gamma-aminobutyric acid has been researched along with Osteoarthritis, Knee in 5 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
Osteoarthritis, Knee: Noninflammatory degenerative disease of the knee joint consisting of three large categories: conditions that block normal synchronous movement, conditions that produce abnormal pathways of motion, and conditions that cause stress concentration resulting in changes to articular cartilage. (Crenshaw, Campbell's Operative Orthopaedics, 8th ed, p2019)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We sought to compare a group (Group L) (n=21) of patients that underwent total knee arthroplasty and received a single preoperative dose of pregabalin combined with a COX-2 inhibitor with a control group (Group C) (n=20) that only received a COX-2 inhibitor in terms of (1) acute postoperative pain intensity, (2) analgesic consumption, and (3) functional recovery." | 2.80 | The effect of a single dose of preemptive pregabalin administered with COX-2 inhibitor: a trial in total knee arthroplasty. ( Choi, CH; Chung, KS; Lee, JK, 2015) |
| "Outcome measures were postsurgical pain at rest and during walking, consumption of opioids for pain rescue, knee swelling and knee range of motion, and complications." | 1.46 | Methylprednisolone reduces pain and decreases knee swelling in the first 24 h after fast-track unicompartmental knee arthroplasty. ( Hansen, TB; Munk, S; Rytter, S; Stilling, M, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ohtori, S | 1 |
| Inoue, G | 1 |
| Orita, S | 1 |
| Takaso, M | 1 |
| Eguchi, Y | 1 |
| Ochiai, N | 1 |
| Kishida, S | 1 |
| Kuniyoshi, K | 1 |
| Aoki, Y | 1 |
| Ishikawa, T | 1 |
| Miyagi, M | 1 |
| Kamoda, H | 1 |
| Suzkuki, M | 1 |
| Nakamura, J | 1 |
| Kubota, G | 1 |
| Sakuma, Y | 1 |
| Oikawa, Y | 1 |
| Toyone, T | 1 |
| Inage, K | 1 |
| Sainoh, T | 1 |
| Yamauchi, K | 1 |
| Takahashi, K | 1 |
| Lee, JK | 1 |
| Chung, KS | 1 |
| Choi, CH | 1 |
| Rytter, S | 1 |
| Stilling, M | 1 |
| Munk, S | 1 |
| Hansen, TB | 1 |
| Reckziegel, D | 1 |
| Raschke, F | 1 |
| Cottam, WJ | 1 |
| Auer, DP | 1 |
| Bove, SE | 1 |
| Laemont, KD | 1 |
| Brooker, RM | 1 |
| Osborn, MN | 1 |
| Sanchez, BM | 1 |
| Guzman, RE | 1 |
| Hook, KE | 1 |
| Juneau, PL | 1 |
| Connor, JR | 1 |
| Kilgore, KS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Impact of Pre-emptive Large Doses of Methylprednisolone Combined With Gabapentin on Pain Treatment and Convalescence After Total Knee Arthroplasty in Elderly: A Double-blind Randomized Study[NCT04653415] | Phase 4 | 160 participants (Actual) | Interventional | 2019-06-01 | Completed | ||
| The Effect of Preoperative Steroids Injection on Pain and Oedema After Total Knee Arthroplasty . A Double -Blinded Randomized Controlled Study.[NCT04084912] | Phase 3 | 86 participants (Anticipated) | Interventional | 2020-01-01 | Not yet recruiting | ||
| Efficacy of Steroids on Functional Outcomes After Musculoskeletal Injuries of the Hand[NCT05003596] | Phase 2/Phase 3 | 60 participants (Anticipated) | Interventional | 2021-09-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for gamma-aminobutyric acid and Osteoarthritis, Knee
| Article | Year |
|---|---|
Efficacy of combination of meloxicam and pregabalin for pain in knee osteoarthritis.
Topics: Aged; Aged, 80 and over; Drug Therapy, Combination; Female; gamma-Aminobutyric Acid; Humans; Male; M | 2013 |
The effect of a single dose of preemptive pregabalin administered with COX-2 inhibitor: a trial in total knee arthroplasty.
Topics: Aged; Analgesics; Arthroplasty, Replacement, Knee; Cyclooxygenase 2 Inhibitors; gamma-Aminobutyric A | 2015 |
3 other studies available for gamma-aminobutyric acid and Osteoarthritis, Knee
| Article | Year |
|---|---|
Methylprednisolone reduces pain and decreases knee swelling in the first 24 h after fast-track unicompartmental knee arthroplasty.
Topics: Acetaminophen; Aged; Aged, 80 and over; Amines; Analgesics; Anti-Inflammatory Agents; Arthroplasty, | 2017 |
Methylprednisolone reduces pain and decreases knee swelling in the first 24 h after fast-track unicompartmental knee arthroplasty.
Topics: Acetaminophen; Aged; Aged, 80 and over; Amines; Analgesics; Anti-Inflammatory Agents; Arthroplasty, | 2017 |
Methylprednisolone reduces pain and decreases knee swelling in the first 24 h after fast-track unicompartmental knee arthroplasty.
Topics: Acetaminophen; Aged; Aged, 80 and over; Amines; Analgesics; Anti-Inflammatory Agents; Arthroplasty, | 2017 |
Methylprednisolone reduces pain and decreases knee swelling in the first 24 h after fast-track unicompartmental knee arthroplasty.
Topics: Acetaminophen; Aged; Aged, 80 and over; Amines; Analgesics; Anti-Inflammatory Agents; Arthroplasty, | 2017 |
Cingulate GABA levels inversely correlate with the intensity of ongoing chronic knee osteoarthritis pain.
Topics: Aged; Demography; Female; gamma-Aminobutyric Acid; Gyrus Cinguli; Humans; Magnetic Resonance Imaging | 2016 |
Surgically induced osteoarthritis in the rat results in the development of both osteoarthritis-like joint pain and secondary hyperalgesia.
Topics: Amines; Analgesics; Animals; Arthralgia; Cyclohexanecarboxylic Acids; Cyclooxygenase 2 Inhibitors; D | 2006 |