gamma-aminobutyric acid has been researched along with Glaucoma in 14 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
Glaucoma: An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We explored the melatonin influence on the level of amino acid neurotransmitters of the retina in glaucoma neuropathy in rats." | 7.79 | [Protective action of melatonin in experimental glaucoma in rats]. ( Mykheĭtseva, IM, 2013) |
| "To use gabapentin to relieve discomfort in a painful, blind glaucomatous eye of a patient unwilling to undergo further invasive treatment." | 7.74 | Gabapentin therapy for painful, blind glaucomatous eye: case report. ( Dimou, T; Kavalieratos, CS, 2008) |
| "Gabapentin may relieve pain in a painful, blind, glaucomatous eye." | 7.74 | Gabapentin therapy for painful, blind glaucomatous eye: case report. ( Dimou, T; Kavalieratos, CS, 2008) |
| "Gabapentin is an antiepileptic used for neuropathic pain treatment." | 7.74 | Gabapentin therapy for painful, blind glaucomatous eye: case report. ( Dimou, T; Kavalieratos, CS, 2008) |
| "Patient rated his pregabapentin and postgabapentin pain by a verbal descriptor scale and a numerical scale." | 7.74 | Gabapentin therapy for painful, blind glaucomatous eye: case report. ( Dimou, T; Kavalieratos, CS, 2008) |
| "Gabapentin provided significant pain relief (on a 0-10 scale, reduction from "8" to "0-2") at regular visits over 6 months." | 7.74 | Gabapentin therapy for painful, blind glaucomatous eye: case report. ( Dimou, T; Kavalieratos, CS, 2008) |
| "Glaucoma was caused by the prolong systemic introduction of adrenalin." | 5.39 | [Protective action of melatonin in experimental glaucoma in rats]. ( Mykheĭtseva, IM, 2013) |
| "Glaucoma is a leading cause of blindness." | 5.36 | Melatonin: a novel neuroprotectant for the treatment of glaucoma. ( Belforte, NA; Chianelli, MS; de Zavalía, N; Keller Sarmiento, MI; Moreno, MC; Rosenstein, RE; Sande, PH, 2010) |
| "Gabapentin is an antiepileptic used for neuropathic pain treatment." | 5.35 | Gabapentin therapy for painful, blind glaucomatous eye: case report. ( Dimou, T; Kavalieratos, CS, 2008) |
| " However, the neuroprotective effects and the mechanism of action of PNU-282987, an α7-nAChR agonist, in a chronic in vivo rat glaucoma model are poorly understood." | 3.85 | Alpha7 nicotinic acetylcholine receptor agonist promotes retinal ganglion cell function via modulating GABAergic presynaptic activity in a chronic glaucomatous model. ( Cheng, Y; Li, G; Wu, J; Yang, B; Zhang, R; Zhang, S; Zhou, X, 2017) |
| "We explored the melatonin influence on the level of amino acid neurotransmitters of the retina in glaucoma neuropathy in rats." | 3.79 | [Protective action of melatonin in experimental glaucoma in rats]. ( Mykheĭtseva, IM, 2013) |
| "To use gabapentin to relieve discomfort in a painful, blind glaucomatous eye of a patient unwilling to undergo further invasive treatment." | 3.74 | Gabapentin therapy for painful, blind glaucomatous eye: case report. ( Dimou, T; Kavalieratos, CS, 2008) |
| "Gabapentin may relieve pain in a painful, blind, glaucomatous eye." | 3.74 | Gabapentin therapy for painful, blind glaucomatous eye: case report. ( Dimou, T; Kavalieratos, CS, 2008) |
| "Gabapentin is an antiepileptic used for neuropathic pain treatment." | 3.74 | Gabapentin therapy for painful, blind glaucomatous eye: case report. ( Dimou, T; Kavalieratos, CS, 2008) |
| "Patient rated his pregabapentin and postgabapentin pain by a verbal descriptor scale and a numerical scale." | 3.74 | Gabapentin therapy for painful, blind glaucomatous eye: case report. ( Dimou, T; Kavalieratos, CS, 2008) |
| "Gabapentin provided significant pain relief (on a 0-10 scale, reduction from "8" to "0-2") at regular visits over 6 months." | 3.74 | Gabapentin therapy for painful, blind glaucomatous eye: case report. ( Dimou, T; Kavalieratos, CS, 2008) |
| "Amacrine cells identified by GABA and glycine labeling were not significantly affected by experimental glaucoma, with a mean decrease of 15% compared with bilaterally untreated control cells (557 +/- 186 neurons/mm [glaucoma] versus 653." | 3.73 | The effect of experimental glaucoma and optic nerve transection on amacrine cells in the rat retina. ( Kielczewski, JL; Pease, ME; Quigley, HA, 2005) |
| "An inner retinal component removed by GABA and glycine was found in both the normal and glaucomatous eyes." | 3.72 | Functional damage to inner and outer retinal cells in experimental glaucoma. ( Lambrou, GN; Ofri, R; Percicot, CL; Perlman, I; Raz, D, 2003) |
| "Glaucoma is an age-related neurodegenerative disease of the visual system, affecting both the eye and the brain." | 1.91 | GABA decrease is associated with degraded neural specificity in the visual cortex of glaucoma patients. ( Bang, JW; Chan, KC; Parra, C; Schuman, JS; Wollstein, G; Yu, K, 2023) |
| "Glaucoma is a leading cause of irreversible blindness worldwide, and increased intraocular pressure (IOP) is a major risk factor." | 1.62 | Early Functional Impairment in Experimental Glaucoma Is Accompanied by Disruption of the GABAergic System and Inceptive Neuroinflammation. ( Elwood, BW; Godwin, CR; Gramlich, OW; Kuehn, MH; Wadkins, D, 2021) |
| "Glaucoma was caused by the prolong systemic introduction of adrenalin." | 1.39 | [Protective action of melatonin in experimental glaucoma in rats]. ( Mykheĭtseva, IM, 2013) |
| "Glaucoma is a leading cause of blindness." | 1.36 | Melatonin: a novel neuroprotectant for the treatment of glaucoma. ( Belforte, NA; Chianelli, MS; de Zavalía, N; Keller Sarmiento, MI; Moreno, MC; Rosenstein, RE; Sande, PH, 2010) |
| "Gabapentin is an antiepileptic used for neuropathic pain treatment." | 1.35 | Gabapentin therapy for painful, blind glaucomatous eye: case report. ( Dimou, T; Kavalieratos, CS, 2008) |
| "Complete optic nerve transection was performed unilaterally in nine rats with survival for 1 (n = 4) and 3 (n = 5) months." | 1.33 | The effect of experimental glaucoma and optic nerve transection on amacrine cells in the rat retina. ( Kielczewski, JL; Pease, ME; Quigley, HA, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 7 (50.00) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 2 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Bang, JW | 1 |
| Parra, C | 1 |
| Yu, K | 1 |
| Wollstein, G | 2 |
| Schuman, JS | 2 |
| Chan, KC | 1 |
| Gramlich, OW | 1 |
| Godwin, CR | 1 |
| Wadkins, D | 1 |
| Elwood, BW | 1 |
| Kuehn, MH | 1 |
| Zhou, X | 1 |
| Cheng, Y | 1 |
| Zhang, R | 1 |
| Li, G | 1 |
| Yang, B | 1 |
| Zhang, S | 1 |
| Wu, J | 1 |
| Mykheĭtseva, IM | 1 |
| Bailey, JN | 1 |
| Yaspan, BL | 1 |
| Pasquale, LR | 1 |
| Hauser, MA | 1 |
| Kang, JH | 1 |
| Loomis, SJ | 1 |
| Brilliant, M | 1 |
| Budenz, DL | 1 |
| Christen, WG | 1 |
| Fingert, J | 1 |
| Gaasterland, D | 1 |
| Gaasterland, T | 1 |
| Kraft, P | 1 |
| Lee, RK | 1 |
| Lichter, PR | 1 |
| Liu, Y | 1 |
| McCarty, CA | 1 |
| Moroi, SE | 1 |
| Richards, JE | 1 |
| Realini, T | 1 |
| Scott, WK | 1 |
| Singh, K | 1 |
| Sit, AJ | 1 |
| Vollrath, D | 1 |
| Zack, DJ | 1 |
| Zhang, K | 1 |
| Pericak-Vance, MA | 1 |
| Allingham, RR | 1 |
| Weinreb, RN | 1 |
| Haines, JL | 1 |
| Wiggs, JL | 1 |
| Belforte, NA | 1 |
| Moreno, MC | 1 |
| de Zavalía, N | 1 |
| Sande, PH | 1 |
| Chianelli, MS | 1 |
| Keller Sarmiento, MI | 1 |
| Rosenstein, RE | 1 |
| Raz, D | 1 |
| Perlman, I | 1 |
| Percicot, CL | 1 |
| Lambrou, GN | 1 |
| Ofri, R | 1 |
| Fontana, AC | 2 |
| Guizzo, R | 2 |
| de Oliveira Beleboni, R | 1 |
| Meirelles E Silva, AR | 1 |
| Coimbra, NC | 1 |
| Amara, SG | 1 |
| dos Santos, WF | 2 |
| Coutinho-Netto, J | 2 |
| Kielczewski, JL | 1 |
| Pease, ME | 1 |
| Quigley, HA | 1 |
| Beleboni, RO | 1 |
| Pizzo, AB | 1 |
| Carolino, RO | 1 |
| Gobbo-Neto, L | 1 |
| Lopes, NP | 1 |
| Lascaratos, G | 1 |
| Ji, D | 1 |
| Wood, JP | 1 |
| Osborne, NN | 1 |
| Zhou, W | 1 |
| Rangaswamy, N | 1 |
| Ktonas, P | 1 |
| Frishman, LJ | 1 |
| Kavalieratos, CS | 1 |
| Dimou, T | 1 |
| Mincione, G | 1 |
| Menabuoni, L | 1 |
| Briganti, F | 1 |
| Mincione, F | 1 |
| Scozzafava, A | 1 |
| Supuran, CT | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Oral Gabapentin and Pregabalin in Postoperative Pain Control After Photorefractive Keratectomy: a Prospective, Randomized Study.[NCT00954187] | 8 participants (Actual) | Interventional | 2009-11-30 | Terminated (stopped due to PI left institution) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
14 other studies available for gamma-aminobutyric acid and Glaucoma
| Article | Year |
|---|---|
GABA decrease is associated with degraded neural specificity in the visual cortex of glaucoma patients.
Topics: Aged; Cognition; gamma-Aminobutyric Acid; Glaucoma; Glutamic Acid; Humans; Neurodegenerative Disease | 2023 |
Early Functional Impairment in Experimental Glaucoma Is Accompanied by Disruption of the GABAergic System and Inceptive Neuroinflammation.
Topics: Animals; Cytoskeletal Proteins; Disease Models, Animal; Eye Proteins; Female; GABAergic Neurons; gam | 2021 |
Alpha7 nicotinic acetylcholine receptor agonist promotes retinal ganglion cell function via modulating GABAergic presynaptic activity in a chronic glaucomatous model.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzamides; Bridged Bicyclo Compounds; Cell Surviv | 2017 |
[Protective action of melatonin in experimental glaucoma in rats].
Topics: Animals; Antioxidants; Aspartic Acid; Chromatography, Ion Exchange; Epinephrine; gamma-Aminobutyric | 2013 |
Hypothesis-independent pathway analysis implicates GABA and acetyl-CoA metabolism in primary open-angle glaucoma and normal-pressure glaucoma.
Topics: Acetyl Coenzyme A; Case-Control Studies; Cluster Analysis; Female; gamma-Aminobutyric Acid; Genetic | 2014 |
Melatonin: a novel neuroprotectant for the treatment of glaucoma.
Topics: Animals; Arginine; gamma-Aminobutyric Acid; Glaucoma; Glutamate Decarboxylase; Glutamic Acid; Histoc | 2010 |
Functional damage to inner and outer retinal cells in experimental glaucoma.
Topics: Aminobutyrates; Animals; Electroretinography; gamma-Aminobutyric Acid; Glaucoma; Glycine; Interneuro | 2003 |
Purification of a neuroprotective component of Parawixia bistriata spider venom that enhances glutamate uptake.
Topics: Animals; Brazil; Carbon Isotopes; Cerebral Cortex; Chromatography, High Pressure Liquid; Chromatogra | 2003 |
The effect of experimental glaucoma and optic nerve transection on amacrine cells in the rat retina.
Topics: Amacrine Cells; Animals; Axons; Cell Count; Disease Models, Animal; gamma-Aminobutyric Acid; Glaucom | 2005 |
Neurochemical characterization of a neuroprotective compound from Parawixia bistriata spider venom that inhibits synaptosomal uptake of GABA and glycine.
Topics: Animals; Biological Transport; GABA Plasma Membrane Transport Proteins; GABA-B Receptor Agonists; ga | 2006 |
Visible light affects mitochondrial function and induces neuronal death in retinal cell cultures.
Topics: Animals; Apoptosis; Caspase 3; Cell Survival; Cells, Cultured; DNA Damage; Electrophoresis, Polyacry | 2007 |
Oscillatory potentials of the slow-sequence multifocal ERG in primates extracted using the Matching Pursuit method.
Topics: Animals; Disease Models, Animal; Electroretinography; gamma-Aminobutyric Acid; Glaucoma; Macaca; N-M | 2007 |
Gabapentin therapy for painful, blind glaucomatous eye: case report.
Topics: Aged; Amines; Analgesics; Blindness; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Aci | 2008 |
Carbonic anhydrase inhibitors. Part 79. Synthesis of topically acting sulfonamides incorporating GABA moieties in their molecule, with long-lasting intraocular pressure-lowering properties.
Topics: Administration, Topical; Animals; Carbonic Anhydrase Inhibitors; Cell Membrane; Cornea; Cytosol; Dis | 1999 |