gamma-aminobutyric acid has been researched along with Seizures, Febrile in 30 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
Seizures, Febrile: Seizures that occur during a febrile episode. It is a common condition, affecting 2-5% of children aged 3 months to five years. An autosomal dominant pattern of inheritance has been identified in some families. The majority are simple febrile seizures (generally defined as generalized onset, single seizures with a duration of less than 30 minutes). Complex febrile seizures are characterized by focal onset, duration greater than 30 minutes, and/or more than one seizure in a 24 hour period. The likelihood of developing epilepsy (i.e., a nonfebrile seizure disorder) following simple febrile seizures is low. Complex febrile seizures are associated with a moderately increased incidence of epilepsy. (From Menkes, Textbook of Child Neurology, 5th ed, p784)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Rare inherited missense variants in SLC32A1, the gene that encodes the vesicular gamma-aminobutyric acid (GABA) transporter, have recently been shown to cause genetic epilepsy with febrile seizures plus." | 4.12 | De Novo Missense Variants in SLC32A1 Cause a Developmental and Epileptic Encephalopathy Due to Impaired GABAergic Neurotransmission. ( Abou Jamra, R; Bilan, F; Brose, N; Bupp, C; Ganapathi, M; Henderson, LB; Le Guyader, G; Lemke, JR; Pereira, EM; Platzer, K; Sticht, H; Taschenberger, H; Wojcik, SM, 2022) |
| "In 14 children with epilepsy, 51 with febrile convulsions and 22 with meningitis gamma-aminobutyric acid (GABA) concentrations in lumbar CSF were determined." | 3.66 | Low CSF GABA concentration in children with febrile convulsions, untreated epilepsy, and meningitis. ( Löscher, W; Rating, D; Siemes, H, 1983) |
| "Familial febrile seizures is caused by mild loss-of-function mutations in NaV1." | 2.46 | NaV1.1 channels and epilepsy. ( Catterall, WA; Kalume, F; Oakley, JC, 2010) |
| "Generalized epilepsy with febrile seizures plus (GEFS+) is caused by missense mutations in NaV1." | 2.46 | NaV1.1 channels and epilepsy. ( Catterall, WA; Kalume, F; Oakley, JC, 2010) |
| "The causes of epilepsies and epileptic seizures are multifactorial." | 2.46 | Mutations affecting GABAergic signaling in seizures and epilepsy. ( Galanopoulou, AS, 2010) |
| "Complex febrile seizures (FSs) lead to a high risk of intractable temporal lobe epilepsy during adulthood, yet the pathological process of complex FSs is largely unknown." | 1.56 | Microglial Displacement of GABAergic Synapses Is a Protective Event during Complex Febrile Seizures. ( Chen, Z; Dai, H; Feng, B; Hu, W; Shi, P; Trapp, BD; Wan, Y; Xu, C; You, Y; Yu, J, 2020) |
| "Febrile seizures are a paediatric condition which affects 2-5 % of children worldwide with prolonged febrile seizures (PFS) being found to cause long-term complications and predispose patients to other neurological conditions later in life." | 1.51 | Acetylcholine receptor agonist effect on seizure activity and GABAergic mechanisms involved in prolonged febrile seizure development in an animal model. ( Mabandla, MV; Rakgantsho, C, 2019) |
| "Using a rat model of complex febrile seizures, which are thought to be a precipitating insult of TLE later in life, we report that aberrant migration of neonatal-generated granule cells results in granule cell ectopia that persists into adulthood." | 1.38 | GABAergic excitation after febrile seizures induces ectopic granule cells and adult epilepsy. ( Ichikawa, J; Ikegaya, Y; Koyama, R; Matsuki, N; Miyamoto, D; Muramatsu, R; Sasaki, T; Tao, K, 2012) |
| "Children who experience complex febrile seizures are at a higher risk of subsequent epileptic episodes, and they may require therapy." | 1.37 | Molecular alterations underlying epileptogenesis after prolonged febrile seizure and modulation by erythropoietin. ( Chu, K; Jeon, D; Jung, KH; Kang, KM; Kim, JH; Kim, M; Kim, S; Lee, SK; Lee, ST; Park, KI; Roh, JK, 2011) |
| "Febrile seizures are the most common types of seizure in children, and are generally considered to be benign." | 1.36 | N-methyl-D-aspartate, hyperpolarization-activated cation current (Ih) and gamma-aminobutyric acid conductances govern the risk of epileptogenesis following febrile seizures in rat hippocampus. ( Awad, PN; Carmant, L; Di Cristo, G; Lema, P; Ouardouz, M, 2010) |
| "However, febrile seizures in children with dysgenesis have been associated with the development of temporal lobe epilepsy." | 1.36 | N-methyl-D-aspartate, hyperpolarization-activated cation current (Ih) and gamma-aminobutyric acid conductances govern the risk of epileptogenesis following febrile seizures in rat hippocampus. ( Awad, PN; Carmant, L; Di Cristo, G; Lema, P; Ouardouz, M, 2010) |
| "Febrile seizures are the most common seizure type in children, and hyperthermia may contribute to seizure generation during fever." | 1.35 | Effects of temperature elevation on neuronal inhibition in hippocampal neurons of immature and mature rats. ( Leung, LS; Qu, L, 2009) |
| "Here we describe a family that has generalized epilepsy with febrile seizures plus (GEFS(+)), including an individual with severe myoclonic epilepsy of infancy, in whom a third GABA(A)-receptor gamma2-subunit mutation was found." | 1.31 | Truncation of the GABA(A)-receptor gamma2 subunit in a family with generalized epilepsy with febrile seizures plus. ( Berkovic, SF; Bowser, DN; Dibbens, LM; Harkin, LA; Mulley, JC; Petrou, S; Phillips, F; Richards, MC; Scheffer, IE; Singh, R; Wallace, RH; Williams, DA, 2002) |
| "In 14 children with epilepsy, 51 with febrile convulsions and 22 with meningitis gamma-aminobutyric acid (GABA) concentrations in lumbar CSF were determined." | 1.27 | Low CSF GABA concentration in children with febrile convulsions, untreated epilepsy, and meningitis. ( Löscher, W; Rating, D; Siemes, H, 1983) |
| "The CSF GABA levels in children with febrile seizures were not significantly different from those in controls and children with afebrile or recurrent febrile seizures." | 1.27 | gamma-Aminobutyric acid in CSF of children with febrile seizures. ( Berry, H; Ebert, J; Fogelson, MH; Knight, M; Parish, RA, 1985) |
| "In 23 children with febrile convulsions the concentration of gamma-aminobutyric acid (GABA) in lumbar cerebrospinal fluid (CSF) was measured by a radioreceptor assay." | 1.26 | GABA in cerebrospinal fluid of children with febrile convulsions. ( Löscher, W; Rating, D; Siemes, H, 1981) |
| "In this study the pentetrazole seizure threshold of dogs was compared with the concentration of GABA in the CSF and blood plasma." | 1.26 | Relationship between GABA concentrations in cerebrospinal fluid and seizure excitability. ( Löscher, W, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (13.33) | 18.7374 |
| 1990's | 4 (13.33) | 18.2507 |
| 2000's | 7 (23.33) | 29.6817 |
| 2010's | 12 (40.00) | 24.3611 |
| 2020's | 3 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, X | 1 |
| Yang, F | 1 |
| Deng, L | 1 |
| Qiu, D | 1 |
| Liu, Y | 1 |
| Kang, Y | 1 |
| Platzer, K | 1 |
| Sticht, H | 1 |
| Bupp, C | 1 |
| Ganapathi, M | 1 |
| Pereira, EM | 1 |
| Le Guyader, G | 1 |
| Bilan, F | 1 |
| Henderson, LB | 1 |
| Lemke, JR | 1 |
| Taschenberger, H | 1 |
| Brose, N | 1 |
| Abou Jamra, R | 1 |
| Wojcik, SM | 1 |
| Wan, Y | 1 |
| Feng, B | 2 |
| You, Y | 1 |
| Yu, J | 1 |
| Xu, C | 1 |
| Dai, H | 1 |
| Trapp, BD | 1 |
| Shi, P | 1 |
| Chen, Z | 2 |
| Hu, W | 1 |
| Fazeli, W | 1 |
| Zappettini, S | 1 |
| Marguet, SL | 1 |
| Grendel, J | 1 |
| Esclapez, M | 1 |
| Bernard, C | 1 |
| Isbrandt, D | 1 |
| Rakgantsho, C | 1 |
| Mabandla, MV | 1 |
| Todd, E | 1 |
| Gurba, KN | 1 |
| Botzolakis, EJ | 1 |
| Stanic, AK | 1 |
| Macdonald, RL | 1 |
| Dai, YJ | 1 |
| Wu, DC | 1 |
| Hou, WW | 1 |
| Xu, CL | 1 |
| Ohtsu, H | 1 |
| Hu, WW | 1 |
| Petruccelli, E | 1 |
| Lansdon, P | 1 |
| Kitamoto, T | 1 |
| Qu, L | 3 |
| Leung, LS | 3 |
| Catterall, WA | 1 |
| Kalume, F | 1 |
| Oakley, JC | 1 |
| Ouardouz, M | 1 |
| Lema, P | 1 |
| Awad, PN | 1 |
| Di Cristo, G | 1 |
| Carmant, L | 1 |
| Galanopoulou, AS | 1 |
| Jung, KH | 1 |
| Chu, K | 1 |
| Lee, ST | 1 |
| Park, KI | 1 |
| Kim, JH | 1 |
| Kang, KM | 1 |
| Kim, S | 1 |
| Jeon, D | 1 |
| Kim, M | 1 |
| Lee, SK | 1 |
| Roh, JK | 1 |
| Koyama, R | 1 |
| Tao, K | 1 |
| Sasaki, T | 1 |
| Ichikawa, J | 1 |
| Miyamoto, D | 1 |
| Muramatsu, R | 1 |
| Matsuki, N | 1 |
| Ikegaya, Y | 1 |
| Hino, H | 1 |
| Takahashi, H | 1 |
| Suzuki, Y | 1 |
| Tanaka, J | 1 |
| Ishii, E | 1 |
| Fukuda, M | 1 |
| Swijsen, A | 1 |
| Avila, A | 1 |
| Brône, B | 1 |
| Janssen, D | 1 |
| Hoogland, G | 1 |
| Rigo, JM | 1 |
| Chen, K | 1 |
| Ratzliff, A | 1 |
| Hilgenberg, L | 1 |
| Gulyás, A | 1 |
| Freund, TF | 1 |
| Smith, M | 1 |
| Dinh, TP | 1 |
| Piomelli, D | 1 |
| Mackie, K | 1 |
| Soltesz, I | 1 |
| Tapia, R | 2 |
| Liu, X | 1 |
| Wu, C | 1 |
| Ragavendran, JV | 1 |
| Sriram, D | 1 |
| Kotapati, S | 1 |
| Stables, J | 1 |
| Yogeeswari, P | 1 |
| Rating, D | 2 |
| Siemes, H | 2 |
| Löscher, W | 3 |
| Nagaki, S | 2 |
| Minatogawa, Y | 1 |
| Sadamatsu, M | 1 |
| Kato, N | 1 |
| Osawa, M | 1 |
| Fukuyama, Y | 1 |
| Walker, MC | 1 |
| Kullmann, DM | 1 |
| Harkin, LA | 1 |
| Bowser, DN | 1 |
| Dibbens, LM | 1 |
| Singh, R | 1 |
| Phillips, F | 1 |
| Wallace, RH | 1 |
| Richards, MC | 1 |
| Williams, DA | 1 |
| Mulley, JC | 1 |
| Berkovic, SF | 1 |
| Scheffer, IE | 1 |
| Petrou, S | 1 |
| Arias, C | 1 |
| Valero, H | 1 |
| Schmiegelow, K | 1 |
| Johnsen, AH | 1 |
| Ebbesen, F | 1 |
| Mortensen, T | 1 |
| Berg, AM | 1 |
| Thorn, I | 1 |
| Skov, L | 1 |
| Ostergaard, JR | 1 |
| Sørensen, O | 1 |
| Knight, M | 1 |
| Ebert, J | 1 |
| Parish, RA | 1 |
| Berry, H | 1 |
| Fogelson, MH | 1 |
2 reviews available for gamma-aminobutyric acid and Seizures, Febrile
| Article | Year |
|---|---|
NaV1.1 channels and epilepsy.
Topics: Animals; Channelopathies; Child; Epilepsy; gamma-Aminobutyric Acid; Humans; Ion Channel Gating; Mice | 2010 |
Mutations affecting GABAergic signaling in seizures and epilepsy.
Topics: Angelman Syndrome; Animals; Channelopathies; Chloride Channels; Chlorides; CLC-2 Chloride Channels; | 2010 |
1 trial available for gamma-aminobutyric acid and Seizures, Febrile
| Article | Year |
|---|---|
Gamma-aminobutyric acid concentration in lumbar cerebrospinal fluid from patients with febrile convulsions and controls.
Topics: Adolescent; Child; Child, Preschool; Female; gamma-Aminobutyric Acid; Humans; Infant; Infant, Newbor | 1990 |
27 other studies available for gamma-aminobutyric acid and Seizures, Febrile
| Article | Year |
|---|---|
Liraglutide Is Protective against Brain Injury in Mice with Febrile Seizures by Inhibiting Inflammatory Factors.
Topics: Animals; Brain Injuries; gamma-Aminobutyric Acid; Glucagon-Like Peptide 1; Glutamates; Humans; Inter | 2022 |
De Novo Missense Variants in SLC32A1 Cause a Developmental and Epileptic Encephalopathy Due to Impaired GABAergic Neurotransmission.
Topics: Amino Acid Transport Systems; Animals; Epilepsy; Epilepsy, Generalized; gamma-Aminobutyric Acid; Mic | 2022 |
Microglial Displacement of GABAergic Synapses Is a Protective Event during Complex Febrile Seizures.
Topics: Animals; Cerebral Cortex; Disease Susceptibility; gamma-Aminobutyric Acid; Imaging, Three-Dimensiona | 2020 |
Early-life exposure to caffeine affects the construction and activity of cortical networks in mice.
Topics: Animals; Animals, Newborn; Caffeine; Central Nervous System Stimulants; Cerebral Cortex; Dendrites; | 2017 |
Acetylcholine receptor agonist effect on seizure activity and GABAergic mechanisms involved in prolonged febrile seizure development in an animal model.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Cholinergic Agonists; Disease Models, Animal; Fema | 2019 |
GABAA receptor biogenesis is impaired by the γ2 subunit febrile seizure-associated mutation, GABRG2(R177G).
Topics: Cell Membrane; Conserved Sequence; Cycloheximide; Endoplasmic Reticulum; Endoplasmic Reticulum-Assoc | 2014 |
Protective effect of carnosine on febrile seizures in immature mice.
Topics: Animals; Anticonvulsants; Carnosine; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamic Acid; Hippoc | 2015 |
Exaggerated Nighttime Sleep and Defective Sleep Homeostasis in a Drosophila Knock-In Model of Human Epilepsy.
Topics: Animals; Animals, Genetically Modified; Circadian Rhythm; Disease Models, Animal; Disease Susceptibi | 2015 |
Mechanisms of hyperthermia-induced depression of GABAergic synaptic transmission in the immature rat hippocampus.
Topics: Adenylyl Cyclases; Aging; Animals; Animals, Newborn; Body Temperature; Cyclic AMP-Dependent Protein | 2008 |
Effects of temperature elevation on neuronal inhibition in hippocampal neurons of immature and mature rats.
Topics: Aging; Animals; Animals, Newborn; Body Temperature; Cell Differentiation; Dentate Gyrus; Female; Fev | 2009 |
N-methyl-D-aspartate, hyperpolarization-activated cation current (Ih) and gamma-aminobutyric acid conductances govern the risk of epileptogenesis following febrile seizures in rat hippocampus.
Topics: Animals; Animals, Newborn; Bicuculline; Biophysics; Cyclic Nucleotide-Gated Cation Channels; Disease | 2010 |
Molecular alterations underlying epileptogenesis after prolonged febrile seizure and modulation by erythropoietin.
Topics: Animals; Animals, Newborn; Anticonvulsants; Apoptosis; Blood-Brain Barrier; Brain; CD11b Antigen; Ce | 2011 |
GABAergic excitation after febrile seizures induces ectopic granule cells and adult epilepsy.
Topics: Animals; Animals, Suckling; Brain Diseases; Bumetanide; Cell Lineage; Cell Movement; Choristoma; Den | 2012 |
Anticonvulsive effect of paeoniflorin on experimental febrile seizures in immature rats: possible application for febrile seizures in children.
Topics: Animals; Anticonvulsants; Benzoates; Bridged-Ring Compounds; Calcium; Cells, Cultured; Child; gamma- | 2012 |
Experimental early-life febrile seizures induce changes in GABA(A) R-mediated neurotransmission in the dentate gyrus.
Topics: Age Factors; Animals; Dentate Gyrus; gamma-Aminobutyric Acid; Inhibitory Postsynaptic Potentials; Ma | 2012 |
Long-term plasticity of endocannabinoid signaling induced by developmental febrile seizures.
Topics: Action Potentials; Animals; Blotting, Western; Cannabinoid Receptor Modulators; Cells, Cultured; Chr | 2003 |
Putting the heat on febrile seizures.
Topics: Brain; Child; Child, Preschool; gamma-Aminobutyric Acid; Humans; Hydrogen-Ion Concentration; Recepto | 2006 |
Hyperthermia decreases GABAergic synaptic transmission in hippocampal neurons of immature rats.
Topics: Animals; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Fever; gamma | 2007 |
Newer GABA derivatives for the treatment of epilepsy including febrile seizures: a bioisosteric approach.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Dru | 2008 |
Low CSF GABA concentration in children with febrile convulsions, untreated epilepsy, and meningitis.
Topics: Adolescent; Child; Child, Preschool; Epilepsy; Female; gamma-Aminobutyric Acid; Humans; Infant; Male | 1983 |
GABA in cerebrospinal fluid of children with febrile convulsions.
Topics: Child, Preschool; Female; gamma-Aminobutyric Acid; Humans; Infant; Male; Seizures, Febrile; Synaptic | 1981 |
Relationship between GABA concentrations in cerebrospinal fluid and seizure excitability.
Topics: Animals; Dogs; Epilepsy; Female; gamma-Aminobutyric Acid; Male; Pentylenetetrazole; Seizures; Seizur | 1982 |
The role of vasopressin, somatostatin and GABA in febrile convulsion in rat pups.
Topics: Animals; Arginine Vasopressin; Brain Chemistry; gamma-Aminobutyric Acid; Male; Rats; Rats, Wistar; S | 1996 |
Febrile convulsions: a 'benign' condition?
Topics: Animals; Child, Preschool; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; | 1999 |
Truncation of the GABA(A)-receptor gamma2 subunit in a family with generalized epilepsy with febrile seizures plus.
Topics: Animals; Base Sequence; Cell Line; Codon, Terminator; Electrophysiology; Endoplasmic Reticulum; Epil | 2002 |
Inhibition of brain glutamate decarboxylase activity is related to febrile seizures in rat pups.
Topics: Animals; Animals, Newborn; Brain; Chromatography, High Pressure Liquid; Disease Susceptibility; gamm | 1992 |
gamma-Aminobutyric acid in CSF of children with febrile seizures.
Topics: Child; Child, Preschool; Fever; gamma-Aminobutyric Acid; Humans; Infant; Recurrence; Seizures, Febri | 1985 |