gamma-aminobutyric acid has been researched along with Lesch-Nyhan Syndrome in 6 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
Lesch-Nyhan Syndrome: An inherited disorder transmitted as a sex-linked trait and caused by a deficiency of an enzyme of purine metabolism; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE. Affected individuals are normal in the first year of life and then develop psychomotor retardation, extrapyramidal movement disorders, progressive spasticity, and seizures. Self-destructive behaviors such as biting of fingers and lips are seen frequently. Intellectual impairment may also occur but is typically not severe. Elevation of uric acid in the serum leads to the development of renal calculi and gouty arthritis. (Menkes, Textbook of Child Neurology, 5th ed, pp127)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Different brain regions were removed post mortem from three patients with the Lesch-Nyhan syndrome and were examined for alterations in hypoxanthine-guanine phosphoribosyl transferase (HGPRT), adenine phosphoribosyl transferase, and biochemical indexes of norepinephrine, dopamine, serotonin, gamma-aminobutyric acid (GABA), and acetylcholine neuron function, as compared with age-matched controls." | 3.66 | Biochemical evidence of dysfunction of brain neurotransmitters in the Lesch-Nyhan syndrome. ( Davidson, L; Farley, I; Fox, IH; Goldstein, M; Hornykiewicz, O; Kelley, WN; Lloyd, KG; Shannak, K; Shibuya, M, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (66.67) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lloyd, KG | 1 |
| Hornykiewicz, O | 2 |
| Davidson, L | 1 |
| Shannak, K | 1 |
| Farley, I | 1 |
| Goldstein, M | 1 |
| Shibuya, M | 1 |
| Kelley, WN | 1 |
| Fox, IH | 2 |
| McManaman, J | 1 |
| Tam, DA | 1 |
| Gedye, A | 1 |
| Harkness, RA | 1 |
| Kish, SJ | 1 |
| Kapur, BM | 1 |
| Lloyd, K | 1 |
| Baumeister, AA | 1 |
| Frye, GD | 1 |
1 review available for gamma-aminobutyric acid and Lesch-Nyhan Syndrome
| Article | Year |
|---|---|
The biochemical basis of the behavioral disorder in the Lesch-Nyhan syndrome.
Topics: Adenine Nucleotides; Animals; Central Nervous System; Child; Child, Preschool; Clonidine; Corpus Str | 1985 |
5 other studies available for gamma-aminobutyric acid and Lesch-Nyhan Syndrome
| Article | Year |
|---|---|
Biochemical evidence of dysfunction of brain neurotransmitters in the Lesch-Nyhan syndrome.
Topics: Acetylcholine; Adenine Phosphoribosyltransferase; Adolescent; Adult; Brain; Child; Child, Preschool; | 1981 |
Gabapentin for self-injurious behavior in Lesch-Nyhan syndrome.
Topics: Acetates; Amines; Child, Preschool; Cyclohexanecarboxylic Acids; GABA Agonists; Gabapentin; gamma-Am | 1999 |
Serotonin-GABA treatment is hypothesized for self-injury in Lesch-Nyhan syndrome.
Topics: Baclofen; Drug Therapy, Combination; gamma-Aminobutyric Acid; Humans; Kynurenine; Lesch-Nyhan Syndro | 1992 |
Lesch-Nyhan syndrome: reduced amino acid concentrations in CSF and brain.
Topics: Amino Acids; Brain; Cystathionine; gamma-Aminobutyric Acid; Humans; Hypoxanthine Phosphoribosyltrans | 1989 |
Brain benzodiazepine receptor binding and purine concentration in Lesch-Nyhan syndrome.
Topics: Adolescent; Adult; Cerebral Cortex; gamma-Aminobutyric Acid; Humans; Hypoxanthine; Hypoxanthines; In | 1985 |