gamma-aminobutyric acid has been researched along with Pruritus in 72 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
Pruritus: An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pregabalin is an effective alternative for treatment of uraemic pruritus." | 9.20 | Comparison of pregabalin with ondansetron in treatment of uraemic pruritus in dialysis patients: a prospective, randomized, double-blind study. ( Jiao, S; Meng, J; Ren, W; Xiao, Y; Yue, J; Zhao, T, 2015) |
| "Gabapentin relieved itching in 47 patients (66%)." | 9.16 | Uraemic pruritus: relief of itching by gabapentin and pregabalin. ( Baharani, J; Dasgupta, I; Rayner, H; Smith, S; Suresh, V, 2012) |
| "Gabapentin or pregabalin relieved itching in 85% of 71 consecutively treated CKD patients." | 9.16 | Uraemic pruritus: relief of itching by gabapentin and pregabalin. ( Baharani, J; Dasgupta, I; Rayner, H; Smith, S; Suresh, V, 2012) |
| "To compare the efficacy and side effects of gabapentin and desloratadine in patients with dialysis pruritus." | 9.16 | Uremic pruritus in hemodialysis patients: treatment with desloratidine versus gabapentin. ( Barrón, B; Lauxmann, JE; Marquez, D; Martinatto, C; Novoa, PA; Orías, M; Peixoto, AJ; Ramonda, C; Romero, CA; Vukelic, VL, 2012) |
| "Desloratadine provides significant relief of uremic pruritus compared with no therapy." | 9.16 | Uremic pruritus in hemodialysis patients: treatment with desloratidine versus gabapentin. ( Barrón, B; Lauxmann, JE; Marquez, D; Martinatto, C; Novoa, PA; Orías, M; Peixoto, AJ; Ramonda, C; Romero, CA; Vukelic, VL, 2012) |
| "Gabapentin is an effective agent in treating uremic pruritus." | 9.14 | Gabapentin and uremic pruritus in hemodialysis patients. ( Eskandari, D; Ganji, MR; Khashayar, P; Meysamie, AP; Razeghi, E; Togha, M, 2009) |
| "The incidence of pruritus was significantly more frequent in the placebo group compared with the gabapentin group (77." | 9.13 | Preoperative gabapentin prevents intrathecal morphine-induced pruritus after orthopedic surgery. ( Chang, FL; Ho, ST; Lee, CH; Sheen, MJ; Tsung, YC, 2008) |
| "Preoperative gabapentin prevents pruritus induced by intrathecal morphine in patients undergoing lower limb surgery with spinal anesthesia." | 9.13 | Preoperative gabapentin prevents intrathecal morphine-induced pruritus after orthopedic surgery. ( Chang, FL; Ho, ST; Lee, CH; Sheen, MJ; Tsung, YC, 2008) |
| "Pruritus is the most common side effect of intrathecal morphine." | 9.13 | Preoperative gabapentin prevents intrathecal morphine-induced pruritus after orthopedic surgery. ( Chang, FL; Ho, ST; Lee, CH; Sheen, MJ; Tsung, YC, 2008) |
| "Pruritus is defined as the second order of nociception, the first being pain; thus, there is a rationale to study gabapentin, a drug that increases the threshold to experience nociception." | 9.12 | Gabapentin in patients with the pruritus of cholestasis: a double-blind, randomized, placebo-controlled trial. ( Bergasa, NV; Engler, D; Ginsburg, IH; McGee, M, 2006) |
| "Our study shows that gabapentin is safe and effective for treating uraemic pruritus in haemodialysis patients." | 9.11 | Gabapentin therapy for pruritus in haemodialysis patients: a randomized, placebo-controlled, double-blind trial. ( Celiker, H; Gunal, AI; Gunal, SY; Kirciman, E; Ozalp, G; Yoldas, TK, 2004) |
| "Gabapentin has an antipruritus effect, which its efficacy in reducing pruritus induced by intrathecal morphine has not been well documented." | 8.88 | Single dose of gabapentin for prophylaxis intrathecal morphine-induced pruritus in orthopedic surgery: a randomized controlled trial. ( Chiravanich, W; Kovitwanawong, N; Oofuvong, M, 2012) |
| "The overall incidence of pruritus was not significantly different between the two groups while the incidence and severity of pruritus was significantly decreased in the gabapentin group at four hours after intrathecal morphine injection (18 of 84 subjects, 21." | 8.88 | Single dose of gabapentin for prophylaxis intrathecal morphine-induced pruritus in orthopedic surgery: a randomized controlled trial. ( Chiravanich, W; Kovitwanawong, N; Oofuvong, M, 2012) |
| "Preoperative gabapentin 600 mg did not significantly reduce the postoperative intrathecal morphine-induced pruritus." | 8.88 | Single dose of gabapentin for prophylaxis intrathecal morphine-induced pruritus in orthopedic surgery: a randomized controlled trial. ( Chiravanich, W; Kovitwanawong, N; Oofuvong, M, 2012) |
| "To determine the safety and effectiveness of gabapentin for pruritus or RLS in conservatively managed patients (n = 34) with CKD and ESKD." | 7.81 | Efficacy and safety of gabapentin for uremic pruritus and restless legs syndrome in conservatively managed patients with chronic kidney disease. ( Brennan, F; Brown, MA; Cheikh Hassan, HI; Collett, G; Josland, EA, 2015) |
| "Gabapentin is a viable treatment for conservatively managed CKD and ESKD patients with pruritus and/or RLS, but side effects are common." | 7.81 | Efficacy and safety of gabapentin for uremic pruritus and restless legs syndrome in conservatively managed patients with chronic kidney disease. ( Brennan, F; Brown, MA; Cheikh Hassan, HI; Collett, G; Josland, EA, 2015) |
| "Itching was induced via neonatal capsaicin treatment in Sprague-Dawley rats (itching rats), and scratching behavior of the control, itching, and gabapentin (GBP)-treated itching rats was compared." | 7.81 | Investigation of the pruritus-induced functional activity in the rat brain using manganese-enhanced MRI. ( Jeong, KY; Kang, JH, 2015) |
| "To provide clear information on the activation regions of itching, we investigated the functional activity of cerebral regions in the pruritus-induced rat model using manganese-enhanced magnetic resonance imaging (MEMRI)." | 7.81 | Investigation of the pruritus-induced functional activity in the rat brain using manganese-enhanced MRI. ( Jeong, KY; Kang, JH, 2015) |
| "Compared with that before treatment, the itching degree of patients with light, moderate, and severe itching in placebo group was not relieved after treatment; the itching degree of patients with moderate or severe itching in cetirizine group was alleviated after treatment, but not in patients with light itching; itching degree of all patients in gabapentin group was significantly relieved after treatment." | 7.81 | [Clinical effects of gabapentin on the treatment of pruritus of scar resulting from deep partial-thickness burn]. ( Bing, Z; Qiang, W; Wei, L; Zheng, L, 2015) |
| "For patients with deep partial-thickness burn, gabapentin can effectively alleviate scar itching after wound healing with safety." | 7.81 | [Clinical effects of gabapentin on the treatment of pruritus of scar resulting from deep partial-thickness burn]. ( Bing, Z; Qiang, W; Wei, L; Zheng, L, 2015) |
| "To study the clinical effects of gabapentin on the treatment of pruritus of scar resulting from deep partial-thickness burn." | 7.81 | [Clinical effects of gabapentin on the treatment of pruritus of scar resulting from deep partial-thickness burn]. ( Bing, Z; Qiang, W; Wei, L; Zheng, L, 2015) |
| " Pregabalin was administered to treat the pruritus, and a considerable improvement was observed." | 7.79 | Successful treatment of chronic intractable itching using oral pregabalin in a patient with diabetes and systemic prurigo nodularis: a case report of an iliopsoas muscle abscess. ( Goto, A; Goto, M; Hachiya, R; Ihana, N; Imai, K; Inoue, K; Kajio, H; Kishimoto, M; Noda, M; Noto, H; Ono, K; Tsujimoto, T; Yamamoto-Honda, R, 2013) |
| "We evaluated the effect of pregabalin in the treatment of uraemic pruritus not due to secondary hyperparathyroidism." | 7.76 | The use of pregabalin in the treatment of uraemic pruritus in haemodialysis patients. ( Alivanis, P; Aperis, G; Arvanitis, A; Paliouras, C; Zervos, A, 2010) |
| "To evaluate the efficacy of gabapentin for the treatment of uremic pruritus (UP)." | 7.74 | Role of gabapentin in the treatment of uremic pruritus. ( Gommer, J; Scates, AC; Vila, T, 2008) |
| "Literature retrieval was accessed through MEDLINE (1950-March week 3, 2008; In-Process & Other Non-Indexed Citations, April 1, 2008) and International Pharmaceutical Abstracts (1970-March 2008) using the terms gabapentin, pruritus, itch, urem$ (truncated), dialysis, and kidney disease." | 7.74 | Role of gabapentin in the treatment of uremic pruritus. ( Gommer, J; Scates, AC; Vila, T, 2008) |
| "We describe the use of gabapentin for the treatment of itching in wound healing in 35 children." | 7.72 | Gabapentin for the treatment of itching produced by burns and wound healing in children: a pilot study. ( Mendham, JE, 2004) |
| "Gabapentin is a promising and a well-tolerated treatment option for patients with UP." | 6.82 | Gabapentin: A promising therapy for uremic pruritus in hemodialysis patients: A randomized-controlled trial and review of literature. ( Abdelkhalik, Z; Alkot, R; Eldesouky, F; Farag, F; Nofal, A; Nofal, E, 2016) |
| "To evaluate efficacy, appropriate dosing regimen and safety of gabapentin on UP in hemodialysis (HD) patients." | 6.82 | Gabapentin: A promising therapy for uremic pruritus in hemodialysis patients: A randomized-controlled trial and review of literature. ( Abdelkhalik, Z; Alkot, R; Eldesouky, F; Farag, F; Nofal, A; Nofal, E, 2016) |
| "Ondansetron has negligible effect on uremic pruritus and is expensive." | 6.80 | Comparison of pregabalin with ondansetron in treatment of uraemic pruritus in dialysis patients: a prospective, randomized, double-blind study. ( Jiao, S; Meng, J; Ren, W; Xiao, Y; Yue, J; Zhao, T, 2015) |
| "Pruritus is common among patients with end-stage renal disease undergoing dialysis, and the pathogenesis can be explained by several mechanisms." | 6.80 | Comparison of pregabalin with ondansetron in treatment of uraemic pruritus in dialysis patients: a prospective, randomized, double-blind study. ( Jiao, S; Meng, J; Ren, W; Xiao, Y; Yue, J; Zhao, T, 2015) |
| "The average pretreatment pruritus score was 9." | 6.78 | Use of pregabalin in the management of chronic uremic pruritus. ( Grenader, T; Lifschitz, M; Shavit, L; Slotki, I, 2013) |
| " Drug dosage was determined by initial VAS (visual analog scale) scores." | 6.78 | A four arm, double blind, randomized and placebo controlled study of pregabalin in the management of post-burn pruritus. ( Ahuja, RB; Gupta, GK, 2013) |
| "gabapentin has marginal efficacy." | 6.77 | Uremic pruritus in hemodialysis patients: treatment with desloratidine versus gabapentin. ( Barrón, B; Lauxmann, JE; Marquez, D; Martinatto, C; Novoa, PA; Orías, M; Peixoto, AJ; Ramonda, C; Romero, CA; Vukelic, VL, 2012) |
| "Desloratadine was well tolerated." | 6.77 | Uremic pruritus in hemodialysis patients: treatment with desloratidine versus gabapentin. ( Barrón, B; Lauxmann, JE; Marquez, D; Martinatto, C; Novoa, PA; Orías, M; Peixoto, AJ; Ramonda, C; Romero, CA; Vukelic, VL, 2012) |
| "Uremic pruritus is common among dialysis patients." | 6.77 | Uremic pruritus in hemodialysis patients: treatment with desloratidine versus gabapentin. ( Barrón, B; Lauxmann, JE; Marquez, D; Martinatto, C; Novoa, PA; Orías, M; Peixoto, AJ; Ramonda, C; Romero, CA; Vukelic, VL, 2012) |
| "Pruritus is common in dialysis patients." | 6.77 | Pregabalin versus gabapentin in the treatment of neuropathic pruritus in maintenance haemodialysis patients: a prospective, crossover study. ( Atalay, H; Biyik, Z; Covic, A; Gaipov, A; Goldsmith, D; Guney, F; Kanbay, M; Solak, Y; Turk, S, 2012) |
| "Gabapentin and pregabalin improved both neuropathic pain and pruritus significantly." | 6.77 | Pregabalin versus gabapentin in the treatment of neuropathic pruritus in maintenance haemodialysis patients: a prospective, crossover study. ( Atalay, H; Biyik, Z; Covic, A; Gaipov, A; Goldsmith, D; Guney, F; Kanbay, M; Solak, Y; Turk, S, 2012) |
| "Treatment of neuropathic pain with either pregabalin or gabapentin effectively ameliorates uraemic itch." | 6.77 | Pregabalin versus gabapentin in the treatment of neuropathic pruritus in maintenance haemodialysis patients: a prospective, crossover study. ( Atalay, H; Biyik, Z; Covic, A; Gaipov, A; Goldsmith, D; Guney, F; Kanbay, M; Solak, Y; Turk, S, 2012) |
| "Gabapentin is an antiepileptic drug which has been successfully used to manage neuropathic pain, and is reporting to be successful in management of all forms of itch." | 6.76 | A comparative analysis of cetirizine, gabapentin and their combination in the relief of post-burn pruritus. ( Ahuja, RB; Gupta, G; Gupta, R; Shrivastava, P, 2011) |
| "Post-burn pruritis is a very distressing symptom having a reported incidence between 80 and 100%." | 6.76 | A comparative analysis of cetirizine, gabapentin and their combination in the relief of post-burn pruritus. ( Ahuja, RB; Gupta, G; Gupta, R; Shrivastava, P, 2011) |
| "Gabapentin is an effective agent in treating uremic pruritus." | 6.74 | Gabapentin and uremic pruritus in hemodialysis patients. ( Eskandari, D; Ganji, MR; Khashayar, P; Meysamie, AP; Razeghi, E; Togha, M, 2009) |
| "Pruritus is a common and bothersome problem in 30-50% of hemodialysis patients." | 6.74 | Gabapentin and uremic pruritus in hemodialysis patients. ( Eskandari, D; Ganji, MR; Khashayar, P; Meysamie, AP; Razeghi, E; Togha, M, 2009) |
| "Gabapentin is an effective drug in the management of neuropathic pain." | 6.73 | Gabapentin: a promising drug for the treatment of uremic pruritus. ( Harandi, AA; Khanbabapour, S; Mohseni, M; Naini, AE; Seirafiyan, S; Shahidi, S, 2007) |
| "Despite advances made in treatment, uremic pruritus remains a common and distressing symptom in patients on hemodialysis (HD)." | 6.73 | Gabapentin: a promising drug for the treatment of uremic pruritus. ( Harandi, AA; Khanbabapour, S; Mohseni, M; Naini, AE; Seirafiyan, S; Shahidi, S, 2007) |
| "Gabapentin is an anticonvulsant and had been reported to be effective in some chronic pruritus conditions." | 6.73 | Preoperative gabapentin prevents intrathecal morphine-induced pruritus after orthopedic surgery. ( Chang, FL; Ho, ST; Lee, CH; Sheen, MJ; Tsung, YC, 2008) |
| "Pruritus is the most common side effect of intrathecal morphine." | 6.73 | Preoperative gabapentin prevents intrathecal morphine-induced pruritus after orthopedic surgery. ( Chang, FL; Ho, ST; Lee, CH; Sheen, MJ; Tsung, YC, 2008) |
| "Pruritus was evaluated at 3, 6, 9, 12, and 24 h after intrathecal morphine administration." | 6.73 | Preoperative gabapentin prevents intrathecal morphine-induced pruritus after orthopedic surgery. ( Chang, FL; Ho, ST; Lee, CH; Sheen, MJ; Tsung, YC, 2008) |
| "Gabapentin was associated with an increase in mean HSA, in contrast to the placebo, which was associated with a decrease." | 6.72 | Gabapentin in patients with the pruritus of cholestasis: a double-blind, randomized, placebo-controlled trial. ( Bergasa, NV; Engler, D; Ginsburg, IH; McGee, M, 2006) |
| "Pruritus is defined as the second order of nociception, the first being pain; thus, there is a rationale to study gabapentin, a drug that increases the threshold to experience nociception." | 6.72 | Gabapentin in patients with the pruritus of cholestasis: a double-blind, randomized, placebo-controlled trial. ( Bergasa, NV; Engler, D; Ginsburg, IH; McGee, M, 2006) |
| "Gabapentin is an anticonvulsant that alleviates neuropathic pain." | 6.71 | Gabapentin therapy for pruritus in haemodialysis patients: a randomized, placebo-controlled, double-blind trial. ( Celiker, H; Gunal, AI; Gunal, SY; Kirciman, E; Ozalp, G; Yoldas, TK, 2004) |
| "Gabapentin or placebo were administered thrice weekly, at the end of haemodialysis sessions." | 6.71 | Gabapentin therapy for pruritus in haemodialysis patients: a randomized, placebo-controlled, double-blind trial. ( Celiker, H; Gunal, AI; Gunal, SY; Kirciman, E; Ozalp, G; Yoldas, TK, 2004) |
| "Uraemic pruritus is a common and distressing symptom in patients on haemodialysis for chronic renal failure." | 6.71 | Gabapentin therapy for pruritus in haemodialysis patients: a randomized, placebo-controlled, double-blind trial. ( Celiker, H; Gunal, AI; Gunal, SY; Kirciman, E; Ozalp, G; Yoldas, TK, 2004) |
| "Chronic pruritus is a distressing symptom that is often refractory to treatment." | 6.53 | Gabapentin and pregabalin for the treatment of chronic pruritus. ( Kwatra, SG; Matsuda, KM; Schonfeld, AR; Sharma, D, 2016) |
| "Gabapentin has an antipruritus effect, which its efficacy in reducing pruritus induced by intrathecal morphine has not been well documented." | 6.48 | Single dose of gabapentin for prophylaxis intrathecal morphine-induced pruritus in orthopedic surgery: a randomized controlled trial. ( Chiravanich, W; Kovitwanawong, N; Oofuvong, M, 2012) |
| "The pruritus was evaluated at 1, 2, 3, 4, 6, 9, 12 and 24 hours after intrathecal morphine administration." | 6.48 | Single dose of gabapentin for prophylaxis intrathecal morphine-induced pruritus in orthopedic surgery: a randomized controlled trial. ( Chiravanich, W; Kovitwanawong, N; Oofuvong, M, 2012) |
| "Gabapentin is a viable treatment for conservatively managed CKD and ESKD patients with pruritus and/or RLS, but side effects are common." | 5.42 | Efficacy and safety of gabapentin for uremic pruritus and restless legs syndrome in conservatively managed patients with chronic kidney disease. ( Brennan, F; Brown, MA; Cheikh Hassan, HI; Collett, G; Josland, EA, 2015) |
| " We compared dosing and side effects in 34 CKD/ESKD patients with similar patients receiving HD (n = 15)." | 5.42 | Efficacy and safety of gabapentin for uremic pruritus and restless legs syndrome in conservatively managed patients with chronic kidney disease. ( Brennan, F; Brown, MA; Cheikh Hassan, HI; Collett, G; Josland, EA, 2015) |
| "Pruritus and restless legs syndrome (RLS) frequently affect patients with chronic kidney disease (CKD) and end-stage kidney disease (ESKD), impacting the quality of life." | 5.42 | Efficacy and safety of gabapentin for uremic pruritus and restless legs syndrome in conservatively managed patients with chronic kidney disease. ( Brennan, F; Brown, MA; Cheikh Hassan, HI; Collett, G; Josland, EA, 2015) |
| "Itching was induced via neonatal capsaicin treatment in Sprague-Dawley rats (itching rats), and scratching behavior of the control, itching, and gabapentin (GBP)-treated itching rats was compared." | 5.42 | Investigation of the pruritus-induced functional activity in the rat brain using manganese-enhanced MRI. ( Jeong, KY; Kang, JH, 2015) |
| "Compared with that before treatment, the itching degree of patients with light, moderate, and severe itching in placebo group was not relieved after treatment; the itching degree of patients with moderate or severe itching in cetirizine group was alleviated after treatment, but not in patients with light itching; itching degree of all patients in gabapentin group was significantly relieved after treatment." | 5.42 | [Clinical effects of gabapentin on the treatment of pruritus of scar resulting from deep partial-thickness burn]. ( Bing, Z; Qiang, W; Wei, L; Zheng, L, 2015) |
| "Pregabalin was administered to treat the pruritus, and a considerable improvement was observed." | 5.39 | Successful treatment of chronic intractable itching using oral pregabalin in a patient with diabetes and systemic prurigo nodularis: a case report of an iliopsoas muscle abscess. ( Goto, A; Goto, M; Hachiya, R; Ihana, N; Imai, K; Inoue, K; Kajio, H; Kishimoto, M; Noda, M; Noto, H; Ono, K; Tsujimoto, T; Yamamoto-Honda, R, 2013) |
| "Brachioradial pruritus is a characteristic clinical condition with a deep intense itching, tingling or burning sensation localized to the dorsolateral part of the upper extremities." | 5.38 | [Brachioradial pruritus effectively treated with gabapentin]. ( Bygum, A; Uldall Pallesen, KA, 2012) |
| "Uraemic pruritus is a common and distressing symptom in patients undergoing haemodialysis." | 5.36 | The use of pregabalin in the treatment of uraemic pruritus in haemodialysis patients. ( Alivanis, P; Aperis, G; Arvanitis, A; Paliouras, C; Zervos, A, 2010) |
| "Gabapentin has been evaluated for the treatment of UP in 2 small, randomized, placebo-controlled studies, 1 pilot evaluation, and 1 index case." | 5.35 | Role of gabapentin in the treatment of uremic pruritus. ( Gommer, J; Scates, AC; Vila, T, 2008) |
| " Further well-designed trials are warranted to establish the most appropriate dosing regimen in patients on HD." | 5.35 | Role of gabapentin in the treatment of uremic pruritus. ( Gommer, J; Scates, AC; Vila, T, 2008) |
| "Within 24h of commencing treatment itching had improved significantly in all of the children." | 5.32 | Gabapentin for the treatment of itching produced by burns and wound healing in children: a pilot study. ( Mendham, JE, 2004) |
| "Pregabalin is an effective alternative for treatment of uraemic pruritus." | 5.20 | Comparison of pregabalin with ondansetron in treatment of uraemic pruritus in dialysis patients: a prospective, randomized, double-blind study. ( Jiao, S; Meng, J; Ren, W; Xiao, Y; Yue, J; Zhao, T, 2015) |
| "Gabapentin relieved itching in 47 patients (66%)." | 5.16 | Uraemic pruritus: relief of itching by gabapentin and pregabalin. ( Baharani, J; Dasgupta, I; Rayner, H; Smith, S; Suresh, V, 2012) |
| "Gabapentin or pregabalin relieved itching in 85% of 71 consecutively treated CKD patients." | 5.16 | Uraemic pruritus: relief of itching by gabapentin and pregabalin. ( Baharani, J; Dasgupta, I; Rayner, H; Smith, S; Suresh, V, 2012) |
| "To compare the efficacy and side effects of gabapentin and desloratadine in patients with dialysis pruritus." | 5.16 | Uremic pruritus in hemodialysis patients: treatment with desloratidine versus gabapentin. ( Barrón, B; Lauxmann, JE; Marquez, D; Martinatto, C; Novoa, PA; Orías, M; Peixoto, AJ; Ramonda, C; Romero, CA; Vukelic, VL, 2012) |
| "Desloratadine provides significant relief of uremic pruritus compared with no therapy." | 5.16 | Uremic pruritus in hemodialysis patients: treatment with desloratidine versus gabapentin. ( Barrón, B; Lauxmann, JE; Marquez, D; Martinatto, C; Novoa, PA; Orías, M; Peixoto, AJ; Ramonda, C; Romero, CA; Vukelic, VL, 2012) |
| "Gabapentin is an effective agent in treating uremic pruritus." | 5.14 | Gabapentin and uremic pruritus in hemodialysis patients. ( Eskandari, D; Ganji, MR; Khashayar, P; Meysamie, AP; Razeghi, E; Togha, M, 2009) |
| "The incidence of pruritus was significantly more frequent in the placebo group compared with the gabapentin group (77." | 5.13 | Preoperative gabapentin prevents intrathecal morphine-induced pruritus after orthopedic surgery. ( Chang, FL; Ho, ST; Lee, CH; Sheen, MJ; Tsung, YC, 2008) |
| "Preoperative gabapentin prevents pruritus induced by intrathecal morphine in patients undergoing lower limb surgery with spinal anesthesia." | 5.13 | Preoperative gabapentin prevents intrathecal morphine-induced pruritus after orthopedic surgery. ( Chang, FL; Ho, ST; Lee, CH; Sheen, MJ; Tsung, YC, 2008) |
| "Pruritus is the most common side effect of intrathecal morphine." | 5.13 | Preoperative gabapentin prevents intrathecal morphine-induced pruritus after orthopedic surgery. ( Chang, FL; Ho, ST; Lee, CH; Sheen, MJ; Tsung, YC, 2008) |
| "Pruritus is defined as the second order of nociception, the first being pain; thus, there is a rationale to study gabapentin, a drug that increases the threshold to experience nociception." | 5.12 | Gabapentin in patients with the pruritus of cholestasis: a double-blind, randomized, placebo-controlled trial. ( Bergasa, NV; Engler, D; Ginsburg, IH; McGee, M, 2006) |
| "Our study shows that gabapentin is safe and effective for treating uraemic pruritus in haemodialysis patients." | 5.11 | Gabapentin therapy for pruritus in haemodialysis patients: a randomized, placebo-controlled, double-blind trial. ( Celiker, H; Gunal, AI; Gunal, SY; Kirciman, E; Ozalp, G; Yoldas, TK, 2004) |
| "Despite the acknowledged importance of uremic pruritus to patients, with the exception of gabapentin, the current evidence for treatments is weak." | 4.95 | Treatment of Uremic Pruritus: A Systematic Review. ( Askin, N; Bohm, C; Komenda, P; Lerner, B; Rigatto, C; Shaw, J; Simonsen, E; Tangri, N, 2017) |
| " The complications of vomiting, nausea, dizziness and pruritus were also compiled to assess the safety of gabapentin and pregabalin." | 4.93 | The efficacy of preoperative administration of gabapentin/pregabalin in improving pain after total hip arthroplasty: a meta-analysis. ( Ding, W; Mao, Y; Wu, L, 2016) |
| "On the basis of the current meta-analysis, gabapentin or pregabalin can decrease the cumulative morphine consumption and decrease the occurrence of nausea; however, further trials are needed to assess the efficacy of pain control by gabapentin or pregabalin." | 4.93 | The efficacy of preoperative administration of gabapentin/pregabalin in improving pain after total hip arthroplasty: a meta-analysis. ( Ding, W; Mao, Y; Wu, L, 2016) |
| "Gabapentin has an antipruritus effect, which its efficacy in reducing pruritus induced by intrathecal morphine has not been well documented." | 4.88 | Single dose of gabapentin for prophylaxis intrathecal morphine-induced pruritus in orthopedic surgery: a randomized controlled trial. ( Chiravanich, W; Kovitwanawong, N; Oofuvong, M, 2012) |
| "The overall incidence of pruritus was not significantly different between the two groups while the incidence and severity of pruritus was significantly decreased in the gabapentin group at four hours after intrathecal morphine injection (18 of 84 subjects, 21." | 4.88 | Single dose of gabapentin for prophylaxis intrathecal morphine-induced pruritus in orthopedic surgery: a randomized controlled trial. ( Chiravanich, W; Kovitwanawong, N; Oofuvong, M, 2012) |
| "Preoperative gabapentin 600 mg did not significantly reduce the postoperative intrathecal morphine-induced pruritus." | 4.88 | Single dose of gabapentin for prophylaxis intrathecal morphine-induced pruritus in orthopedic surgery: a randomized controlled trial. ( Chiravanich, W; Kovitwanawong, N; Oofuvong, M, 2012) |
| "To determine the safety and effectiveness of gabapentin for pruritus or RLS in conservatively managed patients (n = 34) with CKD and ESKD." | 3.81 | Efficacy and safety of gabapentin for uremic pruritus and restless legs syndrome in conservatively managed patients with chronic kidney disease. ( Brennan, F; Brown, MA; Cheikh Hassan, HI; Collett, G; Josland, EA, 2015) |
| "Gabapentin is a viable treatment for conservatively managed CKD and ESKD patients with pruritus and/or RLS, but side effects are common." | 3.81 | Efficacy and safety of gabapentin for uremic pruritus and restless legs syndrome in conservatively managed patients with chronic kidney disease. ( Brennan, F; Brown, MA; Cheikh Hassan, HI; Collett, G; Josland, EA, 2015) |
| "Itching was induced via neonatal capsaicin treatment in Sprague-Dawley rats (itching rats), and scratching behavior of the control, itching, and gabapentin (GBP)-treated itching rats was compared." | 3.81 | Investigation of the pruritus-induced functional activity in the rat brain using manganese-enhanced MRI. ( Jeong, KY; Kang, JH, 2015) |
| "To provide clear information on the activation regions of itching, we investigated the functional activity of cerebral regions in the pruritus-induced rat model using manganese-enhanced magnetic resonance imaging (MEMRI)." | 3.81 | Investigation of the pruritus-induced functional activity in the rat brain using manganese-enhanced MRI. ( Jeong, KY; Kang, JH, 2015) |
| "Compared with that before treatment, the itching degree of patients with light, moderate, and severe itching in placebo group was not relieved after treatment; the itching degree of patients with moderate or severe itching in cetirizine group was alleviated after treatment, but not in patients with light itching; itching degree of all patients in gabapentin group was significantly relieved after treatment." | 3.81 | [Clinical effects of gabapentin on the treatment of pruritus of scar resulting from deep partial-thickness burn]. ( Bing, Z; Qiang, W; Wei, L; Zheng, L, 2015) |
| "For patients with deep partial-thickness burn, gabapentin can effectively alleviate scar itching after wound healing with safety." | 3.81 | [Clinical effects of gabapentin on the treatment of pruritus of scar resulting from deep partial-thickness burn]. ( Bing, Z; Qiang, W; Wei, L; Zheng, L, 2015) |
| "To study the clinical effects of gabapentin on the treatment of pruritus of scar resulting from deep partial-thickness burn." | 3.81 | [Clinical effects of gabapentin on the treatment of pruritus of scar resulting from deep partial-thickness burn]. ( Bing, Z; Qiang, W; Wei, L; Zheng, L, 2015) |
| " We combine pharmacological, genetic, and electrophysiological approaches to show that cortical GluK1-containing kainate (KA) receptors are involved in scratching induced by histamine and non-histamine-dependent itching stimuli." | 3.79 | Cortical GluK1 kainate receptors modulate scratching in adult mice. ( Chen, T; Descalzi, G; Koga, K; Li, XY; Yamada, K; Zhuo, M, 2013) |
| " Pregabalin was administered to treat the pruritus, and a considerable improvement was observed." | 3.79 | Successful treatment of chronic intractable itching using oral pregabalin in a patient with diabetes and systemic prurigo nodularis: a case report of an iliopsoas muscle abscess. ( Goto, A; Goto, M; Hachiya, R; Ihana, N; Imai, K; Inoue, K; Kajio, H; Kishimoto, M; Noda, M; Noto, H; Ono, K; Tsujimoto, T; Yamamoto-Honda, R, 2013) |
| " Gabapentin has been successfully used to treat cutaneous pain and pruritus in a variety of conditions." | 3.77 | A case of post-herpetic itch resolved with gabapentin. ( Jagdeo, J; Kroshinsky, D, 2011) |
| "We evaluated the effect of pregabalin in the treatment of uraemic pruritus not due to secondary hyperparathyroidism." | 3.76 | The use of pregabalin in the treatment of uraemic pruritus in haemodialysis patients. ( Alivanis, P; Aperis, G; Arvanitis, A; Paliouras, C; Zervos, A, 2010) |
| "To evaluate the efficacy of gabapentin for the treatment of uremic pruritus (UP)." | 3.74 | Role of gabapentin in the treatment of uremic pruritus. ( Gommer, J; Scates, AC; Vila, T, 2008) |
| "Literature retrieval was accessed through MEDLINE (1950-March week 3, 2008; In-Process & Other Non-Indexed Citations, April 1, 2008) and International Pharmaceutical Abstracts (1970-March 2008) using the terms gabapentin, pruritus, itch, urem$ (truncated), dialysis, and kidney disease." | 3.74 | Role of gabapentin in the treatment of uremic pruritus. ( Gommer, J; Scates, AC; Vila, T, 2008) |
| "We describe the use of gabapentin for the treatment of itching in wound healing in 35 children." | 3.72 | Gabapentin for the treatment of itching produced by burns and wound healing in children: a pilot study. ( Mendham, JE, 2004) |
| "Gabapentin is a promising and a well-tolerated treatment option for patients with UP." | 2.82 | Gabapentin: A promising therapy for uremic pruritus in hemodialysis patients: A randomized-controlled trial and review of literature. ( Abdelkhalik, Z; Alkot, R; Eldesouky, F; Farag, F; Nofal, A; Nofal, E, 2016) |
| "To evaluate efficacy, appropriate dosing regimen and safety of gabapentin on UP in hemodialysis (HD) patients." | 2.82 | Gabapentin: A promising therapy for uremic pruritus in hemodialysis patients: A randomized-controlled trial and review of literature. ( Abdelkhalik, Z; Alkot, R; Eldesouky, F; Farag, F; Nofal, A; Nofal, E, 2016) |
| "Ondansetron has negligible effect on uremic pruritus and is expensive." | 2.80 | Comparison of pregabalin with ondansetron in treatment of uraemic pruritus in dialysis patients: a prospective, randomized, double-blind study. ( Jiao, S; Meng, J; Ren, W; Xiao, Y; Yue, J; Zhao, T, 2015) |
| "Pruritus is common among patients with end-stage renal disease undergoing dialysis, and the pathogenesis can be explained by several mechanisms." | 2.80 | Comparison of pregabalin with ondansetron in treatment of uraemic pruritus in dialysis patients: a prospective, randomized, double-blind study. ( Jiao, S; Meng, J; Ren, W; Xiao, Y; Yue, J; Zhao, T, 2015) |
| "The average pretreatment pruritus score was 9." | 2.78 | Use of pregabalin in the management of chronic uremic pruritus. ( Grenader, T; Lifschitz, M; Shavit, L; Slotki, I, 2013) |
| " Drug dosage was determined by initial VAS (visual analog scale) scores." | 2.78 | A four arm, double blind, randomized and placebo controlled study of pregabalin in the management of post-burn pruritus. ( Ahuja, RB; Gupta, GK, 2013) |
| "gabapentin has marginal efficacy." | 2.77 | Uremic pruritus in hemodialysis patients: treatment with desloratidine versus gabapentin. ( Barrón, B; Lauxmann, JE; Marquez, D; Martinatto, C; Novoa, PA; Orías, M; Peixoto, AJ; Ramonda, C; Romero, CA; Vukelic, VL, 2012) |
| "Desloratadine was well tolerated." | 2.77 | Uremic pruritus in hemodialysis patients: treatment with desloratidine versus gabapentin. ( Barrón, B; Lauxmann, JE; Marquez, D; Martinatto, C; Novoa, PA; Orías, M; Peixoto, AJ; Ramonda, C; Romero, CA; Vukelic, VL, 2012) |
| "Uremic pruritus is common among dialysis patients." | 2.77 | Uremic pruritus in hemodialysis patients: treatment with desloratidine versus gabapentin. ( Barrón, B; Lauxmann, JE; Marquez, D; Martinatto, C; Novoa, PA; Orías, M; Peixoto, AJ; Ramonda, C; Romero, CA; Vukelic, VL, 2012) |
| "Pruritus is common in dialysis patients." | 2.77 | Pregabalin versus gabapentin in the treatment of neuropathic pruritus in maintenance haemodialysis patients: a prospective, crossover study. ( Atalay, H; Biyik, Z; Covic, A; Gaipov, A; Goldsmith, D; Guney, F; Kanbay, M; Solak, Y; Turk, S, 2012) |
| "Gabapentin and pregabalin improved both neuropathic pain and pruritus significantly." | 2.77 | Pregabalin versus gabapentin in the treatment of neuropathic pruritus in maintenance haemodialysis patients: a prospective, crossover study. ( Atalay, H; Biyik, Z; Covic, A; Gaipov, A; Goldsmith, D; Guney, F; Kanbay, M; Solak, Y; Turk, S, 2012) |
| "Treatment of neuropathic pain with either pregabalin or gabapentin effectively ameliorates uraemic itch." | 2.77 | Pregabalin versus gabapentin in the treatment of neuropathic pruritus in maintenance haemodialysis patients: a prospective, crossover study. ( Atalay, H; Biyik, Z; Covic, A; Gaipov, A; Goldsmith, D; Guney, F; Kanbay, M; Solak, Y; Turk, S, 2012) |
| "Gabapentin is an antiepileptic drug which has been successfully used to manage neuropathic pain, and is reporting to be successful in management of all forms of itch." | 2.76 | A comparative analysis of cetirizine, gabapentin and their combination in the relief of post-burn pruritus. ( Ahuja, RB; Gupta, G; Gupta, R; Shrivastava, P, 2011) |
| "Post-burn pruritis is a very distressing symptom having a reported incidence between 80 and 100%." | 2.76 | A comparative analysis of cetirizine, gabapentin and their combination in the relief of post-burn pruritus. ( Ahuja, RB; Gupta, G; Gupta, R; Shrivastava, P, 2011) |
| "Gabapentin is an effective agent in treating uremic pruritus." | 2.74 | Gabapentin and uremic pruritus in hemodialysis patients. ( Eskandari, D; Ganji, MR; Khashayar, P; Meysamie, AP; Razeghi, E; Togha, M, 2009) |
| "Pruritus is a common and bothersome problem in 30-50% of hemodialysis patients." | 2.74 | Gabapentin and uremic pruritus in hemodialysis patients. ( Eskandari, D; Ganji, MR; Khashayar, P; Meysamie, AP; Razeghi, E; Togha, M, 2009) |
| "Gabapentin is an effective drug in the management of neuropathic pain." | 2.73 | Gabapentin: a promising drug for the treatment of uremic pruritus. ( Harandi, AA; Khanbabapour, S; Mohseni, M; Naini, AE; Seirafiyan, S; Shahidi, S, 2007) |
| "Despite advances made in treatment, uremic pruritus remains a common and distressing symptom in patients on hemodialysis (HD)." | 2.73 | Gabapentin: a promising drug for the treatment of uremic pruritus. ( Harandi, AA; Khanbabapour, S; Mohseni, M; Naini, AE; Seirafiyan, S; Shahidi, S, 2007) |
| "Gabapentin is an anticonvulsant and had been reported to be effective in some chronic pruritus conditions." | 2.73 | Preoperative gabapentin prevents intrathecal morphine-induced pruritus after orthopedic surgery. ( Chang, FL; Ho, ST; Lee, CH; Sheen, MJ; Tsung, YC, 2008) |
| "Pruritus is the most common side effect of intrathecal morphine." | 2.73 | Preoperative gabapentin prevents intrathecal morphine-induced pruritus after orthopedic surgery. ( Chang, FL; Ho, ST; Lee, CH; Sheen, MJ; Tsung, YC, 2008) |
| "Pruritus was evaluated at 3, 6, 9, 12, and 24 h after intrathecal morphine administration." | 2.73 | Preoperative gabapentin prevents intrathecal morphine-induced pruritus after orthopedic surgery. ( Chang, FL; Ho, ST; Lee, CH; Sheen, MJ; Tsung, YC, 2008) |
| "Gabapentin was associated with an increase in mean HSA, in contrast to the placebo, which was associated with a decrease." | 2.72 | Gabapentin in patients with the pruritus of cholestasis: a double-blind, randomized, placebo-controlled trial. ( Bergasa, NV; Engler, D; Ginsburg, IH; McGee, M, 2006) |
| "Pruritus is defined as the second order of nociception, the first being pain; thus, there is a rationale to study gabapentin, a drug that increases the threshold to experience nociception." | 2.72 | Gabapentin in patients with the pruritus of cholestasis: a double-blind, randomized, placebo-controlled trial. ( Bergasa, NV; Engler, D; Ginsburg, IH; McGee, M, 2006) |
| "Gabapentin is an anticonvulsant that alleviates neuropathic pain." | 2.71 | Gabapentin therapy for pruritus in haemodialysis patients: a randomized, placebo-controlled, double-blind trial. ( Celiker, H; Gunal, AI; Gunal, SY; Kirciman, E; Ozalp, G; Yoldas, TK, 2004) |
| "Gabapentin or placebo were administered thrice weekly, at the end of haemodialysis sessions." | 2.71 | Gabapentin therapy for pruritus in haemodialysis patients: a randomized, placebo-controlled, double-blind trial. ( Celiker, H; Gunal, AI; Gunal, SY; Kirciman, E; Ozalp, G; Yoldas, TK, 2004) |
| "Uraemic pruritus is a common and distressing symptom in patients on haemodialysis for chronic renal failure." | 2.71 | Gabapentin therapy for pruritus in haemodialysis patients: a randomized, placebo-controlled, double-blind trial. ( Celiker, H; Gunal, AI; Gunal, SY; Kirciman, E; Ozalp, G; Yoldas, TK, 2004) |
| "Dermatologists play a key role in the treatment of CTCL-pruritus by guiding the patient in the importance of preserving the integrity of the skin barrier." | 2.58 | Pruritus in Cutaneous T-Cell Lymphoma and Its Management. ( Guitart, J; Martinez-Escala, ME; Serrano, L; Zhou, XA, 2018) |
| "Pruritus is a common symptom in cutaneous T-cell lymphoma (CTCL) and critically affects the quality of life of patients." | 2.58 | Pruritus in Cutaneous T-Cell Lymphoma and Its Management. ( Guitart, J; Martinez-Escala, ME; Serrano, L; Zhou, XA, 2018) |
| "Any intervention for the treatment of uremic pruritus was included." | 2.55 | Treatment of Uremic Pruritus: A Systematic Review. ( Askin, N; Bohm, C; Komenda, P; Lerner, B; Rigatto, C; Shaw, J; Simonsen, E; Tangri, N, 2017) |
| "Uremic pruritus is a common and burdensome symptom afflicting patients with advanced chronic kidney disease (CKD) and has been declared a priority for CKD research by patients." | 2.55 | Treatment of Uremic Pruritus: A Systematic Review. ( Askin, N; Bohm, C; Komenda, P; Lerner, B; Rigatto, C; Shaw, J; Simonsen, E; Tangri, N, 2017) |
| "In some respects, neuropathic pain can be considered a "disease" of the nervous system, with features in common with trauma-induced seizures." | 2.53 | Cell transplants to treat the "disease" of neuropathic pain and itch. ( Basbaum, AI; Bráz, JM, 2016) |
| "Chronic pruritus is a distressing symptom that is often refractory to treatment." | 2.53 | Gabapentin and pregabalin for the treatment of chronic pruritus. ( Kwatra, SG; Matsuda, KM; Schonfeld, AR; Sharma, D, 2016) |
| "The risk ratios (95% CI) for postoperative nausea, vomiting, pruritus and sedation with gabapentin were: 0." | 2.52 | A systematic review and meta-regression analysis of prophylactic gabapentin for postoperative pain. ( Doleman, B; Faleiro, RJ; Heinink, TP; Lund, JN; Read, DJ; Williams, JP, 2015) |
| "Gabapentin reduced postoperative pain scores on a 10-point scale at 1 h, 2 h, 6 h, 12 h and 24 h by a mean (95% CI) of: 1." | 2.52 | A systematic review and meta-regression analysis of prophylactic gabapentin for postoperative pain. ( Doleman, B; Faleiro, RJ; Heinink, TP; Lund, JN; Read, DJ; Williams, JP, 2015) |
| "Post burn pruritus is a well recognised symptom in almost all burn patients." | 2.48 | Post burn pruritus--a review of current treatment options. ( Gupta, AK; Lamba, S; Paul, MK; Prabha, R; Rao, AL; Zachariah, JR, 2012) |
| "Gabapentin has an antipruritus effect, which its efficacy in reducing pruritus induced by intrathecal morphine has not been well documented." | 2.48 | Single dose of gabapentin for prophylaxis intrathecal morphine-induced pruritus in orthopedic surgery: a randomized controlled trial. ( Chiravanich, W; Kovitwanawong, N; Oofuvong, M, 2012) |
| "The pruritus was evaluated at 1, 2, 3, 4, 6, 9, 12 and 24 hours after intrathecal morphine administration." | 2.48 | Single dose of gabapentin for prophylaxis intrathecal morphine-induced pruritus in orthopedic surgery: a randomized controlled trial. ( Chiravanich, W; Kovitwanawong, N; Oofuvong, M, 2012) |
| "Itch (pruritus) is a common unpleasant feeling, often accompanied by the urge of scratching the skin." | 1.91 | Antipruritic effects of geraniol on acute and chronic itch via modulating spinal GABA/GRPR signaling. ( Chu, YX; Du, LX; Maoying, QL; Mi, WL; Qiao, Z; Wang, YQ; Yang, YC; Yang, YY; Yi, T; Zhu, JY, 2023) |
| "Gabapentin was used by 45% as first-, second-, or third-line treatment." | 1.46 | International Comparisons of Prevalence, Awareness, and Treatment of Pruritus in People on Hemodialysis. ( Bieber, BA; Ecder, T; Graham-Brown, M; Hasegawa, T; Kleophas, W; Larkina, M; Pisoni, RL; Rayner, HC; Robinson, BM; Tentori, F; van der Veer, SN; Wang, M, 2017) |
| "Gabapentin is a viable treatment for conservatively managed CKD and ESKD patients with pruritus and/or RLS, but side effects are common." | 1.42 | Efficacy and safety of gabapentin for uremic pruritus and restless legs syndrome in conservatively managed patients with chronic kidney disease. ( Brennan, F; Brown, MA; Cheikh Hassan, HI; Collett, G; Josland, EA, 2015) |
| " We compared dosing and side effects in 34 CKD/ESKD patients with similar patients receiving HD (n = 15)." | 1.42 | Efficacy and safety of gabapentin for uremic pruritus and restless legs syndrome in conservatively managed patients with chronic kidney disease. ( Brennan, F; Brown, MA; Cheikh Hassan, HI; Collett, G; Josland, EA, 2015) |
| "Pruritus and restless legs syndrome (RLS) frequently affect patients with chronic kidney disease (CKD) and end-stage kidney disease (ESKD), impacting the quality of life." | 1.42 | Efficacy and safety of gabapentin for uremic pruritus and restless legs syndrome in conservatively managed patients with chronic kidney disease. ( Brennan, F; Brown, MA; Cheikh Hassan, HI; Collett, G; Josland, EA, 2015) |
| "Itching was induced via neonatal capsaicin treatment in Sprague-Dawley rats (itching rats), and scratching behavior of the control, itching, and gabapentin (GBP)-treated itching rats was compared." | 1.42 | Investigation of the pruritus-induced functional activity in the rat brain using manganese-enhanced MRI. ( Jeong, KY; Kang, JH, 2015) |
| "Compared with that before treatment, the itching degree of patients with light, moderate, and severe itching in placebo group was not relieved after treatment; the itching degree of patients with moderate or severe itching in cetirizine group was alleviated after treatment, but not in patients with light itching; itching degree of all patients in gabapentin group was significantly relieved after treatment." | 1.42 | [Clinical effects of gabapentin on the treatment of pruritus of scar resulting from deep partial-thickness burn]. ( Bing, Z; Qiang, W; Wei, L; Zheng, L, 2015) |
| "Treatment with gabapentin led to a prompt reduction of the symptoms." | 1.39 | Episodic itch in a case of spinal glioma. ( Dihné, M; Lerche, H; Wolking, S, 2013) |
| "Pregabalin was administered to treat the pruritus, and a considerable improvement was observed." | 1.39 | Successful treatment of chronic intractable itching using oral pregabalin in a patient with diabetes and systemic prurigo nodularis: a case report of an iliopsoas muscle abscess. ( Goto, A; Goto, M; Hachiya, R; Ihana, N; Imai, K; Inoue, K; Kajio, H; Kishimoto, M; Noda, M; Noto, H; Ono, K; Tsujimoto, T; Yamamoto-Honda, R, 2013) |
| "Brachioradial pruritus is a characteristic clinical condition with a deep intense itching, tingling or burning sensation localized to the dorsolateral part of the upper extremities." | 1.38 | [Brachioradial pruritus effectively treated with gabapentin]. ( Bygum, A; Uldall Pallesen, KA, 2012) |
| "Gabapentin has been successfully used to treat cutaneous pain and pruritus in a variety of conditions." | 1.37 | A case of post-herpetic itch resolved with gabapentin. ( Jagdeo, J; Kroshinsky, D, 2011) |
| "Herpes zoster is a skin disease encountered commonly in dermatologic practice." | 1.37 | A case of post-herpetic itch resolved with gabapentin. ( Jagdeo, J; Kroshinsky, D, 2011) |
| "Pruritus was determined using a visual analog scale." | 1.36 | GABA and GABA(A) receptor expression on immune cells in psoriasis: a pathophysiological role. ( Amatya, B; El-Nour, H; Nigam, R; Nordlind, K, 2010) |
| "Psoriasis is a chronic inflammatory disease in which pruritus is a common symptom." | 1.36 | GABA and GABA(A) receptor expression on immune cells in psoriasis: a pathophysiological role. ( Amatya, B; El-Nour, H; Nigam, R; Nordlind, K, 2010) |
| "Uraemic pruritus is a common and distressing symptom in patients undergoing haemodialysis." | 1.36 | The use of pregabalin in the treatment of uraemic pruritus in haemodialysis patients. ( Alivanis, P; Aperis, G; Arvanitis, A; Paliouras, C; Zervos, A, 2010) |
| "Gabapentin has been evaluated for the treatment of UP in 2 small, randomized, placebo-controlled studies, 1 pilot evaluation, and 1 index case." | 1.35 | Role of gabapentin in the treatment of uremic pruritus. ( Gommer, J; Scates, AC; Vila, T, 2008) |
| " Further well-designed trials are warranted to establish the most appropriate dosing regimen in patients on HD." | 1.35 | Role of gabapentin in the treatment of uremic pruritus. ( Gommer, J; Scates, AC; Vila, T, 2008) |
| "Within 24h of commencing treatment itching had improved significantly in all of the children." | 1.32 | Gabapentin for the treatment of itching produced by burns and wound healing in children: a pilot study. ( Mendham, JE, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (1.39) | 18.2507 |
| 2000's | 21 (29.17) | 29.6817 |
| 2010's | 49 (68.06) | 24.3611 |
| 2020's | 1 (1.39) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Yang, YY | 1 |
| Du, LX | 1 |
| Zhu, JY | 1 |
| Yi, T | 1 |
| Yang, YC | 1 |
| Qiao, Z | 1 |
| Maoying, QL | 1 |
| Chu, YX | 1 |
| Wang, YQ | 1 |
| Mi, WL | 1 |
| Lee, HG | 1 |
| Grossman, SK | 1 |
| Valdes-Rodriguez, R | 1 |
| Berenato, F | 1 |
| Korbutov, J | 1 |
| Chan, YH | 1 |
| Lavery, MJ | 1 |
| Yosipovitch, G | 2 |
| Heimall, J | 1 |
| Spergel, JM | 1 |
| Simonsen, E | 1 |
| Komenda, P | 1 |
| Lerner, B | 1 |
| Askin, N | 1 |
| Bohm, C | 1 |
| Shaw, J | 1 |
| Tangri, N | 1 |
| Rigatto, C | 1 |
| Rayner, HC | 1 |
| Larkina, M | 1 |
| Wang, M | 1 |
| Graham-Brown, M | 1 |
| van der Veer, SN | 1 |
| Ecder, T | 1 |
| Hasegawa, T | 1 |
| Kleophas, W | 1 |
| Bieber, BA | 1 |
| Tentori, F | 1 |
| Robinson, BM | 1 |
| Pisoni, RL | 1 |
| Akiyama, T | 1 |
| Andoh, T | 1 |
| Ohtsuka, E | 1 |
| Nojima, H | 1 |
| Ouchi, H | 1 |
| Takahata, H | 1 |
| Kuraishi, Y | 1 |
| Serrano, L | 1 |
| Martinez-Escala, ME | 1 |
| Zhou, XA | 1 |
| Guitart, J | 1 |
| Reszke, R | 1 |
| Szepietowski, JC | 1 |
| Rayner, H | 1 |
| Baharani, J | 1 |
| Smith, S | 1 |
| Suresh, V | 1 |
| Dasgupta, I | 1 |
| Sarifakioglu, E | 1 |
| Onur, O | 1 |
| Bernhard, JD | 3 |
| Pfisterer, M | 1 |
| Descalzi, G | 1 |
| Chen, T | 1 |
| Koga, K | 1 |
| Li, XY | 1 |
| Yamada, K | 1 |
| Zhuo, M | 1 |
| Wolking, S | 1 |
| Lerche, H | 1 |
| Dihné, M | 1 |
| Imai, K | 1 |
| Kishimoto, M | 1 |
| Tsujimoto, T | 1 |
| Yamamoto-Honda, R | 1 |
| Ihana, N | 1 |
| Ono, K | 1 |
| Hachiya, R | 1 |
| Inoue, K | 1 |
| Goto, M | 1 |
| Goto, A | 1 |
| Noto, H | 1 |
| Kajio, H | 1 |
| Noda, M | 1 |
| Mettang, T | 2 |
| Kremer, AE | 1 |
| Devigili, G | 1 |
| Eleopra, R | 1 |
| Pierro, T | 1 |
| Lombardi, R | 1 |
| Rinaldo, S | 1 |
| Lettieri, C | 1 |
| Faber, CG | 2 |
| Merkies, ISJ | 1 |
| Waxman, SG | 1 |
| Lauria, G | 1 |
| Yong, AS | 1 |
| Lee, KY | 1 |
| Yue, J | 1 |
| Jiao, S | 1 |
| Xiao, Y | 1 |
| Ren, W | 1 |
| Zhao, T | 1 |
| Meng, J | 1 |
| Cheikh Hassan, HI | 1 |
| Brennan, F | 1 |
| Collett, G | 1 |
| Josland, EA | 1 |
| Brown, MA | 1 |
| Jeong, KY | 1 |
| Kang, JH | 1 |
| Doleman, B | 1 |
| Heinink, TP | 1 |
| Read, DJ | 1 |
| Faleiro, RJ | 1 |
| Lund, JN | 1 |
| Williams, JP | 1 |
| Zheng, L | 1 |
| Bing, Z | 1 |
| Wei, L | 1 |
| Qiang, W | 1 |
| Basbaum, AI | 1 |
| Bráz, JM | 1 |
| Nofal, E | 1 |
| Farag, F | 1 |
| Nofal, A | 1 |
| Eldesouky, F | 1 |
| Alkot, R | 1 |
| Abdelkhalik, Z | 1 |
| Zhai, L | 1 |
| Song, Z | 1 |
| Liu, K | 1 |
| Matsuda, KM | 1 |
| Sharma, D | 1 |
| Schonfeld, AR | 1 |
| Kwatra, SG | 1 |
| Ward, RE | 1 |
| Veerula, VL | 1 |
| Ezra, N | 1 |
| Travers, JB | 1 |
| Mousdicas, N | 1 |
| Mao, Y | 1 |
| Wu, L | 1 |
| Ding, W | 1 |
| Pongcharoen, P | 1 |
| Fleischer, AB | 1 |
| Şavk, E | 1 |
| Hoeijmakers, JG | 1 |
| Miedema, CJ | 1 |
| Merkies, IS | 1 |
| Vles, JS | 1 |
| Razeghi, E | 1 |
| Eskandari, D | 1 |
| Ganji, MR | 1 |
| Meysamie, AP | 1 |
| Togha, M | 1 |
| Khashayar, P | 1 |
| Clarke, H | 1 |
| Pereira, S | 1 |
| Kennedy, D | 1 |
| Andrion, J | 1 |
| Mitsakakis, N | 1 |
| Gollish, J | 1 |
| Katz, J | 1 |
| Kay, J | 1 |
| Nigam, R | 1 |
| El-Nour, H | 1 |
| Amatya, B | 1 |
| Nordlind, K | 1 |
| Yilmaz, S | 1 |
| Ceyhan, AM | 1 |
| Baysal Akkaya, V | 1 |
| Bang, SR | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Treatment Effect of Chinese Medicine Formula on Uremic Pruritus[NCT04650750] | Early Phase 1 | 60 participants (Anticipated) | Interventional | 2020-12-01 | Not yet recruiting | ||
| Prospective Randomized Study Evaluating the Efficacy of the Spherical Absorptive Carbon AST-120 in Hemodialysis Patients With Uremic Pruritus..[NCT04639674] | Phase 4 | 100 participants (Actual) | Interventional | 2020-07-02 | Completed | ||
| Effectiveness of Sertraline in Alleviating Uremic Pruritis in Hemodialysis Patients[NCT05341843] | Phase 2 | 60 participants (Actual) | Interventional | 2022-05-01 | Completed | ||
| A Double-Blind Randomized Placebo-Controlled Clinical Trial of Preoperative Gabapentin Prior to Vaginal Apical Suspension Prolapse Procedures[NCT05658887] | Phase 4 | 110 participants (Anticipated) | Interventional | 2023-01-01 | Enrolling by invitation | ||
| Opioid-Free Shoulder Arthroplasty[NCT03540030] | Phase 4 | 86 participants (Actual) | Interventional | 2016-09-30 | Completed | ||
| "Preoperative Gabapentin and Its Effects on Postoperative Analgesia in Patients Undergoing Cosmetic Breast Surgery"[NCT05997355] | 100 participants (Anticipated) | Interventional | 2023-09-01 | Not yet recruiting | |||
| Phenomics and Genomics of Clinically Relevant Chronic Postsurgical Pain: A Multicenter Prospective Study[NCT04798573] | 10,000 participants (Anticipated) | Observational | 2012-08-03 | Active, not recruiting | |||
| Pre-Emptive Analgesia in Ano-Rectal Surgery[NCT02402543] | 90 participants (Actual) | Interventional | 2014-06-30 | Completed | |||
| Aprepitant vs. Desloratadine in Non-small Cell Lung Cancer Patients With Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors Related Pruritus: A Prospective, Randomized Control, Double-blinded, Phase II Clinical Trial[NCT02646020] | Phase 2 | 138 participants (Actual) | Interventional | 2015-12-31 | Completed | ||
| Study of Gabapentin for the Pruritus of Cholestasis[NCT00058890] | Phase 3 | 15 participants (Actual) | Interventional | 2000-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
American Shoulder and Elbow Surgeons (ASES) Shoulder Score for pain and function. Range 0-100. Low score = worse shoulder condition. Function, disability, and pain subscores (all ranges 0-50), and are summed for total ASES score. (NCT03540030)
Timeframe: 2 Weeks
| Intervention | units on a scale (Median) |
|---|---|
| Observational | 54.3 |
| Non-Opioid Intervention | 54.2 |
Morphine milli-equivalents In-hospital post-operative. Continuous scale of MME, no defined better/worse. Measured as number and dose of medications taken. For example, if the patient received an opioid, the drug and dose was recorded and converted to MME. A time frame of when to assess opioid use in-hospital post-operative was not used but was a continuous monitor for rescue opioid from in-hospital post-operative through discharge. (NCT03540030)
Timeframe: In-hospital Stay
| Intervention | Morphine milli-equivalents (Median) |
|---|---|
| Observational | 45.0 |
| Non-Opioid Intervention | 19.0 |
Pain at patient discharge or 24-hours, whichever comes first - measured on a 0 (no pain) -10 (worst possible pain) numeric rating scale (NRS). A score of 0(no pain) is preferable to 10(worst possible pain) (NCT03540030)
Timeframe: 24 hours
| Intervention | score on a scale (Median) |
|---|---|
| Observational | 3.0 |
| Non-Opioid Intervention | 2.0 |
Simple Shoulder Test (SST) activity score. Range 0-12. 0 = worse activity score. (NCT03540030)
Timeframe: 2 Months
| Intervention | score on a scale (Median) |
|---|---|
| Observational | 6 |
| Non-Opioid Intervention | 6 |
Simple Shoulder Test (SST) activity score. Range 0-12. 0 = worse activity score. (NCT03540030)
Timeframe: 2 Weeks
| Intervention | score on a scale (Median) |
|---|---|
| Observational | 2.0 |
| Non-Opioid Intervention | 2.0 |
post-operative pain: measured on a 0 (no pain) -10 (worst) numeric rating scale (NRS) at 6hrs, 12hrs, 2 weeks, and 2 months. A score of 0(no pain) is preferable to 10(worst possible pain) (NCT03540030)
Timeframe: 6hrs, 12hrs, 2weeks, 2 months
| Intervention | score on a scale (Median) | |||
|---|---|---|---|---|
| 6 Hrs | 12 hrs | 2 weeks | 2 months | |
| Non-Opioid Intervention | 0.0 | 0 | 0.82 | 0 |
| Observational | 2 | 4 | 1.3 | 0.7 |
rate of constipation (NCT03540030)
Timeframe: 2 Months
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Yes | No | Unknown | |
| Non-Opioid Intervention | 4 | 27 | 4 |
| Observational | 7 | 21 | 2 |
rate of constipation (NCT03540030)
Timeframe: 2 Weeks
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Yes | No | Unknown | |
| Non-Opioid Intervention | 13 | 22 | 0 |
| Observational | 19 | 9 | 2 |
rate of falls (NCT03540030)
Timeframe: 2 Months
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Yes | No | Unknown | |
| Non-Opioid Intervention | 4 | 27 | 4 |
| Observational | 4 | 24 | 2 |
rate of falls (NCT03540030)
Timeframe: 2 Weeks
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Yes | No | Unknown | |
| Non-Opioid Intervention | 5 | 30 | 0 |
| Observational | 1 | 27 | 2 |
rate of nausea (NCT03540030)
Timeframe: 2 Months
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Yes | No | Unknown | |
| Non-Opioid Intervention | 1 | 30 | 0 |
| Observational | 0 | 28 | 2 |
rate of nausea (NCT03540030)
Timeframe: 2 Weeks
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Yes | No | Unknown | |
| Non-Opioid Intervention | 1 | 34 | 0 |
| Observational | 5 | 23 | 2 |
Satisfaction with overall pain using Numeric Pain Rating (NRS) scale. yes, no. No being better than yes. (NCT03540030)
Timeframe: 2 Months
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Yes | No | Unknown | |
| Non-Opioid Intervention | 29 | 2 | 4 |
| Observational | 23 | 5 | 2 |
Satisfaction with overall pain using Numeric Pain Rating (NRS) scale. yes, no. No being better than yes. (NCT03540030)
Timeframe: 2 Weeks
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| Yes | No | Unknown | |
| Non-Opioid Intervention | 34 | 1 | 0 |
| Observational | 27 | 1 | 2 |
quality of life using VR-12 subscores. Physical Health (PCS) subscore and Mental Health (MCS) subscore, not summed. Range reported in weighted units. Physical Health subscore: 1 point increase in PCS is associated with 6% lower total health care expenditures, 5% lower pharmacy expenditures, 9% lower rate of hospital inpatient visits, 4% lower rate of medical provider visits, 5% lower rate of hospital outpatient visits. Mental Health sub score a 1 point increase in MCS is associated with 7% lower total health care expenditures, 4% lower pharmacy expenditures, 15% lower rate of hospital inpatient visits, and 4% lower rate of medical provider visits. Both PCS/MCS are score 0-100 with 100 indicating the highest level of health. (NCT03540030)
Timeframe: 2 Months
| Intervention | score on a scale (Median) | |
|---|---|---|
| PCS | MCS | |
| Non-Opioid Intervention | 40.3 | 60.8 |
| Observational | 38.4 | 58.7 |
quality of life using VR-12 subscores. Physical Health (PCS) subscore and Mental Health (MCS) subscore, not summed. Range reported in weighted units. Physical Health subscore: 1 point increase in PCS is associated with 6% lower total health care expenditures, 5% lower pharmacy expenditures, 9% lower rate of hospital inpatient visits, 4% lower rate of medical provider visits, 5% lower rate of hospital outpatient visits. Mental Health sub score a 1 point increase in MCS is associated with 7% lower total health care expenditures, 4% lower pharmacy expenditures, 15% lower rate of hospital inpatient visits, and 4% lower rate of medical provider visits. Both PCS/MCS are score 0-100 with 100 indicating the highest level of health. (NCT03540030)
Timeframe: 2 Weeks
| Intervention | score on a scale (Median) | |
|---|---|---|
| PCS | MCS | |
| Non-Opioid Intervention | 35.0 | 59.1 |
| Observational | 36.7 | 56.3 |
16 reviews available for gamma-aminobutyric acid and Pruritus
| Article | Year |
|---|---|
Treatment of Uremic Pruritus: A Systematic Review.
Topics: Administration, Cutaneous; Amines; Analgesics; Anti-Asthmatic Agents; Antipruritics; Capsaicin; Crom | 2017 |
Treatment of Uremic Pruritus: A Systematic Review.
Topics: Administration, Cutaneous; Amines; Analgesics; Anti-Asthmatic Agents; Antipruritics; Capsaicin; Crom | 2017 |
Treatment of Uremic Pruritus: A Systematic Review.
Topics: Administration, Cutaneous; Amines; Analgesics; Anti-Asthmatic Agents; Antipruritics; Capsaicin; Crom | 2017 |
Treatment of Uremic Pruritus: A Systematic Review.
Topics: Administration, Cutaneous; Amines; Analgesics; Anti-Asthmatic Agents; Antipruritics; Capsaicin; Crom | 2017 |
Pruritus in Cutaneous T-Cell Lymphoma and Its Management.
Topics: Adrenal Cortex Hormones; Amines; Antidepressive Agents, Tricyclic; Antipruritics; Cyclohexanecarboxy | 2018 |
End-Stage Renal Disease Chronic Itch and Its Management.
Topics: Amines; Analgesics, Opioid; Anticonvulsants; Antipruritics; Chronic Disease; Cyclohexanecarboxylic A | 2018 |
Clinical practice. Chronic pruritus.
Topics: Amines; Antidepressive Agents, Tricyclic; Behavior Therapy; Chronic Disease; Cyclohexanecarboxylic A | 2013 |
Uremic pruritus.
Topics: Acupuncture Therapy; Amines; Anti-Inflammatory Agents; Calcium Channel Blockers; Cyclohexanecarboxyl | 2015 |
A systematic review and meta-regression analysis of prophylactic gabapentin for postoperative pain.
Topics: Amines; Analgesics; Analgesics, Opioid; Cyclohexanecarboxylic Acids; Drug Administration Schedule; D | 2015 |
A systematic review and meta-regression analysis of prophylactic gabapentin for postoperative pain.
Topics: Amines; Analgesics; Analgesics, Opioid; Cyclohexanecarboxylic Acids; Drug Administration Schedule; D | 2015 |
A systematic review and meta-regression analysis of prophylactic gabapentin for postoperative pain.
Topics: Amines; Analgesics; Analgesics, Opioid; Cyclohexanecarboxylic Acids; Drug Administration Schedule; D | 2015 |
A systematic review and meta-regression analysis of prophylactic gabapentin for postoperative pain.
Topics: Amines; Analgesics; Analgesics, Opioid; Cyclohexanecarboxylic Acids; Drug Administration Schedule; D | 2015 |
Cell transplants to treat the "disease" of neuropathic pain and itch.
Topics: Animals; Cell Transplantation; GABAergic Neurons; gamma-Aminobutyric Acid; Humans; Neuralgia; Prurit | 2016 |
The Effect of Gabapentin on Acute Postoperative Pain in Patients Undergoing Total Knee Arthroplasty: A Meta-Analysis.
Topics: Amines; Analgesics; Analgesics, Opioid; Arthroplasty, Replacement, Knee; Cyclohexanecarboxylic Acids | 2016 |
Gabapentin and pregabalin for the treatment of chronic pruritus.
Topics: Amines; Anti-Anxiety Agents; Chronic Disease; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma | 2016 |
The efficacy of preoperative administration of gabapentin/pregabalin in improving pain after total hip arthroplasty: a meta-analysis.
Topics: Amines; Analgesics; Arthroplasty, Replacement, Hip; Cyclohexanecarboxylic Acids; Dizziness; Gabapent | 2016 |
Itch Management: Systemic Agents.
Topics: Amines; Analgesics; Analgesics, Opioid; Anion Exchange Resins; Antidepressive Agents; Aprepitant; Ch | 2016 |
Neurologic Itch Management.
Topics: Acupuncture Therapy; Amines; Anesthetics, Local; Anticonvulsants; Antipruritics; Botulinum Toxins, T | 2016 |
Uremic Itch Management.
Topics: Acupuncture Therapy; Amines; Analgesics, Opioid; Anticonvulsants; Calcineurin Inhibitors; Cyclohexan | 2016 |
Post burn pruritus--a review of current treatment options.
Topics: Amines; Analgesics; Burns; Cyclohexanecarboxylic Acids; Emollients; Gabapentin; gamma-Aminobutyric A | 2012 |
Single dose of gabapentin for prophylaxis intrathecal morphine-induced pruritus in orthopedic surgery: a randomized controlled trial.
Topics: Adolescent; Adult; Aged; Amines; Analgesics, Opioid; Anesthesia, Spinal; Antipruritics; Cyclohexanec | 2012 |
Gabapentin for pruritus in palliative care.
Topics: Amines; Analgesics, Opioid; Burns; Cholestasis; Cyclohexanecarboxylic Acids; Dermatologic Agents; Ga | 2013 |
15 trials available for gamma-aminobutyric acid and Pruritus
| Article | Year |
|---|---|
Uraemic pruritus: relief of itching by gabapentin and pregabalin.
Topics: Adult; Aged; Aged, 80 and over; Amines; Analgesics; Comorbidity; Cyclohexanecarboxylic Acids; Dose-R | 2012 |
Comparison of pregabalin with ondansetron in treatment of uraemic pruritus in dialysis patients: a prospective, randomized, double-blind study.
Topics: Adult; Aged; Analgesics; Antipruritics; Double-Blind Method; Drug Therapy, Combination; Female; gamm | 2015 |
Gabapentin: A promising therapy for uremic pruritus in hemodialysis patients: A randomized-controlled trial and review of literature.
Topics: Adult; Aged; Amines; Cyclohexanecarboxylic Acids; Double-Blind Method; Excitatory Amino Acid Antagon | 2016 |
Gabapentin and uremic pruritus in hemodialysis patients.
Topics: Adult; Aged; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Double-Blind Method; Female; Gaba | 2009 |
Adding gabapentin to a multimodal regimen does not reduce acute pain, opioid consumption or chronic pain after total hip arthroplasty.
Topics: Acute Disease; Aged; Amines; Analgesics; Analgesics, Opioid; Anesthesia, Spinal; Arthroplasty, Repla | 2009 |
Adding gabapentin to a multimodal regimen does not reduce acute pain, opioid consumption or chronic pain after total hip arthroplasty.
Topics: Acute Disease; Aged; Amines; Analgesics; Analgesics, Opioid; Anesthesia, Spinal; Arthroplasty, Repla | 2009 |
Adding gabapentin to a multimodal regimen does not reduce acute pain, opioid consumption or chronic pain after total hip arthroplasty.
Topics: Acute Disease; Aged; Amines; Analgesics; Analgesics, Opioid; Anesthesia, Spinal; Arthroplasty, Repla | 2009 |
Adding gabapentin to a multimodal regimen does not reduce acute pain, opioid consumption or chronic pain after total hip arthroplasty.
Topics: Acute Disease; Aged; Amines; Analgesics; Analgesics, Opioid; Anesthesia, Spinal; Arthroplasty, Repla | 2009 |
Can gabapentin help reduce postoperative pain in arthroscopic rotator cuff repair? A prospective, randomized, double-blind study.
Topics: Aged; Amines; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Arthrosc | 2010 |
A comparative analysis of cetirizine, gabapentin and their combination in the relief of post-burn pruritus.
Topics: Adolescent; Adult; Aged; Amines; Analgesics; Burns; Cetirizine; Child; Cyclohexanecarboxylic Acids; | 2011 |
Use of pregabalin in the management of chronic uremic pruritus.
Topics: Aged; Analgesics; Anticonvulsants; Chronic Disease; Female; gamma-Aminobutyric Acid; Humans; Male; P | 2013 |
Uremic pruritus in hemodialysis patients: treatment with desloratidine versus gabapentin.
Topics: Amines; Cross-Over Studies; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Histam | 2012 |
Pregabalin versus gabapentin in the treatment of neuropathic pruritus in maintenance haemodialysis patients: a prospective, crossover study.
Topics: Adult; Aged; Amines; Analgesics; Antipruritics; Chi-Square Distribution; Cross-Over Studies; Cyclohe | 2012 |
A four arm, double blind, randomized and placebo controlled study of pregabalin in the management of post-burn pruritus.
Topics: Adult; Analgesics; Anti-Allergic Agents; Burns; Cetirizine; Coconut Oil; Double-Blind Method; Female | 2013 |
Gabapentin therapy for pruritus in haemodialysis patients: a randomized, placebo-controlled, double-blind trial.
Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyric Acid; Humans | 2004 |
Gabapentin in patients with the pruritus of cholestasis: a double-blind, randomized, placebo-controlled trial.
Topics: Adult; Amines; Analgesics; Cholestasis; Chronic Disease; Cyclohexanecarboxylic Acids; Double-Blind M | 2006 |
Gabapentin: a promising drug for the treatment of uremic pruritus.
Topics: Adult; Aged; Aged, 80 and over; Amines; Cyclohexanecarboxylic Acids; Double-Blind Method; Female; Ga | 2007 |
Preoperative gabapentin prevents intrathecal morphine-induced pruritus after orthopedic surgery.
Topics: Adult; Amines; Anesthesia, Spinal; Anesthetics, Local; Antipruritics; Bupivacaine; Cyclohexanecarbox | 2008 |
41 other studies available for gamma-aminobutyric acid and Pruritus
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Antipruritic effects of geraniol on acute and chronic itch via modulating spinal GABA/GRPR signaling.
Topics: Animals; Antipruritics; Bicuculline; Chloroquine; gamma-Aminobutyric Acid; Gastrin-Releasing Peptide | 2023 |
Topical ketamine-amitriptyline-lidocaine for chronic pruritus: A retrospective study assessing efficacy and tolerability.
Topics: Aged; Amines; Amitriptyline; Analgesics; Chronic Disease; Cyclohexanecarboxylic Acids; Drug Therapy, | 2017 |
New pathways for itching in patients with atopic dermatitis?
Topics: Animals; Antipruritics; Dermatitis, Atopic; Eczema; gamma-Aminobutyric Acid; Humans; Mice; Pruritus | 2017 |
International Comparisons of Prevalence, Awareness, and Treatment of Pruritus in People on Hemodialysis.
Topics: Aged; Aged, 80 and over; Amines; Antipruritics; Chronic Disease; Cyclohexanecarboxylic Acids; Female | 2017 |
International Comparisons of Prevalence, Awareness, and Treatment of Pruritus in People on Hemodialysis.
Topics: Aged; Aged, 80 and over; Amines; Antipruritics; Chronic Disease; Cyclohexanecarboxylic Acids; Female | 2017 |
International Comparisons of Prevalence, Awareness, and Treatment of Pruritus in People on Hemodialysis.
Topics: Aged; Aged, 80 and over; Amines; Antipruritics; Chronic Disease; Cyclohexanecarboxylic Acids; Female | 2017 |
International Comparisons of Prevalence, Awareness, and Treatment of Pruritus in People on Hemodialysis.
Topics: Aged; Aged, 80 and over; Amines; Antipruritics; Chronic Disease; Cyclohexanecarboxylic Acids; Female | 2017 |
Peripheral gabapentin regulates mosquito allergy-induced itch in mice.
Topics: Amines; Animals; Antipruritics; Calcium Channels; Culicidae; Cyclohexanecarboxylic Acids; Gabapentin | 2018 |
Women with scalp dysesthesia treated with pregabalin.
Topics: Adult; Analgesics; Female; gamma-Aminobutyric Acid; Humans; Pain; Paresthesia; Pregabalin; Pruritus; | 2013 |
[Palliative care in geriatrics].
Topics: Alzheimer Disease; Analgesics; Cooperative Behavior; gamma-Aminobutyric Acid; Geriatrics; Germany; H | 2013 |
Cortical GluK1 kainate receptors modulate scratching in adult mice.
Topics: Animals; Antipruritics; Cerebral Cortex; Electrophysiological Phenomena; gamma-Aminobutyric Acid; Ge | 2013 |
Episodic itch in a case of spinal glioma.
Topics: Aged; Amines; Analgesics; Cyclohexanecarboxylic Acids; Evoked Potentials, Somatosensory; Female; Gab | 2013 |
Successful treatment of chronic intractable itching using oral pregabalin in a patient with diabetes and systemic prurigo nodularis: a case report of an iliopsoas muscle abscess.
Topics: Administration, Oral; Administration, Topical; Adrenal Cortex Hormones; Aged; Antipruritics; Diabete | 2013 |
Paroxysmal itch caused by gain-of-function Nav1.7 mutation.
Topics: Adult; Antipruritics; Child, Preschool; DNA Mutational Analysis; Female; gamma-Aminobutyric Acid; Hu | 2014 |
Uremic pruritus is improved by gabapentin.
Topics: Aged, 80 and over; Amines; Analgesics; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric A | 2014 |
Efficacy and safety of gabapentin for uremic pruritus and restless legs syndrome in conservatively managed patients with chronic kidney disease.
Topics: Aged; Aged, 80 and over; Amines; Analgesics; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma- | 2015 |
Investigation of the pruritus-induced functional activity in the rat brain using manganese-enhanced MRI.
Topics: Amines; Animals; Animals, Newborn; Brain; Brain Mapping; Capsaicin; Contrast Media; Cyclohexanecarbo | 2015 |
[Clinical effects of gabapentin on the treatment of pruritus of scar resulting from deep partial-thickness burn].
Topics: Amines; Analgesics; Ascorbic Acid; Burns; Cetirizine; Cicatrix; Cyclohexanecarboxylic Acids; Gabapen | 2015 |
Multilevel symmetric neuropathic pruritus (MSNP) presenting as recalcitrant "generalized" pruritus.
Topics: Age Distribution; Aged; Amines; Chronic Disease; Cohort Studies; Cyclohexanecarboxylic Acids; Diseas | 2016 |
Small Fiber Neuropathy in Children: Two Case Reports Illustrating the Importance of Recognition.
Topics: Adolescent; Amines; Analgesics; Biopsy; Cyclohexanecarboxylic Acids; Duloxetine Hydrochloride; Eryth | 2016 |
GABA and GABA(A) receptor expression on immune cells in psoriasis: a pathophysiological role.
Topics: Adult; Aged; Female; gamma-Aminobutyric Acid; Humans; Immunohistochemistry; Lymphocytes; Macrophages | 2010 |
Brachioradial pruritus successfully treated with gabapentin.
Topics: Amines; Cyclohexanecarboxylic Acids; Dermatologic Agents; Forearm; Gabapentin; gamma-Aminobutyric Ac | 2010 |
The use of pregabalin in the treatment of uraemic pruritus in haemodialysis patients.
Topics: Adult; Aged; Aged, 80 and over; Analgesics; Antipruritics; Central Nervous System Agents; Female; ga | 2010 |
Treatment of neuropathic itch possibly due to trigeminal trophic syndrome with 0.1% topical tacrolimus and gabapentin.
Topics: Administration, Cutaneous; Amines; Analgesics; Antipruritics; Cyclohexanecarboxylic Acids; Drug Ther | 2010 |
A case of post-herpetic itch resolved with gabapentin.
Topics: Adult; Amines; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyric Acid; Herpes Zost | 2011 |
Efficacy and safety of pregabalin for the treatment of chronic pruritus in Korea.
Topics: Adult; Aged; Antipruritics; Chronic Disease; Female; gamma-Aminobutyric Acid; Humans; Male; Middle A | 2012 |
[Brachioradial pruritus effectively treated with gabapentin].
Topics: Amines; Antipruritics; Arm; Brachial Plexus Neuropathies; Cervical Vertebrae; Cyclohexanecarboxylic | 2012 |
Brachioradial pruritus: response to treatment with gabapentin.
Topics: Acetates; Aged; Amines; Arm; Cyclohexanecarboxylic Acids; Dermatologic Agents; Female; Gabapentin; g | 2004 |
Gabapentin for the treatment of itching produced by burns and wound healing in children: a pilot study.
Topics: Adolescent; Amines; Antipruritics; Burns; Child; Child Behavior Disorders; Child, Preschool; Cyclohe | 2004 |
[Brachioradial pruritus: a rare, localized, neuropathic form of itching].
Topics: Amines; Anticonvulsants; Cervical Vertebrae; Cyclohexanecarboxylic Acids; Female; Forearm; Gabapenti | 2006 |
Gabapentin for uraemic pruritus.
Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; Prurit | 2005 |
Re: Pruritus in patients with advanced cancer.
Topics: Cholestasis; Cholestyramine Resin; GABA Agonists; gamma-Aminobutyric Acid; Humans; Narcotic Antagoni | 2005 |
Efficacy of gabapentin in the management of pruritus of unknown origin.
Topics: Aged; Aged, 80 and over; Amines; Antipruritics; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Amino | 2005 |
Mirtazapine and gabapentin for reducing pruritus in cutaneous T-cell lymphoma.
Topics: Amines; Anticonvulsants; Antidepressive Agents, Tricyclic; Cyclohexanecarboxylic Acids; Gabapentin; | 2006 |
Efficacy of pregabalin in the management of cetuximab-related itch.
Topics: Analgesics; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Cetuxi | 2006 |
Uremic pruritus.
Topics: Amines; Analgesics, Non-Narcotic; Analgesics, Opioid; Capsaicin; Cyclohexanecarboxylic Acids; Gabape | 2006 |
Gabapentin use in chronic uraemic itch is in line with emerging pathogenetic hypothesis.
Topics: Amines; Chronic Disease; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; P | 2007 |
Gabapentin treatment for notalgia paresthetica, a common isolated peripheral sensory neuropathy.
Topics: Aged, 80 and over; Amines; Analgesics; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric A | 2007 |
Pregabalin in the treatment of chronic pruritus.
Topics: Anticonvulsants; Chronic Disease; gamma-Aminobutyric Acid; Humans; Pregabalin; Pruritus | 2008 |
Gabapentin as a therapeutic option in uremic pruritus.
Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; Prurit | 2008 |
Chronic hemicorporal prurigo related to a posttraumatic Brown-Séquard syndrome.
Topics: Adult; Anticonvulsants; Antipruritics; Brown-Sequard Syndrome; gamma-Aminobutyric Acid; Humans; Male | 2008 |
Role of gabapentin in the treatment of uremic pruritus.
Topics: Amines; Antipruritics; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; Kid | 2008 |
Gabapentin treatment for brachioradial pruritus.
Topics: Acetates; Administration, Oral; Amines; Arm; Cyclohexanecarboxylic Acids; Drug Administration Schedu | 1999 |