gamma-aminobutyric acid has been researched along with Paraplegia in 14 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
Paraplegia: Severe or complete loss of motor function in the lower extremities and lower portions of the trunk. This condition is most often associated with SPINAL CORD DISEASES, although BRAIN DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; NEUROMUSCULAR DISEASES; and MUSCULAR DISEASES may also cause bilateral leg weakness.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To report a case of paraplegia with limb edema caused by pregabalin." | 7.78 | Reversible post-pregabalin peripheral edema in a spinal cord injury patient. ( Duman, I; Guzelkucuk, U; Tan, AK; Yılmaz, B, 2012) |
| "Pregabalin, which is one of medications used for neuropathic pain, might cause limb edema, that is, a condition needs differential diagnosis." | 7.78 | Reversible post-pregabalin peripheral edema in a spinal cord injury patient. ( Duman, I; Guzelkucuk, U; Tan, AK; Yılmaz, B, 2012) |
| " Right hemichorea developed and was related to adjunctive therapy with gabapentin." | 7.74 | Hemichorea associated with gabapentin therapy with hypoperfusion in contralateral basal ganglion - a case of a paraplegic patient with neuropathic pain. ( Chang, CC; Chang, ST; Lai, MH; Tsai, KC; Wang, TY, 2008) |
| "To present two years of experience in the use of gabapentin for the alleviation of neuropathic pain in spinal cord injury patients." | 7.71 | Gabapentin for neuropathic pain following spinal cord injury. ( Brown, DJ; Cooper, N; Frauman, AG; Hill, ST; Kirsa, SW; Lim, TC; To, TP, 2002) |
| "Data were retrieved from the medical records of all spinal cord injury patients prescribed gabapentin for neuropathic pain." | 7.71 | Gabapentin for neuropathic pain following spinal cord injury. ( Brown, DJ; Cooper, N; Frauman, AG; Hill, ST; Kirsa, SW; Lim, TC; To, TP, 2002) |
| "Seventy-six per cent of patients receiving gabapentin reported a reduction in neuropathic pain." | 7.71 | Gabapentin for neuropathic pain following spinal cord injury. ( Brown, DJ; Cooper, N; Frauman, AG; Hill, ST; Kirsa, SW; Lim, TC; To, TP, 2002) |
| "Our experience suggests that gabapentin offers an effective therapeutic alternative for the alleviation of neuropathic pain following spinal cord injury." | 7.71 | Gabapentin for neuropathic pain following spinal cord injury. ( Brown, DJ; Cooper, N; Frauman, AG; Hill, ST; Kirsa, SW; Lim, TC; To, TP, 2002) |
| "The edema was considered to be caused by pregabalin and the medicine was ceased gradually." | 5.38 | Reversible post-pregabalin peripheral edema in a spinal cord injury patient. ( Duman, I; Guzelkucuk, U; Tan, AK; Yılmaz, B, 2012) |
| "Our patient is the first patient with neuropathic pain, treated with gabapentin who developed hemichorea, in the absence of brain lesions." | 5.35 | Hemichorea associated with gabapentin therapy with hypoperfusion in contralateral basal ganglion - a case of a paraplegic patient with neuropathic pain. ( Chang, CC; Chang, ST; Lai, MH; Tsai, KC; Wang, TY, 2008) |
| "Pain was assessed prior to and during treatment at 1, 3 and 6 months with a 10 cm visual analogue scale which ranged from 0 ('no pain') to 10 ('worst pain imaginable'), or by the documentation of a verbal description of pain." | 5.31 | Gabapentin for neuropathic pain following spinal cord injury. ( Brown, DJ; Cooper, N; Frauman, AG; Hill, ST; Kirsa, SW; Lim, TC; To, TP, 2002) |
| "To report a case of paraplegia with limb edema caused by pregabalin." | 3.78 | Reversible post-pregabalin peripheral edema in a spinal cord injury patient. ( Duman, I; Guzelkucuk, U; Tan, AK; Yılmaz, B, 2012) |
| "Pregabalin, which is one of medications used for neuropathic pain, might cause limb edema, that is, a condition needs differential diagnosis." | 3.78 | Reversible post-pregabalin peripheral edema in a spinal cord injury patient. ( Duman, I; Guzelkucuk, U; Tan, AK; Yılmaz, B, 2012) |
| " Right hemichorea developed and was related to adjunctive therapy with gabapentin." | 3.74 | Hemichorea associated with gabapentin therapy with hypoperfusion in contralateral basal ganglion - a case of a paraplegic patient with neuropathic pain. ( Chang, CC; Chang, ST; Lai, MH; Tsai, KC; Wang, TY, 2008) |
| "To present two years of experience in the use of gabapentin for the alleviation of neuropathic pain in spinal cord injury patients." | 3.71 | Gabapentin for neuropathic pain following spinal cord injury. ( Brown, DJ; Cooper, N; Frauman, AG; Hill, ST; Kirsa, SW; Lim, TC; To, TP, 2002) |
| "Data were retrieved from the medical records of all spinal cord injury patients prescribed gabapentin for neuropathic pain." | 3.71 | Gabapentin for neuropathic pain following spinal cord injury. ( Brown, DJ; Cooper, N; Frauman, AG; Hill, ST; Kirsa, SW; Lim, TC; To, TP, 2002) |
| "Seventy-six per cent of patients receiving gabapentin reported a reduction in neuropathic pain." | 3.71 | Gabapentin for neuropathic pain following spinal cord injury. ( Brown, DJ; Cooper, N; Frauman, AG; Hill, ST; Kirsa, SW; Lim, TC; To, TP, 2002) |
| "Our experience suggests that gabapentin offers an effective therapeutic alternative for the alleviation of neuropathic pain following spinal cord injury." | 3.71 | Gabapentin for neuropathic pain following spinal cord injury. ( Brown, DJ; Cooper, N; Frauman, AG; Hill, ST; Kirsa, SW; Lim, TC; To, TP, 2002) |
| "Robust allodynia was observed in all three ligation groups." | 1.42 | Ligation of mouse L4 and L5 spinal nerves produces robust allodynia without major motor function deficit. ( Baker, KB; Lanthorn, TH; Mason, S; Rajan, I; Savelieva, KV; Vogel, P; Ye, GL, 2015) |
| "The edema was considered to be caused by pregabalin and the medicine was ceased gradually." | 1.38 | Reversible post-pregabalin peripheral edema in a spinal cord injury patient. ( Duman, I; Guzelkucuk, U; Tan, AK; Yılmaz, B, 2012) |
| "Our patient is the first patient with neuropathic pain, treated with gabapentin who developed hemichorea, in the absence of brain lesions." | 1.35 | Hemichorea associated with gabapentin therapy with hypoperfusion in contralateral basal ganglion - a case of a paraplegic patient with neuropathic pain. ( Chang, CC; Chang, ST; Lai, MH; Tsai, KC; Wang, TY, 2008) |
| " In addition the optimal time frame for cell grafting after ischemia and the optimal dosing of grafted cells were also studied." | 1.34 | Functional recovery in rats with ischemic paraplegia after spinal grafting of human spinal stem cells. ( Cizkova, D; Hazel, T; Hefferan, MP; Johe, K; Kakinohana, O; Kucharova, K; Marsala, M; Marsala, S, 2007) |
| "Transient spinal cord ischemia in humans can lead to the development of permanent paraplegia with prominent spasticity and rigidity." | 1.34 | Functional recovery in rats with ischemic paraplegia after spinal grafting of human spinal stem cells. ( Cizkova, D; Hazel, T; Hefferan, MP; Johe, K; Kakinohana, O; Kucharova, K; Marsala, M; Marsala, S, 2007) |
| "Spinal cord ischemia was induced for 10 min using aortic occlusion and systemic hypotension." | 1.34 | Functional recovery in rats with ischemic paraplegia after spinal grafting of human spinal stem cells. ( Cizkova, D; Hazel, T; Hefferan, MP; Johe, K; Kakinohana, O; Kucharova, K; Marsala, M; Marsala, S, 2007) |
| "Pain was assessed prior to and during treatment at 1, 3 and 6 months with a 10 cm visual analogue scale which ranged from 0 ('no pain') to 10 ('worst pain imaginable'), or by the documentation of a verbal description of pain." | 1.31 | Gabapentin for neuropathic pain following spinal cord injury. ( Brown, DJ; Cooper, N; Frauman, AG; Hill, ST; Kirsa, SW; Lim, TC; To, TP, 2002) |
| "Although somatic msucular spasticity appears to be, to some extent, due to GABA dysfunction in the spinal cord, alterations in "normal" functioning of other neurotransmitters and the loss of supraspinal control also contribute to this state." | 1.26 | Correlation of changes in the GABA-ergic system with the development of spasticity in paraplegic cats. ( Horst, WD; Naftchi, NE; Schlosser, W, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (28.57) | 29.6817 |
| 2010's | 3 (21.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ye, GL | 1 |
| Savelieva, KV | 1 |
| Vogel, P | 1 |
| Baker, KB | 1 |
| Mason, S | 1 |
| Lanthorn, TH | 1 |
| Rajan, I | 1 |
| Guzelkucuk, U | 1 |
| Duman, I | 1 |
| Yılmaz, B | 1 |
| Tan, AK | 1 |
| Loutochin, O | 1 |
| Al Afraa, T | 1 |
| Campeau, L | 1 |
| Mahfouz, W | 1 |
| Elzayat, E | 1 |
| Corcos, J | 1 |
| Marsala, M | 2 |
| Kakinohana, O | 2 |
| Yaksh, TL | 1 |
| Tomori, Z | 1 |
| Marsala, S | 2 |
| Cizkova, D | 2 |
| Kucharova, K | 1 |
| Johe, K | 1 |
| Hazel, T | 1 |
| Hefferan, MP | 1 |
| Lai, MH | 1 |
| Wang, TY | 1 |
| Chang, CC | 1 |
| Tsai, KC | 1 |
| Chang, ST | 1 |
| McBride, WJ | 1 |
| Hall, PV | 1 |
| Chernet, E | 1 |
| Patrick, JT | 1 |
| Shapiro, S | 1 |
| To, TP | 1 |
| Lim, TC | 1 |
| Hill, ST | 1 |
| Frauman, AG | 1 |
| Cooper, N | 1 |
| Kirsa, SW | 1 |
| Brown, DJ | 1 |
| Naftchi, NE | 1 |
| Schlosser, W | 1 |
| Horst, WD | 1 |
| Haubensak, K | 1 |
| Blümlein, H | 1 |
| Robinson, GA | 1 |
| Goldberger, ME | 1 |
| Basmajian, JV | 1 |
| Yucel, V | 1 |
| Knutsson, E | 1 |
| Lindblom, U | 1 |
| Mårtensson, A | 1 |
| Sazonova, NS | 1 |
| Balashova, EG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Use of Penile Vibratory Stimulation to Decrease Spasticity Following Spinal Cord Injury[NCT00223873] | 30 participants | Interventional | 2002-11-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for gamma-aminobutyric acid and Paraplegia
| Article | Year |
|---|---|
[Treatment of the neurogenic detrusor-sphincter dyssynergy with lioresal].
Topics: Adult; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Paraplegia; Urinary Bladder, Neurogenic; | 1978 |
Effects of a GABA--derivative (BA-34647) on spasticity. Preliminary report of a double-blind cross-over study.
Topics: Administration, Oral; Adult; Aminobutyrates; Clinical Trials as Topic; Electromyography; Female; gam | 1974 |
12 other studies available for gamma-aminobutyric acid and Paraplegia
| Article | Year |
|---|---|
Ligation of mouse L4 and L5 spinal nerves produces robust allodynia without major motor function deficit.
Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Female; Gabapentin; gamma-Amin | 2015 |
Reversible post-pregabalin peripheral edema in a spinal cord injury patient.
Topics: Adult; Analgesics; Edema; gamma-Aminobutyric Acid; Humans; Lower Extremity; Male; Neuralgia; Paraple | 2012 |
Effect of the anticonvulsant medications pregabalin and lamotrigine on urodynamic parameters in an animal model of neurogenic detrusor overactivity.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Female; gamma-Am | 2012 |
Spinal implantation of hNT neurons and neuronal precursors: graft survival and functional effects in rats with ischemic spastic paraplegia.
Topics: Animals; Animals, Newborn; Biomarkers; Cells, Cultured; Coculture Techniques; Disease Models, Animal | 2004 |
Functional recovery in rats with ischemic paraplegia after spinal grafting of human spinal stem cells.
Topics: Adult; Animals; Astrocytes; Cell Proliferation; Cell Survival; Cells, Cultured; Evoked Potentials, M | 2007 |
Hemichorea associated with gabapentin therapy with hypoperfusion in contralateral basal ganglion - a case of a paraplegic patient with neuropathic pain.
Topics: Adult; Amines; Analgesics; Basal Ganglia; Cerebrovascular Circulation; Chorea; Cyclohexanecarboxylic | 2008 |
Alterations of amino acid transmitter systems in spinal cords of chronic paraplegic dogs.
Topics: Animals; Biological Transport; Dogs; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Kin | 1984 |
Gabapentin for neuropathic pain following spinal cord injury.
Topics: Acetates; Acute Disease; Adolescent; Adult; Aged; Amines; Chronic Disease; Cyclohexanecarboxylic Aci | 2002 |
Correlation of changes in the GABA-ergic system with the development of spasticity in paraplegic cats.
Topics: Afferent Pathways; Animals; Cats; Female; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Kinetics | 1979 |
Interfering with inhibition may improve motor function.
Topics: Age Factors; Animals; Animals, Newborn; Bicuculline; Cats; gamma-Aminobutyric Acid; Neural Inhibitio | 1985 |
Plasma and cerebrospinal fluid levels of baclofen (Lioresal) at optimal therapeutic responses in spastic paresis.
Topics: Adolescent; Adult; Aged; Aminobutyrates; Cold Temperature; Female; gamma-Aminobutyric Acid; Humans; | 1974 |
[Experience with clinical use of the drug gammalon in children with cerebral palsy].
Topics: Adolescent; Aminobutyrates; Cerebral Palsy; Child; Child, Preschool; Electromyography; Feeding and E | 1974 |