gamma-aminobutyric acid and Scoliosis studies

gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.

Scoliosis: An appreciable lateral deviation in the normally straight vertical line of the spine. (Dorland, 27th ed)

Research Excerpts

Excerpt	Relevance	Reference
"Adolescent patients undergoing idiopathic scoliosis surgery were randomized to receive a single preoperative dose of gabapentin 600 mg or placebo."	9.19	Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial. ( Campbell, F; Mayell, A; Peliowski, A; Srinivasan, I, 2014)
"A single preoperative dose of gabapentin did not show a significant difference in opioid consumption or pain scores in adolescents undergoing idiopathic scoliosis surgery."	9.19	Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial. ( Campbell, F; Mayell, A; Peliowski, A; Srinivasan, I, 2014)
"Adolescent patients undergoing idiopathic scoliosis surgery were randomized to receive a single preoperative dose of gabapentin 600 mg or placebo."	5.19	Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial. ( Campbell, F; Mayell, A; Peliowski, A; Srinivasan, I, 2014)
"A single preoperative dose of gabapentin did not show a significant difference in opioid consumption or pain scores in adolescents undergoing idiopathic scoliosis surgery."	5.19	Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial. ( Campbell, F; Mayell, A; Peliowski, A; Srinivasan, I, 2014)
"Gabapentin has opioid-sparing effects in adult surgical patients, but no reported studies have involved children and adolescents."	2.75	Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial. ( Berens, RJ; Czarnecki, ML; Hainsworth, KR; Lyon, RM; Nelson, TJ; Rusy, LM; Tassone, JC; Thometz, JG; Weisman, SJ, 2010)
"Variation in postoperative pain management for children undergoing PSF for AIS likely impacts outcomes."	1.46	The Association Between Adjuvant Pain Medication Use and Outcomes Following Pediatric Spinal Fusion. ( Cohen, M; Erickson, M; Errico, T; McLeod, L; Rosenberg, RE; Trzcinski, S, 2017)

Research

Studies (3)

Authors

Clinical Trials (6)

Trial Overview

Trial Outcomes

Post-operative Opioid Consumption (mg/kg)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	3 (100.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Mayell, A	1
Srinivasan, I	1
Campbell, F	1
Peliowski, A	1
Rosenberg, RE	1
Trzcinski, S	1
Cohen, M	1
Erickson, M	1
Errico, T	1
McLeod, L	1
Rusy, LM	1
Hainsworth, KR	1
Nelson, TJ	1
Czarnecki, ML	1
Tassone, JC	1
Thometz, JG	1
Lyon, RM	1
Berens, RJ	1
Weisman, SJ	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Use of Gabapentin as Preanesthetic Medication in Oncologic Children Undergoing in Fast Procedures With Sevofluran[NCT03681574]	Phase 4	135 participants (Actual)	Interventional	2017-07-01	Completed
Placebo Controlled, Randomized,Gabapentin as Adjuvant for Postoperative Pain in Pediatric Orthopedic Surgery[NCT03005483]	Phase 4	40 participants (Actual)	Interventional	2014-01-31	Completed
Efficacy of Gabapentin as Adjuvant for Postoperative Pain in Pediatric Thoracic Surgery - a Randomized Quadruple Blind Study[NCT03393702]	Phase 4	104 participants (Actual)	Interventional	2017-05-09	Completed
Perioperative Methadone Use to Decrease Opioid Requirement in Pediatric Spinal Fusion Patients[NCT02558010]	Phase 3	58 participants (Actual)	Interventional	2016-02-01	Completed
Gabapentin Regimens and Their Effects on Opioid Consumption[NCT03334903]	Phase 4	77 participants (Actual)	Interventional	2018-05-15	Completed
Pain Control in Pediatric Posterior Spine Fusion Patients: The Effect of Gabapentin on Post-operative Opioid Use and Patient Satisfaction[NCT01977937]	Phase 4	55 participants (Actual)	Interventional	2013-11-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Total amount of opioids consumed during the first 72 hours after surgery. (NCT02558010)
Timeframe: 72 hours

"VAS Score 1: How Much Pain do You Feel in Your Operative Site When Resting?"

Intervention	mg/kg (Median)
Methadone Group	0.267
Control Group	0.340

Surgical site pain. Scale 0-10, with 0 best and 10 worst (NCT03334903)
Timeframe: 2-3 months after surgery (at 2nd postoperative appointment)

"VAS Score 2: How Much Pain do You Feel in Your Operative Site When Moving?"

Intervention	score on 10-point scale (Mean)
Standard of Care	2.26
Postoperative Gabapentin Regimen	2.46

Surgical site pain. Scale 0-10, with 0 best and 10 worst. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

"VAS Score 3: How Well Are You Sleeping?"

Intervention	score on a 10-point scale (Mean)
Standard of Care	3.84
Postoperative Gabapentin Regimen	3.54

Sleep quality. Scale 0-10 with 0 worst and 10 best. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

"VAS Score 4: How Bad is Your Nausea?"

Intervention	score on a 10-point scale (Mean)
Standard of Care	5.73
Postoperative Gabapentin Regimen	6.38

Nausea. Scale 0-10, with 0 best and 10 worst. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

"VAS Score 5: How Satisfied Are You With Your Pain Management?"

Intervention	score on a 10-point scale (Mean)
Standard of Care	0.36
Postoperative Gabapentin Regimen	0.17

Satisfaction. Scale 0-10 with 0 worst and 10 best. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

Days Taking Opioids

Intervention	score on a 10-point scale (Mean)
Standard of Care	7.83
Postoperative Gabapentin Regimen	8.48

Number of days until patients are finished consuming opioid medications after discharge. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

Opioid Consumption

Intervention	days (Mean)
Standard of Care	14.8
Postoperative Gabapentin Regimen	18.7

Mean opioid consumption, measured in mg of morphine equivalents. (NCT03334903)
Timeframe: 2-3 months following surgery (total amount measured at second postoperative appointment; means assessed afterwards).

Difference in Pain Control When Adding Gabapentin to a Multimodal Pain Management Protocol in Pediatric Post-operative Posterior Spinal Fusion Patients.

Intervention	morphine equivalents (Mean)
Standard of Care	287.0
Postoperative Gabapentin Regimen	281.1

"Patients will rate their pain using the Visual Analog Pain Scale (VAS). The VAS is a 10 cm line with anchors of no pain and worst pain imaginable. Patients rate their pain by marking on the 10 cm line where they feel their pain is at the time. The mark is then measured according to where it is along the 10 cm line and reported (range is 0.0 at the no pain end on the left up to 10.0 at the worst pain imaginable on the right). Lower pain scores on the VAS scale are considered a better outcome. The numbers seen in the outcome measure data table below represent an average of the total postoperative VAS scores recorded for each patient from each arm for the duration of their hospital stay." (NCT01977937)
Timeframe: five days

Opiate Usage in the Gabapentin Group Versus Control.

Intervention	pain score on a scale (Mean)
Gabapentin	2.46
Simple Syrup	3.46

Total the amount of Hydromorphone and Oxycodone used in milligrams per kilogram in each patient post-operatively, convert this amount to morphine equivalents, and determine if there is a significant difference between the Gabapentin versus Placebo group. (NCT01977937)
Timeframe: Five Days

Article	Year
Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial. Paediatric anaesthesia, 2014, Volume: 24, Issue:12 Topics: Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Cyclohexanecarbox	2014
Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial. Paediatric anaesthesia, 2014, Volume: 24, Issue:12 Topics: Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Cyclohexanecarbox	2014
Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial. Paediatric anaesthesia, 2014, Volume: 24, Issue:12 Topics: Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Cyclohexanecarbox	2014
Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial. Paediatric anaesthesia, 2014, Volume: 24, Issue:12 Topics: Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Cyclohexanecarbox	2014
Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial. Paediatric anaesthesia, 2014, Volume: 24, Issue:12 Topics: Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Cyclohexanecarbox	2014
Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial. Paediatric anaesthesia, 2014, Volume: 24, Issue:12 Topics: Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Cyclohexanecarbox	2014
Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial. Paediatric anaesthesia, 2014, Volume: 24, Issue:12 Topics: Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Cyclohexanecarbox	2014
Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial. Paediatric anaesthesia, 2014, Volume: 24, Issue:12 Topics: Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Cyclohexanecarbox	2014
Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial. Paediatric anaesthesia, 2014, Volume: 24, Issue:12 Topics: Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Cyclohexanecarbox	2014
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial. Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5 Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch	2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial. Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5 Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch	2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial. Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5 Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch	2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial. Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5 Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch	2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial. Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5 Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch	2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial. Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5 Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch	2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial. Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5 Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch	2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial. Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5 Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch	2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial. Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5 Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch	2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial. Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5 Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch	2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial. Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5 Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch	2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial. Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5 Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch	2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial. Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5 Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch	2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial. Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5 Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch	2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial. Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5 Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch	2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial. Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5 Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch	2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial. Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5 Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch	2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial. Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5 Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch	2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial. Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5 Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch	2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial. Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5 Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch	2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial. Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5 Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch	2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial. Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5 Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch	2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial. Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5 Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch	2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial. Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5 Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch	2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial. Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5 Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch	2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial. Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5 Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch	2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial. Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5 Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch	2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial. Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5 Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch	2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial. Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5 Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch	2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial. Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5 Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch	2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial. Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5 Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch	2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial. Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5 Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch	2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial. Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5 Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch	2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial. Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5 Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch	2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial. Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5 Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch	2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial. Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5 Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch	2010

gamma-aminobutyric acid and Scoliosis