4-(3H)-ones as anticonvulsant and antidepressant agents.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Brain; Disease Models, Animal; Drug Design; gamma-A | 2013 |
Changes in extracellular levels of amygdala amino acids in genetically fast and slow kindling rat strains.
Topics: Amino Acids; Amygdala; Animals; Differential Threshold; Electrophysiology; Extracellular Space; gamm | 2002 |
Evidence for an involvement of nitric oxide and gamma aminobutyric acid in the anticonvulsant action of L-arginine on picrotoxin-induced convulsions in rats.
Topics: Animals; Anticonvulsants; Arginine; Brain; Dose-Response Relationship, Drug; Enzyme Inhibitors; gamm | 2002 |
Effect of gabapentin on the anticonvulsant activity of antiepileptic drugs against electroconvulsions in mice: an isobolographic analysis.
Topics: Acetates; Amines; Animals; Anticonvulsants; Behavior, Animal; Cyclohexanecarboxylic Acids; Disease M | 2002 |
Anxiolytic and anticonvulsive activity of Sesbania grandiflora leaves in experimental animals.
Topics: Amphetamine; Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Brain Chemistry; Elect | 2002 |
Sedative, anticonvulsant and behaviour modifying effects of Centranthus longiflorus ssp. longiflorus: a study of comparison to diazepam.
Topics: Adenosine; Animals; Anticonvulsants; Behavior, Animal; Caffeine; Central Nervous System Stimulants; | 2002 |
Long-term regulation of voltage-gated Ca(2+) channels by gabapentin.
Topics: Acetates; Amines; Animals; Anticonvulsants; Brain; Calcium Channels, P-Type; Calcium Channels, Q-Typ | 2002 |
The altered expression of GABA shunt enzymes in the gerbil hippocampus before and after seizure generation.
Topics: Aldehyde Oxidoreductases; Animals; gamma-Aminobutyric Acid; Gerbillinae; Hippocampus; Hydroxybutyrat | 2003 |
The expression of GABA in mossy fiber synaptosomes coincides with the seizure-induced expression of GABAergic transmission in the mossy fiber synapse.
Topics: Animals; gamma-Aminobutyric Acid; Male; Mossy Fibers, Hippocampal; Rats; Rats, Wistar; Seizures; Syn | 2002 |
N-, alpha-, and beta-Substituted 3-Aminopropionic acids: design, syntheses and antiseizure activities.
Topics: Animals; Anticonvulsants; Binding Sites; Electroshock; gamma-Aminobutyric Acid; Glycine; Male; Model | 2003 |
The epileptogenic effect of seizures induced by hypoxia: the role of NMDA and AMPA/KA antagonists.
Topics: Animals; Avoidance Learning; Bicuculline; Brain Chemistry; Dizocilpine Maleate; Epilepsy; Excitatory | 2003 |
Inhibition of acute hyperammonemia-induced convulsions by systemically administered gamma aminobutyric acid in rats.
Topics: Ammonia; Animals; Brain; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Hyperammonemia; | 2003 |
Coadministration of gabapentin or MK-801 with lamotrigine slows tolerance to its anticonvulsant effects on kindled seizures.
Topics: Acetates; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Dizocilpine Maleate; Drug T | 2003 |
Gastrodin decreases immunoreactivities of gamma-aminobutyric acid shunt enzymes in the hippocampus of seizure-sensitive gerbils.
Topics: Animals; Benzyl Alcohols; gamma-Aminobutyric Acid; Gerbillinae; Glucosides; Glutamate Decarboxylase; | 2003 |
Reduced inhibition within primary motor cortex in patients with poststroke focal motor seizures.
Topics: Electric Stimulation; Electromagnetic Fields; gamma-Aminobutyric Acid; Humans; Interneurons; Motor C | 2003 |
Activity-dependent induction of multitransmitter signaling onto pyramidal cells and interneurons of hippocampal area CA3.
Topics: Acetylcholine; Animals; Choline O-Acetyltransferase; Dentate Gyrus; Electrophysiology; Excitatory Am | 2003 |
Synergistic interaction between felbamate and lamotrigine against seizures induced by 4-aminopyridine and pentylenetetrazole in mice.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Brain; Dose-Response Relationship, Drug; Drug Synergism; | 2003 |
In vivo measurement of brain metabolites using two-dimensional double-quantum MR spectroscopy--exploration of GABA levels in a ketogenic diet.
Topics: Adult; Brain; Brain Mapping; Child; Child, Preschool; Feasibility Studies; Female; gamma-Aminobutyri | 2003 |
Pharmacological evaluation of garenoxacin, a novel des-F(6)-quinolone antimicrobial agent: effects on the central nervous system.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Central Nervous System; Drug Interactions; Fluoroq | 2003 |
Clinical spectrum of succinic semialdehyde dehydrogenase deficiency.
Topics: Adolescent; Adult; Aldehyde Oxidoreductases; Autistic Disorder; Child; Child, Preschool; Cohort Stud | 2003 |
Pentylenetetrazole decreases metabolic glutamate turnover in rat brain.
Topics: Animals; Brain; Brain Chemistry; Carbon Isotopes; Cerebellum; Cerebral Cortex; Chromatography, High | 2003 |
Excitatory GABA input directly drives seizure-like rhythmic synchronization in mature hippocampal CA1 pyramidal cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetazolamide; Animals; Animals, Newborn; Anti-Ulcer Agents; A | 2003 |
Susceptibility to kainate-induced seizures under dietary zinc deficiency.
Topics: Animals; Brain; Brain Chemistry; Deficiency Diseases; Disease Susceptibility; Dose-Response Relation | 2003 |
Is the interaction between felbamate and valproate against seizures induced by 4-aminopyridine and pentylenetetrazole in mice beneficial?
Topics: 4-Aminopyridine; Analysis of Variance; Animals; Brain; Chromatography, Liquid; Disease Models, Anima | 2003 |
GABAergic systems modulate nicotinic receptor-mediated seizures in mice.
Topics: Animals; Convulsants; gamma-Aminobutyric Acid; Mice; Nicotinic Agonists; Nicotinic Antagonists; Rece | 2003 |
Sex differences in GABA(A)ergic system in rat substantia nigra pars reticulata.
Topics: Age Factors; Animals; Cell Count; Female; gamma-Aminobutyric Acid; Immunohistochemistry; In Situ Hyb | 2003 |
Glutamic acid and gamma-aminobutyric acid in seizures.
Topics: Amino Acids; Cerebral Cortex; Epilepsy; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Seizures | 1957 |
On the efficacy of asparagine, glutamine, gamma-aminobutyric acid and 1-pyrroiidinone in preventing chemically induced seizures in mice.
Topics: Amino Acids; Animals; Asparagine; Central Nervous System Stimulants; gamma-Aminobutyric Acid; Glutam | 1957 |
The inhibitory action of beta-hydroxy-gamma-aminobutyric acid upon the seizure following stimulation of the motor cortex of the dog.
Topics: Amino Acids; Aminobutyrates; Animals; Cerebral Cortex; Dogs; gamma-Aminobutyric Acid; Motor Cortex; | 1959 |
[Seizures caused by the crude GABOB injected into cerebrospinal fluid of normal and epileptic dogs].
Topics: Amino Acids; Animals; Dogs; Epilepsy; gamma-Aminobutyric Acid; Seizures | 1961 |
gamma-Aminobutyric acid and seizure susceptibility in area of normal cat brain cortex.
Topics: Amino Acids; Animals; Brain; Cats; Cerebral Cortex; Disease Susceptibility; gamma-Aminobutyric Acid; | 1960 |
Demonstration of thiosemicarbazide-induced convulsions in rats with elevated brain levels of gamma-aminobutyric acid.
Topics: Amino Acids; Animals; Brain; gamma-Aminobutyric Acid; Hydrazines; Neurochemistry; Rats; Seizures; Se | 1960 |
[The gamma-aminobutyric acid content in brain tissue in convulsions].
Topics: Amino Acids; Brain; gamma-Aminobutyric Acid; Seizures | 1962 |
Trial of amino-oxyacetic acid, an anticonvulsant.
Topics: Amino Acids; Anticonvulsants; Brain; Child; Epilepsy; Epilepsy, Tonic-Clonic; gamma-Aminobutyric Aci | 1963 |
Effect of intraventricular injection of N-methylated GABA-derivatives on the central nervous system of conscious mice.
Topics: Amino Acids; Animals; Central Nervous System; gamma-Aminobutyric Acid; Injections, Intraventricular; | 1963 |
THE SYNTHESIS AND GAMMA-AMINOBUTYRIC ACID TRANSAMINASE INHIBITION OF AMINOOEXY ACIDS AND RELATED COMPOUNDS.
Topics: Amino Acids; Aminobutyrates; Animals; Chemical Phenomena; Chemistry; Enzyme Inhibitors; gamma-Aminob | 1962 |
GAMMA-AMINOBUTYRIC ACID LEVELS IN THE BRAIN OF RATS EXPOSED TO OXYGEN AT HIGH PRESSURES.
Topics: Aminobutyrates; Aspartic Acid; Atmospheric Pressure; Brain; gamma-Aminobutyric Acid; Glutamates; Met | 1963 |
[EFFECT OF TOTAL ROENTGEN IRRADIATION ON THE CONTENT OF GAMMA-AMINOBUTYRIC ACID IN BRAIN TISSUE].
Topics: Aminobutyrates; Amobarbital; Brain; Cystamine; gamma-Aminobutyric Acid; Glutamates; Metabolism; Radi | 1963 |
CENTRALLY ACTIVE 2-(SUBSTITUTED PHENYL)-GAMMA-AMINOBUTYRIC ACIDS.
Topics: Aminobutyrates; Central Nervous System; Chemistry, Pharmaceutical; gamma-Aminobutyric Acid; Mice; Ph | 1963 |
[EFFECT OF GAMMA-AMINOBUTYRIC ACID ON THE CONVULSION POTENTIAL].
Topics: Aminobutyrates; Brain; Cats; Cerebral Cortex; Electromyography; Electrophysiological Phenomena; Elec | 1964 |
[GABOB IN PEDIATRICS. CLINICAL AND ELECTROENCEPHALOGRAPHIC STUDY OF 28 CASES].
Topics: Adolescent; Aminobutyrates; Barbiturates; Brain Injuries; Cerebral Palsy; Child; Electroencephalogra | 1964 |
THE EFFECTS OF HYDRAZINES ON RAT BRAIN 5-HYDROXYTRYPTAMINE, NOREPINEPHRINE, AND GAMMA-AMINOBUTYRIC ACID.
Topics: Aminobutyrates; Cerebellum; Cerebral Cortex; Chromatography; Diencephalon; Fluorescence; gamma-Amino | 1964 |
THE ACTION OF SODIUM 4-HYDROXYBUTYRATE ON SPINAL REFLEXES.
Topics: Aminobutyrates; Anesthesia; Anesthesia, Local; Anesthesiology; Animals; Blood Pressure Determination | 1964 |
TREATMENT OF EPILEPSY BY INTRASPINAL INJECTION OF GAMMA-AMINO-BETA-HYDROXYBUTYRIC ACID (GABOB).
Topics: Adolescent; Anticonvulsants; Drug Therapy; Electroencephalography; Epilepsy; Epilepsy, Tonic-Clonic; | 1964 |
THE DISTRIBUTION OF GAMMA-AMINOBUTYRIC ACID IN THE MONKEY BRAIN DURING PICROTOXIN-INDUCED SEIZURES.
Topics: Aminobutyrates; Animals; Brain; Brain Chemistry; Chromatography; gamma-Aminobutyric Acid; Glutamates | 1964 |
ANTICONVULSIVE ACTION OF SUBSTANCES DESIGNED AS INHIBITORS OF GAMMA-AMINOBUTYRIC ACID-ALPHA-KETOGLUTARIC ACID TRANSAMINASE.
Topics: Aminobutyrates; Animals; Anticonvulsants; Blood-Brain Barrier; Brain; Electricity; Electroshock; Enz | 1964 |
A NEUROPHARMACOLOGICAL STUDY OF GAMMA-AMINOBUTYRIC ACID (GABA).
Topics: Aminobutyrates; Anesthesia; Anesthesia, Intravenous; Behavior, Animal; Brain Chemistry; Cats; Chlorp | 1964 |
EFFECT OF GAMMA-AMINOBUTYRIC ACID UPON STRYCHNINE CONVULSIONS.
Topics: Aminobutyrates; gamma-Aminobutyric Acid; Pharmacology; Rats; Research; Seizures; Strychnine; Toxicol | 1965 |
THE INFLUENCE OF GAMMA-AMINOBUTYRIC ACID (GABA) ON SEIZURE POTENTIALS.
Topics: Aminobutyrates; Brain; Cats; Cerebral Cortex; Electrophysiological Phenomena; Electrophysiology; gam | 1965 |
PULMONARY AND CENTRAL NERVOUS SYSTEM DAMAGE IN RATS EXPOSED TO HYPERBARIC OXYGEN AND PROTECTION THEREFROM BY GAMMA-AMINOBUTYRIC ACID.
Topics: Aminobutyrates; Antidotes; Central Nervous System; gamma-Aminobutyric Acid; Hyperbaric Oxygenation; | 1965 |
EFFECT OF GAMMA-AMINOBUTYRIC ACID UPON BRUCINE CONVULSIONS.
Topics: Aminobutyrates; gamma-Aminobutyric Acid; Pharmacology; Rats; Research; Seizures; Strychnine; Synapse | 1965 |
Effects of pyridoxine, gamma-aminobutyric acid and gamma-amino-beta-hydroxybutyric acid on the convulsions of dogs caused by toxopyrimidine or isonicotinic acid hydrazide.
Topics: Amino Acids; Animals; Antifibrinolytic Agents; Dogs; gamma-Aminobutyric Acid; Isoniazid; Pyridoxine; | 1962 |
On the relationship of brain gamma-aminobutyric acid to convulsions.
Topics: Amino Acids; Antifibrinolytic Agents; Brain; Brain Chemistry; gamma-Aminobutyric Acid; Seizures | 1962 |
Glutamatergic propagation of GABAergic seizure-like afterdischarge in the hippocampus in vitro.
Topics: Animals; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Membrane Potentials; Rats; Rats, Wista | 2003 |
Overexpression of spermidine/spermine N1-acetyltransferase elevates the threshold to pentylenetetrazol-induced seizure activity in transgenic mice.
Topics: Acetyltransferases; Animals; Biogenic Polyamines; Brain; Cell Count; Crosses, Genetic; Dose-Response | 2003 |
Design, synthesis and anticonvulsive activities of potential prodrugs linked by two-carbon chain.
Topics: Animals; Anticonvulsants; Carbon; Convulsants; Dimerization; Drug Design; Electroshock; gamma-Aminob | 2003 |
Sleep oscillations developing into seizures in corticothalamic systems.
Topics: Animals; Cats; Cerebral Cortex; Diagnosis, Differential; Electroencephalography; Epilepsy, Absence; | 2003 |
Transplants of cells engineered to produce GABA suppress spontaneous seizures.
Topics: Animals; Cell Culture Techniques; Cell Transplantation; Cerebral Cortex; Disease Models, Animal; gam | 2004 |
Effect of valproic acid on levels of GABA and glutamic acid in pentylenetetrazole-damaged rat brain.
Topics: Animals; Anticonvulsants; Body Weight; Brain Chemistry; Convulsants; gamma-Aminobutyric Acid; Glutam | 2003 |
Potential pleiotropic effects of Mpdz on vulnerability to seizures.
Topics: Amino Acid Motifs; Animals; Carrier Proteins; Chromosome Mapping; Convulsants; Ethanol; Female; gamm | 2004 |
Treatment with the antiepileptic drugs phenytoin and gabapentin ameliorates seizure and paralysis of Drosophila bang-sensitive mutants.
Topics: Acetates; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Dose-Response Relationship, | 2004 |
Developmental changes in GABAergic actions and seizure susceptibility in the rat hippocampus.
Topics: Aging; Animals; Animals, Newborn; Bicuculline; Disease Susceptibility; Excitatory Postsynaptic Poten | 2004 |
Isobolographic profile of interactions between tiagabine and gabapentin: a preclinical study.
Topics: Amines; Animals; Anticonvulsants; Convulsants; Cyclohexanecarboxylic Acids; Dose-Response Relationsh | 2004 |
In vivo modulation of extracellular hippocampal glutamate and GABA levels and limbic seizures by group I and II metabotropic glutamate receptor ligands.
Topics: Amino Acids; Animals; Anticonvulsants; Benzoates; Bridged Bicyclo Compounds, Heterocyclic; Cycloprop | 2004 |
Proton MR spectroscopy in succinic semialdehyde dehydrogenase deficiency.
Topics: Adult; Aldehyde Oxidoreductases; Amino Acid Metabolism, Inborn Errors; Brain; gamma-Aminobutyric Aci | 2004 |
Altered GABAergic neurotransmission in mice lacking dopamine D2 receptors.
Topics: Animals; Basal Ganglia; Brain Chemistry; Dopamine; Electroencephalography; Enkephalins; GABA Agonist | 2004 |
Altered Na+-K+ ATPase immunoreactivity within GABAergic neurons in the gerbil hippocampal complex induced by spontaneous seizure and vigabatrin treatment.
Topics: Animals; gamma-Aminobutyric Acid; Gerbillinae; Hippocampus; Neurons; Seizures; Sodium-Potassium-Exch | 2004 |
Synaptic interactions between pyramidal cells and interneurone subtypes during seizure-like activity in the rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Electric Stimulation; El | 2004 |
Antiepileptic drug treatment of nonconvulsive seizures induced by experimental focal brain ischemia.
Topics: Amines; Animals; Anticonvulsants; Brain Infarction; Brain Injuries; Brain Ischemia; Cyclohexanecarbo | 2004 |
Relationships between glutamine, glutamate, and GABA in nerve endings under Pb-toxicity conditions.
Topics: Animals; Brain; Brain Chemistry; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Lead; Male; Rats | 2004 |
Acute desensitization of presynaptic GABAB-mediated inhibition and induction of epileptiform discharges in the neonatal rat hippocampus.
Topics: Action Potentials; Animals; Animals, Newborn; Electrophysiology; GABA Agonists; GABA Antagonists; ga | 2004 |
Epileptic-like convulsions associated with LIS-1 in the cytoskeletal control of neurotransmitter signaling in Caenorhabditis elegans.
Topics: Alleles; Amino Acid Sequence; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Codo | 2004 |
Essentiality of central GABAergic neuroactive steroid allopregnanolone for anticonvulsant action of fluoxetine against pentylenetetrazole-induced seizures in mice.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Synergism; Fluoxetine; gamma-Aminob | 2004 |
Human neural stem cell transplantation reduces spontaneous recurrent seizures following pilocarpine-induced status epilepticus in adult rats.
Topics: Aggression; Animals; Animals, Newborn; Behavior, Animal; Cell Count; Cell Death; Cells, Cultured; El | 2004 |
Behavioural correlates of an altered balance between synaptic and extrasynaptic GABAAergic inhibition in a mouse model.
Topics: Animals; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; Hippocampus; Male; Mice; | 2004 |
Bilateral microinjections of vigabatrin in the central piriform cortex retard amygdala kindling in rats.
Topics: Amygdala; Animals; Anticonvulsants; Electrodes, Implanted; Female; GABA Agonists; gamma-Aminobutyric | 2004 |
First demonstration of a functional role for central nervous system betaine/{gamma}-aminobutyric acid transporter (mGAT2) based on synergistic anticonvulsant action among inhibitors of mGAT1 and mGAT2.
Topics: Acoustic Stimulation; Acyltransferases; Amygdala; Animals; Anticonvulsants; Behavior, Animal; Cells, | 2005 |
Cefoselis, a beta-lactam antibiotic, easily penetrates the blood-brain barrier and causes seizure independently by glutamate release.
Topics: Animals; Anti-Bacterial Agents; Blood-Brain Barrier; Brain; Cefazolin; Ceftizoxime; Chromatography, | 2004 |
Mice with Ppt1Deltaex4 mutation replicate the INCL phenotype and show an inflammation-associated loss of interneurons.
Topics: Animals; Animals, Newborn; Blindness, Cortical; Cell Death; Cerebral Cortex; Disease Models, Animal; | 2005 |
Blockade of the membranal GABA transporter potentiates GABAergic responses evoked in pyramidal cells by mossy fiber activation after seizures.
Topics: Animals; Calcium Signaling; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Anta | 2005 |
Gestational and postnatal malnutrition affects sensitivity of young rats to picrotoxin and quinolinic acid and uptake of GABA by cortical and hippocampal slices.
Topics: Analysis of Variance; Animals; Animals, Newborn; Body Weight; Caseins; Cerebral Cortex; Dose-Respons | 2005 |
Effects of sodium nitroprusside, a nitric oxide donor, on gamma-aminobutyric acid concentration in the brain and on picrotoxin-induced convulsions in combination with phenobarbitone in rats.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Drug Combinations; gamma-Aminobutyric Acid; Male; | 2005 |
Effects of GABAergic transmissions on the immunoreactivities of calcium binding proteins in the gerbil hippocampus.
Topics: Animals; Baclofen; Bicuculline; Calbindin 2; Calbindins; Calcium-Binding Proteins; Cell Count; GABA | 2005 |
GABA transporter deficiency causes tremor, ataxia, nervousness, and increased GABA-induced tonic conductance in cerebellum.
Topics: Animals; Anxiety; Ataxia; Behavior, Animal; Benzodiazepines; Body Temperature; Body Weight; Cerebell | 2005 |
AMPA/kainate receptor-mediated downregulation of GABAergic synaptic transmission by calcineurin after seizures in the developing rat brain.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Blotting, Western; Calcineurin; Dos | 2005 |
Antiepileptic action induced by a combination of vigabatrin and tiagabine.
Topics: Action Potentials; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Dru | 2005 |
Study of antiepileptic effect of extracts from Acorus tatarinowii Schott.
Topics: Acorus; Animals; Anticonvulsants; Brain; Disease Models, Animal; Electroshock; Epilepsy; gamma-Amino | 2005 |
Actions at GABA(A) receptors in the hippocampus may mediate some antiseizure effects of progestins.
Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Chlorides; Disease Mo | 2005 |
GABAA receptor beta3 subunit gene-deficient heterozygous mice show parent-of-origin and gender-related differences in beta3 subunit levels, EEG, and behavior.
Topics: Angelman Syndrome; Animals; Anticonvulsants; Brain; Brain Chemistry; Disease Models, Animal; Down-Re | 2005 |
Synergistic interaction of gabapentin and oxcarbazepine in the mouse maximal electroshock seizure model--an isobolographic analysis.
Topics: Amines; Animals; Anticonvulsants; Brain; Carbamazepine; Cyclohexanecarboxylic Acids; Disease Models, | 2005 |
Genetically engineered cells with regulatable GABA production can affect afterdischarges and behavioral seizures after transplantation into the dentate gyrus.
Topics: Amino Acids; Analysis of Variance; Animals; beta-Galactosidase; Cell Line; Cell Transplantation; Chr | 2005 |
Target-specific catecholamine elevation induced by anticonvulsant thalamic deep brain stimulation.
Topics: Animals; Brain; Catecholamines; Chromatography, High Pressure Liquid; Deep Brain Stimulation; Diseas | 2005 |
Anticonvulsant effects of the wasp Polybia ignobilis venom on chemically induced seizures and action on GABA and glutamate receptors.
Topics: Amino Acids; Animals; Anticonvulsants; Behavior, Animal; Electrophoresis, Polyacrylamide Gel; Female | 2005 |
Extremely low frequency magnetic fields modulate bicuculline-induced-convulsion in rats.
Topics: Animals; Bicuculline; Brain Chemistry; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Ma | 2005 |
Anticonvulsant action of GABA in the high potassium-low magnesium model of ictogenesis in the neonatal rat hippocampus in vivo and in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Bicucu | 2005 |
The GABAergic projection of the dentate gyrus to hippocampal area CA3 of the rat: pre- and postsynaptic actions after seizures.
Topics: Animals; Dentate Gyrus; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Hippocampus; Mos | 2005 |
Gamma-aminobutyric acid and mefloquine-induced seizures in mice.
Topics: Acetanilides; Aminooxyacetic Acid; Animals; Anti-Anxiety Agents; Chi-Square Distribution; Disease Mo | 2005 |
Differential effects of mild repeated restraint stress on behaviors and GABA(A) receptors in male and female rats.
Topics: Animals; Behavior, Animal; Binding, Competitive; Cerebral Cortex; Chlorides; Corticosterone; Female; | 2005 |
Temporal patterns of fos expression in the dentate gyrus after spontaneous seizures in a mouse model of temporal lobe epilepsy.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Hi | 2005 |
Heteroaromatic side-chain analogs of pregabalin.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; gamma-A | 2006 |
Effects of carnosine on amygdaloid-kindled seizures in Sprague-Dawley rats.
Topics: Amygdala; Animals; Anticonvulsants; Carnosine; Enzyme Inhibitors; gamma-Aminobutyric Acid; Glutamic | 2005 |
Isobolographic characterisation of interactions among selected newer antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model.
Topics: Amines; Animals; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Disease Models, Animal | 2005 |
Robust estimating functions and bias correction for longitudinal data analysis.
Topics: Age Factors; Anticonvulsants; Bias; Data Interpretation, Statistical; Epilepsy; gamma-Aminobutyric A | 2005 |
Discovery of N-(2,6-dimethylphenyl)-substituted semicarbazones as anticonvulsants: hybrid pharmacophore-based design.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Benzamides; Chemical and Drug Induced Liver | 2005 |
Rearranging receptors.
Topics: Animals; Brain; Cerebellum; Child, Preschool; Disease Models, Animal; Disease Susceptibility; Epilep | 2005 |
Improving seizure control in dogs with refractory epilepsy using gabapentin as an adjunctive agent.
Topics: Amines; Animals; Anticonvulsants; Bromides; Chemotherapy, Adjuvant; Cyclohexanecarboxylic Acids; Dog | 2005 |
Activity profile of pregabalin in rodent models of epilepsy and ataxia.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug | 2006 |
Epileptogenic actions of GABA and fast oscillations in the developing hippocampus.
Topics: Aging; Animals; Animals, Newborn; Cellular Senescence; Electrophysiology; Epilepsy; GABA Antagonists | 2005 |
2,4-Dimethoxyphenylsemicarbazones with anticonvulsant activity against three animal models of seizures: synthesis and pharmacological evaluation.
Topics: Animals; Anticonvulsants; Central Nervous System; Disease Models, Animal; gamma-Aminobutyric Acid; M | 2006 |
Diphenyl diselenide and 2,3-dimercaptopropanol increase the PTZ-induced chemical seizure and mortality in mice.
Topics: Animals; Benzene Derivatives; Brain; Chelating Agents; Convulsants; Dimercaprol; Disease Models, Ani | 2006 |
Evidence that GAD65 mediates increased GABA synthesis during intense neuronal activity in vivo.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Bicuculline; Blotting, Western; Dose-Respons | 2006 |
Selective impairment of GABAergic synaptic transmission in the flurothyl model of neonatal seizures.
Topics: Animals; Animals, Newborn; Convulsants; Data Interpretation, Statistical; Excitatory Postsynaptic Po | 2006 |
Neuropharmacological effects of deltamethrin in rats.
Topics: Animals; Ataxia; Brain; Female; gamma-Aminobutyric Acid; Insecticides; Male; Molecular Structure; Ni | 2006 |
Intranigral transplants of immortalized GABAergic cells decrease the expression of kainic acid-induced seizures in the rat.
Topics: Animals; Cell Line, Transformed; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Humans; Isoenzyme | 2006 |
Evaluation of gabapentin and ethosuximide for treatment of acute nonconvulsive seizures following ischemic brain injury in rats.
Topics: Acute Disease; Amines; Animals; Brain Ischemia; Cyclohexanecarboxylic Acids; Dose-Response Relations | 2006 |
Evidence that the beta-acids fraction of hops reduces central GABAergic neurotransmission.
Topics: Animals; Antidepressive Agents; Binding, Competitive; Carbon Dioxide; Central Nervous System; Cerebe | 2007 |
Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy.
Topics: Action Potentials; Animals; Cell Line; Disease Models, Animal; Electroencephalography; Epilepsies, M | 2006 |
[Effect of chronic transauricular kindled seizures on passive-avoidance test memory retention in rats].
Topics: Animals; Avoidance Learning; gamma-Aminobutyric Acid; Hippocampus; Histamine; Kindling, Neurologic; | 2006 |
Septal GABAergic neurons are selectively vulnerable to pilocarpine-induced status epilepticus and chronic spontaneous seizures.
Topics: Analysis of Variance; Animals; Cell Survival; Disease Models, Animal; Fluoresceins; gamma-Aminobutyr | 2006 |
Mutations in the K+/Cl- cotransporter gene kazachoc (kcc) increase seizure susceptibility in Drosophila.
Topics: Animals; Chromosome Mapping; Drosophila melanogaster; gamma-Aminobutyric Acid; Genetic Predispositio | 2006 |
Substantia nigra is an anticonvulsant site of action of topiramate in the focal pilocarpine model of limbic seizures.
Topics: Animals; Anticonvulsants; Area Under Curve; Behavior, Animal; Disease Models, Animal; Dose-Response | 2006 |
Genetic interactions among cortical malformation genes that influence susceptibility to convulsions in C. elegans.
Topics: Animals; Animals, Genetically Modified; Behavior, Animal; Caenorhabditis elegans; Caenorhabditis ele | 2006 |
Design and synthesis of anticonvulsants from a combined phthalimide-GABA-anilide and hydrazone pharmacophore.
Topics: Anilides; Animals; Anticonvulsants; Disease Models, Animal; gamma-Aminobutyric Acid; Hydrazones; Mal | 2007 |
Effect of gabaergic, glutamatergic, antipsychotic and antidepressant drugs on pilocarpine-induced seizures and status epilepticus.
Topics: Amines; Amitriptyline; Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tri | 2006 |
Functional components of REM sleep programmed to exert natural anti-epileptogenic influence.
Topics: Anticonvulsants; Cell Membrane; Electroencephalography; Epilepsy; gamma-Aminobutyric Acid; Humans; M | 2007 |
Lesion of the tuberomammillary nucleus E2-region attenuates postictal seizure protection in rats.
Topics: Animals; Brain; Electroshock; Enzyme Inhibitors; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hi | 2007 |
Seizures and enhanced cortical GABAergic inhibition in two mouse models of human autosomal dominant nocturnal frontal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Electrophysiology; Epilepsy, Frontal Lobe; gamma-Aminobutyric Acid; | 2006 |
Beta/gamma oscillatory activity in the CA3 hippocampal area is depressed by aberrant GABAergic transmission from the dentate gyrus after seizures.
Topics: Animals; Biological Clocks; Dentate Gyrus; Electroencephalography; gamma-Aminobutyric Acid; Hippocam | 2007 |
Amino acid levels in some brain areas of inducible nitric oxide synthase knock out mouse (iNOS-/-) before and after pentylenetetrazole kindling.
Topics: Amino Acids; Animals; Brain; Convulsants; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Amino | 2006 |
New GABA-modulating 1,2,4-oxadiazole derivatives and their anticonvulsant activity.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Male; Models, M | 2007 |
Novel 3-iodo-8-ethoxypyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide as promising lead for design of alpha5-inverse agonist useful tools for therapy of mnemonic damage.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Ataxia; Diazepam; Drug Design; GABA Agonists; gamma-Aminobuty | 2007 |
Changes in extracellular amino acid concentrations in the rat hippocampus after in vivo actin depolymerization with latrunculin A.
Topics: Actins; Animals; Bridged Bicyclo Compounds, Heterocyclic; Excitatory Amino Acids; gamma-Aminobutyric | 2007 |
Isobolographic analysis of interaction between drugs with nonparallel dose-response relationship curves: a practical application.
Topics: Amines; Animals; Anticonvulsants; Behavior, Animal; Brain; Brain Chemistry; Cyclohexanecarboxylic Ac | 2007 |
Intraventricular administration of gabapentin in the rat increases flurothyl seizure threshold.
Topics: Amines; Animals; Anticonvulsants; Brain; Brain Chemistry; Cerebral Cortex; Convulsants; Cyclohexanec | 2007 |
Neuroimmunomodulatory effect of antibodies against GABA on acute generalized and chronic epileptiform activity.
Topics: Animals; Autoantibodies; Epilepsy; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred C57BL; Neuroimm | 2006 |
Fetal exposure to GABA-acting antiepileptic drugs generates hippocampal and cortical dysplasias.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Carbamazepine; Cerebral Cortex; Female; Fetus | 2007 |
[Effects of acute maximal electroshock and chronic transauricular kindled seizures on learning abilities in Sprague-Dawley rats].
Topics: Animals; Chronic Disease; Electric Stimulation; Electrodes; Electroshock; gamma-Aminobutyric Acid; H | 2007 |
Self-poisoning with lamotrigine and pregabalin.
Topics: Adult; Anticonvulsants; Drug Overdose; gamma-Aminobutyric Acid; Humans; Lamotrigine; Male; Pregabali | 2007 |
Optical suppression of seizure-like activity with an LED.
Topics: Animals; Anticonvulsants; Calcium; Cells, Cultured; Electrophysiology; Epilepsies, Partial; GABA Ant | 2007 |
Convulsions induced by methylmalonic acid are associated with glutamic acid decarboxylase inhibition in rats: a role for GABA in the seizures presented by methylmalonic acidemic patients?
Topics: Analysis of Variance; Animals; Baclofen; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relati | 2007 |
Transmeningeal delivery of GABA to control neocortical seizures in rats.
Topics: Acetylcholine; Analysis of Variance; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response | 2007 |
Synthesis and anticonvulsant activity of 4-(2-(2,6-dimethylphenylamino)-2-oxoethylamino)-N-(substituted)butanamides: a pharmacophoric hybrid approach.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Chemistry, Pharmaceutical; Drug Design; Ethanol; gamm | 2007 |
Central nervous system depressant activity of an ethyl acetate extract from Ipomoea stans roots.
Topics: Acetates; Animals; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; Central Nervous Syst | 2007 |
Study pharmacologic of the GABAergic and glutamatergic drugs on seizures and status epilepticus induced by pilocarpine in adult Wistar rats.
Topics: Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Excitatory Amino Acid Antagonists; Ga | 2007 |
Imperatorin enhances the protective activity of conventional antiepileptic drugs against maximal electroshock-induced seizures in mice.
Topics: Animals; Anticonvulsants; Brain; Drug Synergism; Electroshock; Furocoumarins; gamma-Aminobutyric Aci | 2007 |
Bcl-w protects hippocampus during experimental status epilepticus.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Caspase 7; Caspase 9; Cyto | 2007 |
Influence of aminophylline on the anticonvulsive action of gabapentin in the mouse maximal electroshock seizure threshold model.
Topics: Amines; Aminophylline; Animals; Anticonvulsants; Brain; Brain Chemistry; Bronchodilator Agents; Chro | 2007 |
Cocaine inhibition of GABA(A) current: role of dephosphorylation.
Topics: Animals; Calcium; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cells, Cult | 2006 |
The involvement of the substantia nigra pars reticulata in hypoglycemic seizures.
Topics: Animals; Baclofen; Behavior, Animal; Disease Models, Animal; Fasting; GABA-A Receptor Agonists; gamm | 2007 |
Hyper-beta-alaninemia associated with beta-aminoaciduria and gamma-aminobutyricaciduria, somnolence and seizures.
Topics: 4-Aminobutyrate Transaminase; Amino Acid Metabolism, Inborn Errors; beta-Alanine; Disorders of Exces | 1966 |
Pharmacological evidence for an anticonvulsant relay in the rat ventromedial medulla.
Topics: Animals; Anticonvulsants; Efferent Pathways; Female; GABA Antagonists; GABA-A Receptor Antagonists; | 2007 |
Seizure activity and changes in hippocampal extracellular glutamate, GABA, dopamine and serotonin.
Topics: Analysis of Variance; Animals; Behavior, Animal; Chromatography, Liquid; Disease Models, Animal; Dop | 2008 |
Anticonvulsive effects of intracerebroventricular administration of rutin in rats.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Dose-Response Relationship, Drug; Epilepsy, Tonic-Clon | 2008 |
Impact of receptor changes on treatment of status epilepticus.
Topics: Action Potentials; Animals; Benzodiazepines; Cholinesterase Inhibitors; Disease Models, Animal; Drug | 2007 |
Anticonvulsant characteristics of pyridoxyl-gamma-aminobutyrate, PL-GABA.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bicuculline; Drug Tolerance; Electrophysiology; | 2008 |
Altered GABAergic neurotransmission is associated with increased kainate-induced seizure in prostaglandin-endoperoxide synthase-2 deficient mice.
Topics: Analysis of Variance; Animals; Autoradiography; Celecoxib; Chromatography, High Pressure Liquid; Cyc | 2008 |
Gabapentin neuroprotection and seizure suppression in immature mouse brain ischemia.
Topics: Amines; Animals; Animals, Newborn; Anticonvulsants; Atrophy; Behavior, Animal; Body Temperature; Bra | 2008 |
Layer-specific generation and propagation of seizures in slices of developing neocortex: role of excitatory GABAergic synapses.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Afferent Pathways; Animals; Animals, Newborn; | 2008 |
Drug-induced changes in GABA content of nerve endings in 11 rat brain regions. Correlation to pharmacological effects.
Topics: Acetates; Aminooxyacetic Acid; Animals; Brain; Dose-Response Relationship, Drug; gamma-Aminobutyric | 1984 |
Protective effects of diazepam and valproate on beta-vinyllactic acid-induced seizures.
Topics: Animals; Brain; Convulsants; Diazepam; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Gl | 1984 |
Pharmacology of the GABAergic system: effects of progabide, a GABA receptor agonist.
Topics: Animals; Brain; Dopamine; gamma-Aminobutyric Acid; Humans; Norepinephrine; Receptors, Cell Surface; | 1984 |
Benzodiazepine receptor binding following amygdala-kindled convulsions: differing results in washed and unwashed brain membranes.
Topics: Amygdala; Animals; Benzodiazepinones; Brain; Buffers; Cell Membrane; Cerebral Cortex; Flunitrazepam; | 1984 |
[Neuroendocrinologic aspects of epilepsy].
Topics: Epilepsy; gamma-Aminobutyric Acid; Hippocampus; Humans; Nerve Tissue Proteins; Pyramidal Tracts; Sei | 1984 |
Modification of pyrazoloquinolinone affinity by GABA predicts efficacy at the benzodiazepine receptor.
Topics: Animals; Diazepam; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Kinetics; Male; Membra | 1984 |
Decreased convulsant potency of picrotoxin and pentetrazol and enhanced [3H]flunitrazepam cortical binding following stressful manipulations in rats.
Topics: Animals; Anti-Anxiety Agents; Cerebral Cortex; Diazepam; Flunitrazepam; GABA Antagonists; gamma-Amin | 1980 |
Audiogenic seizures: increased benzodiazepin receptor binding in a susceptible strain of mice.
Topics: Acoustic Stimulation; Animals; Anti-Anxiety Agents; Binding Sites; Brain; Diazepam; Flunitrazepam; g | 1980 |
Benzodiazepine antagonism by harmane and other beta-carbolines in vitro and in vivo.
Topics: Alkaloids; Animals; Anti-Anxiety Agents; Benzodiazepines; Brain; Carbolines; Female; gamma-Aminobuty | 1981 |
Evaluation of a synaptosomal model for monitoring in vivo changes in the GABA and glutamate content of nerve endings.
Topics: Animals; Cell Fractionation; Centrifugation, Density Gradient; Convulsants; gamma-Aminobutyric Acid; | 1981 |
Dihydropicrotoxinin binding sites in mammalian brain: interaction with convulsant and depressant benzodiazepines.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Binding, Competitive; Brain; gamma-Aminobutyric Acid; | 1981 |
Intravenous bicuculline test in mice: characterization with GABAergic drugs.
Topics: 4-Aminobutyrate Transaminase; Animals; Anti-Anxiety Agents; Benzodiazepines; Bicuculline; Female; ga | 1981 |
Behavior during hippocampal microinfusions. IV. Transmitter interactions.
Topics: Animals; Carbachol; Dose-Response Relationship, Drug; Exploratory Behavior; gamma-Aminobutyric Acid; | 1982 |
Abstinence symptoms after withdrawal of tranquillising drugs: is there a common neurochemical mechanism?
Topics: Anti-Anxiety Agents; Delirium; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Models, Biological | 1982 |
[Anxiety receptors: new pharmacological approach (author's transl)].
Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Binding, Competitive; Brain; Chlordiazepoxide; Chlo | 1982 |
Role of the relationships between the neurotransmitter systems in the convulsive-seizure reactions.
Topics: 5-Hydroxytryptophan; Amantadine; Amphetamine; Animals; Dopamine; Electroshock; gamma-Aminobutyric Ac | 1982 |
Effects of cannabidiol on behavioral seizures caused by convulsant drugs or current in mice.
Topics: Animals; Cannabidiol; Cannabinoids; Central Nervous System; Convulsants; Electroshock; GABA Antagoni | 1982 |
The effects of convulsant and anticonvulsant drugs on the release of radiolabeled GABA, glutamate, noradrenaline, serotonin and acetylcholine from rat cortical slices.
Topics: Acetylcholine; Animals; Anticonvulsants; Cerebral Cortex; Culture Techniques; Diazepam; gamma-Aminob | 1982 |
Alterations in the content of amino acid neurotransmitters before the onset and during the course of methoxypyridoxine-induced seizures in individual rabbit brain regions.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glut | 1983 |
Anticonvulsant effects of some inhibitory neurotransmitter amino acids.
Topics: Acoustic Stimulation; Amino Acids; Animals; Anticonvulsants; Electroshock; gamma-Aminobutyric Acid; | 1983 |
Differential effects of the benzodiazepine antagonist Ro 15-1788 on two types of myoclonus in baboon Papio papio.
Topics: 5-Hydroxytryptophan; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepinones; Flumazenil; g | 1983 |
Pharmacology of beta-phenylethylamine-induced seizures in mice.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Dose-Response Relationship, Drug; gamma-Aminobutyric | 1983 |
Are benzodiazepine recognition sites functional entities for the action of endogenous effector(s) or merely drug receptor(s)?
Topics: Animals; Benzodiazepinones; Brain; Flumazenil; gamma-Aminobutyric Acid; Humans; Isoniazid; Neurotran | 1983 |
Changes in regional neurotransmitter amino acid levels in rat brain during seizures induced by L-allylglycine, bicuculline, and kainic acid.
Topics: Allylglycine; Amino Acids; Animals; Aspartic Acid; Bicuculline; Brain; gamma-Aminobutyric Acid; Glut | 1984 |
Neurotransmitter abnormalities in genetically epileptic rodents.
Topics: Acoustic Stimulation; Animals; Epilepsy; gamma-Aminobutyric Acid; Mice; Mice, Mutant Strains; Neurot | 1984 |
Evidence for neurotransmitter abnormalities related to seizure activity in the epileptic baboon.
Topics: 5-Hydroxytryptophan; Acetylcholine; Amphetamine; Animals; Brain; Disease Models, Animal; Dopamine; E | 1984 |
Evidence for a role of neurotransmitters in the mechanism of topical convulsant models.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Aspartic Acid; Brain; Choline O-Acetyltransferase; Dis | 1984 |
Neurotransmitters and epilepsy: distinguishing characteristics and unifying precepts.
Topics: Animals; Brain; Disease Models, Animal; Electroshock; Epilepsy; gamma-Aminobutyric Acid; Kindling, N | 1984 |
Psychobiology of opioids.
Topics: Acetylcholine; Animals; Behavior; Brain; Brain Chemistry; Catecholamines; Circadian Rhythm; Consumma | 1984 |
GABA in brain tissue of paroxysmal (px) chick.
Topics: Animals; Brain Chemistry; Chickens; gamma-Aminobutyric Acid; Genes, Recessive; Male; Pyridoxine; Sei | 1984 |
Convulsions induced by lindane and the involvement of the GABAergic system.
Topics: Animals; Flunitrazepam; gamma-Aminobutyric Acid; Hexachlorocyclohexane; Male; Rats; Rats, Inbred Str | 1983 |
[Antiepileptic effects of complex therapy with vitamins and anticonvulsant preparations (experimental findings)].
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Drug Therapy, Com | 1982 |
[Effect of pantogam, nicotinamide, and phenazepam on seizure activity].
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Dose-Response Relationship, Drug; | 1982 |
[Participation of GABA-ergic structures in producing the effects of haloperidol].
Topics: Animals; Bicuculline; Chlorpromazine; Diazepam; gamma-Aminobutyric Acid; Haloperidol; Male; Mice; Ra | 1980 |
Effect of dopaminergic and GABA-ergic drugs given alone or in combination on the anticonvulsant action of phenobarbital and diphenylhydantoin in the electroshock test in mice.
Topics: Amantadine; Aminooxyacetic Acid; Amphetamine; Animals; Apomorphine; Baclofen; Dopamine; Electroshock | 1980 |
The role of GABA mediated neurotransmission in convulsive states.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Brain; Epilepsy; gamma-Aminobutyric Acid; Mi | 1981 |
Cefazolin experimental epilepsy: the effects of diazepam on the interictal ECoG.
Topics: Animals; Cefazolin; Chickens; Diazepam; Electroencephalography; gamma-Aminobutyric Acid; Injections, | 1980 |
Kynurenines and seizures.
Topics: Animals; Anticonvulsants; Brain; Convulsants; gamma-Aminobutyric Acid; Glycine; Kynurenine; Mice; Ra | 1981 |
An endogenous substance from porcine brain antagonizes the anticonvulsant effect of diazepam.
Topics: Animals; Anticonvulsants; Brain; Diazepam; gamma-Aminobutyric Acid; Nerve Tissue Proteins; Receptors | 1981 |
Cerebrospinal fluid GABA and cyclic nucleotides in alcoholics with and without seizures.
Topics: Alcoholism; Cyclic AMP; Cyclic GMP; gamma-Aminobutyric Acid; Humans; Seizures | 1981 |
Interactions between cholinergic drugs, gamma-aminobutyric acid and cyclic guanosine monophosphate on picrotoxin-induced convulsive-seizure threshold.
Topics: Animals; Cyclic GMP; Dibutyryl Cyclic GMP; Drug Interactions; gamma-Aminobutyric Acid; Mice; Oxotrem | 1981 |
Reversal of the antiaversive and anticonvulsant actions of diazepam, but not of progabide, by a selective antagonist of benzodiazepine receptors.
Topics: Animals; Anxiety; Benzodiazepinones; Diazepam; Flumazenil; gamma-Aminobutyric Acid; Humans; Rats; Re | 1981 |
gamma-Aminobutyric acid concentration, L-glutamate 1-decarboxylase activity, and properties of the gamma-aminobutyric and postsynaptic receptor in cobalt epilepsy in the rat.
Topics: Animals; Carboxy-Lyases; Cerebral Cortex; Cobalt; Copper; gamma-Aminobutyric Acid; Glutamate Decarbo | 1981 |
Unusual interactions of benzodiazepine receptor antagonists.
Topics: Animals; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Biological Assay; Carbolines; Flumazen | 1982 |
Specific proconvulsant action of an imidazobenzodiazepine (RO 15-1788) on isoniazid convulsions.
Topics: Animals; Benzodiazepinones; Brain; Convulsants; Drug Synergism; Flumazenil; gamma-Aminobutyric Acid; | 1982 |
Regional rat brain benzodiazepine receptor number and gamma-aminobutyric acid concentration following a convulsion.
Topics: Anesthesia; Animals; Bicuculline; Brain; Electroshock; gamma-Aminobutyric Acid; Male; Nerve Tissue P | 1982 |
gamma-Aminobutyric acid and benzodiazepine binding sites in audiogenic seizure-susceptible mice.
Topics: Acoustic Stimulation; Aging; Animals; Benzodiazepines; Brain; Cell Membrane; Flunitrazepam; gamma-Am | 1982 |
Drugs that increase gamma-aminobutyric acid transmission protect against the high pressure neurological syndrome.
Topics: Anesthetics; Animals; Bicuculline; Body Temperature; Flurazepam; gamma-Aminobutyric Acid; Male; Mice | 1982 |
Antagonism of GABA-mediated responses by d-tubocurarine in hippocampal neurons.
Topics: Animals; Bicuculline; Culture Techniques; Evoked Potentials; GABA Antagonists; gamma-Aminobutyric Ac | 1982 |
Prenatal exposure to electroconvulsive seizures and phenytoin: development of benzodiazepine binding sites, reflex behaviors and seizure thresholds in exposed offspring.
Topics: Animals; Animals, Newborn; Brain; Electroshock; Female; Fetus; gamma-Aminobutyric Acid; Phenytoin; P | 1982 |
[Convulsions induced by kynurenine and quinolinic acid as a sensitive test for assessing the anticonvulsant activity of GABA-ergic preparations].
Topics: Animals; Anticonvulsants; Drug Evaluation, Preclinical; gamma-Aminobutyric Acid; Kynurenine; Male; M | 1983 |
Synchronized burst discharge in disinhibited hippocampal slice. II. Model of cellular mechanism.
Topics: Animals; Calcium; Electric Stimulation; Evoked Potentials; gamma-Aminobutyric Acid; Guinea Pigs; Hip | 1983 |
Cyclic GMP and cyclic AMP in the cerebral cortex of mice during seizures induced by 3-mercaptopropionic acid: effects of anticonvulsant agents.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Cerebral Cortex; Cyclic AMP; Cyclic GMP; gamma-A | 1980 |
PK 8165 and PK 9084, two quinoline derivatives with anxiolytic properties, antagonize the anticonvulsant effects of diazepam.
Topics: Animals; Anticonvulsants; Benzodiazepines; Bicuculline; Brain; Diazepam; Drug Antagonism; Flunitraze | 1983 |
Kindled seizures result in decreased responsiveness of benzodiazepine receptors to gamma-aminobutyric acid (GABA).
Topics: Animals; Flunitrazepam; gamma-Aminobutyric Acid; Kindling, Neurologic; Male; Pentobarbital; Rats; Ra | 1983 |
Aminooxyacetic acid induced accumulation of GABA in the rat brain. Interaction with GABA receptors and distribution in compartments.
Topics: 3-Mercaptopropionic Acid; Acetates; Aminooxyacetic Acid; Animals; Bicuculline; Brain; Cell Compartme | 1983 |
Indirectly acting neurotoxins.
Topics: Aminolevulinic Acid; Animals; Brain; Dopamine; Estradiol; Female; gamma-Aminobutyric Acid; Lead Pois | 1983 |
Pharmacological and therapeutic actions of GABA receptor agonists.
Topics: Bipolar Disorder; Emotions; gamma-Aminobutyric Acid; Humans; Movement Disorders; Norepinephrine; Rec | 1983 |
A new model of experimental epilepsy: the cefazolin-induced epilepsy.
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Cefazolin; Chickens; Dopamine; Electrophysiology | 1983 |
Differential sensitivity of ethanol withdrawal signs in the rat to gamma-aminobutyric acid (GABA)mimetics: blockade of audiogenic seizures but not forelimb tremors.
Topics: 4-Aminobutyrate Transaminase; Acoustic Stimulation; Aminobutyrates; Animals; Chlordiazepoxide; Disea | 1983 |
Enhanced binding of radioligands to receptors of gamma-aminobutyric acid and benzodiazepine by a new anticonvulsive agent, LY81067.
Topics: Animals; Anticonvulsants; Brain; Dose-Response Relationship, Drug; Flunitrazepam; gamma-Aminobutyric | 1983 |
The interaction of the beta-carboline derivative DMCM with inhibitory amino acid responses on cultured mouse neurones.
Topics: Animals; Benzodiazepines; Carbolines; Central Nervous System; Culture Techniques; Evoked Potentials; | 1983 |
Chronic chlordiazepoxide treatment on adult and newborn rats: effect on the GABA-benzodiazepine receptor complex.
Topics: Aging; Animals; Animals, Newborn; Chlordiazepoxide; Female; Flunitrazepam; gamma-Aminobutyric Acid; | 1983 |
Phosphorus analogues of gamma-aminobutyric acid, a new class of anticonvulsants.
Topics: Animals; Anticonvulsants; Biological Assay; Brain; gamma-Aminobutyric Acid; Indicators and Reagents; | 1984 |
Increase in the Bmax of gamma-aminobutyric acid-A recognition sites in brain regions of mice receiving diazepam.
Topics: Animals; Brain; Cerebellum; Diazepam; gamma-Aminobutyric Acid; Isoniazid; Kinetics; Mice; Motor Acti | 1984 |
Intranigral muscimol suppresses ethanol withdrawal seizures.
Topics: Acoustic Stimulation; Alcoholism; Animals; gamma-Aminobutyric Acid; Humans; Male; Muscimol; Oxazoles | 1984 |
Evidence for an involvement of GABA receptors in the mediation of the proconvulsant action of ethyl-beta-carboline-3-carboxylate.
Topics: Animals; Binding Sites; Carbolines; Cerebral Cortex; Drug Synergism; gamma-Aminobutyric Acid; Hippoc | 1984 |
Ligand-binding studies on GABA receptors--relation to physiology and behavior.
Topics: Aging; Analgesia; Animals; Behavior; Brain; Cardiovascular Physiological Phenomena; Epilepsy; gamma- | 1984 |
Acute anticonvulsant activity of structural analogues of valproic acid and changes in brain GABA and aspartate content.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Aspartic Acid; Brain; Dose-Response Relationship, Dr | 1983 |
Possible mechanism of digoxin-induced convulsions.
Topics: Animals; Calcium Chloride; Clonidine; Diazepam; Digoxin; Female; gamma-Aminobutyric Acid; Magnesium; | 1983 |
Indications for the use of gamma-aminobutyric acid (GABA)-agonists in convulsant disorders.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsies, Partial; Epilepsy; gamma-Aminobutyric | 1983 |
Effect of dihydroergotoxine on the susceptibility of rats to convulsions produced by different convulsant agents.
Topics: Animals; Bicuculline; Convulsants; Dihydroergotoxine; Drug Synergism; gamma-Aminobutyric Acid; Male; | 1983 |
High anticonvulsant potency of gamma-aminobutyric acid (GABA)mimetic drugs in gerbils with genetically determined epilepsy.
Topics: Alkynes; Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Diazepam; Disease Models, An | 1983 |
The effects of analogues of valproic acid on seizures induced by pentylenetetrazol and GABA content in brain of mice.
Topics: Animals; Anticonvulsants; Brain Chemistry; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred Strains | 1983 |
Facilitation of diazepam action by anticonvulsant agents against picrotoxin induced convulsions.
Topics: Animals; Anticonvulsants; Diazepam; Female; gamma-Aminobutyric Acid; Male; Picrotoxin; Rats; Rats, I | 1983 |
[Demonstration of the correlation of the degree of synthesis and 4-aminobutyric acid levels in the central nervous system; effect of repeated convulsive seizures].
Topics: Acoustic Stimulation; Animals; Brain; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred C57BL; Mice, | 1984 |
Antiepileptic effects of amphetamine may require GABA (benzodiazepine) activity.
Topics: Amphetamine; Animals; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Female; Flumazenil; gamma | 1984 |
Amino acid metabolism in the brain with convulsive disorders. Part I: Free amino acid patterns in the brain of E1 mouse with convulsive seizure.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Brain; Cystathionine; gamma-Aminobutyric Acid; Glutami | 1984 |
Relationship between drug-induced increases of GABA levels in discrete brain areas and different pharmacological effects in rats.
Topics: Aminooxyacetic Acid; Analgesics; Animals; Body Temperature; Brain Chemistry; Female; gamma-Aminobuty | 1984 |
Lead-induced convulsions in young infants--a case history and the role of GABA and sodium valproate in the pathogenesis and treatment.
Topics: Chemical Phenomena; Chemistry; Citric Acid Cycle; gamma-Aminobutyric Acid; Humans; Infant; Lead; Lea | 1984 |
Anticonvulsant activity of 4,9-dioxo-5,10-diazatetradecane (CM 40142), a new GABA derivative, in mice and photosensitive baboons).
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Electroshock; Fem | 1984 |
GABA and neuropsychiatric disorders.
Topics: Animals; Basal Ganglia; Central Nervous System Diseases; Epilepsies, Myoclonic; Epilepsies, Partial; | 1980 |
[Further study of the antiepileptic properties of nicotinamide].
Topics: 3-Mercaptopropionic Acid; Acetylcholine; Animals; Anticonvulsants; Brain; Cats; gamma-Aminobutyric A | 1981 |
[Use of nicotinamide and pyridoxal-5-phosphate to treat experimental epilepsy].
Topics: Animals; Cats; Drug Therapy, Combination; gamma-Aminobutyric Acid; Niacinamide; Penicillins; Pyridox | 1981 |
The neuropharmacological effects of electroconvulsive shock and their relationship to the therapeutic effect of electroconvulsive therapy in depression.
Topics: Anesthesia, General; Animals; Antidepressive Agents; Apomorphine; Behavior, Animal; Brain; Corticost | 1984 |
The bicuculline-like properties of dopamine sulfate in rat brain.
Topics: Animals; Bicuculline; Brain; Diazepam; Dopamine; Drug Interactions; gamma-Aminobutyric Acid; Male; M | 1984 |
Synergistic anticonvulsant effects of a GABA agonist and glycine.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Drug Synergism; gamma-Aminobutyric Acid; Glycine | 1984 |
Synergistic effect of phosphatidylserine with gamma-aminobutyric acid in antagonizing the isoniazid-induced convulsions in mice.
Topics: Animals; Drug Synergism; Drug Therapy, Combination; gamma-Aminobutyric Acid; Isoniazid; Liposomes; L | 1984 |
Penicillin spikes in rats. Limitations of a simple model for the study of anticonvulsants.
Topics: Action Potentials; Animals; Anticonvulsants; Dimethyl Sulfoxide; Disease Models, Animal; Drug Evalua | 1984 |
gamma-Aminobutyric acid uptake inhibition and anticonvulsant activity of nipecotic acid esters.
Topics: Alanine; Animals; Anticonvulsants; Bicuculline; Chemical Phenomena; Chemistry, Physical; GABA Antago | 1984 |
An N-protected gamma-aminobutyric acid dipeptide with anticonvulsant action.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Brain; Dipeptides; gamma-Aminobutyric Acid; Kinetics; | 1984 |
Anticonvulsant activity of the nipecotic acid ester, (+/-)-m-nitrophenyl-3-piperidinecarboxylate.
Topics: Animals; Anticonvulsants; Bicuculline; gamma-Aminobutyric Acid; Isoniazid; Male; Nipecotic Acids; Pe | 1984 |
Aminooxyacetic acid provides transient protection against seizures induced by hyperbaric oxygen.
Topics: Acetates; Aminooxyacetic Acid; Animals; Anticonvulsants; Atmospheric Pressure; Brain Chemistry; Chic | 1983 |
Correlations among minimal neurotoxicity, anticonvulsant activity, and displacing potencies in [3H]flunitrazepam binding of benzodiazepines.
Topics: Animals; Benzodiazepines; Flunitrazepam; gamma-Aminobutyric Acid; Male; Mice; Nervous System; Seizur | 1983 |
Effect of phenoxybenzamine on the GABA system and on convulsive activity.
Topics: Aminooxyacetic Acid; Animals; Behavior, Animal; Brain Chemistry; Dose-Response Relationship, Drug; g | 1983 |
Anticonvulsant activity of milacemide.
Topics: Acetamides; Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Electroshock; gamma-Aminobutyri | 1983 |
An analysis of the actions of progabide, a specific GABA receptor agonist, on kindling and kindled seizures.
Topics: Amygdala; Animals; Anticonvulsants; gamma-Aminobutyric Acid; Kindling, Neurologic; Male; Rats; Rats, | 1984 |
Novel inhibitors of gamma-aminobutyric acid (GABA) uptake: anticonvulsant actions in rats and mice.
Topics: Animals; Anticonvulsants; Brain; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Ele | 1984 |
Interactions of two phenylquinolines with picrotoxin and benzodiazepines in vivo and in vitro.
Topics: Animals; Anticonvulsants; Benzodiazepines; Drug Interactions; gamma-Aminobutyric Acid; Male; Mice; M | 1984 |
The metabolic basis for the genesis of seizures: the role of the potassium-ammonia axis.
Topics: Alkalosis; Ammonia; Brain; gamma-Aminobutyric Acid; Humans; Hypokalemia; Kidney; Potassium; Seizures | 1984 |
The metabolic basis for the genesis of seizures: the role of the potassium-ammonia axis.
Topics: Alkalosis; Ammonia; Blood Urea Nitrogen; Brain; gamma-Aminobutyric Acid; Humans; Hypokalemia; Potass | 1984 |
Nigral muscimol infusions facilitate the development of seizures in immature rats.
Topics: Age Factors; Animals; Flurothyl; gamma-Aminobutyric Acid; Muscimol; Oxazoles; Rats; Seizures; Substa | 1984 |
Synaptosomal [3H]GABA uptake and [3H]nipecotic acid binding in audiogenic seizure susceptible (DBA/2) and resistant (C57 B1/6) mice.
Topics: Acoustic Stimulation; Age Factors; Animals; Cerebellum; Cerebral Cortex; gamma-Aminobutyric Acid; Mi | 1984 |
Transient seizure activity induced by acetylcarnitine.
Topics: Acetylcarnitine; Animals; Atropine; Carnitine; Cerebral Cortex; Electroencephalography; gamma-Aminob | 1984 |
Effects of the bicyclic GABA agonist, THIP, on myoclonic and seizure responses in mice and baboons with reflex epilepsy.
Topics: Animals; Anticonvulsants; Electroencephalography; gamma-Aminobutyric Acid; Haplorhini; Isoxazoles; M | 1980 |
Seizure protection and increased nerve-terminal GABA: delayed effects of GABA transaminase inhibition.
Topics: 4-Aminobutyrate Transaminase; Aminocaproates; Aminooxyacetic Acid; Animals; Brain; Cell Compartmenta | 1980 |
Activating effects of homotaurine and taurine on corticoreticular epilepsy.
Topics: Animals; beta-Alanine; Cats; Electrodes, Implanted; Electroencephalography; gamma-Aminobutyric Acid; | 1981 |
Intractable seizures: review and guide for clinical usage of valproic acid.
Topics: Child; Child, Preschool; gamma-Aminobutyric Acid; Humans; Infant; Seizures; Valproic Acid | 1981 |
Studies on gamma-aminobutyric acid transport in cobalt experimental epilepsy in the rat.
Topics: Animals; Biological Transport; Brain; Cobalt; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics | 1981 |
A comparative study of the pharmacology of inhibitors of GABA-metabolism.
Topics: 4-Aminobutyrate Transaminase; Aminooxyacetic Acid; Animals; Anticonvulsants; Electroshock; Ethanolam | 1980 |
A proposed mechanism for the anticonvulsant action of valproate.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Brain; Fatty Acids; gamma-Aminobutyric Acid; Glycoge | 1981 |
Anticonvulsant and antiaggressive properties of di-n-propyl acetate after repeated treatment.
Topics: Acoustic Stimulation; Aggression; Animals; Anticonvulsants; Brain; Female; gamma-Aminobutyric Acid; | 1982 |
A loss of GABAergic hippocampus innervation in rats with cobalt-induced epilepsy demonstrated by Wolman's fluorescence method.
Topics: Animals; Cobalt; Disease Models, Animal; Electroencephalography; Epilepsy; gamma-Aminobutyric Acid; | 1981 |
Hippocampal electrical activity and gamma-aminobutyrate metabolism in brain tissue following administration of homocysteine.
Topics: 4-Aminobutyrate Transaminase; Animals; Brain; Electrophysiology; gamma-Aminobutyric Acid; Glutamate | 1983 |
Pyridoxine-dependent seizures.
Topics: Electroencephalography; gamma-Aminobutyric Acid; Humans; Infant; Infant, Newborn; Infant, Newborn, D | 1983 |
Reduction of postsynaptic inhibition tolerated before seizure initiation: brain stem.
Topics: Animals; Bicuculline; Brain Stem; Cats; gamma-Aminobutyric Acid; Motor Neurons; Neural Inhibition; S | 1983 |
Abortive amygdaloid kindled seizures following microinjection of gamma-vinyl-GABA in the vicinity of substantia nigra in rats.
Topics: Aminocaproates; Amygdala; Animals; Brain Mapping; Feedback; gamma-Aminobutyric Acid; Kindling, Neuro | 1983 |
Inhibition of gamma-aminobutyric acid release from synaptosomes by local anesthetics.
Topics: 4-Aminobutyrate Transaminase; Anesthetics, Local; Animals; Brain; gamma-Aminobutyric Acid; Glutamate | 1983 |
Anticonvulsant activity of GABA uptake inhibitors and their prodrugs following central or systemic administration.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Body Temperature; Female; GABA Antagonists; gamma-Am | 1983 |
Cortical GABA turnover during bicuculline seizures in rats.
Topics: Aminocaproates; Animals; Bicuculline; Cerebral Cortex; gamma-Aminobutyric Acid; Male; Rats; Rats, In | 1983 |
[Convulsive syndrome in DPT vaccination (a clinico-experimental study)].
Topics: Adsorption; Animals; Central Nervous System; Child, Preschool; Diphtheria Toxoid; Drug Combinations; | 1983 |
Development of epileptic activity and its correlation with GABAergic and glutamergic systems during brain maturation in the rat.
Topics: Action Potentials; Animals; Behavior, Animal; Brain; Diazepam; Electrophysiology; gamma-Aminobutyric | 1983 |
Liposome-entrapped GABA modifies behavioral and electrographic changes of penicillin-induced epileptic activity.
Topics: Animals; Behavior, Animal; Evoked Potentials; gamma-Aminobutyric Acid; Liposomes; Penicillins; Rats; | 1982 |
Convulsions and the function of GABAergic synapses.
Topics: Aminooxyacetic Acid; Animals; Anticonvulsants; Cats; Electroshock; gamma-Aminobutyric Acid; Mice; Ph | 1980 |
Anticonvulsant effects of PGE2 on electrical, chemical and photomyoclonic animal models of epilepsy.
Topics: Animals; Anticonvulsants; Brain; Dinoprostone; Disease Models, Animal; Electric Stimulation; gamma-A | 1981 |
Pharmacological investigation of gamma-aminobutyric acid (GABA) and fully-developed generalized seizures in the amygdala-kindled rat.
Topics: Amygdala; Animals; Behavior, Animal; Drug Interactions; Electric Stimulation; Electroencephalography | 1982 |
Opiate alkaloids antagonize postsynaptic glycine and GABA responses: correlation with convulsant action.
Topics: Animals; Cells, Cultured; Dextrorphan; Enkephalin, Methionine; Enkephalins; Evoked Potentials; gamma | 1982 |
Study on hyperbaric oxygen-induced convulsion with particular reference to gamma-aminobutyric acid in synaptosomes.
Topics: Animals; Brain; gamma-Aminobutyric Acid; Hyperbaric Oxygenation; Male; Mice; Seizures; Synaptosomes | 1982 |
Protection from local anesthetic-induced convulsions by gamma-aminobutyric acid.
Topics: Anesthetics, Local; Animals; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Injections, Intra | 1982 |
Pharmacological investigation of convulsant gamma-aminobutyric acid (GABA) antagonists in amygdala-kindled rats.
Topics: Amygdala; Animals; Convulsants; Drug Synergism; GABA Antagonists; gamma-Aminobutyric Acid; Kindling, | 1982 |
Anti-convulsant characteristics of the hydroxamic acid of GABA.
Topics: Animals; Anticonvulsants; gamma-Aminobutyric Acid; Mice; Seizures | 1982 |
Relationship between GABA concentrations in cerebrospinal fluid and seizure excitability.
Topics: Animals; Dogs; Epilepsy; Female; gamma-Aminobutyric Acid; Male; Pentylenetetrazole; Seizures; Seizur | 1982 |
Cerebral glutamic acid decarboxylase activity and gamma-aminobutyric acid concentrations in mice susceptible or resistant to audiogenic seizures.
Topics: Acoustic Stimulation; Aging; Animals; Brain; Carboxy-Lyases; gamma-Aminobutyric Acid; Glutamate Deca | 1982 |
Pentylenetetrazole induced changes in cerebellar energy metabolism.
Topics: Adenosine Triphosphate; Animals; Behavior, Animal; Blood Glucose; Cerebellum; Energy Metabolism; gam | 1982 |
Anti-convulsant activity of diazepam and clonidine on metaldehyde-induced seizures in mice: effects on brain gamma-amino butyric acid concentrations and monoamine oxidase activity.
Topics: Acetaldehyde; Animals; Brain Chemistry; Clonidine; Diazepam; Female; gamma-Aminobutyric Acid; Male; | 1982 |
Substantia nigra: site of anticonvulsant activity mediated by gamma-aminobutyric acid.
Topics: Animals; Bicuculline; Brain Mapping; GABA Antagonists; gamma-Aminobutyric Acid; Male; Muscimol; Pent | 1982 |
Increase in taurine content before onset of seizures induced by a glutamate decarboxylase inhibitor.
Topics: Animals; Brain; Carboxy-Lyases; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Male; Pyridoxine; | 1982 |
Neurotoxic aspects of porphyrinopathies: lead and succinylacetone.
Topics: 5-Aminolevulinate Synthetase; Animals; Brain; gamma-Aminobutyric Acid; Heme; Heptanoates; Heptanoic | 1982 |
Central neuropharmacology of D-Ala2-Met-enkephalinamide and its interactions with taurine in rats.
Topics: Analgesia; Animals; Catatonia; Corpus Striatum; Dopamine; Endorphins; Enkephalin, Methionine; Enkeph | 1981 |
A possible neurochemical basis of the central stimulatory effects of pp'DDT.
Topics: Acetylcholine; Aminooxyacetic Acid; Ammonia; Animals; Central Nervous System; Corpus Striatum; DDT; | 1981 |
Effects of gamma-acetylenic GABA and gamma-vinyl GABA on electrically-induced spinal cord convulsions and on spinal cord GABA concentration.
Topics: Alkynes; Aminocaproates; Animals; Electroshock; Female; gamma-Aminobutyric Acid; Rats; Seizures; Spi | 1980 |
Antagonism of some central effects of d-tubocurarine by gamma-aminobutyric acid.
Topics: Animals; Decerebrate State; Female; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Injections | 1980 |
[Study of the activating effect of small doses of haloperidol].
Topics: Animals; Bicuculline; Dose-Response Relationship, Drug; Evoked Potentials; gamma-Aminobutyric Acid; | 1981 |
Anesthetic barbiturates in refractory status epilepticus.
Topics: Adult; Anticonvulsants; Brain; Female; gamma-Aminobutyric Acid; Glutamates; Humans; Injections, Intr | 1980 |
Baclofen as an anticonvulsant in experimental models of convulsions.
Topics: 3-Mercaptopropionic Acid; Acoustic Stimulation; Animals; Baclofen; Disease Models, Animal; Dose-Resp | 1981 |
On some relationships between GABA-ergic and 5-HT-ergic mechanisms in pentylenetetrazol convulsive-seizure reactions.
Topics: Animals; gamma-Aminobutyric Acid; Male; Mice; Pentylenetetrazole; Seizures; Serotonin | 1980 |
Influence of maximal audiogenic or electroshock seizures on the release of 3H-GABA from mouse brain in vitro.
Topics: Acoustic Stimulation; Animals; Brain; Electroshock; gamma-Aminobutyric Acid; In Vitro Techniques; Ma | 1981 |
[The inhibitory effect of succinic acid on the central nervous system (author's transl)].
Topics: Animals; Anticonvulsants; Body Temperature; Central Nervous System; gamma-Aminobutyric Acid; Mice; R | 1980 |
Carbohydrate metabolism in extraneural tissues in leptazol-induced convulsions & on gamma-aminobutyric acid pretreatment.
Topics: Animals; Carbohydrate Metabolism; gamma-Aminobutyric Acid; Male; Pentylenetetrazole; Rats; Seizures | 1981 |
Effect of repeated convulsive seizures on brain GABA levels.
Topics: Acoustic Stimulation; Animals; Brain; gamma-Aminobutyric Acid; Mice; Seizures; Tissue Distribution | 1981 |
Behavioural effects of GABA-agonists and antagonists infused in the mesencephalic reticular formation - deep layers of superior colliculus.
Topics: Animals; Behavior, Animal; Bicuculline; Dominance, Cerebral; gamma-Aminobutyric Acid; Mesencephalon; | 1981 |
Effect of gamma-vinyl GABA on bicuculline-induced seizures.
Topics: 4-Aminobutyrate Transaminase; Aminocaproates; Animals; Anticonvulsants; Bicuculline; Brain Chemistry | 1981 |
Dihydroergotoxine and the Seizure Threshold.
Topics: Allylglycine; Animals; Brain Chemistry; Catecholamines; Dihydroergotoxine; Drug Interactions; gamma- | 1981 |
Relationship between drug-induced changes in seizure thresholds and the GABA content of brain and brain nerve endings.
Topics: Animals; Brain Chemistry; Electroshock; gamma-Aminobutyric Acid; Male; Mice; Nerve Endings; Pentylen | 1981 |
Pharmacological investigation of gamma aminobutyric acid (GABA) and the development of amygdala-kindled seizures in the rat.
Topics: 3-Mercaptopropionic Acid; 4-Aminobutyrate Transaminase; Aminocaproates; Amygdala; Animals; Bicuculli | 1981 |
The effects of succinyl-GABA-derivatives on experimental seizures.
Topics: Animals; Blood-Brain Barrier; Brain; Dogs; gamma-Aminobutyric Acid; Rats; Seizures | 1980 |
Amygdaloid kindling and the GABA system.
Topics: 4-Aminobutyrate Transaminase; Amygdala; Animals; Electric Stimulation; Electroencephalography; Epile | 1980 |
Cetyl GABA: effect on convulsant thresholds in mice and acute toxicity.
Topics: Animals; Brain Chemistry; gamma-Aminobutyric Acid; Lethal Dose 50; Male; Mice; Pentylenetetrazole; S | 1980 |
The effects of convulsant doses of penicillin on primary afferents, dorsal root ganglion cells, and on 'presynaptic' inhibition in the spinal cord.
Topics: Afferent Pathways; Animals; Dose-Response Relationship, Drug; Evoked Potentials; gamma-Aminobutyric | 1980 |
Inhibition of kindling-induced generalized seizures by aminooxyacetic acid.
Topics: Acetates; Aminooxyacetic Acid; Amygdala; Animals; Anticonvulsants; Electric Stimulation; Electroence | 1980 |
Effects of sustained seizures produced by intrahippocampal injection of kainic acid on noradrenergic neurons: evidence for local control of norepinephrine release.
Topics: Animals; Barbiturates; Behavior, Animal; Brain Chemistry; Electroencephalography; gamma-Aminobutyric | 1980 |
Locomotor and convulsive responses to picrotoxin in amygdala-kindled rats.
Topics: Amygdala; Animals; Dose-Response Relationship, Drug; Electric Stimulation; gamma-Aminobutyric Acid; | 1980 |
Age-related differences in the effects of GABAA agonists microinjected into rat substantia nigra: pro- and anticonvulsant actions.
Topics: Age Factors; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Flurothyl; GABA Agonists; | 1995 |
Age-dependent effects of gamma-aminobutyric acid agents on flurothyl seizures.
Topics: Age Factors; Animals; Anticonvulsants; Baclofen; Convulsants; Flurothyl; GABA Agents; GABA Agonists; | 1995 |
Vigabatrin therapy in six patients with succinic semialdehyde dehydrogenase deficiency.
Topics: 4-Aminobutyrate Transaminase; Aldehyde Oxidoreductases; Brain Diseases, Metabolic; GABA Antagonists; | 1995 |
Gabapentin--a new antiepileptic drug.
Topics: Acetates; Aged; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Ami | 1994 |
Prenatal lorazepam exposure: 4. Persistent alterations in pentylenetetrazole-induced seizure threshold and GABA-dependent chloride uptake after prenatal lorazepam exposure.
Topics: Animals; Brain Chemistry; Chlorides; Chlorine; Female; gamma-Aminobutyric Acid; Lorazepam; Mice; Mus | 1995 |
Determination of amino acids and monoamine neurotransmitters in caudate nucleus of seizure-resistant and seizure-prone BALB/c mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amino Acids; Animals; Biogenic Monoamines; Caudate Nucleus; Dopamine | 1993 |
The significance of extracellular GABA in the substantia nigra of the rat during seizures and anticonvulsant treatments.
Topics: Animals; Anticonvulsants; gamma-Aminobutyric Acid; Male; Microdialysis; Pentylenetetrazole; Rats; Ra | 1995 |
Ethanol withdrawal induces increased firing in inferior colliculus neurons associated with audiogenic seizure susceptibility.
Topics: Acoustic Stimulation; Animals; Behavior, Animal; Disease Susceptibility; Ethanol; gamma-Aminobutyric | 1995 |
Effects of Tityus serrulatus crude venom on the GABAergic and dopaminergic systems of the rat brain.
Topics: Analysis of Variance; Animals; Brain; Brain Stem; Corpus Striatum; Dopamine; gamma-Aminobutyric Acid | 1994 |
4-Hydroxybutyric aciduria.
Topics: Adult; Anticonvulsants; Brain; Child; Child, Preschool; Dextromethorphan; Female; gamma-Aminobutyric | 1994 |
Further evidence for the interactions between angiotensin II and GABAergic transmission in pentylenetetrazol kindling seizures in mice.
Topics: Angiotensin II; Animals; Baclofen; Disease Models, Animal; Dose-Response Relationship, Drug; Drug In | 1995 |
Correlation between in vitro and in vivo models of proconvulsive activity with the carbapenem antibiotics, biapenem, imipenem/cilastatin and meropenem.
Topics: Analysis of Variance; Animals; Binding, Competitive; Cilastatin; Dose-Response Relationship, Drug; g | 1995 |
Simultaneous monitoring of the seizure-related changes in extracellular glutamate and gamma-aminobutyric acid concentration in bilateral hippocampi following development of amygdaloid kindling.
Topics: Amygdala; Animals; Electroencephalography; Functional Laterality; gamma-Aminobutyric Acid; Glutamic | 1995 |
GABAergic regulation of tuberoinfundibular dopaminergic neurons in the male rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Baclofen; Dopamine; GABA Agonists; GABA Antagonists; gamma- | 1994 |
Increased responsiveness of pontine reticular formation neurons associated with audiogenic seizure susceptibility during ethanol withdrawal.
Topics: Acoustic Stimulation; Alcoholic Intoxication; Alcoholism; Animals; Ethanol; gamma-Aminobutyric Acid; | 1994 |
Effects of the peptide BCH-325 upon the efficacy of common antiepileptic drugs.
Topics: Amino Acid Sequence; Animals; Anticonvulsants; Carbamazepine; Diazepam; Drug Interactions; Endorphin | 1994 |
Development of susceptibility to audiogenic seizures following cardiac arrest cerebral ischemia in rats.
Topics: Acoustic Stimulation; Animals; Brain Ischemia; Disease Susceptibility; gamma-Aminobutyric Acid; Glut | 1995 |
GABAergic and dopaminergic systems may be involved in seizures induced by pyrimethamine in mice.
Topics: Animals; Bicuculline; Diazepam; Dopamine; Drug Interactions; gamma-Aminobutyric Acid; Levodopa; Mice | 1994 |
Pyridoxine-dependent seizures associated with white matter abnormalities.
Topics: Brain; Child, Preschool; Demyelinating Diseases; gamma-Aminobutyric Acid; Humans; Male; Nerve Tissue | 1994 |
Elevated brain GABA correlates with systemic dysfunctions in paroxysmal chick.
Topics: Age Factors; Animals; Brain; Chickens; gamma-Aminobutyric Acid; Glucose; Mutation; Nerve Degeneratio | 1994 |
Successful treatment of seizures and porphyria with gabapentin.
Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyr | 1995 |
Picrotoxin and pentylene tetrazole induced seizure activity in pyridoxine-deficient rats.
Topics: Animals; Cerebral Cortex; Differential Threshold; Electroencephalography; Electronic Data Processing | 1994 |
Reduced GABA synthesis in pyridoxine-dependent seizures.
Topics: Administration, Oral; Electroencephalography; Female; Fibroblasts; gamma-Aminobutyric Acid; Genetic | 1994 |
Enhanced aspartate release related to epilepsy in (EL) mice.
Topics: Aging; Animals; Aspartic Acid; Epilepsy; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippoca | 1994 |
Further evidence of involvement of substantia nigra GABAB receptors in seizure suppression in developing rats.
Topics: Animals; Anticonvulsants; Convulsants; Flurothyl; GABA-B Receptor Antagonists; gamma-Aminobutyric Ac | 1994 |
Effect of isonicotinic acid hydrazide on extracellular amino acids and convulsions in the rat: reversal of neurochemical and behavioural deficits by sodium valproate.
Topics: Amino Acids; Animals; Aspartic Acid; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Gl | 1994 |
Altered GABAergic effects on kainic acid-induced seizures in the presence of hippocampal sclerosis in rats.
Topics: Animals; Behavior, Animal; Electrophysiology; gamma-Aminobutyric Acid; Hippocampus; Kainic Acid; Mal | 1994 |
GABA in the inferior colliculus plays a critical role in control of audiogenic seizures.
Topics: Acoustic Stimulation; Amino Acids; Animals; Baclofen; Cyclohexanecarboxylic Acids; gamma-Aminobutyri | 1994 |
Effects of endothelin-1 (ET-1) and endothelin-3 (ET-3) on convulsive seizures.
Topics: Animals; Anticonvulsants; Bicuculline; Endothelins; gamma-Aminobutyric Acid; Injections, Intraventri | 1994 |
Kindling induces time-dependent and regional specific changes in the [3H]muscimol binding in the rat hippocampus: a quantitative autoradiographic study.
Topics: Allosteric Site; Animals; Autoradiography; Electric Stimulation; gamma-Aminobutyric Acid; Hippocampu | 1994 |
gamma Aminobutyric acid mediation of the anticonvulsant effect of clonidine on pentylenetetrazol-induced seizures in mice.
Topics: Animals; Clonidine; Disease Models, Animal; gamma-Aminobutyric Acid; Mice; Pentylenetetrazole; Seizu | 1994 |
Interactions between laudanosine, GABA, and opioid subtype receptors: implication for laudanosine seizure activity.
Topics: Animals; Bicuculline; Binding, Competitive; Brain; Cell Membrane; Cerebral Ventricles; GABA Antagoni | 1994 |
Effect of GABA analogues on various components of maximum electroshock-induced seizures in mice.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Electroshock; gamma-Aminobutyric Acid; Mice; Rats; Se | 1994 |
Transmitter amino acid levels in rat brain regions after amygdala-kindling or chronic electrode implantation without kindling: evidence for a pro-kindling effect of prolonged electrode implantation.
Topics: Amino Acids; Amygdala; Animals; Aspartic Acid; Brain; Chromatography, High Pressure Liquid; Electric | 1993 |
Hippocampal changes in developing postnatal mice following intrauterine exposure to domoic acid.
Topics: Aging; Analysis of Variance; Animals; Brain; Calcium; Cerebral Cortex; Dose-Response Relationship, D | 1993 |
Transient impairment of the gabaergic function during initiation of soman-induced seizures.
Topics: Animals; Autoradiography; Brain Chemistry; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Het | 1993 |
Vigabatrin as an anticonvulsant against pentylenetetrazol seizures.
Topics: Aminocaproates; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Female; gamma-Aminobutyr | 1993 |
Vigabatrin in uncontrolled seizures: Belgian clinical experience. The Belgian Vigabatrin Evaluation Group.
Topics: Adolescent; Adult; Anticonvulsants; Belgium; Child; Child, Preschool; Dose-Response Relationship, Dr | 1994 |
Vigabatrin for refractory partial seizures in children with tuberous sclerosis.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; gamma-Aminobutyric Acid; Humans; Infant; Retro | 1994 |
The influence of thalamic GABA transmission on the susceptibility of adult rats to flurothyl induced seizures.
Topics: Aminocaproates; Animals; Anticonvulsants; Baclofen; Behavior, Animal; Bicuculline; Flurothyl; gamma- | 1993 |
Anticonvulsant doses of 2-chloro-N6-cyclopentyladenosine, an adenosine A1 receptor agonist, reduce GABAergic transmission in different areas of the mouse brain.
Topics: Adenosine; Animals; Anticonvulsants; Behavior, Animal; Brain; Bridged Bicyclo Compounds; Bridged Bic | 1993 |
Changes of extracellular GABA concentrations in the ventral hippocampus during kainate-induced seizures in rats.
Topics: Animals; Extracellular Space; gamma-Aminobutyric Acid; Hippocampus; Kainic Acid; Male; Microdialysis | 1993 |
Anticonvulsant activity of the gamma-aminobutyric acid uptake inhibitor N-4,4-diphenyl-3-butenyl-4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol .
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Dose-Response Relationship, Drug; GABA Antagonists; | 1993 |
Parvalbumin immunoreactivity in the hippocampus of the gerbil after transient forebrain ischaemia: a qualitative and quantitative sequential study.
Topics: Animals; Brain Ischemia; Cell Count; Female; gamma-Aminobutyric Acid; Gene Expression Regulation; Ge | 1993 |
Imidazenil: a new partial positive allosteric modulator of gamma-aminobutyric acid (GABA) action at GABAA receptors.
Topics: Allosteric Regulation; Animals; Benzodiazepines; Benzodiazepinones; Chloride Channels; Conflict, Psy | 1993 |
Quinolones potentiate cefazolin-induced seizures in DBA/2 mice.
Topics: Animals; Cefazolin; Drug Synergism; Electroencephalography; gamma-Aminobutyric Acid; Kinetics; Mice; | 1993 |
Inhibition of DFMO-induced audiogenic seizures by chlordiazepoxide.
Topics: Acoustic Stimulation; Animals; Brain; Chlordiazepoxide; Eflornithine; Female; gamma-Aminobutyric Aci | 1993 |
Alteration of amino acid in plasma and cerebrospinal fluid of children with seizure disorders.
Topics: Adolescent; Amino Acids; Anticonvulsants; Child; Child, Preschool; gamma-Aminobutyric Acid; Humans; | 1993 |
Experimental status epilepticus alters gamma-aminobutyric acid type A receptor function in CA1 pyramidal neurons.
Topics: Animals; Behavior, Animal; Chloride Channels; Dose-Response Relationship, Drug; Electrophysiology; F | 1995 |
Effect of alpha 2-adrenergic drugs dexmedetomidine and atipamezole on extracellular amino acid levels in vivo.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agon | 1995 |
In vivo microdialysis monitoring for extracellular glutamate and GABA in the ventral hippocampus of the awake rat during kainate-induced seizures.
Topics: Animals; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Extracellular Space; gamm | 1995 |
Gabapentin associated with aggressive behavior in pediatric patients with seizures.
Topics: Acetates; Adolescent; Age Factors; Aggression; Amines; Anticonvulsants; Child; Child Behavior Disord | 1996 |
Alpha 2-adrenoceptor agonist, dexmedetomidine, protects against kainic acid-induced convulsions and neuronal damage.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Anticonvulsants; Disease Models, A | 1995 |
Antimyoclonic effect of gabapentin in a posthypoxic animal model of myoclonus.
Topics: Acetates; Acoustic Stimulation; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; DDT; | 1996 |
Gabapentin, valproic acid, and ethanol intoxication: elevated blood levels with mild clinical effects.
Topics: Acetates; Adult; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Drug Interactions; Drug Overd | 1996 |
Accumulation of cytotoxins during the development of seizures and edema after hypoxic-ischemic injury in late gestation fetal sheep.
Topics: Animals; Aspartic Acid; Brain Edema; Brain Ischemia; Cytotoxins; Electroencephalography; Extracellul | 1996 |
Add-on gabapentin for refractory seizures in patients with brain tumours.
Topics: Acetates; Amines; Anticonvulsants; Brain Neoplasms; Cyclohexanecarboxylic Acids; Follow-Up Studies; | 1996 |
Differential effects of phenytoin and sodium valproate on seizure-induced changes in gamma-aminobutyric acid and glutamate release in vivo.
Topics: Animals; Anticonvulsants; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; Phenytoin; Ra | 1995 |
Age-specific effects of baclofen on pentylenetetrazol-induced seizures in developing rats.
Topics: Age Factors; Animals; Animals, Newborn; Baclofen; Dose-Response Relationship, Drug; Epilepsy, Tonic- | 1996 |
Seizures in a boy with succinic semialdehyde dehydrogenase deficiency treated with vigabatrin (gamma-vinyl-GABA).
Topics: 4-Aminobutyrate Transaminase; Aldehyde Oxidoreductases; Child; Enzyme Inhibitors; gamma-Aminobutyric | 1996 |
The anticonvulsant action of fluoxetine in substantia nigra is dependent upon endogenous serotonin.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anticonvulsants; Bicuculline; Convulsants; Fencloni | 1996 |
Decreased GABA effectiveness in the inferior colliculus neurons during ethanol withdrawal in rats susceptible to audiogenic seizures.
Topics: Acoustic Stimulation; Animals; Central Nervous System Depressants; Ethanol; gamma-Aminobutyric Acid; | 1996 |
Cerebrospinal fluid concentrations of glutamate and GABA during perinatal cerebral hypoxia-ischemia and seizures.
Topics: Animals; Animals, Newborn; Bicuculline; Brain Ischemia; Convulsants; gamma-Aminobutyric Acid; Glutam | 1996 |
Developmental regulation of regional functionality of substantial nigra GABAA receptors involved in seizures.
Topics: Acrylates; Animals; Bicuculline; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; GABA-A R | 1996 |
Basal expression and induction of glutamate decarboxylase and GABA in excitatory granule cells of the rat and monkey hippocampal dentate gyrus.
Topics: Animals; Basal Metabolism; Dentate Gyrus; Enzyme Induction; gamma-Aminobutyric Acid; Glutamate Decar | 1996 |
Long-term consequences of subtle stimuli during the first twenty-four hours of seizure-induced brain injury.
Topics: Acetates; Amines; Animals; Anticonvulsants; Appetitive Behavior; Brain Damage, Chronic; Cholinergic | 1996 |
Relation of the [3H] gamma-hydroxybutyric acid (GHB) binding site to the gamma-aminobutyric acidB (GABAB) receptor in rat brain.
Topics: Animals; Autoradiography; Baclofen; Benzocycloheptenes; Binding Sites; Brain; GABA Agonists; GABA An | 1996 |
Mice lacking the 65 kDa isoform of glutamic acid decarboxylase (GAD65) maintain normal levels of GAD67 and GABA in their brains but are susceptible to seizures.
Topics: Animals; Brain; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Isoenzymes; Locomotion; Mice; Mice | 1996 |
[Comparative investigation of anticonvulsive effects of putrescine and structural analogues of delta-sleep-inducing peptide].
Topics: Animals; Brain; Carnosine; Delta Sleep-Inducing Peptide; gamma-Aminobutyric Acid; Hyperbaric Oxygena | 1996 |
Vulnerability and plasticity of the GABA system in the pilocarpine model of spontaneous recurrent seizures.
Topics: Animals; Antibodies, Monoclonal; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; gam | 1996 |
Effects of some excitatory amino acid antagonists and drugs enhancing gamma-aminobutyric acid neurotransmission on pefloxacin-induced seizures in DBA/2 mice.
Topics: 4-Quinolones; Animals; Anti-Infective Agents; Anticonvulsants; Cerebral Cortex; Convulsants; Electro | 1997 |
Hippocampal and cerebellar extracellular amino acids during pilocarpine-induced seizures in freely moving rats.
Topics: Amino Acids; Animals; Aspartic Acid; Carbamazepine; Cerebellum; gamma-Aminobutyric Acid; Glutamic Ac | 1997 |
Granule cell disinhibition in dentate gyrus of genetically seizure susceptible El mice.
Topics: Aging; Animals; Anticonvulsants; Bicuculline; Chromatography, High Pressure Liquid; Dentate Gyrus; E | 1997 |
Amygdala-kindled seizures increase the expression of corticotropin-releasing factor (CRF) and CRF-binding protein in GABAergic interneurons of the dentate hilus.
Topics: Amygdala; Animals; Carrier Proteins; Cholecystokinin; Corticotropin-Releasing Hormone; Electrophysio | 1997 |
Stuttering caused by gabapentin.
Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyr | 1997 |
EEG changes induced by vigabatrin monotherapy in focal epilepsy.
Topics: 4-Aminobutyrate Transaminase; Adult; Analysis of Variance; Anticonvulsants; Case-Control Studies; El | 1997 |
Regional excitatory and inhibitory amino acid concentrations in pentylenetetrazol kindling and kindled rat brain.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Brain Chemistry; Convulsants; gamma-Aminobutyric Acid; | 1997 |
Interaction of ciprofloxacin with diclofenac and paracetamol in relation to it's epileptogenic effect.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Infective Agents; Anti-Inflammatory Agents, N | 1997 |
Effects of valproate on amino acid and monoamine concentrations in striatum of audiogenic seizure-prone Balb/c mice.
Topics: Acoustic Stimulation; Amino Acids; Animals; Anticonvulsants; Biogenic Monoamines; Corpus Striatum; D | 1996 |
A naturalistic study of the use of vigabatrin, lamotrigine and gabapentin in adults with learning disabilities.
Topics: Acetates; Adult; Aged; Amines; Anticonvulsants; Comorbidity; Cyclohexanecarboxylic Acids; Dose-Respo | 1997 |
Cocaine administration in pregnant rabbits alters cortical structure and function in their progeny in the absence of maternal seizures.
Topics: Animals; Biomarkers; Cerebral Cortex; Cocaine; Dendrites; Dose-Response Relationship, Drug; Drug Eva | 1997 |
Obstructive sleep apnoea following rapid weight gain secondary to treatment with vigabatrin (Sabril).
Topics: Adult; Anticonvulsants; Epilepsy; gamma-Aminobutyric Acid; Humans; Male; Seizures; Sleep Apnea Syndr | 1997 |
Effects of excitatory amino acid antagonists on dendrotoxin-induced increases in neurotransmitter release and epileptiform bursting in rat hippocampus in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetylcholine; Action Potentials; | 1997 |
Effects of felbamate, gabapentin and lamotrigine on seizure parameters and excitability in the rat hippocampus.
Topics: Acetates; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Dose-Response Relationship, | 1997 |
NMDA receptor-mediated pilocarpine-induced seizures: characterization in freely moving rats by microdialysis.
Topics: Animals; Anticonvulsants; Atropine; Convulsants; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; H | 1997 |
Influence of bilateral clamping of carotid arteries on the seizures susceptibility and central action of AOAA in mice.
Topics: Aminooxyacetic Acid; Animals; Anticonvulsants; Bicuculline; Brain Chemistry; Carotid Arteries; Femal | 1996 |
Topiramate enhances GABA-mediated chloride flux and GABA-evoked chloride currents in murine brain neurons and increases seizure threshold.
Topics: Animals; Anticonvulsants; Brain; Cells, Cultured; Chloride Channels; Convulsants; Drug Synergism; Fl | 1997 |
Generalised seizure-induced changes in rat hippocampal glutamate but not GABA release are potentiated by repeated seizures.
Topics: Analysis of Variance; Animals; Electroshock; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Ma | 1997 |
Analysis of overdispersed count data by mixtures of Poisson variables and Poisson processes.
Topics: Anticonvulsants; Biometry; Epilepsy; gamma-Aminobutyric Acid; Humans; Likelihood Functions; Normal D | 1997 |
The novel anticonvulsant, gabapentin, protects against both convulsant and anxiogenic aspects of the ethanol withdrawal syndrome.
Topics: Acetates; Amines; Animals; Anticonvulsants; Ataxia; Behavior, Animal; Cyclohexanecarboxylic Acids; E | 1997 |
The effect of GABAergic system activity on hyperthermia-induced seizures in rats.
Topics: Analysis of Variance; Animals; Bicuculline; Body Temperature Regulation; Electroencephalography; Fem | 1997 |
Seizure suppression in kindling epilepsy by grafts of fetal GABAergic neurons in rat substantia nigra.
Topics: Animals; Brain Tissue Transplantation; Cell Transplantation; Female; Fetal Tissue Transplantation; g | 1998 |
Time-dependent and regional expression of GABA transporter mRNAs following amygdala-kindled seizures in rats.
Topics: Amygdala; Animals; Carrier Proteins; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Aci | 1998 |
[Possible role of nitric oxide in pathogenesis of model seizure of the different etiology].
Topics: Animals; Brain; Convulsants; Electron Spin Resonance Spectroscopy; Electroshock; Excitatory Amino Ac | 1998 |
Vigabatrin: placental transfer in vivo and excretion into breast milk of the enantiomers.
Topics: Adult; Anticonvulsants; Central Nervous System; Female; Fetal Blood; gamma-Aminobutyric Acid; Humans | 1998 |
Anticonvulsant action of gabapentin during postnatal development in rats.
Topics: Acetates; Amines; Animals; Anticonvulsants; Behavior, Animal; Brain; Cyclohexanecarboxylic Acids; Do | 1997 |
Increased seizure frequency associated with felbamate withdrawal in adults.
Topics: Acetates; Adult; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Felbamate; Gabapentin; gamma- | 1998 |
Gabapentin potentiation of the antiepileptic efficacy of vigabatrin in an in vitro model of epilepsy.
Topics: 4-Aminobutyrate Transaminase; Acetates; Amines; Animals; Anticonvulsants; Bicuculline; Cyclohexaneca | 1998 |
Extracellular amino acids in the rat hippocampus during picrotoxin threshold seizures in chronic microdialysis experiments.
Topics: Amino Acids; Animals; Aspartic Acid; Electroencephalography; Extracellular Space; gamma-Aminobutyric | 1998 |
Gabapentin potentiates the antiseizure activity of certain anticonvulsants in DBA/2 mice.
Topics: Acetates; Acoustic Stimulation; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Drug | 1998 |
Changes in extracellular glutamate and GABA levels in the hippocampal CA3 and CA1 areas and the induction of glutamic acid decarboxylase-67 in dentate granule cells of rats treated with kainic acid.
Topics: Analysis of Variance; Animals; Diazepam; Enzyme Induction; gamma-Aminobutyric Acid; Glutamate Decarb | 1998 |
Influence of intracerebroventricular administration of tetanus toxin on experimental seizures and protection afforded by some antiepileptic drugs in mice.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Drug Synergism; gamma-Aminobutyric Acid; Glutamate Dec | 1998 |
Validation of corneally kindled mice: a sensitive screening model for partial epilepsy in man.
Topics: Amygdala; Animals; Anticonvulsants; Carbamazepine; Cornea; Disease Models, Animal; Dizocilpine Malea | 1998 |
Protective effect of clozapine against pentylenetetrazol convulsions and kindling.
Topics: Animals; Antipsychotic Agents; Clozapine; Female; gamma-Aminobutyric Acid; Kindling, Neurologic; Mal | 1998 |
Behavioral effects of vigabatrin correlated with whole brain gamma-aminobutyric acid metabolism in audiogenic sensitive rats.
Topics: 4-Aminobutyrate Transaminase; Acoustic Stimulation; Animals; Anticonvulsants; Behavior, Animal; Brai | 1998 |
Suppression of elevated alanine aminotransferase activity in liver disease by vigabatrin.
Topics: Alanine Transaminase; Anticonvulsants; Diffuse Cerebral Sclerosis of Schilder; Enzyme Inhibitors; Fa | 1998 |
Anticonvulsant effect of progabide in rats during ontogenesis.
Topics: Aging; Animals; Anticonvulsants; Behavior, Animal; Convulsants; gamma-Aminobutyric Acid; Male; Penty | 1997 |
Anticonvulsant effect of SL 75 102 in adult and immature rats.
Topics: Aging; Animals; Anticonvulsants; gamma-Aminobutyric Acid; Pentylenetetrazole; Rats; Seizures | 1997 |
Pharmacological evidence for GABAergic and glutamatergic involvement in the convulsant and behavioral effects of glutaric acid.
Topics: Animals; Behavior, Animal; Convulsants; Corpus Striatum; Dizocilpine Maleate; Dose-Response Relation | 1998 |
Immunohistochemical evidence for dysregulation of the GABAergic system ipsilateral to photochemically induced cortical infarcts in rats.
Topics: Animals; Brain Ischemia; Cerebral Infarction; Dominance, Cerebral; gamma-Aminobutyric Acid; Gene Exp | 1998 |
Mediodorsal thalamus plays a critical role in the development of limbic motor seizures.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Bicuculline; Brain Mapping; Carbon Radioisoto | 1998 |
Seizure sensitivity and GABAergic modulation of ethanol sensitivity in selectively bred FAST and SLOW mouse lines.
Topics: Animals; Baclofen; Ethanol; GABA Modulators; gamma-Aminobutyric Acid; Genetic Predisposition to Dise | 1998 |
Prenatal stress reduces the effectiveness of the neurosteroid 3 alpha,5 alpha-THP to block kainic-acid-induced seizures.
Topics: Analysis of Variance; Animals; Anticonvulsants; Corticosterone; Female; gamma-Aminobutyric Acid; Hip | 1999 |
Gamma-aminobutyric acid and glutamic acid receptors may mediate theophylline-induced seizures in mice.
Topics: 2-Amino-5-phosphonovalerate; Aminobutyrates; Aminooxyacetic Acid; Animals; Baclofen; Bicuculline; Cl | 1999 |
Characterization of the electrophysiological and pharmacological effects of 4-iodo-2,6-diisopropylphenol, a propofol analogue devoid of sedative-anaesthetic properties.
Topics: Acetylcholine; Anesthetics; Animals; Anti-Anxiety Agents; Anticonvulsants; Chloride Channels; Confli | 1999 |
In vivo and in vitro toxicodynamic analyses of new quinolone-and nonsteroidal anti-inflammatory drug-induced effects on the central nervous system.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Central Nervous System; Dose-Response Relationship | 1999 |
Ultrastructure and immunocytochemical distribution of GABA in layer III of the rat medial entorhinal cortex following aminooxyacetic acid-induced seizures.
Topics: Aminooxyacetic Acid; Animals; Entorhinal Cortex; gamma-Aminobutyric Acid; Immunohistochemistry; Male | 1999 |
SPD 502: a water-soluble and in vivo long-lasting AMPA antagonist with neuroprotective activity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Binding, Competiti | 1999 |
Effects of diazepam on extracellular brain neurotransmitters in pilocarpine-induced seizures in rats.
Topics: Animals; Behavior, Animal; Brain; Cerebellum; Diazepam; Dopamine; Electroencephalography; Extracellu | 1999 |
[Lidocaine increases the granule cell excitability in hippocampal dentate area instead of affecting GABAergic inhibition].
Topics: Action Potentials; Anesthetics, Local; Animals; Dentate Gyrus; gamma-Aminobutyric Acid; Lidocaine; M | 1999 |
Proconvulsive effect of tea (Camellia sinensis) in mice.
Topics: Animals; Brain Chemistry; Caffeine; Convulsants; Electroshock; Female; gamma-Aminobutyric Acid; Male | 1999 |
Action of bicyclic isoxazole GABA analogues on GABA transporters and its relation to anticonvulsant activity.
Topics: Animals; Animals, Newborn; Anticonvulsants; Astrocytes; Cells, Cultured; Embryo, Mammalian; gamma-Am | 1999 |
Quantal GABA release: noise or not?
Topics: Animals; gamma-Aminobutyric Acid; Seizures; Synapses | 1999 |
Hypothermia ameliorates ischemic brain damage and suppresses the release of extracellular amino acids in both normo- and hyperglycemic subjects.
Topics: Animals; Brain; Brain Ischemia; Corpus Striatum; Disease Models, Animal; Excitatory Amino Acids; Ext | 1999 |
Regulation of limbic motor seizures by GABA and glutamate transmission in nucleus tractus solitarius.
Topics: Animals; Bicuculline; Electric Stimulation Therapy; Excitatory Amino Acid Antagonists; GABA Agonists | 1999 |
Synaptically released glutamate reduces gamma-aminobutyric acid (GABA)ergic inhibition in the hippocampus via kainate receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; GABA-B | 1999 |
Inhibition of GABA system involved in cyclosporine-induced convulsions.
Topics: Animals; Anticonvulsants; Bicuculline; Binding Sites; Brain; Cells, Cultured; Cerebellum; Cyclospori | 1999 |
Effects of anticonvulsant lactams on in vitro seizures in the hippocampal slice preparation.
Topics: 4-Butyrolactone; Animals; Anticonvulsants; Calcium Channel Blockers; Electrophysiology; gamma-Aminob | 1999 |
Synthesis of novel GABA uptake inhibitors. 4. Bioisosteric transformation and successive optimization of known GABA uptake inhibitors leading to a series of potent anticonvulsant drug candidates.
Topics: Animals; Anticonvulsants; Female; gamma-Aminobutyric Acid; In Vitro Techniques; Neurotransmitter Upt | 1999 |
Synchronization of GABAergic interneuronal networks during seizure-like activity in the rat horizontal hippocampal slice.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Elect | 1999 |
In vitro and in vivo characterization of conantokin-R, a selective NMDA receptor antagonist isolated from the venom of the fish-hunting snail Conus radiatus.
Topics: Animals; Anticonvulsants; Behavior, Animal; Binding, Competitive; Cerebral Cortex; Conotoxins; Dizoc | 2000 |
Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A).
Topics: Animals; Brain; Endocrine System; gamma-Aminobutyric Acid; Genes, Lethal; Hippocampus; Homozygote; M | 1999 |
Effects of diazepam or haloperidol on convulsion and behavioral responses induced by bilateral electrical stimulation in the medial prefrontal cortex.
Topics: Animals; Anti-Dyskinesia Agents; Anticonvulsants; Diazepam; Electric Stimulation; gamma-Aminobutyric | 1999 |
Selective susceptibility to inhibitors of GABA synthesis and antagonists of GABA(A) receptor in rats with genetic absence epilepsy.
Topics: 3-Mercaptopropionic Acid; Animals; Bicuculline; Carbolines; Convulsants; Electroencephalography; Epi | 2000 |
Neocortical hyperexcitability after GABA withdrawal in vitro.
Topics: Animals; Flunitrazepam; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Muscimol; Neocortex | 2000 |
Effect of gastrin-releasing peptide on rat hippocampal extracellular GABA levels and seizures in the audiogenic seizure-prone DBA/2 mouse.
Topics: Animals; Dose-Response Relationship, Drug; Epilepsy, Reflex; Extracellular Space; gamma-Aminobutyric | 2000 |
Synthesis and anticonvulsant and neurotoxic properties of substituted N-phenyl derivatives of the phthalimide pharmacophore.
Topics: Administration, Oral; Animals; Anticonvulsants; Batrachotoxins; Cerebral Cortex; Convulsants; Electr | 2000 |
Central action of some cytostatics--methotrexate (MTX) and doxorubicin (DXR). II. The influence on the seizure activity and the learning and memory processes in mice.
Topics: Animals; Brain; Doxorubicin; Drug Interactions; Female; gamma-Aminobutyric Acid; Hexobarbital; Learn | 1998 |
Topiramate modulates GABA-evoked currents in murine cortical neurons by a nonbenzodiazepine mechanism.
Topics: Action Potentials; Animals; Anticonvulsants; Cells, Cultured; Cerebral Cortex; Clonazepam; Evoked Po | 2000 |
Anticonvulsant efficacy of gabapentin and levetiracetam in phenytoin-resistant kindled rats.
Topics: Acetates; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Drug Evaluation; Drug Resis | 2000 |
Effects of L-arginine on picrotoxin-induced increase in brain ammonia concentrations and convulsions in rats.
Topics: Ammonia; Animals; Anticonvulsants; Arginine; Brain; Brain Stem; Cerebellum; Cerebral Cortex; Diazepa | 1999 |
Guanosine and GMP prevent seizures induced by quinolinic acid in mice.
Topics: Animals; Anticonvulsants; Central Nervous System; Dose-Response Relationship, Drug; Drug Interaction | 2000 |
Postnatal development of a GABA deficit and disturbance of neural functions in mice lacking GAD65.
Topics: Age Factors; Aggression; Animals; Anxiety; Aspartic Acid; Brain; Brain Chemistry; Circadian Rhythm; | 2000 |
Prenatal morphine exposure alters susceptibility to bicuculline seizures in a sex- and age-specific manner.
Topics: Age Factors; Analgesics, Opioid; Animals; Bicuculline; Convulsants; Disease Susceptibility; Epilepsy | 2000 |
Effects of ammonia on pentylenetetrazole-induced seizure threshold.
Topics: Ammonia; Animals; Aspartic Acid; Brain; Dose-Response Relationship, Drug; Drug Interactions; gamma-A | 1999 |
GABA-transaminase antisense oligodeoxynucleotide modulates cocaine- and pentylenetetrazol-induced seizures in mice.
Topics: 4-Aminobutyrate Transaminase; Animals; Brain; Cerebral Ventricles; Cocaine; Convulsants; Dopamine Up | 1999 |
Participation of GABAergic and histaminergic systems in inhibiting amygdaloid kindled seizures.
Topics: Amygdala; Animals; Bicuculline; Diazepam; gamma-Aminobutyric Acid; Histamine; Imidazoles; Kindling, | 2000 |
Gabapentin in seizures due to acute intermittent porphyria.
Topics: Acetates; Adult; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Ami | 2000 |
The effects of gabapentin in the rat hippocampus are mimicked by two structural analogs, but not by nimodipine.
Topics: Acetates; Amines; Animals; Anticonvulsants; Calcium Channel Blockers; Cyclohexanecarboxylic Acids; C | 2000 |
The effect of CGP-40116 on pilocarpine evoked seizures in mice exposed to transient episode of brain ischemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Behavior, Animal; Brain; Brain Chemistry; Car | 2000 |
Proconvulsive effects of the mitochondrial respiratory chain inhibitor--3-nitropropionic acid.
Topics: Acetylcholine; Animals; Convulsants; Drug Interactions; Electric Stimulation; Electron Transport; El | 2000 |
GABA-level increasing and anticonvulsant effects of three different GABA uptake inhibitors.
Topics: Acoustic Stimulation; Anesthesia; Animals; Anisoles; Anticonvulsants; Carbazoles; Chromatography, Hi | 2000 |
Unit-treatment interaction and its practical consequences.
Topics: Analysis of Variance; Anticonvulsants; Clinical Trials as Topic; Epilepsy; gamma-Aminobutyric Acid; | 2000 |
4-Hydroxybenzaldehyde from Gastrodia elata B1. is active in the antioxidation and GABAergic neuromodulation of the rat brain.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Benzaldehydes; Brain; Convulsants; gamma-Ami | 2000 |
The influence of MK-801 on bicuculline evoked seizures in adult mice exposed to transient episode of brain ischemia.
Topics: Age Factors; Animals; Behavior, Animal; Bicuculline; Brain Chemistry; Convulsants; Dizocilpine Malea | 2000 |
Anticonvulsant action and long-term effects of gabapentin in the immature brain.
Topics: Acetates; Amines; Animals; Anticonvulsants; Behavior, Animal; Brain; Convulsants; Cyclohexanecarboxy | 2001 |
Sodium valproate alters GnRH-GABA interactions during development in seizure-prone mice.
Topics: Animals; Anticonvulsants; gamma-Aminobutyric Acid; Gonadotropin-Releasing Hormone; Humans; Male; Mic | 2000 |
Seizures induce simultaneous GABAergic and glutamatergic transmission in the dentate gyrus-CA3 system.
Topics: Amygdala; Animals; Dentate Gyrus; Electric Stimulation; Electrodes, Implanted; Epilepsy; Evoked Pote | 2000 |
Phenotypic expression of the systemic toxicity of cocaine in genetically epilepsy-prone rats.
Topics: Animals; Arrhythmias, Cardiac; Cocaine; Electroencephalography; Epilepsy; gamma-Aminobutyric Acid; G | 2000 |
Seizures and neurodegeneration induced by 4-aminopyridine in rat hippocampus in vivo: role of glutamate- and GABA-mediated neurotransmission and of ion channels.
Topics: 4-Aminopyridine; Animals; Epilepsy; Excitatory Amino Acid Antagonists; GABA Agonists; GABA Antagonis | 2000 |
Collapse of extracellular glutamate regulation during epileptogenesis: down-regulation and functional failure of glutamate transporter function in rats with chronic seizures induced by kainic acid.
Topics: Amino Acid Transport System X-AG; Animals; ATP-Binding Cassette Transporters; Carrier Proteins; Chro | 2001 |
Swim stress alters the behavioural response of mice to GABA-related and some GABA-unrelated convulsants.
Topics: Animals; Behavior, Animal; Convulsants; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; I | 2001 |
Activation of neostriatal dopaminergic system in rats prevents toxic effects of picrotoxin administered into globus pallidus.
Topics: Amphetamine; Animals; Dopamine; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Globus Pallidu | 2000 |
Kainate receptors keep the excitement high.
Topics: Animals; Anticonvulsants; Convulsants; gamma-Aminobutyric Acid; Hippocampus; Humans; Kainic Acid; Py | 2001 |
Changes in striatal electroencephalography and neurochemistry induced by kainic acid seizures are modified by dopamine receptor antagonists.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aspartic Acid; Benzazepines; Corpus Striatum; Dopamine; Dop | 2001 |
CSF glutamate/GABA concentrations in pyridoxine-dependent seizures: etiology of pyridoxine-dependent seizures and the mechanisms of pyridoxine action in seizure control.
Topics: gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Humans; Infant; Male; Pyridoxine; S | 2001 |
Inhibitory effect of theophylline on recombinant GABA(A) receptor.
Topics: Animals; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; Gene Expression; Ion Cha | 2001 |
Overexpression of gamma-aminobutyric acid transporter subtype I leads to susceptibility to kainic acid-induced seizure in transgenic mice.
Topics: Action Potentials; Amino Acid Transport System X-AG; Animals; ATP-Binding Cassette Transporters; Bra | 2001 |
2-chloro-N(6)-cyclopentyladenosine-elicited attenuation of evoked glutamate release is not sufficient to give complete protection against pilocarpine-induced seizures in rats.
Topics: Adenosine; Animals; Behavior, Animal; Dopamine; Electroencephalography; Electrophysiology; gamma-Ami | 2001 |
AIT-082 is neuroprotective against kainate-induced neuronal injury in rats.
Topics: Aminobenzoates; Analysis of Variance; Animals; Cell Survival; Dentate Gyrus; Diazepam; Electroenceph | 2001 |
Protective role of ATP-sensitive potassium channels in hypoxia-induced generalized seizure.
Topics: Adenosine Triphosphate; Animals; Electroencephalography; Electromyography; Excitatory Amino Acid Ant | 2001 |
Whole-cell but not acellular pertussis vaccines induce convulsive activity in mice: evidence of a role for toxin-induced interleukin-1beta in a new murine model for analysis of neuronal side effects of vaccination.
Topics: Animals; Bordetella pertussis; Brain; Disease Models, Animal; Female; Fever; gamma-Aminobutyric Acid | 2001 |
Synthesis of novel gamma-aminobutyric acid (GABA) uptake inhibitors. 5.(1) Preparation and structure-activity studies of tricyclic analogues of known GABA uptake inhibitors.
Topics: Animals; Anticonvulsants; Antidepressive Agents, Tricyclic; Brain Chemistry; Carbolines; Convulsants | 2001 |
Epileptogenesis and enhanced prepulse inhibition in GABA(B1)-deficient mice.
Topics: Action Potentials; Animals; Baclofen; Behavior, Animal; Central Nervous System; Down-Regulation; Epi | 2001 |
Anticonvulsant efficacy of gabapentin on kindling in the immature brain.
Topics: Acetates; Age Factors; Amines; Amygdala; Animals; Anticonvulsants; Behavior, Animal; Brain; Child; C | 2001 |
Inhibition of the substantia nigra suppresses absences and clonic seizures in audiogenic rats, but not tonic seizures: evidence for seizure specificity of the nigral control.
Topics: Acoustic Stimulation; Animals; Auditory Pathways; Electroencephalography; Epilepsy, Absence; Epileps | 2001 |
Evidence for an involvement of the ammonia-decreasing action of L-arginine in suppressing picrotoxin-induced convulsions in rats and its additive action with diazepam.
Topics: Ammonia; Animals; Arginine; Brain; Diazepam; Drug Interactions; Epilepsy; GABA Antagonists; GABA Mod | 2001 |
Effect of alkylpyrazine derivatives on the duration of pentobarbital-induced sleep, picrotoxicin-induced convulsion and gamma-aminobutyric acid (GABA) levels in the mouse brain.
Topics: Aminooxyacetic Acid; Animals; Anticonvulsants; Bicuculline; Brain Chemistry; Convulsants; Diazepam; | 2001 |
Single systemic dose of vigabatrin induces early proconvulsant and later anticonvulsant effect in rats.
Topics: Action Potentials; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Dru | 2001 |
Seizures induced by intracerebral administration of pyridoxal-5'-phosphate: effect of GABAergic drugs and glutamate receptor antagonists.
Topics: Animals; Electroencephalography; Excitatory Amino Acid Antagonists; GABA Agents; gamma-Aminobutyric | 2001 |
Synthesis of novel GABA uptake inhibitors. Part 6: preparation and evaluation of N-Omega asymmetrically substituted nipecotic acid derivatives.
Topics: Animals; Disease Models, Animal; Ethers; GABA Antagonists; gamma-Aminobutyric Acid; Inhibitory Conce | 2001 |
Testosterone reduces pentylenetetrazole-induced ictal activity of wildtype mice but not those deficient in type I 5alpha-reductase.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Animals; Brain; Convulsants; Epilepsy; Female; gamma-Aminobut | 2001 |
Gabapentin for clozapine-related seizures.
Topics: Acetates; Aged; Amines; Antimanic Agents; Antipsychotic Agents; Clozapine; Cyclohexanecarboxylic Aci | 2001 |
Sexual dimorphism and developmental regulation of substantia nigra function.
Topics: Aging; Animals; Animals, Newborn; Castration; Convulsants; Disease Susceptibility; Female; GABA Agon | 2001 |
Ovariectomy aggravates convulsions and hippocampal gamma-aminobutyric acid inhibition induced by cyclosporin A in rats.
Topics: Aminooxyacetic Acid; Animals; Antirheumatic Agents; Cyclosporine; Dose-Response Relationship, Drug; | 2001 |
The effects of N-methyl-D-aspartate antagonist 2-amino-7-phosphonoheptanoic acid microinfusions into the adult male rat substantia nigra pars reticulata are site-specific.
Topics: 2-Amino-5-phosphonovalerate; Animals; Convulsants; Dose-Response Relationship, Drug; Excitatory Amin | 2001 |
Prenatal morphine exposure decreases susceptibility of adult male rat offspring to bicuculline seizures.
Topics: Animals; Bicuculline; Brain; Disease Susceptibility; Epilepsy; Female; GABA Antagonists; gamma-Amino | 2001 |
Selection effects in randomized trials with count data.
Topics: Anticonvulsants; Computer Simulation; Electrocardiography, Ambulatory; Epilepsy; gamma-Aminobutyric | 2002 |
The effects of neuroleptics on the GABA-induced Cl- current in rat dorsal root ganglion neurons: differences between some neuroleptics.
Topics: Animals; Antipsychotic Agents; Cells, Cultured; Chloride Channel Agonists; Chloride Channels; Clozap | 2002 |
Attenuating effects of melatonin on pilocarpine-induced seizures in rats.
Topics: Age Factors; Animals; Anticonvulsants; Female; gamma-Aminobutyric Acid; Melatonin; N-Methylscopolami | 2002 |
[Inhibitory processes in the cerebral cortex and the anticonvulsive action of benzodiazepine derivatives].
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Brain; Cats; Cerebral Cortex; Clonazepam; Diazepam; E | 1977 |
On some relationships between gamma-aminobutyric acid (GABA) and the cholinergic mechanisms in electric convulsions.
Topics: Aminobutyrates; Animals; Arecoline; Diphenylacetic Acids; Electric Stimulation; gamma-Aminobutyric A | 1977 |
An experimental model to investigate disinhibitory mechanisms in penicillin epileptogenesis.
Topics: Animals; beta-Alanine; Cats; gamma-Aminobutyric Acid; Glycine; Homocysteine; Iontophoresis; Neurotra | 1978 |
A synthetic non-benzodiazepine ligand for benzodiazepine receptors: a probe for investigating neuronal substrates of anxiety.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Body Temperature; Conflict, Psychological; g | 1979 |
Effects of some anti-epileptic, neuroleptic and gabaminergic drugs on convulsions induced by D,L-allylglycine.
Topics: Allylglycine; Animals; Anticonvulsants; Antipsychotic Agents; gamma-Aminobutyric Acid; Glycine; Male | 1979 |
Seizure proneness and neurotransmitter uptake.
Topics: Animals; Biological Transport; Choline; Dopamine; gamma-Aminobutyric Acid; Glutamates; Glycine; Mese | 1979 |
Convulsive properties of lindane, lindane metabolites, and the lindane isomer alpha-hexachlorocyclohexane: effects on the convulsive threshold for pentylenetetrazol and the brain content of gamma-aminobutyric acid (GABA) in the mouse.
Topics: Animals; Brain; Brain Chemistry; Female; gamma-Aminobutyric Acid; Hexachlorocyclohexane; Mice; Penty | 1978 |
Effects of changes in cortical excitability upon the epileptic bursts in generalized penicillin epilepsy of the cat.
Topics: Adenosine Monophosphate; Animals; Barbiturates; Cats; Central Nervous System Depressants; Cerebral C | 1979 |
Involvement of gamma-amino butyric acid (GABA) in the anticonvulsant action of methaqualone.
Topics: Aminobutyrates; Animals; Anticonvulsants; Brain Chemistry; Cerebellum; Diazepam; gamma-Aminobutyric | 1978 |
Blockade of epileptic responses in the photosensitive baboon, Papio papio, by two irreversible inhibitors of GABA-transaminase, gamma-acetylenic GABA (4-amino-hex-5-ynoic acid) and gamma-vinyl GABA (4-amino-hex-5-enoic acid).
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Behavior, Animal; Electroencephalography; Fe | 1978 |
Effect of amino-oxyacetic acid (AOAA) on focal penicillin seizures.
Topics: Acetates; Alanine; Aminooxyacetic Acid; Animals; Aspartic Acid; Cerebral Cortex; Disease Models, Ani | 1978 |
Low cerebrospinal fluid gamma-aminobutyric acid content in seizure patients.
Topics: Adult; Epilepsy; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Clonic; Female; gamma-Aminobutyric Acid; H | 1979 |
A pharmacological study of the spontaneous convulsive activity induced by 1,2-dihydroxybenzene (catechol) in the anaesthetized mouse.
Topics: Acetylcholine; Anesthesia; Animals; Atropine; Catechols; Female; gamma-Aminobutyric Acid; Male; Mice | 1977 |
On certain relationships between gamma-aminobutyric acid (GABA) and adrenergic mechanisms in convulsive-seizure reaction.
Topics: Aminobutyrates; Animals; Ditiocarb; Electroshock; gamma-Aminobutyric Acid; Injections, Intraventricu | 1976 |
Effects of gaba, gabob and some anticonvulsant drugs on dibutyryl cyclic AMP evoked seizures.
Topics: Aminobutyrates; Animals; Anticonvulsants; Bucladesine; Chickens; Diazepam; Electroencephalography; F | 1977 |
Effects of certain drugs connected with the system of 3',5'-cAMP on the picrotoxin convulsive-seizure threshold and on the action of GABA.
Topics: Aminobutyrates; Animals; Brain; Bucladesine; Cyclic AMP; Drug Interactions; gamma-Aminobutyric Acid; | 1976 |
Effect of isopropylnoradrenaline, adenosine, cyclic 3',5'-adenosinemonosphosphate and dibutyryl cyclic adenosinemonophosphate on the picrotoxin convulsive-seizure threshold. Interaction with gamma-aminobutyric acid.
Topics: Adenosine; Aminobutyrates; Animals; Bucladesine; Cyclic AMP; Drug Interactions; gamma-Aminobutyric A | 1976 |
Effect of combined dopaminergic and GABA-ergic stimulation on ouabain-induced epileptiform activity.
Topics: Aminooxyacetic Acid; Animals; Apomorphine; Cerebral Cortex; Drug Combinations; Drug Synergism; Elect | 1977 |
Metabolite levels in brain following experimental seizures: the effects of maximal electroshock and phenytoin in cerebellar layers.
Topics: Adenosine Triphosphate; Animals; Brain; Cyclic AMP; Cyclic GMP; Electroshock; gamma-Aminobutyric Aci | 1979 |
Metabolite levels in brain following experimental seizures: the effects of isoniazid and sodium valproate in cerebellar and cerebral cortical layers.
Topics: Animals; Brain; Cerebellum; Cerebral Cortex; Cyclic AMP; Cyclic GMP; gamma-Aminobutyric Acid; Glucos | 1979 |
Photosensitive epilepsy in Papio papio as a model for drug studies.
Topics: Animals; Anticonvulsants; Benzodiazepines; Carbamazepine; Drug Evaluation, Preclinical; gamma-Aminob | 1978 |
Antagonism of the enhanced susceptibility to audiogenic seizures during alcohol withdrawal in the rat by gamma-aminobutyric acid (GABA) and "GABA-mimetic" agents.
Topics: 4-Aminobutyrate Transaminase; Acoustic Stimulation; Alcoholism; Aminobutyrates; Animals; Binding, Co | 1979 |
On certain relationships between gamma-aminobutyric acid (GABA) and dopaminergic agents in pentylenetetrazol convulsions.
Topics: Amantadine; Animals; Apomorphine; Dextroamphetamine; Ditiocarb; Dopamine; Drug Interactions; gamma-A | 1978 |
Changes in brain levels of cyclic nucleotides and gamma-aminobutyric acid in barbiturate dependence and withdrawal.
Topics: Acoustic Stimulation; Animals; Barbital; Barbiturates; Brain; Cyclic AMP; Cyclic GMP; gamma-Aminobut | 1979 |
Epileptogenic doses of penicillin do not reduce a monosynaptic GABA-mediated postsynaptic inhibition in the intact anesthetized cat.
Topics: Animals; Cats; Cerebellum; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Membrane Poten | 1979 |
Lead, GABA, and seizures: effects of subencephalopathic lead exposure on seizure sensitivity and GABAergic function.
Topics: 4-Aminobutyrate Transaminase; Animals; Animals, Newborn; Blood-Brain Barrier; Convulsants; Female; g | 1979 |
Anticonvulsant activity of muscimol against seizures induced by impairment of GABA-mediated neurotransmission.
Topics: Animals; Anticonvulsants; Bicuculline; gamma-Aminobutyric Acid; Isoniazid; Male; Muscimol; Oxazoles; | 1979 |
GABA synthesis and uptake in penicillin focus.
Topics: Aminobutyrates; Animals; Carboxy-Lyases; Cats; Cerebral Cortex; Electroencephalography; gamma-Aminob | 1975 |
Effects of alterations in the metabolism of gamma-aminobutyrate on convulsant potencies.
Topics: 3-Mercaptopropionic Acid; Aminobutyrates; Aminooxyacetic Acid; Animals; Bicuculline; Diacetyl; Drug | 1977 |
Effect of n-dipropylacetate on amino acid concentrations in mouse brain: correlations with anti-convulsant activity.
Topics: Animals; Aspartic Acid; Brain; Female; gamma-Aminobutyric Acid; Kinetics; Male; Mice; Noise; Seizure | 1978 |
Involvement of central GABA-ergic systems in convulsions and aggressive behavior.
Topics: 4-Aminobutyrate Transaminase; Aggression; Allylglycine; Animals; Bicuculline; Brain; Fatty Acids; ga | 1979 |
Brain gamma-aminobutyric acid and acoustic priming in C57BL/6Bg mice.
Topics: Acoustic Stimulation; Alanine; Aminobutyrates; Aminooxyacetic Acid; Animals; Bicuculline; Brain Chem | 1977 |
Modification of orientation sensitivity of cat visual cortex neurons by removal of GABA-mediated inhibition.
Topics: 3-Mercaptopropionic Acid; Animals; Bicuculline; Cats; Dose-Response Relationship, Drug; Electroencep | 1979 |
Effects of taurine, glycine and GABA on convulsions produced by strychnine in the rabbit.
Topics: Animals; Electroencephalography; gamma-Aminobutyric Acid; Glycine; Male; Rabbits; Seizures; Strychni | 1979 |
On the mechanism of pyridoxal phosphate-related convulsions as implicated in enhanced transport of GABA.
Topics: Animals; Antimetabolites; Cerebral Cortex; gamma-Aminobutyric Acid; Male; Pyridoxal Kinase; Pyridoxa | 1979 |
Gabuculine and isogabaculine: in vivo biochemistry and pharmacology in mice.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Brain; Convulsants; Cyclohexanecarboxylic Ac | 1979 |
The time course of brain and blood catecholamines, catechol O-methyltransferase, and amino acids in rats convulsed by oxygen at high pressure.
Topics: Amino Acids; Ammonia; Animals; Brain; Catechol O-Methyltransferase; Catecholamines; gamma-Aminobutyr | 1979 |
Neurophysiological and neurochemical studies on the action of the anticonvulsant gamma-hydroxy, gamma-ethyl, gamma-phenyl-butyramide.
Topics: Amygdala; Animals; Anticonvulsants; Bicuculline; Brain; Cats; Cerebral Cortex; Drug Synergism; Elect | 1979 |
Stability of synaptosomal GABA levels and their use in determining the in vivo effects of drugs: convulsant agents.
Topics: Acetates; Aminooxyacetic Acid; Animals; Brain; gamma-Aminobutyric Acid; Hydrazines; Isoniazid; Kinet | 1979 |
Influence of inhibitors of the high affinity GABA uptake on seizure thresholds in mice.
Topics: Animals; Atropine; Brain Chemistry; Electroshock; gamma-Aminobutyric Acid; Male; Mice; Muscimol; Nip | 1979 |
gamma-Aminobutyric acid in subcellular fractions of mouse brain and its relation to convulsions.
Topics: Animals; Brain; gamma-Aminobutyric Acid; Isoniazid; Male; Mice; Penicillamine; Seizures; Semicarbazi | 1979 |
Release of exogenous gamma-[3H]aminobutyric acid during seizure activity in chronically denervated and normal cat cortex.
Topics: Animals; Cats; Cerebral Cortex; Decerebrate State; Electric Stimulation; Female; gamma-Aminobutyric | 1979 |
Effects of gamma-acetylenic GABA and gamma-vinyl GABA on metrazol-activated, and kindled seizures.
Topics: Alkynes; Aminocaproates; Animals; Arousal; Drug Interactions; Electric Stimulation; Electroencephalo | 1979 |
Attempts to correlate alterations in brain GABA metabolism by GABA-T inhibitors with their anticonvulsant effects.
Topics: 4-Aminobutyrate Transaminase; Acoustic Stimulation; Animals; Anticonvulsants; Brain; gamma-Aminobuty | 1979 |
Hypersynchronisation and sedation produced by GABA-transaminase inhibitors and picrotoxin: does GABA participate in sleep control?
Topics: 4-Aminobutyrate Transaminase; Animals; Behavior, Animal; Cerebral Cortex; Dose-Response Relationship | 1979 |
Role of dopaminergic and GABA-ergic interactions in seizure susceptibility.
Topics: Aminooxyacetic Acid; Animals; Apomorphine; Dopamine; Electroshock; Female; gamma-Aminobutyric Acid; | 1979 |
Release of gamma-aminobutyric acid from isolated brain synaptosomes during semicarbazide-induced convulsions.
Topics: Aminooxyacetic Acid; Animals; Brain; Calcium; gamma-Aminobutyric Acid; Male; Mice; Potassium; Seizur | 1979 |
Effect of antivitamin B6 on regional GABA metabolism in mouse brain and its relation to convulsions.
Topics: 4-Aminobutyrate Transaminase; Aminooxyacetic Acid; Animals; Brain; gamma-Aminobutyric Acid; Glutamat | 1979 |
[Modifications of the synaptosomal level of gamma-aminobutyric acid during convulsions provoked by pentamethylenetetrazol (author's transl)].
Topics: Animals; Brain; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Male; Pentylenetetrazole; Rats; Se | 1979 |
[Role of uridine and pathogenesis of epileptic seizures].
Topics: Animals; Brain; gamma-Aminobutyric Acid; Glycine; Rats; Seizures; Uracil Nucleotides; Uridine Monoph | 1979 |
Neurochemical aspects of ethanol dependence and withdrawal reactions in mice.
Topics: Alcoholism; Animals; Biogenic Amines; Brain Chemistry; DNA; Ethanol; gamma-Aminobutyric Acid; Humans | 1977 |
Determination of in vivo activity of putative GABA-like compounds [proceedings].
Topics: Animals; Catalepsy; Female; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Mice; Seizures; Tremo | 1979 |
Release of gamma-aminobutyric acid from hippocampal slices of the rat following generalized seizures induced by daily electrical stimulation of entorhinal cortex.
Topics: Aminobutyrates; Animals; Cerebral Cortex; Electric Stimulation; gamma-Aminobutyric Acid; Hippocampus | 1977 |
Running fit induced by injection of semicarbazide into the superior colliculus of the mouse.
Topics: Aminooxyacetic Acid; Animals; Brain; gamma-Aminobutyric Acid; Injections; Male; Mice; Pyridoxine; Ru | 1977 |
Additional studies on the importance of glycine and GABA in mediating the actions of benzodiazepines.
Topics: Aminobutyrates; Animals; Bicuculline; Diazepam; Dose-Response Relationship, Drug; gamma-Aminobutyric | 1977 |
[Biochemistry of epilepsy: the experimental audiogenic model].
Topics: Animals; Choline O-Acetyltransferase; Disease Models, Animal; Ear, Middle; gamma-Aminobutyric Acid; | 1977 |
On some relationships between gamma-aminobutyric acid (GABA) and the cholinergic mechanisms in pentylenetetrazol convulsions.
Topics: Aminobutyrates; Animals; Arecoline; gamma-Aminobutyric Acid; Male; Mice; Parasympathetic Nervous Sys | 1977 |
Naloxone as a GABA antagonist: evidence from iontophoretic, receptor binding and convulsant studies.
Topics: Action Potentials; Aminobutyrates; Animals; Binding, Competitive; Brain; GABA Antagonists; gamma-Ami | 1978 |
Measuring changes in cerebral glutamate and GABA metabolism prior to convulsions induced by 3-mercaptopropionate.
Topics: 3-Mercaptopropionic Acid; Aminobutyrates; Animals; Brain; Female; gamma-Aminobutyric Acid; Glutamate | 1978 |
Effect of L-cycloserine on brain GABA metabolism.
Topics: 4-Aminobutyrate Transaminase; Alanine Transaminase; Aminobutyrates; Animals; Brain; Chickens; Cyclos | 1978 |
The prolonged anticonvulsant action of taurine on genetically determined seizure-susceptibility.
Topics: Acoustic Stimulation; Aminoisobutyric Acids; Animals; Electroshock; gamma-Aminobutyric Acid; Genicul | 1978 |
Regional changes in cerebral GABA concentration and convulsions produced by D and by L-allylglycine.
Topics: Aminobutyrates; Animals; Brain; Female; gamma-Aminobutyric Acid; Glycine; Rats; Seizures; Stereoisom | 1978 |
Influence of taurine dosage on cobalt epilepsy in mice.
Topics: Amino Acids; Animals; Cerebral Cortex; Cobalt; Female; gamma-Aminobutyric Acid; Glutamates; Glutamin | 1978 |
GABA-mediated inhibition in the epileptogenic focus, a process which may be involved in the mechanism of the cobalt-induced epilepsy.
Topics: Animals; Cerebral Cortex; Cobalt; Culture Techniques; Evoked Potentials; gamma-Aminobutyric Acid; Gl | 1978 |
[Effects of imidazole, papaverine and theophylline on the picrotoxin convulsion-seizure threshold. The correlation with gamma-aminobutyric acid (GABA) and diazepam].
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Drug Antagonism; Drug Interactions; gamma-Amino | 1978 |
Gamma aminobutyric acid metabolism in different areas of rat brain at the onset of soman-induced convulsions.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Brain; gamma-Aminobutyric Acid; Glutamate De | 1978 |
Relationship between gamma-aminobutyric acid metabolism and antivitamin B6-induced convulsions.
Topics: 4-Aminobutyrate Transaminase; Acetates; Aminooxyacetic Acid; Animals; Brain; gamma-Aminobutyric Acid | 1978 |
Properties of two derivatives of gamma-aminobutyric acid (GABA) capable of abolishing Cardiazol- and bicuculline-induced convulsions in the rat.
Topics: Animals; Bicuculline; Brain; Chemical Phenomena; Chemistry, Physical; Female; gamma-Aminobutyric Aci | 1978 |
The influence of GABA on discharges of cortical epileptogenic focus.
Topics: Action Potentials; Animals; Cerebral Cortex; gamma-Aminobutyric Acid; Male; Neural Inhibition; Rats; | 1978 |
Glutamate-gamma-aminobutyric acid metabolism in cerebral cortex of rat in leptazol-induced convulsions.
Topics: Animals; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamates; Glutamine; M | 1978 |
Anticonvulsant action of ethanolamine-O-sulphate and di-n-propylacetate and the metabolism of gamma-aminobutyric acid (GABA) in mice with audiogenic seizures.
Topics: 4-Aminobutyrate Transaminase; Acoustic Stimulation; Aldehyde Oxidoreductases; Aminobutyrates; Animal | 1976 |
The modification of the ethanol withdrawal syndrome in rats by di-n-propylacetate.
Topics: Acoustic Stimulation; Alcoholism; Animals; gamma-Aminobutyric Acid; Humans; Male; Motor Activity; Ra | 1976 |
Effects of chronic treatment with amino-oxyacetic acid or sodium n-dipropylacetate on brain GABA levels and the development and regression of cobalt epileptic foci in rats.
Topics: 4-Aminobutyrate Transaminase; Acetates; Aminobutyrates; Aminooxyacetic Acid; Animals; Brain; Brain C | 1976 |
Effects of edetate on seizure suppressing actions of taurine and GABA.
Topics: Aminobutyrates; Animals; Anticonvulsants; Calcium; Dose-Response Relationship, Drug; Edetic Acid; ga | 1975 |
[Suppression of seizures by taurine - effects of edetate on actions of taurine and GABA (author's transl)].
Topics: Aminobutyrates; Animals; Anticonvulsants; Edetic Acid; GABA Antagonists; gamma-Aminobutyric Acid; Ma | 1975 |
Longitudinal changes of brain amino acid content occurring before, during and after epileptic activity.
Topics: Amino Acids; Animals; Cats; Cerebral Cortex; Cobalt; gamma-Aminobutyric Acid; Penicillin G; Seizures | 1977 |
Antiseizure activity of gamma-acetylenic gamma-aminobutyric acid: a catalytic irreversible inhibitor of gamma-aminobutyric acid transaminase.
Topics: 4-Aminobutyrate Transaminase; Aminobutyrates; Animals; Anticonvulsants; Brain Chemistry; Electroshoc | 1977 |
Convulsions induced by hyperbaric oxygen: inhibition by phenobarbital, diazepam and baclofen.
Topics: Aminobutyrates; Animals; Baclofen; Diazepam; Female; gamma-Aminobutyric Acid; Glycine; Hyperbaric Ox | 1977 |
gamma-Aminobutyric acid metabolism in subcellular particles of mouse brain and its relationship to convulsions.
Topics: 4-Aminobutyrate Transaminase; Aminobutyrates; Animals; Brain; gamma-Aminobutyric Acid; Glutamate Dec | 1977 |
Effects of the Areca nut constituents arecaidine and guvacine on the action of GABA in the cat central nervous system.
Topics: Action Potentials; Alanine; Aminobutyrates; Animals; Areca; Arecoline; Bicuculline; Cats; Cerebellum | 1977 |
Audiogenic seizure protection by elevated brain GABA concentration in mice: effects of gamma-acetylenic gaba and gamma-vinyl GABA, two irreversible GABA-T inhibitors.
Topics: 4-Aminobutyrate Transaminase; Acoustic Stimulation; Aminobutyrates; Animals; Brain Chemistry; gamma- | 1977 |
Pharmacogenetic differences in audiogenic seizure priming of C57BL/6Bg and DBA/1Bg-asr mice.
Topics: Acoustic Stimulation; Aminooxyacetic Acid; Animals; Brain Chemistry; Cycloheximide; Female; gamma-Am | 1977 |
Bicyclic phosphorus esters that are potent convulsants and GABA antagonists.
Topics: Action Potentials; Aminobutyrates; Bridged Bicyclo Compounds; Bridged-Ring Compounds; GABA Antagonis | 1976 |
Rat brain GABA and glutamate content in m-fluorotyrosine convulsions.
Topics: Aminobutyrates; Animals; Brain Chemistry; Depression, Chemical; Female; gamma-Aminobutyric Acid; Glu | 1976 |
Elevation of central gamma-aminobutyric acid levels by isoniazid in mice and convulsant thresholds.
Topics: Aminobutyrates; Animals; Brain; Brain Chemistry; Electroshock; gamma-Aminobutyric Acid; Glutamate De | 1976 |
3-Isoxazolidone--an inhibitor of GABA metabolism.
Topics: Aminobutyrates; Animals; Brain; Chickens; Depression, Chemical; GABA Antagonists; gamma-Aminobutyric | 1976 |
Retention disruption following post-trial picrotoxin injection into the substantia nigra.
Topics: Animals; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Male; Memory; Picrotoxin; Rats; | 1976 |
Levels of norepinephrine in rat cerebellum after administration of the convulsant 3-mercaptopropionic acid.
Topics: Animals; Cerebellum; Convulsants; gamma-Aminobutyric Acid; Norepinephrine; Propionates; Rats; Seizur | 1976 |
Modification of pp' DDT induced convulsions by changes in the level of cerebral gamma-aminobutyric acid in mice.
Topics: Aminobutyrates; Aminooxyacetic Acid; Ammonia; Animals; Brain; DDT; gamma-Aminobutyric Acid; Hydroxyl | 1976 |
A dual mechanism for the anticonvulsant action of aminooxyacetic acid.
Topics: Acetates; Allyl Compounds; Aminooxyacetic Acid; Animals; Anticonvulsants; Behavior, Animal; Brain Ch | 1976 |
Antivitamin B6 induced ultrastructural changes in the hippocampus of the convulsant rabbit and its biochemical correlates.
Topics: Animals; Caudate Nucleus; Female; gamma-Aminobutyric Acid; Hippocampus; Hypothalamus; Male; Putamen; | 1976 |
A correlation between changes in gamma-aminobutyric acid metabolism and seizures induced by antivitamin B6.
Topics: 4-Aminobutyrate Transaminase; Aminobutyrates; Animals; Brain; gamma-Aminobutyric Acid; Glutamate Dec | 1976 |
Effect of succinic semialdehyde on seizure caused by vitamin B6 antagonists.
Topics: Aldehydes; Animals; gamma-Aminobutyric Acid; Hydroxybutyrates; Male; Mice; Penicillamine; Pyridoxine | 1976 |
Regional differences in GABA uptake.
Topics: Aminobutyrates; Animals; Brain; Cerebral Cortex; gamma-Aminobutyric Acid; Rats; Seizures; Synaptosom | 1976 |
Effect of drug-induced increase of brain GABA levels on penicillin focus.
Topics: Acetates; Action Potentials; Aminobutyrates; Aminooxyacetic Acid; Animals; Brain Chemistry; Cats; Ce | 1975 |
[The mechanism of the anticonvulsive action of diazepam].
Topics: Aminobutyrates; Animals; Anticonvulsants; Brain; Brain Chemistry; Chromatography, Paper; Diazepam; E | 1975 |
Enhancement of picrotoxin convulsions in chicks and mice by the prior intraperitoneal injection of hypertonic GABA or mannitol.
Topics: Aminobutyrates; Animals; Animals, Newborn; Chickens; Drug Synergism; gamma-Aminobutyric Acid; Hypert | 1975 |
Evidence for a role of glutamate decarboxylase activity as a regulatory mechanism of cerebral excitability.
Topics: Aminobutyrates; Animals; Azides; Brain; Carboxy-Lyases; gamma-Aminobutyric Acid; Glutamate Decarboxy | 1975 |
The psychopharmacology of audiogenic seizure.
Topics: Acoustic Stimulation; Animals; Diet; gamma-Aminobutyric Acid; Mice; Norepinephrine; Seizures; Seroto | 1975 |
The anticonvulsant action of GABA-elevating agents: a re-evaluation.
Topics: Allyl Compounds; Aminobutyrates; Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; Drug Evaluati | 1975 |
Locomotor activity and seizures induced by picrotoxin in the fastigeal nucleus of the rat.
Topics: Animals; Cerebellar Nuclei; gamma-Aminobutyric Acid; Locomotion; Male; Neural Inhibition; Ouabain; P | 1975 |
[Antagonistic effect of sodium hydroxybutyrate on several effects of aminoxyacetic acid].
Topics: Acetates; Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; gamma-Aminobutyric Acid; Hydroxybuty | 1975 |
Studies on the neuropharmacological activity of bicuculline and related compounds.
Topics: Acetylcholinesterase; Acetylthiocholine; Aminobutyrates; Animals; Astacoidea; Bicuculline; Brain; El | 1976 |
Differential decrease of GABA in the substantia nigra and other discrete regions of the rabbit brain during the preictal period of methoxypyridoxine-induced seizures.
Topics: Action Potentials; Aminobutyrates; Animals; Brain; Caudate Nucleus; Cerebellar Cortex; Frontal Lobe; | 1976 |
Anticonvulsant activity of aminooxyacetic acid on convulsions induced by thiosemicarbazide.
Topics: Acetates; Aminobutyrates; Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; gamma-Aminobutyric A | 1976 |
Effects of antiepileptic drugs, calcium channel blockers and other compounds on seizures induced by activation of voltage-dependent L calcium channel in DBA/2 mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1992 |
[The effect of acupuncture on high oxygen pressure-induced convulsion and its relationship to the brain GABA concentration in mice].
Topics: Acupuncture Therapy; Animals; Brain; Female; gamma-Aminobutyric Acid; Hyperbaric Oxygenation; Male; | 1992 |
Morphological evidence for altered synaptic organization and structure in the hippocampal formation of seizure-sensitive gerbils.
Topics: Animals; Axons; gamma-Aminobutyric Acid; Gerbillinae; Glutamate Decarboxylase; Hippocampus; Immunohi | 1992 |
Selective changes in GABAergic transmission in substantia nigra and superior colliculus caused by ethanol and ethanol withdrawal.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Animals; Autoradiography; Brain Mapping; Culture Techniques | 1992 |
Yohimbine-induced seizures involve NMDA and GABAergic transmission.
Topics: Animals; Bicuculline; Carbolines; Convulsants; Dioxanes; gamma-Aminobutyric Acid; Idazoxan; Male; Mi | 1992 |
Age-dependent changes in substantia nigra GABA-mediated seizure suppression.
Topics: Aging; Animals; Animals, Newborn; Baclofen; Bicuculline; Dominance, Cerebral; Energy Metabolism; Flu | 1992 |
Neuroethological evaluation of audiogenic seizures and audiogenic-like seizures induced by microinjection of bicuculline into the inferior colliculus. II. Effects of nigral clobazam microinjections.
Topics: Acoustic Stimulation; Animals; Anti-Anxiety Agents; Anticonvulsants; Arousal; Behavior, Animal; Benz | 1992 |
Neuroethological evaluation of audiogenic seizures and audiogenic-like seizures induced by microinjection of bicuculline into the inferior colliculus. I. Effects of midcollicular knife cuts.
Topics: Acoustic Stimulation; Animals; Arousal; Behavior, Animal; Bicuculline; Brain Mapping; Cerebral Corte | 1992 |
Quantitative autoradiographic measurements of functional changes induced by generalized seizures in the developing rat brain: central adenosine and benzodiazepine receptors and local cerebral glucose utilization.
Topics: Age Factors; Animals; Autoradiography; Bicuculline; Blood Glucose; Brain; Brain Mapping; Epilepsy, G | 1992 |
Vigabatrin for startle-disease with altered cerebrospinal-fluid free gamma-aminobutyric acid.
Topics: 4-Aminobutyrate Transaminase; Adolescent; Aminocaproates; Anticonvulsants; Enzyme Inhibitors; Female | 1992 |
Hypoxia increases extracellular concentrations of excitatory and inhibitory neurotransmitters in subsequently induced seizure: in vivo microdialysis study in the rabbit.
Topics: Animals; Aspartic Acid; Bicuculline; Brain; Dialysis; Electroencephalography; gamma-Aminobutyric Aci | 1992 |
Pharmacological, toxicological and neurochemical effects of delta 2(E)-valproate in animals.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Brain; Fatty Acids, Monounsaturated; gamma-Aminobutyr | 1992 |
Kindling increases brain levels of NAAG and seizures reduce activity of a NAAG-hydrolyzing enzyme, NAALADase.
Topics: Amygdala; Animals; Aspartic Acid; Brain; Brain Mapping; Dipeptidases; Dipeptides; Disease Models, An | 1992 |
Effects of benzodiazepine receptor ligands with different intrinsic activities on seizures induced by inhibition of GAD.
Topics: Animals; Anti-Anxiety Agents; Carbolines; Diazepam; Flumazenil; gamma-Aminobutyric Acid; Glutamate D | 1992 |
Ethacrynic acid-induced convulsions and brain neurotransmitters in mice.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Animals; Brain; Chloride Channels; Ethacrynic Acid; gamm | 1992 |
Synaptic connections of seizure-sensitive neurons in the dentate gyrus.
Topics: Animals; Brain Mapping; Calcium-Binding Proteins; Chlorocebus aethiops; Cholecystokinin; Cytoplasmic | 1992 |
Limbic seizure-induced changes in extracellular amino acid levels in the hippocampal formation: a microdialysis study of freely moving rats.
Topics: Amino Acids; Amygdala; Animals; Aspartic Acid; Brain Mapping; Chromatography, High Pressure Liquid; | 1992 |
Modulation of GABAergic transmission by ethanol.
Topics: Animals; Anticonvulsants; Azides; Benzodiazepines; Brain Chemistry; Ethanol; Female; Flumazenil; GAB | 1992 |
The gamma-aminobutyric acid (GABA) uptake inhibitor, tiagabine, increases extracellular brain levels of GABA in awake rats.
Topics: Analysis of Variance; Animals; Brain; Chromatography, High Pressure Liquid; gamma-Aminobutyric Acid; | 1992 |
[Effects of drugs on the convulsions induced by the combination of a new quinolone antimicrobial, enoxacin, and a nonsteroidal anti-inflammatory drug, fenbufen, in mice].
Topics: Amino Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Diazepam; Dizocilpin | 1992 |
Disturbance of GABA metabolism in pyridoxine-dependent seizures.
Topics: Brain; Chromosomes, Human, Pair 2; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Humans; Infant; | 1992 |
Neuropharmacology of amide derivatives of P-GABA.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bicuculline; Brain; gamma-Aminobutyric Acid; Hyp | 1992 |
NNC-711, a novel potent and selective gamma-aminobutyric acid uptake inhibitor: pharmacological characterization.
Topics: Animals; Anticonvulsants; Astrocytes; Behavior, Animal; Brain; Carbolines; Cells, Cultured; Convulsa | 1992 |
Age dependency of the susceptibility of rats to aminooxyacetic acid seizures.
Topics: Aging; Aminooxyacetic Acid; Animals; Anticonvulsants; Body Temperature; Brain; Carbamazepine; Clonaz | 1992 |
Susceptibility to seizures produced by chemical convulsants and maximal electric shock in rats after electrolytic lesions into the red nucleus.
Topics: Acetylcholine; Animals; Brain Chemistry; Carbachol; Convulsants; Electroencephalography; Electroshoc | 1992 |
Anticonvulsant role of nigrotectal projection in the maximal electroshock model of epilepsy--I. Mapping of dorsal midbrain with bicuculline.
Topics: Animals; Bicuculline; Brain Mapping; Electroshock; Female; gamma-Aminobutyric Acid; Male; Mesencepha | 1992 |
Effects of cholecystokinin octapeptide on genetically determined seizure susceptibility.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Disease Susceptibility; gamma-Aminobutyric Acid; Injectio | 1992 |
Apparent disappearance of postseizure inhibitions and intensity of seizures during the development of rapid kindling in rabbits.
Topics: Animals; Electric Stimulation; Electrodes, Implanted; Electroencephalography; gamma-Aminobutyric Aci | 1992 |
Transient reduction of cerebral blood flow leads to longlasting increase in GABA content in vulnerable structures and decreased susceptibility to bicuculline induced seizures.
Topics: Animals; Bicuculline; Brain Chemistry; Carotid Arteries; Cerebrovascular Circulation; gamma-Aminobut | 1992 |
Involvement of GABAergic mechanisms in chloroquine-induced seizures in mice.
Topics: Aminobutyrates; Aminooxyacetic Acid; Animals; Baclofen; Chloroquine; Diazepam; gamma-Aminobutyric Ac | 1992 |
MK-801 prevents chemical kindling induced by pentylenetetrazol in rats.
Topics: Amino Acids; Animals; Dizocilpine Maleate; Drug Administration Schedule; gamma-Aminobutyric Acid; In | 1991 |
Lack of proconvulsant action of GABA depletion in substantia nigra in several seizure models.
Topics: Animals; Bicuculline; Cerebral Cortex; gamma-Aminobutyric Acid; Isoniazid; Kainic Acid; Male; Microi | 1991 |
Autoradiographic changes in central benzodiazepine binding sites and their coupling to gamma-aminobutyric acid receptors after seizures in the developing rat.
Topics: Age Factors; Animals; Animals, Newborn; Autoradiography; Brain; Female; Flunitrazepam; gamma-Aminobu | 1991 |
In vivo bidirectional modulatory effect of benzodiazepine receptor ligands on GABAergic transmission evaluated by positron emission tomography in non-human primates.
Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Binding, Competitive; Carbolines; Cerebral Cort | 1991 |
GABA/BZ-and NMDA-receptor interaction in digoxin-induced convulsions in rats.
Topics: Animals; Baclofen; Diazepam; Digoxin; Dizocilpine Maleate; Female; gamma-Aminobutyric Acid; Injectio | 1991 |
An investigation of the involvement of GABA in certain pharmacological effects of delta-9-tetrahydrocannabinol.
Topics: Amino Acids; Amino Acids, Neutral; Analgesics; Animals; Anticonvulsants; Body Temperature; Cannabidi | 1991 |
Abnormal endogenous amino acid release in brain slices from vitamin B-6 restricted neonatal rats.
Topics: Amino Acids; Animals; Animals, Newborn; Brain Chemistry; Chromatography, High Pressure Liquid; Elect | 1991 |
2-Phenyl-3H-imidazo[4,5-b]pyridine-3-acetamides as non-benzodiazepine anticonvulsants and anxiolytics.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Benzodiazepines; Binding, Competitive; Cereb | 1991 |
The effect of medetomidine on GABA and benzodiazepine receptors in vivo: lack of anxiolytic but some evidence of possible stress-protective activity.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Bicuculline; Brain; Cerebral Cortex; Flumazenil; Flu | 1991 |
Paradoxical role of GABA in a chronic model of petit mal (absence)-like epilepsy in the rat.
Topics: Animals; Anticonvulsants; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; | 1990 |
Pharmacological evidence indicating a role of GABAergic systems in termination of limbic seizures.
Topics: Animals; Baclofen; Bicuculline; Chloride Channels; GABA-A Receptor Antagonists; gamma-Aminobutyric A | 1990 |
Convulsions and wet-dog shakes produced by systemic or intrahippocampal administration of ruthenium red in the rat.
Topics: Animals; Behavior, Animal; gamma-Aminobutyric Acid; Hippocampus; Injections; Injections, Intraperito | 1991 |
Evidence that genetic differences in habituation and GABAergic mechanisms may be related to sensitivity to ethanol and development of ethanol tolerance in mice.
Topics: Animals; Avoidance Learning; Bicuculline; Body Temperature; Brain; Drug Tolerance; Environment; Etha | 1991 |
Alterations of GABA metabolism and seizure susceptibility in the substantia nigra of the kindled rat acclimating to changes in osmotic state.
Topics: 4-Aminobutyrate Transaminase; Animals; Blood; Electric Stimulation; gamma-Aminobutyric Acid; Kindlin | 1991 |
(4S)-4-amino-5,6-heptadienoic acid (MDL 72483): a potent anticonvulsant GABA-T inhibitor.
Topics: 3-Mercaptopropionic Acid; 4-Aminobutyrate Transaminase; Aminocaproates; Animals; Anticonvulsants; Fa | 1991 |
[Drug-induced seizures in taurine-deficient mice].
Topics: Amino Acids; Animals; Brain Chemistry; Female; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred ICR | 1991 |
Formation of GABOB from 2-hydroxyputrescine and its anticonvulsant effect.
Topics: 4-Aminobutyrate Transaminase; Amine Oxidase (Copper-Containing); Amino Acids; Animals; Anticonvulsan | 1991 |
Neuropharmacological studies on the venom of Vipera russelli.
Topics: Aggression; Animals; Behavior, Animal; Body Temperature; Brain; Chlorpromazine; Dose-Response Relati | 1991 |
Characterization of tiagabine (NO-328), a new potent and selective GABA uptake inhibitor.
Topics: Animals; Anticonvulsants; Carbolines; Clonazepam; Convulsants; Diazepam; Female; GABA Antagonists; g | 1991 |
Decreased susceptibility to seizures induced by bicuculline after transient bilateral clamping of the carotid arteries in rats.
Topics: Animals; Bicuculline; Brain Chemistry; Carotid Arteries; Constriction; Disease Susceptibility; Femal | 1991 |
Domoic acid induced seizure activity in rats.
Topics: Action Potentials; Animals; Brain; Electroencephalography; gamma-Aminobutyric Acid; Glutamate Decarb | 1991 |
Some correlations between local anesthetic-induced convulsions and gamma-aminobutyric acid in rat spinal cord.
Topics: Aminooxyacetic Acid; Anesthetics, Local; Animals; Dose-Response Relationship, Drug; gamma-Aminobutyr | 1991 |
Gabapentin increases aminooxyacetic acid-induced GABA accumulation in several regions of rat brain.
Topics: Acetates; Amines; Aminooxyacetic Acid; Animals; Anticonvulsants; Brain Chemistry; Cyclohexanecarboxy | 1991 |
Action of thiopental in isoniazid-induced seizures: GABA augmentation or electroencephalographic suppression?
Topics: Electroencephalography; gamma-Aminobutyric Acid; Humans; Isoniazid; Seizures; Thiopental | 1991 |
Low magnesium epileptogenesis in the rat hippocampal slice: electrophysiological and pharmacological features.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; gamma-Aminobutyric Acid; Hippocampus; In Vitro Te | 1990 |
Amino acid neurotransmitter alterations in three sublines of Rb mice differing by their susceptibility to audiogenic seizures.
Topics: Acoustic Stimulation; Amino Acids; Animals; Aspartic Acid; Brain; gamma-Aminobutyric Acid; Glutamate | 1990 |
Transmitter release in hippocampal slices from rats with limbic seizures produced by systemic administration of kainic acid.
Topics: Animals; Dopamine; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippocampus; Kainic Acid; Kin | 1990 |
Effects of anticonvulsants on the electroconvulsive threshold lowered by DA, 5-HT or GABA depletion.
Topics: Animals; Anticonvulsants; Disease Susceptibility; Dopamine; Electroshock; gamma-Aminobutyric Acid; M | 1990 |
Central nervous system toxicity of quinolones: human and animal findings.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Central Nervous System; Cip | 1990 |
Involvement of the nigral output pathways in the inhibitory control of the substantia nigra over generalized non-convulsive seizures in the rat.
Topics: Animals; Brain; Dopamine; Electroencephalography; GABA Antagonists; gamma-Aminobutyric Acid; Hydroxy | 1990 |
GAD-immunoreactive neurons are preserved in the hippocampus of rats with spontaneous recurrent seizures.
Topics: Animals; Epilepsies, Partial; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hippocampus; Male; N | 1990 |
NMDA receptor activation mediates the loss of GABAergic inhibition induced by recurrent seizures.
Topics: Animals; Dibenzocycloheptenes; Dizocilpine Maleate; gamma-Aminobutyric Acid; Hippocampus; Ketamine; | 1990 |
Species dependent dual modulation of the benzodiazepine/GABA receptor chloride channel by dihydroergosine.
Topics: Animals; Bicuculline; Brain; Chloride Channels; Diazepam; Ergotamines; Female; gamma-Aminobutyric Ac | 1990 |
Hyperthermia-induced seizures with a servo system: neurophysiological roles of age, temperature elevation rate and regional GABA content in the rat.
Topics: Aging; Animals; Body Temperature; Brain Chemistry; Female; gamma-Aminobutyric Acid; Hyperthermia, In | 1990 |
Are GABAB receptors involved in the pharmacological effects of ethanol?
Topics: Animals; Baclofen; Cells, Cultured; Chlorine; Diazepam; Ethanol; gamma-Aminobutyric Acid; Male; Mice | 1990 |
Distribution of GABA concentrations and GAD activities in the parietal cortex and the hippocampal CA1 in an El mouse.
Topics: Animals; Brain Mapping; gamma-Aminobutyric Acid; Glutamate Dehydrogenase; Hippocampus; Mice; Mice, N | 1990 |
GABA-gated chloride ion influx in brains of epileptic El mice.
Topics: Animals; Brain; Chlorides; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Ion Channel Ga | 1990 |
Protection against cyanide-induced convulsions with alpha-ketoglutarate.
Topics: Animals; Brain; Brain Chemistry; Calcium; Cyanides; gamma-Aminobutyric Acid; Ketoglutaric Acids; Mal | 1990 |
Plus-maze behavior and susceptibility to 3-mercaptopropionate-induced seizures in rat lines selected for high and low alcohol sensitivity.
Topics: 3-Mercaptopropionic Acid; Animals; Behavior, Animal; Drug Tolerance; Ethanol; gamma-Aminobutyric Aci | 1990 |
Long-term changes in sensitivity to GABA in dorsal raphe neurons following amygdala kindling.
Topics: Action Potentials; Amygdala; Animals; Bicuculline; Convulsants; gamma-Aminobutyric Acid; Kindling, N | 1990 |
Suppression of spontaneous generalized non-convulsive seizures in the rat by microinjection of GABA antagonists into the superior colliculus.
Topics: Animals; Bicuculline; GABA Antagonists; gamma-Aminobutyric Acid; Male; Microinjections; Picrotoxin; | 1990 |
CSF gamma-aminobutyric acid in alcoholics and control subjects.
Topics: Adult; Age Factors; Alcohol Drinking; Alcoholism; Chromatography, Ion Exchange; Ethanol; Female; gam | 1990 |
[Acetylcholinesterase activity in blood plasma and various regions of the central nervous system of rats poisoned with lindane. Effect of sodium pentobarbital].
Topics: Acetylcholinesterase; Animals; Anticonvulsants; Brain; gamma-Aminobutyric Acid; Hexachlorocyclohexan | 1985 |
Anticonvulsant drug mechanisms of action.
Topics: Action Potentials; Animals; Anticonvulsants; Barbiturates; Benzodiazepines; Carbamazepine; Clonazepa | 1985 |
Convulsant effect of lindane and regional brain concentration of GABA and dopamine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain Chemistry; Dopamine; gamma-Aminobutyric Acid; Hexachl | 1988 |
Spontaneous EEG spikes in the normal hippocampus. V. Effects of ether, urethane, pentobarbital, atropine, diazepam and bicuculline.
Topics: Anesthetics; Animals; Atropine; Behavior, Animal; Bicuculline; Diazepam; Electroencephalography; Eth | 1988 |
Antidepressants and seizure-interactions at the GABA-receptor chloride-ionophore complex.
Topics: Amitriptyline; Animals; Antidepressive Agents; Cerebral Cortex; Chlorides; Desipramine; gamma-Aminob | 1988 |
Regional concentrations of GABA, serotonin and noradrenaline in brain at onset of seizures induced by lindane (gamma-hexachlorocyclohexane).
Topics: Animals; Brain Chemistry; Chromatography, Gas; Chromatography, High Pressure Liquid; gamma-Aminobuty | 1988 |
Increased sensitivity to inverse agonists and decreased GABA-stimulated chloride influx induced by chronic treatment with FG 7142.
Topics: Animals; Anti-Anxiety Agents; Appetite Depressants; Benzodiazepines; Carbolines; Chlorides; gamma-Am | 1988 |
GABA and seizure initiation in vivo.
Topics: Animals; gamma-Aminobutyric Acid; Kindling, Neurologic; Seizures | 1989 |
GABAergic modulation of lindane (gamma-hexachlorocyclohexane)-induced seizures.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; GABA Antagonists; gamma-Aminobutyric Acid; Hex | 1989 |
Relationship of agonist efficacy to changes in GABA sensitivity and anticonvulsant tolerance following chronic benzodiazepine ligand exposure.
Topics: Animals; Anticonvulsants; Behavior, Animal; Benzodiazepines; Benzodiazepinones; Bicuculline; Brain C | 1989 |
Anticonvulsant activity of the glial GABA uptake inhibitor, THAO, in chemical seizures.
Topics: Animals; Anticonvulsants; gamma-Aminobutyric Acid; Isoniazid; Isoxazoles; Male; Nervous System; Neur | 1989 |
Anticonvulsant action of GABA receptor blockade in the nigrotectal target region.
Topics: Animals; Anticonvulsants; Bicuculline; gamma-Aminobutyric Acid; Male; Rats; Rats, Inbred Strains; Re | 1989 |
Changes in cholinergic but not in GABAergic markers in amygdala, piriform cortex, and nucleus basalis of the rat brain following systemic administration of kainic acid.
Topics: Amygdala; Animals; Basal Ganglia; Behavior, Animal; Biomarkers; Cerebral Cortex; gamma-Aminobutyric | 1989 |
A potent antagonist of the strychnine insensitive glycine receptor has anticonvulsant properties.
Topics: Animals; Anticonvulsants; Aspartic Acid; Cerebral Cortex; Cortical Spreading Depression; Female; gam | 1989 |
Regional changes in the concentrations of glutamate, glycine, taurine, and GABA in the vitamin B-6 deficient developing rat brain: association with neonatal seizures.
Topics: Amino Acids; Animals; Animals, Newborn; Brain; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic | 1989 |
The effect of monoamine depletors on metrazol induced convulsions and brain gamma-aminobutyric acid (GABA) contents in rats.
Topics: Animals; Anticonvulsants; Biogenic Monoamines; Brain; Female; gamma-Aminobutyric Acid; Male; Pentyle | 1989 |
A simple intravenous infusion method in rodents for determining the potency of anticonvulsants acting through GABAergic mechanisms.
Topics: Animals; Anticonvulsants; Convulsants; gamma-Aminobutyric Acid; Infusions, Intravenous; Injections, | 1989 |
Changes in the activity of glutamate related enzymes in cerebral cortex, during insulin-induced seizures.
Topics: Alanine Transaminase; Amino Acids; Animals; Aspartate Aminotransferases; Blood Glucose; Cerebral Cor | 1989 |
Synthesis and anticonvulsant activity of N-phthaloyl GABA--a new GABA derivative.
Topics: Animals; Anticonvulsants; gamma-Aminobutyric Acid; Locomotion; Male; Mice; Muscle Relaxation; Rabbit | 1989 |
The role of the nigrotegmental GABAergic pathway in the propagation of pentylenetetrazol-induced seizures.
Topics: Animals; Bicuculline; gamma-Aminobutyric Acid; Male; Muscimol; Pentylenetetrazole; Pons; Rats; Rats, | 1989 |
Metabolism of 3-(p-chlorophenyl)pyrrolidine. Structural effects in conversion of a prototype gamma-aminobutyric acid prodrug to lactam and gamma-aminobutyric acid type metabolites.
Topics: Amino Acids; Animals; Baclofen; Brain; Chemical Phenomena; Chemistry; Chromatography, High Pressure | 1989 |
[Suppressive effect of GABA-containing liposomes on kindled convulsion].
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Brain; Depression, Chemical; Drug Carriers; gamma-Ami | 1989 |
Injection of benzodiazepines but not GABA or muscimol into pars reticulata substantia nigra suppresses pentylenetetrazol seizures.
Topics: Animals; Benzodiazepines; Flurazepam; gamma-Aminobutyric Acid; Male; Midazolam; Muscimol; Pentylenet | 1989 |
Long lasting effect of a single audiogenic seizure on GABA turnover rates and steady-state levels.
Topics: Acoustic Stimulation; Animals; Brain; gamma-Aminobutyric Acid; Male; Mice; Seizures | 1989 |
Cerebrospinal fluid GABA and seizure control with vigabatrin.
Topics: Adolescent; Adult; Aminocaproates; Anticonvulsants; Carnosine; Female; gamma-Aminobutyric Acid; Huma | 1989 |
Behavioral aspects of GABAergic-dopaminergic interactions in the central nervous system.
Topics: 3-Mercaptopropionic Acid; Animals; Dopamine; gamma-Aminobutyric Acid; Haloperidol; Male; Picrotoxin; | 1989 |
Enhanced sensitivity to beta-carboline inverse agonists in rats chronically treated with FG 7142.
Topics: Animals; Brain; Carbolines; Convulsants; Drug Tolerance; gamma-Aminobutyric Acid; Male; Rats; Rats, | 1987 |
Changes in benzodiazepine/GABA receptor complex function in benzodiazepine-tolerant mice.
Topics: Animals; Anticonvulsants; Bicuculline; Body Temperature; Drug Tolerance; Flurazepam; gamma-Aminobuty | 1988 |
Delta-guanidinovaleric acid as an endogenous and specific GABA-receptor antagonist: electroencephalographic study.
Topics: Animals; Arginine; Cerebral Cortex; Diazepam; Electroencephalography; gamma-Aminobutyric Acid; Male; | 1987 |
The putative endogenous convulsant 3-hydroxykynurenine decreases benzodiazepine receptor binding affinity: implications to seizures associated with neonatal vitamin B-6 deficiency.
Topics: Animals; Brain; Convulsants; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Kynurenine; Male; Rat | 1988 |
Isonicotinic hydrazide causes seizures in scrapie-infected hamsters with shorter latency than in control animals: a possible GABAergic defect.
Topics: Animals; Brain; Brain Chemistry; Cricetinae; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic A | 1985 |
Effects of two convulsant beta-carboline derivatives, DMCM and beta-CCM, on regional neurotransmitter amino acid levels and on in vitro D-[3H]aspartate release in rodents.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Brain Chemistry; Carbolines; Cereb | 1985 |
The interaction of taurine and glutamate metabolism in brains of genetically seizure susceptible and seizure resistant rats.
Topics: Animals; Brain; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Rats; Rats, Inbred Strains; Seiz | 1985 |
Changes in amino-acid neurotransmitters and cAMP in cerebral-spinal fluid from children and rabbits with epilepsy and convulsions.
Topics: Amino Acids; Animals; Child; Cyclic AMP; Epilepsy; gamma-Aminobutyric Acid; Humans; Neurotransmitter | 1985 |
Bidirectional modulation of GABA function by beta-carbolines.
Topics: Acoustic Stimulation; Anesthesia, General; Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning | 1986 |
Effects of carbamazepine and valproic acid on brain immunoreactive somatostatin and gamma-aminobutyric acid in amygdaloid-kindled rats.
Topics: Amygdala; Animals; Brain Chemistry; Carbamazepine; gamma-Aminobutyric Acid; Kindling, Neurologic; Ma | 1986 |
[Central convulsive action of l-securinine].
Topics: Alkaloids; Animals; Azepines; Central Nervous System Stimulants; Diazepam; Drug Synergism; gamma-Ami | 1986 |
The role of GABA and excitatory amino acids in the development of the leptazol-induced epileptogenic EEG.
Topics: Allylglycine; Amino Acids; Animals; Bicuculline; Cerebral Cortex; Clonazepam; Dose-Response Relation | 1986 |
On the role of seizure activity and endogenous excitatory amino acids in mediating seizure-associated hippocampal damage.
Topics: Acetylcholine; Action Potentials; Amino Acids; Animals; Aspartic Acid; Cell Survival; Dendrites; Epi | 1986 |
Amino acid influences on seizures elicited within the inferior colliculus.
Topics: Amino Acids; Aminobutyrates; Animals; Aspartic Acid; gamma-Aminobutyric Acid; Glutamates; Glutamic A | 1987 |
Anti-convulsant effects by reduced glutathione and related aminoacids in rats treated with isoniazid.
Topics: Animals; Brain Chemistry; Cysteine; Drug Interactions; gamma-Aminobutyric Acid; Glutamates; Glutamic | 1988 |
Opioid mechanisms involved in the slow potential change and neuronal refractoriness during cortical spreading depression.
Topics: Animals; Bicuculline; Cerebral Cortex; Cortical Spreading Depression; Electroencephalography; Electr | 1987 |
Evidence that repetitive seizures in the hippocampus cause a lasting reduction of GABAergic inhibition.
Topics: Animals; Electric Stimulation; Electrophysiology; gamma-Aminobutyric Acid; Hippocampus; Male; Neural | 1989 |
Kindling induced changes in parvalbumin immunoreactivity in rat hippocampus and its relation to long-term decrease in GABA-immunoreactivity.
Topics: Animals; gamma-Aminobutyric Acid; Hippocampus; Immunohistochemistry; Kindling, Neurologic; Male; Mus | 1989 |
Decrease in GABA immunoreactivity and alteration of GABA metabolism after kindling in the rat hippocampus.
Topics: Aminooxyacetic Acid; Animals; gamma-Aminobutyric Acid; Hippocampus; Kindling, Neurologic; Male; Rats | 1989 |
Effects of unilateral microinjections of GABAergic drugs into the inferior colliculus on auditory evoked potentials and on audiogenic seizure susceptibility.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Bicuculline; Evoked Potentials, Auditory; Functional | 1989 |
Amplification by glycine of the anticonvulsant effect of THPO, a GABA uptake inhibitor.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Brain Chemistry; Drug Synergism; gamma-Aminobuty | 1985 |
Antagonism of seizures induced by the administration of the endogenous convulsant quinolinic acid into rat brain ventricles.
Topics: Animals; Anticonvulsants; Diazepam; gamma-Aminobutyric Acid; Glycine; Injections, Intraventricular; | 1986 |
Involvement of a GABAergic mechanism in the anticonvulsant effect of pentobarbital against maximal electroshock-induced seizures in rats.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Bicuculline; Drug Interactions; Electroshock; Ethanol; | 1985 |
Suppression by progabide of ethanol withdrawal syndrome in rats.
Topics: Acoustic Stimulation; Animals; Ethanol; gamma-Aminobutyric Acid; Humans; Male; Rats; Rats, Inbred St | 1985 |
Suppression of amygdala-kindled seizure in cats by enhanced GABAergic transmission in the substantia innominata.
Topics: Amygdala; Animals; Basal Ganglia; Cats; Cyclohexanecarboxylic Acids; gamma-Aminobutyric Acid; Inject | 1985 |
Evaluation of different GABA receptor agonists in the kindled amygdala seizure model in rats.
Topics: Amygdala; Animals; Female; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Isoxazoles; Kindling, N | 1985 |
Ventromedial thalamic lesions and seizure susceptibility.
Topics: Animals; Disease Susceptibility; Flurothyl; gamma-Aminobutyric Acid; Male; Neural Pathways; Rats; Ra | 1985 |
Continuous release of diazepam: electrophysiological, biochemical and behavioral consequences.
Topics: Animals; Bicuculline; Brain; Delayed-Action Preparations; Diazepam; gamma-Aminobutyric Acid; Male; R | 1985 |
Inhibition of intrathecally administered picrotoxin- and bicuculline-induced convulsions in mice by pipecolic acid or GABA.
Topics: Animals; Bicuculline; gamma-Aminobutyric Acid; Injections, Spinal; Male; Mice; Nipecotic Acids; Picr | 1985 |
Electroencephalographic study of SR 95103, a GABAA antagonist: interaction with inhibitory amino acids and muscimol.
Topics: Animals; Drug Interactions; Electroencephalography; gamma-Aminobutyric Acid; Glycine; Male; Muscimol | 1985 |
Effects of L-lysine and its metabolites on pentylenetetrazol-induced seizures.
Topics: 2-Aminoadipic Acid; Animals; Anticonvulsants; gamma-Aminobutyric Acid; Lysine; Male; Mice; Pentylene | 1985 |
A possible role of a GABAergic mechanism in the convulsant action of RO5-4864.
Topics: Animals; Benzodiazepinones; Bicuculline; Convulsants; Dose-Response Relationship, Drug; GABA Antagon | 1985 |
Non involvement of gamma-aminobutyric acid in catechol-induced seizures.
Topics: Animals; Carbachol; Diazepam; Female; gamma-Aminobutyric Acid; Mice; Muscles; Phenobarbital; Picroto | 1986 |
Effects of gamma-aminobutyric acid (GABA) receptor agonists on the neurotoxicity and anticonvulsant activity of barbiturates in mice.
Topics: Animals; Anticonvulsants; Baclofen; Barbiturates; Dose-Response Relationship, Drug; Drug Synergism; | 1986 |
Effect of ethosuximide alone and in combination with gamma-aminobutyric acid receptor agonists on brain gamma-aminobutyric acid concentration, anticonvulsant activity and neurotoxicity in mice.
Topics: Animals; Brain Chemistry; Ethosuximide; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Mice, Inbre | 1986 |
Anticonvulsant profile of drugs which facilitate GABAergic transmission on convulsions mediated by a GABAergic mechanism.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Dose-Response Relationship, Drug; Drug Interactions | 1986 |
Genetic influences on GABA-related seizures.
Topics: 3-Mercaptopropionic Acid; Animals; Female; Flurothyl; gamma-Aminobutyric Acid; Genetics, Behavioral; | 1986 |
Role of the substantia nigra in GABA-mediated anticonvulsant actions.
Topics: Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; Brain Diseases; Denervation; D | 1986 |
Cerebellar cyclic nucleotides and the development of convulsion, with reference to the anticonvulsant activity of diazepam.
Topics: Animals; Anticonvulsants; Bucladesine; Cerebellum; Diazepam; Dibutyryl Cyclic GMP; Dose-Response Rel | 1986 |
Effects of pentylenetetrazol on GABA-A/benzodiazepine/picrotoxinin receptor complexes in rat brain regions.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; C | 1986 |
The effects of drugs acting at the GABAA-receptor/ionophore after chemical kindling with the benzodiazepine receptor ligand FG 7142.
Topics: Animals; Bicuculline; Body Temperature; Carbolines; gamma-Aminobutyric Acid; Kindling, Neurologic; M | 1986 |
Neurobehavioral, neuroendocrine and neurochemical effects of zinc supplementation in rats.
Topics: Adrenocorticotropic Hormone; Animals; Baclofen; Behavior, Animal; beta-Endorphin; Brain; Diazepam; E | 1986 |
Effect of zinc on neuronal activity in the rat forebrain.
Topics: Action Potentials; Animals; Barium; Brain; Calcium; Cerebral Cortex; Enkephalin, Methionine; gamma-A | 1986 |
Selective and non-selective seizure related brain damage produced by kainic acid.
Topics: Animals; Brain; Brain Mapping; Deoxyglucose; Epilepsy; gamma-Aminobutyric Acid; Hippocampus; Interne | 1986 |
Behavioural and biochemical evidence for a long-lasting decrease in GABAergic function elicited by chronic administration of FG 7142.
Topics: Animals; Avoidance Learning; Behavior, Animal; Brain Chemistry; Carbolines; Cerebellum; Cerebral Cor | 1986 |
Dose pipecolic acid interact with the central GABA-ergic system?
Topics: Animals; Anticonvulsants; Brain; Brain Chemistry; gamma-Aminobutyric Acid; Male; Mice; Pipecolic Aci | 1986 |
[Effects of GABA-ergic and glycinergic agents on pentamethylenetetrazole-induced convulsions in rats submitted to repeated injections of reserpine].
Topics: Animals; gamma-Aminobutyric Acid; Glycine; Linoleic Acids; Male; Pentylenetetrazole; Psychotropic Dr | 1986 |
Fengabine, a novel antidepressant GABAergic agent. I. Activity in models for antidepressant drugs and psychopharmacological profile.
Topics: Animals; Antidepressive Agents; Avoidance Learning; Behavior, Animal; Bicuculline; Chlorophenols; Cl | 1987 |
Correlation between the enhancement of flunitrazepam binding by GABA and seizure susceptibility in mice.
Topics: 3-Mercaptopropionic Acid; Allosteric Regulation; Animals; Brain Chemistry; Dose-Response Relationshi | 1987 |
Sodium valproate, but not ethosuximide, produces use- and voltage-dependent limitation of high frequency repetitive firing of action potentials of mouse central neurons in cell culture.
Topics: Action Potentials; Animals; Carbamazepine; Cells, Cultured; Cerebral Cortex; Dose-Response Relations | 1986 |
[Synergic effect of GABA and glycine in the antagonism of convulsions caused by pentetrazole in rats. Study of glycine valproamide].
Topics: Animals; Drug Synergism; gamma-Aminobutyric Acid; Glycine; Male; Pentylenetetrazole; Rats; Rats, Inb | 1986 |
Persistent reversal of tolerance to anticonvulsant effects and GABAergic subsensitivity by a single exposure to benzodiazepine antagonist during chronic benzodiazepine administration.
Topics: Animals; Behavior, Animal; Benzodiazepines; Bicuculline; Drug Tolerance; Flumazenil; gamma-Aminobuty | 1988 |
Changes in GABA content of the brain and sensitivity to GABA-antagonists during and after repetitive treatment of rats with diphenilhydantoin.
Topics: Animals; Brain; Electroshock; GABA Antagonists; gamma-Aminobutyric Acid; Male; Pentylenetetrazole; P | 1988 |
In vivo brain dialysis of amino acids and simultaneous EEG measurements following intrahippocampal quinolinic acid injection: evidence for a dissociation between neurochemical changes and seizures.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Dialysis; Electroencephalography; gamma-Aminobutyric Aci | 1985 |
Alcohol, seizures, and epilepsy.
Topics: Alcoholic Intoxication; Alcoholism; Animals; Brain Diseases; Epilepsy; Ethanol; gamma-Aminobutyric A | 1988 |
Microinjections of GABA agonists into the amygdala complex attenuates kindled seizure expression in the rat.
Topics: Aminocaproates; Amygdala; Animals; Behavior, Animal; Cerebral Cortex; gamma-Aminobutyric Acid; Kindl | 1988 |
[Convulsions in mice after administration of a new aminolactone (FK-3)].
Topics: Animals; Drug Antagonism; gamma-Aminobutyric Acid; Glycine; Lactones; Male; Mice; Mice, Inbred Strai | 1988 |
Effects of san-huang-hsieh-hsin-tang on central monoaminergic and GABAergic systems in rats.
Topics: Animals; Brain; Catecholamines; Central Nervous System; Drugs, Chinese Herbal; gamma-Aminobutyric Ac | 1988 |
Effects of progabide on bicuculline-induced epileptic seizures in developing rats.
Topics: Aging; Animals; Anticonvulsants; Bicuculline; Female; gamma-Aminobutyric Acid; Male; Rats; Rats, Inb | 1988 |
Differences in GABA activity between ethanol withdrawal seizure prone and resistant mice.
Topics: Animals; Bicuculline; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Con | 1988 |
Submassive hepatic necrosis associated with the use of progabide: a GABA receptor agonist.
Topics: Adult; Anticonvulsants; Chemical and Drug Induced Liver Injury; Female; gamma-Aminobutyric Acid; Hum | 1988 |
Classical genetic analysis of GABA-related seizures.
Topics: 3-Mercaptopropionic Acid; Animals; Crosses, Genetic; Female; gamma-Aminobutyric Acid; Genes, Dominan | 1988 |
Evidence that alterations in gamma-aminobutyric acid and acetylcholine in rat striata and cerebella are not related to soman-induced convulsions.
Topics: Acetylcholine; Animals; Cerebellum; Corpus Striatum; gamma-Aminobutyric Acid; Kinetics; Male; Rats; | 1988 |
Animal model for evaluating the convulsive liability of beta-lactam antibiotics.
Topics: Animals; Anti-Bacterial Agents; beta-Lactams; Binding, Competitive; Cefazolin; Cilastatin; Cilastati | 1988 |
Gamma-vinyl GABA: comparison of neurochemical and anticonvulsant effects in mice.
Topics: 4-Aminobutyrate Transaminase; Amino Acids; Aminocaproates; Animals; Anticonvulsants; Brain; gamma-Am | 1988 |
Taurine inhibits wet-dog shakes and hippocampal seizures induced by opioid peptides in rats.
Topics: Animals; Convulsants; Electroencephalography; Enkephalin, Methionine; gamma-Aminobutyric Acid; Hippo | 1987 |
GABA-ergic mechanisms in the anticonvulsive activity of newly-synthesized barbiturates. I. Effects of barbiturates on the convulsive action of GABA-antagonists.
Topics: 3-Mercaptopropionic Acid; Allylglycine; Animals; Anticonvulsants; Barbiturates; Bicuculline; GABA An | 1987 |
[Effects of reserpine on the protective function of diazepam against hyperbaric oxygen-induced convulsions].
Topics: Animals; Brain; Diazepam; Dopamine; Female; gamma-Aminobutyric Acid; Hyperbaric Oxygenation; Male; N | 1987 |
Anticonvulsant effects of GABA elevation in the deep prepiriform cortex.
Topics: Aminocaproates; Animals; Anticonvulsants; Bicuculline; Cerebral Cortex; gamma-Aminobutyric Acid; Mal | 1987 |
Disappearance of neonatal seizures and low CSF GABA levels after treatment with vitamin B6.
Topics: gamma-Aminobutyric Acid; Humans; Infant; Infant, Newborn; Male; Pyridoxine; Seizures | 1987 |
GABA uptake inhibitors. Synthesis and effects on audiogenic seizures of ester prodrugs of nipecotic acid, guvacine and cis-4-hydroxynipecotic acid.
Topics: Acoustic Stimulation; Animals; Female; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Indicators | 1987 |
Effect of repeated convulsive seizures on brain gamma-aminobutyric acid metabolism in three sublines of mice differing by their response to acoustic stimulations.
Topics: Acoustic Stimulation; Animals; Brain; Brain Chemistry; gamma-Aminobutyric Acid; Male; Mice; Seizures | 1987 |
Neurotoxic effects of methylcyclopentadienyl manganese tricarbonyl (MMT) in the mouse: basis of MMT-induced seizure activity.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Corn Oil; gamma- | 1987 |
Anticonvulsant effect of intracortical, chronic infusion of GABA in kindled rats: focal seizures upon withdrawal.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Electroencephalography; gamma-Aminobutyric Aci | 1987 |
Inhibition of GABA release from slices prepared from several brain regions of rats at various times following a convulsion.
Topics: Animals; Brain; Cerebral Cortex; Depression, Chemical; Electroshock; Flurothyl; gamma-Aminobutyric A | 1987 |
The effect of repeated electroconvulsive shock on GABA synthesis and release in regions of rat brain.
Topics: Animals; Brain; Electroshock; gamma-Aminobutyric Acid; Glutamate Decarboxylase; In Vitro Techniques; | 1987 |
Inhibition of the rate of GABA synthesis in regions of rat brain following a convulsion.
Topics: Aminooxyacetic Acid; Animals; Brain; Flurothyl; gamma-Aminobutyric Acid; Gas Chromatography-Mass Spe | 1987 |
Effects of diazepam, pentobarbital, phenytoin and pentylenetetrazol on hippocampal paired-pulse inhibition in vivo.
Topics: Action Potentials; Animals; Behavior, Animal; Diazepam; Electroshock; gamma-Aminobutyric Acid; Hippo | 1986 |
Involvement of a GABAergic mechanism in the pharmacologic action of phenytoin.
Topics: Animals; Anticonvulsants; Baclofen; Electroshock; gamma-Aminobutyric Acid; Male; Mice; Phenytoin; Po | 1986 |
Age-related substantia nigra-mediated seizure facilitation.
Topics: Animals; Animals, Newborn; gamma-Aminobutyric Acid; Muscimol; Rats; Rats, Inbred Strains; Seizures; | 1986 |
Inferior colliculus neuronal response abnormalities in genetically epilepsy-prone rats: evidence for a deficit of inhibition.
Topics: Acoustic Stimulation; Animals; Bicuculline; gamma-Aminobutyric Acid; Inferior Colliculi; Neurons; Ra | 1986 |
Anatomical changes of the GABAergic system in the inferior colliculus of the genetically epilepsy-prone rat.
Topics: Acoustic Stimulation; Animals; Epilepsy; gamma-Aminobutyric Acid; Histocytochemistry; Inferior Colli | 1986 |
gamma-Acetylenic GABA antagonizes the decrease in synaptosomal GABA concentrations but not the seizures induced by 3-mercaptopropionic acid in rats.
Topics: 3-Mercaptopropionic Acid; Alkynes; Aminocaproates; Animals; Female; gamma-Aminobutyric Acid; Rats; R | 1986 |
GABAergic influences on barbital withdrawal induced convulsions.
Topics: Animals; Barbital; Barbiturates; Corpus Striatum; gamma-Aminobutyric Acid; Male; Pentobarbital; Rats | 1986 |
Genetic differences in the effects of delta-aminolevulinic acid on seizure latency in mice.
Topics: Aminolevulinic Acid; Animals; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Levulinic Acids; | 1986 |
Suppression of amygdaloid kindled seizure and regional brain GABA content.
Topics: Amygdala; Animals; Brain; Cyclohexanecarboxylic Acids; gamma-Aminobutyric Acid; Hippocampus; Kindlin | 1985 |
The specific protective effect of diazepam and valproate against isoniazid-induced seizures is not correlated with increased GABA levels.
Topics: Amino Acids; Animals; Diazepam; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Isoniazid | 1985 |
GABAergic and dopaminergic systems of the substantia nigra and amygdaloid kindling in cats.
Topics: Aminocaproates; Amygdala; Animals; Cats; Differential Threshold; Dopamine; gamma-Aminobutyric Acid; | 1985 |
[Effect of chlorgyline on gamma-aminobutyric acid levels in hyperoxia].
Topics: Animals; Brain; Clorgyline; Female; gamma-Aminobutyric Acid; Male; Oxygen; Propylamines; Rats; Seizu | 1986 |
Age-dependent changes in brain GABA turnover rates in two inbred strains of mice.
Topics: Animals; Brain; gamma-Aminobutyric Acid; Hypothalamus; Kinetics; Male; Mice; Mice, Inbred C57BL; Mic | 1985 |
Electroencephalographic consequences of sodium dehydrocholate-induced blood-brain barrier disruption: Part 2. Generation and propagation of spike activity after the topical application of sodium dehydrocholate.
Topics: Administration, Topical; Animals; Blood-Brain Barrier; Brain; Cerebral Cortex; Dehydrocholic Acid; E | 1985 |
Comparison of the anticonvulsant effects of two novel GABA uptake inhibitors and diazepam in amygdaloid kindled rats.
Topics: Amygdala; Animals; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Female; gamma-Aminob | 1985 |
Coping and seizure susceptibility: control over shock protects against bicuculline-induced seizures.
Topics: Adaptation, Psychological; Animals; Bicuculline; Electroshock; Escape Reaction; gamma-Aminobutyric A | 1985 |
GABA and phospholipids in penicillin-induced seizures.
Topics: Action Potentials; Animals; Brain; gamma-Aminobutyric Acid; Male; Penicillins; Phosphatidylcholines; | 1985 |
Anticonvulsant action of GABA agonists and prodrugs on minor and major seizures in epileptic gerbils. Comparison with mouse models of seizure states.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Female; gamma-Aminobutyric Acid; Ger | 1985 |
[Change in the activity of a cell-free protein-synthesizing system with different functional states of the central nervous system].
Topics: Anesthesia; Animals; Brain; Cell-Free System; Chlorpromazine; gamma-Aminobutyric Acid; Hexobarbital; | 1972 |
Development of an expression which relates the excitable state of the brain to the level of GAD activity and GABA content, with particular reference to the action of hydrazine and its derivatives.
Topics: Aminobutyrates; Animals; Brain; Carboxy-Lyases; Chickens; Dose-Response Relationship, Drug; Fasting; | 1974 |
Seizure inhibition and REM sleep: a possible neurohumoral relationship.
Topics: Acetylcholine; Animals; Cats; Electric Stimulation; Female; gamma-Aminobutyric Acid; Hippocampus; Ma | 1974 |
Effect of the convulsive agent 3-mercaptopropionic acid on the levels of GABA, other amino acids and glutamate decarboxylase in different regions of the rat brain.
Topics: Acetyltransferases; Amino Acids; Aminobutyrates; Animals; Brain; Brain Chemistry; Carboxy-Lyases; Ce | 1974 |
Possible role of cerebral amino acids in acute neurotoxic effects of DDT in mice.
Topics: Amino Acids; Animals; Behavior, Animal; Brain; Brain Chemistry; DDT; gamma-Aminobutyric Acid; Glycin | 1974 |
Metabolism of glucose in cerebral cortex of rat in leptazol-induced convulsions and effect of gamma-aminobutyric acid on the same.
Topics: Aminobutyrates; Animals; Cerebral Cortex; gamma-Aminobutyric Acid; Glucose; Glutamates; Glutamine; I | 1974 |
Effect of barbiturates and isoniazid on cerebral hemisphere gamma-aminobutyric acid content in pp' DDT treated mice.
Topics: Aminobutyrates; Animals; Anticonvulsants; Barbiturates; Behavior, Animal; Brain Chemistry; DDT; Drug | 1974 |
The role of astroglia as modulators of neuronal function in cerebral cortex: comparative data, and observations in vivo and in vitro in fluid, electrolyte and amino acid interrelationships.
Topics: Acetylcholinesterase; Animals; Astrocytes; Biological Transport, Active; Carbonic Anhydrases; Carbox | 1973 |
Proceedings: Anticonvulsive action of homotaurine and taurine.
Topics: Animals; Anticonvulsants; Cats; Electroencephalography; gamma-Aminobutyric Acid; Glycine; Hyperbaric | 1974 |