gamma-aminobutyric acid has been researched along with Hyperammonemia in 17 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
Hyperammonemia: Elevated level of AMMONIA in the blood. It is a sign of defective CATABOLISM of AMINO ACIDS or ammonia to UREA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study was to investigate the effects of ammonia and manganese in the metabolism of minimal hepatic encephalopathy (MHE)." | 8.31 | The interaction of ammonia and manganese in abnormal metabolism of minimal hepatic encephalopathy: A comparison metabolomics study. ( Li, Y; Liu, XF; Lu, JJ; Qiang, JW; Yang, XY, 2023) |
| " Sulforaphane could be a new therapeutic approach to improve cognitive and motor function in hyperammonemia, hepatic encephalopathy, and other pathologies associated with neuroinflammation by promoting microglia differentiation from M1 to M2." | 7.83 | Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia. ( Agusti, A; Balzano, T; Cabrera-Pastor, A; Felipo, V; Gonzalez-Usano, A; Hernandez-Rabaza, V; Llansola, M; Taoro-Gonzalez, L, 2016) |
| "Sulforaphane promotes polarization of microglia from the M1 to the M2 phenotype, reducing IL-1b and increasing IL-4, IL-10, Arg1, and YM-1 in the cerebellum." | 5.43 | Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia. ( Agusti, A; Balzano, T; Cabrera-Pastor, A; Felipo, V; Gonzalez-Usano, A; Hernandez-Rabaza, V; Llansola, M; Taoro-Gonzalez, L, 2016) |
| "Hyperammonemia is a major etiological toxic factor in the development of hepatic encephalopathy." | 5.39 | Brain alanine formation as an ammonia-scavenging pathway during hyperammonemia: effects of glutamine synthetase inhibition in rats and astrocyte-neuron co-cultures. ( Bak, LK; Dadsetan, S; Keiding, S; Kukolj, E; Ott, P; Schousboe, A; Sørensen, M; Vilstrup, H; Waagepetersen, HS, 2013) |
| "This study was to investigate the effects of ammonia and manganese in the metabolism of minimal hepatic encephalopathy (MHE)." | 4.31 | The interaction of ammonia and manganese in abnormal metabolism of minimal hepatic encephalopathy: A comparison metabolomics study. ( Li, Y; Liu, XF; Lu, JJ; Qiang, JW; Yang, XY, 2023) |
| "Rats were treated with golexanolone and effects on peripheral inflammation, neuroinflammation, TNFR1-glutaminase-GAT3 and TNFR1-CCL2-TrkB-KCC2 pathways, and cognitive and motor function were analyzed." | 4.12 | Golexanolone, a GABA ( Bäckström, T; Blackburn, TP; Doverskog, M; Felipo, V; Gimenez-Garzo, C; Hällgren, A; Izquierdo-Altarejos, P; Llansola, M; Martinez-Garcia, M; Mincheva, G, 2022) |
| " This was associated with reversal of the hyperammonemia-enhanced activation in cerebellum of the TNFR1-glutaminase-GAT3 and TNFR1-CCL2-TrkB-KCC2 pathways." | 4.12 | Golexanolone, a GABA ( Bäckström, T; Blackburn, TP; Doverskog, M; Felipo, V; Gimenez-Garzo, C; Hällgren, A; Izquierdo-Altarejos, P; Llansola, M; Martinez-Garcia, M; Mincheva, G, 2022) |
| " Sulforaphane could be a new therapeutic approach to improve cognitive and motor function in hyperammonemia, hepatic encephalopathy, and other pathologies associated with neuroinflammation by promoting microglia differentiation from M1 to M2." | 3.83 | Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia. ( Agusti, A; Balzano, T; Cabrera-Pastor, A; Felipo, V; Gonzalez-Usano, A; Hernandez-Rabaza, V; Llansola, M; Taoro-Gonzalez, L, 2016) |
| "Hyperammonemia is necessary for development of the cerebral complications to liver disease including hepatic encephalopathy and cerebral edema but the mechanisms are unclear." | 2.50 | Cerebral effects of ammonia in liver disease: current hypotheses. ( Ott, P; Vilstrup, H, 2014) |
| "Hyperammonemia is a main contributor to the alterations in neurotransmission and in neurological functions in HE." | 2.45 | Glutamatergic and gabaergic neurotransmission and neuronal circuits in hepatic encephalopathy. ( Agustí, A; Boix, J; Cauli, O; El Mlili, N; Felipo, V; Llansola, M; Monfort, P; Montoliu, C; Piedrafita, B; Rodrigo, R, 2009) |
| "Patients with hepatic encephalopathy (HE) may present different neurological alterations including impaired cognitive function and altered motor activity and coordination." | 2.45 | Glutamatergic and gabaergic neurotransmission and neuronal circuits in hepatic encephalopathy. ( Agustí, A; Boix, J; Cauli, O; El Mlili, N; Felipo, V; Llansola, M; Monfort, P; Montoliu, C; Piedrafita, B; Rodrigo, R, 2009) |
| "Hyperammonemia is a main contributor to minimal hepatic encephalopathy (MHE) in cirrhotic patients." | 1.72 | Enhanced BDNF and TrkB Activation Enhance GABA Neurotransmission in Cerebellum in Hyperammonemia. ( Arenas, YM; Felipo, V; Llansola, M; Martínez-García, M, 2022) |
| "Chronic hyperammonemia is a common condition affecting individuals with inherited urea cycle disorders resulting in progressive cognitive impairment and behavioral abnormalities." | 1.56 | Chronic hyperammonemia causes a hypoglutamatergic and hyperGABAergic metabolic state associated with neurobehavioral abnormalities in zebrafish larvae. ( Gursky, E; Hoffmann, GF; Kölker, S; Kumar, A; Okun, JG; Peravali, R; Posset, R; Probst, J; Zielonka, M, 2020) |
| "Hyperammonemia is a main contributor to cognitive impairment and motor in-coordination in patients with hepatic encephalopathy." | 1.48 | Increasing extracellular cGMP in cerebellum in vivo reduces neuroinflammation, GABAergic tone and motor in-coordination in hyperammonemic rats. ( Balzano, T; Cabrera-Pastor, A; Felipo, V; Hernández-Rabaza, V; Llansola, M; Malaguarnera, M, 2018) |
| "Sulforaphane promotes polarization of microglia from the M1 to the M2 phenotype, reducing IL-1b and increasing IL-4, IL-10, Arg1, and YM-1 in the cerebellum." | 1.43 | Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia. ( Agusti, A; Balzano, T; Cabrera-Pastor, A; Felipo, V; Gonzalez-Usano, A; Hernandez-Rabaza, V; Llansola, M; Taoro-Gonzalez, L, 2016) |
| "Hyperammonemia is a major etiological toxic factor in the development of hepatic encephalopathy." | 1.39 | Brain alanine formation as an ammonia-scavenging pathway during hyperammonemia: effects of glutamine synthetase inhibition in rats and astrocyte-neuron co-cultures. ( Bak, LK; Dadsetan, S; Keiding, S; Kukolj, E; Ott, P; Schousboe, A; Sørensen, M; Vilstrup, H; Waagepetersen, HS, 2013) |
| "However, hyperammonemia-induced convulsions were inhibited by GABA in a dose-dependent manner." | 1.32 | Inhibition of acute hyperammonemia-induced convulsions by systemically administered gamma aminobutyric acid in rats. ( Paul, V, 2003) |
| "A partial but significant inhibition of convulsions was found in these animals." | 1.31 | Evidence for an involvement of the ammonia-decreasing action of L-arginine in suppressing picrotoxin-induced convulsions in rats and its additive action with diazepam. ( Jayakumar, AR; Vanaja, P, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (29.41) | 29.6817 |
| 2010's | 7 (41.18) | 24.3611 |
| 2020's | 5 (29.41) | 2.80 |
| Authors | Studies |
|---|---|
| Sancho-Alonso, M | 1 |
| Garcia-Garcia, R | 1 |
| Teruel-Martí, V | 1 |
| Llansola, M | 6 |
| Felipo, V | 7 |
| Mincheva, G | 1 |
| Gimenez-Garzo, C | 1 |
| Izquierdo-Altarejos, P | 1 |
| Martinez-Garcia, M | 2 |
| Doverskog, M | 1 |
| Blackburn, TP | 1 |
| Hällgren, A | 1 |
| Bäckström, T | 1 |
| Arenas, YM | 2 |
| Liu, XF | 1 |
| Lu, JJ | 1 |
| Li, Y | 1 |
| Yang, XY | 1 |
| Qiang, JW | 1 |
| Probst, J | 1 |
| Kölker, S | 1 |
| Okun, JG | 1 |
| Kumar, A | 1 |
| Gursky, E | 1 |
| Posset, R | 1 |
| Hoffmann, GF | 1 |
| Peravali, R | 1 |
| Zielonka, M | 1 |
| Cabrera-Pastor, A | 3 |
| Balzano, T | 2 |
| Hernández-Rabaza, V | 2 |
| Malaguarnera, M | 1 |
| Taoro-Gonzalez, L | 2 |
| Montoliu, C | 2 |
| Dadsetan, S | 1 |
| Kukolj, E | 1 |
| Bak, LK | 2 |
| Sørensen, M | 1 |
| Ott, P | 2 |
| Vilstrup, H | 2 |
| Schousboe, A | 2 |
| Keiding, S | 1 |
| Waagepetersen, HS | 2 |
| Leke, R | 1 |
| Gonzalez-Usano, A | 1 |
| Agusti, A | 2 |
| Cauli, O | 1 |
| Rodrigo, R | 1 |
| Monfort, P | 1 |
| Piedrafita, B | 1 |
| El Mlili, N | 1 |
| Boix, J | 1 |
| Izumi, Y | 1 |
| Svrakic, N | 1 |
| O'Dell, K | 1 |
| Zorumski, CF | 1 |
| Paul, V | 1 |
| Behar, KL | 1 |
| Rothman, DL | 1 |
| Vanaja, P | 1 |
| Jayakumar, AR | 1 |
| Irie, T | 1 |
| Miyamoto, E | 1 |
| Kitagawa, K | 1 |
| Maruyama, Y | 1 |
| Inoue, K | 1 |
| Inagaki, C | 1 |
5 reviews available for gamma-aminobutyric acid and Hyperammonemia
| Article | Year |
|---|---|
Chronic hyperammonemia alters extracellular glutamate, glutamine and GABA and membrane expression of their transporters in rat cerebellum. Modulation by extracellular cGMP.
Topics: Animals; Cell Membrane; Cerebellum; Citrulline; Cyclic GMP; Extracellular Space; gamma-Aminobutyric | 2019 |
Cerebral effects of ammonia in liver disease: current hypotheses.
Topics: Ammonia; Animals; Astrocytes; Blood-Brain Barrier; Brain Edema; Diffusion; Energy Metabolism; gamma- | 2014 |
Effects of hyperammonemia on brain energy metabolism: controversial findings in vivo and in vitro.
Topics: Animals; Astrocytes; Brain; Cells, Cultured; Energy Metabolism; GABAergic Neurons; gamma-Aminobutyri | 2014 |
Glutamatergic and gabaergic neurotransmission and neuronal circuits in hepatic encephalopathy.
Topics: Animals; Brain; gamma-Aminobutyric Acid; Glutamic Acid; Hepatic Encephalopathy; Humans; Hyperammonem | 2009 |
In vivo nuclear magnetic resonance studies of glutamate-gamma-aminobutyric acid-glutamine cycling in rodent and human cortex: the central role of glutamine.
Topics: Acetates; Animals; Astrocytes; Biological Transport; Blood-Brain Barrier; Carbon Isotopes; Cerebral | 2001 |
12 other studies available for gamma-aminobutyric acid and Hyperammonemia
| Article | Year |
|---|---|
Hyperammonemia Enhances GABAergic Neurotransmission in Hippocampus: Underlying Mechanisms and Modulation by Extracellular cGMP.
Topics: Animals; Cyclic GMP; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Hepatic Encep | 2022 |
Golexanolone, a GABA
Topics: Animals; Cognition; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glutaminase; Hyperammonemi | 2022 |
Enhanced BDNF and TrkB Activation Enhance GABA Neurotransmission in Cerebellum in Hyperammonemia.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cerebellum; Chlorides; gamma-Aminobutyric Acid; Hepatic | 2022 |
The interaction of ammonia and manganese in abnormal metabolism of minimal hepatic encephalopathy: A comparison metabolomics study.
Topics: Alanine; Ammonia; Animals; Arginine; Brain; Citrulline; gamma-Aminobutyric Acid; Glutamic Acid; Glut | 2023 |
Chronic hyperammonemia causes a hypoglutamatergic and hyperGABAergic metabolic state associated with neurobehavioral abnormalities in zebrafish larvae.
Topics: Animals; Behavior, Animal; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Hyperammo | 2020 |
Increasing extracellular cGMP in cerebellum in vivo reduces neuroinflammation, GABAergic tone and motor in-coordination in hyperammonemic rats.
Topics: Animals; Astrocytes; Bicuculline; Cerebellum; Cyclic GMP; GABA-A Receptor Antagonists; gamma-Aminobu | 2018 |
Brain alanine formation as an ammonia-scavenging pathway during hyperammonemia: effects of glutamine synthetase inhibition in rats and astrocyte-neuron co-cultures.
Topics: Alanine; Amino Acids; Ammonia; Animals; Astrocytes; Brain Chemistry; Chromatography, High Pressure L | 2013 |
Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia.
Topics: Animals; Anti-Inflammatory Agents; Blotting, Western; Cell Membrane; Cerebellum; Disease Models, Ani | 2016 |
Ammonia inhibits long-term potentiation via neurosteroid synthesis in hippocampal pyramidal neurons.
Topics: Adaptation, Physiological; Ammonia; Animals; CA1 Region, Hippocampal; Cognition; gamma-Aminobutyric | 2013 |
Inhibition of acute hyperammonemia-induced convulsions by systemically administered gamma aminobutyric acid in rats.
Topics: Ammonia; Animals; Brain; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Hyperammonemia; | 2003 |
Evidence for an involvement of the ammonia-decreasing action of L-arginine in suppressing picrotoxin-induced convulsions in rats and its additive action with diazepam.
Topics: Ammonia; Animals; Arginine; Brain; Diazepam; Drug Interactions; Epilepsy; GABA Antagonists; GABA Mod | 2001 |
An anxiolytic agent, dihydrohonokiol-B, inhibits ammonia-induced increases in the intracellular Cl(-) of cultured rat hippocampal neurons via GABA(c) receptors.
Topics: Ammonia; Ammonium Chloride; Animals; Anti-Anxiety Agents; Biphenyl Compounds; Chlorides; Dose-Respon | 2001 |