gamma-aminobutyric acid has been researched along with Epilepsy, Temporal Lobe in 182 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
Epilepsy, Temporal Lobe: A localization-related (focal) form of epilepsy characterized by recurrent seizures that arise from foci within the TEMPORAL LOBE, most commonly from its mesial aspect. A wide variety of psychic phenomena may be associated, including illusions, hallucinations, dyscognitive states, and affective experiences. The majority of complex partial seizures (see EPILEPSY, COMPLEX PARTIAL) originate from the temporal lobes. Temporal lobe seizures may be classified by etiology as cryptogenic, familial, or symptomatic. (From Adams et al., Principles of Neurology, 6th ed, p321).
| Excerpt | Relevance | Reference |
|---|---|---|
| " The present study evaluated the distribution pattern of GABAergic interneurons, especially parvalbumin (PV)- and somatostatin (SS)-immunopositive neurons, and excitatory propagation pattern in the IC of rats 4-7 days and 2 months after pilocarpine-induced status epilepticus (4-7 d and 2 m post-SE rats, respectively)." | 7.76 | Pilocarpine-induced status epilepticus causes acute interneuron loss and hyper-excitatory propagation in rat insular cortex. ( Chen, S; Fujita, S; Kobayashi, M; Koshikawa, N, 2010) |
| "Several similarities exist between the alterations observed in the chronic pilocarpine model of recurrent seizures in the rat and those found in human temporal lobe epilepsy." | 7.69 | Vulnerability and plasticity of the GABA system in the pilocarpine model of spontaneous recurrent seizures. ( Esclapez, M; Houser, CR, 1996) |
| "Vigabatrin (VGB) is a new antiepileptic drug that increases the human brain gamma-aminobutyric acid (GABA) level by irreversibly inhibiting GABA transaminase." | 6.70 | Effects of vigabatrin on brain GABA+/CR signals in patients with epilepsy monitored by 1H-NMR-spectroscopy: responder characteristics. ( Boesiger, P; Duc, CO; Meier, D; Mueller, SG; Russ, W; Weber, B; Weber, OM; Wieser, HG, 2001) |
| " The present study evaluated the distribution pattern of GABAergic interneurons, especially parvalbumin (PV)- and somatostatin (SS)-immunopositive neurons, and excitatory propagation pattern in the IC of rats 4-7 days and 2 months after pilocarpine-induced status epilepticus (4-7 d and 2 m post-SE rats, respectively)." | 3.76 | Pilocarpine-induced status epilepticus causes acute interneuron loss and hyper-excitatory propagation in rat insular cortex. ( Chen, S; Fujita, S; Kobayashi, M; Koshikawa, N, 2010) |
| " Stereological techniques were used to estimate numbers of gephyrin-positive punctae in the dentate gyrus, which were reduced short-term (5 days after pilocarpine-induced status epilepticus) but later rebounded beyond controls in epileptic rats." | 3.76 | Initial loss but later excess of GABAergic synapses with dentate granule cells in a rat model of temporal lobe epilepsy. ( Buckmaster, PS; Phanwar, I; Thind, KK; Wen, X; Yamawaki, R; Zhang, G, 2010) |
| "To determine whether a pharmacologic treatment could delay or prevent the epileptogenesis induced by status epilepticus (SE) through the protection of some brain areas, we studied the effects of the long-term exposure to pregabalin (PGB) on neuronal damage and epileptogenesis induced by lithium-pilocarpine SE." | 3.72 | Long-term pregabalin treatment protects basal cortices and delays the occurrence of spontaneous seizures in the lithium-pilocarpine model in the rat. ( André, V; Ferrandon, A; Koning, E; Nehlig, A; Rigoulot, MA, 2003) |
| " The second patient complained of impotence after a rash while taking phenytoin and carbamazepine." | 3.70 | Improved sexual function in three men taking lamotrigine for epilepsy. ( Carwile, ST; Husain, AM; Miller, PP; Radtke, RA, 2000) |
| "Several similarities exist between the alterations observed in the chronic pilocarpine model of recurrent seizures in the rat and those found in human temporal lobe epilepsy." | 3.69 | Vulnerability and plasticity of the GABA system in the pilocarpine model of spontaneous recurrent seizures. ( Esclapez, M; Houser, CR, 1996) |
| "Gamma-Aminobutyric acid (GABA) has been implicated in the neurochemistry of epilepsy." | 3.66 | Low cerebrospinal fluid gamma-aminobutyric acid content in seizure patients. ( Ballenger, JC; Glaeser, BS; Hare, TA; Post, RM; Wood, JH, 1979) |
| "Temporal lobe epilepsy was associated with bilateral reduction in NAAt/Cr but not significant abnormality in GABA+/Cr or GLX/Cr." | 2.74 | Proton MR spectroscopy of metabolite concentrations in temporal lobe epilepsy and effect of temporal lobe resection. ( Barker, GJ; Duncan, JS; McLean, MA; Simister, RJ, 2009) |
| "Vigabatrin (VGB) is a new antiepileptic drug that increases the human brain gamma-aminobutyric acid (GABA) level by irreversibly inhibiting GABA transaminase." | 2.70 | Effects of vigabatrin on brain GABA+/CR signals in patients with epilepsy monitored by 1H-NMR-spectroscopy: responder characteristics. ( Boesiger, P; Duc, CO; Meier, D; Mueller, SG; Russ, W; Weber, B; Weber, OM; Wieser, HG, 2001) |
| "Epilepsy is one of the most impactful diseases on social life." | 2.47 | Temporal lobe epilepsy and anti glutamic acid decarboxylase autoimmunity. ( Errichiello, L; Striano, P; Striano, S; Zara, F, 2011) |
| "Temporal lobe epilepsy is one of the most common forms of epilepsy." | 2.43 | Axonal sprouting of GABAergic interneurons in temporal lobe epilepsy. ( Bausch, SB, 2005) |
| "The characteristic clinical history, seizure semiology, and magnetic resonance imaging findings have allowed a discrete epilepsy syndrome to be established." | 2.41 | Adolescent seizures and epilepsy syndromes. ( Kim, HL; Wheless, JW, 2002) |
| "Knowledge of these syndromes has important treatment and prognostic implications, which usually extend into adulthood." | 2.41 | Adolescent seizures and epilepsy syndromes. ( Kim, HL; Wheless, JW, 2002) |
| "The events that follow epilepsy seizures are not restricted to the immediate period." | 2.41 | Cell death and synaptic reorganizations produced by seizures. ( Ben-Ari, Y, 2001) |
| " This may be related to dosage and speed of introduction." | 2.39 | Psychotic and severe behavioural reactions with vigabatrin: a review. ( Ferrie, CD; Panayiotopoulos, CP; Robinson, RO, 1996) |
| "Mean seizure class did not differ between the treatment groups." | 1.91 | E2730, an uncompetitive γ-aminobutyric acid transporter-1 inhibitor, suppresses epileptic seizures in a rat model of chronic mesial temporal lobe epilepsy. ( Ali, I; Brady, RD; Braine, E; Casillas-Espinosa, PM; Cheng, JY; Fukushima, K; Haskali, MB; Hudson, MR; Jones, NC; Jupp, B; Kwan, P; Major, B; Mychasiuk, R; O'Brien, TJ; Sachdev, P; Shultz, SR; Silva, J; Thergarajan, P; Vivash, L; Wright, DK; Yamakawa, GR, 2023) |
| "Secondary generalized seizure (sGS) is a major source of disability in temporal lobe epilepsy (TLE) with unclear cellular/circuit mechanisms." | 1.46 | Depolarized GABAergic Signaling in Subicular Microcircuits Mediates Generalized Seizure in Temporal Lobe Epilepsy. ( Chen, B; Chen, Z; Duan, S; Gao, F; Guo, Y; Ji, C; Li, X; Liang, J; Luo, J; Wang, S; Wang, Y; Wu, X; Xu, C; Xu, Z, 2017) |
| "Using a rat model of complex febrile seizures, which are thought to be a precipitating insult of TLE later in life, we report that aberrant migration of neonatal-generated granule cells results in granule cell ectopia that persists into adulthood." | 1.38 | GABAergic excitation after febrile seizures induces ectopic granule cells and adult epilepsy. ( Ichikawa, J; Ikegaya, Y; Koyama, R; Matsuki, N; Miyamoto, D; Muramatsu, R; Sasaki, T; Tao, K, 2012) |
| "Temporal lobe epilepsy is the most common type of epilepsy in adults, and its pathophysiology remains unclear." | 1.33 | Hyperexcitability, interneurons, and loss of GABAergic synapses in entorhinal cortex in a model of temporal lobe epilepsy. ( Buckmaster, PS; Kumar, SS, 2006) |
| "Temporal lobe epilepsy is the most common type of epilepsy in adults, and its underlying mechanisms are unclear." | 1.32 | Reduced inhibition and increased output of layer II neurons in the medial entorhinal cortex in a model of temporal lobe epilepsy. ( Buckmaster, PS; Kobayashi, M; Wen, X, 2003) |
| "Gabapentin (GBP) is a commonly used drug in the treatment of partial seizures, but its mode of action is still unclear." | 1.32 | Gabapentin increases the hyperpolarization-activated cation current Ih in rat CA1 pyramidal cells. ( Feuerstein, TJ; Freiman, TM; Surges, R, 2003) |
| "Lamotrigine was added to the carbamazepine regimen; impotence improved with decrease in carbamazepine and increase in lamotrigine." | 1.31 | Improved sexual function in three men taking lamotrigine for epilepsy. ( Carwile, ST; Husain, AM; Miller, PP; Radtke, RA, 2000) |
| " After lamotrigine was added for better seizure control and the dosage of gabapentin was tapered, anorgasmia improved." | 1.31 | Improved sexual function in three men taking lamotrigine for epilepsy. ( Carwile, ST; Husain, AM; Miller, PP; Radtke, RA, 2000) |
| "The second patient complained of impotence after a rash while taking phenytoin and carbamazepine." | 1.31 | Improved sexual function in three men taking lamotrigine for epilepsy. ( Carwile, ST; Husain, AM; Miller, PP; Radtke, RA, 2000) |
| "Mesial temporal lobe epilepsy is characterized by hippocampal atrophy, hypometabolism, and decreased N-acetylaspartate, often attributed to neuron loss and gliosis." | 1.31 | Neuronal and glial metabolite content of the epileptogenic human hippocampus. ( Errante, LD; Kim, JH; Petroff, OA; Rothman, DL; Spencer, DD, 2002) |
| "Temporal lobe epilepsy is known to be associated with hyperactivity that is likely to be generated or amplified in the hippocampal formation." | 1.31 | Preservation of perisomatic inhibitory input of granule cells in the epileptic human dentate gyrus. ( Borhegyi, Z; Eross, L; Freund, TF; Halász, P; Maglóczky, Z; Szabó, Z; Tóth, S; Wittner, L, 2001) |
| "Vigabatrin has been shown to protect against hippocampal neuronal cell death in experimental models of epilepsy." | 1.29 | Treatment with antiepileptic drugs: possible neuroprotective effects. ( Pitkänen, A, 1996) |
| "The creatine content was the same in biopsied epileptic cortex (8." | 1.29 | Symbiosis between in vivo and in vitro NMR spectroscopy: the creatine, N-acetylaspartate, glutamate, and GABA content of the epileptic human brain. ( Petroff, OA; Pleban, LA; Spencer, DD, 1995) |
| "A study was conducted to assess the impact of single dosing and different dosing intervals of vigabatrin [gamma vinyl GABA (GVG)] in 11 patients with drug-resistant complex partial seizures." | 1.28 | Pharmacokinetic effects of vigabatrin on cerebrospinal fluid amino acids in humans. ( Ben-Menachem, E, 1989) |
| "Gamma-Aminobutyric acid (GABA) has been implicated in the neurochemistry of epilepsy." | 1.26 | Low cerebrospinal fluid gamma-aminobutyric acid content in seizure patients. ( Ballenger, JC; Glaeser, BS; Hare, TA; Post, RM; Wood, JH, 1979) |
| "Although lumbar CSF GABA levels in our seizure patients did not significantly correlate with serum concentrations of phenytoin, phenobarbital, or primidone, additional study of medication-free epileptic patients may be required to evaluate the possibility of anticonvulsant-drug-induced CSF GABA alterations." | 1.26 | Low cerebrospinal fluid gamma-aminobutyric acid content in seizure patients. ( Ballenger, JC; Glaeser, BS; Hare, TA; Post, RM; Wood, JH, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (7.69) | 18.7374 |
| 1990's | 31 (17.03) | 18.2507 |
| 2000's | 83 (45.60) | 29.6817 |
| 2010's | 41 (22.53) | 24.3611 |
| 2020's | 13 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Gurrell, R | 1 |
| Iredale, P | 1 |
| Evrard, A | 1 |
| Duveau, V | 1 |
| Ruggiero, C | 1 |
| Roucard, C | 1 |
| Avoli, M | 6 |
| de Curtis, M | 2 |
| Lévesque, M | 1 |
| Librizzi, L | 1 |
| Uva, L | 1 |
| Wang, S | 3 |
| Stieve, BJ | 1 |
| Smith, MM | 1 |
| Krook-Magnuson, E | 1 |
| Ali, I | 1 |
| Silva, J | 1 |
| Casillas-Espinosa, PM | 1 |
| Braine, E | 1 |
| Yamakawa, GR | 1 |
| Hudson, MR | 1 |
| Brady, RD | 1 |
| Major, B | 1 |
| Thergarajan, P | 1 |
| Haskali, MB | 1 |
| Wright, DK | 1 |
| Jupp, B | 1 |
| Vivash, L | 1 |
| Shultz, SR | 1 |
| Mychasiuk, R | 1 |
| Kwan, P | 2 |
| Jones, NC | 1 |
| Fukushima, K | 1 |
| Sachdev, P | 1 |
| Cheng, JY | 1 |
| O'Brien, TJ | 2 |
| Ruffolo, G | 1 |
| Martinello, K | 2 |
| Labate, A | 1 |
| Cifelli, P | 1 |
| Fucile, S | 2 |
| Di Gennaro, G | 4 |
| Quattrone, A | 1 |
| Esposito, V | 6 |
| Limatola, C | 1 |
| Giangaspero, F | 3 |
| Aronica, E | 2 |
| Palma, E | 7 |
| Gambardella, A | 1 |
| Dai, Y | 1 |
| Song, Y | 2 |
| Xie, J | 1 |
| Xiao, G | 1 |
| Li, X | 2 |
| Li, Z | 2 |
| Gao, F | 2 |
| Zhang, Y | 1 |
| He, E | 1 |
| Xu, S | 1 |
| Wang, Y | 3 |
| Zheng, W | 1 |
| Jiang, X | 1 |
| Qi, Z | 1 |
| Meng, D | 1 |
| Fan, Z | 1 |
| Cai, X | 1 |
| Gonen, OM | 1 |
| Moffat, BA | 1 |
| Desmond, PM | 1 |
| Lui, E | 1 |
| Hamelin, S | 1 |
| Stupar, V | 1 |
| Mazière, L | 1 |
| Guo, J | 1 |
| Labriji, W | 1 |
| Liu, C | 1 |
| Bretagnolle, L | 1 |
| Parrot, S | 1 |
| Barbier, EL | 1 |
| Depaulis, A | 1 |
| Fauvelle, F | 1 |
| He, C | 1 |
| Liu, P | 1 |
| Wu, Y | 1 |
| Chen, H | 1 |
| Yin, J | 1 |
| Zhang, T | 1 |
| Yu, F | 1 |
| Xu, H | 1 |
| Chen, M | 1 |
| Chen, X | 1 |
| Guo, L | 1 |
| Zhou, C | 1 |
| Xu, Y | 1 |
| Wang, F | 1 |
| Yu, J | 1 |
| Wu, B | 1 |
| Lybrand, ZR | 1 |
| Goswami, S | 1 |
| Zhu, J | 1 |
| Jarzabek, V | 1 |
| Merlock, N | 1 |
| Aktar, M | 1 |
| Smith, C | 1 |
| Zhang, L | 1 |
| Varma, P | 1 |
| Cho, KO | 1 |
| Ge, S | 1 |
| Hsieh, J | 1 |
| Ren, E | 1 |
| Curia, G | 1 |
| Gu, Y | 1 |
| Wu, H | 1 |
| Wang, T | 1 |
| Yu, S | 1 |
| Han, Z | 1 |
| Zhang, W | 1 |
| Mu, L | 1 |
| Wang, H | 2 |
| Na, M | 1 |
| Lin, Z | 1 |
| Xu, C | 1 |
| Xu, Z | 1 |
| Ji, C | 1 |
| Liang, J | 1 |
| Chen, B | 1 |
| Wu, X | 1 |
| Guo, Y | 1 |
| Luo, J | 1 |
| Duan, S | 1 |
| Chen, Z | 2 |
| Androsova, G | 1 |
| Krause, R | 1 |
| Borghei, M | 1 |
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| Avbersek, A | 1 |
| Becker, F | 1 |
| Berghuis, B | 1 |
| Campbell, E | 1 |
| Coppola, A | 1 |
| Francis, B | 1 |
| Wolking, S | 1 |
| Cavalleri, GL | 1 |
| Craig, J | 1 |
| Delanty, N | 2 |
| Koeleman, BPC | 1 |
| Kunz, WS | 1 |
| Lerche, H | 1 |
| Marson, AG | 1 |
| Sander, JW | 1 |
| Sills, GJ | 1 |
| Striano, P | 2 |
| Zara, F | 2 |
| Sisodiya, SM | 1 |
| Depondt, C | 1 |
| Subramanian, D | 1 |
| Pralong, E | 1 |
| Daniel, RT | 1 |
| Chacko, AG | 1 |
| Stoop, R | 1 |
| Babu, KS | 1 |
| Xu, K | 2 |
| Liu, Z | 1 |
| Wang, L | 2 |
| Wu, G | 2 |
| Liu, T | 1 |
| Liu, F | 1 |
| Xu, W | 1 |
| Liu, J | 1 |
| Chen, S | 2 |
| Chun, E | 1 |
| Bumanglag, AV | 1 |
| Burke, SN | 1 |
| Sloviter, RS | 2 |
| Du, R | 1 |
| Zhu, X | 1 |
| Wu, S | 1 |
| Zhang, X | 1 |
| He, Y | 1 |
| Zhang, K | 1 |
| He, X | 1 |
| Wang, X | 1 |
| Sun, Y | 1 |
| Wang, Q | 1 |
| Zhang, H | 1 |
| Tian, M | 1 |
| Li, ZX | 1 |
| Yu, HM | 1 |
| Jiang, KW | 1 |
| Sun, C | 3 |
| Sun, J | 1 |
| Erisir, A | 2 |
| Kapur, J | 5 |
| Grosser, S | 1 |
| Queenan, BN | 1 |
| Lalchandani, RR | 1 |
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| Soukupová, M | 1 |
| Binaschi, A | 1 |
| Falcicchia, C | 1 |
| Zucchini, S | 1 |
| Roncon, P | 1 |
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| Simonato, M | 2 |
| Lee, H | 1 |
| Yun, S | 1 |
| Kim, IS | 1 |
| Lee, IS | 1 |
| Shin, JE | 1 |
| Park, SC | 1 |
| Kim, WJ | 1 |
| Park, KI | 1 |
| Grabenstatter, HL | 1 |
| Cogswell, M | 1 |
| Cruz Del Angel, Y | 1 |
| Carlsen, J | 1 |
| Gonzalez, MI | 1 |
| Raol, YH | 1 |
| Russek, SJ | 1 |
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| Eftekhari, S | 1 |
| Mehrabi, S | 1 |
| Soleimani, M | 1 |
| Hassanzadeh, G | 1 |
| Shahrokhi, A | 1 |
| Mostafavi, H | 1 |
| Hayat, P | 1 |
| Barati, M | 1 |
| Mehdizadeh, H | 1 |
| Rahmanzadeh, R | 1 |
| Hadjighassem, MR | 1 |
| Joghataei, MT | 1 |
| Nugent, AC | 1 |
| Martinez, A | 1 |
| D'Alfonso, A | 1 |
| Zarate, CA | 1 |
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| Lee, SH | 1 |
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| You, Z | 1 |
| Li, M | 1 |
| Pang, L | 1 |
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| Bethmann, K | 1 |
| Fritschy, JM | 4 |
| Brandt, C | 1 |
| Löscher, W | 2 |
| Simister, RJ | 1 |
| McLean, MA | 1 |
| Barker, GJ | 1 |
| Duncan, JS | 3 |
| Eichler, SA | 1 |
| Kirischuk, S | 1 |
| Jüttner, R | 1 |
| Schaefermeier, PK | 1 |
| Schafermeier, PK | 1 |
| Legendre, P | 1 |
| Lehmann, TN | 2 |
| Gloveli, T | 1 |
| Grantyn, R | 1 |
| Meier, JC | 1 |
| Thompson, K | 1 |
| Teichgräber, LA | 1 |
| Meencke, HJ | 1 |
| Weiss, T | 1 |
| Nitsch, R | 2 |
| Deisz, RA | 1 |
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| Cano Ruiz, A | 1 |
| Gobernado Serrano, JM | 1 |
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| Milicua Salamero, JM | 1 |
| Wittner, L | 3 |
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| Clémenceau, S | 3 |
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| Dezamis, E | 1 |
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| Baulac, M | 3 |
| Freund, TF | 3 |
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| Miles, R | 4 |
| Sperk, G | 3 |
| Drexel, M | 2 |
| Pirker, S | 2 |
| Kücker, S | 1 |
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| Gernert, M | 2 |
| Fujita, S | 1 |
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| Kobayashi, M | 2 |
| Thind, KK | 2 |
| Yamawaki, R | 3 |
| Phanwar, I | 1 |
| Zhang, G | 1 |
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| Buckmaster, PS | 6 |
| Kim, YB | 1 |
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| Cichon, S | 1 |
| Sander, T | 1 |
| Schoch, S | 1 |
| Becker, AJ | 1 |
| Maisano, X | 1 |
| Litvina, E | 1 |
| Tagliatela, S | 1 |
| Aaron, GB | 1 |
| Grabel, LB | 1 |
| Naegele, JR | 1 |
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| Walker, MC | 1 |
| Köhling, R | 2 |
| Koyama, R | 1 |
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| Sasaki, T | 1 |
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| Miyamoto, D | 1 |
| Muramatsu, R | 1 |
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| Ikegaya, Y | 1 |
| van der Hel, WS | 1 |
| van Eijsden, P | 1 |
| Bos, IW | 1 |
| de Graaf, RA | 1 |
| Behar, KL | 2 |
| van Nieuwenhuizen, O | 1 |
| de Graan, PN | 4 |
| Braun, KP | 1 |
| Sun, FJ | 1 |
| Guo, W | 1 |
| Zheng, DH | 1 |
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| Cavalheiro, EA | 1 |
| Spreafico, R | 2 |
| Petroff, OA | 3 |
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| Margineanu, DG | 1 |
| Neder, L | 1 |
| Valente, V | 1 |
| Carlotti, CG | 1 |
| Leite, JP | 2 |
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| Paçó-Larson, ML | 1 |
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| Thomas, PM | 3 |
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| O'Connor, WT | 3 |
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| Esclapez, M | 6 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A 57-Week, Multicenter, Active-treatment, Open-label Extension Trial of CVL-865 as Adjunctive Therapy in Adults With Drug-Resistant Focal Onset Seizures[NCT04686786] | Phase 2 | 120 participants (Anticipated) | Interventional | 2020-12-08 | Enrolling by invitation | ||
| A Randomized, Double-blind, Placebo-controlled, Parallel Group, Multicenter Trial of CVL-865 as Adjunctive Therapy in Adults With Drug-Resistant Focal Onset Seizures (REALIZE Trial)[NCT04244175] | Phase 2 | 150 participants (Anticipated) | Interventional | 2020-01-27 | Recruiting | ||
| Quantitative MRI and GABA Spectroscopy to Localize the Epileptic Zone[NCT06057233] | 40 participants (Anticipated) | Observational | 2024-03-31 | Not yet recruiting | |||
| GABA/Glutamate Balance in Temporal Lobe Epilepsy With and Without Major Depression[NCT00931619] | 29 participants (Actual) | Observational | 2009-06-29 | Completed | |||
| The BrainDrugs-Epilepsy Study: A Prospective Open-label Cohort Precision Medicine Study in Epilepsy[NCT05450822] | 550 participants (Anticipated) | Observational | 2022-02-18 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
32 reviews available for gamma-aminobutyric acid and Epilepsy, Temporal Lobe
| Article | Year |
|---|---|
GABA
Topics: Animals; Electroencephalography; Epilepsies, Partial; Epilepsy; Epilepsy, Temporal Lobe; gamma-Amino | 2022 |
Synaptic Reshaping and Neuronal Outcomes in the Temporal Lobe Epilepsy.
Topics: Animals; Astrocytes; Disease Susceptibility; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Gluta | 2021 |
Tonic GABA inhibition in hippocampal dentate granule cells: its regulation and function in temporal lobe epilepsies.
Topics: Animals; Cytoplasmic Granules; Dentate Gyrus; Epilepsy, Temporal Lobe; Excitatory Amino Acid Antagon | 2013 |
Transplantation of GABA-producing cells for seizure control in models of temporal lobe epilepsy.
Topics: Animals; Brain Tissue Transplantation; Disease Models, Animal; Epilepsy, Temporal Lobe; gamma-Aminob | 2009 |
[Anticonvulsant hypersensitivity syndrome: an entity to be remembered].
Topics: Adolescent; Amines; Anemia, Hemolytic; Anticonvulsants; Astrocytoma; Brain Neoplasms; Carbamazepine; | 2009 |
Neuronal plasticity in animal models and the epileptic human hippocampus.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; gamma-Aminobutyri | 2009 |
Temporal lobe epilepsy and anti glutamic acid decarboxylase autoimmunity.
Topics: Animals; Antibodies; Autoimmune Diseases; Autoimmunity; Epilepsy; Epilepsy, Temporal Lobe; gamma-Ami | 2011 |
GABAergic transmission in temporal lobe epilepsy: the role of neurosteroids.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Humans; Ne | 2013 |
Tonic GABA(A) receptor-mediated signalling in temporal lobe epilepsy.
Topics: Animals; Electrophysiology; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Humans; Neural Inhibit | 2013 |
Does interictal synchronization influence ictogenesis?
Topics: Animals; Disease Models, Animal; Electroencephalography Phase Synchronization; Epilepsy, Temporal Lo | 2013 |
Mesial temporal lobe epilepsy: a pathological replay of developmental mechanisms?
Topics: Animals; Brain; Chlorides; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; gamma-Aminobut | 2003 |
Dogma and dreams: experimental lessons for epilepsy mechanism chasers.
Topics: Adult; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Humans; Neural Inhibition; Synaptic Transmi | 2005 |
Axonal sprouting of GABAergic interneurons in temporal lobe epilepsy.
Topics: Axons; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Humans; Interneurons | 2005 |
Mechanisms regulating GABAergic inhibitory transmission in the basolateral amygdala: implications for epilepsy and anxiety disorders.
Topics: Adrenergic alpha-Agonists; Amygdala; Animals; Anticonvulsants; Anxiety Disorders; Depression; Dose-R | 2007 |
Cell therapy in models for temporal lobe epilepsy.
Topics: Acetylcholine; Adenosine; Animals; Cell Transplantation; Disease Models, Animal; Epilepsy, Temporal | 2007 |
Seizures beget seizures: the quest for GABA as a key player.
Topics: Animals; Epilepsy; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Hippocampus; Humans; Nerve Net; | 2006 |
[The neurochemical mechanisms of temporal lobe epilepsy: an update].
Topics: Animals; Calcium Channels; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Glutamic Acid; Humans; | 2007 |
[Relevance of basic research to clinical data: Good answers, wrong questions!].
Topics: Adult; Animals; Brain; Child; Child, Preschool; Epilepsy; Epilepsy, Temporal Lobe; gamma-Aminobutyri | 2008 |
Interictal schizophrenia-like psychoses in temporal lobe epilepsy.
Topics: Anticonvulsants; Brain; Carbamazepine; Electroencephalography; Epilepsy, Temporal Lobe; Functional L | 1983 |
Magnetic resonance spectroscopy.
Topics: Aspartic Acid; Brain; Creatinine; Epilepsy; Epilepsy, Complex Partial; Epilepsy, Temporal Lobe; gamm | 1996 |
Psychotic and severe behavioural reactions with vigabatrin: a review.
Topics: Adult; Anticonvulsants; Child; Contraindications; Dose-Response Relationship, Drug; Epilepsy; Epilep | 1996 |
Amygdala damage in experimental and human temporal lobe epilepsy.
Topics: Amygdala; Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Humans; | 1998 |
1H MR spectroscopy in patients with mesial temporal epilepsy.
Topics: Aspartic Acid; Choline; Creatine; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Glutamic Acid; G | 1998 |
Chandelier cells and epilepsy.
Topics: Animals; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Humans; Interneurons; Models, Neurologica | 1999 |
What is GABAergic inhibition? How is it modified in epilepsy?
Topics: Animals; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Hippocampus; Humans; Interneurons; Models | 2000 |
Kainate, a double agent that generates seizures: two decades of progress.
Topics: Animals; Disease Models, Animal; Electric Conductivity; Epilepsy, Temporal Lobe; Excitatory Amino Ac | 2000 |
Pathophysiology of epilepsy.
Topics: Adult; Animals; Anticonvulsants; Autoimmune Diseases; Calcium; Catecholamines; Cell Movement; Child; | 2000 |
The process of epileptogenesis: a pathophysiological approach.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Glutamic Acid; Hi | 2001 |
Cell death and synaptic reorganizations produced by seizures.
Topics: Animals; Cell Death; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Hippocampus; Humans; In Vitro | 2001 |
Adolescent seizures and epilepsy syndromes.
Topics: Adolescent; Age Factors; Brain; Child; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; Es | 2002 |
Sodium valproate: a review of its pharmacological properties and therapeutic efficacy in epilepsy.
Topics: Administration, Oral; Adult; Animals; Anticonvulsants; Behavior; Blood Platelets; Child; Clinical Tr | 1977 |
Neuron-glia relationships in human and experimental epilepsy: a biochemical point of view.
Topics: Amino Acids; Animals; Biological Transport; Brain; Carbonic Anhydrases; Epilepsy; Epilepsy, Temporal | 1986 |
6 trials available for gamma-aminobutyric acid and Epilepsy, Temporal Lobe
| Article | Year |
|---|---|
Proton MR spectroscopy of metabolite concentrations in temporal lobe epilepsy and effect of temporal lobe resection.
Topics: Adolescent; Adult; Aspartic Acid; Brain Chemistry; Brain Mapping; Carnosine; Creatine; Epilepsy, Tem | 2009 |
Elevated extracellular levels of glutamate, aspartate and gamma-aminobutyric acid within the intraoperative, spontaneously epileptiform human hippocampus.
Topics: Adult; Anesthesia, General; Aspartic Acid; Electroencephalography; Epilepsy, Temporal Lobe; Female; | 2003 |
Progabide as an add-on drug for epilepsy refractory to high dose antiepileptic drug therapy.
Topics: Adult; Aged; Anticonvulsants; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combinati | 1984 |
Effects of vigabatrin on brain GABA+/CR signals in patients with epilepsy monitored by 1H-NMR-spectroscopy: responder characteristics.
Topics: Adolescent; Adult; Anticonvulsants; Brain; Brain Chemistry; Carnosine; Creatine; Epilepsy; Epilepsy, | 2001 |
Sodium valproate: a review of its pharmacological properties and therapeutic efficacy in epilepsy.
Topics: Administration, Oral; Adult; Animals; Anticonvulsants; Behavior; Blood Platelets; Child; Clinical Tr | 1977 |
Preliminary observations on the activity of progabide, administered as monotherapy in complex partial seizures.
Topics: Adolescent; Adult; Clinical Trials as Topic; Drug Administration Schedule; Epilepsy, Temporal Lobe; | 1988 |
145 other studies available for gamma-aminobutyric acid and Epilepsy, Temporal Lobe
| Article | Year |
|---|---|
Pronounced antiseizure activity of the subtype-selective GABA
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistant Epilepsy; Electroencephal | 2022 |
Pronounced antiseizure activity of the subtype-selective GABA
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistant Epilepsy; Electroencephal | 2022 |
Pronounced antiseizure activity of the subtype-selective GABA
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistant Epilepsy; Electroencephal | 2022 |
Pronounced antiseizure activity of the subtype-selective GABA
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistant Epilepsy; Electroencephal | 2022 |
LINCs Are Vulnerable to Epileptic Insult and Fail to Provide Seizure Control via On-Demand Activation.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Female; gamma-Aminobutyric Acid; | 2023 |
E2730, an uncompetitive γ-aminobutyric acid transporter-1 inhibitor, suppresses epileptic seizures in a rat model of chronic mesial temporal lobe epilepsy.
Topics: Adult; Animals; Disease Models, Animal; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; g | 2023 |
Modulation of GABAergic dysfunction due to SCN1A mutation linked to Hippocampal Sclerosis.
Topics: Adult; Anterior Temporal Lobectomy; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Hippocampus; H | 2020 |
CB1-Antibody Modified Liposomes for Targeted Modulation of Epileptiform Activities Synchronously Detected by Microelectrode Arrays.
Topics: Animals; Antibodies; Coordination Complexes; Disease Models, Animal; Epilepsy, Temporal Lobe; gamma- | 2020 |
Seven-tesla quantitative magnetic resonance spectroscopy of glutamate, γ-aminobutyric acid, and glutathione in the posterior cingulate cortex/precuneus in patients with epilepsy.
Topics: Adult; Aged; Case-Control Studies; Epilepsy; Epilepsy, Generalized; Epilepsy, Temporal Lobe; gamma-A | 2020 |
In vivo γ-aminobutyric acid increase as a biomarker of the epileptogenic zone: An unbiased metabolomics approach.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Electrophoresis, Capillary; Epileps | 2021 |
Gamma-aminobutyric acid (GABA) changes in the hippocampus and anterior cingulate cortex in patients with temporal lobe epilepsy.
Topics: Aspartic Acid; Choline; Creatine; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Gyrus Cinguli; H | 2021 |
Dysregulation of REV-ERBα impairs GABAergic function and promotes epileptic seizures in preclinical models.
Topics: Acute Disease; Animals; Basic-Leucine Zipper Transcription Factors; Chronic Disease; Disease Models, | 2021 |
A critical period of neuronal activity results in aberrant neurogenesis rewiring hippocampal circuitry in a mouse model of epilepsy.
Topics: Animals; Calcium; Clozapine; Disease Models, Animal; Electroencephalography; Epilepsy; Epilepsy, Tem | 2021 |
Profiling Analysis of Circular RNA and mRNA in Human Temporal Lobe Epilepsy with Hippocampal Sclerosis ILAE Type 1.
Topics: Centromere Protein A; Chloride Channels; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Gliosis; | 2022 |
Depolarized GABAergic Signaling in Subicular Microcircuits Mediates Generalized Seizure in Temporal Lobe Epilepsy.
Topics: Adolescent; Adult; Animals; Case-Control Studies; Disease Models, Animal; Electroencephalography; Ep | 2017 |
Comparative effectiveness of antiepileptic drugs in patients with mesial temporal lobe epilepsy with hippocampal sclerosis.
Topics: Adolescent; Adult; Aged; Amines; Anticonvulsants; Ataxia; Benzodiazepines; Carbamazepine; Clobazam; | 2017 |
Gamma oscillatory activity in vitro: a model system to assess pathophysiological mechanisms of comorbidity between autism and epilepsy.
Topics: Animals; Autism Spectrum Disorder; Comorbidity; Electric Stimulation; Electroencephalography; Epilep | 2018 |
Influence of hippocampal low-frequency stimulation on GABA
Topics: Amygdala; Animals; Brain-Derived Neurotrophic Factor; Cyclic AMP Response Element Modulator; Disease | 2018 |
Transplanting GABAergic Neurons Differentiated from Neural Stem Cells into Hippocampus Inhibits Seizures and Epileptiform Discharges in Pilocarpine-Induced Temporal Lobe Epilepsy Model.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Drug Resistant Epilepsy; Electroencephalography; | 2019 |
Targeted hippocampal GABA neuron ablation by Stable Substance P-saporin causes hippocampal sclerosis and chronic epilepsy in rats.
Topics: Animals; Chronic Disease; Dentate Gyrus; Epilepsy, Temporal Lobe; GABAergic Neurons; gamma-Aminobuty | 2019 |
PET imaging of metabolic changes after neural stem cells and GABA progenitor cells transplantation in a rat model of temporal lobe epilepsy.
Topics: Animals; Cell Line; Electroencephalography; Electrophysiology; Epilepsy, Temporal Lobe; Fluorodeoxyg | 2019 |
Loss of cholecystokinin-containing terminals in temporal lobe epilepsy.
Topics: Animals; Cholecystokinin; Dentate Gyrus; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Inhibitor | 2014 |
Hilar somatostatin interneurons contribute to synchronized GABA activity in an in vitro epilepsy model.
Topics: 4-Aminopyridine; Action Potentials; Animals; Calcium; Epilepsy, Temporal Lobe; gamma-Aminobutyric Ac | 2014 |
Impairment of GABA release in the hippocampus at the time of the first spontaneous seizure in the pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Calcium; Disease Models, Animal; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Hippocam | 2014 |
Human fetal brain-derived neural stem/progenitor cells grafted into the adult epileptic brain restrain seizures in rat models of temporal lobe epilepsy.
Topics: Analysis of Variance; Animals; Blotting, Western; Brain; Cell Differentiation; Chromatography, High | 2014 |
Effect of spontaneous seizures on GABAA receptor α4 subunit expression in an animal model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Pilocarpine; Rats | 2014 |
BDNF modifies hippocampal KCC2 and NKCC1 expression in a temporal lobe epilepsy model.
Topics: Animals; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Epilepsy, Temporal Lobe; gamma-A | 2014 |
The relationship between glucose metabolism, resting-state fMRI BOLD signal, and GABAA-binding potential: a preliminary study in healthy subjects and those with temporal lobe epilepsy.
Topics: Adult; Brain; Brain Mapping; Epilepsy, Temporal Lobe; Female; gamma-Aminobutyric Acid; Glucose; Glut | 2015 |
Involvement of chondroitin 6-sulfation in temporal lobe epilepsy.
Topics: Animals; Carbohydrate Sulfotransferases; Cerebral Cortex; Disease Models, Animal; Epilepsy, Temporal | 2015 |
Target-selectivity of parvalbumin-positive interneurons in layer II of medial entorhinal cortex in normal and epileptic animals.
Topics: Animals; Calbindins; Cell Adhesion Molecules, Neuronal; Cholecystokinin; Disease Models, Animal; Ent | 2016 |
Protective Effect of Resveratrol on the Brain in a Rat Model of Epilepsy.
Topics: Animals; Anticonvulsants; CA1 Region, Hippocampal; Disease Models, Animal; Down-Regulation; Epilepsy | 2017 |
Antiepileptic drug resistant rats differ from drug responsive rats in GABA A receptor subunit expression in a model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Dentate Gyrus; Disease Models, Animal; Drug Resistance; Electric Stimulati | 2008 |
Glycinergic tonic inhibition of hippocampal neurons with depolarizing GABAergic transmission elicits histopathological signs of temporal lobe epilepsy.
Topics: Action Potentials; Adult; Animals; Calcium Signaling; Chlorides; Dendrites; Epilepsy, Temporal Lobe; | 2008 |
Impaired function of GABA(B) receptors in tissues from pharmacoresistant epilepsy patients.
Topics: Animals; Anticonvulsants; Baclofen; Bicuculline; Cerebral Cortex; Drug Resistance; Epilepsy; Epileps | 2009 |
The epileptic human hippocampal cornu ammonis 2 region generates spontaneous interictal-like activity in vitro.
Topics: Action Potentials; Adult; Animals; CA2 Region, Hippocampal; Cell Shape; Chlorides; Electrophysiology | 2009 |
Kindling as a model of temporal lobe epilepsy induces bilateral changes in spontaneous striatal activity.
Topics: Action Potentials; Amygdala; Animals; Corpus Striatum; Disease Models, Animal; Epilepsy, Temporal Lo | 2010 |
Pilocarpine-induced status epilepticus causes acute interneuron loss and hyper-excitatory propagation in rat insular cortex.
Topics: Animals; Biomarkers; Cell Count; Cerebral Cortex; Convulsants; Disease Models, Animal; Electric Stim | 2010 |
Initial loss but later excess of GABAergic synapses with dentate granule cells in a rat model of temporal lobe epilepsy.
Topics: Animals; Cell Count; Convulsants; Dendritic Spines; Dentate Gyrus; Disease Models, Animal; Epilepsy, | 2010 |
Midkine, heparin-binding growth factor, blocks kainic acid-induced seizure and neuronal cell death in mouse hippocampus.
Topics: Animals; Anticonvulsants; Astrocytes; Biomarkers; Cell Death; Cytokines; Disease Models, Animal; Epi | 2010 |
Selective changes in inhibition as determinants for limited hyperexcitability in the insular cortex of epileptic rats.
Topics: Action Potentials; Animals; Disease Models, Animal; Electrophysiology; Epilepsy, Temporal Lobe; gamm | 2010 |
Selective reduction of cholecystokinin-positive basket cell innervation in a model of temporal lobe epilepsy.
Topics: Animals; CA1 Region, Hippocampal; Cholecystokinin; Disease Models, Animal; Epilepsy, Temporal Lobe; | 2010 |
Receptors with low affinity for neurosteroids and GABA contribute to tonic inhibition of granule cells in epileptic animals.
Topics: Action Potentials; Affinity Labels; Animals; Blotting, Western; Dentate Gyrus; Disease Models, Anima | 2010 |
Pancreatitis-associated protein-I and pancreatitis-associated protein-III expression in a rat model of kainic acid-induced seizure.
Topics: Aminopeptidases; Animals; Antigens, Neoplasm; Biomarkers, Tumor; Disease Models, Animal; Epilepsy, T | 2011 |
Time-domain features of epileptic spikes as potential bio-markers of the epileptogenesis process.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biomarkers; Co | 2010 |
Ultrastructural GABA immunocytochemistry in the mossy fiber terminals of Wistar and genetic absence epileptic rats receiving amygdaloid kindling stimulations.
Topics: Amygdala; Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy, Absence; Epilepsy, Temporal Lobe | 2011 |
Increased GABAergic inhibition in the midline thalamus affects signaling and seizure spread in the hippocampus-prefrontal cortex pathway.
Topics: Animals; Electric Stimulation; Electroencephalography; Epilepsy, Temporal Lobe; Evoked Potentials; G | 2011 |
Glutamate decarboxylase 67 is expressed in hippocampal mossy fibers of temporal lobe epilepsy patients.
Topics: Adolescent; Adult; Aged; Animals; Child; Dentate Gyrus; Dynorphins; Epilepsy, Temporal Lobe; Female; | 2012 |
Reduced astrocytic contribution to the turnover of glutamate, glutamine, and GABA characterizes the latent phase in the kainate model of temporal lobe epilepsy.
Topics: Amino Acids; Animals; Astrocytes; Carbon Isotopes; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; | 2011 |
Functional changes in the septal GABAergic system of animals with a model of temporal lobe epilepsy.
Topics: Animals; Brain; Disease Models, Animal; Electrophysiology; Epilepsy, Temporal Lobe; gamma-Aminobutyr | 2011 |
Promoter variants determine γ-aminobutyric acid homeostasis-related gene transcription in human epileptic hippocampi.
Topics: Alleles; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Genotype; Hippocampus; Humans; Polymorphi | 2011 |
Differentiation and functional incorporation of embryonic stem cell-derived GABAergic interneurons in the dentate gyrus of mice with temporal lobe epilepsy.
Topics: Animals; Cell Line; Dentate Gyrus; Disease Models, Animal; Embryonic Stem Cells; Epilepsy, Temporal | 2012 |
GABAergic excitation after febrile seizures induces ectopic granule cells and adult epilepsy.
Topics: Animals; Animals, Suckling; Brain Diseases; Bumetanide; Cell Lineage; Cell Movement; Choristoma; Den | 2012 |
In vivo MRS and histochemistry of status epilepticus-induced hippocampal pathology in a juvenile model of temporal lobe epilepsy.
Topics: Animals; Biomarkers; Choline; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Glutamine; Hippocamp | 2013 |
Increased expression of TRPV1 in the cortex and hippocampus from patients with mesial temporal lobe epilepsy.
Topics: Adolescent; Adult; Astrocytes; Case-Control Studies; Cerebral Cortex; Dendrites; Epilepsy, Temporal | 2013 |
Axon sprouting in a model of temporal lobe epilepsy creates a predominantly excitatory feedback circuit.
Topics: Animals; Atropine Derivatives; Axons; Dendrites; Disease Models, Animal; Epilepsy, Temporal Lobe; Fe | 2002 |
Alterations of the neocortical GABAergic system in the pilocarpine model of temporal lobe epilepsy: neuronal damage and immunocytochemical changes in chronic epileptic rats.
Topics: Animals; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Immunohistochemistry; Male; Neocortex; Ne | 2002 |
Neuronal and glial metabolite content of the epileptogenic human hippocampus.
Topics: Adult; Amino Acids; Aspartic Acid; Epilepsy, Temporal Lobe; Female; gamma-Aminobutyric Acid; Glutami | 2002 |
Expression of human epileptic temporal lobe neurotransmitter receptors in Xenopus oocytes: An innovative approach to study epilepsy.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adolescent; Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolep | 2002 |
Neuroscience. GABA becomes exciting.
Topics: Action Potentials; Animals; Brain; Chlorides; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Hipp | 2002 |
On the origin of interictal activity in human temporal lobe epilepsy in vitro.
Topics: Action Potentials; Adult; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Ant | 2002 |
Gabapentin increases the hyperpolarization-activated cation current Ih in rat CA1 pyramidal cells.
Topics: Acetates; Amines; Animals; Anticonvulsants; Cations; Cyclic AMP; Cyclohexanecarboxylic Acids; Dose-R | 2003 |
Electrophysiological, neurochemical and regional effects of levetiracetam in the rat pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Aspartic Acid; Clonazepam; Electroencephalography; Epilepsy, Temporal Lobe | 2003 |
Glutamate NMDA receptor subunit R1 and GAD mRNA expression in human temporal lobe epilepsy.
Topics: Adult; Epilepsy, Temporal Lobe; Female; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hippocampu | 2002 |
Dentate granule cell GABA(A) receptors in epileptic hippocampus: enhanced synaptic efficacy and altered pharmacology.
Topics: Animals; Epilepsy, Temporal Lobe; Excitatory Postsynaptic Potentials; GABA Agonists; GABA Antagonist | 2003 |
Long-term pregabalin treatment protects basal cortices and delays the occurrence of spontaneous seizures in the lithium-pilocarpine model in the rat.
Topics: Animals; Anticonvulsants; Astrocytes; Brain; Cell Death; Cerebral Cortex; Convulsants; Electroenceph | 2003 |
Downregulation of the alpha5 subunit of the GABA(A) receptor in the pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Down-Regulation; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; | 2003 |
Evidence for strychnine-sensitive glycine receptors in human amygdala.
Topics: Acetylcholine; Adult; Amygdala; Animals; Blotting, Western; Chromatography, High Pressure Liquid; Ep | 2003 |
Selective changes in gamma-aminobutyric acid type A receptor subunits in the hippocampus in spontaneously seizing rats with chronic temporal lobe epilepsy.
Topics: Animals; Chronic Disease; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; gamma-Aminobuty | 2003 |
Reduced inhibition and increased output of layer II neurons in the medial entorhinal cortex in a model of temporal lobe epilepsy.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Entorhinal Cortex; Epilepsy, Temporal Lobe; gamma-Am | 2003 |
PSYCHOTIC BEHAVIOR WITH EVOKED SEPTAL DYSRHYTHMIA: EFFECTS OF INTRACEREBRAL ACETYLCHOLINE AND GAMMA AMINOBUTYRIC ACID.
Topics: Acetylcholine; Aminobutyrates; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; gamma-Amin | 1965 |
Expression of plasma membrane GABA transporters but not of the vesicular GABA transporter in dentate granule cells after kainic acid seizures.
Topics: Animals; Carrier Proteins; Cell Membrane; Dentate Gyrus; Disease Models, Animal; Epilepsy; Epilepsy, | 2003 |
Hippocampal microdialysis during spontaneous intraoperative epileptiform activity.
Topics: Adult; Aspartic Acid; Dominance, Cerebral; Electroencephalography; Epilepsy, Temporal Lobe; Female; | 2004 |
Rapid deletion of mossy cells does not result in a hyperexcitable dentate gyrus: implications for epileptogenesis.
Topics: Dentate Gyrus; Disease Models, Animal; Electric Stimulation; Epilepsy, Temporal Lobe; Excitatory Pos | 2004 |
Evaluation of GABA system and cell damage in parahippocampus of patients with temporal lobe epilepsy showing antiepileptic effects after subacute electrical stimulation.
Topics: Adult; Cell Count; Electric Stimulation Therapy; Epilepsy, Temporal Lobe; Female; gamma-Aminobutyric | 2004 |
Synaptosomal glutamate and GABA transport in patients with temporal lobe epilepsy.
Topics: Amino Acid Transport System X-AG; Animals; Biological Transport; Calcium; Carrier Proteins; Epilepsy | 2004 |
Microdialysis of the lateral and medial temporal lobe during temporal lobe epilepsy surgery.
Topics: Action Potentials; Adult; Aspartic Acid; Electroencephalography; Epilepsy, Temporal Lobe; Extracellu | 2005 |
In vitro 1H NMR spectroscopy shows an increase in N-acetylaspartylglutamate and glutamine content in the hippocampus of amygdaloid-kindled rats.
Topics: Amino Acids; Amygdala; Animals; Creatine; Dipeptides; Disease Models, Animal; Energy Metabolism; Epi | 2005 |
Temporal patterns of fos expression in the dentate gyrus after spontaneous seizures in a mouse model of temporal lobe epilepsy.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Hi | 2005 |
Rundown of GABA type A receptors is a dysfunction associated with human drug-resistant mesial temporal lobe epilepsy.
Topics: Adolescent; Adult; Aged; Animals; Anticonvulsants; Brain-Derived Neurotrophic Factor; Cell Membrane; | 2005 |
Altered inhibition in lateral amygdala networks in a rat model of temporal lobe epilepsy.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Amygdala; Animals; Disease Models, Animal; | 2006 |
Correlation of transcriptome profile with electrical activity in temporal lobe epilepsy.
Topics: Action Potentials; Adult; Down-Regulation; Electroencephalography; Epilepsy, Temporal Lobe; Female; | 2006 |
Distribution of GABAergic neurons in the striatum of amygdala-kindled rats: an immunohistochemical and in situ hybridization study.
Topics: Amygdala; Animals; Corpus Striatum; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; gamma-A | 2006 |
Hyperexcitability, interneurons, and loss of GABAergic synapses in entorhinal cortex in a model of temporal lobe epilepsy.
Topics: Action Potentials; Animals; Cells, Cultured; Disease Models, Animal; Entorhinal Cortex; Epilepsy, Te | 2006 |
Anomalous levels of Cl- transporters in the hippocampal subiculum from temporal lobe epilepsy patients make GABA excitatory.
Topics: Animals; Bumetanide; Epilepsy, Temporal Lobe; Excitatory Postsynaptic Potentials; gamma-Aminobutyric | 2006 |
Subiculum network excitability is increased in a rodent model of temporal lobe epilepsy.
Topics: Action Potentials; Animals; Biomarkers; Convulsants; Disease Models, Animal; Electric Stimulation; E | 2006 |
The selective effects of somatostatin- and GABA-mediated transmissions on voltage gated Ca2+ channel immunoreactivity in the gerbil hippocampus.
Topics: Animals; Calcium Channels; Calcium Channels, L-Type; Calcium Channels, N-Type; Calcium Channels, P-T | 2006 |
Downregulation of tonic GABA currents following epileptogenic stimulation of rat hippocampal cultures.
Topics: Animals; Animals, Newborn; Benzothiadiazines; Cells, Cultured; Epilepsy, Temporal Lobe; Excitatory A | 2006 |
Dentate development in organotypic hippocampal slice cultures from p35 knockout mice.
Topics: Animals; Astrocytes; Axons; Cell Differentiation; Cell Movement; Dendrites; Dentate Gyrus; Epilepsy, | 2007 |
omega-Conotoxin MVIIA inhibits amygdaloid kindled seizures in Sprague-Dawley rats.
Topics: Amygdala; Animals; Anticonvulsants; Brain Stem; Calcium Channel Blockers; Calcium Channels, N-Type; | 2007 |
Distinct types of ionic modulation of GABA actions in pyramidal cells and interneurons during electrical induction of hippocampal seizure-like network activity.
Topics: Action Potentials; Animals; Cell Membrane; Chloride Channels; Chlorides; Epilepsy; Epilepsy, Tempora | 2007 |
The antiepileptic drug levetiracetam stabilizes the human epileptic GABAA receptors upon repetitive activation.
Topics: Adult; Aged; Animals; Anticonvulsants; Brain Tissue Transplantation; Cell Membrane; Child; Epilepsy, | 2007 |
Perturbed chloride homeostasis and GABAergic signaling in human temporal lobe epilepsy.
Topics: Adult; Animals; Chlorides; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Homeostasis; Humans; In | 2007 |
Diminished neurosteroid sensitivity of synaptic inhibition and altered location of the alpha4 subunit of GABA(A) receptors in an animal model of epilepsy.
Topics: Animals; Benzodiazepines; Disease Models, Animal; Drug Resistance; Epilepsy, Temporal Lobe; gamma-Am | 2007 |
Epileptiform synchronization in the rat insular and perirhinal cortices in vitro.
Topics: 4-Aminopyridine; Action Potentials; Animals; Cerebral Cortex; Cortical Synchronization; Epilepsy, Te | 2007 |
GABA(A)-current rundown of temporal lobe epilepsy is associated with repetitive activation of GABA(A) "phasic" receptors.
Topics: Animals; Electrophysiology; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Humans; Male; Neurons; | 2007 |
Downregulation of the CB1 cannabinoid receptor and related molecular elements of the endocannabinoid system in epileptic human hippocampus.
Topics: Adult; Age Factors; Aged; Analysis of Variance; Cannabinoid Receptor Modulators; Carrier Proteins; C | 2008 |
Decreased hippocampal volume on MRI is associated with increased extracellular glutamate in epilepsy patients.
Topics: Adolescent; Adult; Atrophy; Chromatography, High Pressure Liquid; Electroencephalography; Epilepsy, | 2008 |
Synaptic input to dentate granule cell basal dendrites in a rat model of temporal lobe epilepsy.
Topics: Animals; Cell Shape; Convulsants; Dendrites; Dentate Gyrus; Disease Models, Animal; Epilepsy, Tempor | 2008 |
Loss of GABAergic neurons in the subiculum and its functional implications in temporal lobe epilepsy.
Topics: Animals; Biomarkers; Dendrites; Electroencephalography; Epilepsy, Temporal Lobe; gamma-Aminobutyric | 2008 |
Kindling: an animal model of complex partial epilepsy.
Topics: Amygdala; Animals; Brain; Disease Models, Animal; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; | 1984 |
Prolonged GABA responses in dentate granule cells in slices isolated from patients with temporal lobe sclerosis.
Topics: Action Potentials; Bicuculline; Dentate Gyrus; Electrophysiology; Epilepsy, Temporal Lobe; GABA Anta | 1995 |
Hippocampal GABA transporter function in temporal-lobe epilepsy.
Topics: Amygdala; Animals; Carrier Proteins; Disease Models, Animal; Epilepsy, Temporal Lobe; GABA Plasma Me | 1995 |
Analysis of macromolecule resonances in 1H NMR spectra of human brain.
Topics: Adult; Creatine; Cytosol; Epilepsy, Temporal Lobe; Female; gamma-Aminobutyric Acid; Glutamic Acid; G | 1994 |
1H magnetic resonance spectroscopy of extracts of human epileptic neocortex and hippocampus.
Topics: Adolescent; Adult; Amino Acids; Aspartic Acid; Cerebral Cortex; Child; Epilepsy, Temporal Lobe; Fema | 1993 |
Zinc-induced collapse of augmented inhibition by GABA in a temporal lobe epilepsy model.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Chlorides; Dentate Gyrus | 1996 |
Treatment with antiepileptic drugs: possible neuroprotective effects.
Topics: Animals; Anticonvulsants; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Hippocampus; Humans; Ner | 1996 |
Symbiosis between in vivo and in vitro NMR spectroscopy: the creatine, N-acetylaspartate, glutamate, and GABA content of the epileptic human brain.
Topics: Aspartic Acid; Astrocytes; Biopsy; Creatine; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Gluta | 1995 |
Vigabatrin overdose.
Topics: Adult; Anticonvulsants; Combined Modality Therapy; Drug Overdose; Epilepsy, Temporal Lobe; Female; g | 1996 |
Vulnerability and plasticity of the GABA system in the pilocarpine model of spontaneous recurrent seizures.
Topics: Animals; Antibodies, Monoclonal; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; gam | 1996 |
Changes in hippocampal circuitry after pilocarpine-induced seizures as revealed by opioid receptor distribution and activation.
Topics: Animals; Dentate Gyrus; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Male; Neural Pathways; Pil | 1997 |
Differential epilepsy-associated alterations in postsynaptic GABA(A) receptor function in dentate granule and CA1 neurons.
Topics: Animals; Clonazepam; Epilepsy, Temporal Lobe; Evoked Potentials; gamma-Aminobutyric Acid; Hippocampu | 1997 |
Vigabatrin versus carbamazepine and phenytoin in kainic acid-treated pubescent rats.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Enzyme Inhi | 1997 |
Effects of phenytoin, carbamazepine, and gabapentin on calcium channels in hippocampal granule cells from patients with temporal lobe epilepsy.
Topics: Acetates; Adult; Amines; Anticonvulsants; Calcium Channels; Carbamazepine; Cyclohexanecarboxylic Aci | 1998 |
Antiepileptic effects of tiagabine, a selective GABA uptake inhibitor, in the rat kindling model of temporal lobe epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Dose-Response Relationship, Dru | 1997 |
GABA(A) receptor function in epileptic human dentate granule cells: comparison to epileptic and control rat.
Topics: Animals; Dentate Gyrus; Epilepsy, Temporal Lobe; GABA Agonists; GABA Antagonists; gamma-Aminobutyric | 1998 |
[Drug-resistant epilepsy].
Topics: Adult; Anticonvulsants; Brain Neoplasms; Calcinosis; Carbamazepine; Diagnosis, Differential; Drug Re | 1998 |
Hippocampal GABA and glutamate transporter immunoreactivity in patients with temporal lobe epilepsy.
Topics: Adolescent; Adult; Aged; Amino Acid Transport System X-AG; ATP-Binding Cassette Transporters; Child; | 1999 |
GABAergic neurons and GABA(A)-receptors in temporal lobe epilepsy.
Topics: Animals; Dentate Gyrus; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Hippocampus; Immunoenzyme | 1999 |
Characterization of neocortical and hippocampal synaptosomes from temporal lobe epilepsy patients.
Topics: Adult; Animals; Brain Neoplasms; Calcium; Epilepsy, Temporal Lobe; Female; gamma-Aminobutyric Acid; | 1999 |
Up-regulation of GAD65 and GAD67 in remaining hippocampal GABA neurons in a model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Gene Expression R | 1999 |
Deficit of quantal release of GABA in experimental models of temporal lobe epilepsy.
Topics: Animals; Electric Conductivity; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; gamma-Amino | 1999 |
Do GABAergic circuitries play a critical role in the regulation of seizure-induced neuronal damage and synaptic reorganization in the rat hippocampus?
Topics: Afferent Pathways; Animals; Brain Chemistry; Cell Survival; Denervation; Epilepsy, Temporal Lobe; Ex | 1999 |
Improved sexual function in three men taking lamotrigine for epilepsy.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Epilepsies, Partial; | 2000 |
Glutamate and gamma-aminobutyric acid content and release of synaptosomes from temporal lobe epilepsy patients.
Topics: Animals; Calcium; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Huma | 2000 |
Viral infection of developing GABAergic neurons in a model of hippocampal disinhibition.
Topics: Animals; Central Nervous System Viral Diseases; Dentate Gyrus; Disease Models, Animal; Epilepsy, Tem | 2000 |
Inhibitory circuits in human dysplastic tissue.
Topics: Adult; Cerebral Cortex; Epilepsy, Temporal Lobe; Female; gamma-Aminobutyric Acid; Humans; Immunohist | 2000 |
Dendritic but not somatic GABAergic inhibition is decreased in experimental epilepsy.
Topics: Action Potentials; Animals; Calbindins; Dendrites; Epilepsy, Temporal Lobe; Excitatory Amino Acid An | 2001 |
GABA(B) receptor autoradiography in hippocampal sclerosis associated with human temporal lobe epilepsy.
Topics: Adult; Autoradiography; Cell Count; Epilepsy, Temporal Lobe; Female; gamma-Aminobutyric Acid; Hippoc | 2001 |
Alterations in dystrophin and utrophin expression parallel the reorganization of GABAergic synapses in a mouse model of temporal lobe epilepsy.
Topics: Animals; Carrier Proteins; Cytoskeletal Proteins; Dentate Gyrus; Dystrophin; Epilepsy, Temporal Lobe | 2001 |
Alterations of hippocampal GAbaergic system contribute to development of spontaneous recurrent seizures in the rat lithium-pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Hippocampus; Interneurons; Lithium; Neuro | 2001 |
Diminished allopregnanolone enhancement of GABA(A) receptor currents in a rat model of chronic temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Chronic Disease; Diazepam; Electric Conductivity; Epilepsy, Temporal Lobe; | 2001 |
Preservation of perisomatic inhibitory input of granule cells in the epileptic human dentate gyrus.
Topics: Adolescent; Adult; Axons; Cortical Synchronization; Dendrites; Dentate Gyrus; Epilepsy, Temporal Lob | 2001 |
GABA and L-glutamic acid release in en bloc resection slices of human hippocampus: an in vitro microdialysis study.
Topics: Adult; Amygdala; Chromatography, High Pressure Liquid; Epilepsy, Temporal Lobe; Female; gamma-Aminob | 2001 |
Spontaneous recurrent seizures and neuropathology in the chronic phase of the pilocarpine and picrotoxin model epilepsy.
Topics: Acetylcholine; Action Potentials; Aggression; Animals; Behavior, Animal; Brain; Chronic Disease; Dis | 2002 |
Axon arbors and synaptic connections of a vulnerable population of interneurons in the dentate gyrus in vivo.
Topics: Action Potentials; Animals; Cell Death; Dentate Gyrus; Epilepsy, Temporal Lobe; Female; gamma-Aminob | 2002 |
Epileptic fast activity can be explained by a model of impaired GABAergic dendritic inhibition.
Topics: Action Potentials; Biological Clocks; Dendrites; Electroencephalography; Epilepsy, Temporal Lobe; ga | 2002 |
Recurrent complex partial status epilepticus associated with tiagabine rechallenge.
Topics: Acetates; Adult; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Dose-Response | 2002 |
Low cerebrospinal fluid gamma-aminobutyric acid content in seizure patients.
Topics: Adult; Epilepsy; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Clonic; Female; gamma-Aminobutyric Acid; H | 1979 |
Cerebrospinal fluid gamma-aminobutyric acid in neurologic disease.
Topics: Aminobutyrates; Cerebrovascular Disorders; Dementia; Epilepsy, Post-Traumatic; Epilepsy, Temporal Lo | 1976 |
The dentate gyrus as a regulated gate for the propagation of epileptiform activity.
Topics: Afferent Pathways; Animals; Brain Mapping; Culture Techniques; Dendrites; Epilepsy, Temporal Lobe; g | 1992 |
Synaptic connections of seizure-sensitive neurons in the dentate gyrus.
Topics: Animals; Brain Mapping; Calcium-Binding Proteins; Chlorocebus aethiops; Cholecystokinin; Cytoplasmic | 1992 |
Permanently altered hippocampal structure, excitability, and inhibition after experimental status epilepticus in the rat: the "dormant basket cell" hypothesis and its possible relevance to temporal lobe epilepsy.
Topics: Animals; Calbindins; Disease Models, Animal; Electric Stimulation; Epilepsy, Temporal Lobe; gamma-Am | 1991 |
A GABA and glutamate immunocytochemical study of cortical neurons of temporal epilepsy in humans.
Topics: Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Humans; Immunoenzyme Te | 1990 |
Pharmacokinetic effects of vigabatrin on cerebrospinal fluid amino acids in humans.
Topics: Adult; Amino Acids; Aminocaproates; Anticonvulsants; Cerebrospinal Fluid; Epilepsy, Temporal Lobe; F | 1989 |
Intracellular electrophysiology of CA1 pyramidal neurones in slices of the kainic acid lesioned hippocampus of the rat.
Topics: Adaptation, Physiological; Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Evoked Potentia | 1986 |
Anti-seizure and anti-epileptogenic effect of gamma-vinyl gamma-aminobutyric acid in amygdaloid kindling.
Topics: Aminocaproates; Amygdala; Animals; Anticonvulsants; Electrophysiology; Epilepsy, Temporal Lobe; gamm | 1986 |
Synaptic connections of axo-axonic (chandelier) cells in human epileptic temporal cortex.
Topics: Adolescent; Axons; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Humans; Male; Microscopy, Elect | 1986 |
Metabolic, morphologic and electrophysiologic profiles of human temporal lobe foci: an attempt at correlation.
Topics: Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Hippocampus; Humans; Neural Inhibition; Neuroglia; | 1986 |