gamma-aminobutyric acid has been researched along with Encephalopathy, Toxic in 38 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Anticonvulsant effects were evaluated against seizures induced by 14 mg kg(-1) of 4-aminopyridine (4-AP) and by 110 mg kg(-1) of pentylenetetrazole (PTZ), and neurotoxicity by the rotarod test." | 7.72 | Is the interaction between felbamate and valproate against seizures induced by 4-aminopyridine and pentylenetetrazole in mice beneficial? ( Amat, G; Armijo, JA; Cuadrado, A, 2003) |
| " The most common adverse reactions (incidence ≥ 20%) with single-agent use are fatigue, nausea, and anorexia." | 5.39 | Pemetrexed-induced cellulitis: a rare toxicity in non-small cell lung cancer treatment. ( Katsenos, S; Panagou, C; Psara, A, 2013) |
| "There are two previously reported cases describing the management of pregabalin self-poisoning and one further case of management of therapeutic pregabalin accumulation." | 3.76 | Significant pregabalin toxicity managed with supportive care alone. ( Berry, DJ; Dargan, PI; Eastwood, J; Glover, G; Wood, DM, 2010) |
| " Anticonvulsant effects were evaluated against seizures induced by 14 mg kg(-1) of 4-aminopyridine (4-AP) and by 110 mg kg(-1) of pentylenetetrazole (PTZ), and neurotoxicity by the rotarod test." | 3.72 | Is the interaction between felbamate and valproate against seizures induced by 4-aminopyridine and pentylenetetrazole in mice beneficial? ( Amat, G; Armijo, JA; Cuadrado, A, 2003) |
| "This postmarketing surveillance study of lamotrigine (LTG) was performed to provide complementary data to large-scale Prescription-Event Monitoring study with a retrospective case records survey in five tertiary referral epilepsy centres in the United Kingdom." | 3.71 | Adverse event monitoring in lamotrigine patients: a pharmacoepidemiologic study in the United Kingdom. ( Mawer, GE; Sander, JW; Wong, IC, 2001) |
| " Using a double-blind, randomized, crossover design, 16 healthy volunteers were administered (in separate sessions) capsules containing placebo, 75 mg pregabalin, 150 mg pregabalin, 10 mg oxycodone, and 75 mg pregabalin combined with 10 mg oxycodone." | 2.77 | Subjective, psychomotor, and physiological effects of pregabalin alone and in combination with oxycodone in healthy volunteers. ( Coalson, DW; Paice, JA; Zacny, JP, 2012) |
| "Asterixis has been reported as a side effect of toxic and metabolic abnormalities." | 2.49 | Asterixis related to gabapentin intake: a case report and review. ( Wahba, M; Waln, O, 2013) |
| "A growing body of experimental evidence suggests that anaesthetics, by influencing GABAergic and glutaminergic neural signalling, can have adverse effects on the developing central nervous system." | 2.44 | Potentially toxic effects of anaesthetics on the developing central nervous system. ( Gascon, E; Kiss, JZ; Klauser, P; Vutskits, L, 2007) |
| " The most common adverse reactions (incidence ≥ 20%) with single-agent use are fatigue, nausea, and anorexia." | 1.39 | Pemetrexed-induced cellulitis: a rare toxicity in non-small cell lung cancer treatment. ( Katsenos, S; Panagou, C; Psara, A, 2013) |
| "Manganese (Mn) is an essential element and it acts as a cofactor for a number of enzymatic reactions, including those involved in amino acid, lipid, protein, and carbohydrate metabolism." | 1.38 | Manganese alters rat brain amino acids levels. ( Almeida, I; Aschner, M; Batoreu, MC; Marreilha dos Santos, AP; Ramos, R; Santos, D; Sidoryk-Wegrzynowicz, M, 2012) |
| "Dibromoacetonitrile (DBAN) is a disinfection by-product of water chlorination." | 1.38 | Potential protective effect of taurine against dibromoacetonitrile-induced neurotoxicity in rats. ( El-Sayeh, BM; Salem, HA; Sayed, RH, 2012) |
| " Based on initial dose-response experiment, DBAN (60 mg/kg) was administrated orally for 7 days." | 1.38 | Potential protective effect of taurine against dibromoacetonitrile-induced neurotoxicity in rats. ( El-Sayeh, BM; Salem, HA; Sayed, RH, 2012) |
| "Valproic acid (VPA) has been used for many years as a drug of choice for epilepsy and mood disorders." | 1.35 | Chronic dietary administration of valproic acid protects neurons of the rat nucleus basalis magnocellularis from ibotenic acid neurotoxicity. ( Brignani, S; Contestabile, A; Eleuteri, S; Monti, B, 2009) |
| " Its normal plasma half-life is 2 - 3 hours; dosage modifications are obligatory in renal insufficiency." | 1.35 | Drug-induced encephalopathy secondary to non renal dosing of common medications in Two dialysis patients. ( Iloanya, PC; Nye, D; Onuigbo, MA, 2009) |
| "The U." | 1.35 | Drug-induced encephalopathy secondary to non renal dosing of common medications in Two dialysis patients. ( Iloanya, PC; Nye, D; Onuigbo, MA, 2009) |
| " Following recovery, the phencyclidine dose-response curve was repeated in the fixed-interval paradigm." | 1.33 | Effects of phencyclidine on schedule-controlled responding following neurotoxic lesions of the striatum. ( Carlson, KM; Wagner, GC, 2005) |
| " Serious adverse events were assessed individually." | 1.31 | Adverse event monitoring in lamotrigine patients: a pharmacoepidemiologic study in the United Kingdom. ( Mawer, GE; Sander, JW; Wong, IC, 2001) |
| " The adverse events with LTG reported by this study were similar to those reported in the literature." | 1.31 | Adverse event monitoring in lamotrigine patients: a pharmacoepidemiologic study in the United Kingdom. ( Mawer, GE; Sander, JW; Wong, IC, 2001) |
| " Life-threatening adverse reactions were rare." | 1.31 | Adverse event monitoring in lamotrigine patients: a pharmacoepidemiologic study in the United Kingdom. ( Mawer, GE; Sander, JW; Wong, IC, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 12 (31.58) | 29.6817 |
| 2010's | 23 (60.53) | 24.3611 |
| 2020's | 3 (7.89) | 2.80 |
| Authors | Studies |
|---|---|
| Gascoigne, DA | 1 |
| Serdyukova, NA | 1 |
| Aksenov, DP | 1 |
| Yu, Y | 2 |
| Xie, D | 2 |
| Yang, Y | 2 |
| Tan, S | 2 |
| Li, H | 2 |
| Dang, Y | 2 |
| Xiang, M | 2 |
| Chen, H | 2 |
| Ali, HFH | 1 |
| El-Sayed, NM | 1 |
| Khodeer, DM | 1 |
| Ahmed, AAM | 1 |
| Hanna, PA | 1 |
| Moustafa, YMA | 1 |
| Daher, I | 1 |
| Le Dieu-Lugon, B | 1 |
| Dourmap, N | 1 |
| Lecuyer, M | 1 |
| Ramet, L | 1 |
| Gomila, C | 1 |
| Ausseil, J | 1 |
| Marret, S | 2 |
| Leroux, P | 1 |
| Roy, V | 1 |
| El Mestikawy, S | 1 |
| Daumas, S | 1 |
| Gonzalez, B | 1 |
| Leroux-Nicollet, I | 1 |
| Cleren, C | 1 |
| Ahmed-Farid, OA | 1 |
| Haredy, SA | 1 |
| Niazy, RM | 1 |
| Linhardt, RJ | 1 |
| Warda, M | 1 |
| Wahba, M | 1 |
| Waln, O | 1 |
| Li, D | 1 |
| Liu, Q | 1 |
| Jia, D | 1 |
| Dou, D | 1 |
| Wang, X | 1 |
| Kang, T | 1 |
| Liu, DC | 1 |
| Deng, XQ | 1 |
| Wang, SB | 1 |
| Quan, ZS | 1 |
| Beauvais, K | 1 |
| Disson-Dautriche, A | 1 |
| Jacquin, A | 1 |
| Antoniol, C | 1 |
| Martin, ML | 1 |
| Nabeka, H | 1 |
| Uematsu, K | 1 |
| Takechi, H | 1 |
| Shimokawa, T | 1 |
| Yamamiya, K | 1 |
| Li, C | 1 |
| Doihara, T | 1 |
| Saito, S | 1 |
| Kobayashi, N | 1 |
| Matsuda, S | 1 |
| Dahlberg, D | 1 |
| Mariussen, E | 1 |
| Goverud, IL | 1 |
| Tønjum, T | 1 |
| Mæhlen, J | 1 |
| Antal, EA | 1 |
| Hassel, B | 1 |
| García-Lara, L | 1 |
| Pérez-Severiano, F | 1 |
| González-Esquivel, D | 1 |
| Elizondo, G | 1 |
| Segovia, J | 1 |
| Shakya, AK | 1 |
| Kamal, M | 1 |
| Balaramnavar, VM | 1 |
| Bardaweel, SK | 1 |
| Naik, RR | 1 |
| Saxena, AK | 1 |
| Siddiqui, HH | 1 |
| Bist, R | 1 |
| Bhatt, DK | 1 |
| Gong, P | 1 |
| Basu, N | 1 |
| Scheuhammer, AM | 1 |
| Perkins, EJ | 1 |
| Eleuteri, S | 1 |
| Monti, B | 1 |
| Brignani, S | 1 |
| Contestabile, A | 1 |
| Onuigbo, MA | 1 |
| Nye, D | 1 |
| Iloanya, PC | 1 |
| Wood, DM | 1 |
| Berry, DJ | 1 |
| Glover, G | 1 |
| Eastwood, J | 1 |
| Dargan, PI | 1 |
| Saif, MW | 1 |
| Syrigos, K | 1 |
| Kaley, K | 1 |
| Isufi, I | 1 |
| de Tommaso, M | 1 |
| Lavolpe, V | 1 |
| Di Venere, D | 1 |
| Corsalini, M | 1 |
| Vecchio, E | 1 |
| Favia, G | 1 |
| Sardaro, M | 1 |
| Livrea, P | 1 |
| Nolano, M | 1 |
| Marmolino, D | 1 |
| Manto, M | 1 |
| El-Ansary, AK | 1 |
| Al-Daihan, SK | 1 |
| El-Gezeery, AR | 1 |
| Albrecht, J | 1 |
| Sidoryk-Węgrzynowicz, M | 2 |
| Zielińska, M | 1 |
| Aschner, M | 2 |
| Zacny, JP | 1 |
| Paice, JA | 1 |
| Coalson, DW | 1 |
| Dahmani, S | 1 |
| Tourrel, F | 1 |
| Blanc, T | 1 |
| Jegou-Colleter, S | 1 |
| Laudenbach, V | 1 |
| Katsenos, S | 1 |
| Psara, A | 1 |
| Panagou, C | 1 |
| Santos, D | 1 |
| Batoreu, MC | 1 |
| Almeida, I | 1 |
| Ramos, R | 1 |
| Marreilha dos Santos, AP | 1 |
| Sayed, RH | 1 |
| Salem, HA | 1 |
| El-Sayeh, BM | 1 |
| Lee, S | 1 |
| Cuadrado, A | 1 |
| Amat, G | 1 |
| Armijo, JA | 1 |
| Santamaría, A | 1 |
| Salvatierra-Sánchez, R | 1 |
| Vázquez-Román, B | 1 |
| Santiago-López, D | 1 |
| Villeda-Hernández, J | 1 |
| Galván-Arzate, S | 1 |
| Jiménez-Capdeville, ME | 1 |
| Ali, SF | 1 |
| Pancetti, F | 1 |
| Oyarce, M | 1 |
| Aranda, M | 1 |
| Parodi, J | 1 |
| Aguayo, LG | 1 |
| Morales, B | 1 |
| Westphal, G | 1 |
| Müller, M | 1 |
| Hallier, E | 1 |
| Zeise, ML | 1 |
| Carlson, KM | 1 |
| Wagner, GC | 1 |
| Gascon, E | 1 |
| Klauser, P | 1 |
| Kiss, JZ | 1 |
| Vutskits, L | 1 |
| Kang, TC | 1 |
| Kang, JH | 1 |
| Kim, HT | 1 |
| Lee, SJ | 1 |
| Choi, UK | 1 |
| Kim, JE | 1 |
| Kwak, SE | 1 |
| Kim, DW | 1 |
| Choi, SY | 1 |
| Kwon, OS | 1 |
| Casey, DE | 1 |
| Alao, AO | 1 |
| Dewan, MJ | 1 |
| Wong, IC | 1 |
| Mawer, GE | 1 |
| Sander, JW | 1 |
6 reviews available for gamma-aminobutyric acid and Encephalopathy, Toxic
| Article | Year |
|---|---|
Early Development of the GABAergic System and the Associated Risks of Neonatal Anesthesia.
Topics: Anesthesia, General; Animals; Animals, Newborn; Apoptosis; Brain; Child Behavior Disorders; Child, P | 2021 |
Asterixis related to gabapentin intake: a case report and review.
Topics: Aged; Amines; Cyclohexanecarboxylic Acids; Dyskinesias; Gabapentin; gamma-Aminobutyric Acid; Humans; | 2013 |
Roles of glutamine in neurotransmission.
Topics: Animals; Central Nervous System; Epilepsy; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans | 2010 |
[Neurological consequences after long-term sedation in the ICU].
Topics: Aging; Anesthetics, General; Animals; Cesarean Section; Conscious Sedation; Critical Care; Excitator | 2012 |
Potentially toxic effects of anaesthetics on the developing central nervous system.
Topics: Anesthetics; Animals; Animals, Newborn; Brain; Central Nervous System; gamma-Aminobutyric Acid; Glut | 2007 |
Tardive dyskinesia: pathophysiology and animal models.
Topics: Age Factors; Animals; Antipsychotic Agents; Basal Ganglia; Behavior, Animal; Disease Models, Animal; | 2000 |
1 trial available for gamma-aminobutyric acid and Encephalopathy, Toxic
| Article | Year |
|---|---|
Subjective, psychomotor, and physiological effects of pregabalin alone and in combination with oxycodone in healthy volunteers.
Topics: Adult; Analgesics; Analgesics, Opioid; Anticonvulsants; Cross-Over Studies; Dose-Response Relationsh | 2012 |
31 other studies available for gamma-aminobutyric acid and Encephalopathy, Toxic
| Article | Year |
|---|---|
Carboxyl-modified polystyrene microplastics induces neurotoxicity by affecting dopamine, glutamate, serotonin, and GABA neurotransmission in Caenorhabditis elegans.
Topics: Animals; Caenorhabditis elegans; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Microplastics; Ne | 2023 |
Carboxyl-modified polystyrene microplastics induces neurotoxicity by affecting dopamine, glutamate, serotonin, and GABA neurotransmission in Caenorhabditis elegans.
Topics: Animals; Caenorhabditis elegans; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Microplastics; Ne | 2023 |
Carboxyl-modified polystyrene microplastics induces neurotoxicity by affecting dopamine, glutamate, serotonin, and GABA neurotransmission in Caenorhabditis elegans.
Topics: Animals; Caenorhabditis elegans; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Microplastics; Ne | 2023 |
Carboxyl-modified polystyrene microplastics induces neurotoxicity by affecting dopamine, glutamate, serotonin, and GABA neurotransmission in Caenorhabditis elegans.
Topics: Animals; Caenorhabditis elegans; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Microplastics; Ne | 2023 |
Nano selenium ameliorates oxidative stress and inflammatory response associated with cypermethrin-induced neurotoxicity in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Brain; Cytokines; gamma-Aminobutyric Acid; Glutathi | 2020 |
Magnesium Sulfate Prevents Neurochemical and Long-Term Behavioral Consequences of Neonatal Excitotoxic Lesions: Comparison Between Male and Female Mice.
Topics: Aging; Animals; Animals, Newborn; Brain; Calcium Channel Blockers; Disease Models, Animal; Excitator | 2017 |
Dose-dependent neuroprotective effect of oriental phyto-derived glycyrrhizin on experimental neuroterminal norepinephrine depletion in a rat brain model.
Topics: Acetylcholinesterase; Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cerebral Cortex; | 2019 |
Protective effect of arctigenin against MPP+ and MPTP-induced neurotoxicity.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; bcl-2-Associated X Protein; Behavior, Animal; Brain | 2014 |
Synthesis and anticonvulsant activity evaluation of 7-alkoxy[1,2,4]triazolo[3,4-b]benzothiazol-3(2H)-ones.
Topics: Administration, Oral; Animals; Anticonvulsants; Disease Models, Animal; Electroshock; gamma-Aminobut | 2014 |
Gabapentin-induced encephalopathy.
Topics: Aged, 80 and over; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Electroencephalography; Fem | 2015 |
Prosaposin overexpression following kainic acid-induced neurotoxicity.
Topics: Animals; Cerebral Cortex; Choroid Plexus; GABAergic Neurons; gamma-Aminobutyric Acid; Gene Expressio | 2014 |
Staphylococcal α-hemolysin is neurotoxic and causes lysis of brain cells in vivo and in vitro.
Topics: Animals; Astrocytes; Bacterial Toxins; Brain; Brain Edema; Cell Death; Cells, Cultured; gamma-Aminob | 2015 |
Absence of aryl hydrocarbon receptors increases endogenous kynurenic acid levels and protects mouse brain against excitotoxic insult and oxidative stress.
Topics: Acetyltransferases; Animals; Basic Helix-Loop-Helix Transcription Factors; Brain; Disease Models, An | 2015 |
Design, synthesis and evaluation of benzofuran-acetamide scaffold as potential anticonvulsant agent.
Topics: 4-Aminobutyrate Transaminase; Acetamides; Animals; Anticonvulsants; Benzofurans; Binding Sites; Cere | 2016 |
The evaluation of effect of alpha-lipoic acid and vitamin E on the lipid peroxidation, gamma-amino butyric acid and serotonin level in the brain of mice (Mus musculus) acutely intoxicated with lindane.
Topics: Animals; Brain; Disease Models, Animal; gamma-Aminobutyric Acid; Hexachlorocyclohexane; Insecticides | 2009 |
Neurochemical and electrophysiological diagnosis of reversible neurotoxicity in earthworms exposed to sublethal concentrations of CL-20.
Topics: Animals; Aza Compounds; Biogenic Monoamines; Dose-Response Relationship, Drug; Electrophysiology; En | 2010 |
Chronic dietary administration of valproic acid protects neurons of the rat nucleus basalis magnocellularis from ibotenic acid neurotoxicity.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Basal Nucleus of Meynert; Cerebral Cortex; Choline O-A | 2009 |
Drug-induced encephalopathy secondary to non renal dosing of common medications in Two dialysis patients.
Topics: Acyclovir; Aged; Amines; Analgesics; Antiviral Agents; Cyclohexanecarboxylic Acids; Gabapentin; gamm | 2009 |
Significant pregabalin toxicity managed with supportive care alone.
Topics: Analgesics; Drug Overdose; gamma-Aminobutyric Acid; Humans; Intubation, Intratracheal; Male; Middle | 2010 |
Role of pregabalin in treatment of oxaliplatin-induced sensory neuropathy.
Topics: Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Deoxycyti | 2010 |
A case of unilateral burning mouth syndrome of neuropathic origin.
Topics: Aged; Analgesics; Anesthesia, Dental; Biopsy; Burning Mouth Syndrome; gamma-Aminobutyric Acid; Human | 2011 |
Pregabalin antagonizes copper-induced toxicity in the brain: in vitro and in vivo studies.
Topics: Animals; Cell Line, Tumor; Cell Survival; Copper; gamma-Aminobutyric Acid; Humans; Motor Cortex; Neu | 2010 |
On the protective effect of omega-3 against propionic acid-induced neurotoxicity in rat pups.
Topics: Animals; Brain; Caspase 3; Dopamine; Fatty Acids, Omega-3; gamma-Aminobutyric Acid; Humans; Interleu | 2011 |
Pemetrexed-induced cellulitis: a rare toxicity in non-small cell lung cancer treatment.
Topics: Adrenal Cortex Hormones; Aged; Amines; Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Ca | 2013 |
Manganese alters rat brain amino acids levels.
Topics: Amino Acids; Animals; Brain; Brain Chemistry; Chlorides; Dose-Response Relationship, Drug; Extrapyra | 2012 |
Potential protective effect of taurine against dibromoacetonitrile-induced neurotoxicity in rats.
Topics: Acetonitriles; Animals; Antioxidants; Aspartate Aminotransferases; Disinfectants; Dose-Response Rela | 2012 |
Pregabalin intoxication-induced encephalopathy with triphasic waves.
Topics: Aged; Anticonvulsants; Brain; Electroencephalography; Female; gamma-Aminobutyric Acid; Humans; Neuro | 2012 |
Is the interaction between felbamate and valproate against seizures induced by 4-aminopyridine and pentylenetetrazole in mice beneficial?
Topics: 4-Aminopyridine; Analysis of Variance; Animals; Brain; Chromatography, Liquid; Disease Models, Anima | 2003 |
Protective effects of the antioxidant selenium on quinolinic acid-induced neurotoxicity in rats: in vitro and in vivo studies.
Topics: Animals; Antioxidants; Behavior, Animal; Body Weight; Brain Chemistry; Corpus Striatum; gamma-Aminob | 2003 |
S-methylcysteine may be a causal factor in monohalomethane neurotoxicity.
Topics: Animals; Cells, Cultured; Cysteine; Electric Stimulation; Electrophysiology; gamma-Aminobutyric Acid | 2004 |
Effects of phencyclidine on schedule-controlled responding following neurotoxic lesions of the striatum.
Topics: Animals; Conditioning, Operant; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Rel | 2005 |
Anticonvulsant characteristics of pyridoxyl-gamma-aminobutyrate, PL-GABA.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bicuculline; Drug Tolerance; Electrophysiology; | 2008 |
Evaluating the tolerability of the newer mood stabilizers.
Topics: Acetates; Amines; Anticonvulsants; Bipolar Disorder; Central Nervous System Diseases; Cyclohexanecar | 2001 |
Adverse event monitoring in lamotrigine patients: a pharmacoepidemiologic study in the United Kingdom.
Topics: Acetates; Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Amines; Anticonvulsants; | 2001 |