gamma-aminobutyric acid has been researched along with Scoliosis in 3 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
Scoliosis: An appreciable lateral deviation in the normally straight vertical line of the spine. (Dorland, 27th ed)
Excerpt | Relevance | Reference |
---|---|---|
"Adolescent patients undergoing idiopathic scoliosis surgery were randomized to receive a single preoperative dose of gabapentin 600 mg or placebo." | 9.19 | Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial. ( Campbell, F; Mayell, A; Peliowski, A; Srinivasan, I, 2014) |
"A single preoperative dose of gabapentin did not show a significant difference in opioid consumption or pain scores in adolescents undergoing idiopathic scoliosis surgery." | 9.19 | Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial. ( Campbell, F; Mayell, A; Peliowski, A; Srinivasan, I, 2014) |
"Adolescent patients undergoing idiopathic scoliosis surgery were randomized to receive a single preoperative dose of gabapentin 600 mg or placebo." | 5.19 | Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial. ( Campbell, F; Mayell, A; Peliowski, A; Srinivasan, I, 2014) |
"A single preoperative dose of gabapentin did not show a significant difference in opioid consumption or pain scores in adolescents undergoing idiopathic scoliosis surgery." | 5.19 | Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial. ( Campbell, F; Mayell, A; Peliowski, A; Srinivasan, I, 2014) |
"Gabapentin has opioid-sparing effects in adult surgical patients, but no reported studies have involved children and adolescents." | 2.75 | Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial. ( Berens, RJ; Czarnecki, ML; Hainsworth, KR; Lyon, RM; Nelson, TJ; Rusy, LM; Tassone, JC; Thometz, JG; Weisman, SJ, 2010) |
"Variation in postoperative pain management for children undergoing PSF for AIS likely impacts outcomes." | 1.46 | The Association Between Adjuvant Pain Medication Use and Outcomes Following Pediatric Spinal Fusion. ( Cohen, M; Erickson, M; Errico, T; McLeod, L; Rosenberg, RE; Trzcinski, S, 2017) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 3 (100.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Mayell, A | 1 |
Srinivasan, I | 1 |
Campbell, F | 1 |
Peliowski, A | 1 |
Rosenberg, RE | 1 |
Trzcinski, S | 1 |
Cohen, M | 1 |
Erickson, M | 1 |
Errico, T | 1 |
McLeod, L | 1 |
Rusy, LM | 1 |
Hainsworth, KR | 1 |
Nelson, TJ | 1 |
Czarnecki, ML | 1 |
Tassone, JC | 1 |
Thometz, JG | 1 |
Lyon, RM | 1 |
Berens, RJ | 1 |
Weisman, SJ | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Use of Gabapentin as Preanesthetic Medication in Oncologic Children Undergoing in Fast Procedures With Sevofluran[NCT03681574] | Phase 4 | 135 participants (Actual) | Interventional | 2017-07-01 | Completed | ||
Placebo Controlled, Randomized,Gabapentin as Adjuvant for Postoperative Pain in Pediatric Orthopedic Surgery[NCT03005483] | Phase 4 | 40 participants (Actual) | Interventional | 2014-01-31 | Completed | ||
Efficacy of Gabapentin as Adjuvant for Postoperative Pain in Pediatric Thoracic Surgery - a Randomized Quadruple Blind Study[NCT03393702] | Phase 4 | 104 participants (Actual) | Interventional | 2017-05-09 | Completed | ||
Perioperative Methadone Use to Decrease Opioid Requirement in Pediatric Spinal Fusion Patients[NCT02558010] | Phase 3 | 58 participants (Actual) | Interventional | 2016-02-01 | Completed | ||
Gabapentin Regimens and Their Effects on Opioid Consumption[NCT03334903] | Phase 4 | 77 participants (Actual) | Interventional | 2018-05-15 | Completed | ||
Pain Control in Pediatric Posterior Spine Fusion Patients: The Effect of Gabapentin on Post-operative Opioid Use and Patient Satisfaction[NCT01977937] | Phase 4 | 55 participants (Actual) | Interventional | 2013-11-30 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Total amount of opioids consumed during the first 72 hours after surgery. (NCT02558010)
Timeframe: 72 hours
Intervention | mg/kg (Median) |
---|---|
Methadone Group | 0.267 |
Control Group | 0.340 |
Surgical site pain. Scale 0-10, with 0 best and 10 worst (NCT03334903)
Timeframe: 2-3 months after surgery (at 2nd postoperative appointment)
Intervention | score on 10-point scale (Mean) |
---|---|
Standard of Care | 2.26 |
Postoperative Gabapentin Regimen | 2.46 |
Surgical site pain. Scale 0-10, with 0 best and 10 worst. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).
Intervention | score on a 10-point scale (Mean) |
---|---|
Standard of Care | 3.84 |
Postoperative Gabapentin Regimen | 3.54 |
Sleep quality. Scale 0-10 with 0 worst and 10 best. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).
Intervention | score on a 10-point scale (Mean) |
---|---|
Standard of Care | 5.73 |
Postoperative Gabapentin Regimen | 6.38 |
Nausea. Scale 0-10, with 0 best and 10 worst. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).
Intervention | score on a 10-point scale (Mean) |
---|---|
Standard of Care | 0.36 |
Postoperative Gabapentin Regimen | 0.17 |
Satisfaction. Scale 0-10 with 0 worst and 10 best. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).
Intervention | score on a 10-point scale (Mean) |
---|---|
Standard of Care | 7.83 |
Postoperative Gabapentin Regimen | 8.48 |
Number of days until patients are finished consuming opioid medications after discharge. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).
Intervention | days (Mean) |
---|---|
Standard of Care | 14.8 |
Postoperative Gabapentin Regimen | 18.7 |
Mean opioid consumption, measured in mg of morphine equivalents. (NCT03334903)
Timeframe: 2-3 months following surgery (total amount measured at second postoperative appointment; means assessed afterwards).
Intervention | morphine equivalents (Mean) |
---|---|
Standard of Care | 287.0 |
Postoperative Gabapentin Regimen | 281.1 |
"Patients will rate their pain using the Visual Analog Pain Scale (VAS). The VAS is a 10 cm line with anchors of no pain and worst pain imaginable. Patients rate their pain by marking on the 10 cm line where they feel their pain is at the time. The mark is then measured according to where it is along the 10 cm line and reported (range is 0.0 at the no pain end on the left up to 10.0 at the worst pain imaginable on the right). Lower pain scores on the VAS scale are considered a better outcome. The numbers seen in the outcome measure data table below represent an average of the total postoperative VAS scores recorded for each patient from each arm for the duration of their hospital stay." (NCT01977937)
Timeframe: five days
Intervention | pain score on a scale (Mean) |
---|---|
Gabapentin | 2.46 |
Simple Syrup | 3.46 |
Total the amount of Hydromorphone and Oxycodone used in milligrams per kilogram in each patient post-operatively, convert this amount to morphine equivalents, and determine if there is a significant difference between the Gabapentin versus Placebo group. (NCT01977937)
Timeframe: Five Days
Intervention | morphine equivalents mg per kg (Mean) |
---|---|
Gabapentin | 3.58 |
Simple Syrup | 5.33 |
2 trials available for gamma-aminobutyric acid and Scoliosis
Article | Year |
---|---|
Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial.
Topics: Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Cyclohexanecarbox | 2014 |
Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial.
Topics: Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Cyclohexanecarbox | 2014 |
Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial.
Topics: Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Cyclohexanecarbox | 2014 |
Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial.
Topics: Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Cyclohexanecarbox | 2014 |
Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial.
Topics: Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Cyclohexanecarbox | 2014 |
Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial.
Topics: Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Cyclohexanecarbox | 2014 |
Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial.
Topics: Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Cyclohexanecarbox | 2014 |
Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial.
Topics: Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Cyclohexanecarbox | 2014 |
Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial.
Topics: Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Cyclohexanecarbox | 2014 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch | 2010 |
1 other study available for gamma-aminobutyric acid and Scoliosis
Article | Year |
---|---|
The Association Between Adjuvant Pain Medication Use and Outcomes Following Pediatric Spinal Fusion.
Topics: Adolescent; Analgesics, Opioid; Child; Female; gamma-Aminobutyric Acid; Hospitals, Pediatric; Humans | 2017 |