gamma-aminobutyric acid has been researched along with Genetic Predisposition in 104 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The N-methyl-D-aspartate receptor hypofunction model of schizophrenia predicts dysfunction in both glutamatergic and gamma-aminobutyric acidergic (GABAergic) transmission." | 7.85 | 7T Proton Magnetic Resonance Spectroscopy of Gamma-Aminobutyric Acid, Glutamate, and Glutamine Reveals Altered Concentrations in Patients With Schizophrenia and Healthy Siblings. ( Boer, VO; Cahn, W; Kahn, RS; Klomp, DW; Neggers, SF; Rösler, L; Thakkar, KN; Wijnen, JP, 2017) |
| "Pharmacological evidence suggests the involvement of gamma-aminobutyric acid (GABA) perturbation in the etiology of mood disorders." | 7.72 | Evidence of association between gamma-aminobutyric acid type A receptor genes located on 5q34 and female patients with mood disorders. ( Iwayama-Shigeno, Y; Watanabe, A; Yamada, K; Yoshikawa, T, 2003) |
| "The purpose of the present investigation was to determine whether the sensitivity to systemic toxic effects of cocaine is altered in genetically epilepsy-prone rats (GEPRs)." | 7.70 | Phenotypic expression of the systemic toxicity of cocaine in genetically epilepsy-prone rats. ( Heavner, JE; Kao, YJ; Kaye, AD; Reigel, CE; Shi, B, 2000) |
| "Alcohol dependence is associated with time-dependent changes in brain GABA(A) receptor density and subunit gene expression levels that contribute to a withdrawal-related deficit in GABA(A) receptor function." | 6.43 | Gamma-aminobutyric acid type A receptors and alcoholism: intoxication, dependence, vulnerability, and treatment. ( Gelernter, J; Harris, RA; Kaufman, J; Krystal, JH; Lappalainen, J; Mason, G; Petrakis, IL; Staley, J, 2006) |
| "The purpose of the present investigation was to determine whether the sensitivity to systemic toxic effects of cocaine is altered in genetically epilepsy-prone rats (GEPRs)." | 5.31 | Phenotypic expression of the systemic toxicity of cocaine in genetically epilepsy-prone rats. ( Heavner, JE; Kao, YJ; Kaye, AD; Reigel, CE; Shi, B, 2000) |
| "Moderate seizure (GEPR-3) and severe seizure (GEPR-9) rats, and the control strain, Sprague-Dawley rats, 10 weeks of age, were lightly anesthetized with halothane and nitrous oxide." | 5.31 | Phenotypic expression of the systemic toxicity of cocaine in genetically epilepsy-prone rats. ( Heavner, JE; Kao, YJ; Kaye, AD; Reigel, CE; Shi, B, 2000) |
| "The N-methyl-D-aspartate receptor hypofunction model of schizophrenia predicts dysfunction in both glutamatergic and gamma-aminobutyric acidergic (GABAergic) transmission." | 3.85 | 7T Proton Magnetic Resonance Spectroscopy of Gamma-Aminobutyric Acid, Glutamate, and Glutamine Reveals Altered Concentrations in Patients With Schizophrenia and Healthy Siblings. ( Boer, VO; Cahn, W; Kahn, RS; Klomp, DW; Neggers, SF; Rösler, L; Thakkar, KN; Wijnen, JP, 2017) |
| "Involvement of the gamma-aminobutyric acid (GABA)-ergic system in schizophrenia pathogenesis through disrupted neurodevelopment has been highlighted in numerous studies." | 3.85 | Comprehensive association analysis of 27 genes from the GABAergic system in Japanese individuals affected with schizophrenia. ( Balan, S; Hashimoto, T; Iwayama, Y; Kameno, Y; Kanahara, N; Kikuchi, M; Kurita, D; Maekawa, M; Shimamoto, C; Takagai, S; Toyota, T; Wakuda, T; Yamada, K; Yoshikawa, T, 2017) |
| "Proline dehydrogenase (PRODH), which degrades L-proline, resides within the schizophrenia-linked 22q11." | 3.83 | Cytosolic Accumulation of L-Proline Disrupts GABA-Ergic Transmission through GAD Blockade. ( Crabtree, GW; Gogos, JA; Gordon, JA; Park, AJ, 2016) |
| "Clinical features and animal models of essential tremor (ET) suggest gamma-aminobutyric acid A receptor (GABA(A) R) subunits and GABA transporters as putative candidate genes." | 3.77 | GABA(A) receptor- and GABA transporter polymorphisms and risk for essential tremor. ( Christensen, K; Deuschl, G; Klebe, S; Kuhlenbäumer, G; Lorenz, D; Nebel, A; Nothnagel, M; Schreiber, S; Thier, S, 2011) |
| "Recent advances in schizophrenia (SZ) research indicate that the telencephalic gamma-aminobutyric acid (GABA)ergic neurotransmission deficit associated with this psychiatric disorder probably is mediated by the hypermethylation of the glutamic acid decarboxylase 67 (GAD(67)), reelin and other GABAergic promoters." | 3.75 | Characterization of the action of antipsychotic subtypes on valproate-induced chromatin remodeling. ( Costa, E; Dong, E; Grayson, DR; Guidotti, A; Kundakovic, M; Satta, R, 2009) |
| "Pharmacological evidence suggests the involvement of gamma-aminobutyric acid (GABA) perturbation in the etiology of mood disorders." | 3.72 | Evidence of association between gamma-aminobutyric acid type A receptor genes located on 5q34 and female patients with mood disorders. ( Iwayama-Shigeno, Y; Watanabe, A; Yamada, K; Yoshikawa, T, 2003) |
| " In the present study, we used in vivo microdialysis to measure the levels of extracellular GABA (gamma-aminobutyric acid) and glutamate during seizure development in rats with a genetic predisposition for (Fast), or against (Slow), amygdala kindling." | 3.71 | Changes in extracellular levels of amygdala amino acids in genetically fast and slow kindling rat strains. ( Anisman, H; McIntyre, DC; Merali, Z; Shin, RS, 2002) |
| "Considerable evidence implicates the neurotransmitter gamma-aminobutyric acid (GABA) in the biochemical pathophysiology of mood disorders." | 3.70 | GABAA alpha-1 subunit gene not associated with depressive symptomatology in mood disorders. ( Catalano, M; Cusin, C; Di Bella, D; Lattuada, E; Lilli, R; Macciardi, F; Serretti, A; Smeraldi, E, 1998) |
| "The purpose of the present investigation was to determine whether the sensitivity to systemic toxic effects of cocaine is altered in genetically epilepsy-prone rats (GEPRs)." | 3.70 | Phenotypic expression of the systemic toxicity of cocaine in genetically epilepsy-prone rats. ( Heavner, JE; Kao, YJ; Kaye, AD; Reigel, CE; Shi, B, 2000) |
| "Schizophrenia is believed to result from problems during neural development that lead to improper function of synaptic transmission and plasticity, and in agreement, many of the susceptibility genes encode proteins critical for neural development." | 2.48 | Synaptic dysfunction in schizophrenia. ( Chen, YJ; Mei, L; Sathyamurthy, A; Xiong, WC; Yin, DM, 2012) |
| "Genetic predisposition to autism has been demonstrated from families and twin studies." | 2.44 | [Autism, chromosome 15 and the GAbaergic dysfunction hypothesis]. ( Delgado-Luengo, W; Hernández, ML; Solís-Añez, E, 2007) |
| "Autism is a complex neurodevelopmental disorder characterized by impairment of social interaction, language, communication, and stereotyped, repetitive behavior." | 2.44 | [Autism, chromosome 15 and the GAbaergic dysfunction hypothesis]. ( Delgado-Luengo, W; Hernández, ML; Solís-Añez, E, 2007) |
| "Alcohol dependence is associated with time-dependent changes in brain GABA(A) receptor density and subunit gene expression levels that contribute to a withdrawal-related deficit in GABA(A) receptor function." | 2.43 | Gamma-aminobutyric acid type A receptors and alcoholism: intoxication, dependence, vulnerability, and treatment. ( Gelernter, J; Harris, RA; Kaufman, J; Krystal, JH; Lappalainen, J; Mason, G; Petrakis, IL; Staley, J, 2006) |
| "elegans allows our electroconvulsive seizure (ES) assay to be used as a behavioral readout of the locomotor circuit and neuronal function." | 1.62 | O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 modulate seizure susceptibility in C. elegans. ( Dawson-Scully, K; Giles, A; Grill, B; Opperman, KJ; Suthakaran, N; Wiggins, J, 2021) |
| "Children at increased genetic risk for type 1 diabetes (T1D) after environmental exposures may develop pancreatic islet autoantibodies (IA) at a very young age." | 1.56 | Longitudinal Metabolome-Wide Signals Prior to the Appearance of a First Islet Autoantibody in Children Participating in the TEDDY Study. ( Akolkar, B; Butterworth, MD; Fan, S; Fiehn, O; Hagopian, W; Krischer, JP; Lernmark, Å; Li, Q; Parikh, H; Rewers, M; She, JX; Toppari, J; Ziegler, AG, 2020) |
| " Since brain-derived neurotrophic factor (BDNF) promotes GABAergic synaptogenesis, we hypothesized that individual differences in this vulnerability may arise from differences in the link between BDNF bioavailability and FR-evoked wheel running." | 1.46 | Variant BDNF-Val66Met Polymorphism is Associated with Layer-Specific Alterations in GABAergic Innervation of Pyramidal Neurons, Elevated Anxiety and Reduced Vulnerability of Adolescent Male Mice to Activity-Based Anorexia. ( Aoki, C; Chen, YW; Lee, F; Rana, BS; Surgent, O, 2017) |
| "A total of 130 patients with OSAHS and 136 age- and gender-matched healthy controls were enrolled in this study." | 1.43 | Association between Single Nucleotide Polymorphisms in Gamma-Aminobutyric Acid B Receptor, Insulin Receptor Substrate-1, and Hypocretin Neuropeptide Precursor Genes and Susceptibility to Obstructive Sleep Apnea Hypopnea Syndrome in a Chinese Han Populatio ( Du, J; Li, Z; Qin, G; Tang, T; Wu, W; Zhou, X, 2016) |
| " Sixty-nine healthy subjects (21-30 years) underwent a laboratory-based within-session cumulative oral alcohol dosing procedure, achieving a mean peak blood alcohol level of 100." | 1.39 | GABRA2 markers moderate the subjective effects of alcohol. ( Guo, X; Kranzler, HR; Li, N; McCaul, ME; Uhart, M; Wand, GS; Weerts, EM; Yan, X, 2013) |
| "Furthermore, the threshold of seizures induced by pentylenetetrazol was significantly reduced in both heterozygous and null mutants." | 1.35 | Efhc1 deficiency causes spontaneous myoclonus and increased seizure susceptibility. ( Delgado-Escueta, AV; Hensch, TK; Hirota, Y; Inoue, I; Itohara, S; Jiang, B; Miyamoto, H; Nakahari, T; Saido, TC; Sawamoto, K; Suemoto, T; Suzuki, T; Tsumoto, T; Yamakawa, K, 2009) |
| "Rett syndrome is a neurodevelopmental disorder caused by mutations in the transcriptional repressor methyl-CpG-binding protein 2 (MeCP2) and represents the leading genetic cause for mental retardation in girls." | 1.35 | Early defects of GABAergic synapses in the brain stem of a MeCP2 mouse model of Rett syndrome. ( Aramuni, G; Dudanova, I; Medrihan, L; Missler, M; Sargsyan, V; Tantalaki, E; Zhang, W, 2008) |
| "Instead, before kindling, a focal seizure in the Slow rats was associated with a large decrease in GABA in the non-stimulated amygdala, while amino acid levels in the Fast rats remained near baseline in both amygdalae." | 1.31 | Changes in extracellular levels of amygdala amino acids in genetically fast and slow kindling rat strains. ( Anisman, H; McIntyre, DC; Merali, Z; Shin, RS, 2002) |
| "The purpose of the present investigation was to determine whether the sensitivity to systemic toxic effects of cocaine is altered in genetically epilepsy-prone rats (GEPRs)." | 1.31 | Phenotypic expression of the systemic toxicity of cocaine in genetically epilepsy-prone rats. ( Heavner, JE; Kao, YJ; Kaye, AD; Reigel, CE; Shi, B, 2000) |
| "Moderate seizure (GEPR-3) and severe seizure (GEPR-9) rats, and the control strain, Sprague-Dawley rats, 10 weeks of age, were lightly anesthetized with halothane and nitrous oxide." | 1.31 | Phenotypic expression of the systemic toxicity of cocaine in genetically epilepsy-prone rats. ( Heavner, JE; Kao, YJ; Kaye, AD; Reigel, CE; Shi, B, 2000) |
| "Though displaying no spontaneous seizure activity, these mice exhibit altered electroencephalographic patterns and increased susceptibility to seizure induced by kainic acid." | 1.31 | Overexpression of gamma-aminobutyric acid transporter subtype I leads to susceptibility to kainic acid-induced seizure in transgenic mice. ( Fei, J; Guo, LH; Hu, JH; Ma, Y; Mei, ZT; Yu, Y; Zhao, WJ; Zhou, XG, 2001) |
| "gamma-Aminobutyric acid (GABA) is a major neurotransmitter in AMG, and histamine receptor activation is also reported to stimulate GABA release." | 1.31 | Modulation of audiogenically kindled seizures by gamma-aminobutyric acid-related mechanisms in the amygdala. ( Faingold, CL; Feng, HJ; Naritoku, DK; Randall, ME, 2001) |
| "In conclusion, the results confirm a genetic susceptibility in GAERS and/or resistance in inbred non-epileptic rats to focal and generalized seizures involving the cortex." | 1.30 | Susceptibility to focal and generalized seizures in Wistar rats with genetic absence-like epilepsy. ( Boehrer, A; Brailowsky, S; Marescaux, C; Montiel, T; Vergnes, M, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (5.77) | 18.2507 |
| 2000's | 48 (46.15) | 29.6817 |
| 2010's | 43 (41.35) | 24.3611 |
| 2020's | 7 (6.73) | 2.80 |
| Authors | Studies |
|---|---|
| Lybech, LKM | 1 |
| Calabró, M | 1 |
| Briuglia, S | 1 |
| Drago, A | 1 |
| Crisafulli, C | 1 |
| Suthakaran, N | 1 |
| Wiggins, J | 1 |
| Giles, A | 1 |
| Opperman, KJ | 1 |
| Grill, B | 1 |
| Dawson-Scully, K | 1 |
| Koko, M | 1 |
| Motelow, JE | 1 |
| Stanley, KE | 1 |
| Bobbili, DR | 1 |
| Dhindsa, RS | 1 |
| May, P | 1 |
| Jagadeesh, KA | 1 |
| Dey, KK | 1 |
| Montoro, DT | 1 |
| Mohan, R | 1 |
| Gazal, S | 1 |
| Engreitz, JM | 1 |
| Xavier, RJ | 1 |
| Price, AL | 1 |
| Regev, A | 1 |
| Kang, E | 1 |
| Song, J | 1 |
| Lin, Y | 1 |
| Park, J | 1 |
| Lee, JH | 1 |
| Hussani, Q | 1 |
| Gu, Y | 1 |
| Ge, S | 1 |
| Li, W | 1 |
| Hsu, KS | 1 |
| Berninger, B | 1 |
| Christian, KM | 1 |
| Song, H | 1 |
| Ming, GL | 1 |
| Li, Q | 1 |
| Parikh, H | 1 |
| Butterworth, MD | 1 |
| Lernmark, Å | 1 |
| Hagopian, W | 1 |
| Rewers, M | 1 |
| She, JX | 1 |
| Toppari, J | 1 |
| Ziegler, AG | 1 |
| Akolkar, B | 1 |
| Fiehn, O | 1 |
| Fan, S | 1 |
| Krischer, JP | 1 |
| Goetjen, A | 1 |
| Watson, M | 1 |
| Lieberman, R | 1 |
| Clinton, K | 1 |
| Kranzler, HR | 2 |
| Covault, J | 1 |
| Saha, S | 1 |
| Chatterjee, M | 1 |
| Sinha, S | 1 |
| Mukhopadhyay, K | 1 |
| Devor, A | 1 |
| Andreassen, OA | 1 |
| Wang, Y | 1 |
| Mäki-Marttunen, T | 1 |
| Smeland, OB | 1 |
| Fan, CC | 1 |
| Schork, AJ | 1 |
| Holland, D | 1 |
| Thompson, WK | 1 |
| Witoelar, A | 1 |
| Chen, CH | 1 |
| Desikan, RS | 1 |
| McEvoy, LK | 1 |
| Djurovic, S | 1 |
| Greengard, P | 1 |
| Svenningsson, P | 1 |
| Einevoll, GT | 1 |
| Dale, AM | 1 |
| Umeda, T | 1 |
| Kimura, T | 1 |
| Yoshida, K | 1 |
| Takao, K | 1 |
| Fujita, Y | 1 |
| Matsuyama, S | 1 |
| Sakai, A | 1 |
| Yamashita, M | 1 |
| Yamashita, Y | 1 |
| Ohnishi, K | 1 |
| Suzuki, M | 1 |
| Takuma, H | 1 |
| Miyakawa, T | 1 |
| Takashima, A | 1 |
| Morita, T | 1 |
| Mori, H | 1 |
| Tomiyama, T | 1 |
| Giacopuzzi, E | 1 |
| Gennarelli, M | 1 |
| Minelli, A | 1 |
| Gardella, R | 1 |
| Valsecchi, P | 1 |
| Traversa, M | 1 |
| Bonvicini, C | 1 |
| Vita, A | 1 |
| Sacchetti, E | 1 |
| Magri, C | 1 |
| Sahni, S | 1 |
| Tickoo, M | 1 |
| Gupta, R | 1 |
| Vaswani, M | 1 |
| Ambekar, A | 1 |
| Grover, T | 1 |
| Sharma, A | 1 |
| Mattison, KA | 1 |
| Butler, KM | 1 |
| Inglis, GAS | 1 |
| Dayan, O | 1 |
| Boussidan, H | 1 |
| Bhambhani, V | 1 |
| Philbrook, B | 1 |
| da Silva, C | 1 |
| Alexander, JJ | 1 |
| Kanner, BI | 1 |
| Escayg, A | 1 |
| Hampton, T | 1 |
| Hernandez, CC | 1 |
| XiangWei, W | 1 |
| Hu, N | 1 |
| Shen, D | 1 |
| Shen, W | 1 |
| Lagrange, AH | 1 |
| Zhang, Y | 2 |
| Dai, L | 1 |
| Ding, C | 1 |
| Sun, Z | 1 |
| Hu, J | 1 |
| Zhu, H | 1 |
| Jiang, Y | 1 |
| Macdonald, RL | 2 |
| Preuss, N | 1 |
| Salehi, B | 1 |
| van der Veen, JW | 1 |
| Shen, J | 1 |
| Drevets, WC | 1 |
| Hodgkinson, C | 1 |
| Goldman, D | 2 |
| Hasler, G | 1 |
| Schaefer, N | 1 |
| Langlhofer, G | 1 |
| Kluck, CJ | 1 |
| Villmann, C | 1 |
| Molina, V | 1 |
| Blanco, JA | 1 |
| Chukwu, J | 1 |
| Delanty, N | 1 |
| Webb, D | 1 |
| Cavalleri, GL | 1 |
| Forlani, G | 1 |
| Bertazzini, M | 1 |
| Giberti, S | 1 |
| Shushpanova, TV | 1 |
| Solonskii, AV | 1 |
| Novozheeva, TP | 1 |
| Udut, VV | 1 |
| Bailey, JN | 1 |
| Yaspan, BL | 1 |
| Pasquale, LR | 1 |
| Hauser, MA | 1 |
| Kang, JH | 1 |
| Loomis, SJ | 1 |
| Brilliant, M | 1 |
| Budenz, DL | 1 |
| Christen, WG | 1 |
| Fingert, J | 1 |
| Gaasterland, D | 1 |
| Gaasterland, T | 1 |
| Kraft, P | 1 |
| Lee, RK | 1 |
| Lichter, PR | 1 |
| Liu, Y | 1 |
| McCarty, CA | 1 |
| Moroi, SE | 1 |
| Richards, JE | 1 |
| Realini, T | 1 |
| Schuman, JS | 1 |
| Scott, WK | 1 |
| Singh, K | 1 |
| Sit, AJ | 1 |
| Vollrath, D | 1 |
| Wollstein, G | 1 |
| Zack, DJ | 1 |
| Zhang, K | 2 |
| Pericak-Vance, MA | 1 |
| Allingham, RR | 1 |
| Weinreb, RN | 1 |
| Haines, JL | 1 |
| Wiggs, JL | 1 |
| Matsushita, S | 1 |
| Higuchi, S | 1 |
| Hackett, CS | 1 |
| Quigley, DA | 1 |
| Wong, RA | 1 |
| Chen, J | 1 |
| Cheng, C | 1 |
| Song, YK | 1 |
| Wei, JS | 1 |
| Pawlikowska, L | 1 |
| Bao, Y | 1 |
| Goldenberg, DD | 1 |
| Nguyen, K | 1 |
| Gustafson, WC | 1 |
| Rallapalli, SK | 1 |
| Cho, YJ | 1 |
| Cook, JM | 1 |
| Kozlov, S | 1 |
| Mao, JH | 1 |
| Van Dyke, T | 1 |
| Kwok, PY | 1 |
| Khan, J | 1 |
| Balmain, A | 1 |
| Fan, Q | 1 |
| Weiss, WA | 1 |
| Bonnet-Brilhault, F | 1 |
| Alirol, S | 1 |
| Blanc, R | 1 |
| Bazaud, S | 1 |
| Marouillat, S | 1 |
| Thépault, RA | 1 |
| Andres, CR | 1 |
| Lemonnier, É | 1 |
| Barthélémy, C | 1 |
| Raynaud, M | 1 |
| Toutain, A | 1 |
| Gomot, M | 1 |
| Laumonnier, F | 1 |
| de la Fuente-Sandoval, C | 1 |
| Reyes-Madrigal, F | 1 |
| Mao, X | 1 |
| León-Ortiz, P | 1 |
| Rodríguez-Mayoral, O | 1 |
| Solís-Vivanco, R | 1 |
| Favila, R | 1 |
| Graff-Guerrero, A | 1 |
| Shungu, DC | 1 |
| Wu, LS | 1 |
| Lee, CS | 1 |
| Weng, TY | 1 |
| Wang, KH | 1 |
| Cheng, AT | 1 |
| Zhao, Y | 1 |
| Wang, Q | 1 |
| Jiang, H | 1 |
| Du, J | 2 |
| Yu, S | 1 |
| Zhao, M | 1 |
| Thakkar, KN | 1 |
| Rösler, L | 1 |
| Wijnen, JP | 1 |
| Boer, VO | 1 |
| Klomp, DW | 1 |
| Cahn, W | 1 |
| Kahn, RS | 1 |
| Neggers, SF | 1 |
| Li, Z | 1 |
| Tang, T | 1 |
| Wu, W | 1 |
| Zhou, X | 1 |
| Qin, G | 1 |
| Wang, L | 1 |
| Jiang, W | 1 |
| Lin, Q | 1 |
| Zhao, C | 1 |
| Chen, YW | 1 |
| Surgent, O | 1 |
| Rana, BS | 1 |
| Lee, F | 1 |
| Aoki, C | 1 |
| Crabtree, GW | 1 |
| Park, AJ | 1 |
| Gordon, JA | 1 |
| Gogos, JA | 1 |
| Balan, S | 1 |
| Yamada, K | 3 |
| Iwayama, Y | 1 |
| Hashimoto, T | 2 |
| Toyota, T | 1 |
| Shimamoto, C | 1 |
| Maekawa, M | 1 |
| Takagai, S | 1 |
| Wakuda, T | 1 |
| Kameno, Y | 1 |
| Kurita, D | 1 |
| Kikuchi, M | 1 |
| Kanahara, N | 1 |
| Yoshikawa, T | 2 |
| Chiu, C | 1 |
| Reid, CA | 1 |
| Tan, HO | 1 |
| Davies, PJ | 1 |
| Single, FN | 1 |
| Koukoulas, I | 1 |
| Berkovic, SF | 1 |
| Tan, SS | 1 |
| Sprengel, R | 1 |
| Jones, MV | 1 |
| Petrou, S | 1 |
| Choi, DS | 1 |
| Wei, W | 1 |
| Deitchman, JK | 1 |
| Kharazia, VN | 1 |
| Lesscher, HM | 1 |
| McMahon, T | 1 |
| Wang, D | 1 |
| Qi, ZH | 1 |
| Sieghart, W | 1 |
| Zhang, C | 1 |
| Shokat, KM | 1 |
| Mody, I | 1 |
| Messing, RO | 1 |
| Costa, E | 3 |
| Chen, Y | 1 |
| Dong, E | 2 |
| Grayson, DR | 3 |
| Kundakovic, M | 2 |
| Maloku, E | 1 |
| Ruzicka, W | 1 |
| Satta, R | 2 |
| Veldic, M | 1 |
| Zhubi, A | 1 |
| Guidotti, A | 3 |
| Suzuki, T | 1 |
| Miyamoto, H | 1 |
| Nakahari, T | 1 |
| Inoue, I | 1 |
| Suemoto, T | 1 |
| Jiang, B | 1 |
| Hirota, Y | 1 |
| Itohara, S | 1 |
| Saido, TC | 1 |
| Tsumoto, T | 1 |
| Sawamoto, K | 1 |
| Hensch, TK | 1 |
| Delgado-Escueta, AV | 1 |
| Yamakawa, K | 1 |
| Conner, BT | 1 |
| Hellemann, GS | 1 |
| Ritchie, TL | 1 |
| Noble, EP | 1 |
| Kim, S | 1 |
| Webster, MJ | 1 |
| Wolfe, KC | 1 |
| Poma, R | 1 |
| Luscher, B | 1 |
| Shen, Q | 1 |
| Sahir, N | 1 |
| Saba, LM | 1 |
| Bennett, B | 1 |
| Hoffman, PL | 1 |
| Barcomb, K | 1 |
| Ishii, T | 1 |
| Kechris, K | 1 |
| Tabakoff, B | 1 |
| Akakin, D | 2 |
| Sirvanci, S | 2 |
| Gurbanova, A | 1 |
| Aker, R | 1 |
| Onat, F | 2 |
| San, T | 2 |
| Thier, S | 1 |
| Kuhlenbäumer, G | 1 |
| Lorenz, D | 1 |
| Nothnagel, M | 1 |
| Nebel, A | 1 |
| Christensen, K | 1 |
| Schreiber, S | 1 |
| Deuschl, G | 1 |
| Klebe, S | 1 |
| Kim, DU | 1 |
| Kim, MK | 1 |
| Cho, YW | 1 |
| Kim, YS | 1 |
| Kim, WJ | 1 |
| Lee, MG | 1 |
| Kim, SE | 1 |
| Nam, TS | 1 |
| Cho, KH | 1 |
| Kim, YO | 1 |
| Lee, MC | 1 |
| Arinami, T | 1 |
| Inada, T | 1 |
| Miguéns, M | 1 |
| Botreau, F | 1 |
| Olías, O | 1 |
| Del Olmo, N | 1 |
| Coria, SM | 1 |
| Higuera-Matas, A | 1 |
| Ambrosio, E | 1 |
| Buscemi, L | 1 |
| Turchi, C | 1 |
| Canillioglu, Y | 1 |
| Midillioglu, S | 1 |
| Yildiz, SD | 1 |
| Yin, DM | 1 |
| Chen, YJ | 1 |
| Sathyamurthy, A | 1 |
| Xiong, WC | 1 |
| Mei, L | 1 |
| Uhart, M | 1 |
| Weerts, EM | 1 |
| McCaul, ME | 1 |
| Guo, X | 1 |
| Yan, X | 1 |
| Li, N | 1 |
| Wand, GS | 1 |
| Burri, A | 1 |
| Hysi, P | 1 |
| Clop, A | 1 |
| Rahman, Q | 1 |
| Spector, TD | 1 |
| Brockington, A | 1 |
| Ning, K | 1 |
| Heath, PR | 1 |
| Wood, E | 1 |
| Kirby, J | 1 |
| Fusi, N | 1 |
| Lawrence, N | 1 |
| Wharton, SB | 1 |
| Ince, PG | 1 |
| Shaw, PJ | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Autism and Glutamatergic Synapse : Research of Genetic Mutations and Identification of Clinical and Neurophysiological Markers.[NCT01770548] | 497 participants (Actual) | Interventional | 2009-01-31 | Completed | |||
| Evaluation of Schemes of Administration of Intravenous Ketamine in Treatment-resistant Depression: Clinical-neuroimaging Correlation[NCT03742557] | Phase 3 | 30 participants (Anticipated) | Interventional | 2018-10-01 | Recruiting | ||
| A Phase I Randomized, Double-blinded, Placebo-controlled Dose Escalation Study to Evaluate the Safety, Tolerability, and Pharmacokinetic of HS-10353 in Chinese Adult Subjects[NCT05195203] | Phase 1 | 96 participants (Actual) | Interventional | 2021-01-27 | Completed | ||
| Role of the Gut Microbiome as Determinant of Depression in Multiple Sclerosis Subjects[NCT05808101] | 120 participants (Anticipated) | Observational | 2022-01-27 | Recruiting | |||
| Imaging Framework for Testing GABAergic/Glutamatergic Drugs in Bipolar Alcoholics[NCT03220776] | Phase 2 | 54 participants (Actual) | Interventional | 2017-08-07 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Concentrations of GABA+, referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy (i.e., MEGA-PRESS). (NCT03220776)
Timeframe: Day 5 of each experimental condition
| Intervention | mmol/kg (Mean) |
|---|---|
| N-Acetylcysteine | 3.90 |
| Gabapentin | 3.93 |
| Placebo Oral Tablet | 3.73 |
Concentrations of Glx (i.e., glutamate + glutamine), referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy. (NCT03220776)
Timeframe: Day 5 of each experimental condition
| Intervention | mmol/kg (Mean) |
|---|---|
| N-Acetylcysteine | 21.59 |
| Gabapentin | 21.69 |
| Placebo Oral Tablet | 22.25 |
23 reviews available for gamma-aminobutyric acid and Genetic Predisposition
| Article | Year |
|---|---|
Genetic evidence for role of integration of fast and slow neurotransmission in schizophrenia.
Topics: Brain; Dopamine; Dopamine and cAMP-Regulated Phosphoprotein 32; gamma-Aminobutyric Acid; Genetic Pre | 2017 |
Glycine receptor mouse mutants: model systems for human hyperekplexia.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Genetic Predisposition to Disease; Glycine | 2013 |
A proposal for reframing schizophrenia research.
Topics: Antipsychotic Agents; Brain; Displacement, Psychological; DNA Copy Number Variations; DNA Mutational | 2013 |
Weight change, genetics and antiepileptic drugs.
Topics: Animals; Anticonvulsants; Epilepsy; gamma-Aminobutyric Acid; Genetic Predisposition to Disease; Huma | 2014 |
Genetic differences in response to alcohol.
Topics: Alcohol Dehydrogenase; Alcohol Drinking; Alcoholism; Aldehyde Dehydrogenase; Animals; Ethanol; gamma | 2014 |
GABAergic promoter hypermethylation as a model to study the neurochemistry of schizophrenia vulnerability.
Topics: Animals; Antipsychotic Agents; Brain; Cell Adhesion Molecules, Neuronal; DNA Methylation; Epigenesis | 2009 |
[Genome-wide association analyses for neuroleptic-induced tardive dyskinesia].
Topics: Acetylcholine; Animals; Antipsychotic Agents; gamma-Aminobutyric Acid; Genetic Predisposition to Dis | 2011 |
An overview of the genetic susceptibility to alcoholism.
Topics: Alcohol Dehydrogenase; Alcoholism; gamma-Aminobutyric Acid; Genetic Linkage; Genetic Predisposition | 2011 |
Synaptic dysfunction in schizophrenia.
Topics: Acetylcholine; Animals; Brain; Dopamine; gamma-Aminobutyric Acid; Gene Expression Regulation, Develo | 2012 |
[Generalized anxiety disorder].
Topics: Adrenergic Uptake Inhibitors; Anxiety Disorders; Cognitive Behavioral Therapy; Diagnostic and Statis | 2003 |
Neurobiological correlates of the disposition and maintenance of alcoholism.
Topics: Acute Disease; Alcoholism; Brain; Chronic Disease; Dopamine; Drug Tolerance; Ethanol; gamma-Aminobut | 2003 |
Postmortem investigations of the pathophysiology of schizophrenia: the role of susceptibility genes.
Topics: Catechol O-Methyltransferase; Corpus Striatum; Dopamine; gamma-Aminobutyric Acid; Genetic Predisposi | 2004 |
Autism and 15q11-q13 disorders: behavioral, genetic, and pathophysiological issues.
Topics: Animals; Autistic Disorder; Brain; Chromosome Aberrations; Chromosomes, Human, Pair 15; gamma-Aminob | 2004 |
Molecular and cellular mechanisms of altered GAD1/GAD67 expression in schizophrenia and related disorders.
Topics: Animals; Brain; Down-Regulation; gamma-Aminobutyric Acid; Gene Expression Regulation, Enzymologic; G | 2006 |
Major affective disorders and schizophrenia: a common molecular signature?
Topics: Dopamine; gamma-Aminobutyric Acid; Genetic Predisposition to Disease; Glutamic Acid; Humans; Mood Di | 2006 |
Gamma-aminobutyric acid type A receptors and alcoholism: intoxication, dependence, vulnerability, and treatment.
Topics: Alcoholism; Benzodiazepines; Brain; Cerebral Cortex; gamma-Aminobutyric Acid; Gene Expression; Genet | 2006 |
GABAergic malfunction in the limbic system resulting from an aboriginal genetic defect in voltage-gated Na+-channel SCN5A is proposed to give rise to susceptibility to schizophrenia.
Topics: gamma-Aminobutyric Acid; Gene Deletion; Genetic Predisposition to Disease; Humans; Limbic System; Mo | 2006 |
[Autism, chromosome 15 and the GAbaergic dysfunction hypothesis].
Topics: Angelman Syndrome; Animals; Autistic Disorder; Chromosome Deletion; Chromosome Mapping; Chromosomes, | 2007 |
Narcolepsy: a key role for hypocretins (orexins)
Topics: Animals; Appetite; Arousal; Calcium Signaling; Carrier Proteins; Cataplexy; Chromosomes, Human, Pair | 1999 |
Tourette's syndrome: when habit-forming systems form habits of their own?
Topics: Animals; Autoimmunity; Basal Ganglia; Cerebral Cortex; Disease Models, Animal; gamma-Aminobutyric Ac | 2000 |
Pathophysiology of epilepsy.
Topics: Adult; Animals; Anticonvulsants; Autoimmune Diseases; Calcium; Catecholamines; Cell Movement; Child; | 2000 |
Toward an integrative understanding of social phobia.
Topics: Animals; Brain; Disease Models, Animal; gamma-Aminobutyric Acid; Genetic Predisposition to Disease; | 2001 |
Dendritic spine hypoplasticity and downregulation of reelin and GABAergic tone in schizophrenia vulnerability.
Topics: Adolescent; Adult; Age of Onset; Animals; Antigens, CD; Bipolar Disorder; Brain; Cell Adhesion Molec | 2001 |
1 trial available for gamma-aminobutyric acid and Genetic Predisposition
| Article | Year |
|---|---|
The collaborative study on the genetics of alcoholism: an update.
Topics: Alcoholism; Brain; Diagnostic and Statistical Manual of Mental Disorders; gamma-Aminobutyric Acid; G | 2002 |
80 other studies available for gamma-aminobutyric acid and Genetic Predisposition
| Article | Year |
|---|---|
Suicide Related Phenotypes in a Bipolar Sample: Genetic Underpinnings.
Topics: Adult; Aged; Aminopeptidases; Bipolar Disorder; gamma-Aminobutyric Acid; Genetic Predisposition to D | 2021 |
O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 modulate seizure susceptibility in C. elegans.
Topics: Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Disease Susceptibility; GABAergic | 2021 |
Association of ultra-rare coding variants with genetic generalized epilepsy: A case-control whole exome sequencing study.
Topics: Case-Control Studies; Epilepsy, Generalized; Exome Sequencing; gamma-Aminobutyric Acid; Genetic Pred | 2022 |
Identifying disease-critical cell types and cellular processes by integrating single-cell RNA-sequencing and human genetics.
Topics: Depressive Disorder, Major; gamma-Aminobutyric Acid; Genetic Predisposition to Disease; Genome-Wide | 2022 |
Interplay between a Mental Disorder Risk Gene and Developmental Polarity Switch of GABA Action Leads to Excitation-Inhibition Imbalance.
Topics: Animals; Cell Polarity; Female; GABAergic Neurons; gamma-Aminobutyric Acid; Gene Knockdown Technique | 2019 |
Longitudinal Metabolome-Wide Signals Prior to the Appearance of a First Islet Autoantibody in Children Participating in the TEDDY Study.
Topics: Alanine; Amino Acids, Branched-Chain; Autoantibodies; Child, Preschool; Dehydroascorbic Acid; Diabet | 2020 |
Induced pluripotent stem cell reprogramming-associated methylation at the GABRA2 promoter and chr4p12 GABA
Topics: Adult; Alcoholism; Cellular Reprogramming; Chromosomes, Human, Pair 4; DNA Methylation; Female; Fibr | 2020 |
A pioneering study indicate role of GABRQ rs3810651 in ASD severity of Indo-Caucasoid female probands.
Topics: Autism Spectrum Disorder; Case-Control Studies; Child; Child, Preschool; Chromosomes, Human, X; Fema | 2021 |
Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer's disease: analysis of Osaka mutation-knockin mice.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Diazepam; Disease Models, Animal; | 2017 |
Exome sequencing in schizophrenic patients with high levels of homozygosity identifies novel and extremely rare mutations in the GABA/glutamatergic pathways.
Topics: Adolescent; Adult; Aged; DNA Mutational Analysis; Exome; Female; gamma-Aminobutyric Acid; Genetic Pr | 2017 |
Association of serotonin and GABA pathway gene polymorphisms with alcohol dependence: A preliminary study.
Topics: Adolescent; Adult; Alcoholism; gamma-Aminobutyric Acid; Genetic Predisposition to Disease; Humans; I | 2019 |
SLC6A1 variants identified in epilepsy patients reduce γ-aminobutyric acid transport.
Topics: Cohort Studies; DNA Mutational Analysis; Epilepsy; Female; GABA Plasma Membrane Transport Proteins; | 2018 |
Research Reveals Mechanism That May Drive Alcohol Use Disorder.
Topics: Alcoholism; Amygdala; Animals; Behavior, Addictive; Disease Models, Animal; Down-Regulation; Ethanol | 2018 |
Altered inhibitory synapses in de novo GABRA5 and GABRA1 mutations associated with early onset epileptic encephalopathies.
Topics: Child; Child, Preschool; Epilepsy; Female; gamma-Aminobutyric Acid; Genetic Predisposition to Diseas | 2019 |
Associations between prefrontal γ-aminobutyric acid concentration and the tryptophan hydroxylase isoform 2 gene, a panic disorder risk allele in women.
Topics: Adult; Alleles; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Genetic Association Stu | 2013 |
Differential accumulation of γ-aminobutyric acid in elicited cells of two rice cultivars showing contrasting sensitivity to the blast pathogen.
Topics: Cells, Cultured; gamma-Aminobutyric Acid; Genetic Predisposition to Disease; Genotype; Homeostasis; | 2014 |
Effect of meta-chlorobenzhydryl urea (m-ClBHU) on benzodiazepine receptor system in rat brain during experimental alcoholism.
Topics: Alcoholism; Animals; Anticonvulsants; Benzodiazepinones; Brain; Flunitrazepam; gamma-Aminobutyric Ac | 2014 |
Hypothesis-independent pathway analysis implicates GABA and acetyl-CoA metabolism in primary open-angle glaucoma and normal-pressure glaucoma.
Topics: Acetyl Coenzyme A; Case-Control Studies; Cluster Analysis; Female; gamma-Aminobutyric Acid; Genetic | 2014 |
Expression quantitative trait loci and receptor pharmacology implicate Arg1 and the GABA-A receptor as therapeutic targets in neuroblastoma.
Topics: Animals; Apoptosis; Arginase; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Chromosomes, Mammali | 2014 |
GABA/Glutamate synaptic pathways targeted by integrative genomic and electrophysiological explorations distinguish autism from intellectual disability.
Topics: Acoustic Stimulation; Autistic Disorder; Cell Adhesion Molecules, Neuronal; Child, Preschool; Electr | 2016 |
Cortico-Striatal GABAergic and Glutamatergic Dysregulations in Subjects at Ultra-High Risk for Psychosis Investigated with Proton Magnetic Resonance Spectroscopy.
Topics: Corpus Striatum; Female; gamma-Aminobutyric Acid; Genetic Predisposition to Disease; Glutamic Acid; | 2015 |
Association Study of Gene Polymorphisms in GABA, Serotonin, Dopamine, and Alcohol Metabolism Pathways with Alcohol Dependence in Taiwanese Han Men.
Topics: Adult; Alcohol Dehydrogenase; Alcoholism; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondr | 2016 |
Association study of GABA system genes polymorphisms with amphetamine-induced psychotic disorder in a Han Chinese population.
Topics: Adult; Amphetamine; Asian People; Case-Control Studies; Female; gamma-Aminobutyric Acid; Gene Freque | 2016 |
7T Proton Magnetic Resonance Spectroscopy of Gamma-Aminobutyric Acid, Glutamate, and Glutamine Reveals Altered Concentrations in Patients With Schizophrenia and Healthy Siblings.
Topics: Adult; Brain; Female; gamma-Aminobutyric Acid; Genetic Predisposition to Disease; Glutamic Acid; Glu | 2017 |
Association between Single Nucleotide Polymorphisms in Gamma-Aminobutyric Acid B Receptor, Insulin Receptor Substrate-1, and Hypocretin Neuropeptide Precursor Genes and Susceptibility to Obstructive Sleep Apnea Hypopnea Syndrome in a Chinese Han Populatio
Topics: Adult; Aged; Body Mass Index; Case-Control Studies; China; Female; gamma-Aminobutyric Acid; Gene Fre | 2016 |
DNA methylation regulates gabrb2 mRNA expression: developmental variations and disruptions in l-methionine-induced zebrafish with schizophrenia-like symptoms.
Topics: Animals; Disease Models, Animal; DNA Methylation; gamma-Aminobutyric Acid; Gene Expression Regulatio | 2016 |
Variant BDNF-Val66Met Polymorphism is Associated with Layer-Specific Alterations in GABAergic Innervation of Pyramidal Neurons, Elevated Anxiety and Reduced Vulnerability of Adolescent Male Mice to Activity-Based Anorexia.
Topics: Animals; Anorexia; Anxiety; Brain-Derived Neurotrophic Factor; CA1 Region, Hippocampal; Dendrites; D | 2017 |
Cytosolic Accumulation of L-Proline Disrupts GABA-Ergic Transmission through GAD Blockade.
Topics: Animals; Central Nervous System; Cytosol; Disease Models, Animal; Gamma Rhythm; gamma-Aminobutyric A | 2016 |
Comprehensive association analysis of 27 genes from the GABAergic system in Japanese individuals affected with schizophrenia.
Topics: Adult; Aged; Asian People; Carrier Proteins; Female; gamma-Aminobutyric Acid; Gene Frequency; Geneti | 2017 |
Developmental impact of a familial GABAA receptor epilepsy mutation.
Topics: Animals; Brain; Brain Chemistry; Convulsants; Disease Models, Animal; Epilepsy; gamma-Aminobutyric A | 2008 |
Protein kinase Cdelta regulates ethanol intoxication and enhancement of GABA-stimulated tonic current.
Topics: Alcohol-Induced Disorders, Nervous System; Animals; Benzodiazepines; Brain; Cells, Cultured; Central | 2008 |
Characterization of the action of antipsychotic subtypes on valproate-induced chromatin remodeling.
Topics: Animals; Antipsychotic Agents; Cell Adhesion Molecules, Neuronal; Chromatin Assembly and Disassembly | 2009 |
Efhc1 deficiency causes spontaneous myoclonus and increased seizure susceptibility.
Topics: Animals; Calcium-Binding Proteins; Cerebral Ventricles; Cilia; Convulsants; Dentate Gyrus; gamma-Ami | 2009 |
Genetic, personality, and environmental predictors of drug use in adolescents.
Topics: Adolescent; Adolescent Behavior; Depression; Dopamine; Family; Female; gamma-Aminobutyric Acid; Gene | 2010 |
Integrative genome-wide association analysis of cytoarchitectural abnormalities in the prefrontal cortex of psychiatric disorders.
Topics: Adult; Amino Acid Transport System A; Calbindins; Databases, Genetic; Female; gamma-Aminobutyric Aci | 2011 |
Syringomyelia in the Cavalier King Charles spaniel (CKCS) dog.
Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents; Arnold-Chiari Malformation; Breeding; Cyclohe | 2010 |
The GABAergic deficit hypothesis of major depressive disorder.
Topics: Animals; Antidepressive Agents; Brain; Depressive Disorder, Major; Disease Models, Animal; gamma-Ami | 2011 |
The GABAergic deficit hypothesis of major depressive disorder.
Topics: Animals; Antidepressive Agents; Brain; Depressive Disorder, Major; Disease Models, Animal; gamma-Ami | 2011 |
The GABAergic deficit hypothesis of major depressive disorder.
Topics: Animals; Antidepressive Agents; Brain; Depressive Disorder, Major; Disease Models, Animal; gamma-Ami | 2011 |
The GABAergic deficit hypothesis of major depressive disorder.
Topics: Animals; Antidepressive Agents; Brain; Depressive Disorder, Major; Disease Models, Animal; gamma-Ami | 2011 |
A systems genetic analysis of alcohol drinking by mice, rats and men: influence of brain GABAergic transmission.
Topics: Alcohol Drinking; Animals; Brain; Central Nervous System Depressants; Ethanol; gamma-Aminobutyric Ac | 2011 |
Ultrastructural GABA immunocytochemistry in the mossy fiber terminals of Wistar and genetic absence epileptic rats receiving amygdaloid kindling stimulations.
Topics: Amygdala; Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy, Absence; Epilepsy, Temporal Lobe | 2011 |
GABA(A) receptor- and GABA transporter polymorphisms and risk for essential tremor.
Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; Essential Tremor; Female; GABA Plasma Membrane | 2011 |
Association of a synonymous GAT3 polymorphism with antiepileptic drug pharmacoresistance.
Topics: Adolescent; Adult; Anticonvulsants; Brain; Case-Control Studies; Child; Child, Preschool; Drug Resis | 2011 |
Genetic differences in the modulation of accumbal glutamate and γ-amino butyric acid levels after cocaine-induced reinstatement.
Topics: Analysis of Variance; Animals; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine | 2013 |
Glutamic acid decarboxylase immunoreactivity in the mossy fiber terminals of the hippocampus of genetic absence epileptic rats.
Topics: Animals; CA3 Region, Hippocampal; Dentate Gyrus; Disease Models, Animal; Epilepsy, Absence; gamma-Am | 2011 |
GABRA2 markers moderate the subjective effects of alcohol.
Topics: Adult; Alcoholic Intoxication; Alcoholism; Alleles; Chromosomes, Human, Pair 4; Cohort Studies; Dose | 2013 |
A genome-wide association study of female sexual dysfunction.
Topics: Adult; Aged; Aged, 80 and over; Alleles; Chromosomes, Human, Pair 6; Female; gamma-Aminobutyric Acid | 2012 |
Unravelling the enigma of selective vulnerability in neurodegeneration: motor neurons resistant to degeneration in ALS show distinct gene expression characteristics and decreased susceptibility to excitotoxicity.
Topics: Aged; Amyotrophic Lateral Sclerosis; Female; gamma-Aminobutyric Acid; Gene Expression Regulation; Ge | 2013 |
Changes in extracellular levels of amygdala amino acids in genetically fast and slow kindling rat strains.
Topics: Amino Acids; Amygdala; Animals; Differential Threshold; Electrophysiology; Extracellular Space; gamm | 2002 |
Genetic disruption of cortical interneuron development causes region- and GABA cell type-specific deficits, epilepsy, and behavioral dysfunction.
Topics: Animals; Anxiety; Behavior, Animal; Calcium-Binding Proteins; Cell Count; Darkness; Electroencephalo | 2003 |
Evidence of association between gamma-aminobutyric acid type A receptor genes located on 5q34 and female patients with mood disorders.
Topics: Adult; Brain; Brain Chemistry; Chromosomes, Human, Pair 5; DNA Mutational Analysis; Female; gamma-Am | 2003 |
Selective changes in gamma-aminobutyric acid type A receptor subunits in the hippocampus in spontaneously seizing rats with chronic temporal lobe epilepsy.
Topics: Animals; Chronic Disease; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; gamma-Aminobuty | 2003 |
Potential pleiotropic effects of Mpdz on vulnerability to seizures.
Topics: Amino Acid Motifs; Animals; Carrier Proteins; Chromosome Mapping; Convulsants; Ethanol; Female; gamm | 2004 |
Neuronal vulnerability following inhibition of mitochondrial complex II: a possible ionic mechanism for Huntington's disease.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Cell Respiration; Dose-Response Relationship, Drug; | 2004 |
Parvalbumin deficiency affects network properties resulting in increased susceptibility to epileptic seizures.
Topics: Action Potentials; Animals; Brain; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Geneti | 2004 |
Association between nonsyndromic cleft lip with or without cleft palate and the glutamic acid decarboxylase 67 gene in the Japanese population.
Topics: Asian People; Case-Control Studies; Chromatography, High Pressure Liquid; Cleft Lip; Cleft Palate; D | 2004 |
Electrophysiological properties of cultured hippocampal neurons from Wistar Audiogenic Rats.
Topics: Action Potentials; Animals; Animals, Newborn; Cell Membrane; Cells, Cultured; Disease Models, Animal | 2005 |
Alternative splicing and promoter use in the human GABRA2 gene.
Topics: Alcoholism; Alternative Splicing; Base Sequence; Brain; Brain Chemistry; Exons; gamma-Aminobutyric A | 2005 |
Five mutations in the GABA A alpha6 gene 5' flanking region are associated with a reduced basal and ethanol-induced alpha6 upregulation in mutated Sardinian alcohol non-preferring rats.
Topics: 5' Flanking Region; Alcohol-Induced Disorders, Nervous System; Alcoholism; Animals; Base Pairing; Ba | 2005 |
Stiff child syndrome with mutation of DYT1 gene.
Topics: Asian People; Autoantibodies; Child; Disease Progression; DNA Mutational Analysis; Dystonia; GABA Ag | 2005 |
Clinical correlates of quantitative EEG alterations in alcoholic patients.
Topics: Adult; Age Factors; Aged; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders, Nervous System; Al | 2006 |
Genetic analysis of the GABRA1 gene in patients with essential tremor.
Topics: Adult; Aged; Brain; Brain Chemistry; Chromosomes, Human, Pair 5; DNA Mutational Analysis; Essential | 2006 |
GABA and opioid binding distribution in the brain of the seizure-resistant Proechimys guyannensis: an autoradiography study.
Topics: Animals; Autoradiography; Benzodiazepines; Binding, Competitive; Brain; Epilepsy; GABA Agonists; gam | 2006 |
GABA(A) receptor mediated transmission in the thalamic reticular nucleus of rats with genetic absence epilepsy shows regional differences: functional implications.
Topics: Action Potentials; Afferent Pathways; Animals; Basal Ganglia; Bicuculline; Cerebral Cortex; Disease | 2006 |
Mutations in the K+/Cl- cotransporter gene kazachoc (kcc) increase seizure susceptibility in Drosophila.
Topics: Animals; Chromosome Mapping; Drosophila melanogaster; gamma-Aminobutyric Acid; Genetic Predispositio | 2006 |
Glutamic acid decarboxylase antibodies in idiopathic generalized epilepsy and type 1 diabetes.
Topics: Adolescent; Autoantibodies; Biomarkers; Brain; Diabetes Mellitus, Type 1; Epilepsy; gamma-Aminobutyr | 2008 |
Systematic study of association of four GABAergic genes: glutamic acid decarboxylase 1 gene, glutamic acid decarboxylase 2 gene, GABA(B) receptor 1 gene and GABA(A) receptor subunit beta2 gene, with schizophrenia using a universal DNA microarray.
Topics: Adult; Asian People; Case-Control Studies; China; Electrophoretic Mobility Shift Assay; Female; gamm | 2007 |
Aberrant cerebellar granule cell-specific GABAA receptor expression in the epileptic and ataxic mouse mutant, Tottering.
Topics: Animals; Binding, Competitive; Calcium Channels, N-Type; Cerebellar Ataxia; Cerebellar Cortex; Disea | 2007 |
Astrocytes may play a role in the etiology of absence epilepsy: a comparison between immature GAERS not yet expressing seizures and adults.
Topics: Acetic Acid; Aging; Animals; Astrocytes; Brain; Cell Communication; Cell Differentiation; Disease Mo | 2007 |
Mechanism of age-dependent susceptibility and novel treatment strategy in glutaric acidemia type I.
Topics: Aging; Amino Acid Metabolism, Inborn Errors; Animals; Brain Diseases, Metabolic, Inborn; Child; Diet | 2007 |
Human gamma-aminobutyric acid A receptor alpha2 gene moderates the acute effects of alcohol and brain mRNA expression.
Topics: Adult; Alcohol-Induced Disorders, Nervous System; Alcoholism; Brain Chemistry; Central Nervous Syste | 2008 |
Early defects of GABAergic synapses in the brain stem of a MeCP2 mouse model of Rett syndrome.
Topics: Animals; Brain Stem; Disease Models, Animal; Efferent Pathways; Excitatory Postsynaptic Potentials; | 2008 |
Regional differences in hippocampal excitability manifested by paired-pulse stimulation of genetically epileptic El mice.
Topics: Action Potentials; Animals; Electric Stimulation; Epilepsy; Excitatory Postsynaptic Potentials; gamm | 1998 |
Seizure sensitivity and GABAergic modulation of ethanol sensitivity in selectively bred FAST and SLOW mouse lines.
Topics: Animals; Baclofen; Ethanol; GABA Modulators; gamma-Aminobutyric Acid; Genetic Predisposition to Dise | 1998 |
GABAA alpha-1 subunit gene not associated with depressive symptomatology in mood disorders.
Topics: Adult; Anxiety; Bipolar Disorder; Delusions; Depression; DNA; Female; gamma-Aminobutyric Acid; Genet | 1998 |
Susceptibility to focal and generalized seizures in Wistar rats with genetic absence-like epilepsy.
Topics: Animals; Convulsants; Electroencephalography; Epilepsies, Partial; Epilepsy, Absence; Epilepsy, Gene | 1999 |
Evidence for the segregation of a major gene for human plasma GABA levels.
Topics: Adolescent; Adult; Chromosome Segregation; Family Health; Female; gamma-Aminobutyric Acid; Genes, Re | 1999 |
Alterations in neuronal gamma-aminobutyric acid(A) receptor responsiveness in genetic models of seizure susceptibility with different expression patterns.
Topics: Age Factors; Animals; Dose-Response Relationship, Drug; Epilepsy; gamma-Aminobutyric Acid; Genetic P | 2000 |
Phenotypic expression of the systemic toxicity of cocaine in genetically epilepsy-prone rats.
Topics: Animals; Arrhythmias, Cardiac; Cocaine; Electroencephalography; Epilepsy; gamma-Aminobutyric Acid; G | 2000 |
Overexpression of gamma-aminobutyric acid transporter subtype I leads to susceptibility to kainic acid-induced seizure in transgenic mice.
Topics: Action Potentials; Amino Acid Transport System X-AG; Animals; ATP-Binding Cassette Transporters; Bra | 2001 |
Modulation of audiogenically kindled seizures by gamma-aminobutyric acid-related mechanisms in the amygdala.
Topics: Acoustic Stimulation; Amygdala; Animals; Epilepsy; GABA Agonists; gamma-Aminobutyric Acid; Genetic P | 2001 |
Two different mechanisms of disinhibition produced by GABAA receptor mutations linked to epilepsy in humans.
Topics: Cells, Cultured; Diazepam; Dose-Response Relationship, Drug; Electric Conductivity; Epilepsy; GABA M | 2002 |