gamma-aminobutyric acid has been researched along with Frontotemporal Lobar Degeneration in 3 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
Frontotemporal Lobar Degeneration: Heterogeneous group of neurodegenerative disorders characterized by frontal and temporal lobe atrophy associated with neuronal loss, gliosis, and dementia. Patients exhibit progressive changes in social, behavioral, and/or language function. Multiple subtypes or forms are recognized based on presence or absence of TAU PROTEIN inclusions. FTLD includes three clinical syndromes: FRONTOTEMPORAL DEMENTIA, semantic dementia, and PRIMARY PROGRESSIVE NONFLUENT APHASIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have generated a FTLD-U mouse model (CaMKII-TDP-43 Tg) in which TDP-43 is transgenically overexpressed in the forebrain resulting in phenotypic characteristics mimicking those of FTLD-U." | 1.36 | Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U. ( Chien, WL; Cho, KH; Fang, YH; Fu, WM; Lin, CP; Shen, CK; Tsai, KJ; Wang, WT; Wu, TW; Yang, CH, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 2 (66.67) | 2.80 |
| Authors | Studies |
|---|---|
| Perry, A | 1 |
| Hughes, LE | 1 |
| Adams, N | 1 |
| Naessens, M | 1 |
| Murley, AG | 2 |
| Rouse, MA | 2 |
| Street, D | 1 |
| Jones, PS | 2 |
| Cope, TE | 1 |
| Kocagoncu, E | 1 |
| Rowe, JB | 2 |
| Ye, R | 1 |
| Hezemans, FH | 1 |
| O'Callaghan, C | 1 |
| Frangou, P | 1 |
| Kourtzi, Z | 1 |
| Rua, C | 1 |
| Carpenter, TA | 1 |
| Rodgers, CT | 1 |
| Tsai, KJ | 1 |
| Yang, CH | 1 |
| Fang, YH | 1 |
| Cho, KH | 1 |
| Chien, WL | 1 |
| Wang, WT | 1 |
| Wu, TW | 1 |
| Lin, CP | 1 |
| Fu, WM | 1 |
| Shen, CK | 1 |
3 other studies available for gamma-aminobutyric acid and Frontotemporal Lobar Degeneration
| Article | Year |
|---|---|
The neurophysiological effect of NMDA-R antagonism of frontotemporal lobar degeneration is conditional on individual GABA concentration.
Topics: Cross-Over Studies; Double-Blind Method; Frontotemporal Dementia; Frontotemporal Lobar Degeneration; | 2022 |
GABA and glutamate deficits from frontotemporal lobar degeneration are associated with disinhibition.
Topics: Aged; Aged, 80 and over; Female; Frontotemporal Lobar Degeneration; gamma-Aminobutyric Acid; Glutama | 2020 |
Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U.
Topics: Animals; Apoptosis; Atrophy; Brain; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Caspase 3; C | 2010 |