Page last updated: 2024-10-16

gamma-aminobutyric acid and Scoliosis

gamma-aminobutyric acid has been researched along with Scoliosis in 3 studies

gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.

Scoliosis: An appreciable lateral deviation in the normally straight vertical line of the spine. (Dorland, 27th ed)

Research Excerpts

ExcerptRelevanceReference
"Adolescent patients undergoing idiopathic scoliosis surgery were randomized to receive a single preoperative dose of gabapentin 600 mg or placebo."9.19Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial. ( Campbell, F; Mayell, A; Peliowski, A; Srinivasan, I, 2014)
"A single preoperative dose of gabapentin did not show a significant difference in opioid consumption or pain scores in adolescents undergoing idiopathic scoliosis surgery."9.19Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial. ( Campbell, F; Mayell, A; Peliowski, A; Srinivasan, I, 2014)
"Adolescent patients undergoing idiopathic scoliosis surgery were randomized to receive a single preoperative dose of gabapentin 600 mg or placebo."5.19Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial. ( Campbell, F; Mayell, A; Peliowski, A; Srinivasan, I, 2014)
"A single preoperative dose of gabapentin did not show a significant difference in opioid consumption or pain scores in adolescents undergoing idiopathic scoliosis surgery."5.19Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial. ( Campbell, F; Mayell, A; Peliowski, A; Srinivasan, I, 2014)
"Gabapentin has opioid-sparing effects in adult surgical patients, but no reported studies have involved children and adolescents."2.75Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial. ( Berens, RJ; Czarnecki, ML; Hainsworth, KR; Lyon, RM; Nelson, TJ; Rusy, LM; Tassone, JC; Thometz, JG; Weisman, SJ, 2010)
"Variation in postoperative pain management for children undergoing PSF for AIS likely impacts outcomes."1.46The Association Between Adjuvant Pain Medication Use and Outcomes Following Pediatric Spinal Fusion. ( Cohen, M; Erickson, M; Errico, T; McLeod, L; Rosenberg, RE; Trzcinski, S, 2017)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mayell, A1
Srinivasan, I1
Campbell, F1
Peliowski, A1
Rosenberg, RE1
Trzcinski, S1
Cohen, M1
Erickson, M1
Errico, T1
McLeod, L1
Rusy, LM1
Hainsworth, KR1
Nelson, TJ1
Czarnecki, ML1
Tassone, JC1
Thometz, JG1
Lyon, RM1
Berens, RJ1
Weisman, SJ1

Clinical Trials (6)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Use of Gabapentin as Preanesthetic Medication in Oncologic Children Undergoing in Fast Procedures With Sevofluran[NCT03681574]Phase 4135 participants (Actual)Interventional2017-07-01Completed
Placebo Controlled, Randomized,Gabapentin as Adjuvant for Postoperative Pain in Pediatric Orthopedic Surgery[NCT03005483]Phase 440 participants (Actual)Interventional2014-01-31Completed
Efficacy of Gabapentin as Adjuvant for Postoperative Pain in Pediatric Thoracic Surgery - a Randomized Quadruple Blind Study[NCT03393702]Phase 4104 participants (Actual)Interventional2017-05-09Completed
Perioperative Methadone Use to Decrease Opioid Requirement in Pediatric Spinal Fusion Patients[NCT02558010]Phase 358 participants (Actual)Interventional2016-02-01Completed
Gabapentin Regimens and Their Effects on Opioid Consumption[NCT03334903]Phase 477 participants (Actual)Interventional2018-05-15Completed
Pain Control in Pediatric Posterior Spine Fusion Patients: The Effect of Gabapentin on Post-operative Opioid Use and Patient Satisfaction[NCT01977937]Phase 455 participants (Actual)Interventional2013-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Post-operative Opioid Consumption (mg/kg)

Total amount of opioids consumed during the first 72 hours after surgery. (NCT02558010)
Timeframe: 72 hours

Interventionmg/kg (Median)
Methadone Group0.267
Control Group0.340

"VAS Score 1: How Much Pain do You Feel in Your Operative Site When Resting?"

Surgical site pain. Scale 0-10, with 0 best and 10 worst (NCT03334903)
Timeframe: 2-3 months after surgery (at 2nd postoperative appointment)

Interventionscore on 10-point scale (Mean)
Standard of Care2.26
Postoperative Gabapentin Regimen2.46

"VAS Score 2: How Much Pain do You Feel in Your Operative Site When Moving?"

Surgical site pain. Scale 0-10, with 0 best and 10 worst. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

Interventionscore on a 10-point scale (Mean)
Standard of Care3.84
Postoperative Gabapentin Regimen3.54

"VAS Score 3: How Well Are You Sleeping?"

Sleep quality. Scale 0-10 with 0 worst and 10 best. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

Interventionscore on a 10-point scale (Mean)
Standard of Care5.73
Postoperative Gabapentin Regimen6.38

"VAS Score 4: How Bad is Your Nausea?"

Nausea. Scale 0-10, with 0 best and 10 worst. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

Interventionscore on a 10-point scale (Mean)
Standard of Care0.36
Postoperative Gabapentin Regimen0.17

"VAS Score 5: How Satisfied Are You With Your Pain Management?"

Satisfaction. Scale 0-10 with 0 worst and 10 best. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

Interventionscore on a 10-point scale (Mean)
Standard of Care7.83
Postoperative Gabapentin Regimen8.48

Days Taking Opioids

Number of days until patients are finished consuming opioid medications after discharge. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

Interventiondays (Mean)
Standard of Care14.8
Postoperative Gabapentin Regimen18.7

Opioid Consumption

Mean opioid consumption, measured in mg of morphine equivalents. (NCT03334903)
Timeframe: 2-3 months following surgery (total amount measured at second postoperative appointment; means assessed afterwards).

Interventionmorphine equivalents (Mean)
Standard of Care287.0
Postoperative Gabapentin Regimen281.1

Difference in Pain Control When Adding Gabapentin to a Multimodal Pain Management Protocol in Pediatric Post-operative Posterior Spinal Fusion Patients.

"Patients will rate their pain using the Visual Analog Pain Scale (VAS). The VAS is a 10 cm line with anchors of no pain and worst pain imaginable. Patients rate their pain by marking on the 10 cm line where they feel their pain is at the time. The mark is then measured according to where it is along the 10 cm line and reported (range is 0.0 at the no pain end on the left up to 10.0 at the worst pain imaginable on the right). Lower pain scores on the VAS scale are considered a better outcome. The numbers seen in the outcome measure data table below represent an average of the total postoperative VAS scores recorded for each patient from each arm for the duration of their hospital stay." (NCT01977937)
Timeframe: five days

Interventionpain score on a scale (Mean)
Gabapentin2.46
Simple Syrup3.46

Opiate Usage in the Gabapentin Group Versus Control.

Total the amount of Hydromorphone and Oxycodone used in milligrams per kilogram in each patient post-operatively, convert this amount to morphine equivalents, and determine if there is a significant difference between the Gabapentin versus Placebo group. (NCT01977937)
Timeframe: Five Days

Interventionmorphine equivalents mg per kg (Mean)
Gabapentin3.58
Simple Syrup5.33

Trials

2 trials available for gamma-aminobutyric acid and Scoliosis

ArticleYear
Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial.
    Paediatric anaesthesia, 2014, Volume: 24, Issue:12

    Topics: Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Cyclohexanecarbox

2014
Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial.
    Paediatric anaesthesia, 2014, Volume: 24, Issue:12

    Topics: Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Cyclohexanecarbox

2014
Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial.
    Paediatric anaesthesia, 2014, Volume: 24, Issue:12

    Topics: Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Cyclohexanecarbox

2014
Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial.
    Paediatric anaesthesia, 2014, Volume: 24, Issue:12

    Topics: Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Cyclohexanecarbox

2014
Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial.
    Paediatric anaesthesia, 2014, Volume: 24, Issue:12

    Topics: Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Cyclohexanecarbox

2014
Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial.
    Paediatric anaesthesia, 2014, Volume: 24, Issue:12

    Topics: Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Cyclohexanecarbox

2014
Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial.
    Paediatric anaesthesia, 2014, Volume: 24, Issue:12

    Topics: Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Cyclohexanecarbox

2014
Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial.
    Paediatric anaesthesia, 2014, Volume: 24, Issue:12

    Topics: Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Cyclohexanecarbox

2014
Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial.
    Paediatric anaesthesia, 2014, Volume: 24, Issue:12

    Topics: Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Cyclohexanecarbox

2014
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
    Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5

    Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch

2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
    Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5

    Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch

2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
    Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5

    Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch

2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
    Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5

    Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch

2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
    Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5

    Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch

2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
    Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5

    Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch

2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
    Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5

    Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch

2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
    Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5

    Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch

2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
    Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5

    Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch

2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
    Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5

    Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch

2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
    Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5

    Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch

2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
    Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5

    Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch

2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
    Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5

    Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch

2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
    Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5

    Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch

2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
    Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5

    Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch

2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
    Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5

    Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch

2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
    Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5

    Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch

2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
    Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5

    Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch

2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
    Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5

    Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch

2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
    Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5

    Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch

2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
    Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5

    Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch

2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
    Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5

    Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch

2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
    Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5

    Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch

2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
    Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5

    Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch

2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
    Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5

    Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch

2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
    Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5

    Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch

2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
    Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5

    Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch

2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
    Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5

    Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch

2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
    Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5

    Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch

2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
    Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5

    Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch

2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
    Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5

    Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch

2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
    Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5

    Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch

2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
    Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5

    Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch

2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
    Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5

    Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch

2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
    Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5

    Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch

2010
Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial.
    Anesthesia and analgesia, 2010, May-01, Volume: 110, Issue:5

    Topics: Acute Disease; Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Ch

2010

Other Studies

1 other study available for gamma-aminobutyric acid and Scoliosis

ArticleYear
The Association Between Adjuvant Pain Medication Use and Outcomes Following Pediatric Spinal Fusion.
    Spine, 2017, May-15, Volume: 42, Issue:10

    Topics: Adolescent; Analgesics, Opioid; Child; Female; gamma-Aminobutyric Acid; Hospitals, Pediatric; Humans

2017