gamma-aminobutyric acid has been researched along with Hemangiosarcoma in 3 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
Hemangiosarcoma: A rare malignant neoplasm characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and lining irregular blood-filled or lumpy spaces. (Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pregabalin increased the incidence of hemangiosarcomas in carcinogenicity studies of 2-year mice but was not tumorigenic in rats." | 7.78 | Mode of action associated with development of hemangiosarcoma in mice given pregabalin and assessment of human relevance. ( Anderson, T; Brady, JT; Cook, JC; Criswell, KA; Giddings, J; Herman, J; Pegg, D; Wesche, D; Wojcinski, Z, 2012) |
| "In carcinogenicity studies, pregabalin increased hemangiosarcoma incidence in mice but not in rats." | 7.78 | Key components of the mode of action for hemangiosarcoma induction in pregabalin-treated mice: evidence of increased bicarbonate, dysregulated erythropoiesis, macrophage activation, and increased angiogenic growth factors in mice but not in rats. ( Albassam, M; Anderson, T; Bailie, M; Criswell, KA; Duddy, S; Foote, S; Olsen, E; Pegg, D; Wojcinski, Z, 2012) |
| "Pregabalin increased the incidence of hemangiosarcomas in carcinogenicity studies of 2-year mice but was not tumorigenic in rats." | 3.78 | Mode of action associated with development of hemangiosarcoma in mice given pregabalin and assessment of human relevance. ( Anderson, T; Brady, JT; Cook, JC; Criswell, KA; Giddings, J; Herman, J; Pegg, D; Wesche, D; Wojcinski, Z, 2012) |
| "In carcinogenicity studies, pregabalin increased hemangiosarcoma incidence in mice but not in rats." | 3.78 | Key components of the mode of action for hemangiosarcoma induction in pregabalin-treated mice: evidence of increased bicarbonate, dysregulated erythropoiesis, macrophage activation, and increased angiogenic growth factors in mice but not in rats. ( Albassam, M; Anderson, T; Bailie, M; Criswell, KA; Duddy, S; Foote, S; Olsen, E; Pegg, D; Wojcinski, Z, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pegg, D | 3 |
| Bleavins, M | 1 |
| Herman, J | 2 |
| Wojcinski, Z | 3 |
| Graziano, M | 1 |
| Henck, J | 1 |
| Criswell, KA | 3 |
| Anderson, T | 3 |
| Duddy, S | 2 |
| Cook, JC | 1 |
| Wesche, D | 1 |
| Giddings, J | 1 |
| Brady, JT | 1 |
| Albassam, M | 1 |
| Olsen, E | 1 |
| Bailie, M | 1 |
| Foote, S | 1 |
3 other studies available for gamma-aminobutyric acid and Hemangiosarcoma
| Article | Year |
|---|---|
Hemangiosarcoma in mice administered pregabalin: analysis of genotoxicity, tumor incidence, and tumor genetics.
Topics: Animals; Carcinogenicity Tests; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Genes, p5 | 2012 |
Mode of action associated with development of hemangiosarcoma in mice given pregabalin and assessment of human relevance.
Topics: Animals; Cell Proliferation; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Hemangiosarc | 2012 |
Key components of the mode of action for hemangiosarcoma induction in pregabalin-treated mice: evidence of increased bicarbonate, dysregulated erythropoiesis, macrophage activation, and increased angiogenic growth factors in mice but not in rats.
Topics: Animals; Bicarbonates; Blood Gas Analysis; Erythropoiesis; Female; Fibroblast Growth Factor 2; gamma | 2012 |