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gamma-aminobutyric acid and HIV Coinfection

gamma-aminobutyric acid has been researched along with HIV Coinfection in 16 studies

gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.

Research Excerpts

ExcerptRelevanceReference
"The objective of this study was to assess the efficacy and safety of Gabapentin as the sole analgesic in patients with HIV-related painful neuropathy."7.71Gabapentin in painful HIV-related neuropathy: a report of 19 patients, preliminary observations. ( Bottura, P; La Spina, I; Maggiolo, F; Porazzi, D; Suter, F, 2001)
"Neuropathic pain is commonly associated with affective disorders such as anxiety and depression."5.35Anxiety-like behaviour is attenuated by gabapentin, morphine and diazepam in a rodent model of HIV anti-retroviral-associated neuropathic pain. ( Blackbeard, J; Pheby, T; Rice, AS; Segerdahl, AR; Wallace, VC, 2008)
" Two distinct FAAH inhibitory compounds, URB597 and PF-3845 were tested, and contrasted with standard antinociceptive gabapentin or vehicle treatment, for attenuation of tactile allodynia, cold allodynia, and mechanical hyperalgesia."3.81Attenuation of persistent pain-related behavior by fatty acid amide hydrolase (FAAH) inhibitors in a rat model of HIV sensory neuropathy. ( Jergova, S; Nasirinezhad, F; Pearson, JP; Sagen, J, 2015)
"The objective of this study was to assess the efficacy and safety of Gabapentin as the sole analgesic in patients with HIV-related painful neuropathy."3.71Gabapentin in painful HIV-related neuropathy: a report of 19 patients, preliminary observations. ( Bottura, P; La Spina, I; Maggiolo, F; Porazzi, D; Suter, F, 2001)
" Pregabalin average daily dosage (SD) was 385."2.75Pregabalin for painful HIV neuropathy: a randomized, double-blind, placebo-controlled trial. ( Clifford, DB; Durso-De Cruz, E; Emir, B; Freeman, R; Glue, P; Murphy, TK; Schifitto, G; Scott, GN; Simpson, DM; Whalen, E, 2010)
"Pregabalin is effective in several neuropathic pain syndromes."2.75Pregabalin for painful HIV neuropathy: a randomized, double-blind, placebo-controlled trial. ( Clifford, DB; Durso-De Cruz, E; Emir, B; Freeman, R; Glue, P; Murphy, TK; Schifitto, G; Scott, GN; Simpson, DM; Whalen, E, 2010)
"Treatment with gabapentin, but not amitriptyline, was associated with a complete attenuation of hind paw mechanical hypersensitivity observed with indinavir treatment."1.46A rodent model of HIV protease inhibitor indinavir induced peripheral neuropathy. ( Bennett, DLH; Calvo, M; Huang, W; Pheby, T; Rice, ASC, 2017)
"It often presents with significant neuropathic pain and is associated with previous exposure to neurotoxic nucleoside reverse transcriptase inhibitors."1.46A rodent model of HIV protease inhibitor indinavir induced peripheral neuropathy. ( Bennett, DLH; Calvo, M; Huang, W; Pheby, T; Rice, ASC, 2017)
" In this study, we tested the hypothesis that HIV gp120 combined with antiretroviral therapy reduces spinal GABAergic inhibitory tone and that restoration of GABAergic inhibitory tone will reduce HIV-related NP in a rat model."1.42Gene Transfer of Glutamic Acid Decarboxylase 67 by Herpes Simplex Virus Vectors Suppresses Neuropathic Pain Induced by Human Immunodeficiency Virus gp120 Combined with ddC in Rats. ( Candiotti, KA; Hao, S; Huang, W; Kanao, M; Kanda, H; Levitt, RC; Liu, S; Lubarsky, DA; Yi, H, 2015)
"Spinal epidural lipomatosis is a rare condition of adipose tissue hypertrophy in the epidural space."1.38Epidural lipomatosis causing new debilitating back pain in a patient with human immunodeficiency virus on highly active antiretroviral therapy. ( Billings, F; Hoyt, MR, 2012)
"Epidural lipomatosis was diagnosed by magnetic resonance imaging."1.38Epidural lipomatosis causing new debilitating back pain in a patient with human immunodeficiency virus on highly active antiretroviral therapy. ( Billings, F; Hoyt, MR, 2012)
"Neuropathic pain is commonly associated with affective disorders such as anxiety and depression."1.35Anxiety-like behaviour is attenuated by gabapentin, morphine and diazepam in a rodent model of HIV anti-retroviral-associated neuropathic pain. ( Blackbeard, J; Pheby, T; Rice, AS; Segerdahl, AR; Wallace, VC, 2008)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (31.25)18.2507
2000's4 (25.00)29.6817
2010's7 (43.75)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Asundi, A1
Robles, Y1
Starr, T1
Landay, A1
Kinslow, J1
Ladner, J1
White, L1
Plank, RM1
Melbourne, K1
Weisholtz, D1
Bennett, M1
Pan, H1
Stern, E1
Lin, A1
Kuritzkes, DR1
Lin, NH1
Nasirinezhad, F1
Jergova, S1
Pearson, JP1
Sagen, J1
Kanao, M1
Kanda, H1
Huang, W2
Liu, S1
Yi, H1
Candiotti, KA1
Lubarsky, DA1
Levitt, RC1
Hao, S1
Calvo, M1
Pheby, T2
Bennett, DLH1
Rice, ASC1
Wallace, VC1
Segerdahl, AR1
Blackbeard, J1
Rice, AS1
Terbach, N1
Williams, RS1
Simpson, DM1
Schifitto, G1
Clifford, DB1
Murphy, TK1
Durso-De Cruz, E1
Glue, P1
Whalen, E1
Emir, B1
Scott, GN1
Freeman, R1
Wiersinga, WJ1
Prins, JM1
van de Beek, D1
Billings, F1
Hoyt, MR1
Banakar, S1
Thomas, MA1
Deveikis, A1
Watzl, JQ1
Hayes, J1
Keller, MA1
Skolnick, AA1
Manack, L1
Rosner, H1
Rubin, L1
Kestenbaum, A1
Newshan, G1
Vadivelu, N1
Berger, J1
Peña, D1
Prada, JL1
de La Torre, J1
del Arco, A1
García-Alegría, J1
La Spina, I1
Porazzi, D1
Maggiolo, F1
Bottura, P1
Suter, F1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Persistent Postoperative Pain Incidence With Long Term Perioperative Gabapentin Used[NCT02693821]Phase 4122 participants (Actual)Interventional2015-12-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for gamma-aminobutyric acid and HIV Coinfection

ArticleYear
Structure-function studies for the panacea, valproic acid.
    Biochemical Society transactions, 2009, Volume: 37, Issue:Pt 5

    Topics: Animals; Anticonvulsants; Bipolar Disorder; Epilepsy; gamma-Aminobutyric Acid; Glycogen Synthase Kin

2009
[Gabapentin in the treatment of polyneuropathy associated with the human immunodeficiency virus].
    Enfermedades infecciosas y microbiologia clinica, 1999, Volume: 17, Issue:10

    Topics: Acetates; Adult; Amines; Cyclohexanecarboxylic Acids; GABA Agonists; Gabapentin; gamma-Aminobutyric

1999

Trials

2 trials available for gamma-aminobutyric acid and HIV Coinfection

ArticleYear
Pregabalin for painful HIV neuropathy: a randomized, double-blind, placebo-controlled trial.
    Neurology, 2010, Feb-02, Volume: 74, Issue:5

    Topics: Adult; Analgesics; Analysis of Variance; Double-Blind Method; Female; Follow-Up Studies; gamma-Amino

2010
Gabapentin adjunctive therapy in neuropathic pain states.
    The Clinical journal of pain, 1996, Volume: 12, Issue:1

    Topics: Acetates; Adult; Aged; Amines; Analgesics; Cyclohexanecarboxylic Acids; Facial Pain; Female; Gabapen

1996

Other Studies

12 other studies available for gamma-aminobutyric acid and HIV Coinfection

ArticleYear
Immunological and Neurometabolite Changes Associated With Switch From Efavirenz to an Integrase Inhibitor.
    Journal of acquired immune deficiency syndromes (1999), 2019, 08-15, Volume: 81, Issue:5

    Topics: Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Biomarkers; Boston; Central Nervous System; Cycloprop

2019
Attenuation of persistent pain-related behavior by fatty acid amide hydrolase (FAAH) inhibitors in a rat model of HIV sensory neuropathy.
    Neuropharmacology, 2015, Volume: 95

    Topics: Amidohydrolases; Amines; Analgesics; Animals; Benzamides; Carbamates; Cyclohexanecarboxylic Acids; D

2015
Gene Transfer of Glutamic Acid Decarboxylase 67 by Herpes Simplex Virus Vectors Suppresses Neuropathic Pain Induced by Human Immunodeficiency Virus gp120 Combined with ddC in Rats.
    Anesthesia and analgesia, 2015, Volume: 120, Issue:6

    Topics: Animals; CCAAT-Enhancer-Binding Protein-beta; Cyclic AMP Response Element-Binding Protein; Decarboxy

2015
A rodent model of HIV protease inhibitor indinavir induced peripheral neuropathy.
    Pain, 2017, Volume: 158, Issue:1

    Topics: Amines; Analgesics; Animals; Calcitonin Gene-Related Peptide; Calcium-Binding Proteins; Cyclohexanec

2017
Anxiety-like behaviour is attenuated by gabapentin, morphine and diazepam in a rodent model of HIV anti-retroviral-associated neuropathic pain.
    Neuroscience letters, 2008, Dec-19, Volume: 448, Issue:1

    Topics: Amines; Analgesics; Animal Diseases; Animals; Anxiety; Behavior, Animal; Cyclohexanecarboxylic Acids

2008
Therapy-resistant opsoclonus-myoclonus syndrome secondary to HIV-1 infection.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2012, Feb-01, Volume: 54, Issue:3

    Topics: Adult; Amines; Anti-HIV Agents; Anti-Inflammatory Agents; Cyclohexanecarboxylic Acids; Excitatory Am

2012
Epidural lipomatosis causing new debilitating back pain in a patient with human immunodeficiency virus on highly active antiretroviral therapy.
    International journal of obstetric anesthesia, 2012, Volume: 21, Issue:4

    Topics: Adult; Amines; Analgesics; Analgesics, Opioid; Anesthetics, Intravenous; Anti-Inflammatory Agents, N

2012
Two-dimensional 1H MR spectroscopy of the brain in human immunodeficiency virus (HIV)-infected children.
    Journal of magnetic resonance imaging : JMRI, 2008, Volume: 27, Issue:4

    Topics: Adolescent; Adult; Aspartic Acid; Brain; Child; Choline; Creatine; gamma-Aminobutyric Acid; HIV Infe

2008
Science reporters hear wide range of recent data at 12th annual conference.
    JAMA, 1993, Nov-24, Volume: 270, Issue:20

    Topics: Acetates; Aged; AIDS Vaccines; American Medical Association; Amines; Animals; Anticonvulsants; beta-

1993
HIV neuropathy treated with gabapentin.
    AIDS (London, England), 1998, Jan-22, Volume: 12, Issue:2

    Topics: Acetates; Adult; Amines; Analgesics; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Aci

1998
Neuropathic pain after anti-HIV gene therapy successfully treated with gabapentin.
    Journal of pain and symptom management, 1999, Volume: 17, Issue:3

    Topics: Acetates; Adult; Amines; Analgesics; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Aci

1999
Gabapentin in painful HIV-related neuropathy: a report of 19 patients, preliminary observations.
    European journal of neurology, 2001, Volume: 8, Issue:1

    Topics: Acetates; Adult; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Ami

2001