gamma-aminobutyric acid has been researched along with Invasiveness, Neoplasm in 12 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine the analgesic effect of the addition of gabapentin to opioids in the management of neuropathic cancer pain." | 9.11 | Gabapentin for neuropathic cancer pain: a randomized controlled trial from the Gabapentin Cancer Pain Study Group. ( Arcuri, E; Barbieri, M; Bonezzi, C; Caraceni, A; De Conno, F; Gorni, G; Maltoni, M; Martini, C; Tirelli, W; Visentin, M; Yaya Tur, R; Zecca, E, 2004) |
| "Gabapentin is effective in improving analgesia in patients with neuropathic cancer pain already treated with opioids." | 9.11 | Gabapentin for neuropathic cancer pain: a randomized controlled trial from the Gabapentin Cancer Pain Study Group. ( Arcuri, E; Barbieri, M; Bonezzi, C; Caraceni, A; De Conno, F; Gorni, G; Maltoni, M; Martini, C; Tirelli, W; Visentin, M; Yaya Tur, R; Zecca, E, 2004) |
| "Gabapentin was titrated from 600 mg/d to 1,800 mg/d in addition to stable opioid dose." | 6.71 | Gabapentin for neuropathic cancer pain: a randomized controlled trial from the Gabapentin Cancer Pain Study Group. ( Arcuri, E; Barbieri, M; Bonezzi, C; Caraceni, A; De Conno, F; Gorni, G; Maltoni, M; Martini, C; Tirelli, W; Visentin, M; Yaya Tur, R; Zecca, E, 2004) |
| "To determine the analgesic effect of the addition of gabapentin to opioids in the management of neuropathic cancer pain." | 5.11 | Gabapentin for neuropathic cancer pain: a randomized controlled trial from the Gabapentin Cancer Pain Study Group. ( Arcuri, E; Barbieri, M; Bonezzi, C; Caraceni, A; De Conno, F; Gorni, G; Maltoni, M; Martini, C; Tirelli, W; Visentin, M; Yaya Tur, R; Zecca, E, 2004) |
| "Gabapentin is effective in improving analgesia in patients with neuropathic cancer pain already treated with opioids." | 5.11 | Gabapentin for neuropathic cancer pain: a randomized controlled trial from the Gabapentin Cancer Pain Study Group. ( Arcuri, E; Barbieri, M; Bonezzi, C; Caraceni, A; De Conno, F; Gorni, G; Maltoni, M; Martini, C; Tirelli, W; Visentin, M; Yaya Tur, R; Zecca, E, 2004) |
| "Gabapentin was titrated from 600 mg/d to 1,800 mg/d in addition to stable opioid dose." | 2.71 | Gabapentin for neuropathic cancer pain: a randomized controlled trial from the Gabapentin Cancer Pain Study Group. ( Arcuri, E; Barbieri, M; Bonezzi, C; Caraceni, A; De Conno, F; Gorni, G; Maltoni, M; Martini, C; Tirelli, W; Visentin, M; Yaya Tur, R; Zecca, E, 2004) |
| "The data suggest that GABA inhibits colon cancer cell proliferation perhaps by attenuating EGR1-NR4A1 axis, EGR1-Fos axis, and by disrupting MEK-EGR1 signaling pathway." | 1.43 | γ-Aminobutyric acid inhibits the proliferation and increases oxaliplatin sensitivity in human colon cancer cells. ( Du, A; Jiang, J; Song, L; Tian, Z; Xiong, Y; Yan, H; Zhang, Y, 2016) |
| "Baclofen-induced breast cancer metastasis was mediated by ERK1/2 pathway." | 1.40 | GABAergic signaling facilitates breast cancer metastasis by promoting ERK1/2-dependent phosphorylation. ( Li, J; Li, X; Ning, N; Wei, C; Yao, Z; Zhang, D, 2014) |
| "Gabapentin, which has been suggested as an adjuvant analgesic for neuropathic pain introduced orally, rapidly and significantly alleviated his pain and we could subsequently dispense with ketamine and mexiletine." | 1.34 | [Gabapentin mitigates neuropathic pain in cancer patients--a case report]. ( Okada, M; Shinjo, T, 2007) |
| "His neuropathic pain was not sufficiently responsive to the combination therapy of opioids, non-steroidal antiinflammatory drugs (NSAIDs), continuous infusion of subcutaneous ketamine and oral mexiletine." | 1.34 | [Gabapentin mitigates neuropathic pain in cancer patients--a case report]. ( Okada, M; Shinjo, T, 2007) |
| "Gamma-aminobutyric acid (GABA) was first discovered as an inhibitory neurotransmitter in the central nervous system (CNS) and has been reported to have a variety of functions, including regulation of cell division, cell differentiation and maturation, and to be involved in the development of certain cancers outside the CNS." | 1.34 | Invasive ability of human renal cell carcinoma cell line Caki-2 is accelerated by gamma-aminobutyric acid, via sustained activation of ERK1/2 inducible matrix metalloproteinases. ( Azuma, H; Inamoto, T; Katsuoka, Y; Kiyama, S; Kotake, Y; Sakamoto, T; Ubai, T; Watanabe, M, 2007) |
| "In the present study, using the human renal cell carcinoma cell line Caki-2, we demonstrated that GABA stimulation significantly increased the expression of MMP-2 and -9 and subsequently increased the invasive activity of the cancer cells." | 1.34 | Invasive ability of human renal cell carcinoma cell line Caki-2 is accelerated by gamma-aminobutyric acid, via sustained activation of ERK1/2 inducible matrix metalloproteinases. ( Azuma, H; Inamoto, T; Katsuoka, Y; Kiyama, S; Kotake, Y; Sakamoto, T; Ubai, T; Watanabe, M, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (50.00) | 29.6817 |
| 2010's | 6 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Koh, M | 1 |
| Lee, JC | 1 |
| Min, C | 1 |
| Moon, A | 1 |
| Jiang, YM | 1 |
| Sun, DD | 1 |
| Wang, ZG | 1 |
| Li, T | 1 |
| Zhao, XL | 1 |
| Jiao, Y | 1 |
| Liu, Y | 1 |
| Li, YJ | 1 |
| Ouyang, JF | 1 |
| Wang, DQ | 1 |
| Zhang, D | 1 |
| Li, X | 1 |
| Yao, Z | 1 |
| Wei, C | 1 |
| Ning, N | 1 |
| Li, J | 1 |
| Zhang, X | 1 |
| Du, Z | 1 |
| Liu, J | 1 |
| He, J | 1 |
| Song, L | 1 |
| Du, A | 1 |
| Xiong, Y | 1 |
| Jiang, J | 1 |
| Zhang, Y | 1 |
| Tian, Z | 1 |
| Yan, H | 1 |
| Weis, SM | 1 |
| Stupack, DG | 1 |
| Cheresh, DA | 1 |
| Shibahara, H | 1 |
| Okubo, K | 1 |
| Takeshita, N | 1 |
| Nishimura, D | 1 |
| Pelham, A | 1 |
| Lee, MA | 1 |
| Regnard, CB | 1 |
| Ortega, A | 1 |
| Caraceni, A | 1 |
| Zecca, E | 1 |
| Bonezzi, C | 1 |
| Arcuri, E | 1 |
| Yaya Tur, R | 1 |
| Maltoni, M | 1 |
| Visentin, M | 1 |
| Gorni, G | 1 |
| Martini, C | 1 |
| Tirelli, W | 1 |
| Barbieri, M | 1 |
| De Conno, F | 1 |
| Okada, M | 1 |
| Shinjo, T | 1 |
| Inamoto, T | 1 |
| Azuma, H | 1 |
| Sakamoto, T | 1 |
| Kiyama, S | 1 |
| Ubai, T | 1 |
| Kotake, Y | 1 |
| Watanabe, M | 1 |
| Katsuoka, Y | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pregabalin for Pain Reduction in Critical Limb Ischemia - A Double Blind, Randomized Controlled Study[NCT00403780] | Phase 4 | 18 participants (Actual) | Interventional | 2006-06-30 | Terminated (stopped due to low inclusion rate) | ||
| Randomized Phase II Trial Evaluating Activity and Tolerability of Fixed Dose of Oxycodone and Increasing Dose of Pregabalin Versus Increasing Dose of Oxycodone and Fixed Dose of Pregabalin for the Treatment of Oncological Neuropathic Pain[NCT00637975] | Phase 2 | 80 participants (Anticipated) | Interventional | 2007-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for gamma-aminobutyric acid and Invasiveness, Neoplasm
| Article | Year |
|---|---|
Γ-aminobutyric acid receptors affect the progression and migration of tumor cells.
Topics: Animals; Carcinogenesis; Cell Movement; Cell Proliferation; gamma-Aminobutyric Acid; Humans; Models, | 2014 |
A new role for GABA: inhibition of tumor cell migration.
Topics: Animals; Baclofen; Cell Movement; GABA Agonists; gamma-Aminobutyric Acid; Humans; Neoplasm Invasiven | 2003 |
1 trial available for gamma-aminobutyric acid and Invasiveness, Neoplasm
| Article | Year |
|---|---|
Gabapentin for neuropathic cancer pain: a randomized controlled trial from the Gabapentin Cancer Pain Study Group.
Topics: Acetates; Aged; Amines; Analgesics; Analgesics, Opioid; Cyclohexanecarboxylic Acids; Double-Blind Me | 2004 |
Gabapentin for neuropathic cancer pain: a randomized controlled trial from the Gabapentin Cancer Pain Study Group.
Topics: Acetates; Aged; Amines; Analgesics; Analgesics, Opioid; Cyclohexanecarboxylic Acids; Double-Blind Me | 2004 |
Gabapentin for neuropathic cancer pain: a randomized controlled trial from the Gabapentin Cancer Pain Study Group.
Topics: Acetates; Aged; Amines; Analgesics; Analgesics, Opioid; Cyclohexanecarboxylic Acids; Double-Blind Me | 2004 |
Gabapentin for neuropathic cancer pain: a randomized controlled trial from the Gabapentin Cancer Pain Study Group.
Topics: Acetates; Aged; Amines; Analgesics; Analgesics, Opioid; Cyclohexanecarboxylic Acids; Double-Blind Me | 2004 |
9 other studies available for gamma-aminobutyric acid and Invasiveness, Neoplasm
| Article | Year |
|---|---|
A novel metformin derivative, HL010183, inhibits proliferation and invasion of triple-negative breast cancer cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Disease Models, Ani | 2013 |
[Analgesic effect and central mechanisms of CQ prescription on cancer invasion induced mirror image pain in model mice].
Topics: Analgesics; Animals; Drugs, Chinese Herbal; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Male; M | 2017 |
GABAergic signaling facilitates breast cancer metastasis by promoting ERK1/2-dependent phosphorylation.
Topics: Animals; Breast Neoplasms; Cell Movement; Dose-Response Relationship, Drug; Female; GABA-B Receptor | 2014 |
γ-Aminobutyric acid inhibits the proliferation and increases oxaliplatin sensitivity in human colon cancer cells.
Topics: Animals; Antineoplastic Agents; Base Sequence; Cell Line, Tumor; Cell Movement; Cell Proliferation; | 2016 |
Agonizing integrin antagonists?
Topics: Animals; Benzocycloheptenes; Cell Proliferation; Dose-Response Relationship, Drug; gamma-Aminobutyri | 2009 |
[Medical treatment including pregabalin and radiation therapy provided remarkable relief for neuropathic pain by brachial plexus invasion in a patient with esophageal cancer].
Topics: Analgesics; Brachial Plexus; Esophageal Neoplasms; gamma-Aminobutyric Acid; Humans; Magnetic Resonan | 2012 |
Gabapentin for coeliac plexus pain.
Topics: Acetates; Aged; Amines; Analgesics; Celiac Plexus; Cyclohexanecarboxylic Acids; Female; Gabapentin; | 2002 |
[Gabapentin mitigates neuropathic pain in cancer patients--a case report].
Topics: Adenocarcinoma; Amines; Analgesics; Bone Neoplasms; Cyclohexanecarboxylic Acids; Gabapentin; gamma-A | 2007 |
Invasive ability of human renal cell carcinoma cell line Caki-2 is accelerated by gamma-aminobutyric acid, via sustained activation of ERK1/2 inducible matrix metalloproteinases.
Topics: Carcinoma, Renal Cell; Cell Line, Tumor; Enzyme Activation; gamma-Aminobutyric Acid; Humans; Kidney | 2007 |