Page last updated: 2024-10-16

gamma-aminobutyric acid and Pelvic Pain

gamma-aminobutyric acid has been researched along with Pelvic Pain in 20 studies

gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.

Pelvic Pain: Pain in the pelvic region of genital and non-genital origin.

Research Excerpts

ExcerptRelevanceReference
" Gabapentin (a GABA analogue) is efficacious and often well tolerated in other chronic pain conditions."9.27GaPP2, a multicentre randomised controlled trial of the efficacy of gabapentin for the management of chronic pelvic pain in women: study protocol. ( Baranowski, A; Bhattacharya, S; Birch, J; Cheong, Y; Cregg, R; Daniels, J; Hewitt, CA; Horne, AW; Macfarlane, GJ; Middleton, L; Szubert, W; Tracey, I; Vincent, K; Williams, ACC, 2018)
" Based on the efficacy of gabapentin in the treatment of chronic pain, we conducted this study to evaluate the efficacy and safety of gabapentin in reducing pain in women with CPP."9.22Is gabapentin effective and safe in the treatment of chronic pelvic pain in women: a systematic review and meta-analysis. ( He, Y; Ma, W; Zhuang, X, 2022)
"The aim of this study was to compare the efficacy and side effects of gabapentin, amitriptyline, and their combination in women with chronic pelvic pain."9.11Chronic pelvic pain treated with gabapentin and amitriptyline: a randomized controlled pilot study. ( Ellend, A; Frickey, N; Gleiss, A; Kozek-Langenecker, SA; Kress, HG; Sator-Katzenschlager, SM; Scharbert, G, 2005)
"Gabapentin alone or in combination with amitriptyline is better than amitriptyline alone in the treatment of female chronic pelvic pain."9.11Chronic pelvic pain treated with gabapentin and amitriptyline: a randomized controlled pilot study. ( Ellend, A; Frickey, N; Gleiss, A; Kozek-Langenecker, SA; Kress, HG; Sator-Katzenschlager, SM; Scharbert, G, 2005)
"gov, Google Scholar, and reference lists of articles and abstracts from conference proceedings, without language restriction for pregabalin treatment of Class III prostatitis and CP/CPPS."8.88Pregabalin for chronic prostatitis. ( Aboumarzouk, OM; Nelson, RL, 2012)
" Pregabalin dosage was increased from 150 to 600 mg/d during the first 4 weeks."6.75Pregabalin for the treatment of men with chronic prostatitis/chronic pelvic pain syndrome: a randomized controlled trial. ( Alexander, RB; Anderson, RU; Cen, L; Chuai, S; Krieger, JN; Kusek, JW; Landis, JR; Litwin, MS; McNaughton-Collins, M; Nickel, JC; Nyberg, LM; O'Leary, M; Pontari, MA; Propert, KJ; Schaeffer, AJ; Shoskes, DA; White, PC; Zeitlin, S, 2010)
" Gabapentin (a GABA analogue) is efficacious and often well tolerated in other chronic pain conditions."5.27GaPP2, a multicentre randomised controlled trial of the efficacy of gabapentin for the management of chronic pelvic pain in women: study protocol. ( Baranowski, A; Bhattacharya, S; Birch, J; Cheong, Y; Cregg, R; Daniels, J; Hewitt, CA; Horne, AW; Macfarlane, GJ; Middleton, L; Szubert, W; Tracey, I; Vincent, K; Williams, ACC, 2018)
" Based on the efficacy of gabapentin in the treatment of chronic pain, we conducted this study to evaluate the efficacy and safety of gabapentin in reducing pain in women with CPP."5.22Is gabapentin effective and safe in the treatment of chronic pelvic pain in women: a systematic review and meta-analysis. ( He, Y; Ma, W; Zhuang, X, 2022)
"The aim of this study was to compare the efficacy and side effects of gabapentin, amitriptyline, and their combination in women with chronic pelvic pain."5.11Chronic pelvic pain treated with gabapentin and amitriptyline: a randomized controlled pilot study. ( Ellend, A; Frickey, N; Gleiss, A; Kozek-Langenecker, SA; Kress, HG; Sator-Katzenschlager, SM; Scharbert, G, 2005)
"Gabapentin alone or in combination with amitriptyline is better than amitriptyline alone in the treatment of female chronic pelvic pain."5.11Chronic pelvic pain treated with gabapentin and amitriptyline: a randomized controlled pilot study. ( Ellend, A; Frickey, N; Gleiss, A; Kozek-Langenecker, SA; Kress, HG; Sator-Katzenschlager, SM; Scharbert, G, 2005)
"gov, Google Scholar, and reference lists of articles and abstracts from conference proceedings, without language restriction for pregabalin treatment of Class III prostatitis and CP/CPPS."4.88Pregabalin for chronic prostatitis. ( Aboumarzouk, OM; Nelson, RL, 2012)
"15 women with pelvic pain and laparoscopically confirmed endometriosis and 10 healthy, symptom-free, control women, aged 18-40 years, underwent the diazepam challenge test during the follicular phase of the menstrual cycle."4.31Altered GABA ( Bäckström, T; Bixo, M; Möller, A; Sandström, A; Turkmen, S, 2023)
" Pregabalin dosage was increased from 150 to 600 mg/d during the first 4 weeks."2.75Pregabalin for the treatment of men with chronic prostatitis/chronic pelvic pain syndrome: a randomized controlled trial. ( Alexander, RB; Anderson, RU; Cen, L; Chuai, S; Krieger, JN; Kusek, JW; Landis, JR; Litwin, MS; McNaughton-Collins, M; Nickel, JC; Nyberg, LM; O'Leary, M; Pontari, MA; Propert, KJ; Schaeffer, AJ; Shoskes, DA; White, PC; Zeitlin, S, 2010)
"Chronic pelvic pain is a common and debilitating condition; its aetiology is multifactorial, involving social, psychological and biological factors."2.50Non-surgical interventions for the management of chronic pelvic pain. ( Cheong, YC; Smotra, G; Williams, AC, 2014)
"Recent awareness that chronic pain may occur after childbirth has prompted clinicians and researchers to investigate this topic."2.49Chronic pain after childbirth. ( Bollag, L; Landau, R; Ortner, C, 2013)
"The analysis of the case of vulvodynia coexisting with depression."1.46Vulvodynia and depression - a case study. ( Derewianka-Polak, M; Dziwota, EA; Gerhant, A; Olajossy, M; Perzyńska-Starkiewicz, A, 2017)
"Pelvic pain was detected 5 days after antigen instillation and was sustained beyond 30 days, indicating the development of chronic pain."1.35Experimental autoimmune prostatitis induces chronic pelvic pain. ( Rudick, CN; Schaeffer, AJ; Thumbikat, P, 2008)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (10.00)18.2507
2000's5 (25.00)29.6817
2010's11 (55.00)24.3611
2020's2 (10.00)2.80

Authors

AuthorsStudies
He, Y1
Zhuang, X1
Ma, W1
Sandström, A1
Bixo, M1
Bäckström, T1
Möller, A1
Turkmen, S1
Horne, AW3
Vincent, K3
Cregg, R2
Daniels, J2
Harper, DE1
Ichesco, E1
Schrepf, A1
Halvorson, M1
Puiu, T1
Clauw, DJ1
Harris, RE1
Harte, SE1
Gerhant, A1
Dziwota, EA1
Perzyńska-Starkiewicz, A1
Derewianka-Polak, M1
Olajossy, M1
Baranowski, A1
Bhattacharya, S2
Birch, J1
Cheong, Y1
Hewitt, CA1
Macfarlane, GJ1
Middleton, L1
Szubert, W1
Tracey, I1
Williams, ACC1
Landau, R1
Bollag, L1
Ortner, C1
Cheong, YC1
Smotra, G1
Williams, AC1
Lewis, SC1
Wu, O1
Jack, SA1
Critchley, HO1
Porter, MA1
Cranley, D1
Wilson, JA1
Levy, BS1
Apgar, BS1
Strauss, AC1
Dimitrakov, JD1
Pontari, MA1
Krieger, JN1
Litwin, MS1
White, PC1
Anderson, RU1
McNaughton-Collins, M1
Nickel, JC1
Shoskes, DA1
Alexander, RB1
O'Leary, M1
Zeitlin, S1
Chuai, S1
Landis, JR1
Cen, L1
Propert, KJ1
Kusek, JW1
Nyberg, LM1
Schaeffer, AJ2
Berger, RE1
Aboumarzouk, OM1
Nelson, RL1
Sator-Katzenschlager, SM1
Scharbert, G1
Kress, HG1
Frickey, N1
Ellend, A1
Gleiss, A1
Kozek-Langenecker, SA1
Rudick, CN1
Thumbikat, P1
Solaro, C1
Uccelli, MM1
Mancardi, GL1
Ben-David, B1
Friedman, M1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Diagnostic Challenges in IC (and Male CPPS)[NCT00672087]1,000 participants (Anticipated)Observational2003-09-30Completed
A Randomized, Placebo-controlled Multi-center Clinical Trial to Evaluate the Efficacy and Safety of Pregabalin for the Treatment of Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS)[NCT00371033]Phase 3318 participants (Anticipated)Interventional2006-03-31Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

6 reviews available for gamma-aminobutyric acid and Pelvic Pain

ArticleYear
Is gabapentin effective and safe in the treatment of chronic pelvic pain in women: a systematic review and meta-analysis.
    International urogynecology journal, 2022, Volume: 33, Issue:5

    Topics: Amines; Analgesics; Chronic Pain; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyri

2022
Chronic pain after childbirth.
    International journal of obstetric anesthesia, 2013, Volume: 22, Issue:2

    Topics: Acute Pain; Adrenergic alpha-Agonists; Adult; Amines; Analgesics; Anesthetics, Dissociative; Cesarea

2013
Non-surgical interventions for the management of chronic pelvic pain.
    The Cochrane database of systematic reviews, 2014, Mar-05, Issue:3

    Topics: Amines; Amitriptyline; Analgesics; Chronic Pain; Clonidine; Contraceptive Agents, Female; Cyclohexan

2014
The complex nature of chronic pelvic pain.
    The Journal of family practice, 2007, Volume: 56, Issue:3 Suppl Di

    Topics: Adult; Amines; Anti-Anxiety Agents; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents,

2007
New treatments for chronic prostatitis/chronic pelvic pain syndrome.
    Nature reviews. Urology, 2010, Volume: 7, Issue:3

    Topics: Amines; Chronic Disease; Cognitive Behavioral Therapy; Cyclohexanecarboxylic Acids; Gabapentin; gamm

2010
Pregabalin for chronic prostatitis.
    The Cochrane database of systematic reviews, 2012, Aug-15, Issue:8

    Topics: Analgesics; Chronic Disease; gamma-Aminobutyric Acid; Humans; Male; Pelvic Pain; Pregabalin; Prostat

2012

Trials

4 trials available for gamma-aminobutyric acid and Pelvic Pain

ArticleYear
GaPP2, a multicentre randomised controlled trial of the efficacy of gabapentin for the management of chronic pelvic pain in women: study protocol.
    BMJ open, 2018, 01-31, Volume: 8, Issue:1

    Topics: Adolescent; Adult; Amines; Analgesics; Chronic Disease; Chronic Pain; Cyclohexanecarboxylic Acids; D

2018
Gabapentin for the Management of Chronic Pelvic Pain in Women (GaPP1): A Pilot Randomised Controlled Trial.
    PloS one, 2016, Volume: 11, Issue:4

    Topics: Adolescent; Adult; Amines; Analgesics; Chronic Pain; Cost-Benefit Analysis; Cyclohexanecarboxylic Ac

2016
Pregabalin for the treatment of men with chronic prostatitis/chronic pelvic pain syndrome: a randomized controlled trial.
    Archives of internal medicine, 2010, Sep-27, Volume: 170, Issue:17

    Topics: Adult; Aged; Analgesics; Canada; Chronic Disease; Double-Blind Method; gamma-Aminobutyric Acid; Hosp

2010
Chronic pelvic pain treated with gabapentin and amitriptyline: a randomized controlled pilot study.
    Wiener klinische Wochenschrift, 2005, Volume: 117, Issue:21-22

    Topics: Adult; Amines; Amitriptyline; Austria; Chronic Disease; Cyclohexanecarboxylic Acids; Drug Combinatio

2005

Other Studies

10 other studies available for gamma-aminobutyric acid and Pelvic Pain

ArticleYear
Altered GABA
    Acta obstetricia et gynecologica Scandinavica, 2023, Volume: 102, Issue:10

    Topics: Diazepam; Endometriosis; Female; gamma-Aminobutyric Acid; Gonadal Steroid Hormones; Humans; Pelvic P

2023
Is gabapentin effective for women with unexplained chronic pelvic pain?
    BMJ (Clinical research ed.), 2017, 09-21, Volume: 358

    Topics: Amines; Analgesics; Chronic Pain; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyri

2017
Relationships between brain metabolite levels, functional connectivity, and negative mood in urologic chronic pelvic pain syndrome patients compared to controls: A MAPP research network study.
    NeuroImage. Clinical, 2018, Volume: 17

    Topics: Adult; Brain; Choline; Chronic Pain; Cross-Sectional Studies; Emotions; Female; gamma-Aminobutyric A

2018
Vulvodynia and depression - a case study.
    Psychiatria polska, 2017, Oct-29, Volume: 51, Issue:5

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Depression; Female; Gabapentin; gamma-Aminobutyric

2017
Challenges of fragmented care in long-term management of pelvic pain.
    The Journal of family practice, 2007, Volume: 56, Issue:3 Suppl Di

    Topics: Acetaminophen; Adult; Amines; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Anxiety Agents; Chr

2007
Neuropathic pevic pain--a personal experience.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2008, Volume: 98, Issue:12

    Topics: Analgesics; gamma-Aminobutyric Acid; Humans; Male; Pain, Postoperative; Pelvic Pain; Peripheral Nerv

2008
Re: Pregabalin for the treatment of men with chronic prostatitis/chronic pelvic pain syndrome: a randomized controlled trial.
    The Journal of urology, 2011, Volume: 185, Issue:4

    Topics: Analgesics; gamma-Aminobutyric Acid; Humans; Male; Pelvic Pain; Prostatitis

2011
Experimental autoimmune prostatitis induces chronic pelvic pain.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2008, Volume: 294, Issue:4

    Topics: Amines; Analgesics; Anesthetics, Local; Animals; Autoimmune Diseases; Chronic Disease; Cyclohexaneca

2008
A patient with multiple sclerosis and Down's syndrome with a rare paroxysmal symptom at onset.
    European journal of neurology, 1999, Volume: 6, Issue:4

    Topics: Acetates; Amines; Brain; Cyclohexanecarboxylic Acids; Down Syndrome; Excitatory Amino Acid Antagonis

1999
Gabapentin therapy for vulvodynia.
    Anesthesia and analgesia, 1999, Volume: 89, Issue:6

    Topics: Acetates; Adult; Aged; Aged, 80 and over; Amines; Analgesics; Chronic Disease; Cyclohexanecarboxylic

1999