gamma-aminobutyric acid has been researched along with Parkinsonian Disorders in 72 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
Parkinsonian Disorders: A group of disorders which feature impaired motor control characterized by bradykinesia, MUSCLE RIGIDITY; TREMOR; and postural instability. Parkinsonian diseases are generally divided into primary parkinsonism (see PARKINSON DISEASE), secondary parkinsonism (see PARKINSON DISEASE, SECONDARY) and inherited forms. These conditions are associated with dysfunction of dopaminergic or closely related motor integration neuronal pathways in the BASAL GANGLIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We review occupational Mn-induced parkinsonism and the dynamic modes of Mn transport in biological systems, as well as the detection and pharmacokinetic modeling of Mn trafficking." | 2.52 | Manganese-Induced Parkinsonism and Parkinson's Disease: Shared and Distinguishable Features. ( Aschner, M; Bowman, AB; Kwakye, GF; Mukhopadhyay, S; Paoliello, MM, 2015) |
| "It is hard to define what ratio of insomnia and daytime hypersomnia is caused by the antiparkinsonian treatment, by the somatic and mental-emotional symptoms of the neurodegenerative disease and by the neurodegenerative brain process itself." | 2.44 | [Sleep disorders in Parkinson syndromes]. ( Kovács, GG; Lalit, N; Péter, H; Szucs, A, 2007) |
| "Among 5,653,547 reports, 4925 parkinsonism reports were found with pregabalin and 4881 with gabapentin." | 1.56 | Parkinsonism associated with gabapentinoid drugs: A pharmacoepidemiologic study. ( Chebane, L; Lapeyre-Mestre, M; Montastruc, F; Montastruc, JL; Pacheco-Paez, T; Renoux, C; Rousseau, V, 2020) |
| "In a mouse model of early parkinsonism, GATs are downregulated, tonic GABAergic inhibition of DA release augmented, and nigrostriatal GABA co-release attenuated." | 1.56 | GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model. ( Bengoa-Vergniory, N; Brimblecombe, KR; Connor-Robson, N; Cragg, SJ; Doig, NM; Lopes, EF; Magill, PJ; Pasternack, N; Roberts, BM; Siddorn, RE; Threlfell, S; Wade-Martins, R, 2020) |
| "Recent data showed that rats induced to Parkinsonism by 6-hydroxydopamine (6-OHDA) administration in the substantia nigra pars compacta (SNpc) showed lower mean arterial pressure (MAP) and heart rate (HR), as reduction in sympathetic modulation." | 1.51 | Glutamate and GABA neurotransmission are increased in paraventricular nucleus of hypothalamus in rats induced to 6-OHDA parkinsonism: Involvement of nNOS. ( Ariza, D; Crestani, CC; Cruz Lucchetti, BF; de Jager, L; Martins, AB; Martins-Pinge, MC; Pinge-Filho, P; Rodrigues, AT; Turossi Amorim, ED; Uchoa, ET, 2019) |
| "The onset of motor deficits in parkinsonism is thought to result from dopamine (DA) loss-induced corticostriatal disruption and the development of excessive cortico-basal ganglia synchronization." | 1.46 | Frequency-Dependent Corticostriatal Disinhibition Resulting from Chronic Dopamine Depletion: Role of Local Striatal cGMP and GABA-AR Signaling. ( Flores-Barrera, E; Jayasinghe, VR; Tseng, KY; West, AR, 2017) |
| "Manganese treatment produced increased aspartate (P < 0." | 1.31 | Low cumulative manganese exposure affects striatal GABA but not dopamine. ( Gwiazda, RH; Lee, D; Sheridan, J; Smith, DR, 2002) |
| " A sub-chronic dosing regimen of low cumulative manganese exposure (4." | 1.31 | Low cumulative manganese exposure affects striatal GABA but not dopamine. ( Gwiazda, RH; Lee, D; Sheridan, J; Smith, DR, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 37 (51.39) | 29.6817 |
| 2010's | 28 (38.89) | 24.3611 |
| 2020's | 7 (9.72) | 2.80 |
| Authors | Studies |
|---|---|
| Guo, Y | 2 |
| Zhu, H | 1 |
| Wang, Y | 3 |
| Sun, T | 1 |
| Xu, J | 1 |
| Wang, T | 2 |
| Guan, W | 1 |
| Wang, C | 1 |
| Liu, C | 1 |
| Ma, C | 1 |
| Abe, Y | 1 |
| Yagishita, S | 1 |
| Sano, H | 1 |
| Sugiura, Y | 1 |
| Dantsuji, M | 1 |
| Suzuki, T | 1 |
| Mochizuki, A | 1 |
| Yoshimaru, D | 1 |
| Hata, J | 1 |
| Matsumoto, M | 1 |
| Taira, S | 1 |
| Takeuchi, H | 1 |
| Okano, H | 1 |
| Ohno, N | 1 |
| Suematsu, M | 1 |
| Inoue, T | 1 |
| Nambu, A | 1 |
| Watanabe, M | 1 |
| Tanaka, KF | 1 |
| Pacheco-Paez, T | 1 |
| Montastruc, F | 1 |
| Rousseau, V | 1 |
| Chebane, L | 1 |
| Lapeyre-Mestre, M | 1 |
| Renoux, C | 1 |
| Montastruc, JL | 1 |
| Kiessling, CY | 1 |
| Lanza, K | 1 |
| Feinberg, E | 1 |
| Bishop, C | 2 |
| Nishijima, H | 1 |
| Mori, F | 1 |
| Arai, A | 1 |
| Zhu, G | 1 |
| Wakabayashi, K | 1 |
| Okada, M | 1 |
| Ueno, S | 1 |
| Ichinohe, N | 1 |
| Suzuki, C | 1 |
| Kon, T | 1 |
| Tomiyama, M | 1 |
| Brugnoli, A | 1 |
| Pisanò, CA | 1 |
| Morari, M | 6 |
| Roberts, BM | 1 |
| Doig, NM | 1 |
| Brimblecombe, KR | 1 |
| Lopes, EF | 1 |
| Siddorn, RE | 1 |
| Threlfell, S | 1 |
| Connor-Robson, N | 1 |
| Bengoa-Vergniory, N | 1 |
| Pasternack, N | 1 |
| Wade-Martins, R | 1 |
| Magill, PJ | 1 |
| Cragg, SJ | 1 |
| Sun, YN | 1 |
| Yao, L | 2 |
| Li, LB | 1 |
| Du, CX | 1 |
| Liu, J | 2 |
| Turossi Amorim, ED | 1 |
| de Jager, L | 1 |
| Martins, AB | 1 |
| Rodrigues, AT | 1 |
| Cruz Lucchetti, BF | 1 |
| Ariza, D | 1 |
| Pinge-Filho, P | 1 |
| Crestani, CC | 1 |
| Uchoa, ET | 1 |
| Martins-Pinge, MC | 1 |
| Liu, Y | 2 |
| Zong, X | 1 |
| Huang, J | 1 |
| Guan, Y | 1 |
| Li, Y | 1 |
| Du, T | 1 |
| Liu, K | 1 |
| Kang, X | 1 |
| Dou, C | 1 |
| Sun, X | 1 |
| Wu, R | 1 |
| Wen, L | 1 |
| Zhang, Y | 1 |
| López-Huerta, VG | 1 |
| Carrillo-Reid, L | 1 |
| Galarraga, E | 1 |
| Tapia, D | 1 |
| Fiordelisio, T | 1 |
| Drucker-Colin, R | 1 |
| Bargas, J | 1 |
| Fu, A | 1 |
| Zhao, Z | 1 |
| Gao, F | 1 |
| Zhang, M | 1 |
| Smith, KM | 1 |
| Browne, SE | 1 |
| Jayaraman, S | 1 |
| Bleickardt, CJ | 1 |
| Hodge, LM | 1 |
| Lis, E | 1 |
| Rittle, SL | 1 |
| Innocent, N | 1 |
| Mullins, DE | 1 |
| Boykow, G | 1 |
| Reynolds, IJ | 1 |
| Hill, D | 1 |
| Parker, EM | 1 |
| Hodgson, RA | 1 |
| Cremer, JN | 1 |
| Amunts, K | 1 |
| Graw, J | 1 |
| Piel, M | 1 |
| Rösch, F | 1 |
| Zilles, K | 1 |
| Chu, HY | 1 |
| Atherton, JF | 1 |
| Wokosin, D | 1 |
| Surmeier, DJ | 1 |
| Bevan, MD | 1 |
| Mastro, KJ | 1 |
| Gittis, AH | 1 |
| Papa, SM | 1 |
| Wichmann, T | 1 |
| Kwakye, GF | 1 |
| Paoliello, MM | 1 |
| Mukhopadhyay, S | 1 |
| Bowman, AB | 1 |
| Aschner, M | 1 |
| Borgkvist, A | 1 |
| Avegno, EM | 1 |
| Wong, MY | 1 |
| Kheirbek, MA | 1 |
| Sonders, MS | 1 |
| Hen, R | 1 |
| Sulzer, D | 1 |
| Jayasinghe, VR | 1 |
| Flores-Barrera, E | 1 |
| West, AR | 1 |
| Tseng, KY | 1 |
| McCreary, AC | 1 |
| Varney, MA | 1 |
| Newman-Tancredi, A | 1 |
| Lindenbach, D | 1 |
| Conti, MM | 1 |
| Ostock, CY | 1 |
| George, JA | 1 |
| Goldenberg, AA | 1 |
| Melikhov-Sosin, M | 1 |
| Nuss, EE | 1 |
| Wei, W | 1 |
| Ding, S | 1 |
| Zhou, FM | 1 |
| Rangel-Barajas, C | 2 |
| Silva, I | 2 |
| García-Ramírez, M | 1 |
| Sánchez-Lemus, E | 1 |
| Floran, L | 1 |
| Aceves, J | 3 |
| Erlij, D | 3 |
| Florán, B | 3 |
| Barroso-Chinea, P | 1 |
| Rico, AJ | 1 |
| Pérez-Manso, M | 1 |
| Roda, E | 1 |
| López, IP | 1 |
| Luis-Ravelo, D | 1 |
| Lanciego, JL | 1 |
| Thompson, LH | 1 |
| Kirik, D | 2 |
| Björklund, A | 2 |
| Mukhida, K | 1 |
| Hong, M | 1 |
| Miles, GB | 1 |
| Phillips, T | 1 |
| Baghbaderani, BA | 1 |
| McLeod, M | 1 |
| Kobayashi, N | 1 |
| Sen, A | 1 |
| Behie, LA | 1 |
| Brownstone, RM | 1 |
| Mendez, I | 1 |
| Boulet, S | 1 |
| Mounayar, S | 1 |
| Poupard, A | 2 |
| Bertrand, A | 2 |
| Jan, C | 1 |
| Pessiglione, M | 1 |
| Hirsch, EC | 1 |
| Feuerstein, C | 2 |
| François, C | 1 |
| Féger, J | 1 |
| Savasta, M | 2 |
| Tremblay, L | 1 |
| Marti, M | 5 |
| Trapella, C | 2 |
| Mabrouk, OS | 3 |
| Volta, M | 1 |
| Freund, HJ | 1 |
| Kuhn, J | 1 |
| Lenartz, D | 1 |
| Mai, JK | 1 |
| Schnell, T | 1 |
| Klosterkoetter, J | 1 |
| Sturm, V | 1 |
| Nandhu, MS | 1 |
| Fabia, ET | 1 |
| Paulose, CS | 1 |
| Salvadori, S | 1 |
| Korkmaz, OT | 1 |
| Tunçel, N | 1 |
| Tunçel, M | 1 |
| Oncü, EM | 1 |
| Sahintürk, V | 1 |
| Celik, M | 1 |
| Zhang, QJ | 1 |
| Ali, U | 1 |
| Gui, ZH | 1 |
| Hui, YP | 1 |
| Chen, L | 1 |
| Lopéz-Santiago, LM | 1 |
| Venero, JL | 1 |
| Mauriño, R | 1 |
| Machado, A | 1 |
| Santiago, M | 1 |
| Hutter-Saunders, JA | 1 |
| Kosloski, LM | 1 |
| McMillan, JM | 1 |
| Yotam, N | 1 |
| Rinat, T | 1 |
| Mosley, RL | 1 |
| Gendelman, HE | 1 |
| McCarthy, MM | 1 |
| Moore-Kochlacs, C | 1 |
| Gu, X | 1 |
| Boyden, ES | 1 |
| Han, X | 1 |
| Kopell, N | 1 |
| Ferraro, L | 1 |
| O'Connor, WT | 1 |
| Beggiato, S | 1 |
| Tomasini, MC | 1 |
| Fuxe, K | 1 |
| Tanganelli, S | 1 |
| Antonelli, T | 1 |
| Samoudi, G | 1 |
| Nissbrandt, H | 1 |
| Dutia, MB | 1 |
| Bergquist, F | 1 |
| Coune, PG | 1 |
| Craveiro, M | 1 |
| Gaugler, MN | 1 |
| Mlynárik, V | 1 |
| Schneider, BL | 1 |
| Aebischer, P | 1 |
| Gruetter, R | 1 |
| Dehorter, N | 1 |
| Lozovaya, N | 1 |
| Mdzomba, BJ | 1 |
| Michel, FJ | 1 |
| Lopez, C | 1 |
| Tsintsadze, V | 1 |
| Tsintsadze, T | 1 |
| Klinkenberg, M | 1 |
| Gispert, S | 1 |
| Auburger, G | 1 |
| Hammond, C | 1 |
| McCormack, AL | 1 |
| Thiruchelvam, M | 1 |
| Manning-Bog, AB | 1 |
| Thiffault, C | 1 |
| Langston, JW | 1 |
| Cory-Slechta, DA | 1 |
| Di Monte, DA | 1 |
| Schroeder, JA | 1 |
| Schneider, JS | 1 |
| Gwiazda, RH | 1 |
| Lee, D | 1 |
| Sheridan, J | 1 |
| Smith, DR | 1 |
| Luo, J | 1 |
| Kaplitt, MG | 1 |
| Fitzsimons, HL | 1 |
| Zuzga, DS | 1 |
| Oshinsky, ML | 1 |
| During, MJ | 1 |
| Nandi, D | 1 |
| Aziz, TZ | 1 |
| Giladi, N | 1 |
| Winter, J | 1 |
| Stein, JF | 1 |
| Fox, SH | 1 |
| Henry, B | 1 |
| Hill, M | 1 |
| Crossman, A | 1 |
| Brotchie, J | 1 |
| Gerstein, LM | 1 |
| Dovedova, EL | 1 |
| Popova, NS | 1 |
| Alfinito, PD | 1 |
| Wang, SP | 1 |
| Manzino, L | 1 |
| Rijhsinghani, S | 1 |
| Zeevalk, GD | 1 |
| Sonsalla, PK | 1 |
| Kase, H | 4 |
| Aoyama, S | 1 |
| Ichimura, M | 1 |
| Ikeda, K | 1 |
| Ishii, A | 1 |
| Kanda, T | 1 |
| Koga, K | 1 |
| Koike, N | 1 |
| Kurokawa, M | 1 |
| Kuwana, Y | 1 |
| Mori, A | 1 |
| Nakamura, J | 1 |
| Nonaka, H | 1 |
| Ochi, M | 3 |
| Saki, M | 1 |
| Shimada, J | 1 |
| Shindou, T | 1 |
| Shiozaki, S | 3 |
| Suzuki, F | 1 |
| Takeda, M | 1 |
| Yanagawa, K | 1 |
| Richardson, PJ | 1 |
| Jenner, P | 1 |
| Bedard, P | 1 |
| Borrelli, E | 1 |
| Hauser, RA | 1 |
| Chase, TN | 1 |
| Bruet, N | 1 |
| Windels, F | 1 |
| Carcenac, C | 1 |
| Stephenson, DT | 1 |
| Li, Q | 1 |
| Simmons, C | 1 |
| Connell, MA | 1 |
| Meglasson, MD | 1 |
| Merchant, K | 1 |
| Emborg, ME | 1 |
| Mazloom, M | 1 |
| Smith, Y | 1 |
| Mallet, N | 1 |
| Ballion, B | 1 |
| Le Moine, C | 1 |
| Gonon, F | 1 |
| Suon, S | 1 |
| Yang, M | 1 |
| Iacovitti, L | 1 |
| Yamamoto, N | 1 |
| Pierce, RC | 1 |
| Soghomonian, JJ | 2 |
| Wang, H | 1 |
| Katz, J | 1 |
| Dagostino, P | 1 |
| Viaro, R | 1 |
| Yi, PL | 1 |
| Tsai, CH | 1 |
| Lu, MK | 1 |
| Liu, HJ | 1 |
| Chen, YC | 1 |
| Chang, FC | 1 |
| Szucs, A | 1 |
| Kovács, GG | 1 |
| Lalit, N | 1 |
| Péter, H | 1 |
| Struve, MF | 1 |
| McManus, BE | 1 |
| Wong, BA | 1 |
| Dorman, DC | 1 |
| Chassain, C | 1 |
| Bielicki, G | 1 |
| Durand, E | 1 |
| Lolignier, S | 1 |
| Essafi, F | 1 |
| Traoré, A | 1 |
| Durif, F | 1 |
| Carta, AR | 1 |
| Frau, L | 1 |
| Lucia, F | 1 |
| Pinna, A | 1 |
| Annalisa, P | 1 |
| Pontis, S | 1 |
| Silvia, P | 1 |
| Simola, N | 1 |
| Nicola, S | 1 |
| Schintu, N | 1 |
| Nicoletta, S | 1 |
| Morelli, M | 1 |
| Micaela, M | 1 |
| Winkler, C | 1 |
| Dunnett, SB | 1 |
| Galvan, A | 1 |
| Ni, Z | 1 |
| Gao, D | 1 |
| Bouali-Benazzouz, R | 1 |
| Benabid, AL | 1 |
| Benazzouz, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Multi-targets, Single-lead GPi+NBM DBS in Parkinson's Disease With Mild Cognitive Impairment[NCT04571112] | 6 participants (Actual) | Interventional | 2017-12-04 | Completed | |||
| Simultaneous Deep Brain Stimulation of the Globus Pallidus Internus and the Nucleus Basalis of Meynert in Patients With Parkinson's Disease and Mild Cognitive Impairment[NCT05320523] | 10 participants (Anticipated) | Interventional | 2021-07-20 | Recruiting | |||
| Phase I Study of Subthalamic GAD Gene Transfer in Medically Refractory Parkinson's Disease Patients[NCT00195143] | Phase 1 | 12 participants | Interventional | 2003-08-31 | Completed | ||
| A Phase II, Randomized, Open-label, Double-blind, Two-center Study to Evaluate the Tolerability, Safety and Dose-finding of Oil Cannabis Preparation for Pain in Parkinson's Disease[NCT03639064] | Phase 2 | 15 participants (Anticipated) | Interventional | 2020-12-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for gamma-aminobutyric acid and Parkinsonian Disorders
| Article | Year |
|---|---|
Manganese-Induced Parkinsonism and Parkinson's Disease: Shared and Distinguishable Features.
Topics: Brain; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Magnesium; Manganese Poisoning; Par | 2015 |
Progress in pursuit of therapeutic A2A antagonists: the adenosine A2A receptor selective antagonist KW6002: research and development toward a novel nondopaminergic therapy for Parkinson's disease.
Topics: Adenosine A2 Receptor Antagonists; Animals; Antiparkinson Agents; Clinical Trials as Topic; Corpus S | 2003 |
[Sleep disorders in Parkinson syndromes].
Topics: Acetylcholine; Antidepressive Agents; Antiparkinson Agents; Diagnosis, Differential; Disorders of Ex | 2007 |
Transplantation in the rat model of Parkinson's disease: ectopic versus homotopic graft placement.
Topics: Animals; Brain Tissue Transplantation; Disability Evaluation; Disease Models, Animal; Dopamine; gamm | 2000 |
New aspects of physiological and pathophysiological functions of adenosine A2A receptor in basal ganglia.
Topics: Adenosine; Animals; Basal Ganglia; gamma-Aminobutyric Acid; Humans; Models, Neurological; Neurotrans | 2001 |
1 trial available for gamma-aminobutyric acid and Parkinsonian Disorders
| Article | Year |
|---|---|
Cognitive functions in a patient with Parkinson-dementia syndrome undergoing deep brain stimulation.
Topics: Acetylcholine; Aged; Arousal; Attention; Basal Nucleus of Meynert; Cholinergic Fibers; Cognition; Co | 2009 |
Cognitive functions in a patient with Parkinson-dementia syndrome undergoing deep brain stimulation.
Topics: Acetylcholine; Aged; Arousal; Attention; Basal Nucleus of Meynert; Cholinergic Fibers; Cognition; Co | 2009 |
Cognitive functions in a patient with Parkinson-dementia syndrome undergoing deep brain stimulation.
Topics: Acetylcholine; Aged; Arousal; Attention; Basal Nucleus of Meynert; Cholinergic Fibers; Cognition; Co | 2009 |
Cognitive functions in a patient with Parkinson-dementia syndrome undergoing deep brain stimulation.
Topics: Acetylcholine; Aged; Arousal; Attention; Basal Nucleus of Meynert; Cholinergic Fibers; Cognition; Co | 2009 |
66 other studies available for gamma-aminobutyric acid and Parkinsonian Disorders
| Article | Year |
|---|---|
Miniature-swine iPSC-derived GABA progenitor cells function in a rat Parkinson's disease model.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Dopaminergic Neurons; GABAergic Neurons; gamma-Ami | 2023 |
Shared GABA transmission pathology in dopamine agonist- and antagonist-induced dyskinesia.
Topics: Animals; Antiparkinson Agents; Dopamine; Dopamine Agonists; Dyskinesia, Drug-Induced; gamma-Aminobut | 2023 |
Parkinsonism associated with gabapentinoid drugs: A pharmacoepidemiologic study.
Topics: Aged; Bayes Theorem; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Parkins | 2020 |
Dopamine receptor cooperativity synergistically drives dyskinesia, motor behavior, and striatal GABA neurotransmission in hemiparkinsonian rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Corpus Striatum; Dopamine Agoni | 2020 |
GABA storage and release in the medial globus pallidus in L-DOPA-induced dyskinesia priming.
Topics: Animals; Antiparkinson Agents; Dyskinesia, Drug-Induced; gamma-Aminobutyric Acid; Globus Pallidus; L | 2020 |
Striatal and nigral muscarinic type 1 and type 4 receptors modulate levodopa-induced dyskinesia and striato-nigral pathway activation in 6-hydroxydopamine hemilesioned rats.
Topics: Allosteric Regulation; Animals; Dopamine Agents; Dyskinesia, Drug-Induced; gamma-Aminobutyric Acid; | 2020 |
GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model.
Topics: Animals; Astrocytes; Cell Membrane; Corpus Striatum; Disease Models, Animal; Dopamine; Down-Regulati | 2020 |
Activation and blockade of basolateral amygdala 5-HT
Topics: Animals; Anti-Anxiety Agents; Anxiety; Basolateral Nuclear Complex; Corpus Striatum; Dopamine; gamma | 2018 |
Glutamate and GABA neurotransmission are increased in paraventricular nucleus of hypothalamus in rats induced to 6-OHDA parkinsonism: Involvement of nNOS.
Topics: Animals; Blood Pressure; Cardiovascular System; gamma-Aminobutyric Acid; Glutamic Acid; Heart Rate; | 2019 |
Ginsenoside Rb1 regulates prefrontal cortical GABAergic transmission in MPTP-treated mice.
Topics: Animals; Cell Line; gamma-Aminobutyric Acid; Ginsenosides; Humans; Male; Mice; Mice, Inbred C57BL; P | 2019 |
The balance of striatal feedback transmission is disrupted in a model of parkinsonism.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Adrenergic Agents; Anesthetics, Local; Anim | 2013 |
Cellular uptake mechanism and therapeutic utility of a novel peptide in targeted-delivery of proteins into neuronal cells.
Topics: Amino Acid Sequence; Animals; Brain; Cell Line; Drug Delivery Systems; Endocytosis; gamma-Aminobutyr | 2013 |
Effects of the selective adenosine A2A receptor antagonist, SCH 412348, on the parkinsonian phenotype of MitoPark mice.
Topics: Adenosine A2 Receptor Antagonists; Animals; Antiparkinson Agents; Dose-Response Relationship, Drug; | 2014 |
Neurotransmitter receptor density changes in Pitx3ak mice--a model relevant to Parkinson's disease.
Topics: Acetylcholine; Adenosine; Animals; Brain; Dopamine; Epinephrine; gamma-Aminobutyric Acid; Homeodomai | 2015 |
Heterosynaptic regulation of external globus pallidus inputs to the subthalamic nucleus by the motor cortex.
Topics: Animals; Dopamine; GABAergic Neurons; gamma-Aminobutyric Acid; Globus Pallidus; Glutamic Acid; Long- | 2015 |
Striking the right balance: cortical modulation of the subthalamic nucleus-globus pallidus circuit.
Topics: Animals; Dopamine; gamma-Aminobutyric Acid; Globus Pallidus; Glutamic Acid; Motor Cortex; Neural Pat | 2015 |
Interaction between hyperdirect and indirect basal ganglia pathways.
Topics: Animals; Dopamine; gamma-Aminobutyric Acid; Globus Pallidus; Glutamic Acid; Motor Cortex; Neural Pat | 2015 |
Loss of Striatonigral GABAergic Presynaptic Inhibition Enables Motor Sensitization in Parkinsonian Mice.
Topics: Adrenergic Agents; Animals; Bacterial Proteins; Channelrhodopsins; Corpus Striatum; Disease Models, | 2015 |
Frequency-Dependent Corticostriatal Disinhibition Resulting from Chronic Dopamine Depletion: Role of Local Striatal cGMP and GABA-AR Signaling.
Topics: Animals; Brain Waves; Cerebral Cortex; Corpus Striatum; Cyclic GMP; Dopamine; Forelimb; gamma-Aminob | 2017 |
The novel 5-HT1A receptor agonist, NLX-112 reduces l-DOPA-induced abnormal involuntary movements in rat: A chronic administration study with microdialysis measurements.
Topics: Animals; Anti-Dyskinesia Agents; Corpus Striatum; Cross-Over Studies; Dopamine; Dose-Response Relati | 2016 |
The Role of Primary Motor Cortex (M1) Glutamate and GABA Signaling in l-DOPA-Induced Dyskinesia in Parkinsonian Rats.
Topics: Animals; Antiparkinson Agents; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, | 2016 |
Dopaminergic treatment weakens medium spiny neuron collateral inhibition in the parkinsonian striatum.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Female; gamma-Amin | 2017 |
6-OHDA-induced hemiparkinsonism and chronic L-DOPA treatment increase dopamine D1-stimulated [(3)H]-GABA release and [(3)H]-cAMP production in substantia nigra pars reticulata of the rat.
Topics: 1-Methyl-3-isobutylxanthine; Analysis of Variance; Animals; Antiparkinson Agents; Behavior, Animal; | 2008 |
Glutamatergic pallidothalamic projections and their implications in the pathophysiology of Parkinson's disease.
Topics: Animals; Dopamine; Down-Regulation; Efferent Pathways; Entopeduncular Nucleus; gamma-Aminobutyric Ac | 2008 |
Non-dopaminergic neurons in ventral mesencephalic transplants make widespread axonal connections in the host brain.
Topics: Animals; Animals, Newborn; Brain; Brain Tissue Transplantation; Cells, Cultured; Dopamine; Female; g | 2008 |
A multitarget basal ganglia dopaminergic and GABAergic transplantation strategy enhances behavioural recovery in parkinsonian rats.
Topics: Animals; Basal Ganglia; Dopamine; Female; Fetal Stem Cells; gamma-Aminobutyric Acid; Humans; Immunoh | 2008 |
Behavioral recovery in MPTP-treated monkeys: neurochemical mechanisms studied by intrastriatal microdialysis.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Chlorocebus aethiops; Corpus Striatum; Di | 2008 |
The novel nociceptin/orphanin FQ receptor antagonist Trap-101 alleviates experimental parkinsonism through inhibition of the nigro-thalamic pathway: positive interaction with L-DOPA.
Topics: Animals; Antiparkinson Agents; Benzimidazoles; Disease Models, Animal; Dose-Response Relationship, D | 2008 |
Stimulation of delta opioid receptors located in substantia nigra reticulata but not globus pallidus or striatum restores motor activity in 6-hydroxydopamine lesioned rats: new insights into the role of delta receptors in parkinsonism.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzamides; Bicuculline; Bridged Bicyclo Compounds, | 2008 |
Dopamine D1 receptor gene expression studies in unilateral 6-hydroxydopamine-lesioned Parkinson's rat: effect of 5-HT, GABA, and bone marrow cell supplementation.
Topics: Adrenergic Agents; Animals; Bone Marrow Transplantation; Brain; Dopamine; gamma-Aminobutyric Acid; M | 2010 |
The novel delta opioid receptor agonist UFP-512 dually modulates motor activity in hemiparkinsonian rats via control of the nigro-thalamic pathway.
Topics: Amino Acids; Animals; Antiparkinson Agents; Benzimidazoles; Dose-Response Relationship, Drug; gamma- | 2009 |
Vasoactive intestinal peptide (VIP) treatment of Parkinsonian rats increases thalamic gamma-aminobutyric acid (GABA) levels and alters the release of nerve growth factor (NGF) by mast cells.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Female; gamma-Aminobutyric Acid; Heparin; Male; Mast Cells; | 2010 |
Endogenous nociceptin/orphanin FQ (N/OFQ) contributes to haloperidol-induced changes of nigral amino acid transmission and parkinsonism: a combined microdialysis and behavioral study in naïve and nociceptin/orphanin FQ receptor knockout mice.
Topics: Animals; Antipsychotic Agents; Benzimidazoles; Disease Models, Animal; Dose-Response Relationship, D | 2010 |
Changes in firing rate and pattern of GABAergic neurons in subregions of the substantia nigra pars reticulata in rat models of Parkinson's disease.
Topics: Action Potentials; Animals; Cell Count; Disease Models, Animal; gamma-Aminobutyric Acid; Male; Media | 2010 |
L-DOPA-induced dyskinesia in hemiparkinsonian rats is associated with up-regulation of adenylyl cyclase type V/VI and increased GABA release in the substantia nigra reticulata.
Topics: Adenylyl Cyclases; Animals; Dyskinesia, Drug-Induced; Enzyme Inhibitors; gamma-Aminobutyric Acid; Le | 2011 |
Striatal ablation of GABAergic neurons prevents the in vivo neuroprotective effect of DCG-IV against the MPP+-induced neurotoxicity on dopaminergic nerve terminals.
Topics: Animals; Corpus Striatum; Cyclopropanes; Disease Models, Animal; Dopamine; gamma-Aminobutyric Acid; | 2010 |
BL-1023 improves behavior and neuronal survival in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-intoxicated mice.
Topics: Animals; Behavior, Animal; Brain; Cell Survival; Drug Combinations; gamma-Aminobutyric Acid; Immunoh | 2011 |
Striatal origin of the pathologic beta oscillations in Parkinson's disease.
Topics: Action Potentials; Animals; Beta Rhythm; Carbachol; Cholinergic Agonists; Dopamine; gamma-Aminobutyr | 2011 |
Striatal NTS1 , dopamine D2 and NMDA receptor regulation of pallidal GABA and glutamate release--a dual-probe microdialysis study in the intranigral 6-hydroxydopamine unilaterally lesioned rat.
Topics: Adrenergic Agents; Animals; Corpus Striatum; gamma-Aminobutyric Acid; Globus Pallidus; Glutamic Acid | 2012 |
Noisy galvanic vestibular stimulation promotes GABA release in the substantia nigra and improves locomotion in hemiparkinsonian rats.
Topics: Acoustic Stimulation; Animals; Behavior, Animal; Disease Models, Animal; Female; gamma-Aminobutyric | 2012 |
An in vivo ultrahigh field 14.1 T (1) H-MRS study on 6-OHDA and α-synuclein-based rat models of Parkinson's disease: GABA as an early disease marker.
Topics: alpha-Synuclein; Animals; Biomarkers; Brain; Early Diagnosis; Female; gamma-Aminobutyric Acid; Magne | 2013 |
Subthalamic lesion or levodopa treatment rescues giant GABAergic currents of PINK1-deficient striatum.
Topics: Animals; Antiparkinson Agents; Corpus Striatum; Electric Conductivity; Excitatory Amino Acid Agonist | 2012 |
Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat.
Topics: 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic Acid; Animals; Biomarkers; Dopamine; Environm | 2002 |
GABA-opioid interactions in the globus pallidus: [D-Ala2]-Met-enkephalinamide attenuates potassium-evoked GABA release after nigrostriatal lesion.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Behavior, Animal; Cats; Disease Models, Anima | 2002 |
Low cumulative manganese exposure affects striatal GABA but not dopamine.
Topics: Animals; Corpus Striatum; Dopamine; Drug Administration Schedule; Drug Synergism; Environmental Expo | 2002 |
Subthalamic GAD gene therapy in a Parkinson's disease rat model.
Topics: Animals; Dependovirus; Disease Models, Animal; Dopamine; Electric Stimulation; Electrophysiology; ga | 2002 |
Reversal of akinesia in experimental parkinsonism by GABA antagonist microinjections in the pedunculopontine nucleus.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Bicuculline; Cholinergic Fibers; Female; GABA | 2002 |
Stimulation of cannabinoid receptors reduces levodopa-induced dyskinesia in the MPTP-lesioned nonhuman primate model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Benserazide; Callithrix | 2002 |
[Mechanism of nootropic digam action in hypofunction of brain dopaminergic system].
Topics: Animals; Caudate Nucleus; Dopamine Antagonists; GABA Agents; gamma-Aminobutyric Acid; Haloperidol; N | 2003 |
Adenosinergic protection of dopaminergic and GABAergic neurons against mitochondrial inhibition through receptors located in the substantia nigra and striatum, respectively.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Animals; Corpus Str | 2003 |
Neurochemical mechanisms induced by high frequency stimulation of the subthalamic nucleus: increase of extracellular striatal glutamate and GABA in normal and hemiparkinsonian rats.
Topics: Animals; Corpus Striatum; Electric Stimulation; Extracellular Fluid; gamma-Aminobutyric Acid; Glutam | 2003 |
L-DOPA-induced modulation of GABA and glutamate release in substantia nigra pars reticulata in a rodent model of Parkinson's disease.
Topics: Animals; gamma-Aminobutyric Acid; Glutamic Acid; Levodopa; Male; Oxidopamine; Parkinsonian Disorders | 2004 |
Adenosine A(2A) receptor-mediated modulation of GABA and glutamate release in the output regions of the basal ganglia in a rodent model of Parkinson's disease.
Topics: Adenosine A2 Receptor Antagonists; Animals; Basal Ganglia; Denervation; Disease Models, Animal; Effe | 2004 |
Expression of GAD65 and GAD67 immunoreactivity in MPTP-treated monkeys with or without L-DOPA administration.
Topics: Animals; Basal Ganglia; Cell Count; Cerebral Cortex; Disease Models, Animal; Dopamine Agents; gamma- | 2005 |
Synaptic microcircuitry of tyrosine hydroxylase-containing neurons and terminals in the striatum of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys.
Topics: Animals; Corpus Striatum; gamma-Aminobutyric Acid; Image Processing, Computer-Assisted; Macaca mulat | 2006 |
Cortical inputs and GABA interneurons imbalance projection neurons in the striatum of parkinsonian rats.
Topics: Animals; Cerebral Cortex; Corpus Striatum; gamma-Aminobutyric Acid; Interneurons; Neural Pathways; P | 2006 |
Adult human bone marrow stromal spheres express neuronal traits in vitro and in a rat model of Parkinson's disease.
Topics: Animals; Biomarkers; Bone Marrow Transplantation; Cell Death; Cell Differentiation; Cell Line; Cells | 2006 |
Subchronic administration of L-DOPA to adult rats with a unilateral 6-hydroxydopamine lesion of dopamine neurons results in a sensitization of enhanced GABA release in the substantia nigra, pars reticulata.
Topics: Animals; Antiparkinson Agents; Dopamine; Dopamine Agents; Drug Administration Schedule; gamma-Aminob | 2006 |
Unilateral 6-hydroxydopamine lesion of dopamine neurons and subchronic L-DOPA administration in the adult rat alters the expression of the vesicular GABA transporter in different subsets of striatal neurons and in the substantia nigra, pars reticulata.
Topics: Animals; Antiparkinson Agents; Corpus Striatum; Dopamine; Down-Regulation; Drug Administration Sched | 2007 |
The nociceptin/orphanin FQ receptor antagonist J-113397 and L-DOPA additively attenuate experimental parkinsonism through overinhibition of the nigrothalamic pathway.
Topics: Animals; Antiparkinson Agents; Benzimidazoles; Bicuculline; Drug Synergism; Drug Therapy, Combinatio | 2007 |
Interleukin-1beta mediates sleep alteration in rats with rotenone-induced parkinsonism.
Topics: Animals; Arousal; Brain; Brain Mapping; Dopamine; gamma-Aminobutyric Acid; Interleukin-1beta; Male; | 2007 |
Basal ganglia neurotransmitter concentrations in rhesus monkeys following subchronic manganese sulfate inhalation.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Basal Ganglia; Disease Models, Animal; Dopamine; gamma-Amin | 2007 |
Metabolic changes detected by proton magnetic resonance spectroscopy in vivo and in vitro in a murin model of Parkinson's disease, the MPTP-intoxicated mouse.
Topics: Animals; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Dopamine; gamma-Aminobutyric Acid | 2008 |
Behavioral and biochemical correlates of the dyskinetic potential of dopaminergic agonists in the 6-OHDA lesioned rat.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antiparkinson Agents; Corpus St | 2008 |
Intrapallidal dopamine restores motor deficits induced by 6-hydroxydopamine in the rat.
Topics: Animals; Apomorphine; Benzazepines; Dopamine; Dopamine Agonists; Dopamine Antagonists; gamma-Aminobu | 2001 |
Effect of microiontophoretic application of dopamine on subthalamic nucleus neuronal activity in normal rats and in rats with unilateral lesion of the nigrostriatal pathway.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Action Potentials; Animals; Apomorphine; | 2001 |