gamma-aminobutyric acid has been researched along with Obesity in 53 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this study, gamma-aminobutyric acid (GABA) enriched rice bran (ERB) was supplemented to obese rats to investigate the attenuation of metabolic syndromes induced by high-fat diet." | 7.88 | Gamma-aminobutyric Acid Enriched Rice Bran Diet Attenuates Insulin Resistance and Balances Energy Expenditure via Modification of Gut Microbiota and Short-Chain Fatty Acids. ( Blanchard, C; Lam, SM; Shang, W; Shui, G; Si, X; Strappe, P; Zhou, Z, 2018) |
| " Our metabolomic analyses reveal that gamma-aminobutyric acid (GABA) levels are increased in the interscapular BAT of mice with dietary obesity." | 7.88 | Gamma-Aminobutyric Acid Signaling in Brown Adipose Tissue Promotes Systemic Metabolic Derangement in Obesity. ( Hayashi, Y; Hinoi, E; Ikegami, R; Jespersen, NZ; Katsuumi, G; Li, J; Minamino, T; Minokoshi, Y; Nielsen, S; Okamoto, S; Sato, T; Scheele, C; Shimizu, I; Soga, T; Suda, M; Wakasugi, T; Yoshida, Y, 2018) |
| "Leptin acts in the brain to prevent obesity." | 7.77 | Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons. ( Choi, B; Chua, S; Lowell, BB; Vong, L; Yang, Z; Ye, C, 2011) |
| "Glycogen levels were also lower in this region." | 5.36 | Obesity and type 2 diabetes in rats are associated with altered brain glycogen and amino-acid homeostasis. ( Benie, AJ; Bouman, SD; Schousboe, A; Sickmann, HM; Waagepetersen, HS, 2010) |
| "Obesity and type 2 diabetes have reached epidemic proportions; however, scarce information about how these metabolic syndromes influence brain energy and neurotransmitter homeostasis exist." | 5.36 | Obesity and type 2 diabetes in rats are associated with altered brain glycogen and amino-acid homeostasis. ( Benie, AJ; Bouman, SD; Schousboe, A; Sickmann, HM; Waagepetersen, HS, 2010) |
| "In this study, gamma-aminobutyric acid (GABA) enriched rice bran (ERB) was supplemented to obese rats to investigate the attenuation of metabolic syndromes induced by high-fat diet." | 3.88 | Gamma-aminobutyric Acid Enriched Rice Bran Diet Attenuates Insulin Resistance and Balances Energy Expenditure via Modification of Gut Microbiota and Short-Chain Fatty Acids. ( Blanchard, C; Lam, SM; Shang, W; Shui, G; Si, X; Strappe, P; Zhou, Z, 2018) |
| " We hypothesized that the body weight setpoint of the DIO-D phenotype resides in the hypothalamic paraventricular nucleus (PVN), where anorexigenic melanocortins, including melanotan II (MTII), increase presynaptic GABA release, and the orexigenic neuropeptide Y (NPY) inhibits it." | 3.81 | Defense of Elevated Body Weight Setpoint in Diet-Induced Obese Rats on Low Energy Diet Is Mediated by Loss of Melanocortin Sensitivity in the Paraventricular Hypothalamic Nucleus. ( Baracos, VE; Chee, MJ; Colmers, WF; Doslikova, B; Luchtman, DW; Marks, DL, 2015) |
| "Leptin acts in the brain to prevent obesity." | 3.77 | Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons. ( Choi, B; Chua, S; Lowell, BB; Vong, L; Yang, Z; Ye, C, 2011) |
| "Whole brain concentrations of 3-hydroxybutyrate, glutamate and gamma-aminobutyric acid (GABA) have been measured in two strains of rats with differing susceptibility to obesity." | 3.67 | Brain 3-hydroxybutyrate, glutamate, and GABA in a rat model of dietary obesity. ( Bray, GA; Fisler, JS; Shimizu, H, 1989) |
| "We hypothesized that an antineuropathic pain drug like pregabalin could be helpful to optimize postoperative analgesia by reducing the requirement for opioids and their associated side effects." | 2.75 | Analgesic effects of a single preoperative dose of pregabalin after laparoscopic sleeve gastrectomy. ( Cabrera Schulmeyer, MC; de la Maza, J; Farias, C; Ovalle, C; Vives, I, 2010) |
| "Obesity is one of the leading health concerns in the United States." | 1.91 | Differential regulation of nucleus accumbens glutamate and GABA in obesity-prone and obesity-resistant rats. ( Addis, VM; Boulnemour, KM; Ferrario, CR; Kennedy, RT; Micheli, DA; Nesbitt, KM; Sandoval, DA; Smith, KB; Vollbrecht, PJ, 2023) |
| "Sarcopenic obesity is characterized by concurrent obesity and muscle wasting (sarcopenia) and is common in the elderly." | 1.91 | GABA Prevents Age-Related Sarcopenic Obesity in Mice with High-Fat-Diet-Induced Obesity. ( Jin, H; Lee, BY; Oh, HJ, 2023) |
| "Sarcopenic obesity has steadily increased as the aging population has grown and is an increasing public health burden." | 1.91 | GABA Prevents Age-Related Sarcopenic Obesity in Mice with High-Fat-Diet-Induced Obesity. ( Jin, H; Lee, BY; Oh, HJ, 2023) |
| "Obesity has become a worldwide health challenge and commonly results from the intake of more calories than the body requires." | 1.91 | Modulation of GABA release by 5-HT ( Heisler, LK; Najm Al-Halboosi, DA; Savchenko, O; Sylantyev, S, 2023) |
| " GBP has a favorable adverse effect profile in therapeutic dosing with the most common reported effects being dizziness, fatigue, drowsiness, weight gain, and peripheral edema." | 1.42 | An acute gabapentin fatality: a case report with postmortem concentrations. ( Cantrell, FL; Gary, RD; McIntyre, IM; Mena, O, 2015) |
| "Glycogen levels were also lower in this region." | 1.36 | Obesity and type 2 diabetes in rats are associated with altered brain glycogen and amino-acid homeostasis. ( Benie, AJ; Bouman, SD; Schousboe, A; Sickmann, HM; Waagepetersen, HS, 2010) |
| "Obesity and type 2 diabetes have reached epidemic proportions; however, scarce information about how these metabolic syndromes influence brain energy and neurotransmitter homeostasis exist." | 1.36 | Obesity and type 2 diabetes in rats are associated with altered brain glycogen and amino-acid homeostasis. ( Benie, AJ; Bouman, SD; Schousboe, A; Sickmann, HM; Waagepetersen, HS, 2010) |
| "Obesity is often associated with a reduced ventilatory response and a decreased maximal exercise capacity." | 1.31 | GABAergic modulation of ventilation and peak oxygen consumption in obese Zucker rats. ( Farkas, GA; Lee, SD; Nakano, H, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (13.21) | 18.7374 |
| 1990's | 3 (5.66) | 18.2507 |
| 2000's | 7 (13.21) | 29.6817 |
| 2010's | 23 (43.40) | 24.3611 |
| 2020's | 13 (24.53) | 2.80 |
| Authors | Studies |
|---|---|
| Yong, Y | 1 |
| Cakir, I | 1 |
| Lining Pan, P | 1 |
| Biddinger, JE | 1 |
| Bluett, RJ | 1 |
| Mackie, K | 2 |
| Bingham, N | 1 |
| Patel, S | 1 |
| Ghamari-Langroudi, M | 1 |
| Manigandan, S | 1 |
| Yun, JW | 1 |
| Lee, HY | 1 |
| Lee, GH | 1 |
| Hoang, TH | 1 |
| Kim, YM | 1 |
| Jang, GH | 1 |
| Seok, CH | 1 |
| Gwak, YG | 1 |
| Lim, J | 2 |
| Kim, J | 1 |
| Chae, HJ | 1 |
| Vollbrecht, PJ | 1 |
| Nesbitt, KM | 1 |
| Addis, VM | 1 |
| Boulnemour, KM | 1 |
| Micheli, DA | 1 |
| Smith, KB | 1 |
| Sandoval, DA | 1 |
| Kennedy, RT | 1 |
| Ferrario, CR | 1 |
| Wang, FZ | 1 |
| Qian, P | 1 |
| Liu, MY | 1 |
| Ding, L | 1 |
| Wang, HY | 1 |
| Wang, Q | 1 |
| Ding, ZY | 1 |
| Jin, FY | 1 |
| Li, RG | 1 |
| Zhou, YB | 1 |
| Caramelo, B | 1 |
| Monteiro-Alfredo, T | 1 |
| Martins, J | 1 |
| Sereno, J | 1 |
| Castelhano, J | 1 |
| Manadas, B | 1 |
| Castelo-Branco, M | 1 |
| Matafome, P | 1 |
| González-García, I | 1 |
| García-Cáceres, C | 1 |
| Sa, M | 1 |
| Yoo, ES | 1 |
| Koh, W | 1 |
| Park, MG | 1 |
| Jang, HJ | 1 |
| Yang, YR | 1 |
| Bhalla, M | 1 |
| Lee, JH | 1 |
| Won, W | 1 |
| Kwon, J | 1 |
| Kwon, JH | 1 |
| Seong, Y | 1 |
| Kim, B | 1 |
| An, H | 1 |
| Lee, SE | 1 |
| Park, KD | 1 |
| Suh, PG | 1 |
| Sohn, JW | 1 |
| Lee, CJ | 1 |
| Jin, H | 1 |
| Oh, HJ | 1 |
| Lee, BY | 1 |
| Najm Al-Halboosi, DA | 1 |
| Savchenko, O | 1 |
| Heisler, LK | 1 |
| Sylantyev, S | 1 |
| Samarra, I | 1 |
| Ramos-Molina, B | 1 |
| Queipo-Ortuño, MI | 1 |
| Tinahones, FJ | 1 |
| Arola, L | 1 |
| Delpino-Rius, A | 1 |
| Herrero, P | 1 |
| Canela, N | 1 |
| Xia, G | 1 |
| Han, Y | 1 |
| Meng, F | 1 |
| He, Y | 1 |
| Srisai, D | 1 |
| Farias, M | 1 |
| Dang, M | 1 |
| Palmiter, RD | 1 |
| Xu, Y | 2 |
| Wu, Q | 1 |
| Geisler, CE | 2 |
| Ghimire, S | 2 |
| Bruggink, SM | 2 |
| Miller, KE | 2 |
| Weninger, SN | 1 |
| Kronenfeld, JM | 1 |
| Yoshino, J | 2 |
| Klein, S | 2 |
| Duca, FA | 1 |
| Renquist, BJ | 2 |
| Hepler, C | 1 |
| Kentch, KP | 1 |
| Higgins, MR | 1 |
| Banek, CT | 1 |
| Holmberg, E | 1 |
| Sjöstedt, J | 1 |
| Malinina, E | 1 |
| Johansson, M | 1 |
| Turkmen, S | 1 |
| Ragagnin, G | 1 |
| Lundqvist, A | 1 |
| Löfgren, M | 1 |
| Jaukkuri, L | 1 |
| Bixo, M | 1 |
| Bäckström, T | 1 |
| Shalev, D | 1 |
| Arbuckle, MR | 1 |
| Shen, Z | 1 |
| Weng, C | 1 |
| Zhang, Z | 1 |
| Wang, X | 1 |
| Yang, K | 1 |
| Si, X | 1 |
| Shang, W | 1 |
| Zhou, Z | 1 |
| Shui, G | 1 |
| Lam, SM | 1 |
| Blanchard, C | 1 |
| Strappe, P | 1 |
| Ikegami, R | 1 |
| Shimizu, I | 1 |
| Sato, T | 1 |
| Yoshida, Y | 1 |
| Hayashi, Y | 1 |
| Suda, M | 1 |
| Katsuumi, G | 1 |
| Li, J | 1 |
| Wakasugi, T | 1 |
| Minokoshi, Y | 1 |
| Okamoto, S | 1 |
| Hinoi, E | 1 |
| Nielsen, S | 1 |
| Jespersen, NZ | 1 |
| Scheele, C | 1 |
| Soga, T | 1 |
| Minamino, T | 1 |
| Untereiner, A | 1 |
| Abdo, S | 1 |
| Bhattacharjee, A | 1 |
| Gohil, H | 1 |
| Pourasgari, F | 1 |
| Ibeh, N | 1 |
| Lai, M | 1 |
| Batchuluun, B | 1 |
| Wong, A | 1 |
| Khuu, N | 1 |
| Liu, Y | 1 |
| Al Rijjal, D | 1 |
| Winegarden, N | 1 |
| Virtanen, C | 1 |
| Orser, BA | 1 |
| Cabrera, O | 1 |
| Varga, G | 1 |
| Rocheleau, J | 1 |
| Dai, FF | 1 |
| Wheeler, MB | 1 |
| Hwang, I | 1 |
| Jo, K | 1 |
| Shin, KC | 1 |
| Kim, JI | 1 |
| Ji, Y | 1 |
| Park, YJ | 1 |
| Park, J | 1 |
| Jeon, YG | 1 |
| Ka, S | 1 |
| Suk, S | 1 |
| Noh, HL | 1 |
| Choe, SS | 1 |
| Alfadda, AA | 1 |
| Kim, JK | 1 |
| Kim, S | 1 |
| Kim, JB | 1 |
| Pintana, H | 1 |
| Lietzau, G | 1 |
| Augestad, IL | 1 |
| Chiazza, F | 1 |
| Nyström, T | 1 |
| Patrone, C | 1 |
| Darsalia, V | 1 |
| Jennings, JH | 1 |
| Rizzi, G | 1 |
| Stamatakis, AM | 1 |
| Ung, RL | 1 |
| Stuber, GD | 1 |
| Chukwu, J | 1 |
| Delanty, N | 1 |
| Webb, D | 1 |
| Cavalleri, GL | 1 |
| Abreu, AR | 1 |
| de Abreu, AR | 1 |
| Santos, LT | 1 |
| de Souza, AA | 1 |
| da Silva, LG | 1 |
| Chianca, DA | 1 |
| de Menezes, RC | 1 |
| Trivedi, BP | 1 |
| Zhang, H | 1 |
| Pu, Y | 1 |
| Chen, J | 1 |
| Tong, W | 1 |
| Cui, Y | 1 |
| Sun, F | 1 |
| Zheng, Z | 1 |
| Li, Q | 1 |
| Yang, T | 1 |
| Meng, C | 1 |
| Lu, Z | 1 |
| Li, L | 1 |
| Yan, Z | 1 |
| Liu, D | 1 |
| Zhu, Z | 1 |
| Cantrell, FL | 1 |
| Mena, O | 1 |
| Gary, RD | 1 |
| McIntyre, IM | 1 |
| Luchtman, DW | 1 |
| Chee, MJ | 1 |
| Doslikova, B | 1 |
| Marks, DL | 1 |
| Baracos, VE | 1 |
| Colmers, WF | 1 |
| Sandoval-Salazar, C | 1 |
| Ramírez-Emiliano, J | 1 |
| Trejo-Bahena, A | 1 |
| Oviedo-Solís, CI | 1 |
| Solís-Ortiz, MS | 1 |
| Cabrera Schulmeyer, MC | 1 |
| de la Maza, J | 1 |
| Ovalle, C | 1 |
| Farias, C | 1 |
| Vives, I | 1 |
| Sickmann, HM | 1 |
| Waagepetersen, HS | 1 |
| Schousboe, A | 1 |
| Benie, AJ | 1 |
| Bouman, SD | 1 |
| Massa, F | 1 |
| Mancini, G | 1 |
| Schmidt, H | 1 |
| Steindel, F | 1 |
| Angioni, C | 1 |
| Oliet, SH | 1 |
| Geisslinger, G | 1 |
| Lutz, B | 1 |
| Huber, DA | 1 |
| Schreihofer, AM | 1 |
| Vong, L | 1 |
| Ye, C | 1 |
| Yang, Z | 1 |
| Choi, B | 1 |
| Chua, S | 1 |
| Lowell, BB | 1 |
| O'Brien, WG | 1 |
| Lee, CC | 1 |
| Myers, MG | 1 |
| Tong, Q | 1 |
| van den Pol, AN | 1 |
| Boutin, P | 1 |
| Dina, C | 1 |
| Vasseur, F | 1 |
| Dubois, S | 1 |
| Corset, L | 1 |
| Séron, K | 1 |
| Bekris, L | 1 |
| Cabellon, J | 1 |
| Neve, B | 1 |
| Vasseur-Delannoy, V | 1 |
| Chikri, M | 1 |
| Charles, MA | 1 |
| Clement, K | 1 |
| Lernmark, A | 1 |
| Froguel, P | 1 |
| Bäckberg, M | 1 |
| Meister, B | 1 |
| Kleiner, KD | 1 |
| Gold, MS | 1 |
| Frost-Pineda, K | 1 |
| Lenz-Brunsman, B | 1 |
| Perri, MG | 1 |
| Jacobs, WS | 1 |
| Orosco, M | 2 |
| Bremond, J | 1 |
| Jacquot, C | 2 |
| Cohen, Y | 2 |
| Wepierre, J | 1 |
| Tews, JK | 1 |
| Specter, SE | 1 |
| Horwitz, BA | 1 |
| Beverly, JL | 2 |
| Lee, SD | 1 |
| Nakano, H | 1 |
| Farkas, GA | 1 |
| Song, Z | 1 |
| Levin, BE | 1 |
| McArdle, JJ | 1 |
| Bakhos, N | 1 |
| Routh, VH | 1 |
| Coscina, DV | 1 |
| Castonguay, TW | 1 |
| Stern, JS | 1 |
| Tsujii, S | 1 |
| Bray, GA | 2 |
| Fisler, JS | 1 |
| Shimizu, H | 1 |
| Martin, RJ | 2 |
| Squadrito, F | 1 |
| Sturniolo, R | 1 |
| Arcadi, F | 1 |
| Arcoraci, V | 1 |
| Caputi, AP | 1 |
| Jeanrenaud, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Role of the Gut Microbiome as Determinant of Depression in Multiple Sclerosis Subjects[NCT05808101] | 120 participants (Anticipated) | Observational | 2022-01-27 | Recruiting | |||
| Analgesic Effect of Pregabalin in Patients Undergoing Total Abdominal Hysterectomy[NCT01466101] | 0 participants (Actual) | Interventional | 2011-01-31 | Withdrawn (stopped due to PI left the institution. No subjects screened or enrolled.) | |||
| Preoperative Use of Pregabalin and Analgesia Levels After Laparoscopic Cholecystectomy[NCT01321801] | 50 participants (Actual) | Interventional | 2009-11-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for gamma-aminobutyric acid and Obesity
| Article | Year |
|---|---|
Allopregnanolone involvement in feeding regulation, overeating and obesity.
Topics: Animals; Female; gamma-Aminobutyric Acid; Humans; Hyperphagia; Obesity; Polycystic Ovary Syndrome; P | 2018 |
Weight change, genetics and antiepileptic drugs.
Topics: Animals; Anticonvulsants; Epilepsy; gamma-Aminobutyric Acid; Genetic Predisposition to Disease; Huma | 2014 |
Weighing the role of hypothalamic feeding neurotransmitters.
Topics: Animals; Feeding Behavior; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Hypothalamus; Neurotransm | 2003 |
2 trials available for gamma-aminobutyric acid and Obesity
| Article | Year |
|---|---|
A critical role of hepatic GABA in the metabolic dysfunction and hyperphagia of obesity.
Topics: 4-Aminobutyrate Transaminase; Animals; Biomarkers; Diet, High-Fat; Energy Metabolism; Feeding Behavi | 2021 |
Analgesic effects of a single preoperative dose of pregabalin after laparoscopic sleeve gastrectomy.
Topics: Adult; Aged; Analgesia; Analgesics; Analgesics, Opioid; Antiemetics; Double-Blind Method; Female; ga | 2010 |
Analgesic effects of a single preoperative dose of pregabalin after laparoscopic sleeve gastrectomy.
Topics: Adult; Aged; Analgesia; Analgesics; Analgesics, Opioid; Antiemetics; Double-Blind Method; Female; ga | 2010 |
Analgesic effects of a single preoperative dose of pregabalin after laparoscopic sleeve gastrectomy.
Topics: Adult; Aged; Analgesia; Analgesics; Analgesics, Opioid; Antiemetics; Double-Blind Method; Female; ga | 2010 |
Analgesic effects of a single preoperative dose of pregabalin after laparoscopic sleeve gastrectomy.
Topics: Adult; Aged; Analgesia; Analgesics; Analgesics, Opioid; Antiemetics; Double-Blind Method; Female; ga | 2010 |
48 other studies available for gamma-aminobutyric acid and Obesity
| Article | Year |
|---|---|
Endogenous cannabinoids are required for MC4R-mediated control of energy homeostasis.
Topics: Animals; Arachidonic Acids; Body Weight; Cannabinoids; Endocannabinoids; Energy Metabolism; Fasting; | 2021 |
Loss of cytoplasmic FMR1-interacting protein 2 (CYFIP2) induces browning in 3T3-L1 adipocytes via repression of GABA-BR and activation of mTORC1.
Topics: 3T3-L1 Cells; Adaptor Proteins, Signal Transducing; Adipocytes, Brown; Adipocytes, White; Animals; g | 2022 |
GABA and Fermented
Topics: Animals; Curcuma; Diet, High-Fat; Endoribonucleases; gamma-Aminobutyric Acid; Mice; Mice, Inbred C57 | 2022 |
Differential regulation of nucleus accumbens glutamate and GABA in obesity-prone and obesity-resistant rats.
Topics: Animals; gamma-Aminobutyric Acid; Glucose; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Human | 2023 |
Adrenomedullin in paraventricular nucleus attenuates adipose afferent reflex and sympathoexcitation via receptors mediated nitric oxide-gamma-aminobutyric acid A type receptor pathway in rats with obesity-related hypertension.
Topics: Adrenomedullin; Animals; Bicuculline; Blood Pressure; gamma-Aminobutyric Acid; Hypertension; Nitric | 2023 |
Functional imaging and neurochemistry identify in vivo neuroprotection mechanisms counteracting excitotoxicity and neurovascular changes in the hippocampus and visual cortex of obese and type 2 diabetic animal models.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; gamma-Aminobutyric Acid; Glutam | 2023 |
Astrocytic GABA in LHA is an obesity 'thermostat'.
Topics: gamma-Aminobutyric Acid; Obesity | 2023 |
Hypothalamic GABRA5-positive neurons control obesity via astrocytic GABA.
Topics: Animals; Astrocytes; Disease Models, Animal; gamma-Aminobutyric Acid; Male; Mice; Monoamine Oxidase; | 2023 |
GABA Prevents Age-Related Sarcopenic Obesity in Mice with High-Fat-Diet-Induced Obesity.
Topics: Animals; Diet, High-Fat; gamma-Aminobutyric Acid; Mice; Mice, Obese; Muscle, Skeletal; Obesity; Sarc | 2023 |
Modulation of GABA release by 5-HT
Topics: Agouti-Related Protein; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arcuate N | 2023 |
Gender-Related Differences on Polyamine Metabolome in Liquid Biopsies by a Simple and Sensitive Two-Step Liquid-Liquid Extraction and LC-MS/MS.
Topics: Acetylation; Cadaverine; Chromatography, Liquid; Dansyl Compounds; Diamines; Female; gamma-Aminobuty | 2019 |
Reciprocal control of obesity and anxiety-depressive disorder via a GABA and serotonin neural circuit.
Topics: Agouti-Related Protein; Anxiety; Depression; Depressive Disorder; gamma-Aminobutyric Acid; Humans; O | 2021 |
Hepatocyte membrane potential regulates serum insulin and insulin sensitivity by altering hepatic GABA release.
Topics: Animals; Blood Glucose; Diet; Female; gamma-Aminobutyric Acid; Hepatocytes; Humans; Hyperinsulinism; | 2021 |
Metabolism and Memory: Obesity, Diabetes, and Dementia.
Topics: Dementia; gamma-Aminobutyric Acid; Humans; Islet Amyloid Polypeptide; Memory; Obesity | 2017 |
Renal sympathetic denervation lowers arterial pressure in canines with obesity-induced hypertension by regulating GAD65 and AT
Topics: Angiotensin II; Animals; Blood Pressure; Dogs; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hyp | 2018 |
Gamma-aminobutyric Acid Enriched Rice Bran Diet Attenuates Insulin Resistance and Balances Energy Expenditure via Modification of Gut Microbiota and Short-Chain Fatty Acids.
Topics: Adipose Tissue; Animals; Ceramides; Diet; Diet, High-Fat; DNA; Energy Metabolism; Fatty Acids, Volat | 2018 |
Gamma-Aminobutyric Acid Signaling in Brown Adipose Tissue Promotes Systemic Metabolic Derangement in Obesity.
Topics: Adipose Tissue, Brown; Adipose Tissue, White; Animals; Female; gamma-Aminobutyric Acid; Male; Metabo | 2018 |
GABA promotes β-cell proliferation, but does not overcome impaired glucose homeostasis associated with diet-induced obesity.
Topics: Animals; Cell Line; Cell Proliferation; Cells, Cultured; Diet, High-Fat; gamma-Aminobutyric Acid; Gl | 2019 |
GABA-stimulated adipose-derived stem cells suppress subcutaneous adipose inflammation in obesity.
Topics: Adipocytes; Adipose Tissue; Adiposity; Animals; Diet, High-Fat; Female; gamma-Aminobutyric Acid; Hum | 2019 |
Obesity-induced type 2 diabetes impairs neurological recovery after stroke in correlation with decreased neurogenesis and persistent atrophy of parvalbumin-positive interneurons.
Topics: Age Factors; Animals; Atrophy; Brain; Diabetes Mellitus, Type 2; Disease Models, Animal; gamma-Amino | 2019 |
The inhibitory circuit architecture of the lateral hypothalamus orchestrates feeding.
Topics: Adaptation, Physiological; Amygdala; Animals; Bacterial Proteins; Channelrhodopsins; Eating; Feeding | 2013 |
Blunted GABA-mediated inhibition within the dorsomedial hypothalamus potentiates the cardiovascular response to emotional stress in rats fed a high-fat diet.
Topics: Animals; Arterial Pressure; Bicuculline; Diet, High-Fat; Emotions; GABA-A Receptor Agonists; GABA-A | 2014 |
Neuroscience: Dissecting appetite.
Topics: Agouti-Related Protein; Animals; Anorexia; Appetite; Arcuate Nucleus of Hypothalamus; Calcitonin Gen | 2014 |
Gastrointestinal intervention ameliorates high blood pressure through antagonizing overdrive of the sympathetic nerve in hypertensive patients and rats.
Topics: Adult; Animals; Biomarkers; Blood Pressure; Cardiovascular System; Cold-Shock Response; Diabetes Mel | 2014 |
An acute gabapentin fatality: a case report with postmortem concentrations.
Topics: Amines; Analgesics; Cardiovascular Diseases; Chromatography, Liquid; Cyclohexanecarboxylic Acids; Fe | 2015 |
Defense of Elevated Body Weight Setpoint in Diet-Induced Obese Rats on Low Energy Diet Is Mediated by Loss of Melanocortin Sensitivity in the Paraventricular Hypothalamic Nucleus.
Topics: alpha-MSH; Animals; Arcuate Nucleus of Hypothalamus; Body Weight; Caloric Restriction; Diet; Dietary | 2015 |
A high-fat diet decreases GABA concentration in the frontal cortex and hippocampus of rats.
Topics: Animals; Blood Glucose; Body Weight; Diet, High-Fat; Feeding Behavior; Frontal Lobe; gamma-Aminobuty | 2016 |
Obesity and type 2 diabetes in rats are associated with altered brain glycogen and amino-acid homeostasis.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Blood Glucose; Brain; Diabetes Mellitus, Type 2; gamma | 2010 |
Alterations in the hippocampal endocannabinoid system in diet-induced obese mice.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Dietary Fats; Disease Models, Animal; E | 2010 |
Altered regulation of the rostral ventrolateral medulla in hypertensive obese Zucker rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Brain Stem; Excita | 2011 |
Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons.
Topics: Agouti-Related Protein; Animals; Brain; Disease Models, Animal; Excitatory Postsynaptic Potentials; | 2011 |
Role of GABA release from leptin receptor-expressing neurons in body weight regulation.
Topics: Animals; Body Weight; Eating; Energy Metabolism; gamma-Aminobutyric Acid; Leptin; Mice; Mice, Transg | 2012 |
GAD2 on chromosome 10p12 is a candidate gene for human obesity.
Topics: Adult; Aged; Alleles; Autoantibodies; Case-Control Studies; Catalysis; Cell Line; Chromosome Mapping | 2003 |
Abnormal cholinergic and GABAergic vascular innervation in the hypothalamic arcuate nucleus of obese tub/tub mice.
Topics: Acetylcholine; Adaptor Proteins, Signal Transducing; Animals; Arcuate Nucleus of Hypothalamus; Blood | 2004 |
Body mass index and alcohol use.
Topics: Adolescent; Adult; Alcoholism; Behavior, Addictive; Body Mass Index; Brain; Comorbidity; Female; gam | 2004 |
Fenfluramine and brain transmitters in the obese Zucker rat.
Topics: Animals; Body Weight; Brain Chemistry; Catecholamines; Dopamine; Feeding Behavior; Female; Fenfluram | 1984 |
GABA levels and synthesis index in different brain areas of two obese rat models.
Topics: Aminocaproates; Animals; Brain Chemistry; Female; gamma-Aminobutyric Acid; Hypothalamus, Middle; Obe | 1981 |
Dietary GABA decreases body weight of genetically obese mice.
Topics: 4-Aminobutyrate Transaminase; Animals; Body Weight; Diet; Eating; gamma-Aminobutyric Acid; Growth; M | 1981 |
Basal and glucoprivic-induced changes in extracellular GABA in the ventral hypothalamus of Zucker rats.
Topics: Animals; Deoxyglucose; Extracellular Space; gamma-Aminobutyric Acid; Glucose; Hypothalamic Area, Lat | 1996 |
Valproate and other anticonvulsants for psychiatric disorders.
Topics: Abnormalities, Drug-Induced; Acetates; Adult; Amines; Anti-Anxiety Agents; Anticonvulsants; Bipolar | 2000 |
GABAergic modulation of ventilation and peak oxygen consumption in obese Zucker rats.
Topics: Animals; Bicuculline; Carbon Dioxide; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hypercap | 2001 |
Convergence of pre- and postsynaptic influences on glucosensing neurons in the ventromedial hypothalamic nucleus.
Topics: Adenosine Triphosphate; Animals; Cell Count; Diabetes Mellitus, Type 2; Diet; gamma-Aminobutyric Aci | 2001 |
Effects of increasing brain GABA on the meal patterns of genetically obese vs. lean Zucker rats.
Topics: Animals; Body Weight; Brain Chemistry; Dose-Response Relationship, Drug; Eating; Ethanolamines; Fema | 1992 |
GABA-related feeding control in genetically obese rats.
Topics: Animals; Deoxyglucose; Feeding Behavior; Female; gamma-Aminobutyric Acid; Hypothalamic Area, Lateral | 1991 |
Brain 3-hydroxybutyrate, glutamate, and GABA in a rat model of dietary obesity.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Brain; Brain Chemistry; Corticosterone; Dietary Fats; | 1989 |
Increased GABA shunt activity in VMN of three hyperphagic rat models.
Topics: Animals; Diet, Reducing; Disease Models, Animal; Feeding Behavior; gamma-Aminobutyric Acid; Glucose; | 1989 |
Evidence that a GABAergic mechanism influences the development of obesity in obese Zucker rats.
Topics: Animals; beta-Endorphin; Body Weight; gamma-Aminobutyric Acid; Insulin; Obesity; Rats; Rats, Zucker; | 1988 |
Growth hormone in obesity and diabetes: inappropriate hypothalamic control of secretion.
Topics: Animals; Bicuculline; Blood Glucose; Diabetes Mellitus; gamma-Aminobutyric Acid; Growth Hormone; Hyp | 1985 |