gamma-aminobutyric acid has been researched along with Muscle Rigidity in 21 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
Muscle Rigidity: Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected muscle is passively stretched, the degree of resistance remains constant regardless of the rate at which the muscle is stretched. This feature helps to distinguish rigidity from MUSCLE SPASTICITY. (From Adams et al., Principles of Neurology, 6th ed, p73)
| Excerpt | Relevance | Reference |
|---|---|---|
| "GABA levels were unaltered by Parkinson's disease, clinical phenotype, or medication." | 1.56 | GABAergic changes in the thalamocortical circuit in Parkinson's disease. ( Cools, R; den Ouden, HEM; Dirkx, MFM; Helmich, RC; Scheenen, TWJ; Toni, I; van Asten, JJA; van Nuland, AJM; Zach, H, 2020) |
| "Parkinson's disease is characterized by bradykinesia, rigidity, and tremor." | 1.56 | GABAergic changes in the thalamocortical circuit in Parkinson's disease. ( Cools, R; den Ouden, HEM; Dirkx, MFM; Helmich, RC; Scheenen, TWJ; Toni, I; van Asten, JJA; van Nuland, AJM; Zach, H, 2020) |
| " In addition the optimal time frame for cell grafting after ischemia and the optimal dosing of grafted cells were also studied." | 1.34 | Functional recovery in rats with ischemic paraplegia after spinal grafting of human spinal stem cells. ( Cizkova, D; Hazel, T; Hefferan, MP; Johe, K; Kakinohana, O; Kucharova, K; Marsala, M; Marsala, S, 2007) |
| "Transient spinal cord ischemia in humans can lead to the development of permanent paraplegia with prominent spasticity and rigidity." | 1.34 | Functional recovery in rats with ischemic paraplegia after spinal grafting of human spinal stem cells. ( Cizkova, D; Hazel, T; Hefferan, MP; Johe, K; Kakinohana, O; Kucharova, K; Marsala, M; Marsala, S, 2007) |
| "Spinal cord ischemia was induced for 10 min using aortic occlusion and systemic hypotension." | 1.34 | Functional recovery in rats with ischemic paraplegia after spinal grafting of human spinal stem cells. ( Cizkova, D; Hazel, T; Hefferan, MP; Johe, K; Kakinohana, O; Kucharova, K; Marsala, M; Marsala, S, 2007) |
| "We report the successful management of anesthesia in a patient with stiff-person syndrome (SPS) undergoing a thymectomy using a volatile anesthetic combined with epidural anesthesia." | 1.34 | Considerations for general anesthesia combined with epidural anesthesia in a patient with stiff-person syndrome. ( Hara, K; Horishita, T; Sata, T; Yamamoto, K, 2007) |
| "Transient spinal cord ischemia may lead to a progressive degeneration of spinal interneurons and subsequently to increased hind limb motor tone." | 1.33 | Development of GABA-sensitive spasticity and rigidity in rats after transient spinal cord ischemia: a qualitative and quantitative electrophysiological and histopathological study. ( Galik, J; Hefferan, MP; Kakinohana, M; Kakinohana, O; Marsala, J; Marsala, M; Nakamura, S; Tomori, Z; Yaksh, TL, 2006) |
| "We also characterized changes in the Huntington's disease patients according to pathological grade, since this may be a confounding factor." | 1.29 | Neurochemical substrates of rigidity and chorea in Huntington's disease. ( Beal, MF; Storey, E, 1993) |
| "Huntington's disease is a progressive degenerative neurological disorder which produces a characteristic movement disorder termed chorea." | 1.29 | Neurochemical substrates of rigidity and chorea in Huntington's disease. ( Beal, MF; Storey, E, 1993) |
| "The loss of this action would cause muscular rigidity and motor asymmetry." | 1.29 | Appearance of EMG activity and motor asymmetry after unilateral lesions of the dopaminergic innervation to the subthalamic nucleus in the rat. ( Aceves, J; Flores, G; Rosales, MG; Sierra, A; Valencia, J, 1993) |
| "To study MPTP-induced muscular rigidity, we try to detect the changes of both dopamine (DA) and GABA within rat striatums by immunohistochemical means." | 1.28 | Immunohistochemical detection of GABA in rat striatum by intraperitoneal injection of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine). ( Kawana, E; Yamamoto, C, 1991) |
| "Stiff-man syndrome is a rare disorder of the central nervous system consisting of progressive, fluctuating muscle rigidity with painful spasms." | 1.27 | Autoantibodies to glutamic acid decarboxylase in a patient with stiff-man syndrome, epilepsy, and type I diabetes mellitus. ( Comi, GC; De Camilli, P; Denis-Donini, S; Folli, F; Pozza, G; Solimena, M; Vicari, AM, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (33.33) | 18.7374 |
| 1990's | 6 (28.57) | 18.2507 |
| 2000's | 5 (23.81) | 29.6817 |
| 2010's | 2 (9.52) | 24.3611 |
| 2020's | 1 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| van Nuland, AJM | 1 |
| den Ouden, HEM | 1 |
| Zach, H | 1 |
| Dirkx, MFM | 1 |
| van Asten, JJA | 1 |
| Scheenen, TWJ | 1 |
| Toni, I | 1 |
| Cools, R | 1 |
| Helmich, RC | 1 |
| Dayalu, P | 1 |
| Teener, JW | 1 |
| Ali, F | 1 |
| Rowley, M | 1 |
| Jayakrishnan, B | 1 |
| Teuber, S | 1 |
| Gershwin, ME | 1 |
| Mackay, IR | 1 |
| Gazulla Abío, J | 2 |
| Benavente Aguilar, I | 2 |
| Capablo Liesa, JL | 2 |
| Kakinohana, O | 2 |
| Hefferan, MP | 2 |
| Nakamura, S | 1 |
| Kakinohana, M | 1 |
| Galik, J | 1 |
| Tomori, Z | 1 |
| Marsala, J | 1 |
| Yaksh, TL | 1 |
| Marsala, M | 2 |
| Cizkova, D | 1 |
| Kucharova, K | 1 |
| Marsala, S | 1 |
| Johe, K | 1 |
| Hazel, T | 1 |
| Yamamoto, K | 1 |
| Hara, K | 1 |
| Horishita, T | 1 |
| Sata, T | 1 |
| Turski, L | 4 |
| Havemann, U | 2 |
| Kuschinsky, K | 2 |
| Storey, E | 1 |
| Beal, MF | 1 |
| Berthier, M | 1 |
| Oriot, D | 1 |
| Bonneau, D | 1 |
| Jaeken, J | 1 |
| Flores, G | 1 |
| Valencia, J | 1 |
| Rosales, MG | 1 |
| Sierra, A | 1 |
| Aceves, J | 1 |
| Tijssen, MA | 1 |
| Schoemaker, HC | 1 |
| Edelbroek, PJ | 1 |
| Roos, RA | 1 |
| Cohen, AF | 1 |
| van Dijk, JG | 1 |
| Yamamoto, C | 1 |
| Kawana, E | 1 |
| Solimena, M | 2 |
| Folli, F | 2 |
| Aparisi, R | 1 |
| Pozza, G | 2 |
| De Camilli, P | 2 |
| Schwarz, M | 3 |
| Ikonomidou, C | 1 |
| Klockgether, T | 2 |
| Ellenbroek, B | 3 |
| Sontag, KH | 2 |
| Cools, A | 1 |
| Denis-Donini, S | 1 |
| Comi, GC | 1 |
| Vicari, AM | 1 |
| Gol'dblat, IuV | 1 |
| Lapin, IP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Efficacy of High-Dose Intravenous Immunoglobulin Therapy in Patients With Stiff-Man Syndrome: A Double-Blind, Placebo-Controlled Trial[NCT00001550] | Phase 1 | 20 participants | Interventional | 1996-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for gamma-aminobutyric acid and Muscle Rigidity
| Article | Year |
|---|---|
Stiff Person syndrome and other anti-GAD-associated neurologic disorders.
Topics: Autoantibodies; Central Nervous System; Female; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hu | 2012 |
Stiff-person syndrome (SPS) and anti-GAD-related CNS degenerations: protean additions to the autoimmune central neuropathies.
Topics: Autoantibodies; Central Nervous System; Diabetes Mellitus, Type 1; Epilepsy; GABAergic Neurons; gamm | 2011 |
1 trial available for gamma-aminobutyric acid and Muscle Rigidity
| Article | Year |
|---|---|
The effects of clonazepam and vigabatrin in hyperekplexia.
Topics: Acoustic Stimulation; Adult; Anticonvulsants; Clonazepam; Cross-Over Studies; Double-Blind Method; E | 1997 |
18 other studies available for gamma-aminobutyric acid and Muscle Rigidity
| Article | Year |
|---|---|
GABAergic changes in the thalamocortical circuit in Parkinson's disease.
Topics: Aged; Creatine; Dopamine Agents; Female; gamma-Aminobutyric Acid; Humans; Magnetic Resonance Spectro | 2020 |
[Progressive encephalomyelitis with rigidity responsive to gabapentin: a pharmacological update].
Topics: Amines; Antiparkinson Agents; Clonidine; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Dr | 2004 |
Development of GABA-sensitive spasticity and rigidity in rats after transient spinal cord ischemia: a qualitative and quantitative electrophysiological and histopathological study.
Topics: Acetyltransferases; Analysis of Variance; Animals; Baclofen; Dose-Response Relationship, Radiation; | 2006 |
Functional recovery in rats with ischemic paraplegia after spinal grafting of human spinal stem cells.
Topics: Adult; Animals; Astrocytes; Cell Proliferation; Cell Survival; Cells, Cultured; Evoked Potentials, M | 2007 |
Considerations for general anesthesia combined with epidural anesthesia in a patient with stiff-person syndrome.
Topics: Aged; Anesthesia, Epidural; Anesthesia, General; gamma-Aminobutyric Acid; Humans; Male; Muscle Rigid | 2007 |
Evidence for functional interactions of morphine in substantia nigra and striatum in relation to muscular rigidity in rats.
Topics: Animals; Corpus Striatum; Electromyography; gamma-Aminobutyric Acid; Male; Morphine; Muscle Rigidity | 1982 |
GABAergic mechanisms in mediating muscular rigidity, catalepsy and postural asymmetry in rats: differences between dorsal and ventral striatum.
Topics: Animals; Catalepsy; Corpus Striatum; gamma-Aminobutyric Acid; Humans; Male; Muscimol; Muscle Rigidit | 1984 |
Neurochemical substrates of rigidity and chorea in Huntington's disease.
Topics: Adolescent; Adult; Aged; Basal Ganglia; Child; Enkephalin, Methionine; Female; gamma-Aminobutyric Ac | 1993 |
Does a mutation of the glycine receptor modify GABA metabolism in startle disease?
Topics: gamma-Aminobutyric Acid; Humans; Infant; Muscle Rigidity; Point Mutation; Receptors, Glycine; Reflex | 1995 |
Appearance of EMG activity and motor asymmetry after unilateral lesions of the dopaminergic innervation to the subthalamic nucleus in the rat.
Topics: Animals; Bicuculline; Dopamine; Electromyography; gamma-Aminobutyric Acid; Male; Methamphetamine; Mo | 1993 |
[Progressive encephalomyelitis with rigidity. Clinical and electrophysiological aspects].
Topics: Acetates; Aged; Amines; Antiparkinson Agents; Cyclohexanecarboxylic Acids; Electrophysiology; Enceph | 2001 |
Immunohistochemical detection of GABA in rat striatum by intraperitoneal injection of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine).
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Dopamine; gamma-Aminobutyric Acid; Immunoenzy | 1991 |
Autoantibodies to GABA-ergic neurons and pancreatic beta cells in stiff-man syndrome.
Topics: Autoantibodies; Autoantigens; Autoimmune Diseases; Brain; Central Nervous System Diseases; Cerebrosp | 1990 |
The role of striatal cholinergic mechanisms for the development of limb rigidity: an electromyographic study in rats.
Topics: Animals; Bethanechol; Bethanechol Compounds; Brain Mapping; Cholinergic Fibers; Corpus Striatum; Ele | 1986 |
The importance of the striato-nigro-collicular pathway in the expression of haloperidol-induced tonic electromyographic activity.
Topics: Animals; Brain Mapping; Corpus Striatum; Electromyography; gamma-Aminobutyric Acid; Haloperidol; Mal | 1985 |
Distinct sites of functional interaction between dopamine, acetylcholine and gamma-aminobutyrate within the neostriatum: an electromyographic study in rats.
Topics: Acetylcholine; Animals; Corpus Striatum; Dopamine; Electromyography; gamma-Aminobutyric Acid; Male; | 1986 |
Autoantibodies to glutamic acid decarboxylase in a patient with stiff-man syndrome, epilepsy, and type I diabetes mellitus.
Topics: Autoantibodies; Autoimmune Diseases; Brain; Diabetes Mellitus, Type 1; Epilepsy; Female; gamma-Amino | 1988 |
[Phenibut potentiation of the therapeutic action of antiparkinson agents].
Topics: Adult; Aged; Antiparkinson Agents; Basal Ganglia Diseases; Drug Therapy, Combination; Follow-Up Stud | 1986 |