Compounds > gamma-aminobutyric acid
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gamma-aminobutyric acid and Innate Inflammatory Response

gamma-aminobutyric acid has been researched along with Innate Inflammatory Response in 140 studies

gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.

Research Excerpts

ExcerptRelevanceReference
" Because the involvement of local inhibition in the dorsal horn, specifically that mediated by the inhibitory amino acids GABA and glycine, is so important in signal processing, we investigated regional inhibitory control of excitatory interneurons under control conditions and peripheral inflammation-induced mechanical allodynia."7.85Inhibition Mediated by Glycinergic and GABAergic Receptors on Excitatory Neurons in Mouse Superficial Dorsal Horn Is Location-Specific but Modified by Inflammation. ( Choudhury, P; Conway, CM; Flood, PD; MacDermott, AB; Mukai, J; Scherrer, G; Takazawa, T; Tong, CK, 2017)
" Sulforaphane could be a new therapeutic approach to improve cognitive and motor function in hyperammonemia, hepatic encephalopathy, and other pathologies associated with neuroinflammation by promoting microglia differentiation from M1 to M2."7.83Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia. ( Agusti, A; Balzano, T; Cabrera-Pastor, A; Felipo, V; Gonzalez-Usano, A; Hernandez-Rabaza, V; Llansola, M; Taoro-Gonzalez, L, 2016)
"Dose response curves for nonsedating doses of morphine and CNSB002 given intraperitoneally alone and together in combinations were constructed for antihyperalgesic effect using paw withdrawal from noxious heat in two rat pain models: carrageenan-induced paw inflammation and streptozotocin (STZ)-induced diabetic neuropathy."7.76Studies of synergy between morphine and a novel sodium channel blocker, CNSB002, in rat models of inflammatory and neuropathic pain. ( Cooke, I; Goodchild, CS; Kolosov, A, 2010)
"This study determined the antihyperalgesic effect of CNSB002, a sodium channel blocker with antioxidant properties given alone and in combinations with morphine in rat models of inflammatory and neuropathic pain."7.76Studies of synergy between morphine and a novel sodium channel blocker, CNSB002, in rat models of inflammatory and neuropathic pain. ( Cooke, I; Goodchild, CS; Kolosov, A, 2010)
"The GABA amides of the antidepressants nortriptyline and fluoxetine, 1 and 2, were compared to their respective parent compounds in rodent models of pain."7.75Gamma-aminobutyric acid amides of nortriptyline and fluoxetine display improved pain suppressing activity. ( Aharoni, A; Geffen, Y; Gil-Ad, I; Halbfinger, E; Nisemblat, Y; Nudelman, A; Rephaeli, A; Tarasenko, I; Tarasenko, N; Weizman, A, 2009)
" In this study, we investigated their actions on substance P-induced NF-kappaB activation in human neuroblastoma and rat glioma cells."7.74Pregabalin and gabapentin inhibit substance P-induced NF-kappaB activation in neuroblastoma and glioma cells. ( Ahn, ES; Han, DW; Hong, YW; Kim, H; Lee, JH; Min, KT; Park, S, 2008)
"This study investigated the anti-allodynic and anti-oedematogenic effects of the hexanic extract, lignan-rich fraction and purified lignans from a plant used in the traditional medicine, Phyllanthus amarus, in the inflammatory and neuropathic models of nociception."7.72Anti-allodynic and anti-oedematogenic properties of the extract and lignans from Phyllanthus amarus in models of persistent inflammatory and neuropathic pain. ( Calixto, JB; Kassuya, CA; Rehder, VL; Silvestre, AA, 2003)
" When evaluated in the model of neuropathic pain caused by partial ligation of sciatic nerve, the hexanic extract inhibited the mechanical allodynia (77 +/- 7%), with a similar efficacy to the gabapentin (71 +/- 10%)."7.72Anti-allodynic and anti-oedematogenic properties of the extract and lignans from Phyllanthus amarus in models of persistent inflammatory and neuropathic pain. ( Calixto, JB; Kassuya, CA; Rehder, VL; Silvestre, AA, 2003)
" The present study was thus designed to determine the effects of unilateral peripheral inflammation on ventrocaudal PAG gamma-aminobutyric acid (GABA) release in the rat using in vivo microdialysis and subsequent high pressure liquid chromatography (HPLC) analysis."7.70Peripheral inflammation is associated with decreased veratridine-induced release of GABA in the rat ventrocaudal periaqueductal gray: microdialysis study. ( Beitz, AJ; Renno, WM, 1999)
"An increase in the number of gamma-aminobutyric acid (GABA)-immunoreactive cells is reported in the superficial dorsal horn of the rat spinal cord upon unilateral inflammation of the hind foot caused by subcutaneous carrageenan injection."7.69Carrageenan-induced inflammation of the hind foot provokes a rise of GABA-immunoreactive cells in the rat spinal cord that is prevented by peripheral neurectomy or neonatal capsaicin treatment. ( Castro-Lopes, JM; Coimbra, A; Tavares, I; Tölle, TR, 1994)
"Chronic pain is a multifactorial disease comprised of both inflammatory and neuropathic components that affect ∼20% of the world's population."5.46sec-Butylpropylacetamide (SPD), a new amide derivative of valproic acid for the treatment of neuropathic and inflammatory pain. ( Bialer, M; Brennan, KC; Devor, M; Kaufmann, D; Smith, MD; West, PJ; White, HS; Yagen, B, 2017)
"Sulforaphane promotes polarization of microglia from the M1 to the M2 phenotype, reducing IL-1b and increasing IL-4, IL-10, Arg1, and YM-1 in the cerebellum."5.43Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia. ( Agusti, A; Balzano, T; Cabrera-Pastor, A; Felipo, V; Gonzalez-Usano, A; Hernandez-Rabaza, V; Llansola, M; Taoro-Gonzalez, L, 2016)
"Ambroxol's effects were compared with those of gabapentin."5.33Ambroxol, a Nav1.8-preferring Na(+) channel blocker, effectively suppresses pain symptoms in animal models of chronic, neuropathic and inflammatory pain. ( Arndt, K; Gaida, W; Klinder, K; Weiser, T, 2005)
"Neuropathic pain affects many patients, and treatment today is far from being perfect."5.33Ambroxol, a Nav1.8-preferring Na(+) channel blocker, effectively suppresses pain symptoms in animal models of chronic, neuropathic and inflammatory pain. ( Arndt, K; Gaida, W; Klinder, K; Weiser, T, 2005)
"Gabapentin (Neurontin) is a novel anticonvulsant with an as yet unknown mechanism of action."5.30Gabapentin, ineffective in normal rats, markedly reduces C-fibre evoked responses after inflammation. ( Dickenson, AH; Singh, L; Stanfa, LC; Williams, RG, 1997)
" High-energy diet, saturated fats and trans-fats during perinatal period could suppress Delta(6) and Delta(5) desaturases both in the maternal and fetal tissues, resulting in a decrease in the concentrations of long-chain polyunsaturated fatty acids (LCPUFAs): arachidonic acid (AA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) that have a negative feedback control on inflammation."4.84Is metabolic syndrome X a disorder of the brain with the initiation of low-grade systemic inflammatory events during the perinatal period? ( Das, UN, 2007)
"Rats were treated with golexanolone and effects on peripheral inflammation, neuroinflammation, TNFR1-glutaminase-GAT3 and TNFR1-CCL2-TrkB-KCC2 pathways, and cognitive and motor function were analyzed."4.12Golexanolone, a GABA ( Bäckström, T; Blackburn, TP; Doverskog, M; Felipo, V; Gimenez-Garzo, C; Hällgren, A; Izquierdo-Altarejos, P; Llansola, M; Martinez-Garcia, M; Mincheva, G, 2022)
" This was associated with reversal of the hyperammonemia-enhanced activation in cerebellum of the TNFR1-glutaminase-GAT3 and TNFR1-CCL2-TrkB-KCC2 pathways."4.12Golexanolone, a GABA ( Bäckström, T; Blackburn, TP; Doverskog, M; Felipo, V; Gimenez-Garzo, C; Hällgren, A; Izquierdo-Altarejos, P; Llansola, M; Martinez-Garcia, M; Mincheva, G, 2022)
"In vivo, mice were sensitized and challenged by ovalbumin (OVA) to induce asthma."3.96Monocyte chemotactic protein-inducing protein 1 negatively regulating asthmatic airway inflammation and mucus hypersecretion involving γ-aminobutyric acid type A receptor signaling pathway in vivo and in vitro. ( Chen, ZH; Dai, GM; Deng, HJ; Mao, RL; Ran, YJ; Wang, JJ; Zhu, T, 2020)
" Here, we examined whether levels of immunological protein markers changed with depression, age, or the inhibitory neurotransmitter gamma-aminobutyric acid (GABA)."3.91Depression, GABA, and Age Correlate with Plasma Levels of Inflammatory Markers. ( Bhandage, AK; Birnir, B; Bongiovanni, S; Cunningham, JL; Ekselius, L; Jin, Z; Kamali-Moghaddam, M; Korol, SV; Shen, Q; Syk, M, 2019)
" We found that 24-h after CFA-induced knee inflammation, knee neurons show a decreased action potential generation threshold, as well as increased GABA and capsaicin sensitivity, but have unaltered acid sensitivity."3.88Acute inflammation sensitizes knee-innervating sensory neurons and decreases mouse digging behavior in a TRPV1-dependent manner. ( Callejo, G; Chakrabarti, S; Hockley, JRF; Pattison, LA; Singhal, K; Smith, ESJ, 2018)
" Because the involvement of local inhibition in the dorsal horn, specifically that mediated by the inhibitory amino acids GABA and glycine, is so important in signal processing, we investigated regional inhibitory control of excitatory interneurons under control conditions and peripheral inflammation-induced mechanical allodynia."3.85Inhibition Mediated by Glycinergic and GABAergic Receptors on Excitatory Neurons in Mouse Superficial Dorsal Horn Is Location-Specific but Modified by Inflammation. ( Choudhury, P; Conway, CM; Flood, PD; MacDermott, AB; Mukai, J; Scherrer, G; Takazawa, T; Tong, CK, 2017)
" Sulforaphane could be a new therapeutic approach to improve cognitive and motor function in hyperammonemia, hepatic encephalopathy, and other pathologies associated with neuroinflammation by promoting microglia differentiation from M1 to M2."3.83Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia. ( Agusti, A; Balzano, T; Cabrera-Pastor, A; Felipo, V; Gonzalez-Usano, A; Hernandez-Rabaza, V; Llansola, M; Taoro-Gonzalez, L, 2016)
" Systemic administration of 1 reduced acetic acid-induced writhing, the inflammatory phase of formalin-induced pain, and capsaicin-induced mechanical allodynia."3.79Antiallodynic and analgesic effects of maslinic acid, a pentacyclic triterpenoid from Olea europaea. ( Baeyens, JM; Cobos, EJ; Entrena, JM; García-Granados, A; Nieto, FR; Parra, A, 2013)
" We combine pharmacological, genetic, and electrophysiological approaches to show that cortical GluK1-containing kainate (KA) receptors are involved in scratching induced by histamine and non-histamine-dependent itching stimuli."3.79Cortical GluK1 kainate receptors modulate scratching in adult mice. ( Chen, T; Descalzi, G; Koga, K; Li, XY; Yamada, K; Zhuo, M, 2013)
"Transcriptomic and proteomic analyses of multiple sclerosis (MS) lesions indicate alterations in the gamma-aminobutyric acid (GABA) inhibitory system, suggesting its involvement in the disease process."3.79Systemic treatment with the inhibitory neurotransmitter γ-aminobutyric acid aggravates experimental autoimmune encephalomyelitis by affecting proinflammatory immune responses. ( Carmans, S; Hellings, N; Hendriks, JJ; Rigo, JM; Slaets, H; Stinissen, P; Thewissen, K, 2013)
" We hypothesized that the volatile anesthetic sevoflurane (SEVO) attenuates lung inflammation through activation of lung epithelial GABA(A) receptors."3.78Effects of anesthetic regimes on inflammatory responses in a rat model of acute lung injury. ( Fortis, S; Haitsma, JJ; Lu, WY; Mazer, CD; Parotto, M; Slutsky, AS; Spieth, PM; Zhang, H; Zhong, N, 2012)
"This study determined the antihyperalgesic effect of CNSB002, a sodium channel blocker with antioxidant properties given alone and in combinations with morphine in rat models of inflammatory and neuropathic pain."3.76Studies of synergy between morphine and a novel sodium channel blocker, CNSB002, in rat models of inflammatory and neuropathic pain. ( Cooke, I; Goodchild, CS; Kolosov, A, 2010)
"Dose response curves for nonsedating doses of morphine and CNSB002 given intraperitoneally alone and together in combinations were constructed for antihyperalgesic effect using paw withdrawal from noxious heat in two rat pain models: carrageenan-induced paw inflammation and streptozotocin (STZ)-induced diabetic neuropathy."3.76Studies of synergy between morphine and a novel sodium channel blocker, CNSB002, in rat models of inflammatory and neuropathic pain. ( Cooke, I; Goodchild, CS; Kolosov, A, 2010)
"The present study investigated the effects of systemic administration of dexmedetomidine, a selective alpha2 adrenergic receptor (alpha2AR) agonist, and gabapentin either alone or in combination on thermal hyperalgesia evoked by ankle joint inflammation."3.75Antihyperalgesic effect of systemic dexmedetomidine and gabapentin in a rat model of monoarthritis. ( Deng, XM; Sun, S; Xu, B; Xu, H; Zhang, WS; Zhang, YQ, 2009)
"The GABA amides of the antidepressants nortriptyline and fluoxetine, 1 and 2, were compared to their respective parent compounds in rodent models of pain."3.75Gamma-aminobutyric acid amides of nortriptyline and fluoxetine display improved pain suppressing activity. ( Aharoni, A; Geffen, Y; Gil-Ad, I; Halbfinger, E; Nisemblat, Y; Nudelman, A; Rephaeli, A; Tarasenko, I; Tarasenko, N; Weizman, A, 2009)
" In this study, we investigated their actions on substance P-induced NF-kappaB activation in human neuroblastoma and rat glioma cells."3.74Pregabalin and gabapentin inhibit substance P-induced NF-kappaB activation in neuroblastoma and glioma cells. ( Ahn, ES; Han, DW; Hong, YW; Kim, H; Lee, JH; Min, KT; Park, S, 2008)
"Duloxetine, a selective but balanced serotonergic and noradrenergic reuptake inhibitor, was evaluated in the acute nociceptive pain models of tail flick and hot plate in mice and in the persistent and/or inflammatory pain models of acetic acid-induced writhing in mice, carrageenan-induced thermal hyperalgesia and mechanical allodynia in rats, and capsaicin-induced mechanical allodynia in rats."3.73Efficacy of duloxetine, a potent and balanced serotonergic and noradrenergic reuptake inhibitor, in inflammatory and acute pain models in rodents. ( Jones, CK; Peters, SC; Shannon, HE, 2005)
" The effects of diacerhein were compared with those of gabapentin, a drug used clinically for the management of neuropathic pain."3.73The effects of diacerhein on mechanical allodynia in inflammatory and neuropathic models of nociception in mice. ( Calixto, JB; Campos, MM; Medeiros, R; Quintão, NLM; Santos, ARS, 2005)
"This study investigated the anti-allodynic and anti-oedematogenic effects of the hexanic extract, lignan-rich fraction and purified lignans from a plant used in the traditional medicine, Phyllanthus amarus, in the inflammatory and neuropathic models of nociception."3.72Anti-allodynic and anti-oedematogenic properties of the extract and lignans from Phyllanthus amarus in models of persistent inflammatory and neuropathic pain. ( Calixto, JB; Kassuya, CA; Rehder, VL; Silvestre, AA, 2003)
" When evaluated in the model of neuropathic pain caused by partial ligation of sciatic nerve, the hexanic extract inhibited the mechanical allodynia (77 +/- 7%), with a similar efficacy to the gabapentin (71 +/- 10%)."3.72Anti-allodynic and anti-oedematogenic properties of the extract and lignans from Phyllanthus amarus in models of persistent inflammatory and neuropathic pain. ( Calixto, JB; Kassuya, CA; Rehder, VL; Silvestre, AA, 2003)
" Recent electrophysiological studies by our group have suggested that increased excitation of spinal GABAergic neurons by activation of N-methyl-D-aspartate (NMDA) and non-NMDA receptors following intradermal injection of capsaicin results in the generation of DRRs that contribute to neurogenic inflammation."3.71NMDA or non-NMDA receptor antagonists attenuate increased Fos expression in spinal dorsal horn GABAergic neurons after intradermal injection of capsaicin in rats. ( Lin, Q; Willis, WD; Zou, X, 2001)
" To resolve this issue, we combined immunocytochemical and patch recording techniques to study the actions of GBP on NMDA receptors in dorsal horn cells isolated from rats with inflammation and to determine the gamma-aminobutyric acid (GABA) content in the recorded cells."3.71Gabapentin potentiates N-methyl-D-aspartate receptor mediated currents in rat GABAergic dorsal horn neurons. ( Gu, Y; Huang, LY, 2002)
" The present study was thus designed to determine the effects of unilateral peripheral inflammation on ventrocaudal PAG gamma-aminobutyric acid (GABA) release in the rat using in vivo microdialysis and subsequent high pressure liquid chromatography (HPLC) analysis."3.70Peripheral inflammation is associated with decreased veratridine-induced release of GABA in the rat ventrocaudal periaqueductal gray: microdialysis study. ( Beitz, AJ; Renno, WM, 1999)
"An increase in the number of gamma-aminobutyric acid (GABA)-immunoreactive cells is reported in the superficial dorsal horn of the rat spinal cord upon unilateral inflammation of the hind foot caused by subcutaneous carrageenan injection."3.69Carrageenan-induced inflammation of the hind foot provokes a rise of GABA-immunoreactive cells in the rat spinal cord that is prevented by peripheral neurectomy or neonatal capsaicin treatment. ( Castro-Lopes, JM; Coimbra, A; Tavares, I; Tölle, TR, 1994)
"Further, large areas of mechanical hyperalgesia to pinprick adjacent to the erythema spots developed in all subjects."2.71The effects of remifentanil and gabapentin on hyperalgesia in a new extended inflammatory skin pain model in healthy volunteers. ( Felouzis, E; Gustorff, B; Hoechtl, K; Kress, HG; Lehr, S; Sycha, T, 2004)
"Neuropathology of hepatic encephalopathy (HE) in cirrhosis is primarily astroglial in nature characterized by Alzheimer type 2 astrocytosis together with activation of microglia indicative of neuroinflammation."2.61Hepatic Encephalopathy in Cirrhosis: Pathology and Pathophysiology. ( Butterworth, RF, 2019)
"Persistent neuroinflammation has been recognised as a major pathological component of virtually all neurodegenerative diseases and has also been a focus of research into the pathology underlying psychiatric disorders."2.53Inhibiting neuroinflammation: The role and therapeutic potential of GABA in neuro-immune interactions. ( Crowley, T; Cryan, JF; Downer, EJ; O'Leary, OF, 2016)
"Dementia is a progressive neurodegenerative disorder with cognitive dysfunction, and is often complicated by behavioral and psychological symptoms of dementia (BPSD) including excitement, aggression, and hallucinations."2.53Neuropharmacological efficacy of the traditional Japanese Kampo medicine yokukansan and its active ingredients. ( Ikarashi, Y; Mizoguchi, K, 2016)
"This suggests that metabolic syndrome X could be a disorder of the brain due to suboptimal LCPUFAs during perinatal period that triggers low-grade systemic inflammation, implying that perinatal strategies are needed to prevent its development."2.44Is metabolic syndrome X a disorder of the brain with the initiation of low-grade systemic inflammatory events during the perinatal period? ( Das, UN, 2007)
"Meanwhile, it decreased the seizure severity and reduced seizure-caused anxious behavior in the PTZ-kindling mice, suggesting a significant antiepileptic activity and anxiolytic/anxiogenic potential."1.91Herb pair of Polygala tenuifolia Willd and Acorus tatarinowii Schott decoction attenuates seizures and alleviates anxiety in mice: Evidence for modulating inflammation, alleviating oxidative stress and mediating GABA pathway. ( He, X; Liu, Y; Xie, Y; Yang, Y; Yuan, X, 2023)
"Inflammation is a potential risk factor of mental disturbance."1.72FKBP51 mediates resilience to inflammation-induced anxiety through regulation of glutamic acid decarboxylase 65 expression in mouse hippocampus. ( Cheng, MY; Gan, YL; He, RH; Hsieh, TH; Hsu, PC; Huang, MC; Jeng, CJ; Lee, YH; Lin, HC; Wang, CY; Yeh, HH, 2022)
"Adenomyosis is a common uterine disorder of uncertain causes."1.72Transcriptomic analysis supports collective endometrial cell migration in the pathogenesis of adenomyosis. ( Chen, ZJ; Du, Y; Giudice, LC; Irwin, JC; Li, S; Sen, S; Vallvé-Juanico, J; Vo, KC; Wan, J; Zhai, J, 2022)
"Stress-induced neuroinflammation is widely regarded as one of the primary causes of depression."1.72Rice Germ Ameliorated Chronic Unpredictable Mild Stress-Induced Depressive-like Behavior by Reducing Neuroinflammation. ( Batsukh, S; Byun, K; Lee, BJ; Oh, S; Park, CH; Rheu, K; Son, KH, 2022)
"Glaucoma is a leading cause of irreversible blindness worldwide, and increased intraocular pressure (IOP) is a major risk factor."1.62Early Functional Impairment in Experimental Glaucoma Is Accompanied by Disruption of the GABAergic System and Inceptive Neuroinflammation. ( Elwood, BW; Godwin, CR; Gramlich, OW; Kuehn, MH; Wadkins, D, 2021)
"Hyperammonemia is a main contributor to cognitive impairment and motor in-coordination in patients with hepatic encephalopathy."1.48Increasing extracellular cGMP in cerebellum in vivo reduces neuroinflammation, GABAergic tone and motor in-coordination in hyperammonemic rats. ( Balzano, T; Cabrera-Pastor, A; Felipo, V; Hernández-Rabaza, V; Llansola, M; Malaguarnera, M, 2018)
"Inflammation is considered to be one of the crucial pathological factors associated with the development of Alzheimer's disease, although supportive experimental evidence remains undiscovered."1.46Immunological alteration & toxic molecular inductions leading to cognitive impairment & neurotoxicity in transgenic mouse model of Alzheimer's disease. ( Abdel-Rahman, E; Ahuja, M; Amin, R; Buabeid, M; Dhanasekaran, M; Majrashi, M; Parameshwaran, K; Pondugula, S; Ramesh, S; Suppiramaniam, V; Thiruchelvan, K, 2017)
"Chronic pain is a multifactorial disease comprised of both inflammatory and neuropathic components that affect ∼20% of the world's population."1.46sec-Butylpropylacetamide (SPD), a new amide derivative of valproic acid for the treatment of neuropathic and inflammatory pain. ( Bialer, M; Brennan, KC; Devor, M; Kaufmann, D; Smith, MD; West, PJ; White, HS; Yagen, B, 2017)
"CFA-induced hyperalgesia and sensitivity to morphine (0."1.46Vendor-derived differences in injury-induced pain phenotype and pharmacology of Sprague-Dawley rats: Does it matter? ( Bjerrum, OJ; Heegaard, AM; Hestehave, S; Jeggo, RD; Kristensen, PJ; Munro, G, 2017)
"Sulforaphane promotes polarization of microglia from the M1 to the M2 phenotype, reducing IL-1b and increasing IL-4, IL-10, Arg1, and YM-1 in the cerebellum."1.43Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia. ( Agusti, A; Balzano, T; Cabrera-Pastor, A; Felipo, V; Gonzalez-Usano, A; Hernandez-Rabaza, V; Llansola, M; Taoro-Gonzalez, L, 2016)
"CNS inflammation is characterized by a disturbance of glial cell functions."1.40Glia and epilepsy: experimental investigation of antiepileptic drugs in an astroglia/microglia co-culture model of inflammation. ( Dambach, H; Faustmann, PM; Haase, CG; Hinkerohe, D; Hufnagel, A; Moinfar, Z; Prochnow, N; Stienen, MN, 2014)
"Gabapentin (GBP) is an anti-convulsive drug often used as analgesic to control neuropathic pain."1.39Oral gabapentin treatment accentuates nerve and peripheral inflammatory responses following experimental nerve constriction in Wistar rats. ( Araújo, CV; Barbosa, AL; Brito, GA; Câmara, CC; Costa, CM; da Silva, AP; Gomes, AS; Oriá, RB; Ramos, HF; Ribeiro, RA; Vale, ML, 2013)
"Persistent inflammation is associated with a shift in spinal GABA(A) signaling from inhibition to excitation such that GABA(A)-receptor activation contributes to inflammatory hyperalgesia."1.38Persistent inflammation increases GABA-induced depolarization of rat cutaneous dorsal root ganglion neurons in vitro. ( Gold, MS; Lu, SG; Zhu, Y, 2012)
"Inflammation was associated with a significant increase in the magnitude of GABA-induced depolarization as well as the percentage of neurons in which GABA evoked a Ca(2+) transient."1.38Persistent inflammation increases GABA-induced depolarization of rat cutaneous dorsal root ganglion neurons in vitro. ( Gold, MS; Lu, SG; Zhu, Y, 2012)
"Neuropathic pain is a common problem following spinal cord injury (SCI)."1.36Role of NKCC1 and KCC2 in the development of chronic neuropathic pain following spinal cord injury. ( Ahmed, MM; Hasbargen, T; Kahle, KT; Li, L; Miranpuri, G; Resnick, D; Sun, D, 2010)
"Gabapentin and duloxetine reversed mechanical hyperalgesia but did not normalize gait in any nerve injury model."1.35Abnormal gait, due to inflammation but not nerve injury, reflects enhanced nociception in preclinical pain models. ( Cummons, TA; Harrison, JE; Leventhal, L; Lu, P; Piesla, MJ; Strassle, BW; Whiteside, GT, 2009)
"Both indomethacin and morphine were able to block or reverse thermal hyperalgesia and normalize gait in the CARR model."1.35Abnormal gait, due to inflammation but not nerve injury, reflects enhanced nociception in preclinical pain models. ( Cummons, TA; Harrison, JE; Leventhal, L; Lu, P; Piesla, MJ; Strassle, BW; Whiteside, GT, 2009)
"In contrast, analgesia, sedation and catalepsy were not observed in this dose range, but were apparent at 100 mg/kg."1.33Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy. ( Boulet, JM; Chaffer, SM; Elsemore, DA; Gottshall, SL; Harrison, JE; Koetzner, L; Lee, G; Mark, L; Miller, W; Pearson, MS; Rabadi, L; Rotshteyn, Y; Shan, S; Tafesse, L; Toth, M; Turchin, PI; Valenzano, KJ; Whiteside, GT, 2005)
"Ambroxol's effects were compared with those of gabapentin."1.33Ambroxol, a Nav1.8-preferring Na(+) channel blocker, effectively suppresses pain symptoms in animal models of chronic, neuropathic and inflammatory pain. ( Arndt, K; Gaida, W; Klinder, K; Weiser, T, 2005)
"Neuropathic pain affects many patients, and treatment today is far from being perfect."1.33Ambroxol, a Nav1.8-preferring Na(+) channel blocker, effectively suppresses pain symptoms in animal models of chronic, neuropathic and inflammatory pain. ( Arndt, K; Gaida, W; Klinder, K; Weiser, T, 2005)
"Malondialdehyde (MDA) was measured as a marker of oxidative damage."1.31Diets enriched in foods with high antioxidant activity reverse age-induced decreases in cerebellar beta-adrenergic function and increases in proinflammatory cytokines. ( Bickford, PC; Choo, K; Gemma, C; Holmes, DB; Mesches, MH; Sepesi, B, 2002)
"Gabapentin (Neurontin) is a novel anticonvulsant with an as yet unknown mechanism of action."1.30Gabapentin, ineffective in normal rats, markedly reduces C-fibre evoked responses after inflammation. ( Dickenson, AH; Singh, L; Stanfa, LC; Williams, RG, 1997)

Research

Studies (140)

TimeframeStudies, this research(%)All Research%
pre-19901 (0.71)18.7374
1990's4 (2.86)18.2507
2000's36 (25.71)29.6817
2010's68 (48.57)24.3611
2020's31 (22.14)2.80

Authors

AuthorsStudies
Saunders, MJ1
Edwards, BS1
Zhu, J2
Sklar, LA1
Graves, SW1
Zhang, B1
Vogelzang, A1
Miyajima, M1
Sugiura, Y1
Wu, Y1
Chamoto, K1
Nakano, R1
Hatae, R1
Menzies, RJ1
Sonomura, K1
Hojo, N1
Ogawa, T1
Kobayashi, W1
Tsutsui, Y1
Yamamoto, S1
Maruya, M1
Narushima, S1
Suzuki, K1
Sugiya, H1
Murakami, K1
Hashimoto, M1
Ueno, H1
Kobayashi, T1
Ito, K1
Hirano, T1
Shiroguchi, K1
Matsuda, F1
Suematsu, M1
Honjo, T1
Fagarasan, S1
Lee, H2
Ji, SY1
Hwangbo, H1
Kim, MY1
Kim, DH1
Park, BS1
Park, JH1
Lee, BJ2
Kim, GY1
Jeon, YJ1
Choi, YH1
Zhong, H1
Rong, J1
Yang, Y4
Liang, M1
Li, Y2
Zhou, R1
Gan, YL1
Wang, CY1
He, RH1
Hsu, PC1
Yeh, HH1
Hsieh, TH1
Lin, HC1
Cheng, MY1
Jeng, CJ1
Huang, MC1
Lee, YH1
Zhai, J1
Li, S2
Sen, S1
Vallvé-Juanico, J1
Irwin, JC1
Vo, KC1
Wan, J1
Du, Y1
Chen, ZJ1
Giudice, LC1
Mincheva, G1
Gimenez-Garzo, C1
Izquierdo-Altarejos, P1
Martinez-Garcia, M1
Doverskog, M1
Blackburn, TP1
Hällgren, A1
Bäckström, T1
Llansola, M4
Felipo, V4
Zhang, D1
Liu, J1
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Tarasenko, AS1
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Lisakovska, OO1
Trikash, IO1
Jaffe, A1
Lim, JK1
Jakab, SS1
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Erdoğan, MA1
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Deng, HJ1
Mao, RL1
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Zhou, L1
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Rauvala, H1
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Molinari, F1
Rivera, C1
Lang, L1
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Lee, PR1
Yoon, SY2
Kim, HW2
Yeo, JH1
Kim, YH3
Cui, B1
Su, D1
Li, W1
She, X1
Zhang, M1
Zhai, Q1
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Singhal, K1
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Cacheaux, LP1
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Lakhter, AJ1
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Heinemann, U1
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Lu, P1
Whiteside, GT2
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Mitra, A1
Miranda, M1
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Tsien, RW1
Komai, M1
Tanaka, H1
Nagao, K1
Ishizaki, M1
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Haba, T1
Kawakami, K1
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da Silva, GF1
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de Novellis, V1
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Tian, J2
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Kwon, YB1
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Xiong, H1
Hallworth, R1
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Rafati, DS1
Geissler, K1
Johnson, K1
Unabia, G1
Hulsebosch, C1
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Aronica, E1
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Patel, S1
Naeem, S1
Kesingland, A1
Froestl, W1
Capogna, M1
Urban, L1
Fox, A1
Zou, X1
Lin, Q1
Willis, WD1
Sokal, DM1
Chapman, V1
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García Bonacho, M1
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Dalessio, DJ1

Clinical Trials (9)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Antibiotic Effects on the Developing Microbiome, Metabolome and Morbidities in Preterm Neonates[NCT02784821]Phase 2186 participants (Actual)Interventional2017-01-16Completed
A Multicenter, Prospective, Randomized Controlled Study to Explore the Efficacy and Safety of Fecal Microbiota Transplantation With Different Bacterial Doses in the Treatment of Recurrent Hepatic Encephalopathy[NCT05669651]100 participants (Anticipated)Interventional2022-12-01Active, not recruiting
Open Label Study for the Use of Transcranial Ultrasound Treatment of Attention Deficit Hyperactive Disorder[NCT04497363]100 participants (Anticipated)Interventional2020-07-01Enrolling by invitation
Anhydrous Enol-Oxaloacetate (AEO) on Improving Fatigue in Post-COVID-19 Survivors[NCT04592354]40 participants (Anticipated)Interventional2020-10-15Recruiting
Oxaloacetate Supplementation for Emotional PMS; Measuring Improvements in Depression, Anxiety, Perceived Stress, and Aggression[NCT03509714]48 participants (Actual)Interventional2016-10-17Completed
A Randomized Double Blind Placebo Controlled Trial to Determine the Effects of Oxaloacetate on Improving Fatigue in ME/CFS[NCT05273372]80 participants (Anticipated)Interventional2022-03-15Enrolling by invitation
Role of the Gut Microbiome as Determinant of Depression in Multiple Sclerosis Subjects[NCT05808101]120 participants (Anticipated)Observational2022-01-27Recruiting
Efficacy of Duloxetine in Conjunction With Tramadol for Chronic Cancer Pain[NCT05311774]400 participants (Anticipated)Interventional2022-04-30Not yet recruiting
Effect of Ambroxol on the Inflammatory Markers and Clinical Outcome of Patients With Diabetic Peripheral Neuropathy[NCT05558878]80 participants (Anticipated)Interventional2022-10-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

19 reviews available for gamma-aminobutyric acid and Innate Inflammatory Response

ArticleYear
Understanding the function of the GABAergic system and its potential role in rheumatoid arthritis.
    Frontiers in immunology, 2023, Volume: 14

    Topics: Arthritis, Rheumatoid; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Humans; Inf

2023
Review on Cross Talk between Neurotransmitters and Neuroinflammation in Striatum and Cerebellum in the Mediation of Motor Behaviour.
    BioMed research international, 2019, Volume: 2019

    Topics: Animals; Astrocytes; Central Nervous System; Cerebellum; Corpus Striatum; Cytokines; Disease Models,

2019
Pathophysiology of Hepatic Encephalopathy.
    Clinics in liver disease, 2020, Volume: 24, Issue:2

    Topics: Ammonia; Animals; Astrocytes; Diabetes Complications; gamma-Aminobutyric Acid; Gastrointestinal Micr

2020
Environmental regulation of the chloride transporter KCC2: switching inflammation off to switch the GABA on?
    Translational psychiatry, 2020, 10-15, Volume: 10, Issue:1

    Topics: Chlorides; Developmental Disabilities; Female; gamma-Aminobutyric Acid; Humans; Inflammation; Matern

2020
GABAergic signaling by cells of the immune system: more the rule than the exception.
    Cellular and molecular life sciences : CMLS, 2021, Volume: 78, Issue:15

    Topics: Animals; gamma-Aminobutyric Acid; Host Microbial Interactions; Humans; Immune System; Inflammation;

2021
Hepatic Encephalopathy in Cirrhosis: Pathology and Pathophysiology.
    Drugs, 2019, Volume: 79, Issue:Suppl 1

    Topics: Ammonia; Basal Ganglia; Cerebellum; gamma-Aminobutyric Acid; Hepatic Encephalopathy; Humans; Inflamm

2019
Neuroinflammation as a risk factor for attention deficit hyperactivity disorder.
    Pharmacology, biochemistry, and behavior, 2019, Volume: 182

    Topics: Adolescent; Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System; Child; C

2019
Toward a biosignature for suicide.
    The American journal of psychiatry, 2014, Dec-01, Volume: 171, Issue:12

    Topics: Biomarkers; Brain; Dopamine; gamma-Aminobutyric Acid; Gene Expression Regulation; Glutamic Acid; Hum

2014
No quiet surrender: molecular guardians in multiple sclerosis brain.
    The Journal of clinical investigation, 2015, Volume: 125, Issue:4

    Topics: alpha-Crystallin B Chain; Amyloid; Anti-Inflammatory Agents; Antioxidants; Brain; Cytokines; Female;

2015
Alterations of amino acid metabolism in osteoarthritis: its implications for nutrition and health.
    Amino acids, 2016, Volume: 48, Issue:4

    Topics: Arginine; Creatinine; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Homoarginine; Humans; Hydro

2016
Inhibiting neuroinflammation: The role and therapeutic potential of GABA in neuro-immune interactions.
    Brain, behavior, and immunity, 2016, Volume: 54

    Topics: Animals; Anti-Inflammatory Agents; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Humans;

2016
Common Mechanisms Underlying Epileptogenesis and the Comorbidities of Epilepsy.
    Cold Spring Harbor perspectives in medicine, 2016, 07-01, Volume: 6, Issue:7

    Topics: Animals; Brain; Comorbidity; Depression; Epilepsy; gamma-Aminobutyric Acid; Glutamic Acid; Humans; H

2016
Neuropharmacological efficacy of the traditional Japanese Kampo medicine yokukansan and its active ingredients.
    Pharmacology & therapeutics, 2016, Volume: 166

    Topics: Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Catecholamines; Dementia; Drugs, Chinese Herbal

2016
Neuropathology of mood disorders: do we see the stigmata of inflammation?
    Translational psychiatry, 2016, 11-08, Volume: 6, Issue:11

    Topics: Astrocytes; Autoimmune Diseases of the Nervous System; Bipolar Disorder; Brain; Depressive Disorder,

2016
Cytokines and brain excitability.
    Frontiers in neuroendocrinology, 2012, Volume: 33, Issue:1

    Topics: Akathisia, Drug-Induced; Animals; Brain; Cytokines; Down-Regulation; Epilepsy; gamma-Aminobutyric Ac

2012
Predicted role of secretin and oxytocin in the treatment of behavioral and developmental disorders: implications for autism.
    International review of neurobiology, 2005, Volume: 71

    Topics: Autistic Disorder; Behavior; Child; Developmental Disabilities; gamma-Aminobutyric Acid; Humans; Inf

2005
Is metabolic syndrome X a disorder of the brain with the initiation of low-grade systemic inflammatory events during the perinatal period?
    The Journal of nutritional biochemistry, 2007, Volume: 18, Issue:11

    Topics: Animals; Appetite Regulation; Arachidonic Acid; Brain; Diabetes Mellitus, Type 2; Docosahexaenoic Ac

2007
Neuronal damage accompanies perinatal white-matter damage.
    Trends in neurosciences, 2007, Volume: 30, Issue:9

    Topics: Animals; Brain Damage, Chronic; Cerebral Cortex; Excitatory Amino Acids; gamma-Aminobutyric Acid; Gl

2007
Loss of glycinergic and GABAergic inhibition in chronic pain--contributions of inflammation and microglia.
    International immunopharmacology, 2008, Volume: 8, Issue:2

    Topics: Animals; Chronic Disease; Dinoprostone; gamma-Aminobutyric Acid; Glycine; Humans; Inflammation; Micr

2008

Trials

2 trials available for gamma-aminobutyric acid and Innate Inflammatory Response

ArticleYear
Antibiotics and the developing intestinal microbiome, metabolome and inflammatory environment in a randomized trial of preterm infants.
    Scientific reports, 2021, 01-21, Volume: 11, Issue:1

    Topics: Anti-Bacterial Agents; Dysbiosis; Feces; Female; gamma-Aminobutyric Acid; Gastrointestinal Microbiom

2021
The effects of remifentanil and gabapentin on hyperalgesia in a new extended inflammatory skin pain model in healthy volunteers.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:2

    Topics: Acetates; Adult; Amines; Analgesics, Opioid; Cross-Over Studies; Cyclohexanecarboxylic Acids; Diazep

2004

Other Studies

119 other studies available for gamma-aminobutyric acid and Innate Inflammatory Response

ArticleYear
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
    Current protocols in cytometry, 2010, Volume: Chapter 13

    Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr

2010
B cell-derived GABA elicits IL-10
    Nature, 2021, Volume: 599, Issue:7885

    Topics: Animals; B-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Proliferation; Female; gamma-Aminobutyric A

2021
Protective Effect of Gamma Aminobutyric Acid against Aggravation of Renal Injury Caused by High Salt Intake in Cisplatin-Induced Nephrotoxicity.
    International journal of molecular sciences, 2022, Jan-03, Volume: 23, Issue:1

    Topics: Acute Kidney Injury; Animals; Apoptosis; Cisplatin; gamma-Aminobutyric Acid; Inflammation; Kidney; M

2022
Neonatal inflammation via persistent TGF-β1 downregulation decreases GABA
    Neurobiology of disease, 2022, Volume: 169

    Topics: Animals; Animals, Newborn; Anxiety Disorders; Basolateral Nuclear Complex; Down-Regulation; gamma-Am

2022
FKBP51 mediates resilience to inflammation-induced anxiety through regulation of glutamic acid decarboxylase 65 expression in mouse hippocampus.
    Journal of neuroinflammation, 2022, Jun-15, Volume: 19, Issue:1

    Topics: Animals; Anxiety; gamma-Aminobutyric Acid; Glucocorticoids; Glutamate Decarboxylase; Hippocampus; Hu

2022
Transcriptomic analysis supports collective endometrial cell migration in the pathogenesis of adenomyosis.
    Reproductive biomedicine online, 2022, Volume: 45, Issue:3

    Topics: Adenomyosis; Cell Movement; Endometriosis; Endometrium; Female; gamma-Aminobutyric Acid; Humans; Inf

2022
Golexanolone, a GABA
    CNS neuroscience & therapeutics, 2022, Volume: 28, Issue:11

    Topics: Animals; Cognition; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glutaminase; Hyperammonemi

2022
Severe inflammation in new-borns induces long-term cognitive impairment by activation of IL-1β/KCC2 signaling during early development.
    BMC medicine, 2022, 07-27, Volume: 20, Issue:1

    Topics: Animals; Cognitive Dysfunction; gamma-Aminobutyric Acid; Hippocampus; Inflammation; Interleukin-1bet

2022
Pre-Synaptic GABA
    Cells, 2022, 08-03, Volume: 11, Issue:15

    Topics: Animals; Freund's Adjuvant; gamma-Aminobutyric Acid; Hyperalgesia; Inflammation; Mice; Nociceptors

2022
Inhibiting peripheral and central MAO-B ameliorates joint inflammation and cognitive impairment in rheumatoid arthritis.
    Experimental & molecular medicine, 2022, Volume: 54, Issue:8

    Topics: Animals; Arthritis, Rheumatoid; Cells, Cultured; Cognitive Dysfunction; Fibroblasts; gamma-Aminobuty

2022
GAB functions as a bioenergetic and signalling gatekeeper to control T cell inflammation.
    Nature metabolism, 2022, Volume: 4, Issue:10

    Topics: 4-Aminobutyrate Transaminase; Aminobutyrates; Animals; Anti-Inflammatory Agents; Carbon; Encephalomy

2022
Effect of Subthalamic Stimulation and Electrode Implantation in the Striatal Microenvironment in a Parkinson's Disease Rat Model.
    International journal of molecular sciences, 2022, Oct-11, Volume: 23, Issue:20

    Topics: Amino Acid Transport Systems; Animals; Cytokines; Deep Brain Stimulation; Electrodes; gamma-Aminobut

2022
Rice Germ Ameliorated Chronic Unpredictable Mild Stress-Induced Depressive-like Behavior by Reducing Neuroinflammation.
    Nutrients, 2022, Dec-18, Volume: 14, Issue:24

    Topics: Animals; Antidepressive Agents; Caspases; Depression; Disease Models, Animal; gamma-Aminobutyric Aci

2022
Gamma-amino butyric acid (GABA) supplementation alleviates dexamethasone treatment-induced oxidative stress and inflammation response in broiler chickens.
    Stress (Amsterdam, Netherlands), 2023, Volume: 26, Issue:1

    Topics: Animals; Antioxidants; Chickens; Dexamethasone; Diet; Dietary Supplements; gamma-Aminobutyric Acid;

2023
Depletion of microglia with PLX3397 attenuates MK-801-induced hyperactivity associated with regulating inflammation-related genes in the brain.
    Zoological research, 2023, May-18, Volume: 44, Issue:3

    Topics: Animals; Brain; Dizocilpine Maleate; gamma-Aminobutyric Acid; Inflammation; Membrane Glycoproteins;

2023
Monoacylglycerol Lipase Protects the Presynaptic Cannabinoid 1 Receptor from Desensitization by Endocannabinoids after Persistent Inflammation.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023, 07-26, Volume: 43, Issue:30

    Topics: Animals; Cannabinoids; Endocannabinoids; Female; gamma-Aminobutyric Acid; Inflammation; Male; Monoac

2023
Activation of GABA receptor attenuates intestinal inflammation by modulating enteric glial cells function through inhibiting NF-κB pathway.
    Life sciences, 2023, Sep-15, Volume: 329

    Topics: Animals; gamma-Aminobutyric Acid; Inflammation; Lipopolysaccharides; Mice; Neuroglia; NF-kappa B; Re

2023
Herb pair of Polygala tenuifolia Willd and Acorus tatarinowii Schott decoction attenuates seizures and alleviates anxiety in mice: Evidence for modulating inflammation, alleviating oxidative stress and mediating GABA pathway.
    Pakistan journal of pharmaceutical sciences, 2023, Volume: 36, Issue:2

    Topics: Acorus; Animals; Anticonvulsants; Anxiety; Epilepsy; gamma-Aminobutyric Acid; Inflammation; Mice; Ox

2023
Role of astrocytic GABAergic system on inflammatory cytokine-induced anxiety-like behavior.
    Neuropharmacology, 2019, 12-01, Volume: 160

    Topics: Animals; Anxiety; Astrocytes; Behavior, Animal; Cytokines; GABAergic Neurons; gamma-Aminobutyric Aci

2019
Depression, GABA, and Age Correlate with Plasma Levels of Inflammatory Markers.
    International journal of molecular sciences, 2019, Dec-06, Volume: 20, Issue:24

    Topics: Adult; Age Factors; Aged; Biomarkers; Depression; Depressive Disorder, Major; Female; gamma-Aminobut

2019
Vitamin D deficiency induces the excitation/inhibition brain imbalance and the proinflammatory shift.
    The international journal of biochemistry & cell biology, 2020, Volume: 119

    Topics: Animals; Brain; Cholecalciferol; Cholesterol; Disease Models, Animal; gamma-Aminobutyric Acid; Gluta

2020
Exenatide, a GLP-1 analog, has healing effects on LPS-induced autism model: Inflammation, oxidative stress, gliosis, cerebral GABA, and serotonin interactions.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2020, Volume: 80, Issue:7

    Topics: Animals; Autistic Disorder; Cerebral Cortex; Exenatide; Female; gamma-Aminobutyric Acid; Inflammatio

2020
Catatonia in a hospitalized patient with COVID-19 and proposed immune-mediated mechanism.
    Brain, behavior, and immunity, 2020, Volume: 89

    Topics: Aged; Atrial Fibrillation; Basal Ganglia; Betacoronavirus; C-Reactive Protein; Catatonia; Coronaviru

2020
Monocyte chemotactic protein-inducing protein 1 negatively regulating asthmatic airway inflammation and mucus hypersecretion involving γ-aminobutyric acid type A receptor signaling pathway in vivo and in vitro.
    Chinese medical journal, 2020, Sep-30, Volume: 134, Issue:1

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; gamma-Aminobutyric Acid; Inflammation; Mice; Mice, In

2020
Protective Role of Low Ethanol Administration Following Ischemic Stroke via Recovery of KCC2 and p75
    Molecular neurobiology, 2021, Volume: 58, Issue:3

    Topics: Animals; Apoptosis; Biological Transport; Biomarkers; Brain Infarction; Cell Survival; Chlorides; Di

2021
GABA-mediated activated microglia induce neuroinflammation in the hippocampus of mice following cold exposure through the NLRP3 inflammasome and NF-κB signaling pathways.
    International immunopharmacology, 2020, Volume: 89, Issue:Pt B

    Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cold Temperature; Cold-Shock Response; Cytokines; Dise

2020
Antinociceptive effect of intrathecal P7C3 via GABA in a rat model of inflammatory pain.
    European journal of pharmacology, 2021, May-15, Volume: 899

    Topics: Analgesics; Animals; Calcium Signaling; Carbazoles; Disease Models, Animal; Formaldehyde; gamma-Amin

2021
Orthopedic surgery-induced cognitive dysfunction is mediated by CX3CL1/R1 signaling.
    Journal of neuroinflammation, 2021, Apr-15, Volume: 18, Issue:1

    Topics: Animals; Astrocytes; Chemokine CX3CL1; CX3C Chemokine Receptor 1; Disease Models, Animal; gamma-Amin

2021
Early Functional Impairment in Experimental Glaucoma Is Accompanied by Disruption of the GABAergic System and Inceptive Neuroinflammation.
    International journal of molecular sciences, 2021, Jul-15, Volume: 22, Issue:14

    Topics: Animals; Cytoskeletal Proteins; Disease Models, Animal; Eye Proteins; Female; GABAergic Neurons; gam

2021
Increasing extracellular cGMP in cerebellum in vivo reduces neuroinflammation, GABAergic tone and motor in-coordination in hyperammonemic rats.
    Brain, behavior, and immunity, 2018, Volume: 69

    Topics: Animals; Astrocytes; Bicuculline; Cerebellum; Cyclic GMP; GABA-A Receptor Antagonists; gamma-Aminobu

2018
Stabilized Low-n Amyloid-β Oligomers Induce Robust Novel Object Recognition Deficits Associated with Inflammatory, Synaptic, and GABAergic Dysfunction in the Rat.
    Journal of Alzheimer's disease : JAD, 2018, Volume: 62, Issue:1

    Topics: Amyloid beta-Peptides; Animals; Brain; Cognition; Disease Models, Animal; Donepezil; Female; gamma-A

2018
GABA and GABA-Alanine from the Red Microalgae Rhodosorus marinus Exhibit a Significant Neuro-Soothing Activity through Inhibition of Neuro-Inflammation Mediators and Positive Regulation of TRPV1-Related Skin Sensitization.
    Marine drugs, 2018, Mar-17, Volume: 16, Issue:3

    Topics: Alanine; Cells, Cultured; gamma-Aminobutyric Acid; Humans; Inflammation; Inflammation Mediators; Int

2018
Peripheral GABA
    Neuropharmacology, 2018, Volume: 135

    Topics: Animals; Antibodies; Freund's Adjuvant; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma

2018
Effects of chronic noise exposure on the microbiome-gut-brain axis in senescence-accelerated prone mice: implications for Alzheimer's disease.
    Journal of neuroinflammation, 2018, Jun-22, Volume: 15, Issue:1

    Topics: Aging; Animals; Avoidance Learning; Brain; Claudins; Cognition Disorders; Corticosterone; Cytokines;

2018
Acute inflammation sensitizes knee-innervating sensory neurons and decreases mouse digging behavior in a TRPV1-dependent manner.
    Neuropharmacology, 2018, Volume: 143

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Capsaicin; Cells, Cultured; Disease Mo

2018
Exploratory metabolomics of nascent metabolic syndrome.
    Journal of diabetes and its complications, 2019, Volume: 33, Issue:3

    Topics: Adult; Aged; Biomarkers; Blood Glucose; Blood Pressure; Cardiovascular Diseases; Female; gamma-Amino

2019
Immunological and Neurometabolite Changes Associated With Switch From Efavirenz to an Integrase Inhibitor.
    Journal of acquired immune deficiency syndromes (1999), 2019, 08-15, Volume: 81, Issue:5

    Topics: Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Biomarkers; Boston; Central Nervous System; Cycloprop

2019
Enhanced GABAergic Immunoreactivity in Hippocampal Neurons and Astroglia of Multiple Sclerosis Patients.
    Journal of neuropathology and experimental neurology, 2019, 06-01, Volume: 78, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Astrocytes; Demyelinating Diseases; Female; gamma-Aminobutyric Acid;

2019
Role of microRNA-155 in modifying neuroinflammation and γ-aminobutyric acid transporters in specific central regions after post-ischaemic seizures.
    Journal of cellular and molecular medicine, 2019, Volume: 23, Issue:8

    Topics: Amygdala; Animals; Brain Ischemia; Disease Models, Animal; Epilepsy; GABA Plasma Membrane Transport

2019
GABA-stimulated adipose-derived stem cells suppress subcutaneous adipose inflammation in obesity.
    Proceedings of the National Academy of Sciences of the United States of America, 2019, 06-11, Volume: 116, Issue:24

    Topics: Adipocytes; Adipose Tissue; Adiposity; Animals; Diet, High-Fat; Female; gamma-Aminobutyric Acid; Hum

2019
Succinate is an inflammatory signal that induces IL-1β through HIF-1α.
    Nature, 2013, Apr-11, Volume: 496, Issue:7444

    Topics: Animals; Bone Marrow Cells; Citric Acid Cycle; Deoxyglucose; Down-Regulation; gamma-Aminobutyric Aci

2013
Antiallodynic and analgesic effects of maslinic acid, a pentacyclic triterpenoid from Olea europaea.
    Journal of natural products, 2013, Apr-26, Volume: 76, Issue:4

    Topics: Analgesics; Animals; Capsaicin; gamma-Aminobutyric Acid; Hyperalgesia; Inflammation; Mice; Molecular

2013
Cortical GluK1 kainate receptors modulate scratching in adult mice.
    Journal of neurochemistry, 2013, Volume: 126, Issue:5

    Topics: Animals; Antipruritics; Cerebral Cortex; Electrophysiological Phenomena; gamma-Aminobutyric Acid; Ge

2013
Synergistic effects of celecoxib and bupropion in a model of chronic inflammation-related depression in mice.
    PloS one, 2013, Volume: 8, Issue:9

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antidepressive Agents; Behavior, Animal; Brain-Derive

2013
Activity-dependent hyperpolarization of EGABA is absent in cutaneous DRG neurons from inflamed rats.
    Neuroscience, 2014, Jan-03, Volume: 256

    Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Action Potentials; Amino Acids; Animals; Bumetanid

2014
Oral gabapentin treatment accentuates nerve and peripheral inflammatory responses following experimental nerve constriction in Wistar rats.
    Neuroscience letters, 2013, Nov-27, Volume: 556

    Topics: Administration, Oral; Amines; Analgesics; Animals; Cell Movement; Constriction, Pathologic; Cyclohex

2013
Glia and epilepsy: experimental investigation of antiepileptic drugs in an astroglia/microglia co-culture model of inflammation.
    Epilepsia, 2014, Volume: 55, Issue:1

    Topics: Amines; Animals; Anticonvulsants; Astrocytes; Blotting, Western; Carbamazepine; Cells, Cultured; Coc

2014
Gabapentin, a synthetic analogue of gamma aminobutyric acid, reverses systemic acute inflammation and oxidative stress in mice.
    Inflammation, 2014, Volume: 37, Issue:5

    Topics: Acute Disease; Amines; Animals; Anti-Inflammatory Agents; Cyclohexanecarboxylic Acids; Edema; Gabape

2014
Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesis.
    Human molecular genetics, 2014, Dec-15, Volume: 23, Issue:24

    Topics: AMP-Activated Protein Kinases; Animals; DNA-Binding Proteins; Doublecortin Domain Proteins; Electron

2014
Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesis.
    Human molecular genetics, 2014, Dec-15, Volume: 23, Issue:24

    Topics: AMP-Activated Protein Kinases; Animals; DNA-Binding Proteins; Doublecortin Domain Proteins; Electron

2014
Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesis.
    Human molecular genetics, 2014, Dec-15, Volume: 23, Issue:24

    Topics: AMP-Activated Protein Kinases; Animals; DNA-Binding Proteins; Doublecortin Domain Proteins; Electron

2014
Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesis.
    Human molecular genetics, 2014, Dec-15, Volume: 23, Issue:24

    Topics: AMP-Activated Protein Kinases; Animals; DNA-Binding Proteins; Doublecortin Domain Proteins; Electron

2014
Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesis.
    Human molecular genetics, 2014, Dec-15, Volume: 23, Issue:24

    Topics: AMP-Activated Protein Kinases; Animals; DNA-Binding Proteins; Doublecortin Domain Proteins; Electron

2014
Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesis.
    Human molecular genetics, 2014, Dec-15, Volume: 23, Issue:24

    Topics: AMP-Activated Protein Kinases; Animals; DNA-Binding Proteins; Doublecortin Domain Proteins; Electron

2014
Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesis.
    Human molecular genetics, 2014, Dec-15, Volume: 23, Issue:24

    Topics: AMP-Activated Protein Kinases; Animals; DNA-Binding Proteins; Doublecortin Domain Proteins; Electron

2014
Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesis.
    Human molecular genetics, 2014, Dec-15, Volume: 23, Issue:24

    Topics: AMP-Activated Protein Kinases; Animals; DNA-Binding Proteins; Doublecortin Domain Proteins; Electron

2014
Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesis.
    Human molecular genetics, 2014, Dec-15, Volume: 23, Issue:24

    Topics: AMP-Activated Protein Kinases; Animals; DNA-Binding Proteins; Doublecortin Domain Proteins; Electron

2014
Tiagabine improves hippocampal long-term depression in rat pups subjected to prenatal inflammation.
    PloS one, 2014, Volume: 9, Issue:9

    Topics: Animals; Child Development Disorders, Pervasive; Female; GABAergic Neurons; gamma-Aminobutyric Acid;

2014
GABAergic/glutamatergic imbalance relative to excessive neuroinflammation in autism spectrum disorders.
    Journal of neuroinflammation, 2014, Nov-19, Volume: 11

    Topics: Adolescent; Animals; Autism Spectrum Disorder; Biomarkers; Child; Child, Preschool; Female; gamma-Am

2014
BDNF-trkB-KCC2-GABA pathway may be related to chronic stress-induced hyperalgesia at both the spinal and supraspinal level.
    Medical hypotheses, 2014, Volume: 83, Issue:6

    Topics: Animals; Brain-Derived Neurotrophic Factor; gamma-Aminobutyric Acid; Gene Expression Regulation; Hum

2014
In vitro anti-inflammatory properties of fermented pepino (Solanum muricatum) milk by γ-aminobutyric acid-producing Lactobacillus brevis and an in vivo animal model for evaluating its effects on hypertension.
    Journal of the science of food and agriculture, 2016, Jan-15, Volume: 96, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Blood Pressure; Disease Models, Animal; Fermentation; Fruit; Func

2016
In vivo two-photon imaging of structural dynamics in the spinal dorsal horn in an inflammatory pain model.
    The European journal of neuroscience, 2015, Volume: 41, Issue:7

    Topics: Acute Disease; Amines; Animals; Calcium Channel Blockers; Calcium Channels; Cyclohexanecarboxylic Ac

2015
Brainstem brain-derived neurotrophic factor signaling is required for histone deacetylase inhibitor-induced pain relief.
    Molecular pharmacology, 2015, Volume: 87, Issue:6

    Topics: Analgesics; Animals; Brain-Derived Neurotrophic Factor; Carbazoles; gamma-Aminobutyric Acid; Glutama

2015
Inflammation Increases Neuronal Sensitivity to General Anesthetics.
    Anesthesiology, 2016, Volume: 124, Issue:2

    Topics: Anesthetics, General; Anesthetics, Inhalation; Animals; Cells, Cultured; Cerebral Cortex; Etomidate;

2016
Pharmacological characterization of intraplantar Complete Freund's Adjuvant-induced burrowing deficits.
    Behavioural brain research, 2016, Mar-15, Volume: 301

    Topics: Amines; Analgesics; Animals; Antibodies; Behavior, Animal; Celecoxib; Cyclohexanecarboxylic Acids; D

2016
Sex Differences in GABAA Signaling in the Periaqueductal Gray Induced by Persistent Inflammation.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016, Feb-03, Volume: 36, Issue:5

    Topics: Animals; Chronic Pain; Dose-Response Relationship, Drug; Female; GABA Agonists; gamma-Aminobutyric A

2016
Age-associated metabolic dysregulation in bone marrow-derived macrophages stimulated with lipopolysaccharide.
    Scientific reports, 2016, Mar-04, Volume: 6

    Topics: Aging; Animals; Arginine; Cells, Cultured; gamma-Aminobutyric Acid; Glycolysis; Inflammation; Lipopo

2016
Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia.
    Journal of neuroinflammation, 2016, Apr-18, Volume: 13, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Blotting, Western; Cell Membrane; Cerebellum; Disease Models, Ani

2016
Infliximab reduces peripheral inflammation, neuroinflammation, and extracellular GABA in the cerebellum and improves learning and motor coordination in rats with hepatic encephalopathy.
    Journal of neuroinflammation, 2016, 09-13, Volume: 13, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Cerebellum; Cyclic GMP; Cytokines; Dinoprostone; Disease Models,

2016
Vendor-derived differences in injury-induced pain phenotype and pharmacology of Sprague-Dawley rats: Does it matter?
    European journal of pain (London, England), 2017, Volume: 21, Issue:4

    Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Freund's Adjuvant; Gabapentin; gamma-Amino

2017
sec-Butylpropylacetamide (SPD), a new amide derivative of valproic acid for the treatment of neuropathic and inflammatory pain.
    Pharmacological research, 2017, Volume: 117

    Topics: Amides; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin

2017
Inhibition Mediated by Glycinergic and GABAergic Receptors on Excitatory Neurons in Mouse Superficial Dorsal Horn Is Location-Specific but Modified by Inflammation.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017, 03-01, Volume: 37, Issue:9

    Topics: Animals; Animals, Newborn; Disease Models, Animal; Freund's Adjuvant; gamma-Aminobutyric Acid; Glyci

2017
Reduced GABAergic transmission in the ventrobasal thalamus contributes to thermal hyperalgesia in chronic inflammatory pain.
    Scientific reports, 2017, 02-02, Volume: 7

    Topics: Animals; Chronic Pain; Extracellular Space; Freund's Adjuvant; GABAergic Neurons; gamma-Aminobutyric

2017
Immunological alteration & toxic molecular inductions leading to cognitive impairment & neurotoxicity in transgenic mouse model of Alzheimer's disease.
    Life sciences, 2017, May-15, Volume: 177

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Cognition D

2017
Pregabalin and gabapentin inhibit substance P-induced NF-kappaB activation in neuroblastoma and glioma cells.
    Journal of cellular biochemistry, 2008, Oct-01, Volume: 105, Issue:2

    Topics: Amines; Animals; Cell Line, Tumor; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid;

2008
Antihyperalgesic effect of systemic dexmedetomidine and gabapentin in a rat model of monoarthritis.
    Brain research, 2009, Apr-06, Volume: 1264

    Topics: Adjuvants, Immunologic; Amines; Analgesics; Analysis of Variance; Animals; Ankle Joint; Arthritis, E

2009
Gamma-aminobutyric acid amides of nortriptyline and fluoxetine display improved pain suppressing activity.
    Journal of medicinal chemistry, 2009, May-14, Volume: 52, Issue:9

    Topics: Analgesics; Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Fluoxetine; Formaldehyde; gam

2009
Transcriptome profiling reveals TGF-beta signaling involvement in epileptogenesis.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, Jul-15, Volume: 29, Issue:28

    Topics: Action Potentials; Albumins; Animals; Antibodies; Astrocytes; Benzamides; Blood-Brain Barrier; Brain

2009
Abnormal gait, due to inflammation but not nerve injury, reflects enhanced nociception in preclinical pain models.
    Brain research, 2009, Oct-27, Volume: 1295

    Topics: Amines; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Axotomy; Carrageenan;

2009
Inhibitory role for GABA in autoimmune inflammation.
    Proceedings of the National Academy of Sciences of the United States of America, 2010, Feb-09, Volume: 107, Issue:6

    Topics: 4-Aminobutyrate Transaminase; Animals; Antigen-Presenting Cells; Blotting, Western; Cells, Cultured;

2010
A novel CC-chemokine receptor 3 antagonist, Ki19003, inhibits airway eosinophilia and subepithelial/peribronchial fibrosis induced by repeated antigen challenge in mice.
    Journal of pharmacological sciences, 2010, Volume: 112, Issue:2

    Topics: Airway Remodeling; Animals; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Dose-Respo

2010
Chemical composition and evaluation of the anti-hypernociceptive effect of the essential oil extracted from the leaves of Ugni myricoides on inflammatory and neuropathic models of pain in mice.
    Planta medica, 2010, Volume: 76, Issue:13

    Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Bicyclic Monoterpenes; Carr

2010
Studies of synergy between morphine and a novel sodium channel blocker, CNSB002, in rat models of inflammatory and neuropathic pain.
    Pain medicine (Malden, Mass.), 2010, Volume: 11, Issue:1

    Topics: Amines; Analgesics, Opioid; Animals; Carrageenan; Cyclohexanecarboxylic Acids; Diabetes Mellitus, Ex

2010
[Formalin-induced pain stimulation induced expression of GABA in the distal cerebrospinal fluid contacting neurons].
    Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 2010, Volume: 26, Issue:1

    Topics: Animals; Brain; Cerebrospinal Fluid; Formaldehyde; gamma-Aminobutyric Acid; Inflammation; Male; Neur

2010
Role of NKCC1 and KCC2 in the development of chronic neuropathic pain following spinal cord injury.
    Annals of the New York Academy of Sciences, 2010, Volume: 1198

    Topics: Animals; Bumetanide; Chronic Disease; gamma-Aminobutyric Acid; Hyperalgesia; Inflammation; K Cl- Cot

2010
Dissociation of rewarding, anti-aversive and anti-nociceptive effects of different classes of anti-nociceptives in the rat.
    European journal of pain (London, England), 2011, Volume: 15, Issue:3

    Topics: Analgesics; Animals; Carrageenan; Conditioning, Psychological; Dose-Response Relationship, Drug; gam

2011
Pregabalin as a neuroprotector after spinal cord injury in rats: biochemical analysis and effect on glial cells.
    Journal of Korean medical science, 2011, Volume: 26, Issue:3

    Topics: Animals; Apoptosis; Astrocytes; Blotting, Western; Body Weight; Caspase 3; Cell Proliferation; Fluor

2011
Metabotropic glutamate receptor subtype 8 in the amygdala modulates thermal threshold, neurotransmitter release, and rostral ventromedial medulla cell activity in inflammatory pain.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Mar-23, Volume: 31, Issue:12

    Topics: Amino Acids; Amygdala; Animals; Behavior, Animal; Benzoates; Blotting, Western; Carrageenan; Chromat

2011
The MAO inhibitor phenelzine improves functional outcomes in mice with experimental autoimmune encephalomyelitis (EAE).
    Brain, behavior, and immunity, 2011, Volume: 25, Issue:8

    Topics: Affect; Animals; Anterior Horn Cells; Brain Chemistry; Chromatography, High Pressure Liquid; Disease

2011
Oral treatment with γ-aminobutyric acid improves glucose tolerance and insulin sensitivity by inhibiting inflammation in high fat diet-fed mice.
    PloS one, 2011, Volume: 6, Issue:9

    Topics: Administration, Oral; Animals; CD4-Positive T-Lymphocytes; Diabetes Mellitus, Type 2; Diet, High-Fat

2011
Spontaneous burrowing behaviour in the rat is reduced by peripheral nerve injury or inflammation associated pain.
    European journal of pain (London, England), 2012, Volume: 16, Issue:4

    Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Cyclohexanec

2012
Inflammatory mediators potentiate high affinity GABA(A) currents in rat dorsal root ganglion neurons.
    Neuroscience letters, 2012, Jun-19, Volume: 518, Issue:2

    Topics: Action Potentials; Animals; Bradykinin; Dinoprostone; gamma-Aminobutyric Acid; Ganglia, Spinal; Hist

2012
Systemic pregabalin attenuates sensorimotor responses and medullary glutamate release in inflammatory tooth pain model.
    Neuroscience, 2012, Aug-30, Volume: 218

    Topics: Analgesics; Animals; Dental Pulp; Disease Models, Animal; Electromyography; Facial Muscles; gamma-Am

2012
Effects of anesthetic regimes on inflammatory responses in a rat model of acute lung injury.
    Intensive care medicine, 2012, Volume: 38, Issue:9

    Topics: Acute Lung Injury; Analysis of Variance; Anesthesia; Anesthetics, Dissociative; Anesthetics, General

2012
Persistent inflammation increases GABA-induced depolarization of rat cutaneous dorsal root ganglion neurons in vitro.
    Neuroscience, 2012, Sep-18, Volume: 220

    Topics: Animals; Blotting, Western; gamma-Aminobutyric Acid; Ganglia, Spinal; Hyperalgesia; Inflammation; Ma

2012
Systemic treatment with the inhibitory neurotransmitter γ-aminobutyric acid aggravates experimental autoimmune encephalomyelitis by affecting proinflammatory immune responses.
    Journal of neuroimmunology, 2013, Feb-15, Volume: 255, Issue:1-2

    Topics: Animals; Encephalomyelitis, Autoimmune, Experimental; Female; GABA Agents; gamma-Aminobutyric Acid;

2013
Diets enriched in foods with high antioxidant activity reverse age-induced decreases in cerebellar beta-adrenergic function and increases in proinflammatory cytokines.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, Jul-15, Volume: 22, Issue:14

    Topics: Aging; Animals; Antioxidants; Bacterial Proteins; Cerebellum; Cucumis sativus; Cytokines; Dietary Su

2002
Expression of 5-HT1A receptor mRNA in rat lumbar spinal dorsal horn neurons after peripheral inflammation.
    Pain, 2002, Volume: 98, Issue:3

    Topics: Animals; Enkephalins; gamma-Aminobutyric Acid; Inflammation; Lumbosacral Region; Male; Peripheral Ne

2002
Anti-allodynic action of the tormentic acid, a triterpene isolated from plant, against neuropathic and inflammatory persistent pain in mice.
    European journal of pharmacology, 2002, Oct-25, Volume: 453, Issue:2-3

    Topics: Acetates; Amines; Analgesics; Animals; Chronic Disease; Cyclohexanecarboxylic Acids; Female; Freund'

2002
Gabapentin reduces the mechanosensitivity of fine afferent nerve fibres in normal and inflamed rat knee joints.
    Pain, 2003, Volume: 104, Issue:1-2

    Topics: Acetates; Amines; Animals; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Gabapentin

2003
Pregabalin and gabapentin reduce release of substance P and CGRP from rat spinal tissues only after inflammation or activation of protein kinase C.
    Pain, 2003, Volume: 105, Issue:1-2

    Topics: Acetates; Amines; Analgesics; Animals; Calcitonin Gene-Related Peptide; Cyclohexanecarboxylic Acids;

2003
Anti-allodynic and anti-oedematogenic properties of the extract and lignans from Phyllanthus amarus in models of persistent inflammatory and neuropathic pain.
    European journal of pharmacology, 2003, Oct-08, Volume: 478, Issue:2-3

    Topics: Acetates; Amines; Analgesics; Animals; Anti-Inflammatory Agents; Cyclohexanecarboxylic Acids; Edema;

2003
Differential release of neurotransmitters from superficial and deep layers of the dorsal horn in response to acute noxious stimulation and inflammation of the rat paw.
    European journal of pain (London, England), 2004, Volume: 8, Issue:3

    Topics: Afferent Pathways; Animals; Arginine; Aspartic Acid; Chondrus; Extracellular Fluid; Foot; gamma-Amin

2004
Evidence that GABAergic neurons in the spinal trigeminal nucleus are involved in the transmission of inflammatory pain in the rat: a microdialysis and pharmacological study.
    European journal of pharmacology, 2004, Aug-02, Volume: 496, Issue:1-3

    Topics: Animals; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Inflammation; Male; Microdialysis

2004
Gamma-aminobutyric acid inhibits T cell autoimmunity and the development of inflammatory responses in a mouse type 1 diabetes model.
    Journal of immunology (Baltimore, Md. : 1950), 2004, Oct-15, Volume: 173, Issue:8

    Topics: Adoptive Transfer; Animals; Autoimmunity; CD4-Positive T-Lymphocytes; Cell Cycle; Diabetes Mellitus,

2004
Efficacy of duloxetine, a potent and balanced serotonergic and noradrenergic reuptake inhibitor, in inflammatory and acute pain models in rodents.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 312, Issue:2

    Topics: Adrenergic Uptake Inhibitors; Amines; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Age

2005
Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy.
    Neuropharmacology, 2005, Volume: 48, Issue:5

    Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anxiety; Ataxia; Behavior, Ani

2005
Detection of the inhibitory neurotransmitter GABA in macrophages by magnetic resonance spectroscopy.
    Journal of leukocyte biology, 2005, Volume: 78, Issue:2

    Topics: Amino Acids; Animals; Biomarkers; Brain Injuries; Cell Communication; Cell Extracts; Cell Line; Cell

2005
Ambroxol, a Nav1.8-preferring Na(+) channel blocker, effectively suppresses pain symptoms in animal models of chronic, neuropathic and inflammatory pain.
    Neuropharmacology, 2005, Volume: 49, Issue:8

    Topics: Ambroxol; Amines; Analgesics; Animals; Behavior, Animal; Constriction, Pathologic; Cyclohexanecarbox

2005
The effects of diacerhein on mechanical allodynia in inflammatory and neuropathic models of nociception in mice.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:6

    Topics: Amines; Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Cyclohexanecarboxylic Acid

2005
A spinal muscarinic M2 receptor-GABAergic disinhibition pathway that modulates peripheral inflammation in mice.
    Neuropharmacology, 2007, Volume: 53, Issue:5

    Topics: Adrenal Cortex Hormones; Adrenal Glands; Animals; Anti-Inflammatory Agents; Autonomic Fibers, Pregan

2007
CD4(+)CD25(-) effector T-cells inhibit hippocampal long-term potentiation in vitro.
    The European journal of neuroscience, 2007, Volume: 26, Issue:6

    Topics: Animals; CD4-Positive T-Lymphocytes; Cytokines; Electric Stimulation; Electrophysiology; GABA Antago

2007
Nuclear factor-kappaB decoy amelioration of spinal cord injury-induced inflammation and behavior outcomes.
    Journal of neuroscience research, 2008, Feb-15, Volume: 86, Issue:3

    Topics: Animals; Behavior, Animal; Binding Sites; Cyclooxygenase 2; DNA; Enzyme Inhibitors; gamma-Aminobutyr

2008
Gene expression profile analysis of epilepsy-associated gangliogliomas.
    Neuroscience, 2008, Jan-02, Volume: 151, Issue:1

    Topics: Adult; Brain Neoplasms; Cell Adhesion; Complement System Proteins; DNA Primers; Epilepsy; Extracellu

2008
Pregabalin as a neuroprotector after spinal cord injury in rats.
    European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2008, Volume: 17, Issue:6

    Topics: Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Apoptosis; gamma-Aminobutyric

2008
Carrageenan-induced inflammation of the hind foot provokes a rise of GABA-immunoreactive cells in the rat spinal cord that is prevented by peripheral neurectomy or neonatal capsaicin treatment.
    Pain, 1994, Volume: 56, Issue:2

    Topics: Animals; Animals, Newborn; Capsaicin; Carrageenan; Denervation; Female; Foot; gamma-Aminobutyric Aci

1994
Gabapentin, ineffective in normal rats, markedly reduces C-fibre evoked responses after inflammation.
    Neuroreport, 1997, Feb-10, Volume: 8, Issue:3

    Topics: Acetates; Afferent Pathways; Amines; Analgesics; Animals; Carrageenan; Cyclohexanecarboxylic Acids;

1997
Central modulation of formalin-induced acute peripheral inflammation & pain by some putative amino acid neurotransmitters in rats.
    The Indian journal of medical research, 1998, Volume: 108

    Topics: Acute Disease; Amino Acids; Animals; Aspartic Acid; Brain; Formaldehyde; gamma-Aminobutyric Acid; In

1998
Peripheral inflammation is associated with decreased veratridine-induced release of GABA in the rat ventrocaudal periaqueductal gray: microdialysis study.
    Journal of the neurological sciences, 1999, Mar-01, Volume: 163, Issue:2

    Topics: Animals; Chromatography, High Pressure Liquid; gamma-Aminobutyric Acid; Inflammation; Male; Microdia

1999
Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia.
    Nature, 2000, May-11, Volume: 405, Issue:6783

    Topics: Adenosine Triphosphate; Animals; Arachidonic Acids; Behavior, Animal; Capsaicin; Carrageenan; Cells,

2000
Traumatic brain injury alters the molecular fingerprint of TUNEL-positive cortical neurons In vivo: A single-cell analysis.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Jul-01, Volume: 20, Issue:13

    Topics: Animals; Apoptosis; Brain Injuries; Caspase 2; Caspases; Cell Death; Cerebral Cortex; Cyclic AMP Res

2000
The effects of GABA(B) agonists and gabapentin on mechanical hyperalgesia in models of neuropathic and inflammatory pain in the rat.
    Pain, 2001, Feb-15, Volume: 90, Issue:3

    Topics: Acetates; Amines; Analgesics; Animals; Baclofen; Cyclohexanecarboxylic Acids; Electric Stimulation;

2001
NMDA or non-NMDA receptor antagonists attenuate increased Fos expression in spinal dorsal horn GABAergic neurons after intradermal injection of capsaicin in rats.
    Neuroscience, 2001, Volume: 106, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Blotting, Western; Capsa

2001
Spinal GABA(B)-receptor antagonism increases nociceptive transmission in vivo.
    Neuroreport, 2001, Oct-29, Volume: 12, Issue:15

    Topics: Action Potentials; Animals; Carrageenan; Dose-Response Relationship, Drug; Electric Stimulation; GAB

2001
Age-dependent changes in 24-hour rhythms of thymic and circulating growth hormone and adrenocorticotropin in rats injected with Freund's adjuvant.
    Neuroimmunomodulation, 2001, Volume: 9, Issue:5

    Topics: Adrenocorticotropic Hormone; Aging; Animals; Aspartic Acid; Behavior, Animal; Chronobiology Disorder

2001
Gabapentin potentiates N-methyl-D-aspartate receptor mediated currents in rat GABAergic dorsal horn neurons.
    Neuroscience letters, 2002, May-24, Volume: 324, Issue:3

    Topics: Acetates; Afferent Pathways; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Fluorescent D

2002
Classification and mechanism of migraine.
    Headache, 1979, Volume: 19, Issue:3

    Topics: Diet; Estradiol Congeners; Fatty Acids, Nonesterified; Female; gamma-Aminobutyric Acid; Humans; Hype

1979