gamma-aminobutyric acid and Postoperative Nausea and Vomiting studies

gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.

Postoperative Nausea and Vomiting: Emesis and queasiness occurring after anesthesia.

Research Excerpts

Excerpt	Relevance	Reference
"Adolescent patients undergoing idiopathic scoliosis surgery were randomized to receive a single preoperative dose of gabapentin 600 mg or placebo."	9.19	Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial. ( Campbell, F; Mayell, A; Peliowski, A; Srinivasan, I, 2014)
"A single preoperative dose of gabapentin did not show a significant difference in opioid consumption or pain scores in adolescents undergoing idiopathic scoliosis surgery."	9.19	Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial. ( Campbell, F; Mayell, A; Peliowski, A; Srinivasan, I, 2014)
"To evaluate the effect of gabapentin on the incidence and severity of postoperative nausea and vomiting (PONV) after open cholecystectomy."	9.14	Effects of preoperative gabapentin on postoperative nausea and vomiting after open cholecystectomy: a prospective randomized double-blind placebo-controlled study. ( Asefi, A; Ghaffarpasand, F; Heiran, HR; Khademi, S, 2010)
"Preoperative pregabalin administration (75-300 mg po) increased perioperative sedation in a dose-related fashion, but failed to reduce preoperative state anxiety, postoperative pain, or to improve the recovery process after minor elective surgery procedures."	9.14	The effect of pregabalin on preoperative anxiety and sedation levels: a dose-ranging study. ( Klein, K; Taylor, J; Tufanogullari, B; White, PF, 2009)
"Hemodynamics at 1, 3, 5, and 10 min after tracheal intubation, total remifentanil consumption during surgery, postoperative visual analog scale scores at 30 min, 1, 2, 4, 6, and 12 h, and postoperative nausea and vomiting were found to be significantly lower in group GD than in group G and group D (P < 0."	9.12	The preoperative use of gabapentin, dexamethasone, and their combination in varicocele surgery: a randomized controlled trial. ( Koç, S; Memis, D; Sut, N, 2007)
"Gabapentin and dexamethasone administered together an hour before varicocele surgery results in less laryngeal and tracheal intubation response, improves postoperative analgesia, and prevents postoperative nausea and vomiting better than individual administration of each drug."	9.12	The preoperative use of gabapentin, dexamethasone, and their combination in varicocele surgery: a randomized controlled trial. ( Koç, S; Memis, D; Sut, N, 2007)
"We investigated the effects of gabapentin and dexamethasone given together or separately 1 h before the start of surgery on laryngoscopy, tracheal intubation, intraoperative hemodynamics, opioid consumption, and postoperative pain in patients undergoing varicocele operations."	9.12	The preoperative use of gabapentin, dexamethasone, and their combination in varicocele surgery: a randomized controlled trial. ( Koç, S; Memis, D; Sut, N, 2007)
"However, gabapentin did not reduce postoperative pain significantly (p = 0."	6.75	Effects of preoperative gabapentin on postoperative nausea and vomiting after open cholecystectomy: a prospective randomized double-blind placebo-controlled study. ( Asefi, A; Ghaffarpasand, F; Heiran, HR; Khademi, S, 2010)
"Gabapentin was efficacious in reducing postoperative pain, total morphine consumption, and morphine-related complications following laparoscopic cholecystectomy."	6.55	The efficacy of gabapentin in reducing pain intensity and postoperative nausea and vomiting following laparoscopic cholecystectomy: A meta-analysis. ( Dong, Y; Tan, H; Wang, L; Zhang, J, 2017)
" In addition, there was a negative correlation between the gabapentin dosage and the occurrence of nausea and vomiting."	6.55	The efficacy of gabapentin in reducing pain intensity and postoperative nausea and vomiting following laparoscopic cholecystectomy: A meta-analysis. ( Dong, Y; Tan, H; Wang, L; Zhang, J, 2017)
" The following data were recorded: total daily pethidine and diclofenac consumption, numeric sedation score, and the postoperative nausea, vomiting, and dizziness scores."	5.19	Clinical study evaluating pregabalin efficacy and tolerability for pain management in patients undergoing laparoscopic cholecystectomy. ( Al Taher, WM; Bekawi, MS; El Wakeel, LM; Mageed, WM, 2014)
"Adolescent patients undergoing idiopathic scoliosis surgery were randomized to receive a single preoperative dose of gabapentin 600 mg or placebo."	5.19	Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial. ( Campbell, F; Mayell, A; Peliowski, A; Srinivasan, I, 2014)
"A single preoperative dose of gabapentin did not show a significant difference in opioid consumption or pain scores in adolescents undergoing idiopathic scoliosis surgery."	5.19	Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial. ( Campbell, F; Mayell, A; Peliowski, A; Srinivasan, I, 2014)
"Patients undergoing craniotomy received either placebo (group D) or gabapentin (600 mg) (group GD) premedication orally, 2 hours before induction of anesthesia."	5.17	The effect of gabapentin premedication on postoperative nausea, vomiting, and pain in patients on preoperative dexamethasone undergoing craniotomy for intracranial tumors. ( Misra, S; Parthasarathi, G; Vilanilam, GC, 2013)
"This study aimed to determine if preoperative oral administration of metoclopramide, chlorpromazine, gabapentin, or dexamethasone would effectively reduce postoperative nausea and vomiting (PONV) in the first 24 hours after surgery in patients undergoing maxillofacial trauma surgery."	5.17	A randomized double-blinded placebo controlled study of four interventions for the prevention of postoperative nausea and vomiting in maxillofacial trauma surgery. ( Gholami, M; Jahromi, HE; Rezaei, F, 2013)
"To evaluate the effect of gabapentin on the incidence and severity of postoperative nausea and vomiting (PONV) after open cholecystectomy."	5.14	Effects of preoperative gabapentin on postoperative nausea and vomiting after open cholecystectomy: a prospective randomized double-blind placebo-controlled study. ( Asefi, A; Ghaffarpasand, F; Heiran, HR; Khademi, S, 2010)
"Preoperative pregabalin administration (75-300 mg po) increased perioperative sedation in a dose-related fashion, but failed to reduce preoperative state anxiety, postoperative pain, or to improve the recovery process after minor elective surgery procedures."	5.14	The effect of pregabalin on preoperative anxiety and sedation levels: a dose-ranging study. ( Klein, K; Taylor, J; Tufanogullari, B; White, PF, 2009)
"We investigated the effects of gabapentin and dexamethasone given together or separately 1 h before the start of surgery on laryngoscopy, tracheal intubation, intraoperative hemodynamics, opioid consumption, and postoperative pain in patients undergoing varicocele operations."	5.12	The preoperative use of gabapentin, dexamethasone, and their combination in varicocele surgery: a randomized controlled trial. ( Koç, S; Memis, D; Sut, N, 2007)
"Hemodynamics at 1, 3, 5, and 10 min after tracheal intubation, total remifentanil consumption during surgery, postoperative visual analog scale scores at 30 min, 1, 2, 4, 6, and 12 h, and postoperative nausea and vomiting were found to be significantly lower in group GD than in group G and group D (P < 0."	5.12	The preoperative use of gabapentin, dexamethasone, and their combination in varicocele surgery: a randomized controlled trial. ( Koç, S; Memis, D; Sut, N, 2007)
"Gabapentin and dexamethasone administered together an hour before varicocele surgery results in less laryngeal and tracheal intubation response, improves postoperative analgesia, and prevents postoperative nausea and vomiting better than individual administration of each drug."	5.12	The preoperative use of gabapentin, dexamethasone, and their combination in varicocele surgery: a randomized controlled trial. ( Koç, S; Memis, D; Sut, N, 2007)
"116 consecutive patients scheduled for breast cancer surgery were prospectively scored according to pain, PONV and sedation after being introduced to a combined evidence-based, empiric multimodal opioid-sparing prevention and treatment regime consisting of Paracetamol, Celecoxib, Dextromethorphan, Gabapetin, Dexamethason and Ondansetron."	3.74	[Multimodal treatment of pain and nausea in breast cancer surgery]. ( Callesen, T; Gärtner, R; Kehlet, H; Kroman, N, 2008)
"Also, the incidence of postoperative nausea was significantly high in the placebo group (11/30) as compared to treatment groups A (2/30), B (3/30), and C (3/30) (P < 0."	2.78	A randomized double-blinded placebo controlled study of four interventions for the prevention of postoperative nausea and vomiting in maxillofacial trauma surgery. ( Gholami, M; Jahromi, HE; Rezaei, F, 2013)
"A dosage of 600 mg of gabapentin plus 4 mg of dexamethasone significantly reduced the 24-hour incidence of nausea and PONV."	2.78	The effect of gabapentin premedication on postoperative nausea, vomiting, and pain in patients on preoperative dexamethasone undergoing craniotomy for intracranial tumors. ( Misra, S; Parthasarathi, G; Vilanilam, GC, 2013)
"Meperidine intramuscularly was used to treat postoperative pain on VAS score and patients demand."	2.77	Effects of gabapentin on postoperative pain, nausea and vomiting after abdominal hysterectomy: a double blind randomized clinical trial. ( Ajori, L; Amiri, Z; Mazloomfard, MM; Nazari, L, 2012)
"Postoperative pain was reduced in the gabapentin group (1."	2.77	Analgesic effects of preoperative gabapentin after tongue reconstruction with the anterolateral thigh flap. ( Burd, A; Chiu, TW; Lau, EY; Leung, CC, 2012)
"Gabapentin is a gamma aminobutyric acid analogue that is known as an anticonvulsant drug."	2.77	Effect of gabapentin on postoperative pain and operation complications: a randomized placebo controlled trial. ( Abrishamkar, M; Ayatollahi, V; Bafghi, AT; Behdad, S; Tezerjani, MD, 2012)
"Prevention and treatment of postoperative pain and operation complications such as nausea and vomiting are most important concerns in postoperative care."	2.77	Effect of gabapentin on postoperative pain and operation complications: a randomized placebo controlled trial. ( Abrishamkar, M; Ayatollahi, V; Bafghi, AT; Behdad, S; Tezerjani, MD, 2012)
"Gabapentin has demonstrated analgesic effects in some studies."	2.77	Effects of gabapentin on postoperative pain, nausea and vomiting after abdominal hysterectomy: a double blind randomized clinical trial. ( Ajori, L; Amiri, Z; Mazloomfard, MM; Nazari, L, 2012)
"Postoperative pain was assessed by a telephone interview 1 and 3 months after operation."	2.76	Pregabalin has an opioid-sparing effect in elderly patients after cardiac surgery: a randomized placebo-controlled trial. ( Hammarén, E; Kontinen, VK; Pesonen, A; Raivio, P; Rosenberg, PH; Suojaranta-Ylinen, R; Tarkkila, P, 2011)
"Postoperative confusion was measured with the Confusion Assessment Method for the intensive care unit (CAM-ICU)."	2.76	Pregabalin has an opioid-sparing effect in elderly patients after cardiac surgery: a randomized placebo-controlled trial. ( Hammarén, E; Kontinen, VK; Pesonen, A; Raivio, P; Rosenberg, PH; Suojaranta-Ylinen, R; Tarkkila, P, 2011)
"We hypothesized that an antineuropathic pain drug like pregabalin could be helpful to optimize postoperative analgesia by reducing the requirement for opioids and their associated side effects."	2.75	Analgesic effects of a single preoperative dose of pregabalin after laparoscopic sleeve gastrectomy. ( Cabrera Schulmeyer, MC; de la Maza, J; Farias, C; Ovalle, C; Vives, I, 2010)
"Tramadol consumption was also reduced by 33% in gabapentin group."	2.75	Effect of preoperative gabapentin on postoperative pain and tramadol consumption after minilap open cholecystectomy: a randomized double-blind, placebo-controlled trial. ( Kumar, A; Mishra, AR; Mishra, S; Saraswat, N; Saxena, S; Srivastava, U, 2010)
"Sedation was common but the incidence of postoperative nausea and vomiting was significantly lower in gabapentin group."	2.75	Effect of preoperative gabapentin on postoperative pain and tramadol consumption after minilap open cholecystectomy: a randomized double-blind, placebo-controlled trial. ( Kumar, A; Mishra, AR; Mishra, S; Saraswat, N; Saxena, S; Srivastava, U, 2010)
"However, gabapentin did not reduce postoperative pain significantly (p = 0."	2.75	Effects of preoperative gabapentin on postoperative nausea and vomiting after open cholecystectomy: a prospective randomized double-blind placebo-controlled study. ( Asefi, A; Ghaffarpasand, F; Heiran, HR; Khademi, S, 2010)
"Gabapentin has opioid-sparing effects in adult surgical patients, but no reported studies have involved children and adolescents."	2.75	Gabapentin use in pediatric spinal fusion patients: a randomized, double-blind, controlled trial. ( Berens, RJ; Czarnecki, ML; Hainsworth, KR; Lyon, RM; Nelson, TJ; Rusy, LM; Tassone, JC; Thometz, JG; Weisman, SJ, 2010)
"Of 200 consecutive breast cancer patients, 191 received the full package."	2.75	Multimodal prevention of pain, nausea and vomiting after breast cancer surgery. ( Callesen, T; Gärtner, R; Kehlet, H; Kroman, N, 2010)
"General anaesthesia was performed."	2.74	Pregabalin and dexamethasone in combination with paracetamol for postoperative pain control after abdominal hysterectomy. A randomized clinical trial. ( Dahl, JB; Dierking, G; Fomsgaard, JS; Hilsted, KL; Lech, K; Lose, G; Mathiesen, O; Rasmussen, ML, 2009)
" We investigated the analgesic effect of pregabalin and dexamethasone in combination with paracetamol after abdominal hysterectomy."	2.74	Pregabalin and dexamethasone in combination with paracetamol for postoperative pain control after abdominal hysterectomy. A randomized clinical trial. ( Dahl, JB; Dierking, G; Fomsgaard, JS; Hilsted, KL; Lech, K; Lose, G; Mathiesen, O; Rasmussen, ML, 2009)
"Prevention and treatment of postoperative pain, nausea and vomiting continues to be a major challenge in postoperative care."	2.73	Effects of gabapentin on early postoperative pain, nausea and vomiting in laparoscopic surgery for assisted reproductive technologies. ( Mohammadi, SS; Seyedi, M, 2008)
"Spinal anaesthesia was performed."	2.73	Pregabalin and dexamethasone for postoperative pain control: a randomized controlled study in hip arthroplasty. ( Adamiec-Malmstroem, L; Dahl, JB; Graungaard, BK; Hilsted, KL; Holm, HE; Holst, PE; Jacobsen, LS; Mathiesen, O; Randall, S, 2008)
"Gabapentin might also reduce postoperative pain."	2.71	Gabapentin for the prevention of postoperative pain after vaginal hysterectomy. ( Haanpää, M; Kujansuu, E; Mennander, S; Pirhonen, R; Puura, A; Rintala, S; Rorarius, MG; Salmelin, R; Suominen, P; Yli-Hankala, A, 2004)
"Gabapentin was efficacious in reducing postoperative pain, total morphine consumption, and morphine-related complications following laparoscopic cholecystectomy."	2.55	The efficacy of gabapentin in reducing pain intensity and postoperative nausea and vomiting following laparoscopic cholecystectomy: A meta-analysis. ( Dong, Y; Tan, H; Wang, L; Zhang, J, 2017)
" In addition, there was a negative correlation between the gabapentin dosage and the occurrence of nausea and vomiting."	2.55	The efficacy of gabapentin in reducing pain intensity and postoperative nausea and vomiting following laparoscopic cholecystectomy: A meta-analysis. ( Dong, Y; Tan, H; Wang, L; Zhang, J, 2017)
"Gabapentin is a third-generation antiepileptic drug that selectively affects the nociceptive process and has been used for pain relief after surgery."	2.55	The Efficacy of Preoperative Gabapentin in Spinal Surgery: A Meta-Analysis of Randomized Controlled Trials. ( Han, C; Kuang, MJ; Ma, JX; Ma, XL, 2017)
"This meta-analysis of randomized controlled trials (RCTs) was performed to compare the use of gabapentin with placebo in open hysterectomy regarding (1) the mean difference (MD) of postoperative opioid requirements; (2) the changes of visual analogue scale (VAS) scores in two groups; and (3) incidence rate of adverse effects."	2.55	Is gabapentin effective and safe in open hysterectomy? A PRISMA compliant meta-analysis of randomized controlled trials. ( Han, C; Li, XD; Yu, WL, 2017)
"Gabapentin reduced postoperative pain scores on a 10-point scale at 1 h, 2 h, 6 h, 12 h and 24 h by a mean (95% CI) of: 1."	2.52	A systematic review and meta-regression analysis of prophylactic gabapentin for postoperative pain. ( Doleman, B; Faleiro, RJ; Heinink, TP; Lund, JN; Read, DJ; Williams, JP, 2015)
"The risk ratios (95% CI) for postoperative nausea, vomiting, pruritus and sedation with gabapentin were: 0."	2.52	A systematic review and meta-regression analysis of prophylactic gabapentin for postoperative pain. ( Doleman, B; Faleiro, RJ; Heinink, TP; Lund, JN; Read, DJ; Williams, JP, 2015)
"In the case of postoperative nausea and vomiting, administration of dexamethasone, droperidol and 5-HT3-antagonists is recommended, preferably in combination."	2.49	['Postoperative pain treatment' practice guideline revised]. ( Hollmann, MW; Houweling, PL; Molag, ML; van Boekel, RL; van Haelst, IM; Verbrugge, SJ, 2013)
" Reported adverse effects were also analysed."	2.47	Efficacy and safety of perioperative pregabalin for post-operative pain: a meta-analysis of randomized-controlled trials. ( Cateloy, F; Engelman, E, 2011)
"Gabapentin is a second generation anticonvulsant that is effective in the treatment of chronic neuropathic pain."	2.44	Gabapentin: a multimodal perioperative drug? ( Irwin, MG; Kong, VK, 2007)
"Both patients suffered from refractory postoperative nausea and vomiting, treated with multiple traditional antiemetic drugs but without relief."	1.42	Gabapentin for Postoperative Vomiting in Children Requiring Posterior Fossa Tumor Resection. ( Fan, PC; Tsai, KC; Yang, YL, 2015)
"116 consecutive patients scheduled for breast cancer surgery were prospectively scored according to pain, PONV and sedation after being introduced to a combined evidence-based, empiric multimodal opioid-sparing prevention and treatment regime consisting of Paracetamol, Celecoxib, Dextromethorphan, Gabapetin, Dexamethason and Ondansetron."	1.35	[Multimodal treatment of pain and nausea in breast cancer surgery]. ( Callesen, T; Gärtner, R; Kehlet, H; Kroman, N, 2008)

Research

Studies (48)

Authors

Clinical Trials (43)

Trial Overview

Trial Outcomes

"VAS Score 1: How Much Pain do You Feel in Your Operative Site When Resting?"

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	13 (27.08)	29.6817
2010's	35 (72.92)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Khezri, MB	1
Nasseh, N	1
Soltanian, G	1
Kim, KM	1
Huh, J	1
Lee, SK	1
Park, EY	1
Lee, JM	1
Kim, HJ	2
Li, XD	1
Han, C	2
Yu, WL	1
Wang, L	1
Dong, Y	1
Zhang, J	1
Tan, H	1
Kuang, MJ	1
Ma, JX	1
Ma, XL	1
Misra, S	1
Parthasarathi, G	1
Vilanilam, GC	1
Mathiesen, O	4
Dahl, B	1
Thomsen, BA	2
Kitter, B	2
Sonne, N	1
Dahl, JB	5
Kehlet, H	5
Tsai, KC	1
Yang, YL	1
Fan, PC	1
Jahromi, HE	1
Gholami, M	1
Rezaei, F	1
Houweling, PL	1
Molag, ML	1
van Boekel, RL	1
Verbrugge, SJ	1
van Haelst, IM	1
Hollmann, MW	1
Bekawi, MS	1
El Wakeel, LM	1
Al Taher, WM	1
Mageed, WM	1
Alayed, N	1
Alghanaim, N	1
Tan, X	1
Tulandi, T	1
Mayell, A	1
Srinivasan, I	1
Campbell, F	1
Peliowski, A	1
Mohamed, SJ	1
Kristensen, BB	1
Lindgaard, L	1
Bisgaard, T	1
Achuthan, S	1
Singh, I	1
Varthya, SB	1
Srinivasan, A	1
Chakrabarti, A	1
Hota, D	1
Doleman, B	1
Heinink, TP	1
Read, DJ	1
Faleiro, RJ	1
Lund, JN	1
Williams, JP	1
Morgan, B	1
Stanik-Hutt, J	1
Grant, MC	1
Lee, H	1
Page, AJ	1
Hobson, D	1
Wick, E	1
Wu, CL	1
Gärtner, R	3
Callesen, T	3
Kroman, N	3
Jacobsen, LS	1
Holm, HE	1
Randall, S	1
Adamiec-Malmstroem, L	1
Graungaard, BK	1
Holst, PE	1
Hilsted, KL	2
Mohammadi, SS	1
Seyedi, M	1
Rasmussen, ML	2
Dierking, G	2
Lech, K	1
Fomsgaard, JS	2
Lose, G	1
White, PF	1
Tufanogullari, B	1
Taylor, J	1
Klein, K	1
Clarke, H	2
Pereira, S	1
Kennedy, D	1
Andrion, J	1
Mitsakakis, N	2
Gollish, J	1
Katz, J	1
Kay, J	1
Cabrera Schulmeyer, MC	1
de la Maza, J	1
Ovalle, C	1
Farias, C	1
Vives, I	1
Srivastava, U	1
Kumar, A	1
Saxena, S	1
Mishra, AR	1
Saraswat, N	1
Mishra, S	1
Khademi, S	1
Ghaffarpasand, F	1
Heiran, HR	1
Asefi, A	1
Menda, F	1
Köner, O	1
Sayın, M	1
Ergenoğlu, M	1
Küçükaksu, S	1
Aykaç, B	1
Kim, SY	1
Jeong, JJ	1
Chung, WY	1
Nam, KH	1
Shim, YH	1
Rusy, LM	1
Hainsworth, KR	1
Nelson, TJ	1
Czarnecki, ML	1
Tassone, JC	1
Thometz, JG	1
Lyon, RM	1
Berens, RJ	1
Weisman, SJ	1
Bang, SR	1
Yu, SK	1
Kim, TH	1
Moore, A	1
Costello, J	1
Wieczorek, P	1
Shah, V	2
Taddio, A	1
Carvalho, JC	2
Pesonen, A	1
Suojaranta-Ylinen, R	1
Hammarén, E	1
Kontinen, VK	1
Raivio, P	1
Tarkkila, P	1
Rosenberg, PH	1
Engelman, E	1
Cateloy, F	1
Ajori, L	1
Nazari, L	1
Mazloomfard, MM	1
Amiri, Z	1
Chiu, TW	1
Leung, CC	1
Lau, EY	1
Burd, A	1
Chaparro, LE	1
Valdes, PA	1
Mira, M	1
Duque, L	1
Short, J	1
Downey, K	1
Bernstein, P	1
Behdad, S	1
Ayatollahi, V	1
Bafghi, AT	1
Tezerjani, MD	1
Abrishamkar, M	1
Duedahl, TH	1
Møiniche, S	1
Rømsing, J	1
Turan, A	1
Karamanlioğlu, B	1
Memiş, D	2
Usar, P	1
Pamukçu, Z	1
Türe, M	1
Rorarius, MG	1
Mennander, S	1
Suominen, P	1
Rintala, S	1
Puura, A	1
Pirhonen, R	1
Salmelin, R	1
Haanpää, M	1
Kujansuu, E	1
Yli-Hankala, A	1
Pandey, CK	1
Navkar, DV	1
Giri, PJ	1
Raza, M	1
Behari, S	1
Singh, RB	1
Singh, U	1
Singh, PK	1
Koç, S	1
Sut, N	1
Kong, VK	1
Irwin, MG	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Comparison of the Prophylactic Anti-emetic Efficacy of Gabapentin and Ramosetron in Patients Undergoing Laparoscopic Gynecological Surgery[NCT02617121]		120 participants (Anticipated)	Interventional	2015-11-30	Not yet recruiting
Gabapentin Regimens and Their Effects on Opioid Consumption[NCT03334903]	Phase 4	77 participants (Actual)	Interventional	2018-05-15	Completed
A Prospective Randomized Double Blind Trial to Assess the Effect of a Single Preoperative Dose of Gabapentin on Postoperative Opioid Consumption in Patients Undergoing Rhinoplasty[NCT03498261]	Phase 1	50 participants (Actual)	Interventional	2018-01-30	Active, not recruiting
Erector Spinae Plane Block in Lumbar Spinal Fusion : Double-blind, Randomized Controlled Trial.[NCT04904575]		130 participants (Anticipated)	Interventional	2022-01-03	Recruiting
Erector Spinae Plane Block in Lumbar Release Surgery : Double-blind, Randomized Controlled Trial[NCT04925882]		100 participants (Actual)	Interventional	2022-01-03	Completed
Pre-Emptive Analgesia in Ano-Rectal Surgery[NCT02402543]		90 participants (Actual)	Interventional	2014-06-30	Completed
Effects of Intra-Operative Ropivaciane Epidural Injection on Post-Operative Outcomes Following Elective Lumbar Fusion[NCT03035656]	Phase 4	228 participants (Anticipated)	Interventional	2019-03-01	Not yet recruiting
Gabapentin as a Pre-emptive Analgesic in Oral and Maxillofacial Surgical Procedures[NCT02957097]	Phase 4	0 participants (Actual)	Interventional	2019-09-30	Withdrawn (stopped due to Original PI left institution and the PI who took over was not able to initiate the study so it was never started.)
Single Dose Preoperative Gabapentin Use in Minimally Invasive Hysterectomy for Acute Pain Management[NCT02703259]	Phase 4	137 participants (Actual)	Interventional	2016-06-30	Completed
Administration of Pre-Operative Gabapentin to Patients Undergoing Laparoscopy: A Prospective Double-blinded, Placebo Controlled Randomized Study[NCT02359110]	Phase 4	112 participants (Actual)	Interventional	2015-06-30	Completed
Use of Gabapentin as Preanesthetic Medication in Oncologic Children Undergoing in Fast Procedures With Sevofluran[NCT03681574]	Phase 4	135 participants (Actual)	Interventional	2017-07-01	Completed
Placebo Controlled, Randomized,Gabapentin as Adjuvant for Postoperative Pain in Pediatric Orthopedic Surgery[NCT03005483]	Phase 4	40 participants (Actual)	Interventional	2014-01-31	Completed
Efficacy of Gabapentin as Adjuvant for Postoperative Pain in Pediatric Thoracic Surgery - a Randomized Quadruple Blind Study[NCT03393702]	Phase 4	104 participants (Actual)	Interventional	2017-05-09	Completed
Evaluation of Post-operative Pain in Bascom Cleft Lift Operation Receiving Multimodal Analgesia and Spinal Saddle Block in Day Case Surgery Setting.[NCT02196727]		32 participants (Actual)	Observational [Patient Registry]	2013-05-31	Completed
A Double-Blind Randomized Placebo-Controlled Clinical Trial of Preoperative Gabapentin Prior to Vaginal Apical Suspension Prolapse Procedures[NCT05658887]	Phase 4	110 participants (Anticipated)	Interventional	2023-01-01	Enrolling by invitation
Opioid-Free Shoulder Arthroplasty[NCT03540030]	Phase 4	86 participants (Actual)	Interventional	2016-09-30	Completed
Prophylaxy of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Surgery[NCT03202459]		60 participants (Anticipated)	Interventional	2017-03-02	Recruiting
Effect of Preoperative Pregabalin on Propofol Induction Dose[NCT01158859]	Phase 4	50 participants (Anticipated)	Interventional	2010-04-30	Completed
Perioperative Administration of Pregabalin in Laparoscopic Living Donor Nephrectomy (L-LDN) - an Adjuvance to Peroral Analgetic Treatment - a Randomized Controlled Study[NCT01059331]	Phase 4	80 participants (Actual)	Interventional	2010-02-28	Completed
Preoperative Use of Pregabalin and Analgesia Levels After Laparoscopic Cholecystectomy[NCT01321801]		50 participants (Actual)	Interventional	2009-11-30	Completed
Do Peri-operative High Doses of Intravenous Glucocorticoids Improve Short-term Functional Outcome After Direct Anterior Total Hip Arthroplasty? A Randomized, Single Surgeon, Placebo Controlled, Double Blind Study[NCT04317872]		70 participants (Anticipated)	Interventional	2020-07-01	Recruiting
The Effect of a Preoperative Single-dose Methylprednisolone on the Postoperative Rehabilitation After Abdominal Hysterectomy: A Prospective, Double Blinded, Placebo Controlled Study[NCT01106547]	Phase 4	55 participants (Anticipated)	Interventional	2009-08-31	Completed
Phenomics and Genomics of Clinically Relevant Chronic Postsurgical Pain: A Multicenter Prospective Study[NCT04798573]		10,000 participants (Anticipated)	Observational	2012-08-03	Active, not recruiting
Analgesic Effect of Pregabalin in Patients Undergoing Total Abdominal Hysterectomy[NCT01466101]		0 participants (Actual)	Interventional	2011-01-31	Withdrawn (stopped due to PI left the institution. No subjects screened or enrolled.)
Use of Preoperative Gabapentin in Patients Undergoing Laparoscopic Cholecystectomy[NCT03583892]		60 participants (Anticipated)	Observational [Patient Registry]	2018-07-01	Recruiting
Use of Single Dose Pre-Operative Pregabalin for Post-Operative Analgesia in Bilateral Head and Neck Cancer Surgery: A Randomized, Double-Blinded, Placebo-Controlled Trial[NCT03714867]	Phase 4	0 participants (Actual)	Interventional	2019-03-22	Withdrawn (stopped due to Inability to recruit patients)
Perioperative Administration of Pregabalin for Pain After Robot-assisted Endoscopic Thyroidectomy[NCT00905580]	Phase 4	99 participants (Actual)	Interventional	2009-05-31	Completed
Perioperative Methadone Use to Decrease Opioid Requirement in Pediatric Spinal Fusion Patients[NCT02558010]	Phase 3	58 participants (Actual)	Interventional	2016-02-01	Completed
Pain Control in Pediatric Posterior Spine Fusion Patients: The Effect of Gabapentin on Post-operative Opioid Use and Patient Satisfaction[NCT01977937]	Phase 4	55 participants (Actual)	Interventional	2013-11-30	Completed
Combined General Anesthesia Plus Paravertebral Block Versus General Anesthesia Plus Opioid Analgesia for Breast Cancer Surgery: A Prospective Randomized Trial[NCT01904266]		60 participants (Actual)	Interventional	2013-05-31	Completed
Multimodal Pain Treatment for Breast Cancer Surgery - a Prospective Cohort Study[NCT04875559]		236 participants (Actual)	Observational [Patient Registry]	2021-04-19	Completed
"Determining the Effect of an Alternate Recovery Protocol Versus Current Standard of Care After Cesarean Section"[NCT03330119]	Phase 3	1,494 participants (Actual)	Interventional	2017-10-04	Terminated (stopped due to Lack of Funding/ Resident in charge graduated)
Perioperative Multimodal General Anesthesia Focusing on Specific CNS Targets in Patients Undergoing Cardiac Surgeries[NCT04016740]	Early Phase 1	22 participants (Actual)	Interventional	2019-08-20	Completed
Peri-Operative Pregabalin for Reducing opIoid Consumption AfTer Cardiac surgEry: A Randomized Trial[NCT04517110]	Phase 3	17 participants (Actual)	Interventional	2021-04-09	Terminated (stopped due to The COVID-19 pandemic has reduced recruitment such that the study is no longer feasible)
Comparison of Periosteal and Subcutaneous Infusions of Articaine and Bupivacaine in Treatment of Acute Pain After Sternotomy[NCT01536717]	Phase 4	36 participants (Actual)	Interventional	2012-03-31	Suspended
Effects of Pre-operative Oral Pregabalin on Post Operative Morphine Consumption After Abdominal Hysterectomy With/Without Salpingo-oophorectomy Under Spinal Anesthesia With Intrathecal Morphine[NCT02285010]	Phase 4	125 participants (Actual)	Interventional	2014-11-30	Completed
Preemptive Analgesia With Amitryptyline for Prevention of Post-operative Pain in Women After Total Abdominal Hysterectomy: a Randomized Clinical Trial[NCT03587025]	Phase 3	150 participants (Actual)	Interventional	2015-06-01	Completed
Anaesthesiological Involvement in Postoperative Pain Treatment - A Questionnaire Survey at Danish Hospitals[NCT03496194]		42 participants (Actual)	Observational	2018-04-13	Completed
The Effect of Neurontin on Pain Management in the Acutely Burned Patient[NCT01265056]		53 participants (Actual)	Interventional	2010-02-28	Completed
The Effect of Gabapentin on Acute Pain and PONV in Bariatric Surgical Patients[NCT00886236]		62 participants (Actual)	Interventional	2008-02-29	Completed
Gabapentin Premedication to Reduce Postoperative Nausea and Vomiting in Surgical Patient Receiving Spinal Morphine[NCT02944981]	Phase 4	80 participants (Actual)	Interventional	2016-08-31	Completed
Comparison of Oral Gabapentin and Pregabalin in Postoperative Pain Control After Photorefractive Keratectomy: a Prospective, Randomized Study.[NCT00954187]		8 participants (Actual)	Interventional	2009-11-30	Terminated (stopped due to PI left institution)
The Impact of Perioperative Gabapentin on Chronic Groin Pain After Inguinal Hernia Repair[NCT02419443]	Phase 4	100 participants (Anticipated)	Interventional	2011-08-31	Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Surgical site pain. Scale 0-10, with 0 best and 10 worst (NCT03334903)
Timeframe: 2-3 months after surgery (at 2nd postoperative appointment)

"VAS Score 2: How Much Pain do You Feel in Your Operative Site When Moving?"

Intervention	score on 10-point scale (Mean)
Standard of Care	2.26
Postoperative Gabapentin Regimen	2.46

Surgical site pain. Scale 0-10, with 0 best and 10 worst. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

"VAS Score 3: How Well Are You Sleeping?"

Intervention	score on a 10-point scale (Mean)
Standard of Care	3.84
Postoperative Gabapentin Regimen	3.54

Sleep quality. Scale 0-10 with 0 worst and 10 best. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

"VAS Score 4: How Bad is Your Nausea?"

Intervention	score on a 10-point scale (Mean)
Standard of Care	5.73
Postoperative Gabapentin Regimen	6.38

Nausea. Scale 0-10, with 0 best and 10 worst. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

"VAS Score 5: How Satisfied Are You With Your Pain Management?"

Intervention	score on a 10-point scale (Mean)
Standard of Care	0.36
Postoperative Gabapentin Regimen	0.17

Satisfaction. Scale 0-10 with 0 worst and 10 best. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

Days Taking Opioids

Intervention	score on a 10-point scale (Mean)
Standard of Care	7.83
Postoperative Gabapentin Regimen	8.48

Number of days until patients are finished consuming opioid medications after discharge. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).

Opioid Consumption

Intervention	days (Mean)
Standard of Care	14.8
Postoperative Gabapentin Regimen	18.7

Mean opioid consumption, measured in mg of morphine equivalents. (NCT03334903)
Timeframe: 2-3 months following surgery (total amount measured at second postoperative appointment; means assessed afterwards).

Narcotic Use at 2 Weeks Postop

Intervention	morphine equivalents (Mean)
Standard of Care	287.0
Postoperative Gabapentin Regimen	281.1

Assessment of the amount of narcotic use postoperatively at 2 weeks. will use opioid equivalence table to convert all narcotic use to oxycodone equivalents (NCT02703259)
Timeframe: 2 weeks

Narcotic Use at 24 Hours Postop

Intervention	morphine milligram equivalents (Mean)
Gabapentin	167.2
Control	187.3

Assessment of the amount of narcotic use postoperatively at 24 hours. will use opioid equivalence table to convert all narcotic use to oxycodone equivalents (NCT02703259)
Timeframe: 24 hours

Subjective Pain at 2 Weeks Postop

Intervention	morphine milligram equivalents (Mean)
Gabapentin	158.8
Control	175.0

"Assessment of the subject pain score postoperatively at 2 weeks. will use a numeric analog scale from 0-10.~The pain scale ranging from 0-10 with 0 representing No Pain and 10 representing the Worst Pain Possible" (NCT02703259)
Timeframe: 2 weeks

Subjective Pain at 24 Hours Postoperative

Intervention	score on a scale (Mean)
Gabapentin	1.3
Control	1.4

Pain score assesses patient subjective pain via patient reported numeric analogue scale, range 0-10 with 0 being no pain and 10 being severe pain. (NCT02703259)
Timeframe: 24 hours

Number of Patient With Gabapentin Adverse Effects at 2 Weeks Postoperatively

Intervention	score on a scale (Mean)
Gabapentin	3.4
Control	3.4

Will assess for known symptoms of gabapentin postoperatively at 2 weeks. We will survey subjects regarding their experience of the following symptoms: dizziness/drowsiness, fatigue, loss of balance, blurry vision, tremulousness, swelling, nausea, vomiting, diarrhea, and allergic reaction (NCT02703259)
Timeframe: 2 weeks

Number of Patient With Gabapentin Adverse Effects at 24 Hours Postoperatively

Intervention	Participants (Count of Participants)
	Dizziness	Blurred vision	Somnolence	Difficulty walking	Tremulousness	Nausea	Vomiting
Control	8	3	21	5	2	7	1
Gabapentin	12	4	18	5	4	12	0

Will assess for known symptoms of gabapentin postoperatively at 24 hours. We will survey subjects regarding their experience of the following symptoms: dizziness/drowsiness, fatigue, loss of balance, blurry vision, tremulousness, swelling, nausea, vomiting, diarrhea, and allergic reaction (NCT02703259)
Timeframe: 24 hours

Total Morphine Consumption

NRS (Numerical Rating Scale)

Intervention	Participants (Count of Participants)
	Dizziness	Blurred Vision	Somnolence	Difficulty walking	Tremulousness	Nausea	Vomiting
Control	8	4	23	11	6	25	15
Gabapentin	17	7	20	13	11	24	9

Intervention	mg (Mean)
Gabapentin	14.3
Placebo	14.7

The NRS is a numerical scale ranging from 0-10 implemented with adults. Having no pain is rated as a 0 and the worst pain the patient could tolerate is rated as a 10. (NCT02359110)
Timeframe: 2-8 hours

VAS (Visual Analog Scale)

Intervention	units on a scale (Least Squares Mean)
	Hour 2	Hour 4	Hour 6	Hour 8
Gabapentin	3.5	5.4	5.3	5.7
Placebo	3.4	5.5	5.8	5.1

"The VAS is scored using a horizontal line 100mm in length. The scale is anchored by no pain (score of 0) and worst pain (score of 100)." (NCT02359110)
Timeframe: 2 -6 hours

ASES

Intervention	units on a scale (Least Squares Mean)
	Hour 2	Hour 6
Gabapentin	37.8	38.7
Placebo	33.9	36.9

American Shoulder and Elbow Surgeons (ASES) Shoulder Score for pain and function. Range 0-100. Low score = worse shoulder condition. Function, disability, and pain subscores (all ranges 0-50), and are summed for total ASES score. (NCT03540030)
Timeframe: 2 Weeks

Morphine Use

Intervention	units on a scale (Median)
Observational	54.3
Non-Opioid Intervention	54.2

Morphine milli-equivalents In-hospital post-operative. Continuous scale of MME, no defined better/worse. Measured as number and dose of medications taken. For example, if the patient received an opioid, the drug and dose was recorded and converted to MME. A time frame of when to assess opioid use in-hospital post-operative was not used but was a continuous monitor for rescue opioid from in-hospital post-operative through discharge. (NCT03540030)
Timeframe: In-hospital Stay

Post Op Pain

Intervention	Morphine milli-equivalents (Median)
Observational	45.0
Non-Opioid Intervention	19.0

Pain at patient discharge or 24-hours, whichever comes first - measured on a 0 (no pain) -10 (worst possible pain) numeric rating scale (NRS). A score of 0(no pain) is preferable to 10(worst possible pain) (NCT03540030)
Timeframe: 24 hours

Simple Shoulder Test

Intervention	score on a scale (Median)
Observational	3.0
Non-Opioid Intervention	2.0

Simple Shoulder Test (SST) activity score. Range 0-12. 0 = worse activity score. (NCT03540030)
Timeframe: 2 Months

Simple Shoulder Test

Intervention	score on a scale (Median)
Observational	6
Non-Opioid Intervention	6

Simple Shoulder Test (SST) activity score. Range 0-12. 0 = worse activity score. (NCT03540030)
Timeframe: 2 Weeks

Additional Post Op Pain

Intervention	score on a scale (Median)
Observational	2.0
Non-Opioid Intervention	2.0

post-operative pain: measured on a 0 (no pain) -10 (worst) numeric rating scale (NRS) at 6hrs, 12hrs, 2 weeks, and 2 months. A score of 0(no pain) is preferable to 10(worst possible pain) (NCT03540030)
Timeframe: 6hrs, 12hrs, 2weeks, 2 months

Constipation

Falls

Nausea

Pain Satisfaction

Intervention	score on a scale (Median)
	6 Hrs	12 hrs	2 weeks	2 months
Non-Opioid Intervention	0.0	0	0.82	0
Observational	2	4	1.3	0.7

Intervention	Participants (Count of Participants)
	Yes	No	Unknown
Non-Opioid Intervention	4	27	4
Observational	7	21	2

Intervention	Participants (Count of Participants)
	Yes	No	Unknown
Non-Opioid Intervention	13	22	0
Observational	19	9	2

Intervention	Participants (Count of Participants)
	Yes	No	Unknown
Non-Opioid Intervention	4	27	4
Observational	4	24	2

Intervention	Participants (Count of Participants)
	Yes	No	Unknown
Non-Opioid Intervention	5	30	0
Observational	1	27	2

Intervention	Participants (Count of Participants)
	Yes	No	Unknown
Non-Opioid Intervention	1	30	0
Observational	0	28	2

Intervention	Participants (Count of Participants)
	Yes	No	Unknown
Non-Opioid Intervention	1	34	0
Observational	5	23	2

Satisfaction with overall pain using Numeric Pain Rating (NRS) scale. yes, no. No being better than yes. (NCT03540030)
Timeframe: 2 Months

Pain Satisfaction

Intervention	Participants (Count of Participants)
	Yes	No	Unknown
Non-Opioid Intervention	29	2	4
Observational	23	5	2

Satisfaction with overall pain using Numeric Pain Rating (NRS) scale. yes, no. No being better than yes. (NCT03540030)
Timeframe: 2 Weeks

Veterans RAND 12 Item Health Survey (VR-12©) Physical Health Subscore, and Mental Health Subscore

Intervention	Participants (Count of Participants)
	Yes	No	Unknown
Non-Opioid Intervention	34	1	0
Observational	27	1	2

quality of life using VR-12 subscores. Physical Health (PCS) subscore and Mental Health (MCS) subscore, not summed. Range reported in weighted units. Physical Health subscore: 1 point increase in PCS is associated with 6% lower total health care expenditures, 5% lower pharmacy expenditures, 9% lower rate of hospital inpatient visits, 4% lower rate of medical provider visits, 5% lower rate of hospital outpatient visits. Mental Health sub score a 1 point increase in MCS is associated with 7% lower total health care expenditures, 4% lower pharmacy expenditures, 15% lower rate of hospital inpatient visits, and 4% lower rate of medical provider visits. Both PCS/MCS are score 0-100 with 100 indicating the highest level of health. (NCT03540030)
Timeframe: 2 Months

Veterans RAND 12 Item Health Survey (VR-12©) Physical Health Subscore, and Mental Health Subscore

Intervention	score on a scale (Median)
	PCS	MCS
Non-Opioid Intervention	40.3	60.8
Observational	38.4	58.7

Number of Patients With Hypoesthesia in the Anterior Chest at 3 Months After Operation.

Intervention	score on a scale (Median)
	PCS	MCS
Non-Opioid Intervention	35.0	59.1
Observational	36.7	56.3

we checked Hypoesthesia in the anterior chest at 3 months after operation by phone. (NCT00905580)
Timeframe: 3 months

Number of Patients Who Required Additional Analgesics During the First 48 Hours Postoperatively

Pain Scores (VNRS) at 1, 6, 24, 48 Hours Postoperatively.

Intervention	participants (Number)
Placebo	13
Pregabalin	10

Intervention	participants (Number)
	0-1 hour	1-6 hour	6 - 24 hour	24 - 48 hour
Placebo	31	17	15	7
Pregabalin	26	7	2	1

Pain was evaluated using an 11-point verbal numerical rating scale (VNRS). Patients were instructed preoperatively to express their pain on the 0-10 VNRS, where 0 means no pain at all, and 10 represents the worst pain imaginable (NCT00905580)
Timeframe: 1, 6, 24 & 48 hours

The Number of Participants With the Indicated Side Effects - Nausea & Vomiting, Sedation, Headache, Dizziness Etc.

Intervention	VNRS (Median)
	1 Hour	6 Hour	24 Hour	48 Hour
Placebo	6	3	2	2
Pregabalin	6	2	1	1

Nausea and vomiting was graded on a four-point scale, where 0 = no nausea, 1 = mild nausea, 2 = severe nausea requiring antiemetics, and 3 = retching and/ or vomiting. Grades 3 and 4 were grouped together as postoperative nausea and vomiting (PONV) and rescue anti-emetic, metoclopramide 10 mg i.v. was given. We asked patients about sedation, headache, dizziness, blurred vision. (NCT00905580)
Timeframe: 1, 6, 24 & 48 hours

Post-operative Opioid Consumption (mg/kg)

Intervention	participants (Number)
	PONV	headache	dizziness	sedation	blurred vision
Placebo	10	11	6	1	0
Pregabalin	7	8	14	6	3

Total amount of opioids consumed during the first 72 hours after surgery. (NCT02558010)
Timeframe: 72 hours

Difference in Pain Control When Adding Gabapentin to a Multimodal Pain Management Protocol in Pediatric Post-operative Posterior Spinal Fusion Patients.

Intervention	mg/kg (Median)
Methadone Group	0.267
Control Group	0.340

"Patients will rate their pain using the Visual Analog Pain Scale (VAS). The VAS is a 10 cm line with anchors of no pain and worst pain imaginable. Patients rate their pain by marking on the 10 cm line where they feel their pain is at the time. The mark is then measured according to where it is along the 10 cm line and reported (range is 0.0 at the no pain end on the left up to 10.0 at the worst pain imaginable on the right). Lower pain scores on the VAS scale are considered a better outcome. The numbers seen in the outcome measure data table below represent an average of the total postoperative VAS scores recorded for each patient from each arm for the duration of their hospital stay." (NCT01977937)
Timeframe: five days

Opiate Usage in the Gabapentin Group Versus Control.

Intervention	pain score on a scale (Mean)
Gabapentin	2.46
Simple Syrup	3.46

Total the amount of Hydromorphone and Oxycodone used in milligrams per kilogram in each patient post-operatively, convert this amount to morphine equivalents, and determine if there is a significant difference between the Gabapentin versus Placebo group. (NCT01977937)
Timeframe: Five Days

Narcotic Utilization

Intervention	morphine equivalents mg per kg (Mean)
Gabapentin	3.58
Simple Syrup	5.33

"total narcotic utilization measured with Morphine Milligram Equivalent (MME)~The conversion scale being used will be the Center for Disease Control and Prevention Morphine Equivalent Score.~Lower scores represent less opioid use and a better outcome. Higher scores represent more opioid use and a worse outcome." (NCT03330119)
Timeframe: From time of consent until hospital discharge (3 days)

Time to First Analgesia

Intervention	MME (Mean)
Alternate Management	33.3
Control	47.2

Time to first analgesia is recorded from IV PCA. (NCT02285010)
Timeframe: 24 hours

Pain Scores on the Visual Analog Scale

Intervention	hour (Median)
Placebo	4.6
Pregabalin	7.7

"Pain score is evaluated by nurses using Numerical Rating Scale (NRS)~Minimum score 0 (no pain), Maximum score 10 (worst imaginable pain), lower scores mean a better outcome" (NCT02285010)
Timeframe: 24 hours

Post Operative Morphine Consumption

Intervention	score on a scale (Median)
	At rest	At movement
Placebo	2	4
Pregabalin	2	4

Cumulative morphine consumption in the first 24 hours is recorded from IV PCA (NCT02285010)
Timeframe: 6, 12, and 24 hours after operation

Numbers of Participants With Adverse Events as a Measure of Safety and Tolerability

Intervention	mg (Median)
	Morphine consumption 6 hr	Morphine consumption 12 hr	Morphine consumption 24 hr
Placebo	1	1	4
Pregabalin	0	1	5

Measure sedation score by evaluate and observe; measure pruritus, PONV, dizziness, visual disturbance using questionnaire (NCT02285010)
Timeframe: 24 hours

Difference in Psychological Outcomes on the Sickness Inventory Profile (SIP)

Intervention	Participants (Count of Participants)
	Pruritus72177998	Pruritus72177999	Nausea72177998	Nausea72177999	Vomiting72177998	Vomiting72177999	Dizziness72177998	Dizziness72177999	Visual disturbance72177998	Visual disturbance72177999
	No	Mild	Moderate	Severe
Pregabalin	17
Placebo	35
Pregabalin	31
Placebo	15
Pregabalin	10
Placebo	1
Pregabalin	3
Placebo	18
Pregabalin	23
Placebo	24
Pregabalin	21
Placebo	16
Placebo	31
Pregabalin	38
Placebo	10
Pregabalin	9
Placebo	12
Pregabalin	8
Placebo	5
Pregabalin	6
Pregabalin	14
Pregabalin	39
Placebo	9
Pregabalin	7
Pregabalin	1
Placebo	51
Pregabalin	45
Placebo	7
Pregabalin	16
Placebo	0
Pregabalin	0

The sickness inventory profile (SIP) is a behaviorally based measure of health status. Scores range from 0-68 with higher numbers indicating worse outcomes. The study report total SIP score. The higher the score the worse the function. (NCT01265056)
Timeframe: First Clinic Follow Up After Discharge

Opioid Consumption Between the Treatment and the Control Groups (Morphine Equivalents)

Intervention	units on a scale (Mean)
Placebo	34.9
Gabapentin	36.0

(NCT01265056)
Timeframe: From time of enrollment to 2 weeks after being discharged

Psychological Functioning as Evaluated by the Brief Symptom Inventory (BSI) Between Treatment and Placebo Groups

Intervention	morphine equivalents (Mean)
Placebo	7.0
Gabapentin	6.7

The Brief Symptom Inventory 18 (BSI 18) is designed with reliability in mind. The BSI 18 assessment gathers patient-reported data to help measure psychological distress and psychiatric disorders in medical and community populations. As the latest in an integrated series of test instruments that include the SCL-90-R®, BSI® (53 questions), and DPRS® instruments, the BSI 18 test offers a more effective, easy-to-administer tool to help support clinical decision-making and monitor progress throughout treatment. BSI-18 measures three dimensions with 6 questions a piece (somatization , depression , anxiety) and overall psychological distress scores (Global severity index, GSI). Each of the 18 items range from a score of 0-4; total score ranges from 0-72 with higher scores indicating worse function. The GSI score is calculated as the mean of the three subscales. The study reported the GSI score. Higher score is worse. (NCT01265056)
Timeframe: First Clinic Follow Up After Discharge

Evaluate Incidence of Respiratory Depression as Evidenced by Pulse Oximetry Data

Evaluate the Amount of Diluadid Given Postoperatively

The amount of intraoperative and postoperative opioids used will be collected and analyzed for the three different arms. (NCT00886236)
Timeframe: 120 hours

Number of Participants Who Experience Incidence of Postoperative Nausea.

Reviews

10 reviews available for gamma-aminobutyric acid and Postoperative Nausea and Vomiting

Trials

33 trials available for gamma-aminobutyric acid and Postoperative Nausea and Vomiting

Other Studies

5 other studies available for gamma-aminobutyric acid and Postoperative Nausea and Vomiting

Intervention	% oxygen saturation (Mean)
1 Preoperative Gabapentin Liquid	93
2 Preoperative and Postoperative Gabapentin Liquid	94
3 Preoperative and Postoperative Placebo Liquid	95

Intervention	ml (Mean)
1 Preoperative Gabapentin Liquid	11.035
2 Preoperative and Postoperative Gabapentin Liquid	8.7
3 Preoperative and Postoperative Placebo Liquid	12.4

Article	Year
Is gabapentin effective and safe in open hysterectomy? A PRISMA compliant meta-analysis of randomized controlled trials. Journal of clinical anesthesia, 2017, Volume: 41 Topics: Amines; Analgesia; Analgesics; Analgesics, Opioid; Cyclohexanecarboxylic Acids; Female; Gabapentin;	2017
The efficacy of gabapentin in reducing pain intensity and postoperative nausea and vomiting following laparoscopic cholecystectomy: A meta-analysis. Medicine, 2017, Volume: 96, Issue:37 Topics: Amines; Analgesics; Cholecystectomy, Laparoscopic; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Am	2017
The Efficacy of Preoperative Gabapentin in Spinal Surgery: A Meta-Analysis of Randomized Controlled Trials. Pain physician, 2017, Volume: 20, Issue:7 Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; Pain M	2017
['Postoperative pain treatment' practice guideline revised]. Nederlands tijdschrift voor geneeskunde, 2013, Volume: 157, Issue:49 Topics: Adult; Amines; Analgesia, Epidural; Child; Cyclohexanecarboxylic Acids; Dexamethasone; Gabapentin; g	2013
Preemptive use of gabapentin in abdominal hysterectomy: a systematic review and meta-analysis. Obstetrics and gynecology, 2014, Volume: 123, Issue:6 Topics: Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobut	2014
Preemptive use of gabapentin in abdominal hysterectomy: a systematic review and meta-analysis. Obstetrics and gynecology, 2014, Volume: 123, Issue:6 Topics: Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobut	2014
Preemptive use of gabapentin in abdominal hysterectomy: a systematic review and meta-analysis. Obstetrics and gynecology, 2014, Volume: 123, Issue:6 Topics: Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobut	2014
Preemptive use of gabapentin in abdominal hysterectomy: a systematic review and meta-analysis. Obstetrics and gynecology, 2014, Volume: 123, Issue:6 Topics: Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobut	2014
Preemptive use of gabapentin in abdominal hysterectomy: a systematic review and meta-analysis. Obstetrics and gynecology, 2014, Volume: 123, Issue:6 Topics: Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobut	2014
Preemptive use of gabapentin in abdominal hysterectomy: a systematic review and meta-analysis. Obstetrics and gynecology, 2014, Volume: 123, Issue:6 Topics: Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobut	2014
Preemptive use of gabapentin in abdominal hysterectomy: a systematic review and meta-analysis. Obstetrics and gynecology, 2014, Volume: 123, Issue:6 Topics: Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobut	2014
Preemptive use of gabapentin in abdominal hysterectomy: a systematic review and meta-analysis. Obstetrics and gynecology, 2014, Volume: 123, Issue:6 Topics: Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobut	2014
Preemptive use of gabapentin in abdominal hysterectomy: a systematic review and meta-analysis. Obstetrics and gynecology, 2014, Volume: 123, Issue:6 Topics: Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobut	2014
Gabapentin prophylaxis for postoperative nausea and vomiting in abdominal surgeries: a quantitative analysis of evidence from randomized controlled clinical trials. British journal of anaesthesia, 2015, Volume: 114, Issue:4 Topics: Abdomen; Amines; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; Postopera	2015
A systematic review and meta-regression analysis of prophylactic gabapentin for postoperative pain. Anaesthesia, 2015, Volume: 70, Issue:10 Topics: Amines; Analgesics; Analgesics, Opioid; Cyclohexanecarboxylic Acids; Drug Administration Schedule; D	2015
A systematic review and meta-regression analysis of prophylactic gabapentin for postoperative pain. Anaesthesia, 2015, Volume: 70, Issue:10 Topics: Amines; Analgesics; Analgesics, Opioid; Cyclohexanecarboxylic Acids; Drug Administration Schedule; D	2015
A systematic review and meta-regression analysis of prophylactic gabapentin for postoperative pain. Anaesthesia, 2015, Volume: 70, Issue:10 Topics: Amines; Analgesics; Analgesics, Opioid; Cyclohexanecarboxylic Acids; Drug Administration Schedule; D	2015
A systematic review and meta-regression analysis of prophylactic gabapentin for postoperative pain. Anaesthesia, 2015, Volume: 70, Issue:10 Topics: Amines; Analgesics; Analgesics, Opioid; Cyclohexanecarboxylic Acids; Drug Administration Schedule; D	2015
The Effect of Preoperative Gabapentin on Postoperative Nausea and Vomiting: A Meta-Analysis. Anesthesia and analgesia, 2016, Volume: 122, Issue:4 Topics: Amines; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; Postoperative Naus	2016
The Effect of Preoperative Gabapentin on Postoperative Nausea and Vomiting: A Meta-Analysis. Anesthesia and analgesia, 2016, Volume: 122, Issue:4 Topics: Amines; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; Postoperative Naus	2016
The Effect of Preoperative Gabapentin on Postoperative Nausea and Vomiting: A Meta-Analysis. Anesthesia and analgesia, 2016, Volume: 122, Issue:4 Topics: Amines; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; Postoperative Naus	2016
The Effect of Preoperative Gabapentin on Postoperative Nausea and Vomiting: A Meta-Analysis. Anesthesia and analgesia, 2016, Volume: 122, Issue:4 Topics: Amines; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; Postoperative Naus	2016
Efficacy and safety of perioperative pregabalin for post-operative pain: a meta-analysis of randomized-controlled trials. Acta anaesthesiologica Scandinavica, 2011, Volume: 55, Issue:8 Topics: Analgesics; Analgesics, Opioid; Confusion; Dizziness; Dose-Response Relationship, Drug; Endpoint Det	2011
Gabapentin: a multimodal perioperative drug? British journal of anaesthesia, 2007, Volume: 99, Issue:6 Topics: Amines; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Blood Pressure; Chronic Disease; Cyclohexanec	2007
Gabapentin: a multimodal perioperative drug? British journal of anaesthesia, 2007, Volume: 99, Issue:6 Topics: Amines; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Blood Pressure; Chronic Disease; Cyclohexanec	2007
Gabapentin: a multimodal perioperative drug? British journal of anaesthesia, 2007, Volume: 99, Issue:6 Topics: Amines; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Blood Pressure; Chronic Disease; Cyclohexanec	2007
Gabapentin: a multimodal perioperative drug? British journal of anaesthesia, 2007, Volume: 99, Issue:6 Topics: Amines; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Blood Pressure; Chronic Disease; Cyclohexanec	2007
Gabapentin: a multimodal perioperative drug? British journal of anaesthesia, 2007, Volume: 99, Issue:6 Topics: Amines; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Blood Pressure; Chronic Disease; Cyclohexanec	2007
Gabapentin: a multimodal perioperative drug? British journal of anaesthesia, 2007, Volume: 99, Issue:6 Topics: Amines; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Blood Pressure; Chronic Disease; Cyclohexanec	2007
Gabapentin: a multimodal perioperative drug? British journal of anaesthesia, 2007, Volume: 99, Issue:6 Topics: Amines; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Blood Pressure; Chronic Disease; Cyclohexanec	2007
Gabapentin: a multimodal perioperative drug? British journal of anaesthesia, 2007, Volume: 99, Issue:6 Topics: Amines; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Blood Pressure; Chronic Disease; Cyclohexanec	2007
Gabapentin: a multimodal perioperative drug? British journal of anaesthesia, 2007, Volume: 99, Issue:6 Topics: Amines; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Blood Pressure; Chronic Disease; Cyclohexanec	2007

Article	Year
Gabapentin for Postoperative Vomiting in Children Requiring Posterior Fossa Tumor Resection. Pediatrics and neonatology, 2015, Volume: 56, Issue:5 Topics: Amines; Cerebellar Neoplasms; Child; Child, Preschool; Craniotomy; Cyclohexanecarboxylic Acids; Exci	2015
Utilization of a Preemptive, Multimodal Analgesic Regimen in Adult Ambulatory Septoplasty Patients: A Quality Improvement Project. ORL-head and neck nursing : official journal of the Society of Otorhinolaryngology and Head-Neck Nurses, 2015,Autumn, Volume: 33, Issue:4 Topics: Acetaminophen; Adult; Ambulatory Surgical Procedures; Amines; Analgesics; Celecoxib; Cyclohexanecarb	2015
[Postoperative inconveniences after breast cancer surgery]. Ugeskrift for laeger, 2008, Jun-02, Volume: 170, Issue:23 Topics: Acetaminophen; Amines; Analgesics; Antiemetics; Antitussive Agents; Breast Neoplasms; Celecoxib; Cyc	2008
[Multimodal treatment of pain and nausea in breast cancer surgery]. Ugeskrift for laeger, 2008, Jun-02, Volume: 170, Issue:23 Topics: Adult; Aged; Aged, 80 and over; Amines; Analgesics; Antiemetics; Antitussive Agents; Breast Neoplasm	2008
Need for improved treatment of postoperative pain. Danish medical journal, 2012, Volume: 59, Issue:4 Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Amines; Analgesics; Analgesics, Opioid; A	2012