Page last updated: 2024-10-16

gamma-aminobutyric acid and Nociceptive Pain

gamma-aminobutyric acid has been researched along with Nociceptive Pain in 12 studies

gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.

Nociceptive Pain: Dull or sharp aching pain caused by stimulated NOCICEPTORS due to tissue injury, inflammation or diseases. It can be divided into somatic or tissue pain and VISCERAL PAIN.

Research Excerpts

ExcerptRelevanceReference
"This study investigated whether the spinal or systemic treatment with the lipid resolution mediators resolvin D1 (RvD1), aspirin-triggered resolvin D1 (AT-RvD1) and resolvin D2 (RvD2) might interfere with behavioral and neurochemical changes in the mouse fibromyalgia-like model induced by reserpine."3.80Effects of D-series resolvins on behavioral and neurochemical changes in a fibromyalgia-like model in mice. ( Campos, MM; Klein, CP; Leite, CE; Maciel, IS; Souza, AH; Sperotto, ND, 2014)
"Multiple causes of neuropathic pain have been described and its incidence is likely to increase owing to the ageing global population, increased incidence of diabetes mellitus and improved survival from cancer after chemotherapy."2.55Neuropathic pain. ( Attal, N; Baron, R; Bennett, DL; Bouhassira, D; Colloca, L; Dickenson, AH; Dworkin, RH; Eccleston, C; Finnerup, NB; Freeman, R; Kalso, E; Ludman, T; Raja, SN; Truini, A; Yarnitsky, D, 2017)
"Neuropathic pain is caused by a lesion or disease of the somatosensory system, including peripheral fibres (Aβ, Aδ and C fibres) and central neurons, and affects 7-10% of the general population."2.55Neuropathic pain. ( Attal, N; Baron, R; Bennett, DL; Bouhassira, D; Colloca, L; Dickenson, AH; Dworkin, RH; Eccleston, C; Finnerup, NB; Freeman, R; Kalso, E; Ludman, T; Raja, SN; Truini, A; Yarnitsky, D, 2017)
"Corticosterone (CORT) is a glucocorticoid produced by adrenal glands under the control of the hypothalamic-pituitary-adrenal axis."1.42Corticosterone analgesia is mediated by the spinal production of neuroactive metabolites that enhance GABAergic inhibitory transmission on dorsal horn rat neurons. ( Anton, F; Darbon, P; Hanesch, U; Juif, PÉ; Poisbeau, P; Zell, V, 2015)
" Time-course data for the dose-response effects were analyzed using two-way analysis of variance and the posthoc Tukey-Kramer multiple-comparison test."1.40Antinociceptive effects of mirtazapine, pregabalin, and gabapentin after chronic constriction injury of the infraorbital nerve in rats. ( Hashimoto, R; Hosokawa, K; Mashimo, T; Nakae, A; Nakai, K, 2014)
"Neuropathic pain is currently an insufficiently treated clinical condition."1.40Soluble epoxide hydrolase inhibition is antinociceptive in a mouse model of diabetic neuropathy. ( Hammock, BD; Inceoglu, B; Wagner, K; Yang, J, 2014)
" Noteworthy, the repeated administration of AT-RvD1 and RvD2 also prevented the depressive-like behavior in reserpine-treated animals, according to assessment of immobility time, although the chronic administration of pregabalin failed to affect this parameter."1.40Effects of D-series resolvins on behavioral and neurochemical changes in a fibromyalgia-like model in mice. ( Campos, MM; Klein, CP; Leite, CE; Maciel, IS; Souza, AH; Sperotto, ND, 2014)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's11 (91.67)24.3611
2020's1 (8.33)2.80

Authors

AuthorsStudies
Ryu, SW1
Kim, YO1
Kim, HB1
Oh, SB2
Choi, JI1
Yoon, MH1
Lee, PR1
Yoon, SY1
Kim, HW1
Yeo, JH1
Kim, YH1
García-Hernández, L1
Navarrete-Vázquez, G1
González-Trujano, ME1
López-Muñoz, FJ1
Déciga-Campos, M1
Enomoto, R1
Tsukamoto, M1
Shimoshige, Y1
Aoki, T1
Matsuoka, N1
Nakai, K1
Nakae, A1
Hashimoto, R1
Mashimo, T1
Hosokawa, K1
Wagner, K1
Yang, J1
Inceoglu, B1
Hammock, BD1
Klein, CP1
Sperotto, ND1
Maciel, IS1
Leite, CE1
Souza, AH1
Campos, MM1
Nakama-Kitamura, M1
Zell, V1
Juif, PÉ1
Hanesch, U1
Poisbeau, P1
Anton, F1
Darbon, P1
Adães, S1
Ferreira-Gomes, J1
Mendonça, M1
Almeida, L1
Castro-Lopes, JM1
Neto, FL1
Colloca, L1
Ludman, T1
Bouhassira, D1
Baron, R1
Dickenson, AH1
Yarnitsky, D1
Freeman, R1
Truini, A1
Attal, N1
Finnerup, NB1
Eccleston, C1
Kalso, E1
Bennett, DL1
Dworkin, RH1
Raja, SN1
Vedula, SS1
Goldman, PS1
Rona, IJ1
Greene, TM1
Dickersin, K1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
BotulInum Toxin Type A for Peripheral Neuropathic Pain in subjEcts With Carpal Tunnel Syndrome: a Multicenter, Randomized, Doubleblind, Placebo-controlled Study[NCT05411900]Phase 2164 participants (Anticipated)Interventional2022-05-25Recruiting
Hypogastric Plexus Block and Ganglion Impar Block for Cervical and Endometrial Cancer Pain Management: A Randomized Controlled Trial of Efficacy and Safety[NCT05427058]36 participants (Anticipated)Interventional2022-08-01Not yet recruiting
Neuropathic Foot and Ankle in Rheumatoid Arthritis : Ultrasound and Nerve Conduction Study[NCT04550884]80 participants (Anticipated)Observational2020-10-31Not yet recruiting
NanaBis™ an Oro-buccal Administered Equimolar d9-THC & CBD Formulation as Monotherapy for Management of Opioid Requiring Bone Pain Due to Metastatic Cancer: Phase 3 Multi Centre Blinded Randomized Withdrawal Active & Placebo Controlled Trial[NCT04808531]Phase 3360 participants (Anticipated)Interventional2023-11-30Not yet recruiting
Diode Laser as a Biomarker for Neuropathic Pain of Peripheral Origin.[NCT06030297]301 participants (Anticipated)Interventional2022-11-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for gamma-aminobutyric acid and Nociceptive Pain

ArticleYear
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017
Neuropathic pain.
    Nature reviews. Disease primers, 2017, Feb-16, Volume: 3

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Gabapentin; gamma-Aminob

2017

Other Studies

11 other studies available for gamma-aminobutyric acid and Nociceptive Pain

ArticleYear
Antinociceptive effect of intrathecal P7C3 via GABA in a rat model of inflammatory pain.
    European journal of pharmacology, 2021, May-15, Volume: 899

    Topics: Analgesics; Animals; Calcium Signaling; Carbazoles; Disease Models, Animal; Formaldehyde; gamma-Amin

2021
Peripheral GABA
    Neuropharmacology, 2018, Volume: 135

    Topics: Animals; Antibodies; Freund's Adjuvant; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma

2018
Antihyperalgesic activity of a novel synthesized analogue of lidocaine in diabetic rats.
    The Journal of pharmacy and pharmacology, 2013, Volume: 65, Issue:5

    Topics: Amines; Analgesics; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Diabetes Complications;

2013
New index of pain triggered by spinal activation of voltage-dependent sodium channels.
    Journal of anesthesia, 2013, Volume: 27, Issue:6

    Topics: Amitriptyline; Animals; gamma-Aminobutyric Acid; Injections, Spinal; Lidocaine; Male; Mexiletine; Mi

2013
Antinociceptive effects of mirtazapine, pregabalin, and gabapentin after chronic constriction injury of the infraorbital nerve in rats.
    Journal of oral & facial pain and headache, 2014,Winter, Volume: 28, Issue:1

    Topics: Adrenergic alpha-Antagonists; Amines; Analgesics; Animals; Cranial Nerve Injuries; Cyclohexanecarbox

2014
Soluble epoxide hydrolase inhibition is antinociceptive in a mouse model of diabetic neuropathy.
    The journal of pain, 2014, Volume: 15, Issue:9

    Topics: Amines; Analgesics; Animals; Benzoates; Chronic Pain; Conditioning, Psychological; Cyclohexanecarbox

2014
Effects of D-series resolvins on behavioral and neurochemical changes in a fibromyalgia-like model in mice.
    Neuropharmacology, 2014, Volume: 86

    Topics: Analgesics; Animals; Antidepressive Agents; Brain; Depression; Disease Models, Animal; Docosahexaeno

2014
The distinctive significance of analgesic drugs and olfactory stimulants on learned pain in mice.
    Brain research, 2014, Nov-07, Volume: 1588

    Topics: Acetaminophen; Amines; Analgesics; Animals; Conditioning, Psychological; Cyclohexanecarboxylic Acids

2014
Corticosterone analgesia is mediated by the spinal production of neuroactive metabolites that enhance GABAergic inhibitory transmission on dorsal horn rat neurons.
    The European journal of neuroscience, 2015, Volume: 41, Issue:3

    Topics: Animals; Blood Chemical Analysis; Corticosterone; Desoxycorticosterone; gamma-Aminobutyric Acid; Mic

2015
Injury of primary afferent neurons may contribute to osteoarthritis induced pain: an experimental study using the collagenase model in rats.
    Osteoarthritis and cartilage, 2015, Volume: 23, Issue:6

    Topics: Amines; Analgesics; Animals; Arthritis, Experimental; Calcium Channels; Calcium Channels, L-Type; Co

2015
Implementation of a publication strategy in the context of reporting biases. A case study based on new documents from Neurontin litigation.
    Trials, 2012, Aug-13, Volume: 13

    Topics: Access to Information; Amines; Analgesics; Antimanic Agents; Authorship; Bipolar Disorder; Clinical

2012