gamma-aminobutyric acid has been researched along with Peripheral Nerve Injuries in 48 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
Peripheral Nerve Injuries: Injuries to the PERIPHERAL NERVES.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The effects of genistein were compared with those of gabapentin, which is widely used in clinical practice for peripheral nerve injury." | 7.85 | Neuroprotective Effect of Genistein in Peripheral Nerve Injury. ( Arslantas, A; Aydin, HE; Baycu, C; Bektur, E; Kocman, AE; Kose, A; Ozbek, Z; Ozkara, E; Sahin, E; Vural, M, 2017) |
| "Genistein and gabapentin exhibit positive effects on histopathology, inflammation, and clinical findings of peripheral nerve injury." | 7.85 | Neuroprotective Effect of Genistein in Peripheral Nerve Injury. ( Arslantas, A; Aydin, HE; Baycu, C; Bektur, E; Kocman, AE; Kose, A; Ozbek, Z; Ozkara, E; Sahin, E; Vural, M, 2017) |
| " Because peripheral nerve lesions are a major cause of chronic pain after surgery, we tested in rats whether analgesic treatment with pregabalin (PGB) has the capacity to mitigate the development of persistent neuropathic pain-like behavior." | 7.80 | Analgesic treatment with pregabalin does not prevent persistent pain after peripheral nerve injury in the rat. ( Derry, WT; Scholz, J; Vardeh, D; Whang, J; Yang, F, 2014) |
| "These results suggest that peripheral nerve injury induces plasticity of GABAergic neurons differently in the LC and spinal dorsal horn and that gabapentin reduces presynaptic GABA release in the LC but not in the spinal dorsal horn." | 7.78 | Gabapentin inhibits γ-amino butyric acid release in the locus coeruleus but not in the spinal dorsal horn after peripheral nerve injury in rats. ( Eisenach, JC; Hayashida, K; Parker, RA; Yoshizumi, M, 2012) |
| "Although gabapentin may relieve neuropathic pain by actions at many sites, these results suggest that its actions in the brain to cause spinal cholinergic activation predominate after oral administration." | 7.74 | Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil. ( Eisenach, JC; Hayashida, K; Parker, R, 2007) |
| "Systemic gabapentin, commonly used to treat chronic pain, impaired the novel object recognition task in normal but not SNL animals." | 5.40 | Peripheral nerve injury and gabapentin, but not their combination, impair attentional behavior via direct effects on noradrenergic signaling in the brain. ( Eisenach, JC; Hayashida, K; Suto, T, 2014) |
| "A double-blind, randomized, placebo-controlled cross-over multi-center study was conducted to evaluate the efficacy and safety of gabapentin in the treatment of neuropathic pain caused by traumatic or postsurgical peripheral nerve injury, using doses up to 2400 mg/day." | 5.13 | Gabapentin in traumatic nerve injury pain: a randomized, double-blind, placebo-controlled, cross-over, multi-center study. ( Arnèr, S; Biber, B; Boivie, J; Gordh, TE; Jensen, TS; Kalliomäki, J; Kalso, E; Mannheimer, C; Stubhaug, A, 2008) |
| " The effects of genistein were compared with those of gabapentin, which is widely used in clinical practice for peripheral nerve injury." | 3.85 | Neuroprotective Effect of Genistein in Peripheral Nerve Injury. ( Arslantas, A; Aydin, HE; Baycu, C; Bektur, E; Kocman, AE; Kose, A; Ozbek, Z; Ozkara, E; Sahin, E; Vural, M, 2017) |
| "Genistein and gabapentin exhibit positive effects on histopathology, inflammation, and clinical findings of peripheral nerve injury." | 3.85 | Neuroprotective Effect of Genistein in Peripheral Nerve Injury. ( Arslantas, A; Aydin, HE; Baycu, C; Bektur, E; Kocman, AE; Kose, A; Ozbek, Z; Ozkara, E; Sahin, E; Vural, M, 2017) |
| " Because peripheral nerve lesions are a major cause of chronic pain after surgery, we tested in rats whether analgesic treatment with pregabalin (PGB) has the capacity to mitigate the development of persistent neuropathic pain-like behavior." | 3.80 | Analgesic treatment with pregabalin does not prevent persistent pain after peripheral nerve injury in the rat. ( Derry, WT; Scholz, J; Vardeh, D; Whang, J; Yang, F, 2014) |
| "These results suggest that peripheral nerve injury induces plasticity of GABAergic neurons differently in the LC and spinal dorsal horn and that gabapentin reduces presynaptic GABA release in the LC but not in the spinal dorsal horn." | 3.78 | Gabapentin inhibits γ-amino butyric acid release in the locus coeruleus but not in the spinal dorsal horn after peripheral nerve injury in rats. ( Eisenach, JC; Hayashida, K; Parker, RA; Yoshizumi, M, 2012) |
| "Although gabapentin may relieve neuropathic pain by actions at many sites, these results suggest that its actions in the brain to cause spinal cholinergic activation predominate after oral administration." | 3.74 | Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil. ( Eisenach, JC; Hayashida, K; Parker, R, 2007) |
| " In the current study, we evaluated the behavioral effects of two standard drugs used clinically for neuropathic pain, the anticonvulsant gabapentin and antidepressant imipramine, in rats at different times after peripheral nerve injury." | 3.73 | The effect of antinociceptive drugs tested at different times after nerve injury in rats. ( Borsook, D; Hama, AT, 2005) |
| "Gabapentin was well tolerated." | 2.73 | Gabapentin in traumatic nerve injury pain: a randomized, double-blind, placebo-controlled, cross-over, multi-center study. ( Arnèr, S; Biber, B; Boivie, J; Gordh, TE; Jensen, TS; Kalliomäki, J; Kalso, E; Mannheimer, C; Stubhaug, A, 2008) |
| "Chronic pain affects quality of life and adversely affects functional outcomes." | 2.49 | Management of chronic pain following nerve injuries/CRPS type II. ( Carroll, I; Curtin, CM, 2013) |
| "There is much information on chronic pain and its treatment, but it is often published outside of surgery and diffusion of this information across disciplines is slow." | 2.49 | Management of chronic pain following nerve injuries/CRPS type II. ( Carroll, I; Curtin, CM, 2013) |
| "Peripheral nerve injury affects motor functions." | 1.72 | Slow progression of sciatic nerve degeneration and regeneration after loose ligation through microglial activation and decreased KCC2 levels in the mouse spinal cord ventral horn. ( Kim, J; Kinjo, D; Kobayashi, S; Kosaka, Y; Matsuda, K; Okabe, A; Okura, N; Shimizu-Okabe, C; Takayama, C; Yafuso, T, 2022) |
| "Development of chronic pain has been attributed to dysfunctional GABA signaling in the spinal cord." | 1.72 | Analgesic effect of recombinant GABAergic precursors releasing ω-conotoxin MVIIA in a model of peripheral nerve injury in rats. ( Hernandez, M; Jergova, S; Sagen, J, 2022) |
| "A cardinal, intractable symptom of neuropathic pain is mechanical allodynia, pain caused by innocuous stimuli via low-threshold mechanoreceptors such as Aβ fibers." | 1.62 | A subset of spinal dorsal horn interneurons crucial for gating touch-evoked pain-like behavior. ( Furue, H; Koga, K; Sekine, M; Tashima, R; Tozaki-Saitoh, H; Tsuda, M; Watanabe, M; Yasaka, T; Yoshikawa, Y, 2021) |
| "The gliosis was associated with the reduction of glial aminoacid transporters (GLT1 and GlyT1) and increase of neuronal glutamate transporter EAAC1." | 1.43 | Astrocytes and Microglia-Mediated Immune Response in Maladaptive Plasticity is Differently Modulated by NGF in the Ventral Horn of the Spinal Cord Following Peripheral Nerve Injury. ( Alberghina, L; Bianco, MR; Cirillo, G; Colangelo, AM; De Luca, C; Papa, M; Savarese, L, 2016) |
| "In the nerve injury model of neuropathic pain, WNK1/HSN2 contributed to a maladaptive decrease in the activity of the K(+)-Cl(-)cotransporter KCC2 by increasing its inhibitory phosphorylation at Thr(906)and Thr(1007), resulting in an associated loss of GABA (γ-aminobutyric acid)-mediated inhibition of spinal pain-transmitting nerves." | 1.43 | Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition. ( Andrews, N; Castonguay, G; Dion, PA; Duan, J; Gaudet, R; Hince, P; Inquimbert, P; Kahle, KT; Khanna, AR; Laganière, J; Latremoliere, A; Lavastre, V; Mapplebeck, JC; Mogil, JS; Omura, T; Rochefort, D; Rouleau, GA; Schmouth, JF; Sotocinal, SG; Ward, C; Woolf, CJ; Zhang, J, 2016) |
| "In addition, PLSN-induced mechanical and thermal hyperalgesia was prevented by systemic (i." | 1.40 | The role of keratinocyte-derived chemokine (KC) on hyperalgesia caused by peripheral nerve injury in mice. ( Calixto, JB; Costa, R; Manjavachi, MN; Quintão, NL, 2014) |
| "Systemic gabapentin, commonly used to treat chronic pain, impaired the novel object recognition task in normal but not SNL animals." | 1.40 | Peripheral nerve injury and gabapentin, but not their combination, impair attentional behavior via direct effects on noradrenergic signaling in the brain. ( Eisenach, JC; Hayashida, K; Suto, T, 2014) |
| "The selected neuropathic pain model was the spared nerve injury (SNI) model and the endpoints were burrowing and measures of paw posture in Sprague Dawley rats." | 1.39 | A back translation of pregabalin and carbamazepine against evoked and non-evoked endpoints in the rat spared nerve injury model of neuropathic pain. ( de Lannoy, IA; Dykstra, C; Higgins, GA; Lau, W; Lee, DK; Silenieks, LB; Thevarkunnel, S, 2013) |
| "Animal models of neuropathic pain have enabled the identification of key pathophysiological changes occurring within nociceptive pathways as a result of injury, and serve an invaluable role for preclinical screening of novel analgesic candidates." | 1.34 | The importance of genetic background on pain behaviours and pharmacological sensitivity in the rat spared serve injury model of peripheral neuropathic pain. ( Bjerrum, OJ; Blackburn-Munro, G; Broløs, T; Jensen, DG; Rode, F; Thomsen, M, 2007) |
| "Mechanical allodynia was maximal by 1 week and persisted at blunted levels for at least 18 weeks after injury." | 1.33 | Spinal nerve ligation does not alter the expression or function of GABA(B) receptors in spinal cord and dorsal root ganglia of the rat. ( Bettler, B; Engle, MP; Gassman, M; Hammond, DL; Sykes, KT, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.08) | 18.7374 |
| 1990's | 3 (6.25) | 18.2507 |
| 2000's | 13 (27.08) | 29.6817 |
| 2010's | 27 (56.25) | 24.3611 |
| 2020's | 4 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Yafuso, T | 1 |
| Kosaka, Y | 1 |
| Shimizu-Okabe, C | 1 |
| Okura, N | 1 |
| Kobayashi, S | 1 |
| Kim, J | 1 |
| Matsuda, K | 1 |
| Kinjo, D | 1 |
| Okabe, A | 1 |
| Takayama, C | 1 |
| Jergova, S | 1 |
| Hernandez, M | 1 |
| Sagen, J | 2 |
| Medeiros, P | 1 |
| de Freitas, RL | 1 |
| Boccella, S | 1 |
| Iannotta, M | 1 |
| Belardo, C | 1 |
| Mazzitelli, M | 1 |
| Romano, R | 1 |
| De Gregorio, D | 1 |
| Coimbra, NC | 1 |
| Palazzo, E | 1 |
| Maione, S | 1 |
| Tashima, R | 1 |
| Koga, K | 1 |
| Yoshikawa, Y | 1 |
| Sekine, M | 1 |
| Watanabe, M | 1 |
| Tozaki-Saitoh, H | 1 |
| Furue, H | 1 |
| Yasaka, T | 1 |
| Tsuda, M | 1 |
| Inquimbert, P | 2 |
| Moll, M | 1 |
| Latremoliere, A | 2 |
| Tong, CK | 1 |
| Whang, J | 2 |
| Sheehan, GF | 1 |
| Smith, BM | 1 |
| Korb, E | 1 |
| Athié, MCP | 1 |
| Babaniyi, O | 1 |
| Ghasemlou, N | 1 |
| Yanagawa, Y | 1 |
| Allis, CD | 1 |
| Hof, PR | 1 |
| Scholz, J | 2 |
| Hayashida, KI | 2 |
| Eisenach, JC | 8 |
| Kawatani, M | 1 |
| Martin, TJ | 2 |
| Khuong, TM | 1 |
| Wang, QP | 1 |
| Manion, J | 1 |
| Oyston, LJ | 1 |
| Lau, MT | 1 |
| Towler, H | 1 |
| Lin, YQ | 1 |
| Neely, GG | 1 |
| Lau, W | 1 |
| Dykstra, C | 1 |
| Thevarkunnel, S | 1 |
| Silenieks, LB | 1 |
| de Lannoy, IA | 1 |
| Lee, DK | 1 |
| Higgins, GA | 1 |
| Carroll, I | 1 |
| Curtin, CM | 1 |
| Yang, F | 1 |
| Derry, WT | 1 |
| Vardeh, D | 1 |
| Manjavachi, MN | 1 |
| Costa, R | 1 |
| Quintão, NL | 1 |
| Calixto, JB | 1 |
| Dickenson, AH | 2 |
| Kehlet, H | 1 |
| Lana, B | 1 |
| Schlick, B | 1 |
| Martin, S | 1 |
| Pratt, WS | 1 |
| Page, KM | 1 |
| Goncalves, L | 1 |
| Rahman, W | 1 |
| Bauer, CS | 1 |
| Dolphin, AC | 1 |
| Suto, T | 1 |
| Hayashida, K | 5 |
| Shen, X | 1 |
| Liu, Y | 1 |
| Xu, S | 1 |
| Zhao, Q | 1 |
| Wu, H | 1 |
| Guo, X | 1 |
| Shen, R | 1 |
| Wang, F | 1 |
| Berrocoso, E | 1 |
| Miranda, HF | 1 |
| Noriega, V | 1 |
| Zepeda, R | 1 |
| Zanetta, P | 1 |
| Prieto-Rayo, J | 1 |
| Prieto, JC | 1 |
| Sierralta, F | 1 |
| Todd, AJ | 1 |
| Griggs, RB | 1 |
| Bardo, MT | 1 |
| Taylor, BK | 1 |
| De Luca, C | 2 |
| Savarese, L | 2 |
| Colangelo, AM | 2 |
| Bianco, MR | 1 |
| Cirillo, G | 2 |
| Alberghina, L | 2 |
| Papa, M | 2 |
| Kahle, KT | 1 |
| Schmouth, JF | 1 |
| Lavastre, V | 1 |
| Zhang, J | 1 |
| Andrews, N | 2 |
| Omura, T | 1 |
| Laganière, J | 1 |
| Rochefort, D | 1 |
| Hince, P | 1 |
| Castonguay, G | 1 |
| Gaudet, R | 1 |
| Mapplebeck, JC | 1 |
| Sotocinal, SG | 1 |
| Duan, J | 1 |
| Ward, C | 1 |
| Khanna, AR | 1 |
| Mogil, JS | 1 |
| Dion, PA | 1 |
| Woolf, CJ | 1 |
| Rouleau, GA | 1 |
| Barillari, MR | 1 |
| Iura, A | 1 |
| Takahashi, A | 1 |
| Hakata, S | 1 |
| Mashimo, T | 1 |
| Fujino, Y | 1 |
| Kimura, M | 3 |
| Ozbek, Z | 1 |
| Aydin, HE | 1 |
| Kocman, AE | 1 |
| Ozkara, E | 1 |
| Sahin, E | 1 |
| Bektur, E | 1 |
| Vural, M | 1 |
| Kose, A | 1 |
| Arslantas, A | 1 |
| Baycu, C | 1 |
| Tanabe, M | 1 |
| Takasu, K | 1 |
| Takeuchi, Y | 1 |
| Ono, H | 1 |
| Rudomin, P | 1 |
| Böhm, J | 1 |
| Visser, LH | 1 |
| Lehmann, TN | 1 |
| Ewan, EE | 1 |
| Legg, E | 1 |
| Lisak, D | 1 |
| Issop, Y | 1 |
| Richardson, D | 1 |
| Harper, S | 1 |
| Pheby, T | 1 |
| Huang, W | 1 |
| Burgess, G | 1 |
| Machin, I | 1 |
| Rice, AS | 1 |
| Yoshizumi, M | 2 |
| Parker, RA | 1 |
| Hobo, S | 1 |
| Obata, H | 2 |
| Saito, S | 1 |
| Staley, K | 1 |
| Lever, I | 1 |
| Cunningham, J | 1 |
| Grist, J | 1 |
| Yip, PK | 1 |
| Malcangio, M | 1 |
| Wu, WP | 1 |
| Hao, JX | 1 |
| Ongini, E | 1 |
| Impagnatiello, F | 1 |
| Presotto, C | 1 |
| Wiesenfeld-Hallin, Z | 1 |
| Xu, XJ | 1 |
| Hama, AT | 3 |
| Borsook, D | 2 |
| Engle, MP | 1 |
| Gassman, M | 1 |
| Sykes, KT | 1 |
| Bettler, B | 1 |
| Hammond, DL | 1 |
| Garraghty, PE | 2 |
| Arnold, LL | 1 |
| Wellman, CL | 1 |
| Mowery, TM | 1 |
| Rode, F | 1 |
| Thomsen, M | 1 |
| Broløs, T | 1 |
| Jensen, DG | 1 |
| Blackburn-Munro, G | 1 |
| Bjerrum, OJ | 1 |
| Yogeeswari, P | 1 |
| Ragavendran, JV | 1 |
| Sriram, D | 1 |
| Nageswari, Y | 1 |
| Kavya, R | 1 |
| Sreevatsan, N | 1 |
| Vanitha, K | 1 |
| Stables, J | 1 |
| Parker, R | 1 |
| Gordh, TE | 1 |
| Stubhaug, A | 1 |
| Jensen, TS | 1 |
| Arnèr, S | 1 |
| Biber, B | 1 |
| Boivie, J | 1 |
| Mannheimer, C | 1 |
| Kalliomäki, J | 1 |
| Kalso, E | 1 |
| Ibuki, T | 1 |
| Wang, XT | 1 |
| Pappas, GD | 1 |
| Pan, HL | 1 |
| Chen, SR | 1 |
| LaChica, EA | 1 |
| Kaas, JH | 1 |
| Somps, CJ | 1 |
| Boyajian, CL | 1 |
| Luttges, MW | 1 |
4 reviews available for gamma-aminobutyric acid and Peripheral Nerve Injuries
| Article | Year |
|---|---|
Management of chronic pain following nerve injuries/CRPS type II.
Topics: Amines; Antidepressive Agents, Tricyclic; Calcium Channel Blockers; Capsaicin; Causalgia; Chronic Pa | 2013 |
Plasticity of inhibition in the spinal cord.
Topics: Animals; gamma-Aminobutyric Acid; Humans; Interneurons; Neural Inhibition; Neuronal Plasticity; Pain | 2015 |
Pain relief by gabapentin and pregabalin via supraspinal mechanisms after peripheral nerve injury.
Topics: Amines; Analgesics; Animals; Brain; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid | 2008 |
In search of lost presynaptic inhibition.
Topics: Animals; gamma-Aminobutyric Acid; Humans; Interneurons; Muscles; Neural Inhibition; Neuronal Plastic | 2009 |
1 trial available for gamma-aminobutyric acid and Peripheral Nerve Injuries
| Article | Year |
|---|---|
Gabapentin in traumatic nerve injury pain: a randomized, double-blind, placebo-controlled, cross-over, multi-center study.
Topics: Adult; Aged; Aged, 80 and over; Amines; Cross-Over Studies; Cyclohexanecarboxylic Acids; Double-Blin | 2008 |
43 other studies available for gamma-aminobutyric acid and Peripheral Nerve Injuries
| Article | Year |
|---|---|
Slow progression of sciatic nerve degeneration and regeneration after loose ligation through microglial activation and decreased KCC2 levels in the mouse spinal cord ventral horn.
Topics: Animals; Choline O-Acetyltransferase; gamma-Aminobutyric Acid; Glycine; K Cl- Cotransporters; Mice; | 2022 |
Analgesic effect of recombinant GABAergic precursors releasing ω-conotoxin MVIIA in a model of peripheral nerve injury in rats.
Topics: Analgesics; Animals; Chronic Pain; Cytokines; gamma-Aminobutyric Acid; omega-Conotoxins; Peptides; P | 2022 |
Characterization of the sensory, affective, cognitive, biochemical, and neuronal alterations in a modified chronic constriction injury model of neuropathic pain in mice.
Topics: Animals; Aspartic Acid; Behavior, Animal; Brain; Cognition; gamma-Aminobutyric Acid; Male; Mice; Neu | 2020 |
A subset of spinal dorsal horn interneurons crucial for gating touch-evoked pain-like behavior.
Topics: Animals; gamma-Aminobutyric Acid; Hyperalgesia; Interneurons; Male; Mechanoreceptors; Neuralgia; Noc | 2021 |
NMDA Receptor Activation Underlies the Loss of Spinal Dorsal Horn Neurons and the Transition to Persistent Pain after Peripheral Nerve Injury.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cell Survival; Chronic Pain; Down-Regulation; gamma- | 2018 |
Peripheral nerve injury in rats induces alternations in choice behavior associated with food reinforcement.
Topics: Animals; Choice Behavior; Disease Models, Animal; Food; gamma-Aminobutyric Acid; Hyperalgesia; Ligat | 2019 |
Nerve injury drives a heightened state of vigilance and neuropathic sensitization in
Topics: Animals; Arousal; Biomarkers; Cell Death; Drosophila; GABAergic Neurons; gamma-Aminobutyric Acid; Hy | 2019 |
A back translation of pregabalin and carbamazepine against evoked and non-evoked endpoints in the rat spared nerve injury model of neuropathic pain.
Topics: Animals; Behavior, Animal; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; | 2013 |
Analgesic treatment with pregabalin does not prevent persistent pain after peripheral nerve injury in the rat.
Topics: Analgesics; Animals; Chronic Pain; gamma-Aminobutyric Acid; Injections, Spinal; Male; Pain Measureme | 2014 |
The role of keratinocyte-derived chemokine (KC) on hyperalgesia caused by peripheral nerve injury in mice.
Topics: Amines; Analgesics; Animals; Antibodies; Chemokines; Cyclohexanecarboxylic Acids; Cyclooxygenase Inh | 2014 |
Can we stop pain before it starts?
Topics: Analgesics; Animals; Chronic Pain; gamma-Aminobutyric Acid; Male; Pain Measurement; Peripheral Nerve | 2014 |
Differential upregulation in DRG neurons of an α2δ-1 splice variant with a lower affinity for gabapentin after peripheral sensory nerve injury.
Topics: Amines; Animals; Calcium Channels; Calcium Channels, L-Type; Cyclohexanecarboxylic Acids; Gabapentin | 2014 |
Peripheral nerve injury and gabapentin, but not their combination, impair attentional behavior via direct effects on noradrenergic signaling in the brain.
Topics: Adrenergic Neurons; Amines; Analgesics; Animals; Attention; Behavior, Animal; Chronic Pain; Cyclohex | 2014 |
Menin regulates spinal glutamate-GABA balance through GAD65 contributing to neuropathic pain.
Topics: Animals; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Male; Mice; Mice, Inbred C | 2014 |
Gabapentin, a double-agent acting on cognition in pain?
Topics: Adrenergic Neurons; Amines; Analgesics; Animals; Attention; Behavior, Animal; Chronic Pain; Cyclohex | 2014 |
Antinociceptive synergism of gabapentin and nortriptyline in mice with partial sciatic nerve ligation.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Drug Synergism; Drug Therapy, Combination; | 2015 |
Gabapentin alleviates affective pain after traumatic nerve injury.
Topics: Affect; Amines; Analgesics; Animals; Conditioning, Psychological; Cyclohexanecarboxylic Acids; Gabap | 2015 |
Astrocytes and Microglia-Mediated Immune Response in Maladaptive Plasticity is Differently Modulated by NGF in the Ventral Horn of the Spinal Cord Following Peripheral Nerve Injury.
Topics: Animals; Antigens, Nuclear; Astrocytes; Biomarkers; Calcium-Binding Proteins; Chromatography, High P | 2016 |
Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition.
Topics: Animals; Disease Models, Animal; Exons; gamma-Aminobutyric Acid; Hyperalgesia; K Cl- Cotransporters; | 2016 |
Modulation of Matrix Metalloproteinases Activity in the Ventral Horn of the Spinal Cord Re-stores Neuroglial Synaptic Homeostasis and Neurotrophic Support following Peripheral Nerve Injury.
Topics: Animals; Anterior Horn Cells; Astrocytes; Dipeptides; gamma-Aminobutyric Acid; Gelatinases; Glutamat | 2016 |
Reductions in tonic GABAergic current in substantia gelatinosa neurons and GABA
Topics: Animals; Constriction; Disease Models, Animal; gamma-Aminobutyric Acid; Lumbar Vertebrae; Mice; Neur | 2016 |
Gabapentin loses efficacy over time after nerve injury in rats: role of glutamate transporter-1 in the locus coeruleus.
Topics: Amines; Analgesics; Animals; Antihypertensive Agents; Atropine; Bronchodilator Agents; Clonidine; CR | 2016 |
Neuroprotective Effect of Genistein in Peripheral Nerve Injury.
Topics: Amines; Animals; Anti-Inflammatory Agents; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyr | 2017 |
High-resolution sonography of posttraumatic neuroma of the superficial radial nerve.
Topics: Analgesics; Bone Plates; Female; gamma-Aminobutyric Acid; Humans; Middle Aged; Neuroma; Neurosurgica | 2011 |
Rewarding electrical brain stimulation in rats after peripheral nerve injury: decreased facilitation by commonly abused prescription opioids.
Topics: Adenosine; Amines; Analgesics; Analgesics, Opioid; Animals; Brain; Clonidine; Cyclohexanecarboxylic | 2011 |
Spontaneous burrowing behaviour in the rat is reduced by peripheral nerve injury or inflammation associated pain.
Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Cyclohexanec | 2012 |
Gabapentin inhibits γ-amino butyric acid release in the locus coeruleus but not in the spinal dorsal horn after peripheral nerve injury in rats.
Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Excitatory Amino Acid Antagonists; Extracellular Space | 2012 |
Ondansetron reverses antihypersensitivity from clonidine in rats after peripheral nerve injury: role of γ-aminobutyric acid in α2-adrenoceptor and 5-HT3 serotonin receptor analgesia.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesia; Animals; Clonidine; Disease Models, Animal; gamma-A | 2012 |
Relief of hypersensitivity after nerve injury from systemic donepezil involves spinal cholinergic and γ-aminobutyric acid mechanisms.
Topics: Animals; Atropine; Bicuculline; Cholinergic Agents; Cholinesterase Inhibitors; Disease Models, Anima | 2013 |
Salt and wounds: a new mechanism for neuropathic pain.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Glycine; Humans; K Cl- Cotransporters; Ner | 2003 |
Release of BDNF and GABA in the dorsal horn of neuropathic rats.
Topics: Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Electric Stimulation; Functional Later | 2003 |
A nitric oxide (NO)-releasing derivative of gabapentin, NCX 8001, alleviates neuropathic pain-like behavior after spinal cord and peripheral nerve injury.
Topics: Acetates; Amines; Animals; Aorta, Thoracic; Behavior, Animal; Cyclic GMP; Cyclohexanecarboxylic Acid | 2004 |
Behavioral and pharmacological characterization of a distal peripheral nerve injury in the rat.
Topics: Amines; Analgesics; Animals; Cold Temperature; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminob | 2005 |
The effect of antinociceptive drugs tested at different times after nerve injury in rats.
Topics: Amines; Analgesics; Animals; Antidepressive Agents, Tricyclic; Cyclohexanecarboxylic Acids; Dose-Res | 2005 |
Spinal nerve ligation does not alter the expression or function of GABA(B) receptors in spinal cord and dorsal root ganglia of the rat.
Topics: Animals; Baclofen; Denervation; Disease Models, Animal; GABA Agonists; gamma-Aminobutyric Acid; Gang | 2006 |
Receptor autoradiographic correlates of deafferentation-induced reorganization in adult primate somatosensory cortex.
Topics: Afferent Pathways; Animals; Autoradiography; Binding, Competitive; Denervation; gamma-Aminobutyric A | 2006 |
The importance of genetic background on pain behaviours and pharmacological sensitivity in the rat spared serve injury model of peripheral neuropathic pain.
Topics: Amines; Analgesics; Analgesics, Opioid; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal | 2007 |
Discovery of 4-aminobutyric acid derivatives possessing anticonvulsant and antinociceptive activities: a hybrid pharmacophore approach.
Topics: Analgesics; Animals; Anticonvulsants; Disease Models, Animal; gamma-Aminobutyric Acid; Hyperalgesia; | 2007 |
Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil.
Topics: Administration, Oral; Amines; Analgesics; Animals; Cholinesterase Inhibitors; Cyclohexanecarboxylic | 2007 |
Loss of GABA-immunoreactivity in the spinal dorsal horn of rats with peripheral nerve injury and promotion of recovery by adrenal medullary grafts.
Topics: Adrenal Medulla; Animals; Behavior, Animal; Cell Transplantation; Chromaffin Cells; gamma-Aminobutyr | 1997 |
Gabapentin suppresses ectopic nerve discharges and reverses allodynia in neuropathic rats.
Topics: Acetates; Afferent Pathways; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Disease | 1999 |
Injury-induced reorganization of somatosensory cortex is accompanied by reductions in GABA staining.
Topics: Afferent Pathways; Animals; Brain Mapping; Dominance, Cerebral; Electron Transport Complex IV; gamma | 1991 |
Changes in neurotransmitter uptake in the spinal cord following peripheral nerve injury.
Topics: Aminooxyacetic Acid; Animals; Choline; Female; Functional Laterality; gamma-Aminobutyric Acid; Gluta | 1988 |