gamma-aminobutyric acid has been researched along with Renal Insufficiency in 7 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
Renal Insufficiency: Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cefoselis is a widely used beta-lactam antibiotic, but occasionally induces seizures and convulsion in elder and renal failure patients." | 3.72 | Cefoselis, a beta-lactam antibiotic, easily penetrates the blood-brain barrier and causes seizure independently by glutamate release. ( Awaya, T; Chiba, K; Fujimaru, S; Hayase, N; Matsubara, K; Ohtaki, K; Shimizu, K; Shiono, H; Suno, M, 2004) |
| " Pregabalin pharmacokinetic parameters were evaluated by established noncompartmental methods." | 2.71 | Pharmacokinetics of pregabalin in subjects with various degrees of renal function. ( Alvey, CW; Bockbrader, HN; Cook, JA; Posvar, EL; Randinitis, EJ; Sedman, AJ, 2003) |
| " Results form the basis of recommended pregabalin dosing regimens in patients with decreased renal function." | 2.71 | Pharmacokinetics of pregabalin in subjects with various degrees of renal function. ( Alvey, CW; Bockbrader, HN; Cook, JA; Posvar, EL; Randinitis, EJ; Sedman, AJ, 2003) |
| "Gabapentin is an antiepileptic agent that is indicated for use as adjunctive therapy for partial seizures." | 1.30 | A case of sustained massive gabapentin overdose without serious side effects. ( Radtke, RA; St Clair, EW; Verma, A, 1999) |
| " It has a relatively benign side effect profile, but little data exists on massive overdoses with this agent." | 1.30 | A case of sustained massive gabapentin overdose without serious side effects. ( Radtke, RA; St Clair, EW; Verma, A, 1999) |
| "Gabapentin CL/F and CLR were linearly correlated with creatinine clearance." | 1.29 | Pharmacokinetics of gabapentin in subjects with various degrees of renal function. ( Blum, RA; Bockbrader, H; Busch, JA; Comstock, TJ; Keller, E; Reece, PA; Reetze, P; Schultz, RW; Sica, DA; Tuerck, D, 1994) |
| " Apparent oral plasma clearance (CL/F) and renal clearance (CLR) of gabapentin decreased and maximum plasma concentration, time to reach maximum concentration, and half-life values increased as renal function diminished." | 1.29 | Pharmacokinetics of gabapentin in subjects with various degrees of renal function. ( Blum, RA; Bockbrader, H; Busch, JA; Comstock, TJ; Keller, E; Reece, PA; Reetze, P; Schultz, RW; Sica, DA; Tuerck, D, 1994) |
| " Based on pharmacokinetic considerations, it appears that the dosing regimen of gabapentin in subjects with renal impairment may be adjusted on the basis of creatinine clearance." | 1.29 | Pharmacokinetics of gabapentin in subjects with various degrees of renal function. ( Blum, RA; Bockbrader, H; Busch, JA; Comstock, TJ; Keller, E; Reece, PA; Reetze, P; Schultz, RW; Sica, DA; Tuerck, D, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (57.14) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hosseini-Zare, MS | 1 |
| Dashti-Khavidaki, S | 1 |
| Mahdavi-Mazdeh, M | 1 |
| Ahmadi, F | 1 |
| Akrami, S | 1 |
| Randinitis, EJ | 1 |
| Posvar, EL | 1 |
| Alvey, CW | 1 |
| Sedman, AJ | 1 |
| Cook, JA | 1 |
| Bockbrader, HN | 1 |
| Ohtaki, K | 1 |
| Matsubara, K | 1 |
| Fujimaru, S | 1 |
| Shimizu, K | 1 |
| Awaya, T | 1 |
| Suno, M | 1 |
| Chiba, K | 1 |
| Hayase, N | 1 |
| Shiono, H | 1 |
| Blum, RA | 1 |
| Comstock, TJ | 1 |
| Sica, DA | 1 |
| Schultz, RW | 1 |
| Keller, E | 1 |
| Reetze, P | 1 |
| Bockbrader, H | 1 |
| Tuerck, D | 1 |
| Busch, JA | 1 |
| Reece, PA | 1 |
| Tammara, V | 1 |
| Mahmood, I | 1 |
| Yu, DK | 1 |
| Hileman, GA | 1 |
| Ifergane, G | 1 |
| Masalha, R | 1 |
| Zigulinski, R | 1 |
| Merkin, L | 1 |
| Wirguin, I | 1 |
| Herishanu, YO | 1 |
| Verma, A | 1 |
| St Clair, EW | 1 |
| Radtke, RA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Confirmatory Study of Efficacy and Safety of the Pregabalin/Tramadol Combination Versus Pregabalin in the Management of Acute Pain of Neuropathic Origin.[NCT05324059] | Phase 3 | 110 participants (Actual) | Interventional | 2022-07-11 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for gamma-aminobutyric acid and Renal Insufficiency
| Article | Year |
|---|---|
Pharmacokinetics of pregabalin in subjects with various degrees of renal function.
Topics: Administration, Oral; Adolescent; Adult; Aged; Anticonvulsants; Area Under Curve; Creatinine; Dose-R | 2003 |
A limited sampling method for the estimation of vigabatrin maximum plasma concentration and area under the curve.
Topics: Anticonvulsants; Area Under Curve; Cross-Over Studies; gamma-Aminobutyric Acid; Humans; Renal Insuff | 1997 |
5 other studies available for gamma-aminobutyric acid and Renal Insufficiency
| Article | Year |
|---|---|
Peripheral neuropathy response to erythropoietin in type 2 diabetic patients with mild to moderate renal failure.
Topics: Aged; Aged, 80 and over; Amines; Cyclohexanecarboxylic Acids; Diabetes Mellitus, Type 2; Diabetic Ne | 2012 |
Cefoselis, a beta-lactam antibiotic, easily penetrates the blood-brain barrier and causes seizure independently by glutamate release.
Topics: Animals; Anti-Bacterial Agents; Blood-Brain Barrier; Brain; Cefazolin; Ceftizoxime; Chromatography, | 2004 |
Pharmacokinetics of gabapentin in subjects with various degrees of renal function.
Topics: Acetates; Administration, Oral; Adolescent; Adult; Aged; Amines; Creatinine; Cyclohexanecarboxylic A | 1994 |
Acute encephalopathy associated with vigabatrin monotherapy in patients with mild renal failure.
Topics: Acute Disease; Adult; Aged; Anticonvulsants; Electroencephalography; Encephalitis; Epilepsy, General | 1998 |
A case of sustained massive gabapentin overdose without serious side effects.
Topics: Acetates; Adult; Amines; Anticonvulsants; Cognition; Cyclohexanecarboxylic Acids; Drug Overdose; Epi | 1999 |