gamma-aminobutyric acid has been researched along with Drug Overdose in 37 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pyridoxine-dependent seizures have been recognised for 40 years, but the clinical and biochemical features are still not understood." | 8.82 | Pyridoxine-dependent seizures: a clinical and biochemical conundrum. ( Baxter, P, 2003) |
| "The goal of this study was to establish and compare baseline data on the prevalence of gabapentin identified through postmortem toxicology testing among drug overdose decedents in several geographically diverse states/jurisdictions with differing levels of drug overdose fatality burdens in 2015." | 7.88 | Prevalence of gabapentin in drug overdose postmortem toxicology testing results. ( Bunn, TL; Christy, D; Kirschke, D; Light, T; Miller, A; Slavova, S; Thompson, G; White, JR; Winecker, R, 2018) |
| " jurisdictions were used to identify residents who died from drug overdoses in year 2015 and to calculate prevalence rates of gabapentin in postmortem toxicology by jurisdiction." | 7.88 | Prevalence of gabapentin in drug overdose postmortem toxicology testing results. ( Bunn, TL; Christy, D; Kirschke, D; Light, T; Miller, A; Slavova, S; Thompson, G; White, JR; Winecker, R, 2018) |
| "On average, 22% of all drug overdose decedents in our study tested positive for gabapentin." | 7.88 | Prevalence of gabapentin in drug overdose postmortem toxicology testing results. ( Bunn, TL; Christy, D; Kirschke, D; Light, T; Miller, A; Slavova, S; Thompson, G; White, JR; Winecker, R, 2018) |
| "Pyridoxine-dependent seizures have been recognised for 40 years, but the clinical and biochemical features are still not understood." | 6.42 | Pyridoxine-dependent seizures: a clinical and biochemical conundrum. ( Baxter, P, 2003) |
| "Gabapentinoids were involved in 2115 (2." | 5.48 | Intentional Drug Overdose Involving Pregabalin and Gabapentin: Findings from the National Self-Harm Registry Ireland, 2007-2015. ( Arensman, E; Ashcroft, DM; Daly, C; Griffin, E; Perry, IJ; Webb, RT, 2018) |
| "gov, and US FDA data, indexed through 28 July 2016, utilizing the following searches: pregabalin OR gabapentin OR gabapentinoid AND one of the following: abuse, misuse, overdose, or substance-related disorders[MESH], was conducted." | 4.95 | Abuse and Misuse of Pregabalin and Gabapentin. ( Evoy, KE; Morrison, MD; Saklad, SR, 2017) |
| "Clinically significant side effects of the new anticonvulsants, such as metabolic acidosis from topiramate, autoimmune reactions from lamotrigine, hyponatremia from oxcarbazepine, or psychosis from levitiracetam can cause serious morbidity and mortality if unrecognized." | 4.86 | Emergent complications of the newer anticonvulsants. ( Dang, CV; Nelson, L; Wade, JF; Wasserberger, J, 2010) |
| "Pyridoxine-dependent seizures have been recognised for 40 years, but the clinical and biochemical features are still not understood." | 4.82 | Pyridoxine-dependent seizures: a clinical and biochemical conundrum. ( Baxter, P, 2003) |
| "The goal of this study was to establish and compare baseline data on the prevalence of gabapentin identified through postmortem toxicology testing among drug overdose decedents in several geographically diverse states/jurisdictions with differing levels of drug overdose fatality burdens in 2015." | 3.88 | Prevalence of gabapentin in drug overdose postmortem toxicology testing results. ( Bunn, TL; Christy, D; Kirschke, D; Light, T; Miller, A; Slavova, S; Thompson, G; White, JR; Winecker, R, 2018) |
| " jurisdictions were used to identify residents who died from drug overdoses in year 2015 and to calculate prevalence rates of gabapentin in postmortem toxicology by jurisdiction." | 3.88 | Prevalence of gabapentin in drug overdose postmortem toxicology testing results. ( Bunn, TL; Christy, D; Kirschke, D; Light, T; Miller, A; Slavova, S; Thompson, G; White, JR; Winecker, R, 2018) |
| "On average, 22% of all drug overdose decedents in our study tested positive for gabapentin." | 3.88 | Prevalence of gabapentin in drug overdose postmortem toxicology testing results. ( Bunn, TL; Christy, D; Kirschke, D; Light, T; Miller, A; Slavova, S; Thompson, G; White, JR; Winecker, R, 2018) |
| "There are two previously reported cases describing the management of pregabalin self-poisoning and one further case of management of therapeutic pregabalin accumulation." | 3.76 | Significant pregabalin toxicity managed with supportive care alone. ( Berry, DJ; Dargan, PI; Eastwood, J; Glover, G; Wood, DM, 2010) |
| "Gabapentin is an anticonvulsant that is being used for an increasing number of off-label indications." | 2.71 | Characterization of gabapentin overdose using a poison center case series. ( Dahl, B; Gorman, S; Klein-Schwartz, W; Shepherd, JG, 2003) |
| "Risk factors include a history of substance abuse, particularly opioids, and psychiatric co-morbidities." | 2.55 | Abuse and Misuse of Pregabalin and Gabapentin. ( Evoy, KE; Morrison, MD; Saklad, SR, 2017) |
| "Pyridoxine-dependent seizures have been recognised for 40 years, but the clinical and biochemical features are still not understood." | 2.42 | Pyridoxine-dependent seizures: a clinical and biochemical conundrum. ( Baxter, P, 2003) |
| "Epilepsy affects 1." | 2.41 | New antiepileptic drugs and preparations. ( Jagoda, A; Yoon, Y, 2000) |
| "Anxiety and chronic pain are common comorbidities in patients with chronic obstructive pulmonary disease (COPD), which are frequently managed with benzodiazepines (BZDs) and opioids, respectively." | 1.91 | Co-prescribing of Central Nervous System-Active Medications for COPD Patients: Impact on Emergency Room Visits and Hospitalization. ( Kuo, YF; Raji, MA; Sharma, G; Sood, A; Westra, J, 2023) |
| "Flunitrazepam is a newer benzodiazepine that is preferentially used recreationally and to facilitate sexual assault." | 1.62 | Sedative-Hypnotic Agents That Impact Gamma-Aminobutyric Acid Receptors: Focus on Flunitrazepam, Gamma-Hydroxybutyric Acid, Phenibut, and Selank. ( Doyno, CR; White, CM, 2021) |
| "Flunitrazepam has greater potency and higher affinity for the type A GABA receptor than most benzodiazepines." | 1.62 | Sedative-Hypnotic Agents That Impact Gamma-Aminobutyric Acid Receptors: Focus on Flunitrazepam, Gamma-Hydroxybutyric Acid, Phenibut, and Selank. ( Doyno, CR; White, CM, 2021) |
| " Chronic use of these GABAergic drugs can lead to significant withdrawal syndromes." | 1.62 | Sedative-Hypnotic Agents That Impact Gamma-Aminobutyric Acid Receptors: Focus on Flunitrazepam, Gamma-Hydroxybutyric Acid, Phenibut, and Selank. ( Doyno, CR; White, CM, 2021) |
| "Gabapentinoids were involved in 2115 (2." | 1.48 | Intentional Drug Overdose Involving Pregabalin and Gabapentin: Findings from the National Self-Harm Registry Ireland, 2007-2015. ( Arensman, E; Ashcroft, DM; Daly, C; Griffin, E; Perry, IJ; Webb, RT, 2018) |
| " In the dose-response analysis, moderate-dose (OR 2." | 1.46 | Gabapentin, opioids, and the risk of opioid-related death: A population-based nested case-control study. ( Antoniou, T; Gomes, T; Juurlink, DN; Mamdani, MM; Paterson, JM; van den Brink, W, 2017) |
| "Gabapentin is an antiepileptic drug that is prescribed for both FDA-approved and multiple off-label conditions, and has a relatively safe side-effect profile." | 1.37 | Suicide by gabapentin overdose. ( Middleton, O, 2011) |
| "The patient presented with seizures and a reduced level of consciousness." | 1.34 | Self-poisoning with lamotrigine and pregabalin. ( Braga, AJ; Chidley, K, 2007) |
| "Quetiapine overdose is associated with coma, QTc prolongation and hypotension." | 1.31 | Massive gabapentin and presumptive quetiapine overdose. ( Cutino, L; Dunaway, MD; Spiller, HA, 2002) |
| "Gabapentin is an antiepileptic agent that is indicated for use as adjunctive therapy for partial seizures." | 1.30 | A case of sustained massive gabapentin overdose without serious side effects. ( Radtke, RA; St Clair, EW; Verma, A, 1999) |
| " It has a relatively benign side effect profile, but little data exists on massive overdoses with this agent." | 1.30 | A case of sustained massive gabapentin overdose without serious side effects. ( Radtke, RA; St Clair, EW; Verma, A, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (18.92) | 18.2507 |
| 2000's | 11 (29.73) | 29.6817 |
| 2010's | 16 (43.24) | 24.3611 |
| 2020's | 3 (8.11) | 2.80 |
| Authors | Studies |
|---|---|
| Kuo, YF | 2 |
| Liaw, V | 1 |
| Yu, X | 1 |
| Raji, MA | 2 |
| Sood, A | 1 |
| Westra, J | 1 |
| Sharma, G | 1 |
| Doyno, CR | 1 |
| White, CM | 1 |
| Lyndon, A | 1 |
| Audrey, S | 1 |
| Wells, C | 1 |
| Burnell, ES | 1 |
| Ingle, S | 1 |
| Hill, R | 1 |
| Hickman, M | 1 |
| Henderson, G | 1 |
| Gomes, T | 1 |
| Juurlink, DN | 1 |
| Antoniou, T | 1 |
| Mamdani, MM | 1 |
| Paterson, JM | 1 |
| van den Brink, W | 1 |
| Bonnet, U | 1 |
| Scherbaum, N | 1 |
| Daly, C | 1 |
| Griffin, E | 1 |
| Ashcroft, DM | 1 |
| Webb, RT | 1 |
| Perry, IJ | 1 |
| Arensman, E | 1 |
| Slavova, S | 1 |
| Miller, A | 1 |
| Bunn, TL | 1 |
| White, JR | 1 |
| Kirschke, D | 1 |
| Light, T | 1 |
| Christy, D | 1 |
| Thompson, G | 1 |
| Winecker, R | 1 |
| McCabe, DJ | 1 |
| Bangh, SA | 1 |
| Arens, AM | 1 |
| Cole, JB | 1 |
| Schauer, SG | 1 |
| Varney, SM | 1 |
| Sullivan, RW | 1 |
| Ryzewski, M | 1 |
| Holland, MG | 1 |
| Marraffa, JM | 1 |
| Spence, D | 1 |
| Priez-Barallon, C | 1 |
| Carlier, J | 1 |
| Boyer, B | 1 |
| Benslima, M | 1 |
| Fanton, L | 1 |
| Mazoyer, C | 1 |
| Gaillard, Y | 1 |
| Sankary, S | 1 |
| Canino, P | 1 |
| Jackson, J | 1 |
| Evoy, KE | 1 |
| Morrison, MD | 1 |
| Saklad, SR | 1 |
| Spiller, HA | 2 |
| Bratcher, R | 1 |
| Griffith, JR | 1 |
| Wade, JF | 1 |
| Dang, CV | 1 |
| Nelson, L | 1 |
| Wasserberger, J | 1 |
| Kalaci, A | 1 |
| Duru, M | 1 |
| Karazincir, S | 1 |
| Sevinç, TT | 1 |
| Kuvandik, G | 1 |
| Balci, A | 1 |
| Wood, DM | 1 |
| Berry, DJ | 1 |
| Glover, G | 1 |
| Eastwood, J | 1 |
| Dargan, PI | 1 |
| Middleton, O | 1 |
| Imhof, K | 1 |
| Krall, K | 1 |
| Gombotz, H | 1 |
| Dunaway, MD | 1 |
| Cutino, L | 1 |
| Klein-Schwartz, W | 1 |
| Shepherd, JG | 1 |
| Gorman, S | 1 |
| Dahl, B | 1 |
| Baxter, P | 1 |
| Carai, MA | 1 |
| Colombo, G | 1 |
| Gessa, GL | 1 |
| Meyer, S | 1 |
| Kleinschmidt, S | 1 |
| Gottschling, S | 1 |
| Gortner, L | 1 |
| Strittmatter, M | 1 |
| Rasimas, JJ | 1 |
| Burkhart, KK | 1 |
| Braga, AJ | 1 |
| Chidley, K | 1 |
| Fischer, JH | 1 |
| Barr, AN | 1 |
| Rogers, SL | 1 |
| Fischer, PA | 1 |
| Trudeau, VL | 1 |
| Fernández, MC | 1 |
| Walter, FG | 1 |
| Petersen, LR | 1 |
| Walkotte, SM | 1 |
| Davie, MB | 1 |
| Cook, MJ | 1 |
| Ng, C | 1 |
| Stevenson, CM | 1 |
| Kim, J | 1 |
| Fleisher, D | 1 |
| Stopforth, J | 1 |
| Verma, A | 1 |
| St Clair, EW | 1 |
| Radtke, RA | 1 |
| Yoon, Y | 1 |
| Jagoda, A | 1 |
| Jones, H | 1 |
| Aguila, E | 1 |
| Farber, HW | 1 |
| Sherif, F | 1 |
| Marcusson, J | 1 |
| Oreland, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
| Intervention | Intensity score (Mean) |
|---|---|
| Topical KeAmLi Combo | 62.7 |
| Topical Ketamine | 63.1 |
| Topical Amitriptyline | 69.2 |
| Topical Lidocaine | 65.8 |
| Topical Vehicle | 61.9 |
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
| Intervention | mN (Mean) | |
|---|---|---|
| Mechanical Detection Threshold | Mechanical Pain Threshold | |
| Topical Amitriptyline | 3.573423965 | 152.4768146 |
| Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
| Topical Ketamine | 3.464204768 | 135.9 |
| Topical Lidocaine | 3.546037659 | 126.9 |
| Topical Vehicle | 3.525692637 | 148.7138273 |
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
| Intervention | Degrees celsius (Mean) | |
|---|---|---|
| Warm Detection Threshold | Heat Pain Threshold | |
| Topical Amitriptyline | 33.9 | 40.0 |
| Topical KeAmLi Combo | 33.6 | 39.8 |
| Topical Ketamine | 34.0 | 40.0 |
| Topical Lidocaine | 33.7 | 39.4 |
| Topical Vehicle | 33.8 | 39.7 |
6 reviews available for gamma-aminobutyric acid and Drug Overdose
| Article | Year |
|---|---|
How addictive are gabapentin and pregabalin? A systematic review.
Topics: Amines; Analgesics; Behavior, Addictive; Cyclohexanecarboxylic Acids; Databases, Bibliographic; Drug | 2017 |
Abuse and Misuse of Pregabalin and Gabapentin.
Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Drug Overdose; Gabapentin; gamma-Aminobutyric Acid; | 2017 |
Emergent complications of the newer anticonvulsants.
Topics: Acidosis; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Overdose; Fructo | 2010 |
Pyridoxine-dependent seizures: a clinical and biochemical conundrum.
Topics: Drug Overdose; gamma-Aminobutyric Acid; Humans; Pyridoxal Phosphate; Pyridoxine; Seizures | 2003 |
[Gamma-hydroxy butyric acid: neurotransmitter, sedative and party drug].
Topics: Adult; Animals; Brain; Child; Critical Care; Drug Overdose; gamma-Aminobutyric Acid; Humans; Hydroxy | 2005 |
New antiepileptic drugs and preparations.
Topics: Acetates; Administration, Rectal; Age Factors; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; | 2000 |
1 trial available for gamma-aminobutyric acid and Drug Overdose
| Article | Year |
|---|---|
Characterization of gabapentin overdose using a poison center case series.
Topics: Acetates; Adolescent; Adult; Aged; Aged, 80 and over; Amines; Anticonvulsants; Child; Child, Prescho | 2003 |
30 other studies available for gamma-aminobutyric acid and Drug Overdose
| Article | Year |
|---|---|
Opioid and Benzodiazepine Substitutes: Impact on Drug Overdose Mortality in Medicare Population.
Topics: Aged; Analgesics, Opioid; Benzodiazepines; Case-Control Studies; Drug Overdose; gamma-Aminobutyric A | 2022 |
Co-prescribing of Central Nervous System-Active Medications for COPD Patients: Impact on Emergency Room Visits and Hospitalization.
Topics: Aged; Analgesics, Opioid; Central Nervous System; Chronic Pain; Drug Overdose; Emergency Service, Ho | 2023 |
Sedative-Hypnotic Agents That Impact Gamma-Aminobutyric Acid Receptors: Focus on Flunitrazepam, Gamma-Hydroxybutyric Acid, Phenibut, and Selank.
Topics: Drug Overdose; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Hypnotics and Sedatives; Oligopeptide | 2021 |
Risk to heroin users of polydrug use of pregabalin or gabapentin.
Topics: Adult; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Drug Intera | 2017 |
Gabapentin, opioids, and the risk of opioid-related death: A population-based nested case-control study.
Topics: Adult; Aged; Amines; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studi | 2017 |
Intentional Drug Overdose Involving Pregabalin and Gabapentin: Findings from the National Self-Harm Registry Ireland, 2007-2015.
Topics: Adult; Alcohol Drinking; Amines; Cyclohexanecarboxylic Acids; Drug Overdose; Emergency Service, Hosp | 2018 |
Prevalence of gabapentin in drug overdose postmortem toxicology testing results.
Topics: Adult; Amines; Analgesics, Opioid; Cyclohexanecarboxylic Acids; Drug Overdose; Excitatory Amino Acid | 2018 |
Phenibut exposures and clinical effects reported to a regional poison center.
Topics: Adult; Aged; Aged, 80 and over; Central Nervous System Depressants; Drug Overdose; Female; gamma-Ami | 2019 |
Gabapentin overdose in a military beneficiary.
Topics: Amines; Anti-Anxiety Agents; Cyclohexanecarboxylic Acids; Drug Overdose; Electrocardiography; Female | 2013 |
Compounded ointment results in severe toxicity in a pediatric patient.
Topics: Administration, Cutaneous; Amines; Analgesics; Body Surface Area; Bradycardia; Clonidine; Combined M | 2013 |
Bad medicine: gabapentin and pregabalin.
Topics: Amines; Analgesics; Anti-Anxiety Agents; Cyclohexanecarboxylic Acids; Drug Overdose; Female; Gabapen | 2013 |
Quantification of pregabalin using hydrophilic interaction HPLC-high-resolution MS in postmortem human samples: eighteen case reports.
Topics: Adult; Aged; Aged, 80 and over; Autopsy; Chromatography, High Pressure Liquid; Drug Overdose; Female | 2014 |
Phenibut overdose.
Topics: Adult; Confusion; Direct-to-Consumer Advertising; Drug Overdose; GABA Agonists; gamma-Aminobutyric A | 2017 |
Pregabalin overdose with benign outcome.
Topics: Anticonvulsants; Antidotes; Charcoal; Drug Overdose; Female; gamma-Aminobutyric Acid; Humans; Middle | 2008 |
Thoracic spine compression fracture during isoniazid-induced seizures: case report.
Topics: Antidotes; Back Pain; Charcoal; Child; Drug Overdose; Epilepsy, Tonic-Clonic; Female; Fractures, Com | 2008 |
Significant pregabalin toxicity managed with supportive care alone.
Topics: Analgesics; Drug Overdose; gamma-Aminobutyric Acid; Humans; Intubation, Intratracheal; Male; Middle | 2010 |
Suicide by gabapentin overdose.
Topics: Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Depressive Disorder, Major; Drug Overdose; Fem | 2011 |
[Life-threatening opioid overdose. Decoding the physician pin code of a patient-controlled anesthesia pump by patients].
Topics: Adolescent; Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Codeine; Critical Care; Drug O | 2012 |
Massive gabapentin and presumptive quetiapine overdose.
Topics: Acetates; Amines; Anti-Anxiety Agents; Antipsychotic Agents; Coma; Cyclohexanecarboxylic Acids; Dibe | 2002 |
Resuscitative effect of a gamma-aminobutyric acid B receptor antagonist on gamma-hydroxybutyric acid mortality in mice.
Topics: Animals; Benzocycloheptenes; Bicuculline; Drug Overdose; Flumazenil; GABA Antagonists; gamma-Aminobu | 2005 |
Cardiac conduction disturbances after an overdose of nefazodone and gabapentin.
Topics: Adult; Amines; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Cyclohexanecarboxylic | 2006 |
Self-poisoning with lamotrigine and pregabalin.
Topics: Adult; Anticonvulsants; Drug Overdose; gamma-Aminobutyric Acid; Humans; Lamotrigine; Male; Pregabali | 2007 |
Lack of serious toxicity following gabapentin overdose.
Topics: Acetates; Adolescent; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Drug Overdose; Female; G | 1994 |
Gabapentin, valproic acid, and ethanol intoxication: elevated blood levels with mild clinical effects.
Topics: Acetates; Adult; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Drug Interactions; Drug Overd | 1996 |
Vigabatrin overdose.
Topics: Adult; Anticonvulsants; Combined Modality Therapy; Drug Overdose; Epilepsy, Temporal Lobe; Female; g | 1996 |
Colonic absorption of antiepileptic agents.
Topics: Acetates; Amines; Animals; Anticonvulsants; Biological Transport; Chromatography, High Pressure Liqu | 1997 |
Overdose with gabapentin and lamotrigine.
Topics: Acetates; Adolescent; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Drug Overdose; Female; G | 1997 |
A case of sustained massive gabapentin overdose without serious side effects.
Topics: Acetates; Adult; Amines; Anticonvulsants; Cognition; Cyclohexanecarboxylic Acids; Drug Overdose; Epi | 1999 |
Gabapentin toxicity requiring intubation in a patient receiving long-term hemodialysis.
Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Drug Overdose; Female; Gabapentin; g | 2002 |
Brain gamma-aminobutyrate transaminase and monoamine oxidase activities in suicide victims.
Topics: 4-Aminobutyrate Transaminase; Adolescent; Adult; Age Factors; Aged; Anxiety Disorders; Brain; Brain | 1991 |