gamma-aminobutyric acid has been researched along with Disorder, Borderline Personality in 5 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The anticonvulsants valproate and topiramate appeared to have the most empirical support for having a favorable effect on symptoms of borderline personality disorder." | 4.85 | [Empirical evidence for the use of anticonvulsants in personality disorders]. ( Emrich, HM; Sieberer, M, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gradinger, T | 1 |
| Sack, M | 3 |
| Cardinale, V | 1 |
| Thiacourt, M | 1 |
| Baumgärtner, U | 1 |
| Schmahl, C | 3 |
| Ende, G | 3 |
| Cackowski, S | 2 |
| Van Eijk, J | 2 |
| Demirakca, T | 2 |
| Kleindienst, N | 1 |
| Bohus, M | 1 |
| Sobanski, E | 1 |
| Krause-Utz, A | 2 |
| Wang, GY | 1 |
| Sieberer, M | 1 |
| Emrich, HM | 1 |
| Gurvits, IG | 1 |
| Koenigsberg, HW | 1 |
| Siever, LJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Measuring Glutamate and GABA Brain Levels in Adults With Attention Deficit Hyperactivity Disorder (ADHD) Using Magnetic Resonance Spectroscopy (MRS)[NCT04823364] | 60 participants (Anticipated) | Interventional | 2022-10-01 | Not yet recruiting | |||
| Imaging Framework for Testing GABAergic/Glutamatergic Drugs in Bipolar Alcoholics[NCT03220776] | Phase 2 | 54 participants (Actual) | Interventional | 2017-08-07 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Concentrations of GABA+, referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy (i.e., MEGA-PRESS). (NCT03220776)
Timeframe: Day 5 of each experimental condition
| Intervention | mmol/kg (Mean) |
|---|---|
| N-Acetylcysteine | 3.90 |
| Gabapentin | 3.93 |
| Placebo Oral Tablet | 3.73 |
Concentrations of Glx (i.e., glutamate + glutamine), referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy. (NCT03220776)
Timeframe: Day 5 of each experimental condition
| Intervention | mmol/kg (Mean) |
|---|---|
| N-Acetylcysteine | 21.59 |
| Gabapentin | 21.69 |
| Placebo Oral Tablet | 22.25 |
2 reviews available for gamma-aminobutyric acid and Disorder, Borderline Personality
| Article | Year |
|---|---|
[Empirical evidence for the use of anticonvulsants in personality disorders].
Topics: Amines; Anticonvulsants; Borderline Personality Disorder; Carbamazepine; Cyclohexanecarboxylic Acids | 2009 |
Neurotransmitter dysfunction in patients with borderline personality disorder.
Topics: Acetylcholine; Affect; Aggression; Animals; Arginine Vasopressin; Borderline Personality Disorder; B | 2000 |
3 other studies available for gamma-aminobutyric acid and Disorder, Borderline Personality
| Article | Year |
|---|---|
The glutamate to γ-aminobutyric acid ratio in the posterior insula is associated with pain perception in healthy women but not in women with borderline personality disorder.
Topics: Adolescent; Adult; Borderline Personality Disorder; Brain Mapping; Female; gamma-Aminobutyric Acid; | 2019 |
Impulsivity and Aggression in Female BPD and ADHD Patients: Association with ACC Glutamate and GABA Concentrations.
Topics: Adult; Aggression; Attention Deficit Disorder with Hyperactivity; Borderline Personality Disorder; C | 2016 |
Impulsivity and Aggression in Female BPD and ADHD Patients: Association with ACC Glutamate and GABA Concentrations.
Topics: Adult; Aggression; Attention Deficit Disorder with Hyperactivity; Borderline Personality Disorder; C | 2016 |
Impulsivity and Aggression in Female BPD and ADHD Patients: Association with ACC Glutamate and GABA Concentrations.
Topics: Adult; Aggression; Attention Deficit Disorder with Hyperactivity; Borderline Personality Disorder; C | 2016 |
Impulsivity and Aggression in Female BPD and ADHD Patients: Association with ACC Glutamate and GABA Concentrations.
Topics: Adult; Aggression; Attention Deficit Disorder with Hyperactivity; Borderline Personality Disorder; C | 2016 |
ACC GABA levels are associated with functional activation and connectivity in the fronto-striatal network during interference inhibition in patients with borderline personality disorder.
Topics: Adolescent; Adult; Borderline Personality Disorder; Corpus Striatum; Female; Frontal Lobe; gamma-Ami | 2017 |