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gamma-aminobutyric acid and Kidney Neoplasms

gamma-aminobutyric acid has been researched along with Kidney Neoplasms in 6 studies

gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.

Kidney Neoplasms: Tumors or cancers of the KIDNEY.

Research Excerpts

ExcerptRelevanceReference
"In the renal cell carcinoma, in contrast with GBM, (13) C multiplets of γ-aminobutyric acid (GABA) differed from its precursor glutamate, suggesting that GABA did not derive from a common glutamate precursor pool."1.38Glucose metabolism via the pentose phosphate pathway, glycolysis and Krebs cycle in an orthotopic mouse model of human brain tumors. ( Bachoo, RM; Cho, SK; Choi, C; Deberardinis, RJ; Good, LB; Hatanpaa, KJ; Jindal, A; Kapur, P; Maher, EA; Malloy, CR; Marin-Valencia, I; Mashimo, T; Mickey, B; Pascual, JM; Raisanen, J; Rakheja, D; Sun, X; Takahashi, M; Togao, O; Vemireddy, V, 2012)
"Gamma-aminobutyric acid (GABA) was first discovered as an inhibitory neurotransmitter in the central nervous system (CNS) and has been reported to have a variety of functions, including regulation of cell division, cell differentiation and maturation, and to be involved in the development of certain cancers outside the CNS."1.34Invasive ability of human renal cell carcinoma cell line Caki-2 is accelerated by gamma-aminobutyric acid, via sustained activation of ERK1/2 inducible matrix metalloproteinases. ( Azuma, H; Inamoto, T; Katsuoka, Y; Kiyama, S; Kotake, Y; Sakamoto, T; Ubai, T; Watanabe, M, 2007)
"In the present study, using the human renal cell carcinoma cell line Caki-2, we demonstrated that GABA stimulation significantly increased the expression of MMP-2 and -9 and subsequently increased the invasive activity of the cancer cells."1.34Invasive ability of human renal cell carcinoma cell line Caki-2 is accelerated by gamma-aminobutyric acid, via sustained activation of ERK1/2 inducible matrix metalloproteinases. ( Azuma, H; Inamoto, T; Katsuoka, Y; Kiyama, S; Kotake, Y; Sakamoto, T; Ubai, T; Watanabe, M, 2007)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (33.33)18.2507
2000's2 (33.33)29.6817
2010's2 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Marin-Valencia, I1
Cho, SK1
Rakheja, D1
Hatanpaa, KJ1
Kapur, P1
Mashimo, T1
Jindal, A1
Vemireddy, V1
Good, LB1
Raisanen, J1
Sun, X1
Mickey, B1
Choi, C1
Takahashi, M1
Togao, O1
Pascual, JM1
Deberardinis, RJ1
Maher, EA1
Malloy, CR1
Bachoo, RM1
Nakashima, T1
Kiba, T1
Ogawa, Y1
Hosokawa, A1
Shintani, H1
Okada, Y1
Taniguchi, T1
Shigeta, M1
Kozawa, K1
Oefelein, MG1
Bayazit, Y1
Inamoto, T1
Azuma, H1
Sakamoto, T1
Kiyama, S1
Ubai, T1
Kotake, Y1
Watanabe, M1
Katsuoka, Y1
de la Iglesia, FA1
Gough, AW2
Sigler, RE2
Dominick, MA1
Robertson, DG1
Bleavins, MR1
Bobrowski, WF1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Treatment Development of Triheptanoin for Glucose Transporter Type I Deficiency[NCT02021526]Phase 1/Phase 20 participants (Actual)Interventional2015-12-31Withdrawn (stopped due to NIH funding resulted in new clinical trial)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

6 other studies available for gamma-aminobutyric acid and Kidney Neoplasms

ArticleYear
Glucose metabolism via the pentose phosphate pathway, glycolysis and Krebs cycle in an orthotopic mouse model of human brain tumors.
    NMR in biomedicine, 2012, Volume: 25, Issue:10

    Topics: Animals; Brain Neoplasms; Carcinoma, Renal Cell; Citric Acid Cycle; Disease Models, Animal; gamma-Am

2012
[A case of paclitaxel-induced peripheral neuropathy successfully treated with pregabalin].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2012, Volume: 39, Issue:9

    Topics: Antineoplastic Combined Chemotherapy Protocols; gamma-Aminobutyric Acid; Humans; Kidney Neoplasms; M

2012
Chronic pain syndrome after laparoscopic radical nephrectomy.
    The Journal of urology, 2003, Volume: 170, Issue:5

    Topics: Acetates; Aged; Amines; Analgesics; Analgesics, Opioid; Carcinoma, Renal Cell; Carcinoma, Transition

2003
Invasive ability of human renal cell carcinoma cell line Caki-2 is accelerated by gamma-aminobutyric acid, via sustained activation of ERK1/2 inducible matrix metalloproteinases.
    Cancer investigation, 2007, Volume: 25, Issue:7

    Topics: Carcinoma, Renal Cell; Cell Line, Tumor; Enzyme Activation; gamma-Aminobutyric Acid; Humans; Kidney

2007
alpha2u-Globulin nephropathy and ravens: do ravens of a different feather flock together?
    Environmental health perspectives, 1997, Volume: 105, Issue:9

    Topics: Acetates; Alpha-Globulins; Amines; Animals; Anticonvulsants; Carcinogenicity Tests; Cyclohexanecarbo

1997
Alpha 2u-globulin nephropathy without nephrocarcinogenesis in male Wistar rats administered 1-(aminomethyl)cyclohexaneacetic acid.
    Toxicology and applied pharmacology, 1991, Volume: 111, Issue:3

    Topics: Acetates; Alpha-Globulins; Amines; Animals; Chromatography, Gel; Cyclohexanecarboxylic Acids; Dose-R

1991