gamma-aminobutyric acid has been researched along with Pancreatitis, Chronic in 7 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
Pancreatitis, Chronic: INFLAMMATION of the PANCREAS that is characterized by recurring or persistent ABDOMINAL PAIN with or without STEATORRHEA or DIABETES MELLITUS. It is characterized by the irregular destruction of the pancreatic parenchyma which may be focal, segmental, or diffuse.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To identify electroencephalographic (EEG) biomarkers for the analgesic effect of pregabalin in patients with chronic visceral pain." | 9.16 | The analgesic effect of pregabalin in patients with chronic pain is reflected by changes in pharmaco-EEG spectral indices. ( Bouwense, SA; Drewes, AM; Farina, D; Graversen, C; Olesen, AE; Olesen, SS; Steimle, K; van Goor, H; Wilder-Smith, OH, 2012) |
| "It was recently shown that pregabalin decreased pain associated with chronic pancreatitis." | 9.16 | The absorption profile of pregabalin in chronic pancreatitis. ( Andresen, T; Dahan, A; Drewes, AM; Olesen, AE; Olesen, SS; Olofsen, E; Staahl, C, 2012) |
| "Our study provides first evidence that pregabalin has moderate inhibitory effects on central sensitization manifest as spreading hyperalgesia in chronic pancreatitis patients." | 9.16 | Effects of pregabalin on central sensitization in patients with chronic pancreatitis in a randomized, controlled trial. ( Bouwense, SA; Drewes, AM; Olesen, SS; Poley, JW; van Goor, H; Wilder-Smith, OH, 2012) |
| "To assess the antinociceptive effect of pregabalin on experimental gut pain in patients with visceral hyperalgesia due to chronic pancreatitis and to reveal putative changes in corresponding central pain processing as assessed by evoked brain potentials." | 9.15 | Randomised clinical trial: pregabalin attenuates experimental visceral pain through sub-cortical mechanisms in patients with painful chronic pancreatitis. ( Drewes, AM; Frøkjaer, JB; Graversen, C; Olesen, AE; Olesen, SS; Valeriani, M; van Goor, H; Wilder-Smith, O, 2011) |
| "Pregabalin was superior to placebo for attenuation of experimental visceral pain in chronic pancreatitis patients." | 9.15 | Randomised clinical trial: pregabalin attenuates experimental visceral pain through sub-cortical mechanisms in patients with painful chronic pancreatitis. ( Drewes, AM; Frøkjaer, JB; Graversen, C; Olesen, AE; Olesen, SS; Valeriani, M; van Goor, H; Wilder-Smith, O, 2011) |
| " We tested the ability of quantitative sensory testing to predict the analgesic effect of pregabalin and placebo in patients with chronic pancreatitis." | 7.79 | Quantitative sensory testing predicts pregabalin efficacy in painful chronic pancreatitis. ( Bouwense, SA; Drewes, AM; Graversen, C; Olesen, SS; van Goor, H; Wilder-Smith, OH, 2013) |
| "Sixty-four patients with painful chronic pancreatitis received pregabalin (150-300 mg BID) or matching placebo for three consecutive weeks." | 7.79 | Quantitative sensory testing predicts pregabalin efficacy in painful chronic pancreatitis. ( Bouwense, SA; Drewes, AM; Graversen, C; Olesen, SS; van Goor, H; Wilder-Smith, OH, 2013) |
| "The present study provides first evidence that quantitative sensory testing predicts the analgesic effect of pregabalin in patients with painful chronic pancreatitis." | 7.79 | Quantitative sensory testing predicts pregabalin efficacy in painful chronic pancreatitis. ( Bouwense, SA; Drewes, AM; Graversen, C; Olesen, SS; van Goor, H; Wilder-Smith, OH, 2013) |
| "Gabapentin, an anticonvulsant, is widely accepted as an alternative therapeutic agent for neuropathic pain and has proved to produce analgesic effects in a mouse model of visceral pain." | 7.76 | Analgesic effects of gabapentin on mechanical hypersensitivity in a rat model of chronic pancreatitis. ( Chen, H; Liao, XZ; Mao, YF; Sun, JH; Xiong, YC; Xu, H; Zhou, MT, 2010) |
| " Pregabalin is well absorbed in patients with chronic pancreatitis, and the pharmacokinetic profile of pregabalin is not extensively affected by chronic pancreatitis." | 6.77 | The absorption profile of pregabalin in chronic pancreatitis. ( Andresen, T; Dahan, A; Drewes, AM; Olesen, AE; Olesen, SS; Olofsen, E; Staahl, C, 2012) |
| "To identify electroencephalographic (EEG) biomarkers for the analgesic effect of pregabalin in patients with chronic visceral pain." | 5.16 | The analgesic effect of pregabalin in patients with chronic pain is reflected by changes in pharmaco-EEG spectral indices. ( Bouwense, SA; Drewes, AM; Farina, D; Graversen, C; Olesen, AE; Olesen, SS; Steimle, K; van Goor, H; Wilder-Smith, OH, 2012) |
| "It was recently shown that pregabalin decreased pain associated with chronic pancreatitis." | 5.16 | The absorption profile of pregabalin in chronic pancreatitis. ( Andresen, T; Dahan, A; Drewes, AM; Olesen, AE; Olesen, SS; Olofsen, E; Staahl, C, 2012) |
| "Our study provides first evidence that pregabalin has moderate inhibitory effects on central sensitization manifest as spreading hyperalgesia in chronic pancreatitis patients." | 5.16 | Effects of pregabalin on central sensitization in patients with chronic pancreatitis in a randomized, controlled trial. ( Bouwense, SA; Drewes, AM; Olesen, SS; Poley, JW; van Goor, H; Wilder-Smith, OH, 2012) |
| "To assess the antinociceptive effect of pregabalin on experimental gut pain in patients with visceral hyperalgesia due to chronic pancreatitis and to reveal putative changes in corresponding central pain processing as assessed by evoked brain potentials." | 5.15 | Randomised clinical trial: pregabalin attenuates experimental visceral pain through sub-cortical mechanisms in patients with painful chronic pancreatitis. ( Drewes, AM; Frøkjaer, JB; Graversen, C; Olesen, AE; Olesen, SS; Valeriani, M; van Goor, H; Wilder-Smith, O, 2011) |
| "Pregabalin was superior to placebo for attenuation of experimental visceral pain in chronic pancreatitis patients." | 5.15 | Randomised clinical trial: pregabalin attenuates experimental visceral pain through sub-cortical mechanisms in patients with painful chronic pancreatitis. ( Drewes, AM; Frøkjaer, JB; Graversen, C; Olesen, AE; Olesen, SS; Valeriani, M; van Goor, H; Wilder-Smith, O, 2011) |
| " We tested the ability of quantitative sensory testing to predict the analgesic effect of pregabalin and placebo in patients with chronic pancreatitis." | 3.79 | Quantitative sensory testing predicts pregabalin efficacy in painful chronic pancreatitis. ( Bouwense, SA; Drewes, AM; Graversen, C; Olesen, SS; van Goor, H; Wilder-Smith, OH, 2013) |
| "Sixty-four patients with painful chronic pancreatitis received pregabalin (150-300 mg BID) or matching placebo for three consecutive weeks." | 3.79 | Quantitative sensory testing predicts pregabalin efficacy in painful chronic pancreatitis. ( Bouwense, SA; Drewes, AM; Graversen, C; Olesen, SS; van Goor, H; Wilder-Smith, OH, 2013) |
| "The present study provides first evidence that quantitative sensory testing predicts the analgesic effect of pregabalin in patients with painful chronic pancreatitis." | 3.79 | Quantitative sensory testing predicts pregabalin efficacy in painful chronic pancreatitis. ( Bouwense, SA; Drewes, AM; Graversen, C; Olesen, SS; van Goor, H; Wilder-Smith, OH, 2013) |
| "Gabapentin, an anticonvulsant, is widely accepted as an alternative therapeutic agent for neuropathic pain and has proved to produce analgesic effects in a mouse model of visceral pain." | 3.76 | Analgesic effects of gabapentin on mechanical hypersensitivity in a rat model of chronic pancreatitis. ( Chen, H; Liao, XZ; Mao, YF; Sun, JH; Xiong, YC; Xu, H; Zhou, MT, 2010) |
| " Pregabalin is well absorbed in patients with chronic pancreatitis, and the pharmacokinetic profile of pregabalin is not extensively affected by chronic pancreatitis." | 2.77 | The absorption profile of pregabalin in chronic pancreatitis. ( Andresen, T; Dahan, A; Drewes, AM; Olesen, AE; Olesen, SS; Olofsen, E; Staahl, C, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Olesen, SS | 6 |
| Graversen, C | 3 |
| Bouwense, SA | 4 |
| van Goor, H | 5 |
| Wilder-Smith, OH | 4 |
| Drewes, AM | 6 |
| Liao, XZ | 1 |
| Zhou, MT | 1 |
| Mao, YF | 1 |
| Xu, H | 1 |
| Chen, H | 1 |
| Sun, JH | 1 |
| Xiong, YC | 1 |
| Olesen, AE | 3 |
| Frøkjaer, JB | 1 |
| Wilder-Smith, O | 1 |
| Valeriani, M | 1 |
| Steimle, K | 1 |
| Farina, D | 1 |
| Olofsen, E | 1 |
| Staahl, C | 1 |
| Andresen, T | 1 |
| Dahan, A | 1 |
| Poley, JW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Impact of Personalized Education on Pain Response in Patients With Chronic Pancreatitis (PEPCP)[NCT04654377] | 140 participants (Anticipated) | Interventional | 2021-06-29 | Recruiting | |||
| Evaluation of Efficacy of Combination of Pregabalin and Antioxidant in Reducing Pain in Chronic Pancreatitis: a RCT[NCT01528540] | 87 participants (Actual) | Interventional | 2012-04-30 | Completed | |||
| A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Clinical and Experimental Pilot Study of Pregabalin in Patients With Chronic Pancreatitis[NCT00755573] | Phase 2/Phase 3 | 64 participants (Actual) | Interventional | 2008-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 trials available for gamma-aminobutyric acid and Pancreatitis, Chronic
| Article | Year |
|---|---|
Pregabalin reduces pain in patients with chronic pancreatitis in a randomized, controlled trial.
Topics: Abdominal Pain; Adult; Aged; Analgesics; Double-Blind Method; Female; gamma-Aminobutyric Acid; Healt | 2011 |
Pregabalin reduces pain in patients with chronic pancreatitis in a randomized, controlled trial.
Topics: Abdominal Pain; Adult; Aged; Analgesics; Double-Blind Method; Female; gamma-Aminobutyric Acid; Healt | 2011 |
Pregabalin reduces pain in patients with chronic pancreatitis in a randomized, controlled trial.
Topics: Abdominal Pain; Adult; Aged; Analgesics; Double-Blind Method; Female; gamma-Aminobutyric Acid; Healt | 2011 |
Pregabalin reduces pain in patients with chronic pancreatitis in a randomized, controlled trial.
Topics: Abdominal Pain; Adult; Aged; Analgesics; Double-Blind Method; Female; gamma-Aminobutyric Acid; Healt | 2011 |
Randomised clinical trial: pregabalin attenuates experimental visceral pain through sub-cortical mechanisms in patients with painful chronic pancreatitis.
Topics: Adult; Aged; Analgesics; Brain Mapping; Cerebral Cortex; Double-Blind Method; Electric Stimulation; | 2011 |
The analgesic effect of pregabalin in patients with chronic pain is reflected by changes in pharmaco-EEG spectral indices.
Topics: Adult; Analgesics; Chronic Pain; Dose-Response Relationship, Drug; Double-Blind Method; Electroencep | 2012 |
The absorption profile of pregabalin in chronic pancreatitis.
Topics: Absorption; Adolescent; Adult; Aged; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Ac | 2012 |
Effects of pregabalin on central sensitization in patients with chronic pancreatitis in a randomized, controlled trial.
Topics: Analgesics; Case-Control Studies; Central Nervous System Sensitization; Female; gamma-Aminobutyric A | 2012 |
2 other studies available for gamma-aminobutyric acid and Pancreatitis, Chronic
| Article | Year |
|---|---|
Quantitative sensory testing predicts pregabalin efficacy in painful chronic pancreatitis.
Topics: Adult; Analgesics; Electric Stimulation; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; | 2013 |
Analgesic effects of gabapentin on mechanical hypersensitivity in a rat model of chronic pancreatitis.
Topics: Amines; Analgesics; Animals; Calcium Channels; Calcium Channels, L-Type; Cyclohexanecarboxylic Acids | 2010 |