gamma-aminobutyric acid and Nervous System Disorders studies

gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.

Research Excerpts

Excerpt	Relevance	Reference
"To evaluate the analgesic effectiveness and adverse effects of gabapentin for pain management in clinical practice."	8.82	Gabapentin for acute and chronic pain. ( Edwards, JE; McQuay, HJ; Moore, RA; Wiffen, PJ, 2005)
"There is evidence to show that gabapentin is effective in neuropathic pain."	8.82	Gabapentin for acute and chronic pain. ( Edwards, JE; McQuay, HJ; Moore, RA; Wiffen, PJ, 2005)
"Randomised trials of gabapentin in acute, chronic or cancer pain were identified by MEDLINE (1966-Nov 2004), EMBASE (1994-Nov 2004), SIGLE (1980-Jan 2004) and the Cochrane Central Register of Controlled Trials (CENTRAL) (Cochrane Library Issue 4, 2004)."	8.82	Gabapentin for acute and chronic pain. ( Edwards, JE; McQuay, HJ; Moore, RA; Wiffen, PJ, 2005)
"Randomised trials reporting the analgesic effects of gabapentin in patients, with subjective pain assessment as either the primary or a secondary outcome."	8.82	Gabapentin for acute and chronic pain. ( Edwards, JE; McQuay, HJ; Moore, RA; Wiffen, PJ, 2005)
"Although its exact mode of action is not known, gabapentin appears to have a unique effect on voltage-dependent calcium ion channels at the postsynaptic dorsal horns and may, therefore, interrupt the series of events that possibly leads to the experience of a neuropathic pain sensation."	8.81	Gabapentin: pharmacology and its use in pain management. ( Kam, PC; Rose, MA, 2002)
"Gabapentin is a gamma-aminobutyric acid analog used for numerous neurologic conditions, including neuropathic pain and epilepsy."	7.75	Gabapentin therapy for pain and irritability in a neurologically impaired infant. ( Cox, TH; Garner, SS; Haney, AL, 2009)
"The objective of this study was to assess the efficacy and safety of Gabapentin as the sole analgesic in patients with HIV-related painful neuropathy."	7.71	Gabapentin in painful HIV-related neuropathy: a report of 19 patients, preliminary observations. ( Bottura, P; La Spina, I; Maggiolo, F; Porazzi, D; Suter, F, 2001)
"Patients with amyotrophic lateral sclerosis have increased levels of the neutrotransmitter norepinephrine in blood and cerebrospinal fluid and depressed levels of the inhibitory neurotransmitter gamma-aminobutyric acid in cerebrospinal fluid."	7.66	Norepinephrine and gamma-aminobutyric acid in amyotrophic lateral sclerosis. ( Brooks, BR; Enna, SJ; Lake, CR; Wood, JH; Ziegler, MG, 1980)
"Gabapentin has been clearly demonstrated to be effective for the treatment of neuropathic pain in diabetic neuropathy and postherpetic neuralgia."	6.41	Gabapentin: pharmacology and its use in pain management. ( Kam, PC; Rose, MA, 2002)
"Gabapentin is a gamma-aminobutyric acid analog used for numerous neurologic conditions, including neuropathic pain and epilepsy."	5.35	Gabapentin therapy for pain and irritability in a neurologically impaired infant. ( Cox, TH; Garner, SS; Haney, AL, 2009)
" The infant continued to receive gabapentin; the dosage was increased to 10 mg/kg at bedtime after 6 days, then to 5 mg/kg in the morning and 10 mg/kg at bedtime 10 days later."	5.35	Gabapentin therapy for pain and irritability in a neurologically impaired infant. ( Cox, TH; Garner, SS; Haney, AL, 2009)
"A variety of treatments for the pain were ineffective."	5.30	Gabapentin for treatment of neuropathic pain in a 12-year-old girl. ( McGraw, T; Stacey, BR, 1998)
"There is evidence to show that gabapentin is effective in neuropathic pain."	4.82	Gabapentin for acute and chronic pain. ( Edwards, JE; McQuay, HJ; Moore, RA; Wiffen, PJ, 2005)
"Randomised trials of gabapentin in acute, chronic or cancer pain were identified by MEDLINE (1966-Nov 2004), EMBASE (1994-Nov 2004), SIGLE (1980-Jan 2004) and the Cochrane Central Register of Controlled Trials (CENTRAL) (Cochrane Library Issue 4, 2004)."	4.82	Gabapentin for acute and chronic pain. ( Edwards, JE; McQuay, HJ; Moore, RA; Wiffen, PJ, 2005)
"To evaluate the analgesic effectiveness and adverse effects of gabapentin for pain management in clinical practice."	4.82	Gabapentin for acute and chronic pain. ( Edwards, JE; McQuay, HJ; Moore, RA; Wiffen, PJ, 2005)
"Randomised trials reporting the analgesic effects of gabapentin in patients, with subjective pain assessment as either the primary or a secondary outcome."	4.82	Gabapentin for acute and chronic pain. ( Edwards, JE; McQuay, HJ; Moore, RA; Wiffen, PJ, 2005)
"Although its exact mode of action is not known, gabapentin appears to have a unique effect on voltage-dependent calcium ion channels at the postsynaptic dorsal horns and may, therefore, interrupt the series of events that possibly leads to the experience of a neuropathic pain sensation."	4.81	Gabapentin: pharmacology and its use in pain management. ( Kam, PC; Rose, MA, 2002)
"Gabapentin is a gamma-aminobutyric acid analog used for numerous neurologic conditions, including neuropathic pain and epilepsy."	3.75	Gabapentin therapy for pain and irritability in a neurologically impaired infant. ( Cox, TH; Garner, SS; Haney, AL, 2009)
"Gabapentin is an antiepileptic drug approved for the treatment of postherpetic neuralgia and as adjunctive therapy for partial seizures."	3.73	Gabapentin-induced neurologic toxicities. ( Bookwalter, T; Gitlin, M, 2005)
"The objective of this study was to assess the efficacy and safety of Gabapentin as the sole analgesic in patients with HIV-related painful neuropathy."	3.71	Gabapentin in painful HIV-related neuropathy: a report of 19 patients, preliminary observations. ( Bottura, P; La Spina, I; Maggiolo, F; Porazzi, D; Suter, F, 2001)
"The anticonvulsant gabapentin is effective against neuropathic pain, but the primary site(s) and mechanism(s) of action are unknown."	3.70	Antinociceptive effect of systemic gabapentin in mononeuropathic rats, depends on stimulus characteristics and level of test integration. ( Christensen, D; Kayser, V, 2000)
"The effects of N-(2,6-dimethyl-phenyl)-2-(2-oxo-1-pyrrolidinyl)acetamide (DM-9384), a cyclic derivative of GABA, were investigated and compared with those of aniracetam in an animal model of amnesia, using a passive avoidance task with animals that have GABAergic neuronal dysfunctions."	3.68	Effects of DM-9384 in a model of amnesia based on animals with GABAergic neuronal dysfunctions. ( Itoh, J; Kameyama, T; Nabeshima, T; Noda, Y; Tohyama, K, 1990)
"Patients with amyotrophic lateral sclerosis have increased levels of the neutrotransmitter norepinephrine in blood and cerebrospinal fluid and depressed levels of the inhibitory neurotransmitter gamma-aminobutyric acid in cerebrospinal fluid."	3.66	Norepinephrine and gamma-aminobutyric acid in amyotrophic lateral sclerosis. ( Brooks, BR; Enna, SJ; Lake, CR; Wood, JH; Ziegler, MG, 1980)
"Of 200 consecutive breast cancer patients, 191 received the full package."	2.75	Multimodal prevention of pain, nausea and vomiting after breast cancer surgery. ( Callesen, T; Gärtner, R; Kehlet, H; Kroman, N, 2010)
"Gamma-aminobutyric acid (Gaba) is a non-proteinogenic amino acid that is widely present in microorganisms, plants, and vertebrates."	2.61	An Updated Review on Pharmaceutical Properties of Gamma-Aminobutyric Acid. ( Ngo, DH; Vo, TS, 2019)
"Numerous neurological disorders are caused by a dysfunction of the GABAergic system that impairs or either stimulates its inhibitory action over its neuronal targets."	2.47	GABAergic neuronal precursor grafting: implications in brain regeneration and plasticity. ( Alvarez Dolado, M; Broccoli, V, 2011)
"Epileptic myoclonus is that which forms part of an epileptic syndrome with a genetic or idiopathic cause, or that is due to static encephalopathy."	2.45	[Myoclonic spasms: their clinical and neurophysiological characteristics, aetiology and treatment]. ( Erro, ME; Navarro, MC, 2009)
"So-called symptomatic myoclonus is the type that occurs secondary to an identifiable disorder; it is usually accompanied by other neurological signs and is the most frequent kind."	2.45	[Myoclonic spasms: their clinical and neurophysiological characteristics, aetiology and treatment]. ( Erro, ME; Navarro, MC, 2009)
"Neuropathic cranial pain, i."	2.42	Neuropathic cranial pain. ( Annovazzi, PO; Colombo, B; Comi, G, 2003)
"Lamotrigine has been reported to be effective in relieving pain from trigeminal neuralgia refractory to other treatments, HIV neuropathy, and central post-stroke pain."	2.41	Use of anticonvulsants for treatment of neuropathic pain. ( Backonja, MM, 2002)
"Gabapentin has demonstrated efficacy, specifically in painful diabetic neuropathy and postherpetic neuralgia."	2.41	Use of anticonvulsants for treatment of neuropathic pain. ( Backonja, MM, 2002)
"Gabapentin has been clearly demonstrated to be effective for the treatment of neuropathic pain in diabetic neuropathy and postherpetic neuralgia."	2.41	Gabapentin: pharmacology and its use in pain management. ( Kam, PC; Rose, MA, 2002)
"Vigabatrin was designed to increase the levels of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) in the brain."	2.39	A risk-benefit assessment of vigabatrin in the treatment of neurological disorders. ( Richens, A; Srinivasan, J, 1994)
" Adverse effects of antiepileptic treatment may affect the patient's quality of life to an even greater extent than the occurrence of seizures."	2.39	Adverse effects of established and new antiepileptic drugs: an attempted comparison. ( Gram, L; Rogvi-Hansen, B, 1995)
"Gamma-aminobutyric acid (GABA) is a major modulator in brain maturation and its role in many different neurodevelopmental disorders has been widely reported."	1.48	Gamma-aminobutyric acid levels in cerebrospinal fluid in neuropaediatric disorders. ( Armstrong-Morón, J; Artuch, R; Casado, M; Cortès-Saladelafont, E; Cuadras, D; García-Cazorla, À; Molero-Luis, M; Montoya, J; Yubero, D, 2018)
" The infant continued to receive gabapentin; the dosage was increased to 10 mg/kg at bedtime after 6 days, then to 5 mg/kg in the morning and 10 mg/kg at bedtime 10 days later."	1.35	Gabapentin therapy for pain and irritability in a neurologically impaired infant. ( Cox, TH; Garner, SS; Haney, AL, 2009)
"Gabapentin is a gamma-aminobutyric acid analog used for numerous neurologic conditions, including neuropathic pain and epilepsy."	1.35	Gabapentin therapy for pain and irritability in a neurologically impaired infant. ( Cox, TH; Garner, SS; Haney, AL, 2009)
"Gabapentin is an antiepileptic drug approved for the treatment of postherpetic neuralgia and as adjunctive therapy for partial seizures."	1.33	Gabapentin-induced neurologic toxicities. ( Bookwalter, T; Gitlin, M, 2005)
"A variety of treatments for the pain were ineffective."	1.30	Gabapentin for treatment of neuropathic pain in a 12-year-old girl. ( McGraw, T; Stacey, BR, 1998)
"gamma-Aminobutyric acid (GABA) was measured in CSF as such and following acid hydrolysis by the ion-exchange/fluorometric method."	1.27	Free and conjugated GABA in human cerebrospinal fluid: effect of degenerative neurologic diseases and isoniazid. ( Manyam, BV; Tremblay, RD, 1984)
"In patients with Huntington's disease, on administration of isoniazid at 900 mg/day, along with pyridoxine at 100 mg/day, a 4-fold increase of both free (P less than 0."	1.27	Free and conjugated GABA in human cerebrospinal fluid: effect of degenerative neurologic diseases and isoniazid. ( Manyam, BV; Tremblay, RD, 1984)
"gamma-Aminobutyric acid (GABA) levels were measured by a radioreceptor assay in cerebrospinal fluid (CSF) specimens from two groups of subjects, one without evidence of neurological or psychiatric disease and one with a variety of neurological disorders for which GABA involvement is not known."	1.27	Monitoring of gamma-aminobutyric acid in human cerebrospinal fluid: downward revision of previous control values. ( Löscher, W; Schmidt, D, 1984)
"In 49 patients with various neurological disorders plasma and CSF gamma-aminobutyric acid (GABA) concentrations were determined by radioreceptor assay."	1.26	Plasma and cerebrospinal fluid gamma-aminobutyric acid in neurological disorders. ( Löscher, W; Schmidt, D, 1982)

Research

Studies (114)

Authors

Clinical Trials (9)

Trial Overview

Trial Outcomes

Prefrontal GABA+ Concentrations

Timeframe	Studies, this research(%)	All Research%
pre-1990	35 (30.70)	18.7374
1990's	20 (17.54)	18.2507
2000's	24 (21.05)	29.6817
2010's	31 (27.19)	24.3611
2020's	4 (3.51)	2.80

Authors	Studies
Kasatkina, LA	1
Tarasenko, AS	1
Krupko, OO	1
Kuchmerovska, TM	1
Lisakovska, OO	1
Trikash, IO	1
Carriere, CH	1
Wang, WX	1
Sing, AD	1
Fekete, A	1
Jones, BE	1
Yee, Y	1
Ellegood, J	1
Maganti, H	1
Awofala, L	1
Marocha, J	1
Aziz, A	1
Wang, LY	1
Lerch, JP	1
Lefebvre, JL	1
Kim, HK	1
Blumberger, DM	1
Downar, J	1
Daskalakis, ZJ	1
Chhabra, H	1
Thimmashetty, VH	1
Shivakumar, V	1
Venkatasubramanian, G	1
Narayanswamy, JC	1
Daghestani, MH	1
Selim, ME	1
Abd-Elhakim, YM	1
Said, EN	1
El-Hameed, NEA	1
Khalil, SR	1
El-Tawil, OS	1
Bondar, T	1
Carmona, J	1
Gao, K	1
Benedetti, B	1
Basson, M	1
Levinson, R	1
Stower, H	1
Farrell, A	1
Fontes, MAP	1
Vaz, GC	1
Cardoso, TZD	1
de Oliveira, MF	1
Campagnole-Santos, MJ	1
Dos Santos, RAS	1
Sharma, NM	1
Patel, KP	1
Frézard, F	1
Revol, B	1
Jullian-Desayes, I	1
Bailly, S	1
Mallaret, M	1
Tamisier, R	1
Agier, MS	1
Lador, F	1
Joyeux-Faure, M	1
Pépin, JL	1
Cortès-Saladelafont, E	1
Molero-Luis, M	1
Cuadras, D	1
Casado, M	1
Armstrong-Morón, J	1
Yubero, D	1
Montoya, J	1
Artuch, R	1
García-Cazorla, À	1
Baizabal-Carvallo, JF	1
Ngo, DH	1
Vo, TS	1
Alexopoulos, H	1
Dalakas, MC	1
Costin, BN	1
Miles, MF	1
Xu, H	1
Wang, Y	1
He, Z	1
Yang, H	1
Gao, WQ	1
Yoneda, Y	1
Bjørn-Yoshimoto, WE	1
Underhill, SM	1
Calandre, EP	1
Rico-Villademoros, F	1
Slim, M	1
Kondziella, D	1
Bannwarth, B	1
Erro, ME	1
Navarro, MC	1
Nebbioso, M	1
D'Innocenzo, D	1
Rapone, S	1
Di Benedetto, G	1
Grenga, R	1
Haney, AL	1
Garner, SS	1
Cox, TH	1
Tanii, H	1
Higashi, T	1
Saijoh, K	1
Kohtz, JD	1
Berghoff, EG	1
Gajcy, K	1
Lochyński, S	1
Librowski, T	1
Gärtner, R	1
Kroman, N	1
Callesen, T	1
Kehlet, H	1
Wiffen, PJ	2
McQuay, HJ	2
Edwards, J	1
Moore, RA	2
Alvarez Dolado, M	1
Broccoli, V	1
Singh, H	1
Wang, MY	1
Chattopadhyaya, B	1
Masiulis, I	1
Yun, S	1
Eisch, AJ	1
Dahmani, S	1
Tourrel, F	1
Blanc, T	1
Marret, S	1
Jegou-Colleter, S	1
Laudenbach, V	1
McCarthy, MM	1
Ching, S	1
Whittington, MA	1
Kopell, N	1
Subburaju, S	1
Benes, FM	2
Ben-Ari, Y	1
Khalilov, I	1
Kahle, KT	1
Cherubini, E	1
Gassmann, M	1
Bettler, B	1
Peng, P	1
Xi, Q	1
Xia, S	1
Zhuang, L	1
Gui, Q	1
Chen, Y	1
Huang, Y	1
Zou, M	1
Rao, J	1
Yu, S	1
Persheim, MS	1
Helland, A	1
Spigset, O	1
Slørdal, L	1
Backonja, MM	1
Chang, L	1
Cloak, CC	1
Ernst, T	1
Colombo, B	1
Annovazzi, PO	1
Comi, G	1
Wong, CG	1
Bottiglieri, T	1
Snead, OC	1
Staley, K	1
FEITELEVICH, J	1
BLEI, M	1
LEVIN, E	1
Smith, DE	1
Xu, SG	1
Pearl, PL	1
Wallis, DD	1
Gibson, KM	1
Conti, F	1
Minelli, A	1
Melone, M	1
Santhakumar, V	1
Soltesz, I	1
Liu, W	2
He, X	2
Cao, Z	2
Sheng, J	1
Liu, H	1
Li, Z	1
Li, W	2
Edwards, JE	1
Bookwalter, T	1
Gitlin, M	1
De Koninck, Y	1
Hauer, JM	1
Wical, BS	1
Charnas, L	1
Liu, Z	1
Cao, X	1
Xue, L	1
Zhu, F	1
Neethling, AC	1
McCarthy, B	1
Taljaard, JJ	1
Silbergeld, EK	1
Lamon, JM	1
Wray, SR	1
Melville, GN	1
Grell, GA	1
Edge, PC	1
Krogsgaard-Larsen, P	1
Hall, ED	1
Stewart, CM	1
Coyle, JT	1
Singer, H	1
Beaulieu, M	1
Johnston, MV	1
Manyam, BV	2
Tremblay, RD	1
Hammond, EJ	1
Wilder, BJ	1
Bruni, J	1
Skorka, G	1
Bien, E	1
Manyam, NV	1
Katz, L	1
Hare, TA	3
Gerber, JC	1
Grossman, MH	1
Enna, SJ	2
Ho, IK	1
Fernando, JC	1
Sivam, SP	1
Hoskins, B	1
Löscher, W	2
Schmidt, D	2
Bonkowsky, HL	1
Schady, W	1
Prusiner, SB	1
Kuroda, H	1
Ogawa, N	1
Yamawaki, Y	1
Nukina, I	1
Ofuji, T	1
Yamamoto, M	1
Otsuki, S	1
Ziegler, MG	1
Brooks, BR	1
Lake, CR	1
Wood, JH	2
Jakobs, C	1
Bojasch, M	1
Mönch, E	1
Rating, D	1
Siemes, H	1
Hanefeld, F	1
Abbott, RJ	1
Keidan, J	1
Pye, IF	1
Nahorski, SR	1
Uziel, G	1
Bardelli, P	1
Pantaleoni, C	1
Rimoldi, M	1
Savoiardo, M	1
Kryzhanovskiĭ, GN	1
Danilova, EI	1
Grafova, VN	1
Reshetniak, VK	1
Rahbeeni, Z	1
Ozand, PT	1
Rashed, M	1
Gascon, GG	1
al Nasser, M	1
al Odaib, A	1
Amoudi, M	1
Nester, M	1
al Garawi, S	1
Brismar, J	1
Srinivasan, J	1
Richens, A	1
Naini, AB	1
Vontzalidou, E	1
Côté, LJ	1
Rogvi-Hansen, B	1
Gram, L	1
Rapallino, MV	1
Cupello, A	1
Leonardi, A	1
Mikhaĭlenko, AA	1
Odinak, MM	1
Ivanov, IuS	1
Kotel'nikov, SA	1
Semin, GF	1
Shustov, EB	1
Timmerman, W	1
Westerink, BH	1
Fadda, F	1
Rossetti, ZL	1
McGraw, T	1
Stacey, BR	1
Kawai, N	1
Taylor, JB	1
Cunningham, MC	1
Kayser, V	1
Christensen, D	1
Miyamoto, Y	1
Yamada, K	1
Noda, Y	2
Mori, H	1
Mishina, M	1
Nabeshima, T	2
La Spina, I	1
Porazzi, D	1
Maggiolo, F	1
Bottura, P	1
Suter, F	1
Rose, MA	1
Kam, PC	1
Achar, VS	1
Welch, KM	1
Chabi, E	1
Bartosh, K	1
Meyer, JS	1
Rosa, A	1
Lloyd, KG	1
Dreksler, S	1
Shemen, L	1
Davidson, L	1
Makeeva, VL	1
Gotesgeld, Z	1
Nyberg-Hansen, R	1
Airaksinen, MM	1
Alho, H	1
Keinänen, K	1
Tomoda, H	1
Kato, M	1
Sakata, S	1
Shima, F	1
Baekkeskov, S	1
Aanstoot, HJ	1
Christgau, S	1
Reetz, A	1
Solimena, M	1
Cascalho, M	1
Folli, F	1
Richter-Olesen, H	1
De Camilli, P	1
Camilli, PD	1
Walkley, SU	1
Baker, HJ	1
Rattazzi, MC	1
Haskins, ME	1
Wu, JY	1
Schechter, PJ	1
Sjoerdsma, A	1
Kamisaki, Y	1
Takao, Y	1
Itoh, T	1
Shimomura, T	1
Takahashi, K	1
Uehara, N	1
Yoshino, Y	1
Tohyama, K	1
Itoh, J	1
Kameyama, T	1
Armijo, JA	1
Khaunina, RA	1
Lapin, IP	1
Strain, GM	1
Flory, W	1
de Yebenes, JG	1
Vazquez, A	1
Martinez, A	1
Mena, MA	1
del Rio, RM	1
de Felipe, C	1
del Rio, J	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Psychosocial and Psychophysical Factors Influencing the Effect of Preemptive Systemic Analgesia in Combination With Regional Anesthesia on Postoperative Pain Following Upper Limb Surgery[NCT05248152]		90 participants (Anticipated)	Interventional	2022-01-13	Recruiting
Combined General Anesthesia Plus Paravertebral Block Versus General Anesthesia Plus Opioid Analgesia for Breast Cancer Surgery: A Prospective Randomized Trial[NCT01904266]		60 participants (Actual)	Interventional	2013-05-31	Completed
Multimodal Pain Treatment for Breast Cancer Surgery - a Prospective Cohort Study[NCT04875559]		236 participants (Actual)	Observational [Patient Registry]	2021-04-19	Completed
Remote Effects of Stroke on Cerebral Metabolism. Evaluation With Positron Emission Tomography and Proton Magnetic Resonance Spectroscopy[NCT00063180]		70 participants	Observational	2003-06-19	Completed
A Phase II, Randomized, Placebo-controlled, Double Blind, Cross-over, Study of the Effects of Gabapentin on Chronic Irritability in Neurologically Impaired Children[NCT01675960]	Phase 2	2 participants (Actual)	Interventional	2012-04-30	Terminated (stopped due to unable to enroll)
Diode Laser as a Biomarker for Neuropathic Pain of Peripheral Origin.[NCT06030297]		301 participants (Anticipated)	Interventional	2022-11-01	Recruiting
Imaging Framework for Testing GABAergic/Glutamatergic Drugs in Bipolar Alcoholics[NCT03220776]	Phase 2	54 participants (Actual)	Interventional	2017-08-07	Completed
Gabapentin for Pain Control After Osmotic Dilator Insertion and Prior to D&E Procedure: a Randomized Controlled Trial[NCT03080493]	Phase 4	121 participants (Actual)	Interventional	2017-03-20	Completed
Gabapentin as a Pre-emptive Analgesic in Oral and Maxillofacial Surgical Procedures[NCT02957097]	Phase 4	0 participants (Actual)	Interventional	2019-09-30	Withdrawn (stopped due to Original PI left institution and the PI who took over was not able to initiate the study so it was never started.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Concentrations of GABA+, referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy (i.e., MEGA-PRESS). (NCT03220776)
Timeframe: Day 5 of each experimental condition

Prefrontal Glx Concentrations

Intervention	mmol/kg (Mean)
N-Acetylcysteine	3.90
Gabapentin	3.93
Placebo Oral Tablet	3.73

Concentrations of Glx (i.e., glutamate + glutamine), referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy. (NCT03220776)
Timeframe: Day 5 of each experimental condition

Mean Change From Baseline in NRS Pain Score at 2 Hours After Dilator Insertion

Intervention	mmol/kg (Mean)
N-Acetylcysteine	21.59
Gabapentin	21.69
Placebo Oral Tablet	22.25

Pain score based on numeric rating scale (NRS [0 lowest value to 10 highest value, in which 0 is the lowest amount of pain and 10 is the highest amount of pain]); Baseline obtained prior to study drug ingestion/dilator insertion. NRS pain score obtained via text message. (NCT03080493)
Timeframe: 2 hours after insertion of last osmotic dilator

Mean Change From Baseline in NRS Pain Score at 4 Hours After Dilator Insertion

Intervention	Numeric rating scale pain score change (Median)
Gabapentin	3.5
Placebo Oral Capsule	4

Mean Change From Baseline in NRS Pain Score at 5 Minutes After Last Dilator Insertion

Intervention	Numeric rating scale pain score change (Mean)
Gabapentin	3
Placebo Oral Capsule	3.5

Pain score based on numeric rating scale (NRS [0 lowest value to 10 highest value, in which 0 is the lowest amount of pain and 10 is the highest amount of pain]); Baseline obtained prior to study drug ingestion/dilator insertion. NRS pain score obtained in person before subject leaves clinic appointment. (NCT03080493)
Timeframe: 5 minutes after insertion of last osmotic dilator

Mean Change From Baseline in NRS Pain Score at 8 Hours After Dilator Insertion

Intervention	Numeric rating scale pain score change (Median)
Gabapentin	1
Placebo Oral Capsule	2

Mean Change From Baseline in NRS Pain Score at Time of Presentation for D&E Procedure (Day Following Dilator Insertion)

Intervention	Numeric rating scale pain score change (Median)
Gabapentin	2
Placebo Oral Capsule	2.5

Pain score based on numeric rating scale (NRS [0 lowest value to 10 highest value, in which 0 is the lowest amount of pain and 10 is the highest amount of pain]); Baseline obtained prior to study drug ingestion/dilator insertion. NRS pain score obtained in person upon presentation for D&E procedure. (NCT03080493)
Timeframe: Time of presentation for D&E (day after dilator insertion)

Number of Participants Using Narcotic Pain Medication (Acetaminophen/Codeine)

Intervention	Numeric rating scale pain score change (Median)
Gabapentin	0.5
Placebo Oral Capsule	1

Subject account of how many used acetaminophen/codeine (standard medications given for supplement NSAID as needed after dilator insertion) (NCT03080493)
Timeframe: Collected between each subject contact (2 hours, 4 hours, 8 hours after dilator insertion and at time of presentation for D&E procedure)

Reviews

Trials

Other Studies

61 other studies available for gamma-aminobutyric acid and Nervous System Disorders

Article	Year
Systematic review of biological markers of therapeutic repetitive transcranial magnetic stimulation in neurological and psychiatric disorders. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2021, Volume: 132, Issue:2 Topics: beta-Endorphin; Biomarkers; Brain-Derived Neurotrophic Factor; gamma-Aminobutyric Acid; Humans; Ment	2021
Effect of transcranial direct current stimulation on in-vivo assessed neuro-metabolites through magnetic resonance spectroscopy: a systematic review. Acta neuropsychiatrica, 2021, Volume: 33, Issue:5 Topics: Adult; Aged; Case-Control Studies; Cerebellar Cortex; Dorsolateral Prefrontal Cortex; Female; gamma-	2021
GABA-containing liposomes: neuroscience applications and translational perspectives for targeting neurological diseases. Nanomedicine : nanotechnology, biology, and medicine, 2018, Volume: 14, Issue:3 Topics: Animals; Drug Delivery Systems; gamma-Aminobutyric Acid; Humans; Liposomes; Nervous System Diseases	2018
The neurological syndromes associated with glutamic acid decarboxylase antibodies. Journal of autoimmunity, 2019, Volume: 101 Topics: Autoantibodies; Autoimmune Diseases; Autoimmunity; Brain; Combined Modality Therapy; Disease Suscept	2019
An Updated Review on Pharmaceutical Properties of Gamma-Aminobutyric Acid. Molecules (Basel, Switzerland), 2019, Jul-24, Volume: 24, Issue:15 Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Antihypertensive Agents; Antineoplastic Ag	2019
Disease mechanisms. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2013, Volume: 19, Issue:5 Topics: Animals; Behavior; Brain; Connexins; gamma-Aminobutyric Acid; Humans; Migraine Disorders; Nerve Tiss	2013
Immunology of stiff person syndrome and other GAD-associated neurological disorders. Expert review of clinical immunology, 2013, Volume: 9, Issue:11 Topics: Animals; Autoantibodies; Autoantigens; Autoimmune Diseases of the Nervous System; Biomarkers; Diseas	2013
Molecular and neurologic responses to chronic alcohol use. Handbook of clinical neurology, 2014, Volume: 125 Topics: Alcoholism; Animals; Brain; gamma-Aminobutyric Acid; Humans; Nervous System Diseases; Receptors, GAB	2014
[Glutamic acid as a universal extracellular signal]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 2015, Volume: 35, Issue:4 Topics: Animals; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Homeostasis; Humans; Nervous S	2015
The importance of the excitatory amino acid transporter 3 (EAAT3). Neurochemistry international, 2016, Volume: 98 Topics: Animals; Excitatory Amino Acid Transporter 3; gamma-Aminobutyric Acid; Gene Expression Regulation; H	2016
Alpha Expert review of neurotherapeutics, 2016, Volume: 16, Issue:11 Topics: Amines; Bridged Bicyclo Compounds; Calcium Channel Blockers; Cyclohexanecarboxylic Acids; Gabapentin	2016
The Top 5 Neurotransmitters from a Clinical Neurologist's Perspective. Neurochemical research, 2017, Volume: 42, Issue:6 Topics: Acetylcholine; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Nervous System Diseases; Ne	2017
[Myoclonic spasms: their clinical and neurophysiological characteristics, aetiology and treatment]. Revista de neurologia, 2009, Jan-23, Volume: 48 Suppl 1 Topics: 5-Hydroxytryptophan; Anticonvulsants; Antidepressive Agents, Second-Generation; Diagnosis, Different	2009
[Nystagmus in ophthalmology]. La Clinica terapeutica, 2009, Volume: 160, Issue:2 Topics: Amines; Baclofen; Cyclohexanecarboxylic Acids; Diagnostic Techniques, Ophthalmological; Eye Diseases	2009
A role of GABA analogues in the treatment of neurological diseases. Current medicinal chemistry, 2010, Volume: 17, Issue:22 Topics: Animals; gamma-Aminobutyric Acid; Humans; Nervous System Diseases	2010
WITHDRAWN: Gabapentin for acute and chronic pain. The Cochrane database of systematic reviews, 2011, Mar-16, Issue:3 Topics: Acute Disease; Amines; Analgesics; Anticonvulsants; Chronic Disease; Cyclohexanecarboxylic Acids; ga	2011
GABAergic neuronal precursor grafting: implications in brain regeneration and plasticity. Neural plasticity, 2011, Volume: 2011 Topics: Brain; gamma-Aminobutyric Acid; Humans; Nervous System Diseases; Neuronal Plasticity; Neurons; Regen	2011
Gabapentin reduces experimental secondary neurologic dysfunction in rats. Neurosurgery, 2011, Volume: 68, Issue:4 Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; Nervous S	2011
Molecular mechanisms underlying activity-dependent GABAergic synapse development and plasticity and its implications for neurodevelopmental disorders. Neural plasticity, 2011, Volume: 2011 Topics: Animals; Critical Period, Psychological; Developmental Disabilities; gamma-Aminobutyric Acid; Humans	2011
The interesting interplay between interneurons and adult hippocampal neurogenesis. Molecular neurobiology, 2011, Volume: 44, Issue:3 Topics: Aging; Animals; gamma-Aminobutyric Acid; Hippocampus; Humans; Interneurons; Mental Disorders; Nervou	2011
[Neurological consequences after long-term sedation in the ICU]. Annales francaises d'anesthesie et de reanimation, 2012, Volume: 31, Issue:1 Topics: Aging; Anesthetics, General; Animals; Cesarean Section; Conscious Sedation; Critical Care; Excitator	2012
Dynamical changes in neurological diseases and anesthesia. Current opinion in neurobiology, 2012, Volume: 22, Issue:4 Topics: Anesthesia; Anesthetics; gamma-Aminobutyric Acid; Humans; Models, Neurological; Nerve Net; Nervous S	2012
The GABA excitatory/inhibitory shift in brain maturation and neurological disorders. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2012, Volume: 18, Issue:5 Topics: Animals; Anticonvulsants; Brain; Chlorides; Epilepsy; gamma-Aminobutyric Acid; Humans; Nervous Syste	2012
Regulation of neuronal GABA(B) receptor functions by subunit composition. Nature reviews. Neuroscience, 2012, May-18, Volume: 13, Issue:6 Topics: Animals; Axons; Brain; Dendrites; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic	2012
Use of anticonvulsants for treatment of neuropathic pain. Neurology, 2002, Sep-10, Volume: 59, Issue:5 Suppl 2 Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid;	2002
Magnetic resonance spectroscopy studies of GABA in neuropsychiatric disorders. The Journal of clinical psychiatry, 2003, Volume: 64 Suppl 3 Topics: Anxiety Disorders; Brain; Brain Chemistry; Creatine; Depressive Disorder; Epilepsy; GABA Agents; gam	2003
Neuropathic cranial pain. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2003, Volume: 24 Suppl 2 Topics: Acetates; Amines; Analgesics; Analgesics, Non-Narcotic; Anticonvulsants; Antidepressive Agents, Tric	2003
GABA, gamma-hydroxybutyric acid, and neurological disease. Annals of neurology, 2003, Volume: 54 Suppl 6 Topics: Aldehyde Oxidoreductases; Animals; gamma-Aminobutyric Acid; Humans; Mice; Nervous System Diseases; R	2003
Pediatric neurotransmitter diseases. Current neurology and neuroscience reports, 2004, Volume: 4, Issue:2 Topics: Biogenic Monoamines; Child; gamma-Aminobutyric Acid; Humans; Nervous System Diseases; Neurotransmitt	2004
GABA transporters in the mammalian cerebral cortex: localization, development and pathological implications. Brain research. Brain research reviews, 2004, Volume: 45, Issue:3 Topics: Animals; Animals, Newborn; Carrier Proteins; Cerebral Cortex; Epilepsy; GABA Plasma Membrane Transpo	2004
Plasticity of interneuronal species diversity and parameter variance in neurological diseases. Trends in neurosciences, 2004, Volume: 27, Issue:8 Topics: Animals; gamma-Aminobutyric Acid; Humans; Interneurons; Nerve Net; Nervous System Diseases; Neuronal	2004
Gabapentin for acute and chronic pain. The Cochrane database of systematic reviews, 2005, Jul-20, Issue:3 Topics: Acute Disease; Amines; Analgesics; Anticonvulsants; Chronic Disease; Cyclohexanecarboxylic Acids; Ga	2005
Altered chloride homeostasis in neurological disorders: a new target. Current opinion in pharmacology, 2007, Volume: 7, Issue:1 Topics: Animals; Central Nervous System; Chlorides; gamma-Aminobutyric Acid; Homeostasis; Humans; Microglia;	2007
Current concepts of abnormal motor disorder: an experimental model of attentional deficit disorder. The West Indian medical journal, 1981, Volume: 30, Issue:3 Topics: Amphetamine; Animals; Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Avoidance	1981
gamma-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects. Journal of medicinal chemistry, 1981, Volume: 24, Issue:12 Topics: Analgesics; Animals; Anti-Anxiety Agents; Anticonvulsants; Binding Sites; Biological Transport, Acti	1981
Glucocorticoid effects on central nervous excitability and synaptic transmission. International review of neurobiology, 1982, Volume: 23 Topics: Acetylcholine; Animals; Biomechanical Phenomena; Brain; Cats; Cell Membrane; Central Nervous System;	1982
Central actions of valproic acid in man and in experimental models of epilepsy. Life sciences, 1981, Dec-21, Volume: 29, Issue:25 Topics: 4-Aminobutyrate Transaminase; Action Potentials; Alcohol Oxidoreductases; Aldehyde Oxidoreductases;	1981
[Neurotoxicologic effects of lead and mercury]. Die Pharmazie, 1983, Volume: 38, Issue:11 Topics: Animals; Dopamine; gamma-Aminobutyric Acid; Humans; Lead Poisoning; Mercury Poisoning; Nervous Syste	1983
Neurologic manifestations of acute porphyria. Seminars in liver disease, 1982, Volume: 2, Issue:2 Topics: Acute Disease; Aminolevulinic Acid; Animals; Central Nervous System; Depression; Electrophysiology;	1982
Disorders of glutamate metabolism and neurological dysfunction. Annual review of medicine, 1981, Volume: 32 Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Animals; gamma-Aminobutyric Acid; Glutamates; Glutami	1981
Alterations of central GABAergic activity in neurologic and psychiatric disorders: evaluation through measurements of GABA and GAD activity in cerebrospinal fluid. Molecular and cellular biochemistry, 1981, Sep-25, Volume: 39 Topics: Aging; Carboxy-Lyases; Cold Temperature; Drug Stability; Female; gamma-Aminobutyric Acid; Glutamate	1981
A risk-benefit assessment of vigabatrin in the treatment of neurological disorders. Drug safety, 1994, Volume: 10, Issue:5 Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Brain; Child; Clinical Trials as Topic; Doub	1994
Adverse effects of established and new antiepileptic drugs: an attempted comparison. Pharmacology & therapeutics, 1995, Volume: 68, Issue:3 Topics: Animals; Anticonvulsants; Carbamazepine; Epilepsy; gamma-Aminobutyric Acid; Gastrointestinal Disease	1995
Brain microdialysis of GABA and glutamate: what does it signify? Synapse (New York, N.Y.), 1997, Volume: 27, Issue:3 Topics: Animals; Brain Chemistry; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Microdialysis; Nervous Sys	1997
Chronic ethanol consumption: from neuroadaptation to neurodegeneration. Progress in neurobiology, 1998, Volume: 56, Issue:4 Topics: Acetylcholine; Adaptation, Physiological; Alcohol Amnestic Disorder; Alcohol Drinking; Alcohol-Relat	1998
[Recent topics on amino-acid neurotransmitters]. Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 1999, Volume: 101, Issue:8 Topics: Amino Acid Sequence; Animals; Brain Diseases; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Molecu	1999
Convergence and plasticity of monoaminergic systems in the medial prefrontal cortex during the postnatal period: implications for the development of psychopathology. Cerebral cortex (New York, N.Y. : 1991), 2000, Volume: 10, Issue:10 Topics: Animals; Animals, Newborn; Dopamine; gamma-Aminobutyric Acid; Humans; Mental Disorders; Nervous Syst	2000
Gabapentin: pharmacology and its use in pain management. Anaesthesia, 2002, Volume: 57, Issue:5 Topics: Acetates; Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamm	2002
Gabapentin: pharmacology and its use in pain management. Anaesthesia, 2002, Volume: 57, Issue:5 Topics: Acetates; Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamm	2002
Gabapentin: pharmacology and its use in pain management. Anaesthesia, 2002, Volume: 57, Issue:5 Topics: Acetates; Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamm	2002
Gabapentin: pharmacology and its use in pain management. Anaesthesia, 2002, Volume: 57, Issue:5 Topics: Acetates; Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamm	2002
Gabapentin: pharmacology and its use in pain management. Anaesthesia, 2002, Volume: 57, Issue:5 Topics: Acetates; Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamm	2002
Gabapentin: pharmacology and its use in pain management. Anaesthesia, 2002, Volume: 57, Issue:5 Topics: Acetates; Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamm	2002
Gabapentin: pharmacology and its use in pain management. Anaesthesia, 2002, Volume: 57, Issue:5 Topics: Acetates; Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamm	2002
Gabapentin: pharmacology and its use in pain management. Anaesthesia, 2002, Volume: 57, Issue:5 Topics: Acetates; Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamm	2002
Gabapentin: pharmacology and its use in pain management. Anaesthesia, 2002, Volume: 57, Issue:5 Topics: Acetates; Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamm	2002
Gabapentin: pharmacology and its use in pain management. Anaesthesia, 2002, Volume: 57, Issue:5 Topics: Acetates; Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamm	2002
Gabapentin: pharmacology and its use in pain management. Anaesthesia, 2002, Volume: 57, Issue:5 Topics: Acetates; Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamm	2002
Gabapentin: pharmacology and its use in pain management. Anaesthesia, 2002, Volume: 57, Issue:5 Topics: Acetates; Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamm	2002
Gabapentin: pharmacology and its use in pain management. Anaesthesia, 2002, Volume: 57, Issue:5 Topics: Acetates; Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamm	2002
Gabapentin: pharmacology and its use in pain management. Anaesthesia, 2002, Volume: 57, Issue:5 Topics: Acetates; Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamm	2002
Gabapentin: pharmacology and its use in pain management. Anaesthesia, 2002, Volume: 57, Issue:5 Topics: Acetates; Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamm	2002
Gabapentin: pharmacology and its use in pain management. Anaesthesia, 2002, Volume: 57, Issue:5 Topics: Acetates; Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamm	2002
[Gamma-aminobutyric acid and its receptors--from molecular biology to clinical medicine]. Duodecim; laaketieteellinen aikakauskirja, 1990, Volume: 106, Issue:22 Topics: Animals; Barbiturates; Benzodiazepines; Clinical Medicine; gamma-Aminobutyric Acid; Humans; Molecula	1990
Clinical relevance of measuring GABA concentrations in cerebrospinal fluid. Neurochemical research, 1990, Volume: 15, Issue:4 Topics: 4-Aminobutyrate Transaminase; Animals; Brain; gamma-Aminobutyric Acid; Humans; Hydrogen-Ion Concentr	1990
[Use of fenibut in psychiatry and neurology and its place among other psychotropic drugs (review of the literature)]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1989, Volume: 89, Issue:4 Topics: Adult; Child; Drug Evaluation; gamma-Aminobutyric Acid; Humans; Mental Disorders; Nervous System Dis	1989

Article	Year
Multimodal prevention of pain, nausea and vomiting after breast cancer surgery. Minerva anestesiologica, 2010, Volume: 76, Issue:10 Topics: Acetaminophen; Aged; Amines; Analgesics, Non-Narcotic; Anesthesia Recovery Period; Anesthesia, Intra	2010
Multimodal prevention of pain, nausea and vomiting after breast cancer surgery. Minerva anestesiologica, 2010, Volume: 76, Issue:10 Topics: Acetaminophen; Aged; Amines; Analgesics, Non-Narcotic; Anesthesia Recovery Period; Anesthesia, Intra	2010
Multimodal prevention of pain, nausea and vomiting after breast cancer surgery. Minerva anestesiologica, 2010, Volume: 76, Issue:10 Topics: Acetaminophen; Aged; Amines; Analgesics, Non-Narcotic; Anesthesia Recovery Period; Anesthesia, Intra	2010
Multimodal prevention of pain, nausea and vomiting after breast cancer surgery. Minerva anestesiologica, 2010, Volume: 76, Issue:10 Topics: Acetaminophen; Aged; Amines; Analgesics, Non-Narcotic; Anesthesia Recovery Period; Anesthesia, Intra	2010
Screening of the macromolecular component of CSF from various pathologies for its interference with GABAA receptor function. Italian journal of neurological sciences, 1995, Volume: 16, Issue:9 Topics: Adult; Aged; Animals; Cerebral Cortex; Cerebrospinal Fluid; Chlorine; Female; gamma-Aminobutyric Aci	1995

Article	Year
Vitamin D deficiency induces the excitation/inhibition brain imbalance and the proinflammatory shift. The international journal of biochemistry & cell biology, 2020, Volume: 119 Topics: Animals; Brain; Cholecalciferol; Cholesterol; Disease Models, Animal; gamma-Aminobutyric Acid; Gluta	2020
The γ-Protocadherins Regulate the Survival of GABAergic Interneurons during Developmental Cell Death. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020, 11-04, Volume: 40, Issue:45 Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cadherin Related Proteins; Cadherins; Cell Death; Ce	2020
The role of apitoxin in alleviating propionic acid-induced neurobehavioral impairments in rat pups: The expression pattern of Reelin gene. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 93 Topics: Animals; Bee Venoms; Brain; Cell Adhesion Molecules, Neuronal; Dopamine; Down-Regulation; Extracellu	2017
Notable advances 2017. Nature medicine, 2017, 12-07, Volume: 23, Issue:12 Topics: Aging; Biomedical Research; Cancer Vaccines; Cardiovascular Diseases; Diabetes Mellitus, Type 1; gam	2017
Baclofen and sleep apnoea syndrome: analysis of VigiBase, the WHO pharmacovigilance database. The European respiratory journal, 2018, Volume: 51, Issue:1 Topics: Administration, Oral; Adverse Drug Reaction Reporting Systems; Alcoholism; Apnea; Baclofen; Database	2018
Gamma-aminobutyric acid levels in cerebrospinal fluid in neuropaediatric disorders. Developmental medicine and child neurology, 2018, Volume: 60, Issue:8 Topics: Adolescent; Adult; Biomarkers; Child; Child, Preschool; Cohort Studies; Epilepsy; Female; gamma-Amin	2018
Direct conversion of mouse fibroblasts to GABAergic neurons with combined medium without the introduction of transcription factors or miRNAs. Cell cycle (Georgetown, Tex.), 2015, Aug-03, Volume: 14, Issue:15 Topics: Animals; Benzamides; Calcium Channels, L-Type; Cell- and Tissue-Based Therapy; Cells, Cultured; Cell	2015
Is there a role for anticonvulsants in the management of rheumatic pain? Joint bone spine, 2008, Volume: 75, Issue:6 Topics: Amines; Analgesics; Anticonvulsants; Cyclohexanecarboxylic Acids; Fibromyalgia; Gabapentin; gamma-Am	2008
Gabapentin therapy for pain and irritability in a neurologically impaired infant. Pharmacotherapy, 2009, Volume: 29, Issue:8 Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; Infant	2009
Preconditioning with subneurotoxic allyl nitrile: protection against allyl nitrile neurotoxicity. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2010, Volume: 48, Issue:2 Topics: Animals; Behavior, Animal; Brain; Cell Count; Dose-Response Relationship, Drug; Drug Administration	2010
Regulatory long non-coding RNAs and neuronal disorders. Physiology & behavior, 2010, Jun-01, Volume: 100, Issue:3 Topics: Animals; gamma-Aminobutyric Acid; Gene Expression Regulation, Developmental; Hippocampus; Humans; In	2010
Induction of the GABA cell phenotype: an in vitro model for studying neurodevelopmental disorders. PloS one, 2012, Volume: 7, Issue:3 Topics: Animals; Brain-Derived Neurotrophic Factor; Cell Line, Transformed; Chromatography, High Pressure Li	2012
Pregabalin attenuates docetaxel-induced neuropathy in rats. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 2012, Volume: 32, Issue:4 Topics: Animals; Docetaxel; gamma-Aminobutyric Acid; Ganglia, Spinal; Male; Nervous System Diseases; Pregaba	2012
[Potentially addictive drugs on reimbursable prescription for chronic severe pain]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2013, Jan-22, Volume: 133, Issue:2 Topics: Analgesics, Opioid; Chronic Pain; Drug Prescriptions; Drug Utilization; gamma-Aminobutyric Acid; Hum	2013
Salt and wounds: a new mechanism for neuropathic pain. Nature medicine, 2003, Volume: 9, Issue:9 Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Glycine; Humans; K Cl- Cotransporters; Ner	2003
[gamma-Aminobutyric acid-pyridoxine in the treatment of states of irritability and connected nervous disorders]. La Semana medica, 1962, Apr-16, Volume: 120 Topics: Amino Acids; gamma-Aminobutyric Acid; Irritable Mood; Mental Disorders; Nervous System Diseases; Neu	1962
BEHAVIOUR EXPERIMENTS IN RATS. PHARMACOLOGICAL ACTION OF GAMMA AMINOBUTYRIC ACID + VITAMIN B6. Life sciences (1962), 1964, Volume: 3 Topics: Aminobutyrates; Animals; Behavior, Animal; Brain Chemistry; gamma-Aminobutyric Acid; Learning; Nervo	1964
Ultrastructural organization of GABA-like immunoreactive profiles in the weaver substantia nigra. Journal of neurocytology, 2003, Volume: 32, Issue:3 Topics: Animals; Dendrites; Disease Models, Animal; Dopamine; Female; gamma-Aminobutyric Acid; Immunohistoch	2003
Efficient therapeutic gene expression in cultured rat hippocampal neurons mediated by human foamy virus vectors: a potential for the treatment of neurological diseases. Intervirology, 2005, Volume: 48, Issue:5 Topics: Animals; Cells, Cultured; gamma-Aminobutyric Acid; Genes, Reporter; Genetic Therapy; Genetic Vectors	2005
Gabapentin-induced neurologic toxicities. Pharmacotherapy, 2005, Volume: 25, Issue:12 Topics: Acute Kidney Injury; Aged; Amines; Analgesics; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminob	2005
Gabapentin successfully manages chronic unexplained irritability in children with severe neurologic impairment. Pediatrics, 2007, Volume: 119, Issue:2 Topics: Adolescent; Adult; Amines; Analgesics; Child; Child, Preschool; Chronic Disease; Cyclohexanecarboxyl	2007
Recombinant human foamy virus, a novel vector for neurological disorders gene therapy, drives production of GAD in cultured astrocytes. Molecular therapy : the journal of the American Society of Gene Therapy, 2007, Volume: 15, Issue:10 Topics: Animals; Astrocytes; Behavior, Animal; Cell Line; Cells, Cultured; Chromatography, High Pressure Liq	2007
gamma-Aminobutyric acid in CSF. Lancet (London, England), 1980, Jan-26, Volume: 1, Issue:8161 Topics: Evaluation Studies as Topic; Fluorometry; gamma-Aminobutyric Acid; Humans; Mental Disorders; Nervous	1980
Role of altered heme synthesis in lead neurotoxicity. Journal of occupational medicine. : official publication of the Industrial Medical Association, 1980, Volume: 22, Issue:10 Topics: Aminolevulinic Acid; gamma-Aminobutyric Acid; Heme; Humans; Lead Poisoning; Nervous System Diseases;	1980
Neurochemical transmission, neurotransmitters, and clinical correlations. Journal of neurosurgical nursing, 1982, Volume: 14, Issue:6 Topics: Acetylcholine; Dopamine; gamma-Aminobutyric Acid; Nervous System Diseases; Neurons; Neurotransmitter	1982
Development of central neurotransmitter-specified neuronal systems: implications for pediatric neuro-psychiatric disorders. Acta neurologica Scandinavica, 1984, Volume: 70, Issue:1 Topics: Afferent Pathways; Animals; Brain Damage, Chronic; Cats; Central Nervous System; Cerebral Cortex; Ch	1984
Free and conjugated GABA in human cerebrospinal fluid: effect of degenerative neurologic diseases and isoniazid. Brain research, 1984, Jul-30, Volume: 307, Issue:1-2 Topics: Adult; Age Factors; Aged; Cerebellar Ataxia; Dementia; Epilepsy; gamma-Aminobutyric Acid; Humans; Hu	1984
Levels of gamma-aminobutyric acid in cerebrospinal fluid in various neurologic disorders. Archives of neurology, 1980, Volume: 37, Issue:6 Topics: Brain Chemistry; Cerebellar Diseases; Creatine Kinase; Dementia; Diet; Encephalitis; Epilepsy; gamma	1980
GABA and neuropsychiatric disorders. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1980, Volume: 7, Issue:3 Topics: Animals; Basal Ganglia; Central Nervous System Diseases; Epilepsies, Myoclonic; Epilepsies, Partial;	1980
Roles of dopamine and GABA in neurotoxicity of organophosphorus cholinesterase inhibitors. Proceedings of the Western Pharmacology Society, 1984, Volume: 27 Topics: Animals; Cholinesterase Inhibitors; Dopamine; gamma-Aminobutyric Acid; Isoflurophate; Nervous System	1984
Monitoring of gamma-aminobutyric acid in human cerebrospinal fluid: downward revision of previous control values. Therapeutic drug monitoring, 1984, Volume: 6, Issue:2 Topics: Adult; Age Factors; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Nervous System Disea	1984
Cerebrospinal fluid GABA levels in various neurological and psychiatric diseases. Journal of neurology, neurosurgery, and psychiatry, 1982, Volume: 45, Issue:3 Topics: Adult; Female; gamma-Aminobutyric Acid; Humans; Male; Mental Disorders; Nervous System Diseases; Par	1982
Plasma and cerebrospinal fluid gamma-aminobutyric acid in neurological disorders. Journal of neurology, neurosurgery, and psychiatry, 1982, Volume: 45, Issue:10 Topics: Brain Neoplasms; Cerebral Infarction; Epilepsy; Female; gamma-Aminobutyric Acid; Humans; Male; Menin	1982
Norepinephrine and gamma-aminobutyric acid in amyotrophic lateral sclerosis. Neurology, 1980, Volume: 30, Issue:1 Topics: Adult; Amyotrophic Lateral Sclerosis; Female; gamma-Aminobutyric Acid; Humans; Male; Muscular Diseas	1980
Urinary excretion of gamma-hydroxybutyric acid in a patient with neurological abnormalities. The probability of a new inborn error of metabolism. Clinica chimica acta; international journal of clinical chemistry, 1981, Apr-09, Volume: 111, Issue:2-3 Topics: Fatty Acids, Nonesterified; gamma-Aminobutyric Acid; Gas Chromatography-Mass Spectrometry; Humans; H	1981
Clinical implications of enzyme-mediated alterations of gamma-aminobutyric acid content in human CSF. Archives of neurology, 1981, Volume: 38, Issue:8 Topics: Enzymes; Fluorometry; gamma-Aminobutyric Acid; Humans; Nervous System Diseases; Temperature	1981
Effect of freezing on gamma-aminobutyric acid levels in human cerebrospinal fluid. Journal of neurochemistry, 1981, Volume: 37, Issue:4 Topics: Adult; Freezing; gamma-Aminobutyric Acid; Humans; Middle Aged; Nervous System Diseases; Parkinson Di	1981
4-Hydroxybutyric aciduria: clinical findings and vigabatrin therapy. Journal of inherited metabolic disease, 1993, Volume: 16, Issue:3 Topics: Aldehyde Oxidoreductases; Anticonvulsants; Child; Female; gamma-Aminobutyric Acid; Gas Chromatograph	1993
[Effects of neurotropin in pain syndromes]. Biulleten' eksperimental'noi biologii i meditsiny, 1995, Volume: 119, Issue:1 Topics: Analgesics; Animals; Arthritis, Experimental; gamma-Aminobutyric Acid; Male; Nervous System Diseases	1995
4-Hydroxybutyric aciduria. Brain & development, 1994, Volume: 16 Suppl Topics: Adult; Anticonvulsants; Brain; Child; Child, Preschool; Dextromethorphan; Female; gamma-Aminobutyric	1994
Isocratic HPLC assay with electrochemical detection of free gamma-aminobutyric acid in cerebrospinal fluid. Clinical chemistry, 1993, Volume: 39, Issue:2 Topics: Adolescent; Adult; Aged; Chromatography, High Pressure Liquid; Electrochemistry; Female; gamma-Amino	1993
[Patterns in the change of the evoked skin autonomic potential in nervous system diseases]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 1997, Volume: 97, Issue:4 Topics: Adolescent; Adrenergic Agents; Adult; Autonomic Nervous System; Evoked Potentials; GABA Agents; gamm	1997
Gabapentin for treatment of neuropathic pain in a 12-year-old girl. The Clinical journal of pain, 1998, Volume: 14, Issue:4 Topics: Acetates; Amines; Child; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyric Acid; H	1998
Vigabatrin: new indication. An advance in infantile spasms. Prescrire international, 1998, Volume: 7, Issue:34 Topics: Anticonvulsants; Child; Child, Preschool; Clinical Trials as Topic; Drug Evaluation; France; gamma-A	1998
Antinociceptive effect of systemic gabapentin in mononeuropathic rats, depends on stimulus characteristics and level of test integration. Pain, 2000, Volume: 88, Issue:1 Topics: Acetates; Amines; Analgesics; Animals; Cold Temperature; Cyclohexanecarboxylic Acids; Gabapentin; ga	2000
Hyperfunction of dopaminergic and serotonergic neuronal systems in mice lacking the NMDA receptor epsilon1 subunit. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Jan-15, Volume: 21, Issue:2 Topics: Animals; Antipsychotic Agents; Biogenic Monoamines; Calcium; Corpus Striatum; Dizocilpine Maleate; D	2001
Gabapentin in painful HIV-related neuropathy: a report of 19 patients, preliminary observations. European journal of neurology, 2001, Volume: 8, Issue:1 Topics: Acetates; Adult; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Ami	2001
Cerebrospinal fluid gamma-aminobutyric acid in neurologic disease. Neurology, 1976, Volume: 26, Issue:8 Topics: Aminobutyrates; Cerebrovascular Disorders; Dementia; Epilepsy, Post-Traumatic; Epilepsy, Temporal Lo	1976
[Neurology in 1977]. La Revue du praticien, 1977, Jun-21, Volume: 27, Issue:35 Topics: Bromocriptine; Defense Mechanisms; Dopamine; Facial Paralysis; gamma-Aminobutyric Acid; Hemiplegia;	1977
Sodium-independent, high-affinity binding of [3H]gamma-aminobutyric acid in human neurological disorders. Advances in experimental medicine and biology, 1979, Volume: 123 Topics: Binding, Competitive; Brain; Cerebellar Cortex; gamma-Aminobutyric Acid; Humans; Huntington Disease;	1979
[Neurologic adverse manifestations and complications of ambulatory therapy with psychotropic drugs in the late stages]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1978, Volume: 78, Issue:2 Topics: Adult; Aged; Antidepressive Agents; Autonomic Nervous System; Basal Ganglia Diseases; Cognition Diso	1978
[Editorial: GABA and neurological disturbances]. Harefuah, 1975, Jul-01, Volume: 89, Issue:1 Topics: Aminobutyrates; gamma-Aminobutyric Acid; Humans; Nervous System Diseases	1975
[GABA and the central nervous system]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1975, Nov-30, Volume: 95, Issue:33 Topics: Aminobutyrates; gamma-Aminobutyric Acid; Humans; Nervous System Diseases	1975
Striatal dysfunction in Rolling mouse Nagoya: an electrophysiological study. Journal of the neurological sciences, 1992, Volume: 112, Issue:1-2 Topics: Animals; Corpus Striatum; Electric Stimulation; Electrophysiology; Evoked Potentials; Female; gamma-	1992
Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature, 1990, Sep-13, Volume: 347, Issue:6289 Topics: Animals; Animals, Newborn; Autoantibodies; Autoantigens; Autoimmunity; Brain; Diabetes Mellitus, Exp	1990
Neuroaxonal dystrophy in neuronal storage disorders: evidence for major GABAergic neuron involvement. Journal of the neurological sciences, 1991, Volume: 104, Issue:1 Topics: alpha-Mannosidosis; Animals; Axons; Cats; Cerebral Cortex; Choline O-Acetyltransferase; gamma-Aminob	1991
Determination of gamma-aminobutyric acid in human cerebrospinal fluid by isocratic high-performance liquid chromatography. Journal of chromatography, 1990, Aug-03, Volume: 529, Issue:2 Topics: Adult; Aged; Aging; Amino Acids; Amino Acids, Neutral; Chromatography, High Pressure Liquid; Female;	1990
Effects of DM-9384 in a model of amnesia based on animals with GABAergic neuronal dysfunctions. European journal of pharmacology, 1990, Mar-20, Volume: 178, Issue:2 Topics: Amnesia; Animals; Avoidance Learning; Bicuculline; Central Nervous System Agents; gamma-Aminobutyric	1990
4-aminobutyrate-2-ketoglutarate aminotransferase (GABA-T) in human hair follicle. Revista espanola de fisiologia, 1989, Volume: 45, Issue:4 Topics: 4-Aminobutyrate Transaminase; Adult; Aminocaproates; Aminooxyacetic Acid; Clinical Enzyme Tests; gam	1989
Simple aliphatic diamines: acute neurotoxicity. Research communications in chemical pathology and pharmacology, 1989, Volume: 64, Issue:3 Topics: Animals; Diamines; Electroencephalography; gamma-Aminobutyric Acid; Glutamates; Nervous System Disea	1989
Biochemical findings in symptomatic dystonias. Advances in neurology, 1988, Volume: 50 Topics: Acanthocytes; Adult; Brain; Dopamine; Dystonia; gamma-Aminobutyric Acid; Humans; Male; Nervous Syste	1988