gamma-aminobutyric acid has been researched along with Nerve Degeneration in 219 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The present study evaluated the distribution pattern of GABAergic interneurons, especially parvalbumin (PV)- and somatostatin (SS)-immunopositive neurons, and excitatory propagation pattern in the IC of rats 4-7 days and 2 months after pilocarpine-induced status epilepticus (4-7 d and 2 m post-SE rats, respectively)." | 7.76 | Pilocarpine-induced status epilepticus causes acute interneuron loss and hyper-excitatory propagation in rat insular cortex. ( Chen, S; Fujita, S; Kobayashi, M; Koshikawa, N, 2010) |
| " Pilocarpine-induced status epilepticus (SE) was chosen as a model to generate chronic epileptic animals." | 7.73 | Septal GABAergic neurons are selectively vulnerable to pilocarpine-induced status epilepticus and chronic spontaneous seizures. ( Banuelos, C; Castañeda, MT; Colom, LV; Garrido Sanabria, ER; Hernandez, S; Perez-Cordova, MG, 2006) |
| "Infusion of the K(+) channel blocker 4-aminopyridine in the hippocampus induces the release of glutamate, as well as seizures and neurodegeneration." | 7.70 | Seizures and neurodegeneration induced by 4-aminopyridine in rat hippocampus in vivo: role of glutamate- and GABA-mediated neurotransmission and of ion channels. ( Peña, F; Tapia, R, 2000) |
| "Epilepsy is a serious neurological disorder in human beings and the long-term pathological events remain largely obscure." | 5.35 | Time-course of neuronal death in the mouse pilocarpine model of chronic epilepsy using Fluoro-Jade C staining. ( Chen, LW; Huang, YG; Liu, YH; Wang, L, 2008) |
| "The initial diagnosis was of hydrocephalus and bilateral temporal cerebrospinal fluid collections." | 5.29 | Macrocephaly, dystonia, and bilateral temporal arachnoid cysts: glutaric aciduria type 1. ( Casas, C; Fernández, MA; Martínez-Lage, JF; Poza, M; Puche, A; Rodriguez Costa, T, 1994) |
| "The association of macrocephaly, dystonia, and bilateral temporal arachnoid cysts, shown either by computed tomography or magnetic resonance imaging, seems to be diagnostic of glutaric aciduria type 1." | 5.29 | Macrocephaly, dystonia, and bilateral temporal arachnoid cysts: glutaric aciduria type 1. ( Casas, C; Fernández, MA; Martínez-Lage, JF; Poza, M; Puche, A; Rodriguez Costa, T, 1994) |
| "Deficits in a variety of different neurochemical species are consistent with a loss of cortical gamma-aminobutyric acid (GABA)ergic interneurons in schizophrenia." | 4.81 | Neurochemical correlates of cortical GABAergic deficits in schizophrenia: selective losses of calcium binding protein immunoreactivity. ( Beasley, CL; Reynolds, GP; Zhang, ZJ, 2001) |
| " The present study evaluated the distribution pattern of GABAergic interneurons, especially parvalbumin (PV)- and somatostatin (SS)-immunopositive neurons, and excitatory propagation pattern in the IC of rats 4-7 days and 2 months after pilocarpine-induced status epilepticus (4-7 d and 2 m post-SE rats, respectively)." | 3.76 | Pilocarpine-induced status epilepticus causes acute interneuron loss and hyper-excitatory propagation in rat insular cortex. ( Chen, S; Fujita, S; Kobayashi, M; Koshikawa, N, 2010) |
| " Stereological techniques were used to estimate numbers of gephyrin-positive punctae in the dentate gyrus, which were reduced short-term (5 days after pilocarpine-induced status epilepticus) but later rebounded beyond controls in epileptic rats." | 3.76 | Initial loss but later excess of GABAergic synapses with dentate granule cells in a rat model of temporal lobe epilepsy. ( Buckmaster, PS; Phanwar, I; Thind, KK; Wen, X; Yamawaki, R; Zhang, G, 2010) |
| " Pilocarpine-induced status epilepticus (SE) was chosen as a model to generate chronic epileptic animals." | 3.73 | Septal GABAergic neurons are selectively vulnerable to pilocarpine-induced status epilepticus and chronic spontaneous seizures. ( Banuelos, C; Castañeda, MT; Colom, LV; Garrido Sanabria, ER; Hernandez, S; Perez-Cordova, MG, 2006) |
| "Infusion of the K(+) channel blocker 4-aminopyridine in the hippocampus induces the release of glutamate, as well as seizures and neurodegeneration." | 3.70 | Seizures and neurodegeneration induced by 4-aminopyridine in rat hippocampus in vivo: role of glutamate- and GABA-mediated neurotransmission and of ion channels. ( Peña, F; Tapia, R, 2000) |
| "Peripheral nerve injury affects motor functions." | 1.72 | Slow progression of sciatic nerve degeneration and regeneration after loose ligation through microglial activation and decreased KCC2 levels in the mouse spinal cord ventral horn. ( Kim, J; Kinjo, D; Kobayashi, S; Kosaka, Y; Matsuda, K; Okabe, A; Okura, N; Shimizu-Okabe, C; Takayama, C; Yafuso, T, 2022) |
| "Current pharmacological treatments for Parkinson's disease (PD) are focused on symptomatic relief, but not on disease modification, based on the strong belief that PD is caused by irreversible dopaminergic neuronal death." | 1.56 | Aberrant Tonic Inhibition of Dopaminergic Neuronal Activity Causes Motor Symptoms in Animal Models of Parkinson's Disease. ( Cho, IJ; Heo, JY; Huh, SH; Hwang, EM; Hwang, O; Hwang, YJ; Im, H; Jang, BK; Jang, DP; Jeon, SR; Jeong, JY; Jin, BK; Jo, S; Kim, HY; Kim, J; Kim, KI; Kim, S; Kim, Y; Kowall, NW; Kweon, GR; Lee, CJ; Lee, HJ; Lee, J; Lee, JA; Lee, MJ; Lee, SE; Nam, MH; Oh, SJ; Paek, SH; Park, HJ; Park, JH; Park, KD; Ryu, H; Shim, I; Shim, JE; Shin, H; Won, W; Woo, DH; Yoon, HH; Yoon, JH, 2020) |
| "Co-treatment with caffeine significantly decreased these upregulations at all time points investigated, while caffeine without phenobarbital resulted in increased expression of TNFα, IL-1β, and IL-18, but not IFNγ at 6 h." | 1.46 | Caffeine Protects Against Anticonvulsant-Induced Neurotoxicity in the Developing Rat Brain. ( Bendix, I; Bührer, C; Endesfelder, S; Schiller, C; Sifringer, M; Weichelt, U, 2017) |
| " These results raise the possibility that the phenobarbital-induced adverse effects could be reduced by a co-treatment with caffeine." | 1.46 | Caffeine Protects Against Anticonvulsant-Induced Neurotoxicity in the Developing Rat Brain. ( Bendix, I; Bührer, C; Endesfelder, S; Schiller, C; Sifringer, M; Weichelt, U, 2017) |
| "Robust allodynia was observed in all three ligation groups." | 1.42 | Ligation of mouse L4 and L5 spinal nerves produces robust allodynia without major motor function deficit. ( Baker, KB; Lanthorn, TH; Mason, S; Rajan, I; Savelieva, KV; Vogel, P; Ye, GL, 2015) |
| "The results of seizure scoring and histopathological findings in the hippocampus revealed a more pronounced response to the same administered TMT dose in juvenile mice, compared with that in adult mice." | 1.42 | Developmental and degenerative modulation of GABAergic transmission in the mouse hippocampus. ( Im, HI; Kang, S; Kim, J; Kim, JC; Kim, SH; Lee, S; Moon, C; Park, K; Shin, T; Son, Y; Takayama, C; Yang, M, 2015) |
| "Koumine treatment of diabetic rats decreased neuropathic pain behavior as early as after the first administration." | 1.40 | Anti-allodynic and neuroprotective effects of koumine, a Benth alkaloid, in a rat model of diabetic neuropathy. ( Huang, HH; Ling, Q; Liu, M; Wu, MX; Xu, Y; Yang, J; Yu, CX, 2014) |
| "Koumine was given at a dose range of 0." | 1.40 | Anti-allodynic and neuroprotective effects of koumine, a Benth alkaloid, in a rat model of diabetic neuropathy. ( Huang, HH; Ling, Q; Liu, M; Wu, MX; Xu, Y; Yang, J; Yu, CX, 2014) |
| "Diabetic rats developed mechanical hyperalgesia within 3 weeks after streptozocin injection and exhibited reduced SNCV and impaired myelin/axonal structure." | 1.40 | Anti-allodynic and neuroprotective effects of koumine, a Benth alkaloid, in a rat model of diabetic neuropathy. ( Huang, HH; Ling, Q; Liu, M; Wu, MX; Xu, Y; Yang, J; Yu, CX, 2014) |
| "Mice exhibited spontaneous neuropathic pain behaviors, which were most obvious after ischemia for 5 h." | 1.38 | Patterns of nerve injury and neuropathic pain in ischemic neuropathy after ligation-reperfusion of femoral artery in mice. ( Chiang, HY; Hsieh, JH; Hsieh, ST; Lee, JE; Wang, KC, 2012) |
| "Reversal of post-SCI neuropathic pain by tiagabine suggests that reduced GABAergic tone may contribute to hyperalgesia symptoms." | 1.36 | Loss of GABAergic interneurons in laminae I-III of the spinal cord dorsal horn contributes to reduced GABAergic tone and neuropathic pain after spinal cord injury. ( Marsh, AD; Marsh, DR; Meisner, JG, 2010) |
| "After global cerebral ischemia, delayed cell death is observed in the thalamic reticular nucleus but the mechanisms involved are not well described." | 1.35 | Endonuclease G expression in thalamic reticular nucleus after global cerebral ischemia. ( Diemer, NH; Nielsen, M; Zimmer, J, 2008) |
| "Epilepsy is a serious neurological disorder in human beings and the long-term pathological events remain largely obscure." | 1.35 | Time-course of neuronal death in the mouse pilocarpine model of chronic epilepsy using Fluoro-Jade C staining. ( Chen, LW; Huang, YG; Liu, YH; Wang, L, 2008) |
| " However, the dose-response curve significantly shifted toward lower concentration values in G93A motor neurons and the extent of desensitization also increased in these neurons." | 1.35 | GAB(A) receptors present higher affinity and modified subunit composition in spinal motor neurons from a genetic model of amyotrophic lateral sclerosis. ( Carunchio, I; Merlo, D; Mollinari, C; Pieri, M; Zona, C, 2008) |
| " For this purpose we conducted a dose-response study at concentrations of AMPA between 0." | 1.35 | Pattern of injury with a graded excitotoxic insult and ensuing chronic medial septal damage in the rat brain. ( Andrés, N; Batlle, M; Mahy, N; Malpesa, Y; Prats, A; Pugliese, M; Rodríguez, MJ, 2009) |
| " It is known that dopamine (DA) enhances this toxic effect." | 1.35 | Endogenous dopamine enhances the neurotoxicity of 3-nitropropionic acid in the striatum through the increase of mitochondrial respiratory inhibition and free radicals production. ( Cano, J; de Pablos, RM; Herrera, AJ; Machado, A; Navarro, A; Santiago, M; Tomás-Camardiel, M; Villarán, RF, 2008) |
| " A single dose of 1 mug of VEGF, chosen from a dose-response study, highly disrupted the BBB in the ventral mesencephalon in a time-dependent manner." | 1.34 | Blood-brain barrier disruption induces in vivo degeneration of nigral dopaminergic neurons. ( Cano, J; Machado, A; Rite, I; Venero, JL, 2007) |
| "Ten minutes of cerebral ischemia was produced by tightening the carotid ligatures bilaterally following hypotension." | 1.33 | Ischemic preconditioning ameliorates excitotoxicity by shifting glutamate/gamma-aminobutyric acid release and biosynthesis. ( Busto, R; Dave, KR; Lange-Asschenfeldt, C; Pérez-Pinzón, MA; Prado, R; Raval, AP; Saul, I, 2005) |
| "Infantile Neuronal Ceroid Lipofuscinosis (INCL) results from mutations in the palmitoyl protein thioesterase (PPT1, CLN1) gene and is characterized by dramatic death of cortical neurons." | 1.33 | Mice with Ppt1Deltaex4 mutation replicate the INCL phenotype and show an inflammation-associated loss of interneurons. ( Fabritius, AL; Gentile, M; Jalanko, A; Kopra, O; Manninen, T; Minye, H; Peltonen, L; Rapola, J; Salonen, T; Vesa, J; von Schantz, C, 2005) |
| "Epilepsy is closely related to an altered transmission of GABA, the major inhibitory transmitter in the brain." | 1.32 | Altered expression of GABAB receptors in the hippocampus after kainic-acid-induced seizures in rats. ( Bettler, B; Furtinger, S; Sperk, G, 2003) |
| " The toxic effect of gamma-vinyl-GABA was mimicked by a 24-h treatment with GABA (100 microM) and the GABA(A) receptor agonist, muscimol (10 microM), but not the GABA(B) receptor agonist, baclofen (10 microM)." | 1.31 | GABA(A)-mediated toxicity of hippocampal neurons in vitro. ( Lukasiuk, K; Pitkänen, A, 2000) |
| "Quisqualic acid was injected into the right nucleus basalis of rats." | 1.31 | Brain inflammatory reaction in an animal model of neuronal degeneration and its modulation by an anti-inflammatory drug: implication in Alzheimer's disease. ( Casamenti, F; Pepeu, G; Prosperi, C; Scali, C; Vannucchi, MG, 2000) |
| "Vigabatrin has been recommended as a treatment for some forms of childhood epilepsy; therefore, further studies are needed to assess the risks in children." | 1.30 | Low-dose vigabatrin (gamma-vinyl GABA)-induced damage in the immature rat brain. ( Del Bigio, MR; Seshia, SS; Sidhu, RS; Tuor, UI, 1997) |
| "Using this animal model of Huntington's disease, we investigated the ability of the insulin-like growth factor-I (IGF-I) amino-terminal tripeptide glycine-proline-glutamate (GPE) to protect striatal neurons from degeneration." | 1.30 | The IGF-I amino-terminal tripeptide glycine-proline-glutamate (GPE) is neuroprotective to striatum in the quinolinic acid lesion animal model of Huntington's disease. ( Alexi, T; Clark, RG; Faull, RL; Gluckman, PD; Hughes, PE; van Roon-Mom, WM; Williams, CE, 1999) |
| "Huntington's disease is an incurable genetic neurological disorder characterized by the relatively selective degeneration of the striatum." | 1.30 | The IGF-I amino-terminal tripeptide glycine-proline-glutamate (GPE) is neuroprotective to striatum in the quinolinic acid lesion animal model of Huntington's disease. ( Alexi, T; Clark, RG; Faull, RL; Gluckman, PD; Hughes, PE; van Roon-Mom, WM; Williams, CE, 1999) |
| "CGP 37849 was a weaker neuroprotectant than MK-801 (ED50 0." | 1.29 | A comparative analysis of the neuroprotective properties of competitive and uncompetitive N-methyl-D-aspartate receptor antagonists in vivo: implications for the process of excitotoxic degeneration and its therapy. ( Fagg, GE; Massieu, L; McVey, M; Thedinga, KH, 1993) |
| "The prion diseases are neurodegenerative conditions, transmissible by inoculation, and in some cases inherited as an autosomal dominant disorder." | 1.29 | Prion protein is necessary for normal synaptic function. ( Clarke, AR; Collinge, J; Jefferys, JG; Palmer, MS; Sidle, KC; Smith, CJ; Whittington, MA, 1994) |
| "The association of macrocephaly, dystonia, and bilateral temporal arachnoid cysts, shown either by computed tomography or magnetic resonance imaging, seems to be diagnostic of glutaric aciduria type 1." | 1.29 | Macrocephaly, dystonia, and bilateral temporal arachnoid cysts: glutaric aciduria type 1. ( Casas, C; Fernández, MA; Martínez-Lage, JF; Poza, M; Puche, A; Rodriguez Costa, T, 1994) |
| "The initial diagnosis was of hydrocephalus and bilateral temporal cerebrospinal fluid collections." | 1.29 | Macrocephaly, dystonia, and bilateral temporal arachnoid cysts: glutaric aciduria type 1. ( Casas, C; Fernández, MA; Martínez-Lage, JF; Poza, M; Puche, A; Rodriguez Costa, T, 1994) |
| " Dose-response showed that DL-(tetrazol-5-yl)glycine was about 100 and 500 times more potent than cis-methanoglutamate and NMDA, respectively." | 1.29 | The NMDA receptor agonist DL-(tetrazol-5-yl)glycine is a highly potent excitotoxin. ( Lunn, WH; McDonald, JW; Salhoff, CR; Schoepp, DD, 1994) |
| "Neurodegeneration in Alzheimer's disease is characterized by a selective loss of particular cell populations." | 1.29 | Cultured GABA-immunoreactive neurons are resistant to toxicity induced by beta-amyloid. ( Cotman, CW; Pike, CJ, 1993) |
| "Glycine change was primarily limited to a bilateral decrease in the dorsal part of the lateral vestibular nucleus." | 1.29 | Quantitative changes of amino acid distributions in the rat vestibular nuclear complex after unilateral vestibular ganglionectomy. ( Godfrey, DA; Godfrey, TG; Li, H; Rubin, AM, 1996) |
| "Kainic acid (KA)-induced convulsions are accompanied by histopathological changes that are most prominent in the temporal lobe structures." | 1.29 | Alpha 2-adrenoceptor agonist, dexmedetomidine, protects against kainic acid-induced convulsions and neuronal damage. ( Halonen, T; Kotti, T; Miettinen, R; Riekkinen, PJ; Toppinen, A; Tuunanen, J, 1995) |
| "Vigabatrin has been shown to protect against hippocampal neuronal cell death in experimental models of epilepsy." | 1.29 | Treatment with antiepileptic drugs: possible neuroprotective effects. ( Pitkänen, A, 1996) |
| "Taurine changes were similar to those of GABA in most regions." | 1.29 | Quantitative changes of amino acid distributions in the rat vestibular nuclear complex after unilateral vestibular ganglionectomy. ( Godfrey, DA; Godfrey, TG; Li, H; Rubin, AM, 1996) |
| "3." | 1.28 | Neuroprotective activity of chlormethiazole following transient forebrain ischaemia in the gerbil. ( Baldwin, HA; Cross, AJ; Green, AR; Jones, JA, 1991) |
| "Glycine levels were reduced by 9% in dorsolateral laminae VII and IX." | 1.27 | Amino acid levels in the guinea pig spinal gray matter after axotomy of primary sensory and descending tracts. ( Dymczyk, L; Potashner, SJ, 1986) |
| "Taurine uptake was reduced by a similar degree by both MSG and IAM treatment, 57% and 38% respectively." | 1.26 | Uptake, release, and binding of taurine in degenerated rat retinas. ( Pasantes-Morales, H; Salceda, R, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 38 (17.35) | 18.7374 |
| 1990's | 78 (35.62) | 18.2507 |
| 2000's | 69 (31.51) | 29.6817 |
| 2010's | 31 (14.16) | 24.3611 |
| 2020's | 3 (1.37) | 2.80 |
| Authors | Studies |
|---|---|
| Yafuso, T | 1 |
| Kosaka, Y | 1 |
| Shimizu-Okabe, C | 1 |
| Okura, N | 1 |
| Kobayashi, S | 1 |
| Kim, J | 6 |
| Matsuda, K | 1 |
| Kinjo, D | 1 |
| Okabe, A | 1 |
| Takayama, C | 3 |
| Cheng, A | 1 |
| Wang, J | 1 |
| Ghena, N | 1 |
| Zhao, Q | 1 |
| Perone, I | 1 |
| King, TM | 1 |
| Veech, RL | 1 |
| Gorospe, M | 1 |
| Wan, R | 1 |
| Mattson, MP | 1 |
| Heo, JY | 1 |
| Nam, MH | 1 |
| Yoon, HH | 1 |
| Hwang, YJ | 1 |
| Won, W | 1 |
| Woo, DH | 1 |
| Lee, JA | 1 |
| Park, HJ | 1 |
| Jo, S | 1 |
| Lee, MJ | 1 |
| Kim, S | 1 |
| Shim, JE | 1 |
| Jang, DP | 1 |
| Kim, KI | 1 |
| Huh, SH | 1 |
| Jeong, JY | 1 |
| Kowall, NW | 1 |
| Lee, J | 1 |
| Im, H | 1 |
| Park, JH | 1 |
| Jang, BK | 1 |
| Park, KD | 1 |
| Lee, HJ | 2 |
| Shin, H | 1 |
| Cho, IJ | 1 |
| Hwang, EM | 1 |
| Kim, Y | 1 |
| Kim, HY | 1 |
| Oh, SJ | 1 |
| Lee, SE | 1 |
| Paek, SH | 1 |
| Yoon, JH | 1 |
| Jin, BK | 1 |
| Kweon, GR | 1 |
| Shim, I | 1 |
| Hwang, O | 2 |
| Ryu, H | 1 |
| Jeon, SR | 1 |
| Lee, CJ | 1 |
| Endesfelder, S | 1 |
| Weichelt, U | 1 |
| Schiller, C | 1 |
| Sifringer, M | 1 |
| Bendix, I | 1 |
| Bührer, C | 1 |
| Khan, MSI | 1 |
| Nabeka, H | 2 |
| Islam, F | 1 |
| Shimokawa, T | 2 |
| Saito, S | 2 |
| Li, X | 1 |
| Kawabe, S | 1 |
| Hamada, F | 1 |
| Tachibana, T | 1 |
| Matsuda, S | 2 |
| Ambrad Giovannetti, E | 1 |
| Fuhrmann, M | 1 |
| Brown, AM | 1 |
| Arancillo, M | 1 |
| Lin, T | 1 |
| Catt, DR | 1 |
| Zhou, J | 2 |
| Lackey, EP | 1 |
| Stay, TL | 1 |
| Zuo, Z | 1 |
| White, JJ | 1 |
| Sillitoe, RV | 1 |
| Pintana, H | 1 |
| Lietzau, G | 1 |
| Augestad, IL | 1 |
| Chiazza, F | 1 |
| Nyström, T | 1 |
| Patrone, C | 1 |
| Darsalia, V | 1 |
| Vandevrede, L | 1 |
| Tavassoli, E | 1 |
| Luo, J | 2 |
| Qin, Z | 1 |
| Yue, L | 1 |
| Pepperberg, DR | 1 |
| Thatcher, GR | 1 |
| Valdeolivas, S | 1 |
| Pazos, MR | 1 |
| Bisogno, T | 1 |
| Piscitelli, F | 1 |
| Iannotti, FA | 1 |
| Allarà, M | 1 |
| Sagredo, O | 1 |
| Di Marzo, V | 1 |
| Fernández-Ruiz, J | 1 |
| Hendrickson, A | 1 |
| Warner, CE | 1 |
| Possin, D | 1 |
| Huang, J | 1 |
| Kwan, WC | 1 |
| Bourne, JA | 1 |
| Shilpa, J | 1 |
| Paulose, CS | 1 |
| Ye, GL | 1 |
| Savelieva, KV | 1 |
| Vogel, P | 1 |
| Baker, KB | 1 |
| Mason, S | 1 |
| Lanthorn, TH | 1 |
| Rajan, I | 1 |
| Ling, Q | 1 |
| Liu, M | 1 |
| Wu, MX | 1 |
| Xu, Y | 1 |
| Yang, J | 1 |
| Huang, HH | 1 |
| Yu, CX | 1 |
| Uematsu, K | 1 |
| Takechi, H | 1 |
| Yamamiya, K | 1 |
| Li, C | 1 |
| Doihara, T | 1 |
| Kobayashi, N | 1 |
| Son, Y | 1 |
| Lee, S | 1 |
| Kang, S | 1 |
| Park, K | 1 |
| Kim, SH | 1 |
| Kim, JC | 1 |
| Im, HI | 1 |
| Yang, M | 1 |
| Shin, T | 1 |
| Moon, C | 1 |
| Reda, HM | 1 |
| Zaitone, SA | 1 |
| Moustafa, YM | 1 |
| Bethmann, K | 1 |
| Fritschy, JM | 2 |
| Brandt, C | 1 |
| Löscher, W | 1 |
| Nielsen, M | 1 |
| Zimmer, J | 1 |
| Diemer, NH | 2 |
| Polgár, E | 1 |
| Todd, AJ | 1 |
| Wang, L | 1 |
| Liu, YH | 1 |
| Huang, YG | 1 |
| Chen, LW | 1 |
| Carunchio, I | 1 |
| Mollinari, C | 1 |
| Pieri, M | 1 |
| Merlo, D | 1 |
| Zona, C | 1 |
| Horn, AP | 1 |
| Frozza, RL | 1 |
| Grudzinski, PB | 1 |
| Gerhardt, D | 1 |
| Hoppe, JB | 1 |
| Bruno, AN | 1 |
| Chagastelles, P | 1 |
| Nardi, NB | 1 |
| Lenz, G | 1 |
| Salbego, C | 1 |
| Mulvey, JM | 1 |
| Renshaw, GM | 1 |
| Aruoma, OI | 1 |
| Jen, SS | 1 |
| Watts, HR | 1 |
| George, J | 1 |
| Gentleman, SM | 1 |
| Anderson, PJ | 1 |
| Jen, LS | 1 |
| Dugan, LL | 1 |
| Ali, SS | 1 |
| Shekhtman, G | 1 |
| Roberts, AJ | 1 |
| Lucero, J | 1 |
| Quick, KL | 1 |
| Behrens, MM | 1 |
| Rossi, S | 1 |
| De Chiara, V | 1 |
| Musella, A | 1 |
| Cozzolino, M | 1 |
| Bernardi, G | 3 |
| Maccarrone, M | 1 |
| Mercuri, NB | 2 |
| Carrì, MT | 1 |
| Centonze, D | 2 |
| Allen, KL | 1 |
| Waldvogel, HJ | 1 |
| Glass, M | 1 |
| Faull, RL | 2 |
| Fritsch, B | 1 |
| Qashu, F | 1 |
| Figueiredo, TH | 1 |
| Aroniadou-Anderjaska, V | 1 |
| Rogawski, MA | 1 |
| Braga, MF | 1 |
| Rodríguez, MJ | 1 |
| Prats, A | 1 |
| Malpesa, Y | 1 |
| Andrés, N | 1 |
| Pugliese, M | 1 |
| Batlle, M | 1 |
| Mahy, N | 2 |
| Kim, ST | 1 |
| Kim, EM | 1 |
| Choi, JH | 2 |
| Son, HJ | 1 |
| Ji, IJ | 1 |
| Joh, TH | 1 |
| Chung, SJ | 1 |
| Lee, CH | 1 |
| Hwang, IK | 2 |
| Yoo, KY | 2 |
| Han, TH | 1 |
| Park, OK | 1 |
| Lee, SY | 1 |
| Ryu, PD | 1 |
| Won, MH | 2 |
| Turner, CP | 1 |
| DeBenedetto, D | 1 |
| Ware, E | 1 |
| Stowe, R | 1 |
| Lee, A | 1 |
| Swanson, J | 1 |
| Walburg, C | 1 |
| Lambert, A | 1 |
| Lyle, M | 1 |
| Desai, P | 1 |
| Liu, C | 1 |
| Sperk, G | 3 |
| Drexel, M | 1 |
| Pirker, S | 1 |
| Chen, S | 2 |
| Fujita, S | 1 |
| Koshikawa, N | 1 |
| Kobayashi, M | 1 |
| Thind, KK | 1 |
| Yamawaki, R | 1 |
| Phanwar, I | 1 |
| Zhang, G | 1 |
| Wen, X | 1 |
| Buckmaster, PS | 1 |
| Meisner, JG | 1 |
| Marsh, AD | 1 |
| Marsh, DR | 1 |
| Zhang, H | 1 |
| Mei, X | 1 |
| Wang, W | 1 |
| Sun, X | 1 |
| Kim, YB | 1 |
| Ryu, JK | 1 |
| Lim, IJ | 1 |
| Park, D | 1 |
| Lee, MC | 1 |
| Kim, SU | 1 |
| García-Junco-Clemente, P | 1 |
| Cantero, G | 1 |
| Gómez-Sánchez, L | 1 |
| Linares-Clemente, P | 1 |
| Martínez-López, JA | 1 |
| Luján, R | 1 |
| Fernández-Chacón, R | 1 |
| Andrews-Zwilling, Y | 1 |
| Bien-Ly, N | 1 |
| Xu, Q | 1 |
| Li, G | 2 |
| Bernardo, A | 1 |
| Yoon, SY | 1 |
| Zwilling, D | 1 |
| Yan, TX | 1 |
| Chen, L | 1 |
| Huang, Y | 1 |
| Long, L | 1 |
| Xiao, B | 1 |
| Feng, L | 1 |
| Yi, F | 1 |
| Li, S | 1 |
| Mutasem, MA | 1 |
| Bi, F | 1 |
| Li, Y | 1 |
| Dinocourt, C | 1 |
| Aungst, S | 1 |
| Yang, K | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Longitudinal Early-onset Alzheimer's Disease Study Protocol[NCT03507257] | 700 participants (Anticipated) | Observational | 2018-04-30 | Recruiting | |||
| Phase I Study of Subthalamic GAD Gene Transfer in Medically Refractory Parkinson's Disease Patients[NCT00195143] | Phase 1 | 12 participants | Interventional | 2003-08-31 | Completed | ||
| Stress Response in Children Undergoing Cardiac Surgery: a Prospective Randomized Comparison Between Low Dose Fentanyl (LDF), Low Dose Fentanyl Plus Dexmedetomidine (LDF + Dex) and High Dose Fentanyl (HDF).[NCT00848393] | Phase 2 | 52 participants (Actual) | Interventional | 2008-11-30 | Completed | ||
| Anesthesia Exposure and Neurodevelopment in Infants and Children: Pediatric Anesthesia & NeuroDevelopment (PANDA) Study[NCT00881764] | 369 participants (Actual) | Observational | 2009-05-31 | Completed | |||
| A Comparison of Functional Magnetic Resonance Imaging (fMRI) Findings in Children With and Without a History of Early Exposure to General Anesthetics[NCT01229514] | 30 participants (Actual) | Observational | 2008-10-31 | Completed | |||
| The Role of the Coagulation Pathway at the Synapse in Prion Diseases[NCT02480725] | 50 participants (Anticipated) | Observational | 2015-06-30 | Not yet recruiting | |||
| A Randomized, Placebo-Controlled Pilot Study in Huntington's Disease (CIT-HD)[NCT00271596] | Phase 2 | 33 participants (Actual) | Interventional | 2005-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00848393)
Timeframe: Hospital admission to discharge from CTICU (average of 2-4 days)
| Intervention | Days (Median) |
|---|---|
| Fentanyl (High Dose) | 1 |
| Fentanyl (Low Dose) | 1 |
| Fentanyl (Low Dose) + Dexmedetomidine | 2 |
(NCT00848393)
Timeframe: Time of intubation to extubation (variable)
| Intervention | Hours (Median) |
|---|---|
| Fentanyl (High Dose) | 10.75 |
| Fentanyl (Low Dose) | 3.79 |
| Fentanyl (Low Dose) + Dexmedetomidine | 2.4 |
The ABAS-II is designed to evaluate whether an individual displays various functional skills necessary for daily living without the assistance of others. Thus, this instrument focuses on independent behaviors and measures what an individual actually does, in addition to measuring what he or she may be able to do. In addition, the ABAS-II focuses on behaviors an individual displays on his or her own, without assistance from others. The Parent/Primary Caregiver Form is a comprehensive, diagnostic measure of the adaptive skills that have primary relevance for the functioning of infants, toddlers, and preschoolers in the home and other settings, and can be completed by parents or other primary care providers. Each composite or domain score is determined by summing the appropriate scaled scores and then determining its equivalent composite or domain score by looking it up in a table located in the manual.The range for all scores is 50-150, with a higher score equaling a better outcome. (NCT00848393)
Timeframe: 1-4 yrs post-surgery
| Intervention | units on a scale (Mean) | |||
|---|---|---|---|---|
| ABAS-II General Adaptive Composite Score | ABAS-II Conceptual Adaptive Domain Score | ABAS-II Social Adaptive Domain Score | ABAS-II Practical Adaptive Domain Score | |
| Fentanyl (High Dose) | 96 | 99 | 102 | 93 |
| Fentanyl (Low Dose) | 102 | 106 | 106 | 96 |
| Fentanyl (Low Dose) + Dexmedetomidine | 100 | 99 | 105 | 95 |
N = 48 n = 16 (LDF); n = 17 (HDF); n = 15 (LDF + Dex) ACTH assayed by enzyme-linked immunosorbent assay (ELISA); Cytokine levels in plasma were measured using the Immulite automated chemiluminometer. Measured cytokines include interleukin (IL)-6, IL-8, IL-10, and tumor necrosis factor-α. (NCT00848393)
Timeframe: Blood draws to measure cytokines levels within one hour of draw: after induction; after sternotomy; after starting cardiopulmonary bypass; at the end of the procedure; and 24 hours after the procedure.
| Intervention | pg/mL (Mean) | ||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline ACTH (pg/mL) | Post-Sternotomy ACTH (pg/mL) | Post-Bypass ACTH (pg/mL) | End-Of-Surgery ACTH (pg/mL) | 24 hour Post-Surgery ACTH (pg/mL) | Baseline TNF-alpha (pg/mL) | Post-Sternotomy TNF-alpha (pg/mL) | Post-Bypass TNF-alpha (pg/mL) | End-Of-Surgery TNF-alpha (pg/mL) | 24 hour Post-Surgery TNF-alpha (pg/mL) | Baseline IL-6 (pg/mL) | Post-Sternotomy IL-6 (pg/mL) | Post-Bypass IL-6 (pg/mL) | End-Of-Surgery IL-6 (pg/mL) | 24 hour Post-Surgery IL-6 (pg/mL) | Baseline IL-8 (pg/mL) | Post-Sternotomy IL-8 (pg/mL) | Post-Bypass IL-8 (pg/mL) | End-Of-Surgery IL-8 (pg/mL) | 24 hour Post-Surgery IL-8 (pg/mL) | Baseline IL-10 (pg/mL) | Post-Sternotomy IL-10 (pg/mL) | Post-Bypass IL-10 (pg/mL) | End-Of-Surgery IL-10 (pg/mL) | 24 hour Post-Surgery IL-10 (pg/mL) | |
| Fentanyl (High Dose) | 116.9 | 44.5 | 57.2 | 66.4 | 12.7 | 15.70077 | 26.51846 | 24.30615 | 23.87077 | 15.79 | 6.637058824 | 5.402353 | 5.098824 | 20.48571 | 126.0813 | 17.12353 | 20.77647 | 9.770588 | 28.1 | 49.07143 | 10.82353 | 9.911765 | 9.488235 | 345.4412 | 10.80667 |
| Fentanyl (Low Dose) | 182.7 | 86.2 | 172.7 | 155.0 | 53.2 | 25.294 | 24.497 | 25.787 | 24.857 | 11.954 | 4.757142857 | 12.17333 | 5.509375 | 22.47333 | 117.975 | 10.44286 | 10.66667 | 10.13125 | 33.12667 | 47.25 | 9.9 | 9.9 | 9.9 | 325.55 | 14.80833 |
| Fentanyl (Low Dose) + Dexmedetomidine | 135.3 | 106.9 | 191.6 | 154.1 | 22.4 | 8.018182 | 17.88636 | 20.34364 | 23.06091 | 21.13909 | 5.542857143 | 6.241333 | 5.040667 | 20.79231 | 142.1571 | 10.25714 | 10.86667 | 9.673333 | 37.22143 | 24.27143 | 12.76429 | 14.10667 | 12.30667 | 569.2714 | 9.692857 |
The Stanford-Binet Intelligence Scale is now in its fifth edition (SB5) and was released in 2003. It is a cognitive ability and intelligence test that is used to diagnose developmental or intellectual deficiencies in young children. The test measures five weighted factors and consists of both verbal and nonverbal subtests. The five factors being tested are knowledge, quantitative reasoning, visual-spatial processing, working memory, and fluid reasoning. Raw scores for each subtest within the overall test are converted to scaled scores using a table within each test manual to look up equivalents. Scaled scores are then converted to standard scores (range=50-150). Higher scores suggest a higher level of functioning related to each category. (NCT00848393)
Timeframe: 1-4 yrs post-surgery
| Intervention | units on a scale (Mean) | ||||
|---|---|---|---|---|---|
| Quantative Reasoning Score | Knowledge Score | Visual Spatial Processing Score | Working Memory Score | Fluid Reasoning Score | |
| Fentanyl (High Dose) | 106 | 91 | 91 | 94 | 86 |
| Fentanyl (Low Dose) | 96 | 97 | 97 | 92 | 93 |
| Fentanyl (Low Dose) + Dexmedetomidine | 82 | 95 | 92 | 84 | 75 |
The Stanford-Binet test evaluates the overall IQ score from the assessment of cognitive ability. The test consists of 15 subtests, grouped into the four area scores. Six subtests are administered to all age levels. The subtests are: Vocabulary, Comprehension, Pattern Analysis, Quantitative, Bead Memory, and Memory for Sentences. Number of tests administered and test difficulty are based on the test taker's age and performance on subtest measuring word knowledge. The word knowledge subtest is given to all test takers and is the first subtest administered. A score of 100 is in the normal or average range. Higher scores suggest a higher level of functioning related to each category. (University of Cincinnati, 2003) Raw scores for each subtest within the overall test are converted to scaled scores using a table within each test manual to look up equivalents. Scaled scores are then converted to standard scores (range=50-150). (NCT00848393)
Timeframe: 1-4 yrs. post-surgery
| Intervention | IQ (Mean) | ||
|---|---|---|---|
| Nonverbal IQ composite score | Verbal IQ composite score | Full-scale IQ composite score | |
| Fentanyl (High Dose) | 92 | 93 | 93 |
| Fentanyl (Low Dose) | 98 | 91 | 94 |
| Fentanyl (Low Dose) + Dexmedetomidine | 89 | 80 | 83 |
Cortisol, epinephrine, and norepinephrine assayed by enzyme-linked immunosorbent assay (ELISA). (NCT00848393)
Timeframe: Blood draws to measure stress hormone levels within one hour of draw: after induction; after sternotomy; after starting cardiopulmonary bypass; at the end of the procedure; and 24 hours after the procedure.
| Intervention | ng/mL (Mean) | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline Norepinephrine | Post-Sternotomy Norepinephrine | Post-Bypass Norepinephrine | End-of-Surgery Norepinephrine | 24 hour Post-Surgery Norepinephrine | Baseline ephinephrine | Post-Sternotomy Epinephrine | Post-Bypass Epinephrine | End-of-Surgery Epinephrine | 24 hour Post-Surgery Epinephrine | Baseline Cortisol | Post-Sternotomy Cortisol | Post-Bypass Cortisol | End-of-Surgery Cortisol | 24 hour Post-Surgery Cortisol | |
| Fentanyl (High Dose) | 13.32618 | 16.2606 | 23.35796 | 11.22376 | 19.03031 | 2.7848 | 2.376012 | 18.176 | 14.65742 | 5.004787 | 334.7762 | 353.5396 | 279.0063 | 333.0644 | 237.5506 |
| Fentanyl (Low Dose) | 19.34153 | 17.08766 | 22.31064 | 10.74731 | 20.85433 | 6.439221 | 9.843591 | 21.9075 | 8.620669 | 3.537063 | 449.1974 | 363.5948 | 395.1298 | 463.3857 | 266.8754 |
| Fentanyl (Low Dose) + Dexmedetomidine | 19.45968 | 12.74458 | 19.73612 | 7.727055 | 26.67379 | 5.876335 | 10.89824 | 20.5294 | 8.083004 | 4.418208 | 352.4913 | 361.0074 | 354.8089 | 387.3673 | 265.7373 |
Full Scale Name: The Executive Composite Score (ECS). Definition: Subscales were averaged to compute this composite total score. The ECS is the weighted average of performance on 6 subtests of executive function, including (1) the Controlled Oral Word Association Test, (2) Symbol Digit Modalities test; (3) Stroop Color Word Test (Interference Trial), (4) Trail Making test (Part B), (5) Letter-Number Sequencing, and (6) Animal Naming. Construct Measured: Thinking tasks involving planning, working memory, attention, problem solving, verbal reasoning, inhibition, mental flexibility, and task switching. ECS Scale Range: The ECS score ranges from -5 to +5 on a standardized (Z) score scale, where lower scores indicate poorer performance on executive functioning tasks. Change Calculation Details: Compares change in executive functioning performance from visit 2 (week 0) to the weighted average of visits 5 (week 12) & 6 (week 15) for the citalopram versus placebo cohort. (NCT00271596)
Timeframe: after 15 weeks of treatment
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Citalopram | 0.005 |
| Placebo | 0.172 |
Full Scale Name: Hamilton Rating Scale for Depression (HAM-D). Definition: The Hamilton Rating Scale for Depression is a clinician-administered multiple item questionnaire used to provide an indication of depression. Construct Measured: Depression. HAM-D Score Range: Raw scores may range from 0 to 54, where higher scores indicate worsening mood. Change Calculation Details: Compares change in mood from screening (intake visit) to visit 6 (week 15) for the citalopram versus placebo cohort. (NCT00271596)
Timeframe: after 15 weeks of treatment
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Citalopram | -0.67 |
| Placebo | 1.23 |
Full Scale Name: Letter Number Sequencing (LNS) subtest from the Wechsler Adult Intelligence Scale (WAIS) third edition. Definition: LNS is a task that requires the reordering of an initially unordered set of letters and numbers. Construct Measured: Working memory. LNS Score Range: Raw scores may range from 0 to 21, where lower scores indicate poorer performance in working memory. Change Calculation Details: Compares change in working memory performance from visit 2 (week 0) to the weighted average of visits 5 (week 12) & 6 (week 15) for the citalopram versus placebo cohort. (NCT00271596)
Timeframe: after 15 weeks of treatment
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Citalopram | -0.113 |
| Placebo | 0.225 |
Semantic Fluency Score. Definition: The Semantic Fluency Score is the number of words a person can produce given a category, including naming (1) Animal names, (2) Fruit names, (3) Boy names, (4) Girl names, and (5) Vegetable names. Construct Measured: Working memory and verbal initiation. Scale Range: The Semantic Fluency Score ranges from -5 to +5 on a standardized (Z) score scale, where lower scores indicate poorer performance on working memory tasks. Change Calculation Details: Compares change in working memory performance from visit 2 (week 0) where patients named fruit names to the weighted average of visits 5 (week 12) & 6 (week 15) where patients named girl names and vegetable names respectively for the citalopram versus placebo cohort. (NCT00271596)
Timeframe: after 15 weeks of treatment
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Citalopram | 0.386 |
| Placebo | 0.664 |
"Full Scale Name: Stroop Interference subtest from The Stroop Color and Word Test. Definition: Participants are asked to name the ink color in which a word is printed when the word itself (which is irrelevant to the task) is the name of a different color rather than the same color. For example, participants may be asked to say red to the word blue printed in red ink. Constructs Measured: Selective attention, response inhibition, cognitive flexibility, and processing speed. Scale Range: The Stroop Interference score ranges from -5 to +5 on a standardized (Z) score scale, where lower scores indicate poorer performance. Change Calculation Details: Compares change in attention and processing speed performance from visit 2 (week 0) to the weighted average of visits 5 (week 12) and 6 (week 15) for the citalopram versus placebo cohort." (NCT00271596)
Timeframe: after 15 weeks of treatment
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Citalopram | -0.256 |
| Placebo | -0.046 |
Full Scale Name: Hamilton Rating Scale for Depression (HAM-D). Definition: The Hamilton Rating Scale for Depression is a clinician-administered multiple item questionnaire used to provide an indication of depression. Construct Measured: Depression. HAM-D Score Range: Raw scores may range from 0 to 54, where higher scores indicate worsening mood. Change Calculation Details: This analysis was restricted to a subgroup and, accordingly, does not reflect the total number of participants as reported in the Participant Flow. This analysis compares change in mood from screening (intake visit) to visit 6 (week 15) for the citalopram versus placebo cohort. (NCT00271596)
Timeframe: after 15 weeks of treatment
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Citalopram | -0.10 |
| Placebo | 1.50 |
Full Scale Name: The Symbol Digit Modalities Test (SDMT). Definition: The SDMT screens for organic cerebral dysfunction by having the examinee use a reference key to pair specific numbers with given geometric figures in 90 seconds. Construct Measured: Attention, processing speed, and working memory. SDMT Scale Range: Raw scores may range from 0 to 110, where lower scores indicate poorer performance. Change Calculation Details: Compares change in performance from visit 2 (week 0) to the weighted average of visits 5 (week 12) & 6 (week 15) for the citalopram versus placebo cohort. (NCT00271596)
Timeframe: after 15 weeks of treatment
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Citalopram | -0.227 |
| Placebo | -0.170 |
Full Scale Name: The Total Functional Capacity (TFC) subscale from the Unified Huntington's Disease Rating Scale (UHDRS). Definition: The TFC is a score that classifies five stages of Huntington's Disease and five levels of function in the domains of workplace, finances, domestic chores, activities of daily living and requirements for unskilled or skilled care. Construct Measured: Activities of Daily Living. Scale Range: The TFC score ranges from 0 to 13, where lower scores indicate poorer performance in activities of daily living. Change Calculation Details: Compares change in TFC performance from Baseline (week -4) to the weighted average of visits 4 (week 6) and 6 (week 15) for the citalopram versus placebo cohort. (NCT00271596)
Timeframe: after 15 weeks of treatment
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Citalopram | -0.54 |
| Placebo | -0.06 |
"Full Scale Name: Trail Making Test Part B (TMT-B). Definition: The TMT-B test requires participants to connect-the-dots of 25 consecutive targets on a sheet of paper where the subject alternates between numbers and letters, going in both numerical and alphabetical order. Constructs Measured: Attention, set shifting, and processing speed. Scale range: The TMT-B score ranges from -5 to +5 on a standardized (Z) score scale, where lower scores indicate poorer performance. Change Calculation Details: Compares change in attention and processing speed performance from visit 2 (week 0) to the weighted average of visits 5 (week 12) and 6 (week 15) for the citalopram versus placebo cohort." (NCT00271596)
Timeframe: after 15 weeks of treatment
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Citalopram | 0.087 |
| Placebo | 0.405 |
Full Scale Name: The Verbal Fluency Score (VFC). Definition: The VFC is the number of words a person can produce given a letter, including (1) Naming words that start with F, A, and S; (2) naming words that start with K, W, and R; (3) naming words that start with V, I, and P; (4) naming words that start with O, G, and B; (5) naming words that start with E, N, and T; and (6) naming words that start with J, C, and S. Construct Measured: Verbal initiation and flexibility. Scale Range: The Verbal Fluency Composite Score ranges from -5 to +5 on a standardized (Z) score scale, where lower scores indicate poorer performance. Change Calculation Details: Compares change in verbal initiation and flexibility from visit 2 (week 0) where patients named words starting with O, G, and B to the weighted average of visits 5 (week 12) and 6 (week 15) where patients named words starting with E, N, and T, and J, C, and S respectively for the citalopram versus placebo cohort. (NCT00271596)
Timeframe: after 15 weeks of treatment
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Citalopram | 0.140 |
| Placebo | 0.071 |
15 reviews available for gamma-aminobutyric acid and Nerve Degeneration
| Article | Year |
|---|---|
Unsupervised excitation: GABAergic dysfunctions in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Disease Models, Animal; GABAergic Neurons; | 2019 |
Neuronal plasticity in animal models and the epileptic human hippocampus.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; gamma-Aminobutyri | 2009 |
Blocking conversion of GABAergic inhibition as a potential mechanism of propofol-mediated brain protection following resuscitation.
Topics: Animals; Brain; Brain-Derived Neurotrophic Factor; Cardiopulmonary Resuscitation; gamma-Aminobutyric | 2009 |
Use of anesthetic agents in neonates and young children.
Topics: Anesthetics; Animals; Apoptosis; Child; Child, Preschool; gamma-Aminobutyric Acid; Humans; Infant; I | 2007 |
Use of anesthetic agents in neonates and young children.
Topics: Anesthetics; Animals; Apoptosis; Child; Child, Preschool; gamma-Aminobutyric Acid; Humans; Infant; I | 2007 |
Use of anesthetic agents in neonates and young children.
Topics: Anesthetics; Animals; Apoptosis; Child; Child, Preschool; gamma-Aminobutyric Acid; Humans; Infant; I | 2007 |
Use of anesthetic agents in neonates and young children.
Topics: Anesthetics; Animals; Apoptosis; Child; Child, Preschool; gamma-Aminobutyric Acid; Humans; Infant; I | 2007 |
Use of anesthetic agents in neonates and young children.
Topics: Anesthetics; Animals; Apoptosis; Child; Child, Preschool; gamma-Aminobutyric Acid; Humans; Infant; I | 2007 |
Use of anesthetic agents in neonates and young children.
Topics: Anesthetics; Animals; Apoptosis; Child; Child, Preschool; gamma-Aminobutyric Acid; Humans; Infant; I | 2007 |
Use of anesthetic agents in neonates and young children.
Topics: Anesthetics; Animals; Apoptosis; Child; Child, Preschool; gamma-Aminobutyric Acid; Humans; Infant; I | 2007 |
Use of anesthetic agents in neonates and young children.
Topics: Anesthetics; Animals; Apoptosis; Child; Child, Preschool; gamma-Aminobutyric Acid; Humans; Infant; I | 2007 |
Use of anesthetic agents in neonates and young children.
Topics: Anesthetics; Animals; Apoptosis; Child; Child, Preschool; gamma-Aminobutyric Acid; Humans; Infant; I | 2007 |
First one in, last one out: the role of gabaergic transmission in generation and degeneration.
Topics: Animals; Brain Mapping; Cytoskeleton; gamma-Aminobutyric Acid; Hippocampus; Humans; Nerve Degenerati | 1998 |
Chronic ethanol consumption: from neuroadaptation to neurodegeneration.
Topics: Acetylcholine; Adaptation, Physiological; Alcohol Amnestic Disorder; Alcohol Drinking; Alcohol-Relat | 1998 |
Narcolepsy: a key role for hypocretins (orexins)
Topics: Animals; Appetite; Arousal; Calcium Signaling; Carrier Proteins; Cataplexy; Chromosomes, Human, Pair | 1999 |
Neurochemical correlates of cortical GABAergic deficits in schizophrenia: selective losses of calcium binding protein immunoreactivity.
Topics: Biomarkers; Calcium-Binding Proteins; Cerebral Cortex; gamma-Aminobutyric Acid; Humans; Immunohistoc | 2001 |
Localization of transmitter candidates in the brain: the hippocampal formation as a model.
Topics: Acetylcholine; Acetylcholinesterase; Amino Acids; Animals; Brain; Choline O-Acetyltransferase; Dopam | 1977 |
Neurobiology and pharmacology of Huntington's disease.
Topics: Brain; Carnosine; Choline O-Acetyltransferase; Cholinergic Fibers; gamma-Aminobutyric Acid; Glutamat | 1977 |
[Demonstration of intrastriatal types of synapses and axon-collaterals by experimental isolation of fundus striati from all extrastriatal connections (author's transl)].
Topics: Animals; Axons; Brain Chemistry; Cats; Cerebral Ventricles; Dopamine; gamma-Aminobutyric Acid; Nerve | 1978 |
Regulatory role of astrocytes for neuronal biosynthesis and homeostasis of glutamate and GABA.
Topics: Alanine; Amino Acids; Animals; Astrocytes; Brain; Cell Communication; Epilepsy; gamma-Aminobutyric A | 1992 |
Local circuitry of the somatosensory thalamus in the processing of sensory information.
Topics: Animals; Cats; Dendrites; gamma-Aminobutyric Acid; Image Processing, Computer-Assisted; Microscopy, | 1991 |
Neuropeptide Y in cortex and striatum. Ultrastructural distribution and coexistence with classical neurotransmitters and neuropeptides.
Topics: Animals; Blood Vessels; Brain Mapping; Catecholamines; Cats; Cerebral Cortex; Corpus Striatum; gamma | 1990 |
A review of recent observations concerning the synaptic organization of the basilar pontine nuclei.
Topics: Animals; Basal Ganglia; Cerebellopontine Angle; gamma-Aminobutyric Acid; Immunohistochemistry; Micro | 1988 |
204 other studies available for gamma-aminobutyric acid and Nerve Degeneration
| Article | Year |
|---|---|
Slow progression of sciatic nerve degeneration and regeneration after loose ligation through microglial activation and decreased KCC2 levels in the mouse spinal cord ventral horn.
Topics: Animals; Choline O-Acetyltransferase; gamma-Aminobutyric Acid; Glycine; K Cl- Cotransporters; Mice; | 2022 |
SIRT3 Haploinsufficiency Aggravates Loss of GABAergic Interneurons and Neuronal Network Hyperexcitability in an Alzheimer's Disease Model.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cerebral Cortex; Diet, Ketogenic; Electr | 2020 |
Aberrant Tonic Inhibition of Dopaminergic Neuronal Activity Causes Motor Symptoms in Animal Models of Parkinson's Disease.
Topics: Aged; Aged, 80 and over; Animals; Astrocytes; Disease Models, Animal; Dopaminergic Neurons; Down-Reg | 2020 |
Caffeine Protects Against Anticonvulsant-Induced Neurotoxicity in the Developing Rat Brain.
Topics: Animals; Animals, Newborn; Anticonvulsants; Apoptosis; Brain; Caffeine; Cytokines; gamma-Aminobutyri | 2017 |
Early neonatal loss of inhibitory synaptic input to the spinal motor neurons confers spina bifida-like leg dysfunction in a chicken model.
Topics: Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Caspase 3; Chick Embryo; Chickens; Choline; | 2017 |
Molecular layer interneurons shape the spike activity of cerebellar Purkinje cells.
Topics: Action Potentials; Animals; Basic Helix-Loop-Helix Transcription Factors; Biomarkers; gamma-Aminobut | 2019 |
Obesity-induced type 2 diabetes impairs neurological recovery after stroke in correlation with decreased neurogenesis and persistent atrophy of parvalbumin-positive interneurons.
Topics: Age Factors; Animals; Atrophy; Brain; Diabetes Mellitus, Type 2; Disease Models, Animal; gamma-Amino | 2019 |
Novel analogues of chlormethiazole are neuroprotective in four cellular models of neurodegeneration by a mechanism with variable dependence on GABA(A) receptor potentiation.
Topics: Animals; Biological Availability; Brain; Calcium; Cell Hypoxia; Chlormethiazole; Chromatography, Hig | 2014 |
The inhibition of 2-arachidonoyl-glycerol (2-AG) biosynthesis, rather than enhancing striatal damage, protects striatal neurons from malonate-induced death: a potential role of cyclooxygenase-2-dependent metabolism of 2-AG.
Topics: Animals; Arachidonic Acids; Brain-Derived Neurotrophic Factor; Cell Death; Cyclooxygenase 2; Cytopro | 2013 |
Retrograde transneuronal degeneration in the retina and lateral geniculate nucleus of the V1-lesioned marmoset monkey.
Topics: Animals; Brain Injuries; Calbindin 1; Calbindin 2; Callithrix; gamma-Aminobutyric Acid; Geniculate B | 2015 |
GABA and 5-HT chitosan nanoparticles decrease striatal neuronal degeneration and motor deficits during liver injury.
Topics: Animals; Bromodeoxyuridine; Cell Differentiation; Cell Proliferation; Chitosan; Cytokines; Drug Deli | 2014 |
Ligation of mouse L4 and L5 spinal nerves produces robust allodynia without major motor function deficit.
Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Female; Gabapentin; gamma-Amin | 2015 |
Anti-allodynic and neuroprotective effects of koumine, a Benth alkaloid, in a rat model of diabetic neuropathy.
Topics: Amines; Animals; Blood Glucose; Body Weight; Cyclohexanecarboxylic Acids; Diabetes Mellitus, Experim | 2014 |
Prosaposin overexpression following kainic acid-induced neurotoxicity.
Topics: Animals; Cerebral Cortex; Choroid Plexus; GABAergic Neurons; gamma-Aminobutyric Acid; Gene Expressio | 2014 |
Developmental and degenerative modulation of GABAergic transmission in the mouse hippocampus.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Disease Models, Animal; gamma-Aminobut | 2015 |
Effect of levetiracetam versus gabapentin on peripheral neuropathy and sciatic degeneration in streptozotocin-diabetic mice: Influence on spinal microglia and astrocytes.
Topics: Amines; Animals; Astrocytes; Cyclohexanecarboxylic Acids; Diabetes Mellitus, Experimental; Diabetes | 2016 |
Antiepileptic drug resistant rats differ from drug responsive rats in GABA A receptor subunit expression in a model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Dentate Gyrus; Disease Models, Animal; Drug Resistance; Electric Stimulati | 2008 |
Endonuclease G expression in thalamic reticular nucleus after global cerebral ischemia.
Topics: Active Transport, Cell Nucleus; Animals; Apoptosis; Astrocytes; Biomarkers; Brain Infarction; Brain | 2008 |
Tactile allodynia can occur in the spared nerve injury model in the rat without selective loss of GABA or GABA(A) receptors from synapses in laminae I-II of the ipsilateral spinal dorsal horn.
Topics: Animals; Denervation; Disease Models, Animal; Functional Laterality; gamma-Aminobutyric Acid; Hypera | 2008 |
Time-course of neuronal death in the mouse pilocarpine model of chronic epilepsy using Fluoro-Jade C staining.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Brain; Cerebral Cortex; Chronic Disease; Convulsa | 2008 |
GAB(A) receptors present higher affinity and modified subunit composition in spinal motor neurons from a genetic model of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Cell Death; Cells, Cultured; Chloride Channels; Disease Mode | 2008 |
Conditioned medium from mesenchymal stem cells induces cell death in organotypic cultures of rat hippocampus and aggravates lesion in a model of oxygen and glucose deprivation.
Topics: Animals; Cell Death; Cells, Cultured; Culture Media, Conditioned; Excitatory Amino Acid Antagonists; | 2009 |
GABA is not elevated during neuroprotective neuronal depression in the hypoxic epaulette shark (Hemiscyllium ocellatum).
Topics: Acclimatization; Animals; Brain; Chromatography, High Pressure Liquid; Disease Models, Animal; gamma | 2009 |
Acute and chronic effects of intravitreally injected beta-amyloid on the neurotransmitter system in the retina.
Topics: Amyloid beta-Peptides; Animals; Choline O-Acetyltransferase; Cytochrome P-450 Enzyme System; Female; | 2009 |
IL-6 mediated degeneration of forebrain GABAergic interneurons and cognitive impairment in aged mice through activation of neuronal NADPH oxidase.
Topics: Aging; Animals; Cell Nucleus; Cognition; gamma-Aminobutyric Acid; Interleukin-6; Interneurons; Membr | 2009 |
Abnormal sensitivity of cannabinoid CB1 receptors in the striatum of mice with experimental amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Corpus Striatum; Disease Models, Animal; Dronabinol; Excitat | 2010 |
Cannabinoid (CB(1)), GABA(A) and GABA(B) receptor subunit changes in the globus pallidus in Huntington's disease.
Topics: Aged; Aged, 80 and over; Brain Mapping; Cannabinoid Receptor Modulators; Down-Regulation; Enkephalin | 2009 |
Pathological alterations in GABAergic interneurons and reduced tonic inhibition in the basolateral amygdala during epileptogenesis.
Topics: Amygdala; Animals; Convulsants; Down-Regulation; Epilepsy; Fluoresceins; gamma-Aminobutyric Acid; Gl | 2009 |
Pattern of injury with a graded excitotoxic insult and ensuing chronic medial septal damage in the rat brain.
Topics: Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Atroph | 2009 |
Matrix metalloproteinase-3 contributes to vulnerability of the nigral dopaminergic neurons.
Topics: Animals; Cell Count; Cells, Cultured; Corpus Striatum; Cytoprotection; Dendrites; Disease Models, An | 2010 |
Calcium binding proteins immunoreactivity in the rat basolateral amygdala following myocardial infarction.
Topics: Amygdala; Animals; Biomarkers; Brain Mapping; Calbindin 2; Calbindins; Calcium-Binding Proteins; Dep | 2010 |
Postnatal exposure to MK801 induces selective changes in GAD67 or parvalbumin.
Topics: Aging; Animals; Animals, Newborn; Cell Count; Cell Differentiation; Disease Models, Animal; Dizocilp | 2010 |
Pilocarpine-induced status epilepticus causes acute interneuron loss and hyper-excitatory propagation in rat insular cortex.
Topics: Animals; Biomarkers; Cell Count; Cerebral Cortex; Convulsants; Disease Models, Animal; Electric Stim | 2010 |
Initial loss but later excess of GABAergic synapses with dentate granule cells in a rat model of temporal lobe epilepsy.
Topics: Animals; Cell Count; Convulsants; Dendritic Spines; Dentate Gyrus; Disease Models, Animal; Epilepsy, | 2010 |
Loss of GABAergic interneurons in laminae I-III of the spinal cord dorsal horn contributes to reduced GABAergic tone and neuropathic pain after spinal cord injury.
Topics: Animals; Apoptosis; Caspase 3; Cell Count; Disease Models, Animal; Down-Regulation; GABA Agonists; G | 2010 |
Midkine, heparin-binding growth factor, blocks kainic acid-induced seizure and neuronal cell death in mouse hippocampus.
Topics: Animals; Anticonvulsants; Astrocytes; Biomarkers; Cell Death; Cytokines; Disease Models, Animal; Epi | 2010 |
Cysteine string protein-alpha prevents activity-dependent degeneration in GABAergic synapses.
Topics: Age Factors; Animals; Animals, Newborn; Astrocytes; Bicuculline; Cells, Cultured; Excitatory Amino A | 2010 |
Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice.
Topics: Age Factors; Analysis of Variance; Animals; Apolipoprotein E4; Cells, Cultured; Dentate Gyrus; Elect | 2010 |
Selective loss and axonal sprouting of GABAergic interneurons in the sclerotic hippocampus induced by LiCl-pilocarpine.
Topics: Animals; Axons; Disease Models, Animal; gamma-Aminobutyric Acid; Hippocampus; Interneurons; Lithium | 2011 |
Homeostatic increase in excitability in area CA1 after Schaffer collateral transection in vivo.
Topics: Action Potentials; Animals; CA1 Region, Hippocampal; Denervation; Fluoresceins; gamma-Aminobutyric A | 2011 |
Selective mGluR1 antagonist EMQMCM inhibits the kainate-induced excitotoxicity in primary neuronal cultures and in the rat hippocampus.
Topics: Animals; Apoptosis; Caspase 3; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Interactions; | 2012 |
GABA/glycine signaling during degeneration and regeneration of mouse hypoglossal nerves.
Topics: Animals; Carrier Proteins; Cholera Toxin; Choline O-Acetyltransferase; gamma-Aminobutyric Acid; Gene | 2012 |
Mutant TDP-43 and FUS cause age-dependent paralysis and neurodegeneration in C. elegans.
Topics: Aging; Animals; Animals, Genetically Modified; Caenorhabditis elegans; DNA-Binding Proteins; gamma-A | 2012 |
Patterns of nerve injury and neuropathic pain in ischemic neuropathy after ligation-reperfusion of femoral artery in mice.
Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Femoral Artery; Gaba | 2012 |
Unravelling the enigma of selective vulnerability in neurodegeneration: motor neurons resistant to degeneration in ALS show distinct gene expression characteristics and decreased susceptibility to excitotoxicity.
Topics: Aged; Amyotrophic Lateral Sclerosis; Female; gamma-Aminobutyric Acid; Gene Expression Regulation; Ge | 2013 |
Response of GABAergic cells in the deep mesencephalic nucleus to dopaminergic cell degeneration: an electrophysiological and in situ hybridization study.
Topics: Animals; Dopamine; Electrophysiology; gamma-Aminobutyric Acid; Glutamate Decarboxylase; In Situ Hybr | 2002 |
Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat.
Topics: 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic Acid; Animals; Biomarkers; Dopamine; Environm | 2002 |
Inhibition by naloxone stereoisomers of beta-amyloid peptide (1-42)-induced superoxide production in microglia and degeneration of cortical and mesencephalic neurons.
Topics: Amyloid beta-Peptides; Animals; Cells, Cultured; Cerebral Cortex; Dopamine; gamma-Aminobutyric Acid; | 2002 |
Subthalamic GAD gene therapy in a Parkinson's disease rat model.
Topics: Animals; Dependovirus; Disease Models, Animal; Dopamine; Electric Stimulation; Electrophysiology; ga | 2002 |
Influence of neurotrophins on the synaptogenesis of inner hair cells in the deaf Bronx waltzer (bv) mouse organ of Corti in culture.
Topics: Aging; Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor; Cell Count; Cell Differentiatio | 2002 |
Effects of dopaminergic cell degeneration on electrophysiological characteristics and GAD65/GAD67 expression in the substantia nigra: different action on GABA cell subpopulations.
Topics: Action Potentials; Animals; Dopamine; Electrophysiology; gamma-Aminobutyric Acid; Glutamate Decarbox | 2003 |
Altered expression of GABAB receptors in the hippocampus after kainic-acid-induced seizures in rats.
Topics: Animals; Dentate Gyrus; Down-Regulation; Epilepsy; Excitatory Amino Acid Agonists; gamma-Aminobutyri | 2003 |
Downregulation of the alpha5 subunit of the GABA(A) receptor in the pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Down-Regulation; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; | 2003 |
Ultrastructural organization of GABA-like immunoreactive profiles in the weaver substantia nigra.
Topics: Animals; Dendrites; Disease Models, Animal; Dopamine; Female; gamma-Aminobutyric Acid; Immunohistoch | 2003 |
Neuronal vulnerability following inhibition of mitochondrial complex II: a possible ionic mechanism for Huntington's disease.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Cell Respiration; Dose-Response Relationship, Drug; | 2004 |
Estrogen attenuates neuronal excitability in the insular cortex following middle cerebral artery occlusion.
Topics: Action Potentials; Animals; Cerebral Cortex; Disease Models, Animal; Down-Regulation; Estrogens; gam | 2004 |
The neurodegeneration sequence in prion diseases: evidence from functional, morphological and ultrastructural studies of the GABAergic system.
Topics: Animals; Cerebral Cortex; Cricetinae; gamma-Aminobutyric Acid; Male; Mesocricetus; Nerve Degeneratio | 2004 |
6-Hydroxydopamine induces dopaminergic cell degeneration via a caspase-9-mediated apoptotic pathway that is attenuated by caspase-9dn expression.
Topics: Animals; Animals, Newborn; Apoptosis; Caspase 3; Caspase 8; Caspase 9; Caspases; Cell Survival; Cell | 2004 |
Changes of pyridoxal kinase expression and activity in the gerbil hippocampus following transient forebrain ischemia.
Topics: Animals; Astrocytes; Disease Models, Animal; Down-Regulation; gamma-Aminobutyric Acid; Gerbillinae; | 2004 |
Mice with Ppt1Deltaex4 mutation replicate the INCL phenotype and show an inflammation-associated loss of interneurons.
Topics: Animals; Animals, Newborn; Blindness, Cortical; Cell Death; Cerebral Cortex; Disease Models, Animal; | 2005 |
Disease-related regressive alterations of forebrain cholinergic system in SOD1 mutant transgenic mice.
Topics: Acetylcholine; Amyotrophic Lateral Sclerosis; Animals; Basal Nucleus of Meynert; Brain Stem; Cerebra | 2005 |
Behavioral and neurochemical repercussions of hippocampal network activity blockade during the neonatal period.
Topics: Animals; Animals, Newborn; Behavior, Animal; Body Weight; Disease Models, Animal; Dopamine; Female; | 2005 |
Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease.
Topics: alpha-Synuclein; Animals; Astrocytes; Brain; Cells, Cultured; Dinoprostone; Dopamine; Embryo, Mammal | 2005 |
Ischemic preconditioning ameliorates excitotoxicity by shifting glutamate/gamma-aminobutyric acid release and biosynthesis.
Topics: Animals; Brain Ischemia; Cell Death; Disease Models, Animal; Extracellular Fluid; GABA Agonists; gam | 2005 |
Increased density of GABAA receptors in the superior temporal gyrus in schizophrenia.
Topics: Adaptation, Physiological; Adult; Binding, Competitive; GABA Agonists; gamma-Aminobutyric Acid; Hall | 2006 |
Salmonella lipopolysaccharide (LPS) mediated neurodegeneration in hippocampal slice cultures.
Topics: Animals; Animals, Newborn; CD11b Antigen; Cell Count; Dose-Response Relationship, Drug; gamma-Aminob | 2005 |
Clinical correlates of quantitative EEG alterations in alcoholic patients.
Topics: Adult; Age Factors; Aged; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders, Nervous System; Al | 2006 |
NAAG peptidase inhibitor increases dialysate NAAG and reduces glutamate, aspartate and GABA levels in the dorsal hippocampus following fluid percussion injury in the rat.
Topics: Animals; Aspartic Acid; Brain Injuries; Cytoprotection; Dipeptides; Disease Models, Animal; Down-Reg | 2006 |
Expression of glutamic acid decarboxylase and identification of GABAergic cells in the ischemic rat dentate gyrus.
Topics: Animals; Biomarkers; Brain Ischemia; Cell Count; Dentate Gyrus; Fluoresceins; gamma-Aminobutyric Aci | 2006 |
Septal GABAergic neurons are selectively vulnerable to pilocarpine-induced status epilepticus and chronic spontaneous seizures.
Topics: Analysis of Variance; Animals; Cell Survival; Disease Models, Animal; Fluoresceins; gamma-Aminobutyr | 2006 |
Neuroprotection by estradiol: a role of aromatase against spine synapse loss after blockade of GABA(A) receptors.
Topics: Animals; Aromatase; Cells, Cultured; Dendritic Spines; Down-Regulation; Enzyme Inhibitors; Epilepsy; | 2007 |
GABA(A)-receptor mRNA expression in the prefrontal and temporal cortex of ALS patients.
Topics: Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Biomarkers; Down-Regulation; gamma-Aminobuty | 2006 |
Altered neuronal responses and regulation of neurotrophic proteins in the medial septum following fimbria-fornix transection in CNTF- and leukaemia inhibitory factor-deficient mice.
Topics: Animals; Axotomy; Cell Count; Ciliary Neurotrophic Factor; Cytokines; Female; Fornix, Brain; gamma-A | 2006 |
Metabolic progression markers of neurodegeneration in the transgenic G93A-SOD1 mouse model of amyotrophic lateral sclerosis.
Topics: Age Factors; Amyotrophic Lateral Sclerosis; Analysis of Variance; Animals; Aspartic Acid; Disease Mo | 2007 |
Blood-brain barrier disruption induces in vivo degeneration of nigral dopaminergic neurons.
Topics: Animals; Apoptosis; Astrocytes; Blood-Brain Barrier; Dopamine; gamma-Aminobutyric Acid; Hippocampus; | 2007 |
EphB1 null mice exhibit neuronal loss in substantia nigra pars reticulata and spontaneous locomotor hyperactivity.
Topics: Animals; Basal Ganglia Diseases; beta-Galactosidase; Biomarkers; Cell Death; Cell Differentiation; C | 2007 |
The alpha7 nicotinic receptor agonist 4OH-GTS-21 protects axotomized septohippocampal cholinergic neurons in wild type but not amyloid-overexpressing transgenic mice.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Amyloid; Anabasine; Animals; Axotomy; Ce | 2007 |
Molecular and cellular characterization of the age-related neuroinflammatory processes occurring in normal rat hippocampus: potential relation with the loss of somatostatin GABAergic neurons.
Topics: Aging; Animals; Cell Count; Cell Death; Down-Regulation; Encephalitis; gamma-Aminobutyric Acid; Gene | 2007 |
Endogenous dopamine enhances the neurotoxicity of 3-nitropropionic acid in the striatum through the increase of mitochondrial respiratory inhibition and free radicals production.
Topics: alpha-Methyltyrosine; Animals; Apoptosis; Astrocytes; Cell Respiration; Corpus Striatum; Dopamine; D | 2008 |
Loss of Perineuronal Net in ME7 Prion Disease.
Topics: Animals; Disease Models, Animal; Disease Progression; Encephalitis; Extracellular Matrix; Female; ga | 2008 |
The role of the dorsomedial part of the prefrontal cortex serotonergic innervation in rat responses to the aversively conditioned context: behavioral, biochemical and immunocytochemical studies.
Topics: 5,7-Dihydroxytryptamine; Amygdala; Animals; Behavior, Animal; Brain; Chromatography, High Pressure L | 2008 |
GABAergic intrinsic interneurons in the red nucleus of the cat demonstrated with combined immunocytochemistry and anterograde degeneration methods.
Topics: Animals; Cats; gamma-Aminobutyric Acid; Histocytochemistry; Immunochemistry; Interneurons; Methods; | 1984 |
Substantia nigra cell death from kainic acid or folic acid injections into the pontine tegmentum.
Topics: Afferent Pathways; Animals; Cell Survival; Choline O-Acetyltransferase; Cholinergic Fibers; Dopamine | 1984 |
Axonal sprouts of the hypoglossal nerve implanted in the superior cervical ganglion of adult rats establish synaptic contacts under long-lasting GABA effect. An experimental degeneration study.
Topics: Animals; Autonomic Fibers, Preganglionic; Axons; Female; gamma-Aminobutyric Acid; Ganglia, Sympathet | 1983 |
Aspartate and not glutamate is the likely transmitter of the rat lateral olfactory tract fibres.
Topics: Animals; Aspartic Acid; Central Nervous System; Evoked Potentials; gamma-Aminobutyric Acid; Glutamat | 1981 |
Uptake, release, and binding of taurine in degenerated rat retinas.
Topics: Animals; gamma-Aminobutyric Acid; Nerve Degeneration; Rats; Rats, Inbred Strains; Receptors, Cell Su | 1982 |
Immunocytochemistry of glutamate decarboxylase in the deafferented habenula.
Topics: Afferent Pathways; Animals; Carboxy-Lyases; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hypoth | 1981 |
Interconnection of GABA-ergic neurons in rat extrapyramidal tract: analysis using intracerebral microinjection of kainic acid.
Topics: 4-Aminobutyrate Transaminase; Animals; Cerebral Cortex; Corpus Striatum; Electrolytes; Extrapyramida | 1980 |
Evidence for a GABAergic interface between cortical afferents and brainstem projection neurons in the rat central extended amygdala.
Topics: Amygdala; Animals; Brain Stem; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Ho | 1994 |
Corticorubral synaptic organization in Macaca fascicularis: a study utilizing degeneration, anterograde transport of WGA-HRP, and combined immuno-GABA-gold technique and computer-assisted reconstruction.
Topics: Animals; Cerebral Cortex; Dendrites; gamma-Aminobutyric Acid; Horseradish Peroxidase; Image Processi | 1994 |
Complex changes of GABAA and GABAB receptor binding in the spinal cord dorsal horn following peripheral inflammation or neurectomy.
Topics: Animals; Autoradiography; Binding, Competitive; Female; gamma-Aminobutyric Acid; Nerve Degeneration; | 1995 |
Evidence for a glutamatergic pathway from the guinea pig auditory cortex to the inferior colliculus.
Topics: Aspartic Acid; Auditory Cortex; Calcium; Carbon Radioisotopes; Electric Stimulation; Female; gamma-A | 1995 |
Differential effects of zinc on hyperpolarizing and depolarizing GABAA synaptic potentials in hippocampal slice cultures.
Topics: 4-Aminopyridine; Animals; Culture Techniques; Electrophysiology; Excitatory Amino Acid Antagonists; | 1995 |
Role of glucocorticoids in the cholinergic degeneration in rat hippocampus induced by ethylcholine aziridinium (AF64A).
Topics: Acetylcholine; Adrenalectomy; Animals; Aziridines; Cerebral Ventricles; Choline; Choline O-Acetyltra | 1993 |
A comparative analysis of the neuroprotective properties of competitive and uncompetitive N-methyl-D-aspartate receptor antagonists in vivo: implications for the process of excitotoxic degeneration and its therapy.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid | 1993 |
Accumulation of extracellular glutamate by inhibition of its uptake is not sufficient for inducing neuronal damage: an in vivo microdialysis study.
Topics: Animals; Cell Death; Choline; Choline O-Acetyltransferase; Corpus Striatum; Dicarboxylic Acids; Dizo | 1995 |
Elevated brain GABA correlates with systemic dysfunctions in paroxysmal chick.
Topics: Age Factors; Animals; Brain; Chickens; gamma-Aminobutyric Acid; Glucose; Mutation; Nerve Degeneratio | 1994 |
Prion protein is necessary for normal synaptic function.
Topics: Action Potentials; Animals; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Male; Mice; M | 1994 |
Macrocephaly, dystonia, and bilateral temporal arachnoid cysts: glutaric aciduria type 1.
Topics: Arachnoid Cysts; Brain; Brain Diseases; Carnitine; Dystonia; Female; gamma-Aminobutyric Acid; Glutar | 1994 |
The role of GABA-mediated inhibition in the rat ventral posterior medial thalamus. I. Assessment of receptive field changes following thalamic reticular nucleus lesions.
Topics: Animals; Brain Mapping; Dominance, Cerebral; Evoked Potentials, Somatosensory; Female; gamma-Aminobu | 1994 |
Brain-derived neurotrophic factor selectively rescues mesencephalic dopaminergic neurons from 2,4,5-trihydroxyphenylalanine-induced injury.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cell Survival; Cells, Cultured; Dihydroxyphenylalanine; | 1993 |
The NMDA receptor agonist DL-(tetrazol-5-yl)glycine is a highly potent excitotoxin.
Topics: Animals; Animals, Newborn; Brain; Choline O-Acetyltransferase; Female; gamma-Aminobutyric Acid; Glut | 1994 |
Comparison of intracranial infusions of colchicine and ibotenic acid as models of neurodegeneration in the basal forebrain.
Topics: Animals; Avoidance Learning; Basal Ganglia; Brain Chemistry; Catecholamines; Choline O-Acetyltransfe | 1994 |
Parvalbumin-immunoreactive dystrophic neurites and aberrant sprouts in the cerebral cortex of patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Cerebral Cortex; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged | 1993 |
Cultured GABA-immunoreactive neurons are resistant to toxicity induced by beta-amyloid.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Cells, Cultured; Drug Resistance; gamma-Aminob | 1993 |
Rapid decline of GABAA receptor subunit mRNA expression in hippocampus following transient cerebral ischemia in the gerbil.
Topics: Animals; Carotid Arteries; Chloride Channels; Constriction; gamma-Aminobutyric Acid; Gene Expression | 1993 |
Synaptic relationships between GABA-immunoreactive boutons and primary afferent terminals in the rat cuneate nucleus.
Topics: Afferent Pathways; Animals; gamma-Aminobutyric Acid; Horseradish Peroxidase; Male; Medulla Oblongata | 1993 |
3H-GABA administration during tail regeneration of lizards and autoradiographical localization.
Topics: Animals; Autoradiography; Axons; Female; gamma-Aminobutyric Acid; Immunohistochemistry; Lizards; Mal | 1993 |
Origin of chorea-ballism and multisystem degeneration: pathophysiological implications.
Topics: Animals; Basal Ganglia Diseases; Chorea; Dopamine; Dystonia; gamma-Aminobutyric Acid; Globus Pallidu | 1993 |
Expression of gamma-aminobutyric acid and calcium binding protein-parvalbumin by chick motoneurons.
Topics: Animals; Calcium-Binding Proteins; Chickens; gamma-Aminobutyric Acid; Immunohistochemistry; Motor Ne | 1993 |
Patterns of thalamocortical degeneration after ablation of somatosensory cortex in monkeys.
Topics: Animals; Electron Transport Complex IV; gamma-Aminobutyric Acid; Histocytochemistry; Immunohistochem | 1995 |
Survival of parvalbumin-immunoreactive neurons in the gerbil hippocampus following transient forebrain ischemia does not depend on HSP-70 protein induction.
Topics: Animals; Cell Survival; Dentate Gyrus; gamma-Aminobutyric Acid; Gerbillinae; Hippocampus; HSP70 Heat | 1995 |
Quantitative changes of amino acid distributions in the rat vestibular nuclear complex after unilateral vestibular ganglionectomy.
Topics: Amino Acids; Animals; Aspartic Acid; Behavior, Animal; gamma-Aminobutyric Acid; Ganglionectomy; Glut | 1996 |
Alpha 2-adrenoceptor agonist, dexmedetomidine, protects against kainic acid-induced convulsions and neuronal damage.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Anticonvulsants; Disease Models, A | 1995 |
Disturbances in the distribution of neurotransmitters in the rat retina after ischemia.
Topics: Animals; gamma-Aminobutyric Acid; Glutamic Acid; Immunohistochemistry; Intraocular Pressure; Ischemi | 1996 |
Treatment with antiepileptic drugs: possible neuroprotective effects.
Topics: Animals; Anticonvulsants; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Hippocampus; Humans; Ner | 1996 |
Neurochemical architecture of the normal and degenerating rat retina.
Topics: Amino Acids; Animals; Antibody Specificity; Arginine; Aspartic Acid; Autoradiography; gamma-Aminobut | 1996 |
Synaptic connections between identified neuron types in the antennal lobe glomeruli of the cockroach, Periplaneta americana: I. Uniglomerular projection neurons.
Topics: Animals; Axons; gamma-Aminobutyric Acid; Horseradish Peroxidase; Immunohistochemistry; Male; Microsc | 1997 |
Low-dose vigabatrin (gamma-vinyl GABA)-induced damage in the immature rat brain.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Apoptosis; Brain; Brain Damage, Chronic; Enz | 1997 |
Differential number of glycine- and GABA-immunopositive neurons and terminals in the deep cerebellar nuclei of normal and Purkinje cell degeneration mutant mice.
Topics: Animals; Cerebellar Nuclei; gamma-Aminobutyric Acid; Glycine; Immunohistochemistry; Mice; Mice, Neur | 1997 |
Structural alterations of the hippocampal formation of adrenalectomized rats: an unbiased stereological study.
Topics: Adrenalectomy; Animals; Astrocytes; Body Weight; Cell Count; Dentate Gyrus; gamma-Aminobutyric Acid; | 1997 |
Discussion of Bogerts' temporolimbic system theory of paranoid schizophrenia.
Topics: Adolescent; Adult; Animals; Brain Mapping; gamma-Aminobutyric Acid; Humans; Limbic System; Nerve Deg | 1997 |
Serotoninergic control of the activity and expression of glial GABA transporters in the rat cerebellum.
Topics: 5,7-Dihydroxytryptamine; Animals; Animals, Newborn; Base Sequence; Carrier Proteins; Cerebellum; DNA | 1998 |
Regionally specific induction of BDNF and truncated trkB.T1 receptors in the hippocampal formation after intraseptal injection of kainic acid.
Topics: Animals; Brain-Derived Neurotrophic Factor; Choline O-Acetyltransferase; Excitatory Amino Acid Agoni | 1998 |
Plastic changes in glycine and GABA release and uptake in adult brain stem auditory nuclei after unilateral middle ear ossicle removal and cochlear ablation.
Topics: Age Factors; Animals; Auditory Pathways; Carbon Radioisotopes; Cochlea; Cochlear Nerve; Cochlear Nuc | 1998 |
Callosal terminals in the rat prefrontal cortex: synaptic targets and association with GABA-immunoreactive structures.
Topics: Afferent Pathways; Animals; Corpus Callosum; gamma-Aminobutyric Acid; Male; Microscopy, Electron; Ne | 1998 |
Immunohistochemical evidence for dysregulation of the GABAergic system ipsilateral to photochemically induced cortical infarcts in rats.
Topics: Animals; Brain Ischemia; Cerebral Infarction; Dominance, Cerebral; gamma-Aminobutyric Acid; Gene Exp | 1998 |
A novel neurotransmitter system involved in the control of motor behavior by the basal ganglia.
Topics: Action Potentials; Analgesics; Animals; Basal Ganglia; Benzoxazines; Bicuculline; Cannabinoids; Cycl | 1998 |
Brain neurotransmitter deficits in mice transgenic for the Huntington's disease mutation.
Topics: Animals; Brain Chemistry; Disease Models, Animal; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; | 1999 |
Striatal, pallidal, and pars reticulata evoked inhibition of nigrostriatal dopaminergic neurons is mediated by GABA(A) receptors in vivo.
Topics: Afferent Pathways; Animals; Baclofen; Bicuculline; Corpus Striatum; Dopamine; Electric Stimulation; | 1999 |
Localization and source of gamma aminobutyric acid immunoreactivity in the isthmic nucleus of the frog Rana esculenta.
Topics: Animals; Antibodies; Brain Chemistry; Denervation; Female; gamma-Aminobutyric Acid; Interneurons; Ma | 1999 |
Electrophysiological and morphological evidence for a GABAergic nigrostriatal pathway.
Topics: Animals; Brain Mapping; Corpus Striatum; Dopamine; gamma-Aminobutyric Acid; Male; Nerve Degeneration | 1999 |
The ultrastructure of GABA-immunoreactive vestibular commissural neurons related to velocity storage in the monkey.
Topics: Animals; Axons; Behavior, Animal; gamma-Aminobutyric Acid; Immunohistochemistry; Macaca fascicularis | 1999 |
Ultrastructural features of non-commissural GABAergic neurons in the medial vestibular nucleus of the monkey.
Topics: Animals; Axons; Dendrites; gamma-Aminobutyric Acid; Macaca fascicularis; Macaca mulatta; Microscopy, | 1999 |
Toxicity of tunicamycin to cultured brain neurons: ultrastructure of the degenerating neurons.
Topics: Animals; Anti-Bacterial Agents; Cells, Cultured; Chick Embryo; Evoked Potentials; gamma-Aminobutyric | 1999 |
Nigral degeneration following striato-pallidal lesion in tissue type plasminogen activator deficient mice.
Topics: Animals; Cell Division; Female; gamma-Aminobutyric Acid; Globus Pallidus; Male; Mice; Mice, Inbred C | 1999 |
The IGF-I amino-terminal tripeptide glycine-proline-glutamate (GPE) is neuroprotective to striatum in the quinolinic acid lesion animal model of Huntington's disease.
Topics: Animals; Calbindin 2; Calbindins; Cell Count; Choline O-Acetyltransferase; Cholinergic Fibers; Corpu | 1999 |
Do GABAergic circuitries play a critical role in the regulation of seizure-induced neuronal damage and synaptic reorganization in the rat hippocampus?
Topics: Afferent Pathways; Animals; Brain Chemistry; Cell Survival; Denervation; Epilepsy, Temporal Lobe; Ex | 1999 |
Role for dopamine in malonate-induced damage in vivo in striatum and in vitro in mesencephalic cultures.
Topics: 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-; 3,4-Dihydrox | 2000 |
Bilateral blockade of NMDA receptors in anterior thalamus by dizocilpine (MK-801) injures pyramidal neurons in rat retrosplenial cortex.
Topics: Animals; Anterior Thalamic Nuclei; Baclofen; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; | 2000 |
GABA(A)-mediated toxicity of hippocampal neurons in vitro.
Topics: Animals; Anticonvulsants; Bicuculline; Cell Survival; Cells, Cultured; Epilepsy; Female; Fetus; GABA | 2000 |
Effects of a unilateral stereotaxic injection of Tinuvin 123 into the substantia nigra on the nigrostriatal dopaminergic pathway in the rat.
Topics: Animals; Astrocytes; Behavior, Animal; Calcium Channel Blockers; Decanoic Acids; Dopamine; Environme | 2000 |
Brain inflammatory reaction in an animal model of neuronal degeneration and its modulation by an anti-inflammatory drug: implication in Alzheimer's disease.
Topics: Acetylcholine; Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Choline O-Acetyl | 2000 |
The weaver mutation reverses the function of dopamine and GABA in mouse dopaminergic neurons.
Topics: Animals; Baclofen; Dopamine; G Protein-Coupled Inwardly-Rectifying Potassium Channels; gamma-Aminobu | 2000 |
Viral infection of developing GABAergic neurons in a model of hippocampal disinhibition.
Topics: Animals; Central Nervous System Viral Diseases; Dentate Gyrus; Disease Models, Animal; Epilepsy, Tem | 2000 |
Selective neuronal vulnerability during experimental scrapie infection: insights from an ultrastructural investigation.
Topics: Animals; Cricetinae; gamma-Aminobutyric Acid; Immunohistochemistry; Male; Mesocricetus; Microscopy, | 2000 |
Hypothermia inhibits ischemia-induced efflux of amino acids and neuronal damage in the hippocampus of aged rats.
Topics: Aging; Alanine; Amino Acids; Animals; Aspartic Acid; Brain Ischemia; Cerebrovascular Circulation; Ex | 2000 |
Deficits in striatal dopamine D(2) receptors and energy metabolism detected by in vivo microPET imaging in a rat model of Huntington's disease.
Topics: Animals; Autoradiography; Benzazepines; Cocaine; Corpus Striatum; Disease Models, Animal; Dopamine A | 2000 |
Seizures and neurodegeneration induced by 4-aminopyridine in rat hippocampus in vivo: role of glutamate- and GABA-mediated neurotransmission and of ion channels.
Topics: 4-Aminopyridine; Animals; Epilepsy; Excitatory Amino Acid Antagonists; GABA Agonists; GABA Antagonis | 2000 |
Intrapallidal dopamine restores motor deficits induced by 6-hydroxydopamine in the rat.
Topics: Animals; Apomorphine; Benzazepines; Dopamine; Dopamine Agonists; Dopamine Antagonists; gamma-Aminobu | 2001 |
Propofol and sodium thiopental protect against MK-801-induced neuronal necrosis in the posterior cingulate/retrosplenial cortex.
Topics: Anesthetics, Intravenous; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Inter | 2001 |
Changes in the GABA-ergic system induced by trimethyltin application in the rat.
Topics: Aggression; Animals; Cell Death; Enzyme Induction; gamma-Aminobutyric Acid; Gene Expression Regulati | 2001 |
Spontaneous recurrent seizures and neuropathology in the chronic phase of the pilocarpine and picrotoxin model epilepsy.
Topics: Acetylcholine; Action Potentials; Aggression; Animals; Behavior, Animal; Brain; Chronic Disease; Dis | 2002 |
Differential susceptibility to ageing of rat preganglionic neurones projecting to the major pelvic ganglion and of their afferent inputs.
Topics: Afferent Pathways; Aging; Animals; Dendrites; Disease Susceptibility; Efferent Pathways; gamma-Amino | 2002 |
Distribution of postsynaptic GABA(A) receptor aggregates in the deep cerebellar nuclei of normal and mutant mice.
Topics: Aging; Animals; Animals, Newborn; Carrier Proteins; Cell Differentiation; Cerebellar Nuclei; Dendrit | 2002 |
Evidence for glutamate as a neurotransmitter in the corticofugal fibres to the dorsal lateral geniculate body and the superior colliculus in rats.
Topics: Animals; Female; gamma-Aminobutyric Acid; Geniculate Bodies; Glutamates; Male; Nerve Degeneration; N | 1978 |
Long-term sequelae of striatal kainate lesion.
Topics: Acetylcholine; Animals; Choline; Choline O-Acetyltransferase; Corpus Striatum; Dopamine; gamma-Amino | 1978 |
Alteration in tyrosine hydroxylase, glutamic acid decarboxylase and choline acetyltransferase in basal ganglia following herpes simplex virus inoculation in rat neostriatum.
Topics: Acetylcholine; Animals; Basal Ganglia; Carboxy-Lyases; Cerebral Cortex; Choline O-Acetyltransferase; | 1979 |
An animal model for Huntington's disease.
Topics: Animals; Choline O-Acetyltransferase; Corpus Striatum; Disease Models, Animal; gamma-Aminobutyric Ac | 1979 |
Effect of chronic bulbectomy on the depth distribution of amino acid transmitter candidates in rat olfactory cortex.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; Denervation; gamma-Aminobutyric Acid; | 1979 |
Evidence for a GABAergic projection from the substantia nigra to the ventromedial thalamus and to the superior colliculus of the rat.
Topics: Animals; Choline O-Acetyltransferase; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Kainic Acid; | 1979 |
Characterization of the pigeon isthmo-tectal pathway by selective uptake and retrograde movement of radioactive compounds and by Golgi-like horseradish peroxidase labeling.
Topics: Acetylcholinesterase; Amino Acids; Animals; Axonal Transport; Choline; Columbidae; gamma-Aminobutyri | 1977 |
Inhibitors of GABA metabolism: implications for Huntington's disease.
Topics: 4-Aminobutyrate Transaminase; Alkynes; Aminocaproates; Aminocaproic Acid; Animals; Caudate Nucleus; | 1977 |
Evidence for a hippocampal-septal glutamatergic pathway in the rat.
Topics: Acetylcholine; Animals; gamma-Aminobutyric Acid; Glutamates; Hippocampus; Kainic Acid; Nerve Degener | 1979 |
In vitro behavior of granule cells from Staggerer and Weaver mutants of mice.
Topics: Animals; Cell Survival; Cerebellar Cortex; Culture Techniques; gamma-Aminobutyric Acid; Mice; Micros | 1977 |
Neurochemical and morphological consequences of axon terminal degeneration in cerebellar deep nuclei of mice with inherited Purkinje cell degeneration.
Topics: 4-Aminobutyrate Transaminase; Age Factors; Amino Acids; Animals; Axons; Brain Mapping; Cerebellar Co | 1979 |
Relative 'trophic' influences of excitatory and inhibitory innervation of locust skeletal muscle fibres.
Topics: Animals; gamma-Aminobutyric Acid; Glutamates; Grasshoppers; Membrane Potentials; Muscle Denervation; | 1979 |
Is there a selectivity of neuronal degeneration induced by intrastriatal injection of kainic acid?
Topics: Acetylcholinesterase; Animals; Brain Mapping; Corpus Striatum; Dopamine; Female; gamma-Aminobutyric | 1979 |
Origin and distribution of glutamate decarboxylase in the nucleus subthalamicus of the cat.
Topics: Afferent Pathways; Animals; Carboxy-Lyases; Cats; gamma-Aminobutyric Acid; Globus Pallidus; Glutamat | 1978 |
Release of endogenous glutamic acid, aspartic acid and GABA from cochlear nucleus slices.
Topics: Animals; Aspartic Acid; Calcium; Cochlear Nerve; Female; gamma-Aminobutyric Acid; Glutamates; Guinea | 1979 |
Tectal deafferentation in the frog: selective loss of L-glutamate and gamma-aminobutyrate.
Topics: Amino Acids; Aminobutyrates; Animals; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamates; | 1976 |
Fine structural synaptic organization of the corpus striatum and substantia nigra in rat and cat.
Topics: Animals; Autoradiography; Brain Mapping; Cats; Corpus Striatum; gamma-Aminobutyric Acid; Microscopy, | 1975 |
Reduction of GABA synthesis following lesions of inhibitory vestibulotrochlear pathway.
Topics: Aminobutyrates; Animals; Cats; gamma-Aminobutyric Acid; Mesencephalon; Nerve Degeneration; Neural Pa | 1975 |
On chorea: possible neuronal mechanisms.
Topics: Animals; Brain Mapping; Corpus Striatum; Dopamine; Enkephalins; gamma-Aminobutyric Acid; Humans; Hun | 1992 |
Local circuitry of GABAergic basket cells in the dentate gyrus.
Topics: Animals; Axons; Cerebral Cortex; Dendrites; Electric Stimulation; gamma-Aminobutyric Acid; Hippocamp | 1992 |
Synaptic and nonsynaptic determinants of excitability changes in aluminum-intoxicated rabbit CA1 pyramidal neurons studied in vitro.
Topics: Aluminum; Aluminum Chloride; Aluminum Compounds; Animals; Chlorides; Culture Techniques; Dose-Respon | 1992 |
Glutamate transmission is involved in the mechanisms of neuronal degeneration produced by intrahippocampal tetanus toxin in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; gamma-Aminobutyric Acid; Hippocampus; Mal | 1992 |
Intrahippocampal tetanus toxin produces generalized convulsions and neurodegeneration in rats: antagonism by NMDA receptor blockers.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Carbamazepine; Diazepam; Dizocilpine Maleate; | 1992 |
Widespread neuronal degeneration after ibotenic acid lesioning of cholinergic neurons in the nucleus basalis revealed by in situ hybridization.
Topics: Animals; Autoradiography; Choline O-Acetyltransferase; gamma-Aminobutyric Acid; Glutamate Decarboxyl | 1992 |
Enhancement of GABA neurotransmission after cerebral ischemia in the rat reduces loss of hippocampal CA1 pyramidal cells.
Topics: Animals; Arousal; Brain Ischemia; Cell Count; Cell Survival; Diazepam; Dose-Response Relationship, D | 1991 |
A case of adult onset pure pallidal degeneration. II. Analysis of neurotransmitter markers, with special reference to the termination of pallidothalamic tract in human brain.
Topics: Adult; Aged; Basal Ganglia Diseases; Biomarkers; Brain Chemistry; Choline O-Acetyltransferase; Femal | 1991 |
Direct and indirect retinal input into degenerated dorsal lateral geniculate nucleus after striate cortical removal in monkey: implications for residual vision.
Topics: Animals; Dendrites; gamma-Aminobutyric Acid; Geniculate Bodies; Horseradish Peroxidase; Immunohistoc | 1991 |
Neuroprotective activity of chlormethiazole following transient forebrain ischaemia in the gerbil.
Topics: Animals; Body Temperature; Chlormethiazole; Drug Synergism; gamma-Aminobutyric Acid; Gerbillinae; Hi | 1991 |
Effects of bilateral clamping of carotid arteries on hippocampal kindling in rats.
Topics: Animals; Brain Ischemia; Brain Mapping; Female; Frontal Lobe; gamma-Aminobutyric Acid; Hippocampus; | 1991 |
L-dopa stimulates the release of [3H]gamma-aminobutyric acid in the basal ganglia of 6-hydroxydopamine lesioned rats.
Topics: Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Basal Ganglia; Benzazepines; Brain Chemistry; | 1991 |
Masking effect of NMDA receptor antagonists on the formation of long-term potentiation (LTP) in superior colliculus slices from the guinea pig.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Denervation; Dibenzocycloheptenes; Dipeptides; | 1990 |
Dual effect of glycine on NMDA-induced neurotoxicity in rat cortical cultures.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cells, Cultured; Cerebral Cortex; Drug Synergism; gamma-Aminob | 1990 |
Catecholaminergic, GABAergic, and hippocamposeptal innervation of GABAergic "somatospiny" neurons in the rat lateral septal area.
Topics: Animals; Axons; Catecholamines; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hippocampus; Immun | 1990 |
Neuroplasticity following traumatic brain injury: a study of GABAergic terminal loss and recovery in the cat dorsal lateral vestibular nucleus.
Topics: Animals; Brain; Brain Injuries; Cats; Female; gamma-Aminobutyric Acid; Immunoenzyme Techniques; Immu | 1991 |
Hypertrophy of inferior olivary neurons: a degenerative, regenerative or plasticity phenomenon.
Topics: Animals; Cats; Cerebellum; gamma-Aminobutyric Acid; Hypertrophy; Nerve Degeneration; Nerve Regenerat | 1990 |
Reorganization of GABAergic synapses in the viper optic tectum following retinal deafferentation.
Topics: Afferent Pathways; Animals; Female; gamma-Aminobutyric Acid; Immunohistochemistry; Male; Nerve Degen | 1990 |
gamma-Aminobutyric acid system in developing and degenerating mouse retina.
Topics: Animals; Animals, Newborn; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Mice; Mice, Inbred C3H; | 1990 |
Chronic infusion of GABA and saline into the nucleus basalis magnocellularis of rats: II. Cognitive impairments.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Avoidance Learning; Basal Ganglia; Brain Mapping; Cogn | 1990 |
Synaptic connections of dopamine-immunoreactive neurons in the antennal lobes of Periplaneta americana. Colocalization with GABA-like immunoreactivity.
Topics: Animals; Cockroaches; Dopamine; gamma-Aminobutyric Acid; Immunohistochemistry; Interneurons; Male; M | 1990 |
Hippocampal fibers make synaptic contacts with glutamate decarboxylase-immunoreactive neurons in the rat nucleus accumbens.
Topics: Animals; Female; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hippocampus; Immunohistochemistry | 1990 |
CGS-19755 and MK-801 selectively prevent rat striatal cholinergic and gabaergic neuronal degeneration induced by N-methyl-D-aspartate and ibotenate in vivo.
Topics: Animals; Aspartic Acid; Choline O-Acetyltransferase; Cholinergic Fibers; Corpus Striatum; Dibenzocyc | 1989 |
Opposite effects of monosodium glutamate on the dopaminergic and GABAergic innervations of the median eminence and the intermediate lobe in the mouse.
Topics: Animals; Animals, Newborn; Axons; Brain Chemistry; Dopamine; gamma-Aminobutyric Acid; Glutamates; Hy | 1985 |
"Epileptic" brain damage is replicated qualitatively in the rat hippocampus by central injection of glutamate or aspartate but not by GABA or acetylcholine.
Topics: Acetylcholine; Animals; Aspartic Acid; Brain; Disease Models, Animal; Epilepsy; gamma-Aminobutyric A | 1985 |
Amino acid levels in the guinea pig spinal gray matter after axotomy of primary sensory and descending tracts.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Axons; gamma-Aminobutyric Acid; Glutamates; Glutamic A | 1986 |
Changes in the content of glutamate and GABA in the cerebellar vermis and hemispheres of the Purkinje cell degeneration (pcd) mutant.
Topics: Alanine; Animals; Cerebellum; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Mice; Mic | 1988 |
Ultrastructural and neurochemical effects of the presumed cholinergic toxin AF64A in the rat interpeduncular nucleus.
Topics: Animals; Aziridines; Azirines; Brain Chemistry; Choline; Cholinergic Fibers; gamma-Aminobutyric Acid | 1986 |
Delayed transneuronal death of substantia nigra neurons prevented by gamma-aminobutyric acid agonist.
Topics: Animals; Cell Survival; gamma-Aminobutyric Acid; Ibotenic Acid; Male; Muscimol; Nerve Degeneration; | 1987 |
Decreased uptake and release of D-aspartate in the guinea pig spinal cord after partial cordotomy.
Topics: Animals; Aspartic Acid; Biological Transport; gamma-Aminobutyric Acid; Guinea Pigs; Nerve Degenerati | 1985 |
Acute responses of rat retina after optic nerve ligation: a biochemical and histochemical study.
Topics: Animals; Autoradiography; Dopamine; gamma-Aminobutyric Acid; Leucine; Ligation; Nerve Degeneration; | 1985 |