gamma-aminobutyric acid has been researched along with Pancreatic Neoplasms in 26 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine the role of gamma-aminobutyric acid (GABA) in islet tissue, sodium valproate (1600 mg/day) was administered for 6 days to 10 normal subjects and 1 patient with a somatostatinoma." | 5.06 | The effects of sodium valproate on plasma somatostatin and insulin in humans. ( Fujita, S; Ichii, S; Kusunoki, M; Nakai, T; Utsunomiya, J; Yamamura, T, 1988) |
| "A 54-year-old woman was undergoing chemotherapy with gemcitabine and oxaliplatin (GEMOX) for stage II-B pancreatic adenocarcinoma." | 3.74 | Successful amelioration of oxaliplatin-induced hyperexcitability syndrome with the antiepileptic pregabalin in a patient with pancreatic cancer. ( Hashmi, S; Saif, MW, 2008) |
| " Male Wistar rats fed with 2% gabapentin (1-(aminomethyl)cyclohexane acetic acid) in diet for 2 years developed pancreatic exocrine adenomas and adenocarcinomas." | 3.69 | Absence of Ki-ras mutations in exocrine pancreatic tumors from male rats chronically exposed to gabapentin. ( de la Iglesia, FA; Fowler, ML; Lalwani, ND; Reddy, JK; Sigler, RE, 1995) |
| "ECLIPSE (Evaluation of Chronic obstructive pulmonary disease to Longitudinally Identify Predictive Surrogate Endpoints) aims to identify biomarkers that correlate with clinically relevant COPD subtypes, and to assess how these may predict disease progression." | 2.77 | Targeted metabolomics identifies perturbations in amino acid metabolism that sub-classify patients with COPD. ( Cheng, KK; Connor, SC; Dong, J; Griffin, JL; Janowitz, T; Jodrell, D; Lomas, DA; MacNee, W; Riley, JH; Tal-Singer, R; Ubhi, BK, 2012) |
| "Pancreatic cancer is the fourth leading cause of cancer mortality in western countries." | 2.47 | GABA (γ-aminobutyric acid), a non-protein amino acid counters the β-adrenergic cascade-activated oncogenic signaling in pancreatic cancer: a review of experimental evidence. ( Al-Wadei, HA; Al-Wadei, M; Ullah, MF, 2011) |
| "A small subpopulation of pancreatic cancer cells with characteristics of stem cells drive tumour initiation, progression and metastasis." | 1.43 | Nicotine induces self-renewal of pancreatic cancer stem cells via neurotransmitter-driven activation of sonic hedgehog signalling. ( Al-Wadei, HA; Al-Wadei, MH; Banerjee, J; Schuller, HM, 2016) |
| "Pancreatic cancer has a high mortality rate and alcoholism is a risk factor independent of smoking." | 1.39 | Gamma-amino butyric acid (GABA) prevents the induction of nicotinic receptor-regulated signaling by chronic ethanol in pancreatic cancer cells and normal duct epithelia. ( Al-Wadei, HA; Al-Wadei, MH; Schuller, HM, 2013) |
| "Pancreatic cancer has a poor prognosis and is associated with high levels of psychological stress that may adversely affect clinical outcomes." | 1.38 | Regulation of pancreatic cancer by neuropsychological stress responses: a novel target for intervention. ( Al-Wadei, HA; Plummer, HK; Schuller, HM; Ullah, MF, 2012) |
| " In addition to reassurance, pregabalin was prescribed for these myotonic symptoms at a dosage of 50 mg by mouth three times daily." | 1.35 | Successful amelioration of oxaliplatin-induced hyperexcitability syndrome with the antiepileptic pregabalin in a patient with pancreatic cancer. ( Hashmi, S; Saif, MW, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (7.69) | 18.7374 |
| 1990's | 6 (23.08) | 18.2507 |
| 2000's | 9 (34.62) | 29.6817 |
| 2010's | 9 (34.62) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jiang, SH | 1 |
| Zhu, LL | 1 |
| Zhang, M | 1 |
| Li, RK | 1 |
| Yang, Q | 1 |
| Yan, JY | 1 |
| Zhang, C | 1 |
| Yang, JY | 1 |
| Dong, FY | 1 |
| Dai, M | 1 |
| Hu, LP | 1 |
| Li, J | 1 |
| Li, Q | 1 |
| Wang, YH | 1 |
| Yang, XM | 1 |
| Zhang, YL | 1 |
| Nie, HZ | 1 |
| Zhu, L | 1 |
| Zhang, XL | 1 |
| Tian, GA | 1 |
| Zhang, XX | 1 |
| Cao, XY | 1 |
| Tao, LY | 1 |
| Huang, S | 1 |
| Jiang, YS | 1 |
| Hua, R | 1 |
| Qian Luo, K | 1 |
| Gu, JR | 1 |
| Sun, YW | 1 |
| Hou, S | 1 |
| Zhang, ZG | 1 |
| Takahashi, T | 1 |
| Ichikawa, H | 1 |
| Morimoto, Y | 1 |
| Tsuneyama, K | 1 |
| Hijikata, T | 1 |
| Al-Wadei, MH | 4 |
| Banerjee, J | 1 |
| Al-Wadei, HA | 9 |
| Schuller, HM | 8 |
| Plummer, HK | 2 |
| Saadati, H | 1 |
| Saif, MW | 2 |
| Al-Salam, S | 1 |
| Hameed, R | 1 |
| Parvez, HS | 1 |
| Adeghate, E | 1 |
| Ullah, MF | 3 |
| Al-Wadei, M | 1 |
| Ubhi, BK | 1 |
| Cheng, KK | 1 |
| Dong, J | 1 |
| Janowitz, T | 1 |
| Jodrell, D | 1 |
| Tal-Singer, R | 1 |
| MacNee, W | 1 |
| Lomas, DA | 1 |
| Riley, JH | 1 |
| Griffin, JL | 1 |
| Connor, SC | 1 |
| Pelham, A | 1 |
| Lee, MA | 1 |
| Regnard, CB | 1 |
| Porzio, G | 1 |
| Aielli, F | 1 |
| Narducci, F | 1 |
| Varrassi, G | 1 |
| Ricevuto, E | 1 |
| Ficorella, C | 1 |
| Marchetti, P | 1 |
| Hashmi, S | 1 |
| Takehara, A | 1 |
| Hosokawa, M | 1 |
| Eguchi, H | 1 |
| Ohigashi, H | 1 |
| Ishikawa, O | 1 |
| Nakamura, Y | 1 |
| Nakagawa, H | 1 |
| Majidi, M | 1 |
| Sigler, RE | 2 |
| Gough, AW | 1 |
| de la Iglesia, FA | 2 |
| Fowler, ML | 1 |
| Reddy, JK | 1 |
| Lalwani, ND | 1 |
| Rosewicz, S | 1 |
| Ahnert-Hilger, G | 2 |
| Haller, H | 1 |
| Riecken, EO | 3 |
| Wiedenmann, B | 4 |
| Anhert-Hilger, G | 1 |
| Stadtbäumer, A | 1 |
| Strübing, C | 1 |
| Scherübl, H | 2 |
| Schultz, G | 1 |
| John, M | 1 |
| Kruhøffer, M | 1 |
| Adermann, K | 1 |
| Ankorina-Stark, I | 1 |
| Schlatter, E | 1 |
| Forssmann, WG | 1 |
| Kuhn, M | 1 |
| Glassmeier, G | 1 |
| Höpfner, M | 1 |
| Buhr, H | 1 |
| Lemmer, K | 1 |
| Stein, H | 1 |
| Quabbe, HJ | 1 |
| Rancso, C | 1 |
| Taniguchi, H | 1 |
| Okada, Y | 1 |
| Shimada, C | 1 |
| Baba, S | 1 |
| Kusunoki, M | 1 |
| Yamamura, T | 1 |
| Ichii, S | 1 |
| Fujita, S | 1 |
| Nakai, T | 1 |
| Utsunomiya, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multicentre 3 Year Longitudinal Prospective Study to Identify Novel Endpoints and Compare These With Forced Expiratory Volume in 1 Second (FEV1) for Their Ability to Measure and Predict COPD Severity and Its Progression Over Time[NCT00292552] | 2,747 participants (Actual) | Observational | 2005-12-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for gamma-aminobutyric acid and Pancreatic Neoplasms
| Article | Year |
|---|---|
GABA (γ-aminobutyric acid), a non-protein amino acid counters the β-adrenergic cascade-activated oncogenic signaling in pancreatic cancer: a review of experimental evidence.
Topics: Adenylyl Cyclases; Animals; Cell Line, Tumor; gamma-Aminobutyric Acid; Humans; Pancreatic Neoplasms; | 2011 |
2 trials available for gamma-aminobutyric acid and Pancreatic Neoplasms
| Article | Year |
|---|---|
Targeted metabolomics identifies perturbations in amino acid metabolism that sub-classify patients with COPD.
Topics: Aged; Amino Acids; Biomarkers; Body Mass Index; Cachexia; Disease Progression; Female; gamma-Aminobu | 2012 |
The effects of sodium valproate on plasma somatostatin and insulin in humans.
Topics: Adult; Aged; Aged, 80 and over; Blood Glucose; C-Peptide; Female; gamma-Aminobutyric Acid; Humans; I | 1988 |
23 other studies available for gamma-aminobutyric acid and Pancreatic Neoplasms
| Article | Year |
|---|---|
GABRP regulates chemokine signalling, macrophage recruitment and tumour progression in pancreatic cancer through tuning KCNN4-mediated Ca
Topics: Adenocarcinoma; Animals; Chemokines; Disease Models, Animal; gamma-Aminobutyric Acid; Humans; Interm | 2019 |
Inhibition of EP2/EP4 prostanoid receptor-mediated signaling suppresses IGF-1-induced proliferation of pancreatic cancer BxPC-3 cells via upregulating γ-glutamyl cyclotransferase expression.
Topics: Cell Line, Tumor; Cell Proliferation; gamma-Aminobutyric Acid; gamma-Glutamylcyclotransferase; Human | 2019 |
Nicotine induces self-renewal of pancreatic cancer stem cells via neurotransmitter-driven activation of sonic hedgehog signalling.
Topics: Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Cell Self Renewal; Cell Separati | 2016 |
Nicotine stimulates pancreatic cancer xenografts by systemic increase in stress neurotransmitters and suppression of the inhibitory neurotransmitter gamma-aminobutyric acid.
Topics: Animals; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cyclic AMP; Epinephrine; Extracellular Sign | 2009 |
Nicotinic receptor-associated modulation of stimulatory and inhibitory neurotransmitters in NNK-induced adenocarcinoma of the lungs and pancreas.
Topics: Adenocarcinoma; Animals; Blotting, Western; Carcinoma, Pancreatic Ductal; Cricetinae; Cyclic AMP; El | 2009 |
Oxaliplatin-induced hyperexcitability syndrome in a patient with pancreatic cancer.
Topics: Adult; Anticonvulsants; Antineoplastic Agents; Female; gamma-Aminobutyric Acid; Humans; Isaacs Syndr | 2009 |
Diabetes mellitus decreases the expression of calcitonin-gene related peptide, gamma-amino butyric acid and glutamic acid decarboxylase in human pancreatic islet cells.
Topics: Calcitonin Gene-Related Peptide; Diabetes Mellitus, Type 2; Fluorescent Antibody Technique; gamma-Am | 2009 |
Regulation of pancreatic cancer by neuropsychological stress responses: a novel target for intervention.
Topics: Animals; Cell Line, Tumor; Cyclic AMP; Disease Progression; Epinephrine; gamma-Aminobutyric Acid; Hu | 2012 |
Effects of chronic nicotine on the autocrine regulation of pancreatic cancer cells and pancreatic duct epithelial cells by stimulatory and inhibitory neurotransmitters.
Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Epithelial Cells; gamma-Aminobutyric Acid; Glut | 2012 |
Celecoxib and GABA cooperatively prevent the progression of pancreatic cancer in vitro and in xenograft models of stress-free and stress-exposed mice.
Topics: Animals; Arachidonate 5-Lipoxygenase; Celecoxib; Cell Movement; Cell Proliferation; Cyclic AMP; Cycl | 2012 |
Gamma-amino butyric acid (GABA) prevents the induction of nicotinic receptor-regulated signaling by chronic ethanol in pancreatic cancer cells and normal duct epithelia.
Topics: Carcinoma, Pancreatic Ductal; Cell Movement; Cell Proliferation; Cells, Cultured; Dose-Response Rela | 2013 |
Gabapentin for coeliac plexus pain.
Topics: Acetates; Aged; Amines; Analgesics; Celiac Plexus; Cyclohexanecarboxylic Acids; Female; Gabapentin; | 2002 |
Hiccup in patients with advanced cancer successfully treated with gabapentin: report of three cases.
Topics: Acetates; Adult; Amines; Anticonvulsants; Brain Neoplasms; Carcinoma, Small Cell; Colonic Neoplasms; | 2003 |
Successful amelioration of oxaliplatin-induced hyperexcitability syndrome with the antiepileptic pregabalin in a patient with pancreatic cancer.
Topics: Adenocarcinoma; Adult; Anticonvulsants; Antimetabolites, Antineoplastic; Antineoplastic Agents; Calc | 2008 |
Gamma-aminobutyric acid (GABA) stimulates pancreatic cancer growth through overexpressing GABAA receptor pi subunit.
Topics: Calcium; Carcinoma, Pancreatic Ductal; Cell Growth Processes; Cell Line, Tumor; GABA Agents; gamma-A | 2007 |
GABA B receptor is a novel drug target for pancreatic cancer.
Topics: Adrenergic beta-Agonists; Baclofen; Blotting, Western; Bromodeoxyuridine; Cell Line; Cell Line, Tumo | 2008 |
Pancreatic acinar cell neoplasia in male Wistar rats following 2 years of gabapentin exposure.
Topics: Acetates; Adenoma; Amines; Animals; Anticonvulsants; Carcinoma, Acinar Cell; Cyclohexanecarboxylic A | 1995 |
Absence of Ki-ras mutations in exocrine pancreatic tumors from male rats chronically exposed to gabapentin.
Topics: Acetates; Adenocarcinoma; Adenoma; Amines; Animals; Base Sequence; Codon; Cyclohexanecarboxylic Acid | 1995 |
Rat pancreatic AR42J cells. Amphicrine cells as an in vitro model to study peptide hormone receptor regulation.
Topics: Animals; Calcium; Cell Line; Fluorescent Antibody Technique; gamma-Aminobutyric Acid; Gene Expressio | 1994 |
gamma-Aminobutyric acid secretion from pancreatic neuroendocrine cells.
Topics: Adult; Calcium Channels; gamma-Aminobutyric Acid; Humans; Membrane Proteins; Nerve Tissue Proteins; | 1996 |
Guanylin stimulates regulated secretion from human neuroendocrine pancreatic cells.
Topics: Bacterial Toxins; Calcium; Chromogranin A; Chromogranins; Cyclic GMP; Enterotoxins; Escherichia coli | 1998 |
Expression of functional GABAA receptors in isolated human insulinoma cells.
Topics: Cadmium Chloride; Calcium Channel Blockers; Calcium Channels; Female; gamma-Aminobutyric Acid; Human | 1998 |
GABA in pancreatic islets.
Topics: Adenoma, Islet Cell; Aminobutyrates; Animals; Central Nervous System; gamma-Aminobutyric Acid; Gluta | 1977 |