Page last updated: 2024-10-16

gamma-aminobutyric acid and Premature Birth

gamma-aminobutyric acid has been researched along with Premature Birth in 8 studies

gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.

Premature Birth: CHILDBIRTH before 37 weeks of PREGNANCY (259 days from the first day of the mother's last menstrual period, or 245 days after FERTILIZATION).

Research Excerpts

ExcerptRelevanceReference
" Gabapentin is currently FDA-approved for treating RLS and preliminary results have shown it may be effective for treating the most severe form of NVP, hyperemesis gravidarum (HG)."8.90Potential maternal symptomatic benefit of gabapentin and review of its safety in pregnancy. ( Guttuso, T; Shaman, M; Thornburg, LL, 2014)
" If future pregnancy registry data confirm this positive safety profile, gabapentin therapy would likely be a safe and effective treatment for RLS during pregnancy."6.50Potential maternal symptomatic benefit of gabapentin and review of its safety in pregnancy. ( Guttuso, T; Shaman, M; Thornburg, LL, 2014)
" Gabapentin is currently FDA-approved for treating RLS and preliminary results have shown it may be effective for treating the most severe form of NVP, hyperemesis gravidarum (HG)."4.90Potential maternal symptomatic benefit of gabapentin and review of its safety in pregnancy. ( Guttuso, T; Shaman, M; Thornburg, LL, 2014)
"Gamma-aminobutyric acid (GABA) and glutamatergic system perturbations following premature birth may explain neurodevelopmental deficits in the absence of structural brain injury."4.31Severity of prematurity and age impact early postnatal development of GABA and glutamate systems. ( Andescavage, N; Basu, SK; Chang, T; duPlessis, AJ; Kapse, KJ; Limperopoulos, C; Lopez, CA; Murnick, J; Pradhan, S; Sharker, YM, 2023)
" If future pregnancy registry data confirm this positive safety profile, gabapentin therapy would likely be a safe and effective treatment for RLS during pregnancy."2.50Potential maternal symptomatic benefit of gabapentin and review of its safety in pregnancy. ( Guttuso, T; Shaman, M; Thornburg, LL, 2014)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (62.50)24.3611
2020's3 (37.50)2.80

Authors

AuthorsStudies
Jin, XL1
Song, BH1
Zhao, XD1
Huang, GB1
Basu, SK1
Pradhan, S1
Sharker, YM1
Kapse, KJ1
Murnick, J1
Chang, T1
Lopez, CA1
Andescavage, N1
duPlessis, AJ1
Limperopoulos, C1
Hours, CM1
Gil, S1
Gressens, P2
Shaw, JC1
Palliser, HK1
Dyson, RM1
Berry, MJ1
Hirst, JJ1
Ordyan, NE1
Akulova, VK1
Mironova, VI1
Otellin, VA1
Kiss, JZ1
Vasung, L1
Petrenko, V1
Guttuso, T1
Shaman, M1
Thornburg, LL1
Verney, C1
Rees, S1
Biran, V1
Thompson, M1
Inder, T1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
"Determining the Effect of an Alternate Recovery Protocol Versus Current Standard of Care After Cesarean Section"[NCT03330119]Phase 31,494 participants (Actual)Interventional2017-10-04Terminated (stopped due to Lack of Funding/ Resident in charge graduated)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Narcotic Utilization

"total narcotic utilization measured with Morphine Milligram Equivalent (MME)~The conversion scale being used will be the Center for Disease Control and Prevention Morphine Equivalent Score.~Lower scores represent less opioid use and a better outcome. Higher scores represent more opioid use and a worse outcome." (NCT03330119)
Timeframe: From time of consent until hospital discharge (3 days)

InterventionMME (Mean)
Alternate Management33.3
Control47.2

Reviews

3 reviews available for gamma-aminobutyric acid and Premature Birth

ArticleYear
Neonatal outcomes after gamma-aminobutyric acid analog use during pregnancy: a meta-analysis of cohort studies.
    European journal of clinical pharmacology, 2022, Volume: 78, Issue:11

    Topics: Cohort Studies; Female; gamma-Aminobutyric Acid; Humans; Infant; Infant, Newborn; Pregnancy; Pregnan

2022
Process of cortical network formation and impact of early brain damage.
    Current opinion in neurology, 2014, Volume: 27, Issue:2

    Topics: Animals; Brain Injuries; Cerebral Cortex; gamma-Aminobutyric Acid; Humans; Interneurons; Nerve Net;

2014
Potential maternal symptomatic benefit of gabapentin and review of its safety in pregnancy.
    European journal of obstetrics, gynecology, and reproductive biology, 2014, Volume: 181

    Topics: Amines; Anticonvulsants; Birth Weight; Congenital Abnormalities; Cyclohexanecarboxylic Acids; Female

2014

Other Studies

5 other studies available for gamma-aminobutyric acid and Premature Birth

ArticleYear
Severity of prematurity and age impact early postnatal development of GABA and glutamate systems.
    Cerebral cortex (New York, N.Y. : 1991), 2023, 06-08, Volume: 33, Issue:12

    Topics: Brain Injuries; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Infant; Infant, Newborn; Inf

2023
Molecular and Cellular Insights: A Focus on Glycans and the HNK1 Epitope in Autism Spectrum Disorder.
    International journal of molecular sciences, 2023, Oct-13, Volume: 24, Issue:20

    Topics: Autism Spectrum Disorder; Epitopes; Female; gamma-Aminobutyric Acid; Glutamates; Humans; Infant, New

2023
Disruptions to the cerebellar GABAergic system in juvenile guinea pigs following preterm birth.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2018, Volume: 65

    Topics: Age Factors; Animals; Animals, Newborn; Calbindins; Cerebellum; Female; GABA Plasma Membrane Transpo

2018
Behavior Disorders Caused by Perinatal Hypoxia in Juvenile Rats and Their Correction with GABA Derivative.
    Bulletin of experimental biology and medicine, 2017, Volume: 164, Issue:2

    Topics: Animals; Animals, Newborn; Behavior, Animal; Disease Models, Animal; Female; Forelimb; gamma-Aminobu

2017
Neuronal damage in the preterm baboon: impact of the mode of ventilatory support.
    Journal of neuropathology and experimental neurology, 2010, Volume: 69, Issue:5

    Topics: Animals; Calbindin 2; Cell Count; Continuous Positive Airway Pressure; Disease Models, Animal; Femal

2010