gamma-aminobutyric acid has been researched along with Disease Models, Animal in 1591 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this study, based on the excitatory/inhibitory imbalance theory of autism, the time window of GABA switch, the role of K-Cl co-transporter 2 (KCC2) in adjustment GABA switch, and brain permeability to erythropoietin (EPO), the effects of postnatal -EPO and- nano- erythropoietin (NEPO) have been evaluated in the valproic acid (VPA) rat model of autism." | 8.31 | The effects of postnatal erythropoietin and nano-erythropoietin on behavioral alterations by mediating K-Cl co-transporter 2 in the valproic acid-induced rat model of autism. ( Basiri, M; Darvishzadeh-Mahani, F; Haratizadeh, S; Nozari, M; Ranjbar, M, 2023) |
| "Although escitalopram is known to be an effective drug for adult depression, its disease-modifying efficacy on adolescents remains controversial." | 8.31 | Effects of Escitalopram on the Functional Neural Circuits in an Animal Model of Adolescent Depression. ( Choi, JY; Han, SJ; Kang, KJ; Lee, N; Nam, KR; Oh, SJ, 2023) |
| "The administration of escitalopram had no therapeutic effect on the adolescent depression." | 8.31 | Effects of Escitalopram on the Functional Neural Circuits in an Animal Model of Adolescent Depression. ( Choi, JY; Han, SJ; Kang, KJ; Lee, N; Nam, KR; Oh, SJ, 2023) |
| " Prolonged supplementation with both melatonin and SkQ1 (separately) suppressed the progression of the AMD-like pathology in OXYS rats without affecting the glutamate/GABA system but worsened the condition of the Wistar rat's retina during normal aging." | 8.12 | The glutamate/GABA system in the retina of male rats: effects of aging, neurodegeneration, and supplementation with melatonin and antioxidant SkQ1. ( Antonenko, AK; Fursova, AZ; Kolosova, NG; Telegina, DV, 2022) |
| "The goal of our study was to examine the long-term effect of vigabatrin (VGB), a γ-aminobutyric acid aminotransferase (GABA-AT) inhibitor on clonazepam (CLO), ethosuximide (ETX) and valproate (VPA) anticonvulsive activity against pentylenetetrazole (PTZ)-induced seizures in mice." | 7.96 | Long-term vigabatrin treatment modifies pentylenetetrazole-induced seizures in mice: focused on GABA brain concentration. ( Czuczwar, SJ; Krzyżanowski, M; Świąder, K; Świąder, MJ; Wróbel, A; Zakrocka, I; Łuszczki, JJ, 2020) |
| "In a 5-year follow-up study in a hospital in southern China, it was shown that intervertebral foramen (IVF) injection of ozone at the involved segmental levels could significantly alleviate paroxysmal spontaneous pain and mechanical allodynia in patients with chronic, intractable postherpetic neuralgia (PHN) and improve the quality of life." | 7.85 | Intervertebral Foramen Injection of Ozone Relieves Mechanical Allodynia and Enhances Analgesic Effect of Gabapentin in Animal Model of Neuropathic Pain. ( Chen, J; Guan, SM; Luo, WJ; Sun, W; Wang, JL; Wang, JS; Wang, XL; Wu, FF; Yang, F; Zheng, W, 2017) |
| "(1) IVF injection of ozone at L4-5 was only effective in suppression of mechanical allodynia in rats with neuropathic pain but not with inflammatory pain; (2) the analgesic effects of IVF ozone lasted much longer (> 14 days) than other selective molecular target drugs (< 48 hours) inhibiting or antagonizing at Nav1." | 7.85 | Intervertebral Foramen Injection of Ozone Relieves Mechanical Allodynia and Enhances Analgesic Effect of Gabapentin in Animal Model of Neuropathic Pain. ( Chen, J; Guan, SM; Luo, WJ; Sun, W; Wang, JL; Wang, JS; Wang, XL; Wu, FF; Yang, F; Zheng, W, 2017) |
| "Topical application of gabapentin gel ipsilaterally but not contralaterally alleviated CCI-induced static- (days 10-30) and dynamic-allodynia (days 15-30), suppressed cold-allodynia (days 10-30), heat- (days 15-30) and mechano-hyperalgesia (days 5-30) indicating a local action." | 7.85 | Topical gabapentin gel alleviates allodynia and hyperalgesia in the chronic sciatic nerve constriction injury neuropathic pain model. ( Ahmad, N; Akbar, S; Ali, G; Fawad, K; Sewell, RD; Shahid, M; Subhan, F, 2017) |
| "Carvacrol, a naturally occurring inhibitor of TRPM7 channels, is a novel, promising treatment to prevent early recurrence of SE, SE-related neuronal damage, and cognitive decline." | 7.85 | Carvacrol after status epilepticus (SE) prevents recurrent SE, early seizures, cell death, and cognitive decline. ( Khalil, A; Kovac, S; Morris, G; Walker, MC, 2017) |
| " Because the involvement of local inhibition in the dorsal horn, specifically that mediated by the inhibitory amino acids GABA and glycine, is so important in signal processing, we investigated regional inhibitory control of excitatory interneurons under control conditions and peripheral inflammation-induced mechanical allodynia." | 7.85 | Inhibition Mediated by Glycinergic and GABAergic Receptors on Excitatory Neurons in Mouse Superficial Dorsal Horn Is Location-Specific but Modified by Inflammation. ( Choudhury, P; Conway, CM; Flood, PD; MacDermott, AB; Mukai, J; Scherrer, G; Takazawa, T; Tong, CK, 2017) |
| "Consistent with the effects upon allodynia, both gabapentin and ketorolac produced a preference for the drug-paired compartment in the early phase of the K/BxN model, while gabapentin, but not ketorolac, resulted in a place preference during late phase." | 7.83 | The effect of gabapentin and ketorolac on allodynia and conditioned place preference in antibody-induced inflammation. ( Corr, M; McQueen, J; Park, HJ; Sandor, K; Svensson, CI; Woller, SA; Yaksh, TL, 2016) |
| "The important pathological consequences of insulin resistance arise from the detrimental effects of accumulated long-chain fatty acids and their respective acylcarnitines." | 7.83 | Decreased acylcarnitine content improves insulin sensitivity in experimental mice models of insulin resistance. ( Dambrova, M; Grinberga, S; Kuka, J; Liepinsh, E; Makarova, E; Makrecka-Kuka, M; Sevostjanovs, E; Svalbe, B; Volska, K, 2016) |
| "Monosodium glutamate (MSG), a flavor enhancer used in food, administered to neonatal rats causes neuronal lesions and leads to anxiety when adulthood." | 7.83 | Diphenyl diselenide ameliorates monosodium glutamate induced anxiety-like behavior in rats by modulating hippocampal BDNF-Akt pathway and uptake of GABA and serotonin neurotransmitters. ( Nogueira, CW; Quines, CB; Rosa, SG; Stangherlin, EC, 2016) |
| "The results confirm activity in chronic pain models predicted from affinity for the gabapentin site and suggests, at least partially, that α2δ-subunits of presynaptic voltage-gated calcium channels are involved in mediating this effect." | 7.83 | Optical isomers of phenibut inhibit [H(3)]-Gabapentin binding in vitro and show activity in animal models of chronic pain. ( Belozertseva, I; Danysz, W; Franke, L; Nagel, J; Valastro, B, 2016) |
| " Sulforaphane could be a new therapeutic approach to improve cognitive and motor function in hyperammonemia, hepatic encephalopathy, and other pathologies associated with neuroinflammation by promoting microglia differentiation from M1 to M2." | 7.83 | Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia. ( Agusti, A; Balzano, T; Cabrera-Pastor, A; Felipo, V; Gonzalez-Usano, A; Hernandez-Rabaza, V; Llansola, M; Taoro-Gonzalez, L, 2016) |
| "Experiments were designed to evaluate changes in the histamine release, mast cell number and neuronal damage in hippocampus induced by status epilepticus." | 7.81 | The mast cell stabilizer sodium cromoglycate reduces histamine release and status epilepticus-induced neuronal damage in the rat hippocampus. ( Orozco-Suárez, SA; Rocha, L; Santana-Gómez, CE; Valle-Dorado, MG, 2015) |
| "The serotonin system is intimately linked to both the mediation of anxiety and long-term effects of cocaine, potentially through interaction of inhibitory 5-HT2C receptor and gamma-aminobutyric acid (GABA) networks." | 7.81 | Dorsal raphe 5-HT(2C) receptor and GABA networks regulate anxiety produced by cocaine withdrawal. ( Craige, CP; Kirby, LG; Lewandowski, S; Unterwald, EM, 2015) |
| "The aim of the present study was to evaluate the effects of transcranial focal electrical stimulation (TFS) on γ-aminobutyric acid (GABA) and glutamate release in the hippocampus under basal conditions and during pilocarpine-induced status epilepticus (SE)." | 7.81 | Transcranial focal electrical stimulation reduces the convulsive expression and amino acid release in the hippocampus during pilocarpine-induced status epilepticus in rats. ( Alcántara-González, D; Bañuelos-Cabrera, I; Besio, W; Fernández-Mas, R; Luna-Munguía, H; Magdaleno-Madrigal, V; Rocha, L; Santana-Gómez, CE, 2015) |
| "We report that the oxytocin-mediated neuroprotective γ-aminobutyric acid (GABA) excitatory-inhibitory shift during delivery is abolished in the valproate and fragile X rodent models of autism." | 7.80 | Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring. ( Ben-Ari, Y; Brouchoud, C; Burnashev, N; Chazal, G; Eftekhari, S; Ferrari, DC; Khalilov, I; Lemonnier, E; Lozovaya, N; Nardou, R; Shahrokhi, A; Tsintsadze, T; Tsintsadze, V; Tyzio, R, 2014) |
| "Although pregabalin has been shown to have preclinical and clinical efficacy in neuropathic pain, the mechanism of its antinociceptive action is still unknown in other pain states." | 7.80 | Inhibition of mitogen-activated protein kinases phosphorylation plays an important role in the anti-nociceptive effect of pregabalin in zymosan-induced inflammatory pain model. ( Jeong, YC; Kwon, YB; Pyun, K, 2014) |
| "Piperine produced significant antianxiety-like activity in unstressed and stressed mice." | 7.80 | Possible involvement of GABAergic and nitriergic systems for antianxiety-like activity of piperine in unstressed and stressed mice. ( Dhingra, D; Gilhotra, N, 2014) |
| "These data indicate that MSCs were superior to gabapentin in ameliorating PTZ-induced epileptogenesis and verified the potential use of MSCs in seizure control, motor and cognitive impairments, oxidative stress, and the impairing GABA level in experimentally induced epilepsy." | 7.80 | Effects of intravenous human umbilical cord blood mesenchymal stem cell therapy versus gabapentin in pentylenetetrazole-induced chronic epilepsy in rats. ( Essawy, SS; Ewais, MM; Mohammed, AS; Tawfik, MK, 2014) |
| "Orofacial capsaicin and formalin tests were employed in male Wistar rats to assess the influence of pregabalin (or vehicle) pretreatment in acute pain models, and the results from these experiments were analyzed by one-way analysis of variance (ANOVA) followed by Newman Keuls post-hoc test." | 7.80 | Pregabalin reduces acute inflammatory and persistent pain associated with nerve injury and cancer in rat models of orofacial pain. ( Chichorro, JG; Hummig, W; Kopruszinski, CM, 2014) |
| "To assess the analgesic effect of pregabalin in orofacial models of acute inflammatory pain and of persistent pain associated with nerve injury and cancer, and so determine its effectiveness in controlling orofacial pains having different underlying mechanisms." | 7.80 | Pregabalin reduces acute inflammatory and persistent pain associated with nerve injury and cancer in rat models of orofacial pain. ( Chichorro, JG; Hummig, W; Kopruszinski, CM, 2014) |
| "Pregabalin produced a marked antinociceptive effect in rat models of facial inflammatory pain as well as in facial neuropathic and cancer pain models, suggesting that it may represent an important agent for the clinical control of orofacial pain." | 7.80 | Pregabalin reduces acute inflammatory and persistent pain associated with nerve injury and cancer in rat models of orofacial pain. ( Chichorro, JG; Hummig, W; Kopruszinski, CM, 2014) |
| "Latrunculin A microperfusion of the hippocampus induces acute epileptic seizures and long-term biochemical changes leading to spontaneous seizures." | 7.80 | Effects of eslicarbazepine acetate on acute and chronic latrunculin A-induced seizures and extracellular amino acid levels in the mouse hippocampus. ( Loureiro, AI; Sierra-Marcuño, G; Sierra-Paredes, G; Soares-da-Silva, P; Wright, LC, 2014) |
| "Oral administration of ESL (100 mg/kg), previous to latrunculin A microperfusion, completely prevented acute latrunculin A-induced seizures as well as chronic seizures and all EEG chronic signs of paroxysmal activity." | 7.80 | Effects of eslicarbazepine acetate on acute and chronic latrunculin A-induced seizures and extracellular amino acid levels in the mouse hippocampus. ( Loureiro, AI; Sierra-Marcuño, G; Sierra-Paredes, G; Soares-da-Silva, P; Wright, LC, 2014) |
| "ESL treatment prevented acute latrunculin A-induced seizures as well as chronic seizures and all EEG chronic signs of paroxysmal activity, supporting a possible anti-epileptogenic effect of ESL in mice." | 7.80 | Effects of eslicarbazepine acetate on acute and chronic latrunculin A-induced seizures and extracellular amino acid levels in the mouse hippocampus. ( Loureiro, AI; Sierra-Marcuño, G; Sierra-Paredes, G; Soares-da-Silva, P; Wright, LC, 2014) |
| " While seizures are usually intractable to medication in tuberous sclerosis complex (TSC), a common genetic cause of epilepsy, vigabatrin appears to have unique efficacy for epilepsy in TSC." | 7.79 | Vigabatrin inhibits seizures and mTOR pathway activation in a mouse model of tuberous sclerosis complex. ( McDaniel, SS; Rensing, NR; Wong, M; Zhang, B, 2013) |
| "The rostroventromedial medulla (RVM) is an important area of the endogenous pain-regulating system, in which 5-hydroxytryptamine (5-HT) and gamma-aminobutyric acid (GABA) are 2 main transmitters involved in pain modulation." | 7.79 | Neurokinin-1 receptor-expressing neurons that contain serotonin and gamma-aminobutyric acid in the rat rostroventromedial medulla are involved in pain processing. ( Chen, T; Li, YQ; Qu, J; Wang, W; Wang, XL; Wu, SX; Yanagawa, Y; Zhang, T, 2013) |
| " We have shown that perinatal exposure to bisphenol A (BPA) at environmental dose level causes long-term anxiety-like behaviors in rats." | 7.79 | Persistent overexpression of DNA methyltransferase 1 attenuating GABAergic inhibition in basolateral amygdala accounts for anxiety in rat offspring exposed perinatally to low-dose bisphenol A. ( Bai, Y; Chang, F; Chen, F; Chen, L; Zhou, R, 2013) |
| " We here investigated for the first time the effect of L-theanine intake on seizure susceptibility using acute pilocarpine and pentylenetetrazol (PTZ) mouse models for studying, respectively, limbic seizures or primarily generalized seizures." | 7.79 | L-Theanine intake increases threshold for limbic seizures but decreases threshold for generalized seizures. ( Loyens, E; Massie, A; Michotte, Y; Schallier, A; Smolders, I; Van Liefferinge, J; Vermoesen, K, 2013) |
| " We compared the efficacy of orally administered morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia with that on neuroma pain using the tibial neuroma transposition (TNT) model." | 7.78 | The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model. ( Miyazaki, R; Yamamoto, T, 2012) |
| "Morphine, pregabalin, gabapentin, and duloxetine attenuated the level of mechanical allodynia in a dose-dependent manner." | 7.78 | The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model. ( Miyazaki, R; Yamamoto, T, 2012) |
| "These data indicate that the potency of morphine and the efficacy of pregabalin, gabapentin, and duloxetine on mechanical allodynia are different from those on neuroma pain and that combination therapy is one of different therapeutic choices for the treatment of neuropathic pain." | 7.78 | The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model. ( Miyazaki, R; Yamamoto, T, 2012) |
| "The effect of the cyclooxygenase-2 (COX-2) inhibitor etodolac on the mechanical allodynia induced by paclitaxel was investigated in mice and compared with the effects of the nonselective COX inhibitors indomethacin and diclofenac, the selective COX-2 inhibitor celecoxib, the calcium channel α(2)δ subunit inhibitor pregabalin, the sodium channel blocker mexiletine, and the serotonin-norepinephrine reuptake inhibitor duloxetine." | 7.78 | Etodolac, a cyclooxygenase-2 inhibitor, attenuates paclitaxel-induced peripheral neuropathy in a mouse model of mechanical allodynia. ( Banno, K; Inoue, N; Ito, S; Kotera, T; Kyoi, T; Nakamura, A; Nogawa, M; Sasagawa, T; Tajima, K; Takahashi, Y; Ueda, M; Yamashita, Y, 2012) |
| " The von Frey filaments, acetone drop, and radiant heat test were performed to assess the degree of mechanical allodynia, thermal allodynia and thermal hyperalgesia respectively, at different time intervals, i." | 7.78 | Evaluation of aqueous and ethanolic extracts of saffron, Crocus sativus L., and its constituents, safranal and crocin in allodynia and hyperalgesia induced by chronic constriction injury model of neuropathic pain in rats. ( Amin, B; Hosseinzadeh, H, 2012) |
| "Glutaric acidemia type I (GA-I) is an inherited metabolic disease characterized by accumulation of glutaric acid (GA) and seizures." | 7.78 | m-Trifluoromethyl diphenyl diselenide attenuates glutaric acid-induced seizures and oxidative stress in rat pups: involvement of the γ-aminobutyric acidergic system. ( Brüning, CA; Fighera, MR; Gai, BM; Magni, DV; Nogueira, CW; Quines, CB; Rosa, SG, 2012) |
| "The aim of present study was to investigate the antinociceptive effect of pregabalin and tramadol either alone and or in combination on acute model of pain." | 7.78 | Pregabalin antinociception and its interaction with tramadol in acute model of pain. ( Keyhanfar, F; Meymandi, MS, 2012) |
| "Pregabalin revealed a comparative antinociceptive effect as similar to tramadol in acute model of pain, but interaction between these two drugs depends highly on their proportion in the combination." | 7.78 | Pregabalin antinociception and its interaction with tramadol in acute model of pain. ( Keyhanfar, F; Meymandi, MS, 2012) |
| "The aim of the present study was to investigate the possible antinociceptive effects of systemic administration of tramadol and gabapentin either alone or in combination on acute pain models in mice." | 7.78 | The antinociceptive effects of systemic administration of tramadol, gabapentin and their combination on mice model of acute pain. ( Alaçam, B; Aydin, ON; Ek, RO; Şen, S; Temoçin, S; Uğur, B, 2012) |
| "Epileptiform discharges recorded in the 4-aminopyridine (4-AP) in vitro epilepsy model are mediated by glutamatergic and GABAergic signaling." | 7.77 | The 4-aminopyridine in vitro epilepsy model analyzed with a perforated multi-electrode array. ( Avoli, M; Dzakpasu, R; Gonzalez-Sulser, A; Motamedi, GK; Vicini, S; Wang, J, 2011) |
| " The anticonvulsant gabapentin, which is widely used as an analgesic agent, also reduces anxiety." | 7.77 | The effects of gabapentin in two animal models of co-morbid anxiety and visceral hypersensitivity. ( Coelho, AM; Cryan, JF; Dinan, TG; Fitzgerald, P; Lee, K; O' Mahony, SM; Winchester, W, 2011) |
| "The present study was focused to characterize the effects of intrahippocampal application of R-verapamil, a P-glycoprotein blocker, and High Frequency Electrical Stimulation (HFS) at 130 Hz, on seizure susceptibility and extracellular concentrations of glutamate and γ-aminobutyric acid (GABA) in hippocampus of kindled rats with drug-resistant seizures." | 7.77 | Effects of high frequency electrical stimulation and R-verapamil on seizure susceptibility and glutamate and GABA release in a model of phenytoin-resistant seizures. ( Luna-Munguia, H; Orozco-Suarez, S; Rocha, L, 2011) |
| "Leptin acts in the brain to prevent obesity." | 7.77 | Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons. ( Choi, B; Chua, S; Lowell, BB; Vong, L; Yang, Z; Ye, C, 2011) |
| "The aim of the present study was to investigate the role of GABAergic and nitriergic modulation in the antianxiety effect of thymoquinone, a major constituent of Nigella sativa, in mice under unstressed and stressed conditions." | 7.77 | Thymoquinone produced antianxiety-like effects in mice through modulation of GABA and NO levels. ( Dhingra, D; Gilhotra, N, 2011) |
| "To evaluate the effects of high-frequency electrical stimulation (HFS) in both ventral hippocampi, alone and combined with a subeffective dose of antiepileptic drugs, during the status epilepticus (SE) induced by lithium-pilocarpine (LP)." | 7.76 | Antiepileptic drugs combined with high-frequency electrical stimulation in the ventral hippocampus modify pilocarpine-induced status epilepticus in rats. ( Alcantara-Gonzalez, D; Cuellar-Herrera, M; Neri-Bazan, L; Peña, F; Rocha, L, 2010) |
| " The present study evaluated the distribution pattern of GABAergic interneurons, especially parvalbumin (PV)- and somatostatin (SS)-immunopositive neurons, and excitatory propagation pattern in the IC of rats 4-7 days and 2 months after pilocarpine-induced status epilepticus (4-7 d and 2 m post-SE rats, respectively)." | 7.76 | Pilocarpine-induced status epilepticus causes acute interneuron loss and hyper-excitatory propagation in rat insular cortex. ( Chen, S; Fujita, S; Kobayashi, M; Koshikawa, N, 2010) |
| "Gabapentin, an anticonvulsant, is widely accepted as an alternative therapeutic agent for neuropathic pain and has proved to produce analgesic effects in a mouse model of visceral pain." | 7.76 | Analgesic effects of gabapentin on mechanical hypersensitivity in a rat model of chronic pancreatitis. ( Chen, H; Liao, XZ; Mao, YF; Sun, JH; Xiong, YC; Xu, H; Zhou, MT, 2010) |
| "The inhibitory transmitters GABA and glycine play an important role in modulating pain transmission, both in normal and in pathological situations." | 7.76 | Differential distribution of activated spinal neurons containing glycine and/or GABA and expressing c-fos in acute and chronic pain models. ( Duraku, LS; Holstege, JC; Hossaini, M; Jongen, JLM; Saraç, Ç, 2010) |
| "Evidence suggests an important role for supraspinal gamma-aminobutyric acid (GABA) in conditioned fear and pain." | 7.75 | Alterations in extracellular levels of gamma-aminobutyric acid in the rat basolateral amygdala and periaqueductal gray during conditioned fear, persistent pain and fear-conditioned analgesia. ( Finn, DP; Lang, Y; Rea, K, 2009) |
| "The effect of hyperhomocysteinemia induced by pretreatment with methionine 12 weeks prior to the study on the responses induced by gamma-aminobutyric acid (GABA), electrical field stimulation (EFS), and ATP have been evaluated in isolated rat duodenum." | 7.74 | Effects of hyperhomocysteinemia on non-adrenergic non-cholinergic relaxation in isolated rat duodenum. ( Karasu, E; Sadan, G; Tasatargil, A, 2008) |
| "To observe the effects of gamma-aminobutyric acid (GABA) on the electric activities of pain-excited neurons (PEN) in nucleus accumbens (NAc) in central nervous system (CNS) of morphine-dependent rats." | 7.74 | Modulation of gamma-aminobutyric acid on painful sense in central nervous system of morphine-dependent rats. ( Li, X; Xu, MY; Xu, Y, 2008) |
| "After GABA or the GABA(A)-receptor antagonist, bicuculline (Bic), was injected into cerebral ventricles or NAc, right sciatic nerve was stimulated by electrical pulses, which was considered as traumatic pain stimulation." | 7.74 | Modulation of gamma-aminobutyric acid on painful sense in central nervous system of morphine-dependent rats. ( Li, X; Xu, MY; Xu, Y, 2008) |
| "The effects of treatment with the anti-convulsant agents, lamotrigine and riluzole were compared with gabapentin in a rat experimental model of neuropathic pain." | 7.74 | A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain. ( Coderre, TJ; Kumar, N; Lefebvre, CD; Yu, JS, 2007) |
| "Pregabalin is used for treatment of neuropathic pain conditions." | 7.74 | Pregabalin reduces muscle and cutaneous hyperalgesia in two models of chronic muscle pain in rats. ( Audette, KM; Maeda, Y; Sluka, KA; Yokoyama, T, 2007) |
| "This study shows that pregabalin reduces both cutaneous and muscle hyperalgesia in inflammatory and noninflammatory models of muscle pain." | 7.74 | Pregabalin reduces muscle and cutaneous hyperalgesia in two models of chronic muscle pain in rats. ( Audette, KM; Maeda, Y; Sluka, KA; Yokoyama, T, 2007) |
| "Chronic lamotrigine, which is effective in the depressive phase or rapid cycling bipolar disorder does not alter brain arachidonic acid turnover in the unanesthetized rat." | 7.74 | Chronic lamotrigine does not alter the turnover of arachidonic acid within brain phospholipids of the unanesthetized rat: implications for the treatment of bipolar disorder. ( Bazinet, RP; Chang, L; Lee, HJ; Rao, JS; Rapoport, SI, 2007) |
| "Drugs that are effective in treating the manic phase of bipolar disorder (lithium, carbamazepine, and valproate) upon chronic administration to rats decrease the turnover of arachidonic acid in their brain phospholipids." | 7.74 | Chronic lamotrigine does not alter the turnover of arachidonic acid within brain phospholipids of the unanesthetized rat: implications for the treatment of bipolar disorder. ( Bazinet, RP; Chang, L; Lee, HJ; Rao, JS; Rapoport, SI, 2007) |
| "Activation of the laryngeal mucosa results in apnea that is mediated through, and can be elicited via electrical stimulation of, the superior laryngeal nerve (SLN)." | 7.74 | Activation of central adenosine A(2A) receptors enhances superior laryngeal nerve stimulation-induced apnea in piglets via a GABAergic pathway. ( Abu-Shaweesh, JM, 2007) |
| "These data demonstrated the comparable efficacy of gabapentin with morphine in visceral pain." | 7.74 | Gabapentin action and interaction on the antinociceptive effect of morphine on visceral pain in mice. ( Meymandi, MS; Sepehri, G, 2008) |
| "The anticonvulsant gabapentin (GBP) has been shown effective for the treatment of neuropathic pain, although its mechanism of action remains unclear." | 7.73 | Comparison of the antinociceptive profiles of gabapentin and 3-methylgabapentin in rat models of acute and persistent pain: implications for mechanism of action. ( Aiyar, J; Anker, N; Belley, M; Bristow, L; Campbell, B; Cohen, C; Park, KT; Ren, K; Stearns, B; Urban, MO, 2005) |
| "Not all neuropathic pain patients gain relief from current therapies that include the anticonvulsant, gabapentin, thought to modulate calcium channel function." | 7.73 | Spinal-supraspinal serotonergic circuits regulating neuropathic pain and its treatment with gabapentin. ( Dickenson, AH; Hunt, SP; Rahman, W; Rygh, LJ; Suzuki, R; Webber, M, 2005) |
| " Pilocarpine-induced status epilepticus (SE) was chosen as a model to generate chronic epileptic animals." | 7.73 | Septal GABAergic neurons are selectively vulnerable to pilocarpine-induced status epilepticus and chronic spontaneous seizures. ( Banuelos, C; Castañeda, MT; Colom, LV; Garrido Sanabria, ER; Hernandez, S; Perez-Cordova, MG, 2006) |
| " In this study the co-administration of gabapentin with morphine is evaluated in acute model of pain." | 7.73 | Gabapentin enhances the analgesic response to morphine in acute model of pain in male rats. ( Meymandi, MS; Mobasher, M; Sepehri, G, 2006) |
| "Limbic seizures were evoked in freely moving rats by intrahippocampal administration of pilocarpine via a microdialysis probe." | 7.73 | Substantia nigra is an anticonvulsant site of action of topiramate in the focal pilocarpine model of limbic seizures. ( Clinckers, R; Ebinger, G; Meurs, A; Michotte, Y; Smolders, I, 2006) |
| "Systemic and intranigral, but not intrahippocampal TPM administration suppressed pilocarpine-induced seizures and neurochemical changes." | 7.73 | Substantia nigra is an anticonvulsant site of action of topiramate in the focal pilocarpine model of limbic seizures. ( Clinckers, R; Ebinger, G; Meurs, A; Michotte, Y; Smolders, I, 2006) |
| "The release of [(3)H]D-aspartate ([(3)H]D-ASP) or [(3)H]GABA evoked by glycine from spinal cord synaptosomes was compared in mice expressing mutant human SOD1 with a Gly(93) Ala substitution ([SOD1-G93A(+)]), a transgenic model of amyotrophic lateral sclerosis, and in control mice." | 7.72 | Activation of a glycine transporter on spinal cord neurons causes enhanced glutamate release in a mouse model of amyotrophic lateral sclerosis. ( Bonanno, G; Paolucci, E; Prisco, S; Raiteri, L; Raiteri, M, 2003) |
| " Anticonvulsant effects were evaluated against seizures induced by 14 mg kg(-1) of 4-aminopyridine (4-AP) and by 110 mg kg(-1) of pentylenetetrazole (PTZ), and neurotoxicity by the rotarod test." | 7.72 | Is the interaction between felbamate and valproate against seizures induced by 4-aminopyridine and pentylenetetrazole in mice beneficial? ( Amat, G; Armijo, JA; Cuadrado, A, 2003) |
| " In this study, we investigated the kinetics of glutamate (GLU) and gamma-aminobutyric acid (GABA) in cerebrospinal fluid (CSF-GLU and CSF-GABA, respectively) using a high performance liquid chromatography (HPLC) in a canine model of complex partial status epilepticus (CPSE) induced by the microinjection of kainic acid (KA) into the unilateral amygdala." | 7.72 | Kinetics of glutamate and gamma-aminobutyric acid in cerebrospinal fluid in a canine model of complex partial status epilepticus induced by kainic acid. ( Fujita, M; Hasegawa, D; Matsuki, N; Ono, K; Orima, H, 2004) |
| "The effects of the gamma-aminobutyric acid (GABA)-potentiating drug gabapentin (1-(aminomethyl) cyclohexaneacetic acid) on severity of dystonia were examined in a hamster model of idiopathic paroxysmal dystonic choreoathetosis." | 7.70 | Gabapentin decreases the severity of dystonia at low doses in a genetic animal model of paroxysmal dystonic choreoathetosis. ( Löscher, W; Richter, A, 1999) |
| "The effects of muscimol, amino-oxyacetic acid (AOAA), diamino-N-butyric acid (DABA), bicuculline, picrotoxin, diazepam and phenobarbitone on the protective effect of clonidine against pentylenetetrazol-induced seizures were studied in mice." | 7.69 | gamma Aminobutyric acid mediation of the anticonvulsant effect of clonidine on pentylenetetrazol-induced seizures in mice. ( Amabeoku, G; Bwakura, E; Chikuni, O, 1994) |
| "Several similarities exist between the alterations observed in the chronic pilocarpine model of recurrent seizures in the rat and those found in human temporal lobe epilepsy." | 7.69 | Vulnerability and plasticity of the GABA system in the pilocarpine model of spontaneous recurrent seizures. ( Esclapez, M; Houser, CR, 1996) |
| " The neosynthesis of this amino acid from glucose was also studied in two experimental models of hepatic encephalopathy: (1) rats receiving large amounts of ammonium acetate (i." | 7.66 | The release and neosynthesis of glutamic acid are increased in experimental models of hepatic encephalopathy. ( Cortesini, C; Lombardi, G; Moneti, G; Moroni, F, 1983) |
| " It is now reported that membrane preparations from rats with mild galactosamine-induced hepatic encephalopathy show an increase in the number of low- and high-affinity gamma-aminobutyric acid binding sites, whereas those from rats with severe encephalopathy show only high-affinity binding sites." | 7.66 | Experimental hepatic encephalopathy: changes in the binding of gamma-aminobutyric acid. ( Baraldi, M; Zeneroli, ZL, 1982) |
| "Levetiracetam (Keppra) is an antiepileptic drug (AED) characterized by a novel mechanism of action, unique profile of activity in seizure models, and broad-spectrum clinical efficacy." | 6.45 | Benefit of combination therapy in epilepsy: a review of the preclinical evidence with levetiracetam. ( Kaminski, RM; Klitgaard, H; Matagne, A; Patsalos, PN, 2009) |
| "Gabapentin is a recently introduced antiepileptic drug for the treatment of partial seizures." | 6.40 | Gabapentin for treatment of epilepsy in children. ( Holmes, GL, 1997) |
| " Male offsprings were injected with EPO and NEPO in a clinically proper postnatal dosing regimen on postnatal days (PND) 1-5, and autistic-like behaviors were tested at the end of the first month." | 5.91 | The effects of postnatal erythropoietin and nano-erythropoietin on behavioral alterations by mediating K-Cl co-transporter 2 in the valproic acid-induced rat model of autism. ( Basiri, M; Darvishzadeh-Mahani, F; Haratizadeh, S; Nozari, M; Ranjbar, M, 2023) |
| " Pregnant C57BL/6 J mice were intraperitoneally injected with a dosage of 500 mg/kg valproic acid (VPA) on embryonic day 10." | 5.72 | Size anomaly and alteration of GABAergic enzymes expressions in cerebellum of a valproic acid mouse model of autism. ( Kwan, KM; Ma, SY, 2022) |
| "This study aimed to evaluate the efficacy of gamma-aminobutyric acid (GABA) alone or combined with praziquantel (PZQ) against Schistosoma (S) mansoni infection in a murine model." | 5.72 | Schistosomicidal and hepatoprotective activity of gamma-aminobutyric acid (GABA) alone or combined with praziquantel against Schistosoma mansoni infection in murine model. ( Fahmy, AM; Hegab, A; Tm, D; William, S, 2022) |
| " Significant improvement in hepatic oxidative stress levels, serum albumin and total protein in response to GABA treatment alone or combined with PZQ." | 5.72 | Schistosomicidal and hepatoprotective activity of gamma-aminobutyric acid (GABA) alone or combined with praziquantel against Schistosoma mansoni infection in murine model. ( Fahmy, AM; Hegab, A; Tm, D; William, S, 2022) |
| "Ketamine is a noncompetitive antagonist of N-methyl-D-aspartate receptors (NMDARs)." | 5.72 | Comprehensive metabolomic characterization of the hippocampus in a ketamine mouse model of schizophrenia. ( Cheng, A; Fan, W; Fu, Y; Liao, L; Wang, X; Wei, Y; Wen, D; Xiao, L; Yang, H; Ye, Y, 2022) |
| "VGB was administered for 3 and 7 days." | 5.56 | Long-term vigabatrin treatment modifies pentylenetetrazole-induced seizures in mice: focused on GABA brain concentration. ( Czuczwar, SJ; Krzyżanowski, M; Świąder, K; Świąder, MJ; Wróbel, A; Zakrocka, I; Łuszczki, JJ, 2020) |
| "Convulsions were evoked by PTZ at its CD97 (99 mg/kg)." | 5.56 | Long-term vigabatrin treatment modifies pentylenetetrazole-induced seizures in mice: focused on GABA brain concentration. ( Czuczwar, SJ; Krzyżanowski, M; Świąder, K; Świąder, MJ; Wróbel, A; Zakrocka, I; Łuszczki, JJ, 2020) |
| "Depression is one of the most common associated diseases, which aggravates psoriatic skin lesions and affects the life quality of patients." | 5.56 | Depressive-like behaviors in mice with Imiquimod-induced psoriasis. ( Di, T; Guo, J; Guo, X; Li, P; Liu, Y; Meng, Y; Qi, C; Wang, Y; Zhang, L; Zhao, J, 2020) |
| "Psoriasis is not only a chronic inflammatory skin disease but also a psychosomatic disorder." | 5.56 | Depressive-like behaviors in mice with Imiquimod-induced psoriasis. ( Di, T; Guo, J; Guo, X; Li, P; Liu, Y; Meng, Y; Qi, C; Wang, Y; Zhang, L; Zhao, J, 2020) |
| "The mainstay treatment for schizophrenia is antipsychotic drugs (APDs), which are mostly effective against the positive symptoms (e." | 5.51 | Effect of cannabidiol on endocannabinoid, glutamatergic and GABAergic signalling markers in male offspring of a maternal immune activation (poly I:C) model relevant to schizophrenia. ( Babic, I; Huang, XF; Lum, JS; Newell, KA; Osborne, AL; Solowij, N; Weston-Green, K, 2019) |
| " We investigated the effect of long-term administration of ERI in three different doses on behavioral changes, hippocampal and prefrontal cortex (PFC) neurogenesis, and γ-aminobutyric acid (GABA)/glutamate balance in male Wistar rats exposed to chronic restraint stress (CRS)." | 5.48 | Behavioral effects of toll-like receptor-4 antagonist 'eritoran' in an experimental model of depression: role of prefrontal and hippocampal neurogenesis and γ-aminobutyric acid/glutamate balance. ( Aboul-Fotouh, S; Asaad, T; Ghanem, MH; Habib, M; Kassim, SK, 2018) |
| "Depression is the disease of the modern era." | 5.48 | Behavioral effects of toll-like receptor-4 antagonist 'eritoran' in an experimental model of depression: role of prefrontal and hippocampal neurogenesis and γ-aminobutyric acid/glutamate balance. ( Aboul-Fotouh, S; Asaad, T; Ghanem, MH; Habib, M; Kassim, SK, 2018) |
| "Epilepsy is associated with increased morbidity and mortality together and places a large financial burden on individuals and society." | 5.48 | Anticonvulsive effects of protodioscin against pilocarpine-induced epilepsy. ( Chen, Y; Fajol, A; Ren, B; Shi, S; Song, S, 2018) |
| "Chronic pain, neuropathic pain, inflammatory pain, ozone therapy, interventional therapy, gabapentin, spared nerve injury, bee venom, complete Freud's adjuvant." | 5.46 | Intervertebral Foramen Injection of Ozone Relieves Mechanical Allodynia and Enhances Analgesic Effect of Gabapentin in Animal Model of Neuropathic Pain. ( Chen, J; Guan, SM; Luo, WJ; Sun, W; Wang, JL; Wang, JS; Wang, XL; Wu, FF; Yang, F; Zheng, W, 2017) |
| "The novel therapeutic strategy against autism is essential due to the limited therapeutic efficacy." | 5.46 | Laser Acupuncture at HT7 Improves the Cerebellar Disorders in Valproic Acid-Rat Model of Autism. ( Khongrum, J; Wattanathorn, J, 2017) |
| "Gabapentin gel (10% w/w) was applied three times daily on the ipsilateral or contralateral plantar surface of the hind-paw, whereas in a concurrent systemic study, gabapentin was intraperitoneally administered daily (75 mg/kg) for 30 days." | 5.46 | Topical gabapentin gel alleviates allodynia and hyperalgesia in the chronic sciatic nerve constriction injury neuropathic pain model. ( Ahmad, N; Akbar, S; Ali, G; Fawad, K; Sewell, RD; Shahid, M; Subhan, F, 2017) |
| "Tests for static- and dynamic-mechano-allodynia [paw withdrawal threshold (PWT) to von Frey filament application and latency (PWL) to light brushing], cold-allodynia [paw withdrawal duration (PWD) to acetone], heat- (PWL and PWD) and mechano-hyperalgesia (PWD to pin prick) were utilized to assess pain, whereas effects on locomotion (open field) and motor balance (rotarod and footprint analysis) were measured on days 5-30 post surgery." | 5.46 | Topical gabapentin gel alleviates allodynia and hyperalgesia in the chronic sciatic nerve constriction injury neuropathic pain model. ( Ahmad, N; Akbar, S; Ali, G; Fawad, K; Sewell, RD; Shahid, M; Subhan, F, 2017) |
| "Systemic gabapentin neuropathic pain management carries side-effects ostensibly preventable by localized therapy." | 5.46 | Topical gabapentin gel alleviates allodynia and hyperalgesia in the chronic sciatic nerve constriction injury neuropathic pain model. ( Ahmad, N; Akbar, S; Ali, G; Fawad, K; Sewell, RD; Shahid, M; Subhan, F, 2017) |
| "Chronic pain is a multifactorial disease comprised of both inflammatory and neuropathic components that affect ∼20% of the world's population." | 5.46 | sec-Butylpropylacetamide (SPD), a new amide derivative of valproic acid for the treatment of neuropathic and inflammatory pain. ( Bialer, M; Brennan, KC; Devor, M; Kaufmann, D; Smith, MD; West, PJ; White, HS; Yagen, B, 2017) |
| "Both phases display robust tactile allodynia." | 5.43 | The effect of gabapentin and ketorolac on allodynia and conditioned place preference in antibody-induced inflammation. ( Corr, M; McQueen, J; Park, HJ; Sandor, K; Svensson, CI; Woller, SA; Yaksh, TL, 2016) |
| "After onset of inflammation and allodynia, we assessed effects of i." | 5.43 | The effect of gabapentin and ketorolac on allodynia and conditioned place preference in antibody-induced inflammation. ( Corr, M; McQueen, J; Park, HJ; Sandor, K; Svensson, CI; Woller, SA; Yaksh, TL, 2016) |
| "Consistent with the effects upon allodynia, both gabapentin and ketorolac produced a preference for the drug-paired compartment in the early phase of the K/BxN model, while gabapentin, but not ketorolac, resulted in a place preference during late phase." | 5.43 | The effect of gabapentin and ketorolac on allodynia and conditioned place preference in antibody-induced inflammation. ( Corr, M; McQueen, J; Park, HJ; Sandor, K; Svensson, CI; Woller, SA; Yaksh, TL, 2016) |
| "The results confirm activity in chronic pain models predicted from affinity for the gabapentin site and suggests, at least partially, that α2δ-subunits of presynaptic voltage-gated calcium channels are involved in mediating this effect." | 5.43 | Optical isomers of phenibut inhibit [H(3)]-Gabapentin binding in vitro and show activity in animal models of chronic pain. ( Belozertseva, I; Danysz, W; Franke, L; Nagel, J; Valastro, B, 2016) |
| "Sulforaphane promotes polarization of microglia from the M1 to the M2 phenotype, reducing IL-1b and increasing IL-4, IL-10, Arg1, and YM-1 in the cerebellum." | 5.43 | Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia. ( Agusti, A; Balzano, T; Cabrera-Pastor, A; Felipo, V; Gonzalez-Usano, A; Hernandez-Rabaza, V; Llansola, M; Taoro-Gonzalez, L, 2016) |
| "Cathepsin S inhibitors attenuate mechanical allodynia in preclinical neuropathic pain models." | 5.43 | Selective Cathepsin S Inhibition with MIV-247 Attenuates Mechanical Allodynia and Enhances the Antiallodynic Effects of Gabapentin and Pregabalin in a Mouse Model of Neuropathic Pain. ( Classon, B; Edenius, C; Grabowska, U; Henderson, I; Hewitt, E; Lindström, E; Malcangio, M; Pitcher, T; Rizoska, B; Sahlberg, BL; Tunblad, K, 2016) |
| "Mechanical allodynia was assessed using von Frey hairs." | 5.43 | Selective Cathepsin S Inhibition with MIV-247 Attenuates Mechanical Allodynia and Enhances the Antiallodynic Effects of Gabapentin and Pregabalin in a Mouse Model of Neuropathic Pain. ( Classon, B; Edenius, C; Grabowska, U; Henderson, I; Hewitt, E; Lindström, E; Malcangio, M; Pitcher, T; Rizoska, B; Sahlberg, BL; Tunblad, K, 2016) |
| " Systemic nicotine given before the sample phase of the CMOR task reversed the ketamine-induced impairment, but this effect was blocked by co-administration of the GABAA receptor antagonist bicuculline at a dosage that itself did not cause impairment." | 5.42 | α₄β₂ Nicotinic receptor stimulation of the GABAergic system within the orbitofrontal cortex ameliorates the severe crossmodal object recognition impairment in ketamine-treated rats: implications for cognitive dysfunction in schizophrenia. ( Cloke, JM; Winters, BD, 2015) |
| "Schizophrenia is associated with atypical multisensory integration." | 5.42 | α₄β₂ Nicotinic receptor stimulation of the GABAergic system within the orbitofrontal cortex ameliorates the severe crossmodal object recognition impairment in ketamine-treated rats: implications for cognitive dysfunction in schizophrenia. ( Cloke, JM; Winters, BD, 2015) |
| "Neuropathic vulvodynia is a state of vulval discomfort characterized by a burning sensation, diffuse pain, pruritus or rawness with an acute or chronic onset." | 5.42 | A streptozotocin-induced diabetic neuropathic pain model for static or dynamic mechanical allodynia and vulvodynia: validation using topical and systemic gabapentin. ( Abbas, M; Ali, G; Sewell, RD; Shahid, M; Subhan, F; Zeb, J, 2015) |
| "Diazepam was employed as standard anxiolytic drug." | 5.40 | Possible involvement of GABAergic and nitriergic systems for antianxiety-like activity of piperine in unstressed and stressed mice. ( Dhingra, D; Gilhotra, N, 2014) |
| "While seizures are usually intractable to medication in tuberous sclerosis complex (TSC), a common genetic cause of epilepsy, vigabatrin appears to have unique efficacy for epilepsy in TSC." | 5.39 | Vigabatrin inhibits seizures and mTOR pathway activation in a mouse model of tuberous sclerosis complex. ( McDaniel, SS; Rensing, NR; Wong, M; Zhang, B, 2013) |
| "Although antiseizure medication is the first-line treatment for epilepsy, currently available medications are ineffective in a significant percentage of patients and have not clearly been demonstrated to have disease-specific effects for epilepsy." | 5.39 | Vigabatrin inhibits seizures and mTOR pathway activation in a mouse model of tuberous sclerosis complex. ( McDaniel, SS; Rensing, NR; Wong, M; Zhang, B, 2013) |
| "Gabapentin was used to provide an anxiolytic effect on drug-free days." | 5.38 | Evaluation of anxiolytic effect and withdrawal anxiety in chronic intermittent diazepam treatment in rats. ( Açikmeşe, B; Enginar, N; Hatipoğlu, I; Haznedar, S, 2012) |
| "This study evaluated the effect of intermittent administration in the development of dependence to diazepam in chronic use of the drug." | 5.38 | Evaluation of anxiolytic effect and withdrawal anxiety in chronic intermittent diazepam treatment in rats. ( Açikmeşe, B; Enginar, N; Hatipoğlu, I; Haznedar, S, 2012) |
| "Morphine was less potent in neuroma pain than in mechanical allodynia." | 5.38 | The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model. ( Miyazaki, R; Yamamoto, T, 2012) |
| "After TNT injury, mechanical allodynia and neuroma pain are observed." | 5.38 | The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model. ( Miyazaki, R; Yamamoto, T, 2012) |
| "It has been reported that <50% of neuropathic pain patients are satisfactorily treated with drugs." | 5.38 | The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model. ( Miyazaki, R; Yamamoto, T, 2012) |
| " As a corollary, they also show that long-term use of ETH and GAB is devoid of adverse behavioral and cognitive effects." | 5.38 | Lack of behavioral and cognitive effects of chronic ethosuximide and gabapentin treatment in the Ts65Dn mouse model of Down syndrome. ( Corrales, A; Flórez, J; García, S; Martínez, P; Martínez-Cué, C; Rueda, N; Sharma, A; Vidal, V, 2012) |
| "When gabapentin and tramadol were used in combination, gabapentin had no additive antinociceptive effect except for 300 mg/kg in tail-flick and hot-plate tests." | 5.38 | The antinociceptive effects of systemic administration of tramadol, gabapentin and their combination on mice model of acute pain. ( Alaçam, B; Aydin, ON; Ek, RO; Şen, S; Temoçin, S; Uğur, B, 2012) |
| "Behavioural assessments of tail muscle spasticity and mean arterial blood pressure responses to noxious somatic and/or visceral stimulation were used to test the effects of GBP on these abnormal reflexes." | 5.37 | Gabapentin for spasticity and autonomic dysreflexia after severe spinal cord injury. ( Duale, H; Kitzman, PH; Lyttle, TS; O'Dell, CR; Patel, SP; Rabchevsky, AG, 2011) |
| "Pre-treatment with methylene blue enhanced the antianxiety effect of thymoquinone in both unstressed and stressed mice." | 5.37 | Thymoquinone produced antianxiety-like effects in mice through modulation of GABA and NO levels. ( Dhingra, D; Gilhotra, N, 2011) |
| "To evaluate the effects of high-frequency electrical stimulation (HFS) in both ventral hippocampi, alone and combined with a subeffective dose of antiepileptic drugs, during the status epilepticus (SE) induced by lithium-pilocarpine (LP)." | 5.36 | Antiepileptic drugs combined with high-frequency electrical stimulation in the ventral hippocampus modify pilocarpine-induced status epilepticus in rats. ( Alcantara-Gonzalez, D; Cuellar-Herrera, M; Neri-Bazan, L; Peña, F; Rocha, L, 2010) |
| " One minute following pilocarpine injection, HFS (pulses of 60 mus width at 130 Hz at subthreshold intensities and applied during 3 h) was applied alone or combined with subeffective doses of antiepileptic drugs." | 5.36 | Antiepileptic drugs combined with high-frequency electrical stimulation in the ventral hippocampus modify pilocarpine-induced status epilepticus in rats. ( Alcantara-Gonzalez, D; Cuellar-Herrera, M; Neri-Bazan, L; Peña, F; Rocha, L, 2010) |
| " This effect was not evident when HFS was combined with phenytoin (33." | 5.36 | Antiepileptic drugs combined with high-frequency electrical stimulation in the ventral hippocampus modify pilocarpine-induced status epilepticus in rats. ( Alcantara-Gonzalez, D; Cuellar-Herrera, M; Neri-Bazan, L; Peña, F; Rocha, L, 2010) |
| "In both neuropathic pain models, rats exhibited mechanical hypersensitivity, whereas a significant increase in anxiety-like behaviour was observed only in CCI rats (time spent in open arms decreased significantly from 99+/-15." | 5.35 | Anxiety-like behaviour in rats with mononeuropathy is reduced by the analgesic drugs morphine and gabapentin. ( Arndt, K; Ceci, A; Doods, H; Roeska, K; Treede, RD, 2008) |
| "Neuropathic pain was induced in rats by partial sciatic nerve ligation (PNL) and chronic constriction injury (CCI)." | 5.35 | Anxiety-like behaviour in rats with mononeuropathy is reduced by the analgesic drugs morphine and gabapentin. ( Arndt, K; Ceci, A; Doods, H; Roeska, K; Treede, RD, 2008) |
| "Epilepsy is a serious neurological disorder in human beings and the long-term pathological events remain largely obscure." | 5.35 | Time-course of neuronal death in the mouse pilocarpine model of chronic epilepsy using Fluoro-Jade C staining. ( Chen, LW; Huang, YG; Liu, YH; Wang, L, 2008) |
| "No causal treatment of ataxias is available at the moment, and so symptomatic and disease-modifying therapies are regarded as a reliable possibility for this complex group of movement disorders." | 5.35 | Gabapentin treatment improves motor coordination in a mice model of progressive ataxia. ( Calzà, L; D'Intino, G; Ferraro, L; Giardino, L; Gusciglio, M; Massella, A; Sivilia, S, 2009) |
| "Visceral pain is one of the most common forms of pain and for which new drugs would be welcome." | 5.35 | Gabapentin action and interaction on the antinociceptive effect of morphine on visceral pain in mice. ( Meymandi, MS; Sepehri, G, 2008) |
| "Acute seizure activity was behaviorally scored and hemispheric brain atrophy measured." | 5.35 | Gabapentin neuroprotection and seizure suppression in immature mouse brain ischemia. ( Comi, AM; Johnston, MV; Kadam, SD; Mulholland, JD; Traa, BS, 2008) |
| "Muscle hyperalgesia (withdrawal threshold to compression of the muscle) and cutaneous hyperalgesia of the paw (withdrawal threshold to von Frey filaments) were measured before and after induction of hyperalgesia and after treatment with pregabalin (saline, 10 to 100 mg/kg i." | 5.34 | Pregabalin reduces muscle and cutaneous hyperalgesia in two models of chronic muscle pain in rats. ( Audette, KM; Maeda, Y; Sluka, KA; Yokoyama, T, 2007) |
| "Drugs that are effective in treating the manic phase of bipolar disorder (lithium, carbamazepine, and valproate) upon chronic administration to rats decrease the turnover of arachidonic acid in their brain phospholipids." | 5.34 | Chronic lamotrigine does not alter the turnover of arachidonic acid within brain phospholipids of the unanesthetized rat: implications for the treatment of bipolar disorder. ( Bazinet, RP; Chang, L; Lee, HJ; Rao, JS; Rapoport, SI, 2007) |
| "Mefloquine dose dependently induced tonic seizures in mice." | 5.33 | Gamma-aminobutyric acid and mefloquine-induced seizures in mice. ( Amabeoku, GJ; Farmer, CC, 2005) |
| "In vivo, it potently prevents seizures, pain-related behaviors and has anxiolytic-like activity in rodent models." | 5.33 | Activity profile of pregabalin in rodent models of epilepsy and ataxia. ( Bertram, E; Kinsora, JJ; Radulovic, LL; Serpa, KA; Taylor, CP; Vartanian, MG; Vergnes, M, 2006) |
| "Limbic seizures were evoked in freely moving rats by intrahippocampal administration of pilocarpine via a microdialysis probe." | 5.33 | Substantia nigra is an anticonvulsant site of action of topiramate in the focal pilocarpine model of limbic seizures. ( Clinckers, R; Ebinger, G; Meurs, A; Michotte, Y; Smolders, I, 2006) |
| "The degree of allodynia was most marked following 10 min of irradiation." | 5.32 | Gabapentin reverses mechanical allodynia induced by sciatic nerve ischemia and formalin-induced nociception in mice. ( Berge, OG; Brodin, E; Flood, K; Gustafsson, H; Olgart, L; Stiller, CO, 2003) |
| " This dosage produced a substantial but non-significant decrease in the incidence of postherpetic pain-related responses." | 5.32 | Effects of the suppression of acute herpetic pain by gabapentin and amitriptyline on the incidence of delayed postherpetic pain in mice. ( Kuraishi, Y; Nojima, H; Shiraki, K; Takahata, H; Takasaki, I, 2004) |
| "tended to decrease seizure intensity and at a dose of 10 mg/kg was ineffective at all." | 5.29 | Further evidence for the interactions between angiotensin II and GABAergic transmission in pentylenetetrazol kindling seizures in mice. ( Georgiev, VP; Kambourova, TS; Lazarova, MB, 1995) |
| "Thus, hepatic encephalopathy appears to involve partial degeneration of the gamma-aminobutyric acid-containing presynaptic nerve terminals." | 5.26 | Experimental hepatic encephalopathy: changes in the binding of gamma-aminobutyric acid. ( Baraldi, M; Zeneroli, ZL, 1982) |
| "Penicillin seizures do not cause a change in levels of GABA, but result in a decrease in glutamate within the focus." | 5.26 | Effect of amino-oxyacetic acid (AOAA) on focal penicillin seizures. ( Collins, RC; Mehta, S, 1978) |
| "This paper reviews recent research on the contribution of the proinflammatory cytokine interleukin-1 (IL- 1) and the purine nucleoside adenosine in mediating behavioral depression and related symptoms of conservation-withdrawal in animal models of both major depression and illness." | 4.86 | Biochemical and anatomical substrates of depression and sickness behavior. ( Furst, SJ; Hanff, TC; Minor, TR, 2010) |
| "In this study, based on the excitatory/inhibitory imbalance theory of autism, the time window of GABA switch, the role of K-Cl co-transporter 2 (KCC2) in adjustment GABA switch, and brain permeability to erythropoietin (EPO), the effects of postnatal -EPO and- nano- erythropoietin (NEPO) have been evaluated in the valproic acid (VPA) rat model of autism." | 4.31 | The effects of postnatal erythropoietin and nano-erythropoietin on behavioral alterations by mediating K-Cl co-transporter 2 in the valproic acid-induced rat model of autism. ( Basiri, M; Darvishzadeh-Mahani, F; Haratizadeh, S; Nozari, M; Ranjbar, M, 2023) |
| "Although escitalopram is known to be an effective drug for adult depression, its disease-modifying efficacy on adolescents remains controversial." | 4.31 | Effects of Escitalopram on the Functional Neural Circuits in an Animal Model of Adolescent Depression. ( Choi, JY; Han, SJ; Kang, KJ; Lee, N; Nam, KR; Oh, SJ, 2023) |
| "The administration of escitalopram had no therapeutic effect on the adolescent depression." | 4.31 | Effects of Escitalopram on the Functional Neural Circuits in an Animal Model of Adolescent Depression. ( Choi, JY; Han, SJ; Kang, KJ; Lee, N; Nam, KR; Oh, SJ, 2023) |
| " Prolonged supplementation with both melatonin and SkQ1 (separately) suppressed the progression of the AMD-like pathology in OXYS rats without affecting the glutamate/GABA system but worsened the condition of the Wistar rat's retina during normal aging." | 4.12 | The glutamate/GABA system in the retina of male rats: effects of aging, neurodegeneration, and supplementation with melatonin and antioxidant SkQ1. ( Antonenko, AK; Fursova, AZ; Kolosova, NG; Telegina, DV, 2022) |
| " We generated GABAergic interneuron precursors from human embryonic stem cells (hESCs) and grafted them in the hippocampi of rats developing chronic SRSs after kainic acid-induced status epilepticus." | 4.02 | Human Stem Cell-Derived GABAergic Interneurons Establish Efferent Synapses onto Host Neurons in Rat Epileptic Hippocampus and Inhibit Spontaneous Recurrent Seizures. ( Andersson, M; Gonzalez-Ramos, A; Kokaia, M; Kudláček, J; Ledri, M; Mikroulis, A; Waloschková, E, 2021) |
| "The goal of our study was to examine the long-term effect of vigabatrin (VGB), a γ-aminobutyric acid aminotransferase (GABA-AT) inhibitor on clonazepam (CLO), ethosuximide (ETX) and valproate (VPA) anticonvulsive activity against pentylenetetrazole (PTZ)-induced seizures in mice." | 3.96 | Long-term vigabatrin treatment modifies pentylenetetrazole-induced seizures in mice: focused on GABA brain concentration. ( Czuczwar, SJ; Krzyżanowski, M; Świąder, K; Świąder, MJ; Wróbel, A; Zakrocka, I; Łuszczki, JJ, 2020) |
| "To induce ALF, C57BL/6NHsd mice were administered GABA, saline, or nothing for 7 d, followed by intraperitoneal administration of 500 μg of tumor necrosis factor α and 20 mg of D-galactosamine." | 3.91 | GABA, γ-Aminobutyric Acid, Protects Against Severe Liver Injury. ( Hata, T; Hori, T; Nguyen, JH; Rehman, F, 2019) |
| " Mechanical allodynia and thermal hyperalgesia were measured to confirm neuropathic pain induction following before and after gabapentin (GBP) treatment." | 3.88 | Investigation of spinal nerve ligation-mediated functional activation of the rat brain using manganese-enhanced MRI. ( Jeong, KY; Kang, JH, 2018) |
| "Absence seizures (ASs) are associated with abnormalities in gamma-aminobutyric acid (GABA) neurotransmission in the thalamus and the cortex." | 3.88 | Developmental changes of GABA immunoreactivity in cortico-thalamic networks of an absence seizure model. ( Bombardi, C; Crunelli, V; Di Giovanni, G; Venzi, M, 2018) |
| " We found that 24-h after CFA-induced knee inflammation, knee neurons show a decreased action potential generation threshold, as well as increased GABA and capsaicin sensitivity, but have unaltered acid sensitivity." | 3.88 | Acute inflammation sensitizes knee-innervating sensory neurons and decreases mouse digging behavior in a TRPV1-dependent manner. ( Callejo, G; Chakrabarti, S; Hockley, JRF; Pattison, LA; Singhal, K; Smith, ESJ, 2018) |
| " However, the neuroprotective effects and the mechanism of action of PNU-282987, an α7-nAChR agonist, in a chronic in vivo rat glaucoma model are poorly understood." | 3.85 | Alpha7 nicotinic acetylcholine receptor agonist promotes retinal ganglion cell function via modulating GABAergic presynaptic activity in a chronic glaucomatous model. ( Cheng, Y; Li, G; Wu, J; Yang, B; Zhang, R; Zhang, S; Zhou, X, 2017) |
| "In a 5-year follow-up study in a hospital in southern China, it was shown that intervertebral foramen (IVF) injection of ozone at the involved segmental levels could significantly alleviate paroxysmal spontaneous pain and mechanical allodynia in patients with chronic, intractable postherpetic neuralgia (PHN) and improve the quality of life." | 3.85 | Intervertebral Foramen Injection of Ozone Relieves Mechanical Allodynia and Enhances Analgesic Effect of Gabapentin in Animal Model of Neuropathic Pain. ( Chen, J; Guan, SM; Luo, WJ; Sun, W; Wang, JL; Wang, JS; Wang, XL; Wu, FF; Yang, F; Zheng, W, 2017) |
| "(1) IVF injection of ozone at L4-5 was only effective in suppression of mechanical allodynia in rats with neuropathic pain but not with inflammatory pain; (2) the analgesic effects of IVF ozone lasted much longer (> 14 days) than other selective molecular target drugs (< 48 hours) inhibiting or antagonizing at Nav1." | 3.85 | Intervertebral Foramen Injection of Ozone Relieves Mechanical Allodynia and Enhances Analgesic Effect of Gabapentin in Animal Model of Neuropathic Pain. ( Chen, J; Guan, SM; Luo, WJ; Sun, W; Wang, JL; Wang, JS; Wang, XL; Wu, FF; Yang, F; Zheng, W, 2017) |
| "Transplantation of progenitor cells from embryonic medial or caudal ganglionic eminence (MGE, CGE) were made in a well-characterized mouse model of status epilepticus-induced epilepsy (systemic pilocarpine)." | 3.85 | Persistent seizure control in epileptic mice transplanted with gamma-aminobutyric acid progenitors. ( Baraban, SC; Casalia, ML; Howard, MA, 2017) |
| "The combination of low-dose KML29:gabapentin additively attenuated mechanical allodynia and synergistically reduced cold allodynia." | 3.85 | The monoacylglycerol lipase inhibitor KML29 with gabapentin synergistically produces analgesia in mice. ( Banks, ML; Bradshaw, HB; Crowe, MS; Kinsey, SG; Leishman, E; Prather, PL; Wilson, CD, 2017) |
| "Gabapentin is commonly prescribed for nerve pain but may also cause dizziness, sedation and gait disturbances." | 3.85 | The monoacylglycerol lipase inhibitor KML29 with gabapentin synergistically produces analgesia in mice. ( Banks, ML; Bradshaw, HB; Crowe, MS; Kinsey, SG; Leishman, E; Prather, PL; Wilson, CD, 2017) |
| "Topical application of gabapentin gel ipsilaterally but not contralaterally alleviated CCI-induced static- (days 10-30) and dynamic-allodynia (days 15-30), suppressed cold-allodynia (days 10-30), heat- (days 15-30) and mechano-hyperalgesia (days 5-30) indicating a local action." | 3.85 | Topical gabapentin gel alleviates allodynia and hyperalgesia in the chronic sciatic nerve constriction injury neuropathic pain model. ( Ahmad, N; Akbar, S; Ali, G; Fawad, K; Sewell, RD; Shahid, M; Subhan, F, 2017) |
| "Carvacrol, a naturally occurring inhibitor of TRPM7 channels, is a novel, promising treatment to prevent early recurrence of SE, SE-related neuronal damage, and cognitive decline." | 3.85 | Carvacrol after status epilepticus (SE) prevents recurrent SE, early seizures, cell death, and cognitive decline. ( Khalil, A; Kovac, S; Morris, G; Walker, MC, 2017) |
| " Because the involvement of local inhibition in the dorsal horn, specifically that mediated by the inhibitory amino acids GABA and glycine, is so important in signal processing, we investigated regional inhibitory control of excitatory interneurons under control conditions and peripheral inflammation-induced mechanical allodynia." | 3.85 | Inhibition Mediated by Glycinergic and GABAergic Receptors on Excitatory Neurons in Mouse Superficial Dorsal Horn Is Location-Specific but Modified by Inflammation. ( Choudhury, P; Conway, CM; Flood, PD; MacDermott, AB; Mukai, J; Scherrer, G; Takazawa, T; Tong, CK, 2017) |
| " Daily gabapentin treatment attenuated mechanical allodynia and reduced face-grooming episodes in dIoN-CCI rats." | 3.85 | An Improved Rodent Model of Trigeminal Neuropathic Pain by Unilateral Chronic Constriction Injury of Distal Infraorbital Nerve. ( Chen, L; Ding, W; Doheny, JT; Lim, G; Mao, J; Shen, S; Yang, J; You, Z; Zhu, S, 2017) |
| "Consistent with the effects upon allodynia, both gabapentin and ketorolac produced a preference for the drug-paired compartment in the early phase of the K/BxN model, while gabapentin, but not ketorolac, resulted in a place preference during late phase." | 3.83 | The effect of gabapentin and ketorolac on allodynia and conditioned place preference in antibody-induced inflammation. ( Corr, M; McQueen, J; Park, HJ; Sandor, K; Svensson, CI; Woller, SA; Yaksh, TL, 2016) |
| "The important pathological consequences of insulin resistance arise from the detrimental effects of accumulated long-chain fatty acids and their respective acylcarnitines." | 3.83 | Decreased acylcarnitine content improves insulin sensitivity in experimental mice models of insulin resistance. ( Dambrova, M; Grinberga, S; Kuka, J; Liepinsh, E; Makarova, E; Makrecka-Kuka, M; Sevostjanovs, E; Svalbe, B; Volska, K, 2016) |
| "Monosodium glutamate (MSG), a flavor enhancer used in food, administered to neonatal rats causes neuronal lesions and leads to anxiety when adulthood." | 3.83 | Diphenyl diselenide ameliorates monosodium glutamate induced anxiety-like behavior in rats by modulating hippocampal BDNF-Akt pathway and uptake of GABA and serotonin neurotransmitters. ( Nogueira, CW; Quines, CB; Rosa, SG; Stangherlin, EC, 2016) |
| "Based on clinical studies regarding the beneficial effect of gabapentin in depression, we aimed to evaluate the antidepressant-like properties of gabapentin in mice and also the participation of nitric oxide (NO)/cyclic guanosine monophosphate pathway in this effect." | 3.83 | Involvement of NO/cGMP pathway in the antidepressant-like effect of gabapentin in mouse forced swimming test. ( Akhlaghipour, G; Ameli, S; Dehpour, A; Haj-Mirzaian, A; Kordjazy, N; Ostadhadi, S, 2016) |
| "The results confirm activity in chronic pain models predicted from affinity for the gabapentin site and suggests, at least partially, that α2δ-subunits of presynaptic voltage-gated calcium channels are involved in mediating this effect." | 3.83 | Optical isomers of phenibut inhibit [H(3)]-Gabapentin binding in vitro and show activity in animal models of chronic pain. ( Belozertseva, I; Danysz, W; Franke, L; Nagel, J; Valastro, B, 2016) |
| " Sulforaphane could be a new therapeutic approach to improve cognitive and motor function in hyperammonemia, hepatic encephalopathy, and other pathologies associated with neuroinflammation by promoting microglia differentiation from M1 to M2." | 3.83 | Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia. ( Agusti, A; Balzano, T; Cabrera-Pastor, A; Felipo, V; Gonzalez-Usano, A; Hernandez-Rabaza, V; Llansola, M; Taoro-Gonzalez, L, 2016) |
| " Based on this, the aim of the present study was to investigate the effect of magnesium on the level of glutamic acid decarboxylase-67kDa (GAD-67) in the different brain areas in the chronic mild stress (CMS) and olfactory bulbectomy (OB) models of depression in rats." | 3.83 | Brain glutamic acid decarboxylase-67kDa alterations induced by magnesium treatment in olfactory bulbectomy and chronic mild stress models in rats. ( Nowak, G; Pochwat, B; Szewczyk, B, 2016) |
| ") gabapentin (GBP), carbamazepine (CBZ) and 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) on learning and memory, anxiety, and locomotor activity in rats with lithium-pilocarpine-induced status epilepticus (SE)." | 3.83 | Immediate and delayed treatment with gabapentin, carbamazepine and CNQX have almost similar impact on cognitive functions and behavior in the lithium-pilocarpine model in rats. ( Gulec Suyen, G; Isbil-Buyukcoskun, N; Kahveci, N; Ozluk, K; Sengun, E, 2016) |
| " Mechanical allodynia elicited by burn injury was partially reversed by meloxicam (5 mg/kg), gabapentin (100 mg/kg) and oxycodone (3 and 10 mg/kg), while thermal allodynia and gait abnormalities were only significantly improved by amitriptyline (3 mg/kg) and oxycodone (10 mg/kg)." | 3.83 | Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target. ( Deuis, JR; Lewis, RJ; Vetter, I; Yin, K, 2016) |
| "Proline dehydrogenase (PRODH), which degrades L-proline, resides within the schizophrenia-linked 22q11." | 3.83 | Cytosolic Accumulation of L-Proline Disrupts GABA-Ergic Transmission through GAD Blockade. ( Crabtree, GW; Gogos, JA; Gordon, JA; Park, AJ, 2016) |
| " Sleep disruption-induced hypersensitivity was pharmacologically characterized with drugs relevant for pain treatment, including gabapentin (30 mg/kg and 50 mg/kg), Ica-6p (Kv7." | 3.81 | Development and pharmacological characterization of a model of sleep disruption-induced hypersensitivity in the rat. ( Gilmour, G; Kennedy, JD; Schuh-Hofer, S; Treede, RD; Wafford, KA; Wodarski, R; Yurek, DA, 2015) |
| " Two distinct FAAH inhibitory compounds, URB597 and PF-3845 were tested, and contrasted with standard antinociceptive gabapentin or vehicle treatment, for attenuation of tactile allodynia, cold allodynia, and mechanical hyperalgesia." | 3.81 | Attenuation of persistent pain-related behavior by fatty acid amide hydrolase (FAAH) inhibitors in a rat model of HIV sensory neuropathy. ( Jergova, S; Nasirinezhad, F; Pearson, JP; Sagen, J, 2015) |
| "Experiments were designed to evaluate changes in the histamine release, mast cell number and neuronal damage in hippocampus induced by status epilepticus." | 3.81 | The mast cell stabilizer sodium cromoglycate reduces histamine release and status epilepticus-induced neuronal damage in the rat hippocampus. ( Orozco-Suárez, SA; Rocha, L; Santana-Gómez, CE; Valle-Dorado, MG, 2015) |
| "The serotonin system is intimately linked to both the mediation of anxiety and long-term effects of cocaine, potentially through interaction of inhibitory 5-HT2C receptor and gamma-aminobutyric acid (GABA) networks." | 3.81 | Dorsal raphe 5-HT(2C) receptor and GABA networks regulate anxiety produced by cocaine withdrawal. ( Craige, CP; Kirby, LG; Lewandowski, S; Unterwald, EM, 2015) |
| "Allergic rhinitis was induced in mice by two intra-peritoneal injections of ovalbumin administered with a one-week interval." | 3.81 | Stability of the synaptic structure in the hippocampus of BALB/c mice with allergic rhinitis. ( Jinno, S; Komune, S; Kubo, K; Nariyama, K, 2015) |
| " The maximal electroshock test (MES) and pentylenetertrazole (PTZ)-induced seizures in male mice were used to evaluate anticonvulsant activities of eudesmin, and sedative effects of eudesmin were evaluated by pentobarbital sodium-induced sleeping time (PST) and locomotor activity in mice." | 3.81 | Anticonvulsant and Sedative Effects of Eudesmin isolated from Acorus tatarinowii on mice and rats. ( He, J; Lei, JP; Liao, DG; Liu, F; Liu, H; Luo, K; Song, Z; Yang, L; Zhang, TY; Zhuang, K, 2015) |
| "The aim of the present study was to evaluate the effects of transcranial focal electrical stimulation (TFS) on γ-aminobutyric acid (GABA) and glutamate release in the hippocampus under basal conditions and during pilocarpine-induced status epilepticus (SE)." | 3.81 | Transcranial focal electrical stimulation reduces the convulsive expression and amino acid release in the hippocampus during pilocarpine-induced status epilepticus in rats. ( Alcántara-González, D; Bañuelos-Cabrera, I; Besio, W; Fernández-Mas, R; Luna-Munguía, H; Magdaleno-Madrigal, V; Rocha, L; Santana-Gómez, CE, 2015) |
| "Mechanical allodynia in SNL rats was attenuated by gabapentin (100 mg/kg) and AQU-118 (in a dose-dependent manner)." | 3.81 | Effect of a Novel, Orally Active Matrix Metalloproteinase-2 and -9 Inhibitor in Spinal and Trigeminal Rat Models of Neuropathic Pain. ( Davis, SF; Fairchild, DD; Hain, HS; Hanania, T; Henry, MA; Hu, A; Malekiani, SA; Nix, D; Patil, MJ; Sucholeiki, I; Sucholeiki, R, 2015) |
| "The results demonstrated that oral AQU-118 attenuates mechanical allodynia in both neuropathic pain models and with efficacies that mirror gabapentin at the 40 mg/kg dose used in the CCI-IoN model but without effect on basal sensitivity to mechanical stimulation/locomotive activity." | 3.81 | Effect of a Novel, Orally Active Matrix Metalloproteinase-2 and -9 Inhibitor in Spinal and Trigeminal Rat Models of Neuropathic Pain. ( Davis, SF; Fairchild, DD; Hain, HS; Hanania, T; Henry, MA; Hu, A; Malekiani, SA; Nix, D; Patil, MJ; Sucholeiki, I; Sucholeiki, R, 2015) |
| " In particular, 14 and 15 were found to be more potent than morphine for both acute and inflammatory pain models and 100-fold more potent than gabapentin in a diabetic neuropathic pain model." | 3.81 | Antinociceptive Grayanoids from the Roots of Rhododendron molle. ( Li, Y; Liu, Y; Liu, YB; Lv, HN; Ma, SG; Qu, J; Yu, SS; Zhang, JJ, 2015) |
| "The goal of this study was to use a status epilepticus steady-state chemical model in rats using the convulsant, 3-mercaptopropionic acid (3-MPA), and to compare the changes in striatal neurotransmission on a slow (5min) and fast (60s) timescale." | 3.80 | Correlation of 3-mercaptopropionic acid induced seizures and changes in striatal neurotransmitters monitored by microdialysis. ( Crick, EW; Frei, M; Lunte, CE; Mayer, AP; Osorio, I, 2014) |
| "Synthetic approaches to gabapentin bioconjugates that overcome the tendency of gabapentin to cyclize into its γ-lactam are studied." | 3.80 | Gabapentin hybrid peptides and bioconjugates. ( Alamry, KA; Goncalves, K; Ibrahim, MA; Katritzky, AR; Lebedyeva, IO; Neubert, J; Ostrov, DA; Patel, K; Sileno, SM; Steel, PJ, 2014) |
| "This study investigated the effects of Phα1β, pregabalin and diclofenac using an animal model of fibromyalgia (FM)." | 3.80 | The effects of Phα1β, a spider toxin, calcium channel blocker, in a mouse fibromyalgia model. ( Castro, CJ; da Costa Lopes, AM; da Silva, CA; da Silva, JF; de Souza, AH; Ferreira, J; Gomez, MV; Klein, CP; Pereira, EM, 2014) |
| "We report that the oxytocin-mediated neuroprotective γ-aminobutyric acid (GABA) excitatory-inhibitory shift during delivery is abolished in the valproate and fragile X rodent models of autism." | 3.80 | Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring. ( Ben-Ari, Y; Brouchoud, C; Burnashev, N; Chazal, G; Eftekhari, S; Ferrari, DC; Khalilov, I; Lemonnier, E; Lozovaya, N; Nardou, R; Shahrokhi, A; Tsintsadze, T; Tsintsadze, V; Tyzio, R, 2014) |
| "This study investigated whether the spinal or systemic treatment with the lipid resolution mediators resolvin D1 (RvD1), aspirin-triggered resolvin D1 (AT-RvD1) and resolvin D2 (RvD2) might interfere with behavioral and neurochemical changes in the mouse fibromyalgia-like model induced by reserpine." | 3.80 | Effects of D-series resolvins on behavioral and neurochemical changes in a fibromyalgia-like model in mice. ( Campos, MM; Klein, CP; Leite, CE; Maciel, IS; Souza, AH; Sperotto, ND, 2014) |
| "Although pregabalin has been shown to have preclinical and clinical efficacy in neuropathic pain, the mechanism of its antinociceptive action is still unknown in other pain states." | 3.80 | Inhibition of mitogen-activated protein kinases phosphorylation plays an important role in the anti-nociceptive effect of pregabalin in zymosan-induced inflammatory pain model. ( Jeong, YC; Kwon, YB; Pyun, K, 2014) |
| "Piperine produced significant antianxiety-like activity in unstressed and stressed mice." | 3.80 | Possible involvement of GABAergic and nitriergic systems for antianxiety-like activity of piperine in unstressed and stressed mice. ( Dhingra, D; Gilhotra, N, 2014) |
| "These data indicate that MSCs were superior to gabapentin in ameliorating PTZ-induced epileptogenesis and verified the potential use of MSCs in seizure control, motor and cognitive impairments, oxidative stress, and the impairing GABA level in experimentally induced epilepsy." | 3.80 | Effects of intravenous human umbilical cord blood mesenchymal stem cell therapy versus gabapentin in pentylenetetrazole-induced chronic epilepsy in rats. ( Essawy, SS; Ewais, MM; Mohammed, AS; Tawfik, MK, 2014) |
| "Orofacial capsaicin and formalin tests were employed in male Wistar rats to assess the influence of pregabalin (or vehicle) pretreatment in acute pain models, and the results from these experiments were analyzed by one-way analysis of variance (ANOVA) followed by Newman Keuls post-hoc test." | 3.80 | Pregabalin reduces acute inflammatory and persistent pain associated with nerve injury and cancer in rat models of orofacial pain. ( Chichorro, JG; Hummig, W; Kopruszinski, CM, 2014) |
| "To assess the analgesic effect of pregabalin in orofacial models of acute inflammatory pain and of persistent pain associated with nerve injury and cancer, and so determine its effectiveness in controlling orofacial pains having different underlying mechanisms." | 3.80 | Pregabalin reduces acute inflammatory and persistent pain associated with nerve injury and cancer in rat models of orofacial pain. ( Chichorro, JG; Hummig, W; Kopruszinski, CM, 2014) |
| "Pregabalin produced a marked antinociceptive effect in rat models of facial inflammatory pain as well as in facial neuropathic and cancer pain models, suggesting that it may represent an important agent for the clinical control of orofacial pain." | 3.80 | Pregabalin reduces acute inflammatory and persistent pain associated with nerve injury and cancer in rat models of orofacial pain. ( Chichorro, JG; Hummig, W; Kopruszinski, CM, 2014) |
| " To analyse early processes in epileptogenesis we used the juvenile pilocarpine model to study status epilepticus (SE)-induced changes in expression of key components in the glutamate-glutamine cycle, known to be affected in MTS patients." | 3.80 | Persistent reduction of hippocampal glutamine synthetase expression after status epilepticus in immature rats. ( Bos, IW; de Graan, PN; Hessel, EV; Mulder, SD; van der Hel, WS; van Eijsden, P; Verlinde, SA, 2014) |
| "Latrunculin A microperfusion of the hippocampus induces acute epileptic seizures and long-term biochemical changes leading to spontaneous seizures." | 3.80 | Effects of eslicarbazepine acetate on acute and chronic latrunculin A-induced seizures and extracellular amino acid levels in the mouse hippocampus. ( Loureiro, AI; Sierra-Marcuño, G; Sierra-Paredes, G; Soares-da-Silva, P; Wright, LC, 2014) |
| "Oral administration of ESL (100 mg/kg), previous to latrunculin A microperfusion, completely prevented acute latrunculin A-induced seizures as well as chronic seizures and all EEG chronic signs of paroxysmal activity." | 3.80 | Effects of eslicarbazepine acetate on acute and chronic latrunculin A-induced seizures and extracellular amino acid levels in the mouse hippocampus. ( Loureiro, AI; Sierra-Marcuño, G; Sierra-Paredes, G; Soares-da-Silva, P; Wright, LC, 2014) |
| "ESL treatment prevented acute latrunculin A-induced seizures as well as chronic seizures and all EEG chronic signs of paroxysmal activity, supporting a possible anti-epileptogenic effect of ESL in mice." | 3.80 | Effects of eslicarbazepine acetate on acute and chronic latrunculin A-induced seizures and extracellular amino acid levels in the mouse hippocampus. ( Loureiro, AI; Sierra-Marcuño, G; Sierra-Paredes, G; Soares-da-Silva, P; Wright, LC, 2014) |
| " While seizures are usually intractable to medication in tuberous sclerosis complex (TSC), a common genetic cause of epilepsy, vigabatrin appears to have unique efficacy for epilepsy in TSC." | 3.79 | Vigabatrin inhibits seizures and mTOR pathway activation in a mouse model of tuberous sclerosis complex. ( McDaniel, SS; Rensing, NR; Wong, M; Zhang, B, 2013) |
| "The rostroventromedial medulla (RVM) is an important area of the endogenous pain-regulating system, in which 5-hydroxytryptamine (5-HT) and gamma-aminobutyric acid (GABA) are 2 main transmitters involved in pain modulation." | 3.79 | Neurokinin-1 receptor-expressing neurons that contain serotonin and gamma-aminobutyric acid in the rat rostroventromedial medulla are involved in pain processing. ( Chen, T; Li, YQ; Qu, J; Wang, W; Wang, XL; Wu, SX; Yanagawa, Y; Zhang, T, 2013) |
| " We have shown that perinatal exposure to bisphenol A (BPA) at environmental dose level causes long-term anxiety-like behaviors in rats." | 3.79 | Persistent overexpression of DNA methyltransferase 1 attenuating GABAergic inhibition in basolateral amygdala accounts for anxiety in rat offspring exposed perinatally to low-dose bisphenol A. ( Bai, Y; Chang, F; Chen, F; Chen, L; Zhou, R, 2013) |
| " NKCC1 or KCC2 expression changes have been demonstrated previously in the hippocampal neurons of mice with pilocarpine-induced status epilepticus (PISE)." | 3.79 | STE20/SPS1-related proline/alanine-rich kinase is involved in plasticity of GABA signaling function in a mouse model of acquired epilepsy. ( Cai, X; Chen, S; Chen, Y; Chen, Z; Fang, Z; Wang, Q; Yang, L; Zhou, J; Zhou, L, 2013) |
| " Our data have demonstrated that pentylenetetrazole (PTZ)-induced seizures did not alter ATP, ADP, and AMP hydrolysis in brain membrane fractions." | 3.79 | Antiepileptic drugs prevent changes in adenosine deamination during acute seizure episodes in adult zebrafish. ( Bogo, MR; Bonan, CD; Nery, LR; Piato, AL; Schaefer, IC; Siebel, AM, 2013) |
| " We here investigated for the first time the effect of L-theanine intake on seizure susceptibility using acute pilocarpine and pentylenetetrazol (PTZ) mouse models for studying, respectively, limbic seizures or primarily generalized seizures." | 3.79 | L-Theanine intake increases threshold for limbic seizures but decreases threshold for generalized seizures. ( Loyens, E; Massie, A; Michotte, Y; Schallier, A; Smolders, I; Van Liefferinge, J; Vermoesen, K, 2013) |
| "The aim of this study is to investigate the effects of pregabalin on the behavior of rats under the influence of ketamine, an NMDA receptor antagonist that mimics the symptoms of schizophrenia." | 3.78 | Effects of pregabalin on behavioral alterations induced by ketamine in rats. ( Baker, GB; Canever, L; Crippa, JA; Dursun, SM; Hallak, JE; Luca, RD; Nunes, EA; Oliveira, Ld; Peregrino, A; Quevedo, J; Zugno, A, 2012) |
| "To investigate the anticonvulsant activity of the lobeline isolated from the Lobelia nicotianaefolia in chemoconvulsant-induced seizures and its biochemical mechanism by investigating relationship between seizure activities and altered gamma amino butyric acid (GABA) in brain of mice in Pentylenetetrazol (PTZ) seizure models." | 3.78 | Antiepileptic activity of lobeline isolated from the leaf of Lobelia nicotianaefolia and its effect on brain GABA level in mice. ( Bodhankar, SL; Ghosh, P; Rub, RA; Tamboli, AM, 2012) |
| "In our findings, isolated lobeline (20mg/kg) exhibited potent anticonvulsant activity against PTZ induced seizures." | 3.78 | Antiepileptic activity of lobeline isolated from the leaf of Lobelia nicotianaefolia and its effect on brain GABA level in mice. ( Bodhankar, SL; Ghosh, P; Rub, RA; Tamboli, AM, 2012) |
| "Lysophosphatidic acid (LPA), an initiator of neuropathic pain, causes allodynia." | 3.78 | Pharmacological characterization of lysophosphatidic acid-induced pain with clinically relevant neuropathic pain drugs. ( Kato, A; Ogawa, K; Shinohara, S; Takasu, K; Yoneda, Y, 2012) |
| " We compared the efficacy of orally administered morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia with that on neuroma pain using the tibial neuroma transposition (TNT) model." | 3.78 | The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model. ( Miyazaki, R; Yamamoto, T, 2012) |
| "Morphine, pregabalin, gabapentin, and duloxetine attenuated the level of mechanical allodynia in a dose-dependent manner." | 3.78 | The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model. ( Miyazaki, R; Yamamoto, T, 2012) |
| "These data indicate that the potency of morphine and the efficacy of pregabalin, gabapentin, and duloxetine on mechanical allodynia are different from those on neuroma pain and that combination therapy is one of different therapeutic choices for the treatment of neuropathic pain." | 3.78 | The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model. ( Miyazaki, R; Yamamoto, T, 2012) |
| "The effect of the cyclooxygenase-2 (COX-2) inhibitor etodolac on the mechanical allodynia induced by paclitaxel was investigated in mice and compared with the effects of the nonselective COX inhibitors indomethacin and diclofenac, the selective COX-2 inhibitor celecoxib, the calcium channel α(2)δ subunit inhibitor pregabalin, the sodium channel blocker mexiletine, and the serotonin-norepinephrine reuptake inhibitor duloxetine." | 3.78 | Etodolac, a cyclooxygenase-2 inhibitor, attenuates paclitaxel-induced peripheral neuropathy in a mouse model of mechanical allodynia. ( Banno, K; Inoue, N; Ito, S; Kotera, T; Kyoi, T; Nakamura, A; Nogawa, M; Sasagawa, T; Tajima, K; Takahashi, Y; Ueda, M; Yamashita, Y, 2012) |
| " The von Frey filaments, acetone drop, and radiant heat test were performed to assess the degree of mechanical allodynia, thermal allodynia and thermal hyperalgesia respectively, at different time intervals, i." | 3.78 | Evaluation of aqueous and ethanolic extracts of saffron, Crocus sativus L., and its constituents, safranal and crocin in allodynia and hyperalgesia induced by chronic constriction injury model of neuropathic pain in rats. ( Amin, B; Hosseinzadeh, H, 2012) |
| "Glutaric acidemia type I (GA-I) is an inherited metabolic disease characterized by accumulation of glutaric acid (GA) and seizures." | 3.78 | m-Trifluoromethyl diphenyl diselenide attenuates glutaric acid-induced seizures and oxidative stress in rat pups: involvement of the γ-aminobutyric acidergic system. ( Brüning, CA; Fighera, MR; Gai, BM; Magni, DV; Nogueira, CW; Quines, CB; Rosa, SG, 2012) |
| " A recent study from our laboratory revealed that gabapentin, a recommended first-line treatment for multiple neuropathic conditions, could also efficiently antagonize thermal hyperalgesia evoked by complete Freund's adjuvant (CFA)-induced monoarthritis (MA)." | 3.78 | Gabapentin reduces CX3CL1 signaling and blocks spinal microglial activation in monoarthritic rats. ( Deng, XM; Li, SS; Xu, B; Xu, H; Yang, JL; Zhang, WS; Zhang, YQ, 2012) |
| " We hypothesized that the volatile anesthetic sevoflurane (SEVO) attenuates lung inflammation through activation of lung epithelial GABA(A) receptors." | 3.78 | Effects of anesthetic regimes on inflammatory responses in a rat model of acute lung injury. ( Fortis, S; Haitsma, JJ; Lu, WY; Mazer, CD; Parotto, M; Slutsky, AS; Spieth, PM; Zhang, H; Zhong, N, 2012) |
| "The aim of present study was to investigate the antinociceptive effect of pregabalin and tramadol either alone and or in combination on acute model of pain." | 3.78 | Pregabalin antinociception and its interaction with tramadol in acute model of pain. ( Keyhanfar, F; Meymandi, MS, 2012) |
| "Pregabalin revealed a comparative antinociceptive effect as similar to tramadol in acute model of pain, but interaction between these two drugs depends highly on their proportion in the combination." | 3.78 | Pregabalin antinociception and its interaction with tramadol in acute model of pain. ( Keyhanfar, F; Meymandi, MS, 2012) |
| "The aim of the present study was to investigate the possible antinociceptive effects of systemic administration of tramadol and gabapentin either alone or in combination on acute pain models in mice." | 3.78 | The antinociceptive effects of systemic administration of tramadol, gabapentin and their combination on mice model of acute pain. ( Alaçam, B; Aydin, ON; Ek, RO; Şen, S; Temoçin, S; Uğur, B, 2012) |
| "Epileptiform discharges recorded in the 4-aminopyridine (4-AP) in vitro epilepsy model are mediated by glutamatergic and GABAergic signaling." | 3.77 | The 4-aminopyridine in vitro epilepsy model analyzed with a perforated multi-electrode array. ( Avoli, M; Dzakpasu, R; Gonzalez-Sulser, A; Motamedi, GK; Vicini, S; Wang, J, 2011) |
| "We showed a preventative effect of intrathecal gabapentin on the development of nerve injury-induced mechanical allodynia and thermal hyperalgesia." | 3.77 | Chronic intrathecal infusion of gabapentin prevents nerve ligation-induced pain in rats. ( Chen, CC; Cheng, JK; Chu, LC; Hung, YC; Lin, CS; Tsaur, ML; Wang, TY, 2011) |
| " The anticonvulsant gabapentin, which is widely used as an analgesic agent, also reduces anxiety." | 3.77 | The effects of gabapentin in two animal models of co-morbid anxiety and visceral hypersensitivity. ( Coelho, AM; Cryan, JF; Dinan, TG; Fitzgerald, P; Lee, K; O' Mahony, SM; Winchester, W, 2011) |
| "The present study was focused to characterize the effects of intrahippocampal application of R-verapamil, a P-glycoprotein blocker, and High Frequency Electrical Stimulation (HFS) at 130 Hz, on seizure susceptibility and extracellular concentrations of glutamate and γ-aminobutyric acid (GABA) in hippocampus of kindled rats with drug-resistant seizures." | 3.77 | Effects of high frequency electrical stimulation and R-verapamil on seizure susceptibility and glutamate and GABA release in a model of phenytoin-resistant seizures. ( Luna-Munguia, H; Orozco-Suarez, S; Rocha, L, 2011) |
| "Leptin acts in the brain to prevent obesity." | 3.77 | Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons. ( Choi, B; Chua, S; Lowell, BB; Vong, L; Yang, Z; Ye, C, 2011) |
| " The results indicate that pretreatment with Parawixin 10 prevents the onset of seizures induced with kainic acid, N-methyl-D-aspartate, and pentylenetetrazole in a dose-response manner." | 3.77 | Neurobiological activity of Parawixin 10, a novel anticonvulsant compound isolated from Parawixia bistriata spider venom (Araneidae: Araneae). ( Beleboni, RO; Coutinho-Netto, J; Cunha, AO; dos Santos, WF; Fachim, HA; Gobbo-Neto, L; Lopes, NP; Pereira, AC, 2011) |
| "The aim of the present study was to investigate the role of GABAergic and nitriergic modulation in the antianxiety effect of thymoquinone, a major constituent of Nigella sativa, in mice under unstressed and stressed conditions." | 3.77 | Thymoquinone produced antianxiety-like effects in mice through modulation of GABA and NO levels. ( Dhingra, D; Gilhotra, N, 2011) |
| "The present study was performed to investigate whether or not carvedilol (a beta-adrenoreceptor antagonist) potentiates the anticonvulsive activity of gabapentin against ICES (Increasing current electroshock) and PTZ (Pentylenetetrazole) induced seizures in mice." | 3.77 | Influence of carvedilol on anticonvulsant effect of gabapentin. ( Goel, A; Goel, R; Kumar, Y, 2011) |
| "To evaluate the effects of high-frequency electrical stimulation (HFS) in both ventral hippocampi, alone and combined with a subeffective dose of antiepileptic drugs, during the status epilepticus (SE) induced by lithium-pilocarpine (LP)." | 3.76 | Antiepileptic drugs combined with high-frequency electrical stimulation in the ventral hippocampus modify pilocarpine-induced status epilepticus in rats. ( Alcantara-Gonzalez, D; Cuellar-Herrera, M; Neri-Bazan, L; Peña, F; Rocha, L, 2010) |
| " The present study evaluated the distribution pattern of GABAergic interneurons, especially parvalbumin (PV)- and somatostatin (SS)-immunopositive neurons, and excitatory propagation pattern in the IC of rats 4-7 days and 2 months after pilocarpine-induced status epilepticus (4-7 d and 2 m post-SE rats, respectively)." | 3.76 | Pilocarpine-induced status epilepticus causes acute interneuron loss and hyper-excitatory propagation in rat insular cortex. ( Chen, S; Fujita, S; Kobayashi, M; Koshikawa, N, 2010) |
| " Stereological techniques were used to estimate numbers of gephyrin-positive punctae in the dentate gyrus, which were reduced short-term (5 days after pilocarpine-induced status epilepticus) but later rebounded beyond controls in epileptic rats." | 3.76 | Initial loss but later excess of GABAergic synapses with dentate granule cells in a rat model of temporal lobe epilepsy. ( Buckmaster, PS; Phanwar, I; Thind, KK; Wen, X; Yamawaki, R; Zhang, G, 2010) |
| " The present study optimized the method to induce differentiation of gamma-aminobutyric acid-producing neurons (GABAergic neurons) from ES cell-derived neural stem/progenitor cells (NS/PCs), and transplanted these ES cell-derived GABAergic neurons producing neural progenitors into kindled epileptic mice, and analyzed the morphological and functional recovery from epilepsy." | 3.76 | Seizure suppression in amygdala-kindled mice by transplantation of neural stem/progenitor cells derived from mouse embryonic stem cells. ( Itano, T; Kawai, N; Matsumoto, Y; Nagao, S; Nakamura, T; Okano, H; Shindo, A; Tamiya, T, 2010) |
| " We have previously shown that postnatal administration of low doses of domoic acid (DOM) can produce many of the behavioral and morphological changes found in current animal models of temporal lobe epilepsy (TLE), as well as the human condition." | 3.76 | Selective reductions in subpopulations of GABAergic neurons in a developmental rat model of epilepsy. ( Gill, DA; Ramsay, SL; Tasker, RA, 2010) |
| "Gabapentin, an anticonvulsant, is widely accepted as an alternative therapeutic agent for neuropathic pain and has proved to produce analgesic effects in a mouse model of visceral pain." | 3.76 | Analgesic effects of gabapentin on mechanical hypersensitivity in a rat model of chronic pancreatitis. ( Chen, H; Liao, XZ; Mao, YF; Sun, JH; Xiong, YC; Xu, H; Zhou, MT, 2010) |
| "Pre-treatment with GABA (40 mg/kg), diazepam, phenobarbital, AOAA and DABA abolished the appearance of seizures induced by 50 mg/kg (PhSe)₂ in rat pups." | 3.76 | Diphenyl diselenide-induced seizures in rat pups: possible interaction with GABAergic system. ( Nogueira, CW; Prigol, M; Wilhelm, EA; Zeni, G, 2010) |
| "The inhibitory transmitters GABA and glycine play an important role in modulating pain transmission, both in normal and in pathological situations." | 3.76 | Differential distribution of activated spinal neurons containing glycine and/or GABA and expressing c-fos in acute and chronic pain models. ( Duraku, LS; Holstege, JC; Hossaini, M; Jongen, JLM; Saraç, Ç, 2010) |
| " A major debilitating phenotype in affected females is frequent apneas, and heterozygous Mecp2-deficient female mice mimic the human respiratory disorder." | 3.76 | Correction of respiratory disorders in a mouse model of Rett syndrome. ( Abdala, AP; Bissonnette, JM; Dutschmann, M; Paton, JF, 2010) |
| "To characterize the interactions between levetiracetam and the antiepileptic drugs gabapentin, tiagabine, and vigabatrin in suppressing pentylenetetrazole-induced clonic seizures in mice, type II isobolographic analysis was used." | 3.75 | Pharmacodynamic and pharmacokinetic interaction profiles of levetiracetam in combination with gabapentin, tiagabine and vigabatrin in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis. ( Andres-Mach, MM; Czuczwar, SJ; Dudra-Jastrzebska, M; Luszczki, JJ; Patsalos, PN; Ratnaraj, N; Sielski, M, 2009) |
| " In Wernicke-Korsakoff's syndrome (WKS) and the animal model of the disorder, pyrithiamine-induced thiamine deficiency (PTD), there is both diencephalic damage and basal forebrain cell loss that could contribute to the amnesic state." | 3.75 | The role of cholinergic and GABAergic medial septal/diagonal band cell populations in the emergence of diencephalic amnesia. ( Roland, JJ; Savage, LM, 2009) |
| "Our data suggest that activation of spinal or dorsal root ganglion HCN channels or both is not involved in formalin-induced pain, and intrathecal gabapentin does not act as an HCN channel activator to achieve its antinociceptive effect in the formalin test." | 3.75 | Intrathecal gabapentin does not act as a hyperpolarization-activated cyclic nucleotide-gated channel activator in the rat formalin test. ( Chen, CC; Cheng, JK; Huang, YJ; Lin, CF; Lin, CS; Tsaur, ML, 2009) |
| " Here we have tested if this hypothesis applies to other pain states by using a combination of approaches in a rat model of osteoarthritis (OA) to ascertain if 1) a role for descending 5HT mediated facilitation exists, and 2) if pregabalin (a newer analogue of gabapentin) is an effective antinociceptive agent in this model." | 3.75 | Descending serotonergic facilitation and the antinociceptive effects of pregabalin in a rat model of osteoarthritic pain. ( Bannister, K; Bauer, CS; Dickenson, AH; Dolphin, AC; Rahman, W; Vonsy, JL, 2009) |
| "Evidence suggests an important role for supraspinal gamma-aminobutyric acid (GABA) in conditioned fear and pain." | 3.75 | Alterations in extracellular levels of gamma-aminobutyric acid in the rat basolateral amygdala and periaqueductal gray during conditioned fear, persistent pain and fear-conditioned analgesia. ( Finn, DP; Lang, Y; Rea, K, 2009) |
| "In the short term, doses of 100 mg/kg and 300 mg/kg of pregabalin effectively attenuated anxiety-like behaviors." | 3.74 | Brief post-stressor treatment with pregabalin in an animal model for PTSD: short-term anxiolytic effects without long-term anxiogenic effect. ( Cohen, H; Ifergane, G; Kaplan, Z; Matar, MA; Zohar, J, 2008) |
| "The effect of hyperhomocysteinemia induced by pretreatment with methionine 12 weeks prior to the study on the responses induced by gamma-aminobutyric acid (GABA), electrical field stimulation (EFS), and ATP have been evaluated in isolated rat duodenum." | 3.74 | Effects of hyperhomocysteinemia on non-adrenergic non-cholinergic relaxation in isolated rat duodenum. ( Karasu, E; Sadan, G; Tasatargil, A, 2008) |
| "Pregabalin, which binds to the alpha2-delta subunit of voltage-gated calcium channels, increased the threshold for pain during colorectal distension (CRD) in irritable bowel syndrome (IBS) patients." | 3.74 | Effects of pregabalin on visceral pain responses and colonic compliance in rats. ( Brusberg, M; Larsson, H; Lindström, E; Martínez, V; Ravnefjord, A, 2008) |
| " Isobolographic analysis was used in two mouse experimental models of epilepsy: the maximal electroshock seizure threshold test and pentylenetetrazole-induced seizures." | 3.74 | Isobolographic and behavioral characterizations of interactions between vigabatrin and gabapentin in two experimental models of epilepsy. ( Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N, 2008) |
| "To observe the effects of gamma-aminobutyric acid (GABA) on the electric activities of pain-excited neurons (PEN) in nucleus accumbens (NAc) in central nervous system (CNS) of morphine-dependent rats." | 3.74 | Modulation of gamma-aminobutyric acid on painful sense in central nervous system of morphine-dependent rats. ( Li, X; Xu, MY; Xu, Y, 2008) |
| "After GABA or the GABA(A)-receptor antagonist, bicuculline (Bic), was injected into cerebral ventricles or NAc, right sciatic nerve was stimulated by electrical pulses, which was considered as traumatic pain stimulation." | 3.74 | Modulation of gamma-aminobutyric acid on painful sense in central nervous system of morphine-dependent rats. ( Li, X; Xu, MY; Xu, Y, 2008) |
| "The effects of treatment with the anti-convulsant agents, lamotrigine and riluzole were compared with gabapentin in a rat experimental model of neuropathic pain." | 3.74 | A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain. ( Coderre, TJ; Kumar, N; Lefebvre, CD; Yu, JS, 2007) |
| "Pregabalin is used for treatment of neuropathic pain conditions." | 3.74 | Pregabalin reduces muscle and cutaneous hyperalgesia in two models of chronic muscle pain in rats. ( Audette, KM; Maeda, Y; Sluka, KA; Yokoyama, T, 2007) |
| "This study shows that pregabalin reduces both cutaneous and muscle hyperalgesia in inflammatory and noninflammatory models of muscle pain." | 3.74 | Pregabalin reduces muscle and cutaneous hyperalgesia in two models of chronic muscle pain in rats. ( Audette, KM; Maeda, Y; Sluka, KA; Yokoyama, T, 2007) |
| "Acute administration of the psychotomimetic phencyclidine (PCP) can mimic some features of schizophrenia, while a repeated treatment regimen of PCP may provide a more effective way to model in animals the enduring cognitive dysfunction observed in many schizophrenic patients." | 3.74 | Sub-chronic psychotomimetic phencyclidine induces deficits in reversal learning and alterations in parvalbumin-immunoreactive expression in the rat. ( Abdul-Monim, Z; Neill, JC; Reynolds, GP, 2007) |
| "Neurodevelopmental deficits of parvalbumin-immunoreactive gamma-aminobutyric acid (GABA)ergic interneurons in prefrontal cortex have been reported in schizophrenia." | 3.74 | Prenatal exposure to an NMDA receptor antagonist, MK-801 reduces density of parvalbumin-immunoreactive GABAergic neurons in the medial prefrontal cortex and enhances phencyclidine-induced hyperlocomotion but not behavioral sensitization to methamphetamine ( Abekawa, T; Ito, K; Koyama, T; Nakagawa, S, 2007) |
| "We investigated efficacy of prolonged intraventricular gabapentin (GBP) infusion in the rat flurothyl epilepsy model." | 3.74 | Intraventricular administration of gabapentin in the rat increases flurothyl seizure threshold. ( Fisher, RS; Kraus, AC; Oommen, J, 2007) |
| " After 5 days of GBP infusion, seizures were induced by flurothyl dripped onto filter paper." | 3.74 | Intraventricular administration of gabapentin in the rat increases flurothyl seizure threshold. ( Fisher, RS; Kraus, AC; Oommen, J, 2007) |
| "GBP instilled into the lateral ventricles by pump for 5 days delays onset of generalized tonic-clonic seizures produced by flurothyl in the rat." | 3.74 | Intraventricular administration of gabapentin in the rat increases flurothyl seizure threshold. ( Fisher, RS; Kraus, AC; Oommen, J, 2007) |
| "There is an accumulation of evidence for abnormalities in schizophrenia of both the major neurotransmitter systems of the brain - those of GABA (gamma-aminobutyric acid) and glutamate." | 3.74 | The neuronal pathology of schizophrenia: molecules and mechanisms. ( Harte, MK; Reynolds, GP, 2007) |
| " As part of a systematic effort to identify the optimal compounds and protocols for such a therapy, this study aimed to determine whether transmeningeal gamma-aminobutyric acid (GABA) delivery can terminate and/or prevent neocortical seizures in rats." | 3.74 | Transmeningeal delivery of GABA to control neocortical seizures in rats. ( Baptiste, SL; Devinsky, O; John, JE; Kuzniecky, RI; Ludvig, N; Sheffield, LG; von Gizycki, H, 2007) |
| "Chronic lamotrigine, which is effective in the depressive phase or rapid cycling bipolar disorder does not alter brain arachidonic acid turnover in the unanesthetized rat." | 3.74 | Chronic lamotrigine does not alter the turnover of arachidonic acid within brain phospholipids of the unanesthetized rat: implications for the treatment of bipolar disorder. ( Bazinet, RP; Chang, L; Lee, HJ; Rao, JS; Rapoport, SI, 2007) |
| "Drugs that are effective in treating the manic phase of bipolar disorder (lithium, carbamazepine, and valproate) upon chronic administration to rats decrease the turnover of arachidonic acid in their brain phospholipids." | 3.74 | Chronic lamotrigine does not alter the turnover of arachidonic acid within brain phospholipids of the unanesthetized rat: implications for the treatment of bipolar disorder. ( Bazinet, RP; Chang, L; Lee, HJ; Rao, JS; Rapoport, SI, 2007) |
| "Activation of the laryngeal mucosa results in apnea that is mediated through, and can be elicited via electrical stimulation of, the superior laryngeal nerve (SLN)." | 3.74 | Activation of central adenosine A(2A) receptors enhances superior laryngeal nerve stimulation-induced apnea in piglets via a GABAergic pathway. ( Abu-Shaweesh, JM, 2007) |
| "These data demonstrated the comparable efficacy of gabapentin with morphine in visceral pain." | 3.74 | Gabapentin action and interaction on the antinociceptive effect of morphine on visceral pain in mice. ( Meymandi, MS; Sepehri, G, 2008) |
| " The three models were benchmarked using compounds known to be active in neuropathic pain patients and nerve injury animal models, including gabapentin, amitriptyline and clonidine." | 3.74 | Transient allodynia pain models in mice for early assessment of analgesic activity. ( Cheevers, CV; Donello, JE; Gil, DW, 2008) |
| "A comparison of total body doses that cause allodynia following spinal or systemic administration indicated that NMDA induces allodynia in the spinal cord while sulprostone and phenylephrine act through a peripheral mechanism." | 3.74 | Transient allodynia pain models in mice for early assessment of analgesic activity. ( Cheevers, CV; Donello, JE; Gil, DW, 2008) |
| "The theory of depression is dominated by the monoamine hypothesis but there is increasing evidence that beyond monoamines, glutamate (Glu) and gamma-aminobutyric acid (GABA) play an essential role in the pathogenesis of depression." | 3.74 | Elevated spectroscopic glutamate/gamma-amino butyric acid in rats bred for learned helplessness. ( Ende, G; Henn, FA; Mahlstedt, MM; Sartorius, A; Vollmayr, B, 2007) |
| "The ventilatory response to hypoxia is influenced by the balance between inhibitory (GABA, glycine, and taurine) and excitatory (glutamate and aspartate) brainstem amino acid (AA) neurotransmitters." | 3.74 | Brainstem amino acid neurotransmitters and ventilatory response to hypoxia in piglets. ( Bancalari, E; Devia, CJ; Hehre, DA; Suguihara, C, 2008) |
| "Gabapentin (GBP; 1-(aminomethyl)cyclohexane acetic acid) is used clinically in the treatment of pain." | 3.74 | Gabapentin evoked changes in functional activity in nociceptive regions in the brain of the anaesthetized rat: an fMRI study. ( Chapman, V; Governo, RJ; Marsden, CA; Morris, PG, 2008) |
| "We have previously demonstrated that modulation of gamma-aminobutyric acid (GABA) inhibitory tone in the ventromedial hypothalamus (VMH), an important glucose-sensing region in the brain, modulates the magnitude of glucagon and sympathoadrenal responses to hypoglycemia." | 3.74 | Increased GABAergic tone in the ventromedial hypothalamus contributes to suppression of counterregulatory responses after antecedent hypoglycemia. ( Chan, O; Cheng, H; Czyzyk, D; Herzog, R; McCrimmon, RJ; Seashore, MR; Sherwin, RS; Wang, A; Zhu, W, 2008) |
| "There is evidence supporting the antinociceptive effects of carbamazepine, oxcarbazepine, gabapentin, and topiramate in various models of neuropathic pain as well as inflammatory somatic pain." | 3.74 | The antinociceptive effects of anticonvulsants in a mouse visceral pain model. ( Boskovic, B; Milovanovic, S; Paranos, S; Prostran, MS; Stepanovic-Petrovic, RM; Tomic, MA; Ugresic, ND; Vuckovic, SM, 2008) |
| "To examine the in vivo effects of PD-0200347, an alpha(2)delta ligand of voltage-activated Ca(2+) channels and a compound chemically related to pregabalin and gabapentin, on the development of cartilage structural changes in an experimental dog model of osteoarthritis (OA)." | 3.73 | Oral treatment with PD-0200347, an alpha2delta ligand, reduces the development of experimental osteoarthritis by inhibiting metalloproteinases and inducible nitric oxide synthase gene expression and synthesis in cartilage chondrocytes. ( Boileau, C; Boily, M; Brunet, J; El-Kattan, A; Flory, C; Martel-Pelletier, J; Pelletier, JP; Schrier, D; Tardif, G, 2005) |
| "The anticonvulsant gabapentin (GBP) has been shown effective for the treatment of neuropathic pain, although its mechanism of action remains unclear." | 3.73 | Comparison of the antinociceptive profiles of gabapentin and 3-methylgabapentin in rat models of acute and persistent pain: implications for mechanism of action. ( Aiyar, J; Anker, N; Belley, M; Bristow, L; Campbell, B; Cohen, C; Park, KT; Ren, K; Stearns, B; Urban, MO, 2005) |
| "5 hours later by administration of saline vehicle or a regimen of bicuculline (1 mg/kg, sc), a GABA(A) receptor antagonist, which does not produce any intrinsic effects on seizures." | 3.73 | Actions at GABA(A) receptors in the hippocampus may mediate some antiseizure effects of progestins. ( Frye, CA; Rhodes, ME, 2005) |
| " Here, we show that in the spinal sensory circuit progesterone conversion into 5alpha-DHP and 3alpha,5alpha-THP is inhibited dose-dependently by substance P (SP), a major mediator of painful signals." | 3.73 | Substance P inhibits progesterone conversion to neuroactive metabolites in spinal sensory circuit: a potential component of nociception. ( Kibaly, C; Mensah-Nyagan, AG; Patte-Mensah, C, 2005) |
| "Amacrine cells identified by GABA and glycine labeling were not significantly affected by experimental glaucoma, with a mean decrease of 15% compared with bilaterally untreated control cells (557 +/- 186 neurons/mm [glaucoma] versus 653." | 3.73 | The effect of experimental glaucoma and optic nerve transection on amacrine cells in the rat retina. ( Kielczewski, JL; Pease, ME; Quigley, HA, 2005) |
| "The 5-HT re-uptake inhibitor fluoxetine (3-30 mg/kg), the NA re-uptake inhibitor reboxetine (3-30 mg/kg), the dual 5-HT and NA re-uptake inhibitor venlafaxine (3-100 mg/kg) and the dual DA and NA re-uptake inhibitor bupropion (3-30 mg/kg) were tested after intraperitoneal administration in rat models of acute, persistent and neuropathic pain." | 3.73 | Anti-nociception is selectively enhanced by parallel inhibition of multiple subtypes of monoamine transporters in rat models of persistent and neuropathic pain. ( Blackburn-Munro, G; Nielsen, AN; Pedersen, LH, 2005) |
| " Anticonvulsant and acute neurotoxic adverse effect profiles of combinations of GBP and TGB with other AEDs at fixed ratios of 1:3, 1:1 and 3:1 were investigated in pentylenetetrazole (PTZ)-induced seizures and the chimney test (as a measure of motor impairment) in mice so as to identify optimal combinations." | 3.73 | Isobolographic characterisation of interactions among selected newer antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model. ( Czuczwar, SJ; Luszczki, JJ, 2005) |
| "Not all neuropathic pain patients gain relief from current therapies that include the anticonvulsant, gabapentin, thought to modulate calcium channel function." | 3.73 | Spinal-supraspinal serotonergic circuits regulating neuropathic pain and its treatment with gabapentin. ( Dickenson, AH; Hunt, SP; Rahman, W; Rygh, LJ; Suzuki, R; Webber, M, 2005) |
| " The effects of diacerhein were compared with those of gabapentin, a drug used clinically for the management of neuropathic pain." | 3.73 | The effects of diacerhein on mechanical allodynia in inflammatory and neuropathic models of nociception in mice. ( Calixto, JB; Campos, MM; Medeiros, R; Quintão, NLM; Santos, ARS, 2005) |
| " Pilocarpine-induced status epilepticus (SE) was chosen as a model to generate chronic epileptic animals." | 3.73 | Septal GABAergic neurons are selectively vulnerable to pilocarpine-induced status epilepticus and chronic spontaneous seizures. ( Banuelos, C; Castañeda, MT; Colom, LV; Garrido Sanabria, ER; Hernandez, S; Perez-Cordova, MG, 2006) |
| " In this study the co-administration of gabapentin with morphine is evaluated in acute model of pain." | 3.73 | Gabapentin enhances the analgesic response to morphine in acute model of pain in male rats. ( Meymandi, MS; Mobasher, M; Sepehri, G, 2006) |
| "Limbic seizures were evoked in freely moving rats by intrahippocampal administration of pilocarpine via a microdialysis probe." | 3.73 | Substantia nigra is an anticonvulsant site of action of topiramate in the focal pilocarpine model of limbic seizures. ( Clinckers, R; Ebinger, G; Meurs, A; Michotte, Y; Smolders, I, 2006) |
| "Systemic and intranigral, but not intrahippocampal TPM administration suppressed pilocarpine-induced seizures and neurochemical changes." | 3.73 | Substantia nigra is an anticonvulsant site of action of topiramate in the focal pilocarpine model of limbic seizures. ( Clinckers, R; Ebinger, G; Meurs, A; Michotte, Y; Smolders, I, 2006) |
| " Heterozygous ADNFLE mutant mice show persistent, abnormal cortical electroencephalograms with prominent delta and theta frequencies, exhibit frequent spontaneous seizures, and show an increased sensitivity to the proconvulsant action of nicotine." | 3.73 | Seizures and enhanced cortical GABAergic inhibition in two mouse models of human autosomal dominant nocturnal frontal lobe epilepsy. ( Boulter, J; Glykys, J; Klaassen, A; Labarca, C; Maguire, J; Mody, I, 2006) |
| "The release of [(3)H]D-aspartate ([(3)H]D-ASP) or [(3)H]GABA evoked by glycine from spinal cord synaptosomes was compared in mice expressing mutant human SOD1 with a Gly(93) Ala substitution ([SOD1-G93A(+)]), a transgenic model of amyotrophic lateral sclerosis, and in control mice." | 3.72 | Activation of a glycine transporter on spinal cord neurons causes enhanced glutamate release in a mouse model of amyotrophic lateral sclerosis. ( Bonanno, G; Paolucci, E; Prisco, S; Raiteri, L; Raiteri, M, 2003) |
| " Anticonvulsant effects were evaluated against seizures induced by 14 mg kg(-1) of 4-aminopyridine (4-AP) and by 110 mg kg(-1) of pentylenetetrazole (PTZ), and neurotoxicity by the rotarod test." | 3.72 | Is the interaction between felbamate and valproate against seizures induced by 4-aminopyridine and pentylenetetrazole in mice beneficial? ( Amat, G; Armijo, JA; Cuadrado, A, 2003) |
| "The neonatal ventral hippocampal lesion in the rat has been used as a model of schizophrenia, a human disorder associated with changes in markers of dopamine and gamma-aminobutyric acid (GABA) circuits in various regions of the brain." | 3.72 | The neonatal ventral hippocampal lesion model of schizophrenia: effects on dopamine and GABA mRNA markers in the rat midbrain. ( Khaing, ZZ; Lerman, DN; Lipska, BK; Weinberger, DR, 2003) |
| " Intrahippocampal mGluR group I agonist perfusion via a microdialysis probe [1 mm (R,S)-3,5-dihydroxyphenylglycine] induced seizures and concomitant augmentations in amino acid dialysate levels." | 3.72 | In vivo modulation of extracellular hippocampal glutamate and GABA levels and limbic seizures by group I and II metabotropic glutamate receptor ligands. ( Clinckers, R; Ebinger, G; Lindekens, H; Lodge, D; Meurs, A; Michotte, Y; O'Neill, MJ; Smolders, I, 2004) |
| "A series of mutual prodrugs derived from gabapentin, pregabalin, memantine, venlafaxine were synthesized and their pharmacological properties to treat neuropathic pain were investigated in a rat model of chronic sciatic nerve constriction injury (CCI)." | 3.72 | Effect of gabapentin derivates on mechanical allodynia-like behaviour in a rat model of chronic sciatic constriction injury. ( Bo-Hua, Z; He, L; Hong-Ju, Y; Jun-Wei, W; Nan, Z; Wei-Guo, S; Wei-Xiu, Y; Zhe-Hui, G; Zheng-Hua, G; Zhi-Pu, L; Zhong-Wei, J, 2004) |
| "The present study investigated whether mechanical allodynia following contusive spinal cord injury (SCI) of the thoracic segments 12 and 13 of the rat was associated with a reduction in gamma-aminobutyric acid (GABA)ergic inhibition adjacent to the site of injury." | 3.72 | Mechanical allodynia following contusion injury of the rat spinal cord is associated with loss of GABAergic inhibition in the dorsal horn. ( Drew, GM; Duggan, AW; Siddall, PJ, 2004) |
| "Cefoselis is a widely used beta-lactam antibiotic, but occasionally induces seizures and convulsion in elder and renal failure patients." | 3.72 | Cefoselis, a beta-lactam antibiotic, easily penetrates the blood-brain barrier and causes seizure independently by glutamate release. ( Awaya, T; Chiba, K; Fujimaru, S; Hayase, N; Matsubara, K; Ohtaki, K; Shimizu, K; Shiono, H; Suno, M, 2004) |
| " In this study, we investigated the kinetics of glutamate (GLU) and gamma-aminobutyric acid (GABA) in cerebrospinal fluid (CSF-GLU and CSF-GABA, respectively) using a high performance liquid chromatography (HPLC) in a canine model of complex partial status epilepticus (CPSE) induced by the microinjection of kainic acid (KA) into the unilateral amygdala." | 3.72 | Kinetics of glutamate and gamma-aminobutyric acid in cerebrospinal fluid in a canine model of complex partial status epilepticus induced by kainic acid. ( Fujita, M; Hasegawa, D; Matsuki, N; Ono, K; Orima, H, 2004) |
| "To clarify molecular substrates involved in the development of radicular pain, and to investigate the responsiveness of radicular pain to gabapentin." | 3.71 | Changes in expression of voltage-dependent ion channel subunits in dorsal root ganglia of rats with radicular injury and pain. ( Abe, M; Han, W; Kurihara, T; Shinomiya, K; Tanabe, T, 2002) |
| "Microinjections of glutamic acid, serotonin, and sulpiride in the ventromedial hypothalamus reduced anxiety in an illuminated platform avoidance task in rats, while dopamine, apomorphine, picrotoxin, and memantine increased it." | 3.71 | The role of neurochemical mechanisms of ventromedial hypothalamus in various models of anxiety in rats. ( Gordienko, DV; Krivobok, GK; Pankrat'ev, DV; Talalaenko, AN; Zinkovich, II, 2001) |
| "The effects of the gamma-aminobutyric acid (GABA)-potentiating drug gabapentin (1-(aminomethyl) cyclohexaneacetic acid) on severity of dystonia were examined in a hamster model of idiopathic paroxysmal dystonic choreoathetosis." | 3.70 | Gabapentin decreases the severity of dystonia at low doses in a genetic animal model of paroxysmal dystonic choreoathetosis. ( Löscher, W; Richter, A, 1999) |
| "The involvement of phospholipases in ischemia-evoked release of aspartate, glutamate, glycine, and GABA from the cerebral cortex was studied in a four vessel occlusion rat model of cerebral ischemia/reperfusion." | 3.69 | A possible role for phospholipases in the release of neurotransmitter amino acids from ischemic rat cerebral cortex. ( O'Regan, MH; Perkins, LM; Phillis, JW; Smith-Barbour, M, 1995) |
| "The effects of muscimol, amino-oxyacetic acid (AOAA), diamino-N-butyric acid (DABA), bicuculline, picrotoxin, diazepam and phenobarbitone on the protective effect of clonidine against pentylenetetrazol-induced seizures were studied in mice." | 3.69 | gamma Aminobutyric acid mediation of the anticonvulsant effect of clonidine on pentylenetetrazol-induced seizures in mice. ( Amabeoku, G; Bwakura, E; Chikuni, O, 1994) |
| "In order to determine whether changes in synaptic inhibition are involved in chronic models of epilepsy, it is necessary to understand the factors which determine the kinetics of fast gamma-aminobutyric acid (GABA)ergic inhibition." | 3.69 | Analysis of the kinetics of synaptic inhibition points to a reduction in GABA release in area CA1 of the genetically epileptic mouse, El. ( Andreasen, M; Fueta, Y; Lambert, JD; Roepstorff, A, 1996) |
| "Several similarities exist between the alterations observed in the chronic pilocarpine model of recurrent seizures in the rat and those found in human temporal lobe epilepsy." | 3.69 | Vulnerability and plasticity of the GABA system in the pilocarpine model of spontaneous recurrent seizures. ( Esclapez, M; Houser, CR, 1996) |
| "The novel anti-epileptic drugs lamotrigine, felbamate and gabapentin were compared in rat experimental models of acute (tail flick) and chronic pain: the chronic constriction injury and spinal nerve ligation models." | 3.69 | The effect of novel anti-epileptic drugs in rat experimental models of acute and chronic pain. ( Fontana, DJ; Gogas, KR; Hedley, LR; Hunter, JC; Jacobson, LO; Kassotakis, L; Thompson, J, 1997) |
| "Experimental studies indicate that the effects of spinal cord stimulation (SCS) on 'hypersymptoms' in neuropathic pain conditions may at least partly be mediated via GABAergic and adenosine-dependent mechanisms." | 3.69 | Modulation of spinal pain mechanisms by spinal cord stimulation and the potential role of adjuvant pharmacotherapy. ( Cui, JG; Linderoth, B; Meyerson, BA; O'Connor, WT; Segerdahl, M; Sollevi, A; Stiller, CO; Yakhnitsa, V, 1997) |
| "65 g/100 g per os) reduced the incidence and severity of experimental duodenal ulcer induced by cysteamine HCl, and duodenal ulcer induced by cysteamine-HCl plus GABA." | 3.68 | Effects of compound U74500A in animal models of gastric and duodenal ulceration. ( Harding, RK; Krantis, A; McKay, AE; Morris, GP, 1993) |
| " Catecholamines, to a lesser extent the indolamine, serotonin, and the inhibitory transmitter gamma-aminobutyric acid all alter seizures as do less well understood intrinsic hormones and pentapeptides." | 3.67 | Evidence for neurotransmitter abnormalities related to seizure activity in the epileptic baboon. ( Killam, EK; Killam, KF, 1984) |
| "The effect of maternal alcohol consumption during pregnancy and lactation on gamma-aminobutyric acid (GABA) levels in different rat brain regions of 3-week-old pups was investigated." | 3.67 | Effect of pre- and postnatal alcohol consumption on GABA levels of various brain regions in the rat offspring. ( Ciesielski, L; Ledig, M; Lorentz, JG; Mandel, P; Simler, S, 1988) |
| "The anticonvulsant efficacy of the GABAmimetic drugs cetyl GABA, progabide and THIP (4,5,6,7-tetrahydroisoxazolo [5,4-c] pyridine-3-ol) was studied against minor (myoclonic) and major (generalized tonic-clonic) seizures in gerbils as well as against maximal electroshock and s." | 3.67 | Anticonvulsant action of GABA agonists and prodrugs on minor and major seizures in epileptic gerbils. Comparison with mouse models of seizure states. ( Löscher, W, 1985) |
| "In a proposed rat model for anxiety (electrical stimulation of the periaqueductal grey region), progabide (a GABA agonist) and diazepam both increased the latency to escape to a safe compartment and also the current needed to induce the escape response (escape threshold)." | 3.66 | Enhancing GABAergic transmission reverses the aversive state in rats induced by electrical stimulation of the periaqueductal grey region. ( Bovier, P; Broekkamp, CL; Lloyd, KG, 1982) |
| " The neosynthesis of this amino acid from glucose was also studied in two experimental models of hepatic encephalopathy: (1) rats receiving large amounts of ammonium acetate (i." | 3.66 | The release and neosynthesis of glutamic acid are increased in experimental models of hepatic encephalopathy. ( Cortesini, C; Lombardi, G; Moneti, G; Moroni, F, 1983) |
| " It is now reported that membrane preparations from rats with mild galactosamine-induced hepatic encephalopathy show an increase in the number of low- and high-affinity gamma-aminobutyric acid binding sites, whereas those from rats with severe encephalopathy show only high-affinity binding sites." | 3.66 | Experimental hepatic encephalopathy: changes in the binding of gamma-aminobutyric acid. ( Baraldi, M; Zeneroli, ZL, 1982) |
| "Seven GABAmimetic drugs, namely cetyl gamma-aminobutyric acid (cetyl GABA), 4,5,6,7-tetrahydroisoxazolo [5,4-c]pyridine-3-ol, progabide, aminooxyacetic acid, alpha-acetylenic GABA, (-)-nipecotic acid ethyl ester and (+/-)-cis-4-hydroxynipecotic acid methyl ester, were tested for their potency to block "major" (generalized clonic-tonic) seizures in gerbils, induced by blowing at the animals with compressed air." | 3.66 | High anticonvulsant potency of gamma-aminobutyric acid (GABA)mimetic drugs in gerbils with genetically determined epilepsy. ( Frey, HH; Löscher, W; Reiche, R; Schultz, D, 1983) |
| "Gabapentin was administered orally and intracerebroventricularly to rats on the day after paw incision, and withdrawal threshold to paw pressure was measured." | 2.73 | Gabapentin activates spinal noradrenergic activity in rats and humans and reduces hypersensitivity after surgery. ( Curry, R; DeGoes, S; Eisenach, JC; Hayashida, K, 2007) |
| "Gabapentin has been reported to inhibit various acute and chronic pain conditions in animals and humans." | 2.73 | Gabapentin activates spinal noradrenergic activity in rats and humans and reduces hypersensitivity after surgery. ( Curry, R; DeGoes, S; Eisenach, JC; Hayashida, K, 2007) |
| "Progabide was devoid of any evident antipsychotic action." | 2.65 | The potential use of GABA agonists in psychiatric disorders: evidence from studies with progabide in animal models and clinical trials. ( Bartholini, G; Broekkamp, C; Depoortere, H; Fournier, V; Lloyd, KG; Morselli, PL; Scatton, B; Worms, P; Zivkovic, B, 1983) |
| "The analgesic effect in neuropathic pain is well evidenced but the role in postoperative pain is less certain." | 2.58 | Analgesic mechanisms of gabapentinoids and effects in experimental pain models: a narrative review. ( Chincholkar, M, 2018) |
| " Rodent models of CIPN have been developed using a range of dosing regimens to reproduce pain-like behaviours akin to patient-reported symptoms." | 2.53 | Chemotherapy-induced painful neuropathy: pain-like behaviours in rodent models and their response to commonly used analgesics. ( Duggett, NA; Flatters, SJL; Hopkins, HL, 2016) |
| " We present an overview of dosing regimens to produce CIPN models and their phenotype of pain-like behaviours." | 2.53 | Chemotherapy-induced painful neuropathy: pain-like behaviours in rodent models and their response to commonly used analgesics. ( Duggett, NA; Flatters, SJL; Hopkins, HL, 2016) |
| "The review outlines the latest description of the most-relevant rodent models of CIPN enabling comparison between chemotherapeutics, dosing regimen, rodent strain, and sex." | 2.53 | Chemotherapy-induced painful neuropathy: pain-like behaviours in rodent models and their response to commonly used analgesics. ( Duggett, NA; Flatters, SJL; Hopkins, HL, 2016) |
| "Childhood absence epilepsy and juvenile absence epilepsy are among the most common subtypes of IAEs." | 2.48 | Genes and molecular mechanisms involved in the epileptogenesis of idiopathic absence epilepsies. ( Yalçın, O, 2012) |
| "Epilepsy or seizure disorder is one of the most common neurological diseases in humans." | 2.48 | Methylmercury: a potential environmental risk factor contributing to epileptogenesis. ( Yuan, Y, 2012) |
| "Future studies should incorporate secondary hyperalgesia and allodynia as primary parameters." | 2.47 | [Pregabalin and postoperative hyperalgesia. A review]. ( Bornemann-Cimenti, H; Kern-Pirsch, C; Lederer, AJ; Michaeli, K; Sandner-Kiesling, A; Wejbora, M, 2011) |
| "Once established, postherpetic neuralgia is particularly difficult to treat, and is often resistant to conventional analgesics." | 2.47 | [Development of animal models of herpetic pain and postherpetic neuralgia and elucidation of the mechanisms of the onset and inhibition of allodynia]. ( Takasaki, I, 2011) |
| "Schizophrenia is a disorder of cognitive neurodevelopment with characteristic abnormalities in working memory attributed, at least in part, to alterations in the circuitry of the dorsolateral prefrontal cortex." | 2.47 | Postnatal developmental trajectories of neural circuits in the primate prefrontal cortex: identifying sensitive periods for vulnerability to schizophrenia. ( Hoftman, GD; Lewis, DA, 2011) |
| "Schizophrenia is a brain disorder associated with cognitive deficits that severely affect the patients' capacity for daily functioning." | 2.47 | GABA neuron alterations, cortical circuit dysfunction and cognitive deficits in schizophrenia. ( Fish, KN; Gonzalez-Burgos, G; Lewis, DA, 2011) |
| "Levetiracetam (Keppra) is an antiepileptic drug (AED) characterized by a novel mechanism of action, unique profile of activity in seizure models, and broad-spectrum clinical efficacy." | 2.45 | Benefit of combination therapy in epilepsy: a review of the preclinical evidence with levetiracetam. ( Kaminski, RM; Klitgaard, H; Matagne, A; Patsalos, PN, 2009) |
| "In particular, interictal spikes and seizures, especially if prolonged or frequent, may cause acute or long-lasting effects on brain functioning and development, which may impair performance in a variety of behavioral tests." | 2.45 | The epileptic hypothesis: developmentally related arguments based on animal models. ( Galanopoulou, AS; Moshé, SL, 2009) |
| "Angelman syndrome is a neurogenetic disorder characterized by developmental delay, severe intellectual disability, absent speech, exuberant behavior with happy demeanor, motor impairment, and epilepsy, due to deficient UBE3A gene expression that may be caused by various abnormalities of chromosome 15." | 2.45 | Angelman syndrome: current understanding and research prospects. ( Dan, B, 2009) |
| "Cerebral ischemia is a multi-faceted neurodegenerative pathology that causes cellular injury to neurons within the central nervous system." | 2.44 | Anesthetic-mediated protection/preconditioning during cerebral ischemia. ( Clarkson, AN, 2007) |
| "Current treatments of schizophrenia are compromised by their inability to treat all symptoms of the disease and their side-effects." | 2.44 | Modelling prefrontal cortex deficits in schizophrenia: implications for treatment. ( Cochran, SM; Egerton, A; Morris, BJ; Pratt, JA; Winchester, C, 2008) |
| "Murine models of inborn errors of metabolism represent an established approach for investigating pathophysiological mechanisms associated with the corresponding human disorder." | 2.43 | Murine succinate semialdehyde dehydrogenase (SSADH) deficiency, a heritable disorder of GABA metabolism with epileptic phenotype. ( Gibson, KM; Jakobs, C; Pearl, PL; Snead, OC, 2005) |
| "Tinnitus is an auditory phantom sensation of ringing in the ears that is experienced when no external sound is present." | 2.43 | Tinnitus: neurobiological substrates. ( Eggermont, JJ, 2005) |
| "Gabapentin was originally designed as an anti-convulsant gamma-aminobutyric acid (GABA) mimetic capable of crossing the blood-brain barrier." | 2.42 | Cellular and molecular action of the putative GABA-mimetic, gabapentin. ( Chung, FZ; Gonzalez, MI; Lee, K; Maneuf, YP; Pinnock, RD; Sutton, KS, 2003) |
| "3 h, and dose-proportional maximal plasma concentrations and total exposures predict a dose-response relationship in clinical practice and allow an effective starting dose of 150 mg/day in clinical practice without need for titration." | 2.42 | Pregabalin pharmacology and its relevance to clinical practice. ( Ben-Menachem, E, 2004) |
| "Conversely, epileptic seizures have led to the anomalous sprouting of mossy fibers, a process thought to induce hyperexcitation of granule cells." | 2.41 | Functional and morphological changes in the hippocampal neuronal circuits associated with epileptic seizures. ( Ashida, H; Kanda, M; Maru, E, 2002) |
| "Gabapentin is a recently introduced antiepileptic drug for the treatment of partial seizures." | 2.40 | Gabapentin for treatment of epilepsy in children. ( Holmes, GL, 1997) |
| "Generalized epileptic seizures are underlied by specific circuits where GABAergic synapses are involved at different levels." | 2.40 | [GABAergic mechanisms in generalized epilepsies: the neuroanatomical dimension]. ( Depaulis, A; Deransart, C; Marescaux, C; Vergnes, M, 1997) |
| "gamma-Aminobutyric acid (GABA) was first proposed as a putative inhibitory neurotransmitter by Elliot and van Gelder in 1958." | 2.39 | Vigabatrin. ( Ben-Menachem, E, 1995) |
| "Vigabatrin (VGB) was designed specifically to inhibit GABA transaminase and thereby increase the availability of GABA in the brain." | 2.39 | Vigabatrin. ( Ben-Menachem, E, 1995) |
| "Central tinnitus is used herein either to designate a tinnitus that originates in the central auditory system, or to refer to a component of a peripherally generated tinnitus that is exaggerated by auditory brain mechanisms." | 2.39 | Central tinnitus and lateral inhibition: an auditory brainstem model. ( Gerken, GM, 1996) |
| " Excitoxins when infused directly into the Nbm destroy non-specifically cell bodies but spare axons passing the injection site, whereas the specificity of AF64A to destroy cholinergic neurons depends on both the dosage applied and the site of injection." | 2.39 | Immunolesion by 192IgG-saporin of rat basal forebrain cholinergic system: a useful tool to produce cortical cholinergic dysfunction. ( Bigl, V; Rossner, S; Schliebs, R, 1996) |
| "An animal model of chronic spasticity would be valuable." | 2.38 | The spastic mouse. And the search for an animal model of spasticity in human beings. ( Rang, M; Wright, J, 1990) |
| "Definition of other pathways of seizure development and the effects of pharmacologic treatments on discrete brain regions await further research efforts." | 2.37 | Progression and generalization of seizure discharge: anatomical and neurochemical substrates. ( Gale, K, 1988) |
| "A new approach to pathogenetic study of hepatic encephalopathy was recently undertaken in order to identify the neurological alterations of the brain which characterize the coma." | 2.37 | Hepatic encephalopathy. Experimental studies in a rat model of fulminant hepatic failure. ( Zeneroli, ML, 1985) |
| "The inborn seizure response of Papio papio to intermittent light stimulation has been reviewed as a model of human epilepsy." | 2.36 | Photomyoclonic seizures in the baboon, Papio papio. ( Killam, EK, 1979) |
| " Male offsprings were injected with EPO and NEPO in a clinically proper postnatal dosing regimen on postnatal days (PND) 1-5, and autistic-like behaviors were tested at the end of the first month." | 1.91 | The effects of postnatal erythropoietin and nano-erythropoietin on behavioral alterations by mediating K-Cl co-transporter 2 in the valproic acid-induced rat model of autism. ( Basiri, M; Darvishzadeh-Mahani, F; Haratizadeh, S; Nozari, M; Ranjbar, M, 2023) |
| "Mean seizure class did not differ between the treatment groups." | 1.91 | E2730, an uncompetitive γ-aminobutyric acid transporter-1 inhibitor, suppresses epileptic seizures in a rat model of chronic mesial temporal lobe epilepsy. ( Ali, I; Brady, RD; Braine, E; Casillas-Espinosa, PM; Cheng, JY; Fukushima, K; Haskali, MB; Hudson, MR; Jones, NC; Jupp, B; Kwan, P; Major, B; Mychasiuk, R; O'Brien, TJ; Sachdev, P; Shultz, SR; Silva, J; Thergarajan, P; Vivash, L; Wright, DK; Yamakawa, GR, 2023) |
| " Pregnant C57BL/6 J mice were intraperitoneally injected with a dosage of 500 mg/kg valproic acid (VPA) on embryonic day 10." | 1.72 | Size anomaly and alteration of GABAergic enzymes expressions in cerebellum of a valproic acid mouse model of autism. ( Kwan, KM; Ma, SY, 2022) |
| "This study aimed to evaluate the efficacy of gamma-aminobutyric acid (GABA) alone or combined with praziquantel (PZQ) against Schistosoma (S) mansoni infection in a murine model." | 1.72 | Schistosomicidal and hepatoprotective activity of gamma-aminobutyric acid (GABA) alone or combined with praziquantel against Schistosoma mansoni infection in murine model. ( Fahmy, AM; Hegab, A; Tm, D; William, S, 2022) |
| " Significant improvement in hepatic oxidative stress levels, serum albumin and total protein in response to GABA treatment alone or combined with PZQ." | 1.72 | Schistosomicidal and hepatoprotective activity of gamma-aminobutyric acid (GABA) alone or combined with praziquantel against Schistosoma mansoni infection in murine model. ( Fahmy, AM; Hegab, A; Tm, D; William, S, 2022) |
| " Moreover, the voluntary oral administration is suitable for repeated dosing of DREADDs ligands." | 1.72 | Validation of DREADD agonists and administration route in a murine model of sleep enhancement. ( Anaclet, C; Ferrari, LL; Gompf, HS; Ogbeide-Latario, OE, 2022) |
| "Ketamine is a noncompetitive antagonist of N-methyl-D-aspartate receptors (NMDARs)." | 1.72 | Comprehensive metabolomic characterization of the hippocampus in a ketamine mouse model of schizophrenia. ( Cheng, A; Fan, W; Fu, Y; Liao, L; Wang, X; Wei, Y; Wen, D; Xiao, L; Yang, H; Ye, Y, 2022) |
| "Interestingly, astrogliosis observed in the BFB at the pre-plaque stage was absent at the early-plaque stage." | 1.72 | Altered basal forebrain function during whole-brain network activity at pre- and early-plaque stages of Alzheimer's disease in TgF344-AD rats. ( Adhikari, MH; De Vos, WH; Heymans, L; Keliris, GA; Missault, S; Pintelon, I; Ponsaerts, P; Van Audekerke, J; van den Berg, M; Van der Linden, A; Vasilkovska, T; Verhoye, M; Verschuuren, M, 2022) |
| "Absence seizures are hyperexcitations within the cortico-thalamocortical (CTC) network, however the underlying causative mechanisms at the cellular and molecular level are still being elucidated and appear to be multifactorial." | 1.72 | Altered GABA ( Adotevi, NK; Hassan, M; Leitch, B, 2022) |
| "Stress-induced neuroinflammation is widely regarded as one of the primary causes of depression." | 1.72 | Rice Germ Ameliorated Chronic Unpredictable Mild Stress-Induced Depressive-like Behavior by Reducing Neuroinflammation. ( Batsukh, S; Byun, K; Lee, BJ; Oh, S; Park, CH; Rheu, K; Son, KH, 2022) |
| "l-Theanine is an active constituent of green tea which prevents neuronal loss, mitochondrial failure and improves dopamine, gamma-aminobutyric acid (GABA), serotonin levels and in the central nervous system (CNS) via antioxidant, anti-inflammatory, and neuromodulatory properties." | 1.72 | l-Theanine ameliorates motor deficit, mitochondrial dysfunction, and neurodegeneration against chronic tramadol induced rats model of Parkinson's disease. ( Gupta, GD; Raj, K; Singh, S, 2022) |
| " Tramadol is safe analgesic but long-term use confirmed to elevate oxidative stress, neuroinflammation, mitochondrial dysfunction, in brain leads to motor deficits." | 1.72 | l-Theanine ameliorates motor deficit, mitochondrial dysfunction, and neurodegeneration against chronic tramadol induced rats model of Parkinson's disease. ( Gupta, GD; Raj, K; Singh, S, 2022) |
| "In the caffeine-induced insomnia model, the administration of a Saaz-Saphir mixture increased the sleep time compared to Saaz or Saphir administration alone, which was attributed to the increase in NREM sleep time by the δ-wave increase." | 1.62 | GABA ( Ahn, Y; Cho, HJ; Jo, K; Kwak, WK; Min, B; Suh, HJ, 2021) |
| "Migraine is caused by hyperactivity of the trigeminovascular system, where trigeminal ganglia (TG) play an important role." | 1.62 | α6GABA ( Chiou, LC; Cook, J; Fan, PC; Knutson, DE; Lai, TH; Lee, MT; Sieghart, W; Tzeng, HR, 2021) |
| "Established the PCPA insomnia model of mice, The open field test, pentobarbital-induced falling asleep rate, latency of sleeping time, and duration of sleeping time experiments were used to evaluate the behavior of mice, the enzyme-linked immunosorbent assay was used to analyze the content of 5-HT and GABA in hypothalamus and cerebral cortex." | 1.62 | Sedative and hypnotic effects of Perilla frutescens essential oil through GABAergic system pathway. ( Du, Q; Guo, Y; Hu, P; Huang, X; Li, J; Li, W; Liu, S; Ren, G; Shuai, S; Wu, L; Xiao, S; Yang, M; Zhang, K; Zhang, M; Zheng, Q; Zhong, Y; Zhu, L, 2021) |
| "Glaucoma is a leading cause of irreversible blindness worldwide, and increased intraocular pressure (IOP) is a major risk factor." | 1.62 | Early Functional Impairment in Experimental Glaucoma Is Accompanied by Disruption of the GABAergic System and Inceptive Neuroinflammation. ( Elwood, BW; Godwin, CR; Gramlich, OW; Kuehn, MH; Wadkins, D, 2021) |
| "Absence seizures are associated with generalised synchronous 2." | 1.62 | Impact of Dysfunctional Feed-Forward Inhibition on Glutamate Decarboxylase Isoforms and γ-Aminobutyric Acid Transporters. ( Leitch, B; Lyons, NMA; Panthi, S, 2021) |
| "Amantadine treatment also reduces the production of NO and metabolism of GABA." | 1.56 | Amantadine exerts anxiolytic like effect in mice: Evidences for the involvement of nitrergic and GABAergic signaling pathways. ( Garg, C; Garg, M; Walia, V, 2020) |
| "Amantadine is a glutamatergic antagonist that works by inhibiting the NMDA receptor." | 1.56 | Amantadine exerts anxiolytic like effect in mice: Evidences for the involvement of nitrergic and GABAergic signaling pathways. ( Garg, C; Garg, M; Walia, V, 2020) |
| "Current pharmacological treatments for Parkinson's disease (PD) are focused on symptomatic relief, but not on disease modification, based on the strong belief that PD is caused by irreversible dopaminergic neuronal death." | 1.56 | Aberrant Tonic Inhibition of Dopaminergic Neuronal Activity Causes Motor Symptoms in Animal Models of Parkinson's Disease. ( Cho, IJ; Heo, JY; Huh, SH; Hwang, EM; Hwang, O; Hwang, YJ; Im, H; Jang, BK; Jang, DP; Jeon, SR; Jeong, JY; Jin, BK; Jo, S; Kim, HY; Kim, J; Kim, KI; Kim, S; Kim, Y; Kowall, NW; Kweon, GR; Lee, CJ; Lee, HJ; Lee, J; Lee, JA; Lee, MJ; Lee, SE; Nam, MH; Oh, SJ; Paek, SH; Park, HJ; Park, JH; Park, KD; Ryu, H; Shim, I; Shim, JE; Shin, H; Won, W; Woo, DH; Yoon, HH; Yoon, JH, 2020) |
| "VGB was administered for 3 and 7 days." | 1.56 | Long-term vigabatrin treatment modifies pentylenetetrazole-induced seizures in mice: focused on GABA brain concentration. ( Czuczwar, SJ; Krzyżanowski, M; Świąder, K; Świąder, MJ; Wróbel, A; Zakrocka, I; Łuszczki, JJ, 2020) |
| "Convulsions were evoked by PTZ at its CD97 (99 mg/kg)." | 1.56 | Long-term vigabatrin treatment modifies pentylenetetrazole-induced seizures in mice: focused on GABA brain concentration. ( Czuczwar, SJ; Krzyżanowski, M; Świąder, K; Świąder, MJ; Wróbel, A; Zakrocka, I; Łuszczki, JJ, 2020) |
| "Here, we hypothesize that Dravet syndrome may be treated by either enhancing Nav1." | 1.56 | NaV1.1 and NaV1.6 selective compounds reduce the behavior phenotype and epileptiform activity in a novel zebrafish model for Dravet Syndrome. ( Bosma, M; Braun, KPJ; Inserra, M; Koeleman, BPC; Rivara, M; Rook, MB; Singh, S; van 't Slot, RH; Verhoeven-Duif, NM; Vetter, I; Volkers, L; Weuring, WJ, 2020) |
| "Dravet syndrome is caused by dominant loss-of-function mutations in SCN1A which cause reduced activity of Nav1." | 1.56 | NaV1.1 and NaV1.6 selective compounds reduce the behavior phenotype and epileptiform activity in a novel zebrafish model for Dravet Syndrome. ( Bosma, M; Braun, KPJ; Inserra, M; Koeleman, BPC; Rivara, M; Rook, MB; Singh, S; van 't Slot, RH; Verhoeven-Duif, NM; Vetter, I; Volkers, L; Weuring, WJ, 2020) |
| "Chronic hyperammonemia is a common condition affecting individuals with inherited urea cycle disorders resulting in progressive cognitive impairment and behavioral abnormalities." | 1.56 | Chronic hyperammonemia causes a hypoglutamatergic and hyperGABAergic metabolic state associated with neurobehavioral abnormalities in zebrafish larvae. ( Gursky, E; Hoffmann, GF; Kölker, S; Kumar, A; Okun, JG; Peravali, R; Posset, R; Probst, J; Zielonka, M, 2020) |
| " The highest dosage of GABA yogurt had a greater beneficial effect with respect to insulin resistance than the lower dosages." | 1.56 | Effect of γ-aminobutyric acid-rich yogurt on insulin sensitivity in a mouse model of type 2 diabetes mellitus. ( Chen, L; Li, X; Lu, Y; Lu, Z; Zhu, X, 2020) |
| "Down syndrome is a complex genetic disorder caused by the presence of three copies of the chromosome 21 in humans." | 1.56 | Impairment of spatial memory accuracy improved by Cbr1 copy number resumption and GABA ( Amano, K; Arima-Yoshida, F; Fukushima, A; Hattori, S; Kobayashi, S; Manabe, T; Mataga, N; Miyakawa, T; Raveau, M; Sago, H; Shimohata, A; Usui, M; Watanave, M; Yamakawa, K, 2020) |
| "In a mouse model of early parkinsonism, GATs are downregulated, tonic GABAergic inhibition of DA release augmented, and nigrostriatal GABA co-release attenuated." | 1.56 | GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model. ( Bengoa-Vergniory, N; Brimblecombe, KR; Connor-Robson, N; Cragg, SJ; Doig, NM; Lopes, EF; Magill, PJ; Pasternack, N; Roberts, BM; Siddorn, RE; Threlfell, S; Wade-Martins, R, 2020) |
| "Here we report that neuropathic pain-like hypersensitivity induced by common peroneal nerve (CPN) ligation increases nociceptive stimulation-induced responses in glutamatergic LPBN neurons." | 1.56 | Parabrachial nucleus circuit governs neuropathic pain-like behavior. ( Chen, Z; Duan, S; Guo, F; Li, KY; Li, XJ; Li, XY; Li, YY; Liu, R; Ma, XL; Sun, H; Sun, L; Wen, MQ; Wu, MY; Xu, CL; Yu, YQ; Zhu, ZG, 2020) |
| "Depression is one of the most common associated diseases, which aggravates psoriatic skin lesions and affects the life quality of patients." | 1.56 | Depressive-like behaviors in mice with Imiquimod-induced psoriasis. ( Di, T; Guo, J; Guo, X; Li, P; Liu, Y; Meng, Y; Qi, C; Wang, Y; Zhang, L; Zhao, J, 2020) |
| "Psoriasis is not only a chronic inflammatory skin disease but also a psychosomatic disorder." | 1.56 | Depressive-like behaviors in mice with Imiquimod-induced psoriasis. ( Di, T; Guo, J; Guo, X; Li, P; Liu, Y; Meng, Y; Qi, C; Wang, Y; Zhang, L; Zhao, J, 2020) |
| "Alcoholism is often associated with other forms of drug abuse, suggesting that innate predisposing factors may confer vulnerability to addiction to diverse substances." | 1.51 | phMRI, neurochemical and behavioral responses to psychostimulants distinguishing genetically selected alcohol-preferring from genetically heterogenous rats. ( Bifone, A; Cannella, N; Ciccocioppo, R; Cippitelli, A; Domi, E; Gozzi, A; Li, H; Matzeu, A; Scuppa, G; Ubaldi, M; Weiss, F, 2019) |
| "A rat model of neuropathic pain at 6 weeks after spinal nerve ligation (SNL6w) exhibits both mechanical hypersensitivity and impaired noxious stimuli-induced analgesia (NSIA)." | 1.51 | Tropomyosin Receptor Kinase B Receptor Activation in the Locus Coeruleus Restores Impairment of Endogenous Analgesia at a Late Stage Following Nerve Injury in Rats. ( Kato, D; Obata, H; Saito, S; Suto, T, 2019) |
| "Alcohol use disorder is a significant global burden." | 1.51 | Synaptic adaptations in the central amygdala and hypothalamic paraventricular nucleus associated with protracted ethanol abstinence in male rhesus monkeys. ( Cuzon Carlson, VC; Grant, KA; Herman, MA; Jimenez, VA; Roberto, M; Walter, NA, 2019) |
| "Compounds to treat hypothyroidism in the absence of cardiac side effects are urgently required." | 1.51 | Analysis of the protective effects of γ-aminobutyric acid during fluoride-induced hypothyroidism in male Kunming mice. ( Li, P; Liu, S; Xing, R; Yang, H; Yu, H, 2019) |
| " We develop a system in human pluripotent stem cells (hPSCs) using CRISPR/Cas9 and SMASh technology, with which we can target endogenous proteins for precise dosage control in hPSCs and at multiple stages of neural differentiation." | 1.51 | Precisely controlling endogenous protein dosage in hPSCs and derivatives to model FOXG1 syndrome. ( Hu, B; Li, M; Li, W; Mi, T; Mo, F; Teng, Z; Wu, Y; Zhang, B; Zhou, Q; Zhu, W, 2019) |
| "Epilepsy is a prevalent neurological disorder that was reported to affect about 56 million people in the world." | 1.51 | The Anticonvulsant Effects of Baldrinal on Pilocarpine-Induced convulsion in Adult Male Mice. ( Guo, F; Li, X; Liu, N; Ma, L; Sun, T; Yu, J; Zhang, X; Zheng, P; Zhou, R, 2019) |
| "Spontaneous and evoked seizures were evaluated from EEG recordings, and their severity was tested by the Racine scale." | 1.51 | The Anticonvulsant Effects of Baldrinal on Pilocarpine-Induced convulsion in Adult Male Mice. ( Guo, F; Li, X; Liu, N; Ma, L; Sun, T; Yu, J; Zhang, X; Zheng, P; Zhou, R, 2019) |
| "Febrile seizures are a paediatric condition which affects 2-5 % of children worldwide with prolonged febrile seizures (PFS) being found to cause long-term complications and predispose patients to other neurological conditions later in life." | 1.51 | Acetylcholine receptor agonist effect on seizure activity and GABAergic mechanisms involved in prolonged febrile seizure development in an animal model. ( Mabandla, MV; Rakgantsho, C, 2019) |
| "Epilepsy is a group of neurological disorders which affects millions of people worldwide." | 1.51 | Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice. ( Kaszas, A; Malliaras, GG; Proctor, CM; Slezia, A; Williamson, A, 2019) |
| "The mainstay treatment for schizophrenia is antipsychotic drugs (APDs), which are mostly effective against the positive symptoms (e." | 1.51 | Effect of cannabidiol on endocannabinoid, glutamatergic and GABAergic signalling markers in male offspring of a maternal immune activation (poly I:C) model relevant to schizophrenia. ( Babic, I; Huang, XF; Lum, JS; Newell, KA; Osborne, AL; Solowij, N; Weston-Green, K, 2019) |
| "Animals were divided into sham, seizure, exercise (EX), co-seizure-induced exercise (Co-SI EX) and Pre-SI EX groups." | 1.51 | The effect of exercise on GABA signaling pathway in the model of chemically induced seizures. ( Barzroodi Pour, M; Bayat, M; Eftekharzadeh, M; Golab, F; Karimzadeh, F; Katebi, M; Soleimani, M, 2019) |
| "Seizure was induced by pentylentetrazole (PTZ) injection." | 1.51 | The effect of exercise on GABA signaling pathway in the model of chemically induced seizures. ( Barzroodi Pour, M; Bayat, M; Eftekharzadeh, M; Golab, F; Karimzadeh, F; Katebi, M; Soleimani, M, 2019) |
| " Here we performed a dose-response study using fingolimod from 0." | 1.51 | Dual dose-dependent effects of fingolimod in a mouse model of Alzheimer's disease. ( Aytan, N; Carreras, I; Choi, JK; Dedeoglu, A; Jenkins, BG; Kowall, NW; Tognoni, CM, 2019) |
| "Lipid metabolism is abnormal in Alzheimer's disease (AD) brain leading to ceramide and sphingosine accumulation and reduced levels of brain sphingosine-1-phosphate (S1P)." | 1.51 | Dual dose-dependent effects of fingolimod in a mouse model of Alzheimer's disease. ( Aytan, N; Carreras, I; Choi, JK; Dedeoglu, A; Jenkins, BG; Kowall, NW; Tognoni, CM, 2019) |
| "Gallic acid has been reported to possess a number of psychopharmacological activities." | 1.48 | Protective effect of gallic acid in experimental model of ketamine-induced psychosis: possible behaviour, biochemical, neurochemical and cellular alterations. ( Dhingra, MS; Dhingra, S; Jindal, DK; Kumar, A; Parle, M; Yadav, M, 2018) |
| "Mechanical allodynia and thermal hyperalgesia were measured to confirm neuropathic pain induction following before and after gabapentin (GBP) treatment." | 1.48 | Investigation of spinal nerve ligation-mediated functional activation of the rat brain using manganese-enhanced MRI. ( Jeong, KY; Kang, JH, 2018) |
| "The brain regions relating SNL-induced neuropathic pain were as follows: the posterior association area of the parietal region, superior colliculus, inferior colliculus, primary somatosensory area, cingulate cortex, and cingulum bundle." | 1.48 | Investigation of spinal nerve ligation-mediated functional activation of the rat brain using manganese-enhanced MRI. ( Jeong, KY; Kang, JH, 2018) |
| "SNL induced- neuropathic pain is transmitted to the primary somatosensory area and parietal region through the cingulum bundle and limbic system." | 1.48 | Investigation of spinal nerve ligation-mediated functional activation of the rat brain using manganese-enhanced MRI. ( Jeong, KY; Kang, JH, 2018) |
| "Neuropathic pain was severely induced by SNL on the postoperative day 14, excepting the sham group." | 1.48 | Investigation of spinal nerve ligation-mediated functional activation of the rat brain using manganese-enhanced MRI. ( Jeong, KY; Kang, JH, 2018) |
| "While S 38093 did not change vocalization thresholds to paw pressure in healthy rats, it exhibited a significant antihyperalgesic effect in the Streptozocin-induced diabetic (STZ) neuropathy model after acute and chronic administration and, in the chronic constriction injury (CCI) model only after chronic administration, submitted to the paw-pressure test." | 1.48 | Effects of S 38093, an antagonist/inverse agonist of histamine H3 receptors, in models of neuropathic pain in rats. ( Ardid, D; Berrocoso, E; Bravo, L; Chalus, M; Chapuy, E; Chaumette, T; Eschalier, A; Llorca-Torralba, M; Marchand, F; Mico, JA; Sors, A, 2018) |
| "This effect of S 38093 in neuropathic pain could be partly mediated by α2 receptors desensitization in the locus coeruleus." | 1.48 | Effects of S 38093, an antagonist/inverse agonist of histamine H3 receptors, in models of neuropathic pain in rats. ( Ardid, D; Berrocoso, E; Bravo, L; Chalus, M; Chapuy, E; Chaumette, T; Eschalier, A; Llorca-Torralba, M; Marchand, F; Mico, JA; Sors, A, 2018) |
| "Moreover, in mice carrying an Alzheimer's disease-related mutation in presenilin 1, astrocytes accumulated GABA even in the absence of amyloidosis." | 1.48 | A bell-shaped dependence between amyloidosis and GABA accumulation in astrocytes in a mouse model of Alzheimer's disease. ( Brawek, B; Chesters, R; Garaschuk, O; Hermes, M; Klement, D; Lerdkrai, C; Müller, J, 2018) |
| "Age and sex are risk factors of Alzheimer's disease (AD)." | 1.48 | Sex- and age-specific modulation of brain GABA levels in a mouse model of Alzheimer's disease. ( Alia, A; Hartlage-Rübsamen, M; Höfling, C; Matysik, J; Roy, U; Roβner, S; Stute, L, 2018) |
| "Neuropathic pain is among the most common and difficult-to-treat types of chronic pain and is associated with sodium channel malfunction." | 1.48 | Effects of ralfinamide in models of nerve injury and chemotherapy-induced neuropathic pain. ( Liang, X; Su, R; Yu, G, 2018) |
| "Left sciatic nerve ligation was used as neuropathic pain model." | 1.48 | Efficacy and safety of combined low doses of either diclofenac or celecoxib with gabapentin versus their single high dose in treatment of neuropathic pain in rats. ( Abdelwahab, S; Abdelzaher, WY; Ibrahim, MA; Rofaeil, RR, 2018) |
| "Neuropathic pain is a worldwide health problem with no consensus regarding its optimal therapy." | 1.48 | Efficacy and safety of combined low doses of either diclofenac or celecoxib with gabapentin versus their single high dose in treatment of neuropathic pain in rats. ( Abdelwahab, S; Abdelzaher, WY; Ibrahim, MA; Rofaeil, RR, 2018) |
| "Absence seizures (ASs) are associated with abnormalities in gamma-aminobutyric acid (GABA) neurotransmission in the thalamus and the cortex." | 1.48 | Developmental changes of GABA immunoreactivity in cortico-thalamic networks of an absence seizure model. ( Bombardi, C; Crunelli, V; Di Giovanni, G; Venzi, M, 2018) |
| "Von Frey filaments were used to assess tactile allodynia." | 1.48 | Evaluation of the neonatal streptozotocin model of diabetes in rats: Evidence for a model of neuropathic pain. ( Barragán-Iglesias, P; Delgado-Lezama, R; Granados-Soto, V; Hong, E; Loeza-Alcocer, E; Oidor-Chan, VH; Pineda-Farias, JB; Price, TJ; Salinas-Abarca, AB; Sánchez-Mendoza, A; Velazquez-Lagunas, I, 2018) |
| " We investigated the effect of long-term administration of ERI in three different doses on behavioral changes, hippocampal and prefrontal cortex (PFC) neurogenesis, and γ-aminobutyric acid (GABA)/glutamate balance in male Wistar rats exposed to chronic restraint stress (CRS)." | 1.48 | Behavioral effects of toll-like receptor-4 antagonist 'eritoran' in an experimental model of depression: role of prefrontal and hippocampal neurogenesis and γ-aminobutyric acid/glutamate balance. ( Aboul-Fotouh, S; Asaad, T; Ghanem, MH; Habib, M; Kassim, SK, 2018) |
| "Depression is the disease of the modern era." | 1.48 | Behavioral effects of toll-like receptor-4 antagonist 'eritoran' in an experimental model of depression: role of prefrontal and hippocampal neurogenesis and γ-aminobutyric acid/glutamate balance. ( Aboul-Fotouh, S; Asaad, T; Ghanem, MH; Habib, M; Kassim, SK, 2018) |
| "Stigmasterol treated animals showed significant decrease in locomotor activity, stereotypic behaviours, immobility duration and increased step down latency." | 1.48 | Protective effects of stigmasterol against ketamine-induced psychotic symptoms: Possible behavioral, biochemical and histopathological changes in mice. ( Dhingra, S; Jindal, DK; Parle, M; Yadav, M, 2018) |
| "Epilepsy is associated with increased morbidity and mortality together and places a large financial burden on individuals and society." | 1.48 | Anticonvulsive effects of protodioscin against pilocarpine-induced epilepsy. ( Chen, Y; Fajol, A; Ren, B; Shi, S; Song, S, 2018) |
| "Sleep disorders are common in Alzheimer's disease (AD) and assumed to directly influence cognitive function and disease progression." | 1.48 | Intracerebroventricular streptozotocin-induced Alzheimer's disease-like sleep disorders in rats: Role of the GABAergic system in the parabrachial complex. ( Cui, SY; Cui, XY; Ding, H; Ge, YR; Hu, X; Luo, Y; Ma, YN; Shi, YT; Song, JZ; Ye, H; Zhang, YH, 2018) |
| "Neuropathic pain was induced by a chronic constriction injury of the sciatic nerve (CCI) and mechanical allodynia and the spatial memory was assessed using the Von Frey filaments and Morris water maze respectively." | 1.46 | In vivo evaluation of the hippocampal glutamate, GABA and the BDNF levels associated with spatial memory performance in a rodent model of neuropathic pain. ( Farahmandfar, M; Janzadeh, A; Naghdi, N; Nasirinezhad, F; Saffarpour, S; Shaabani, M, 2017) |
| "A distinct acute, severe form of neuropathic pain, called insulin neuritis or treatment-induced painful neuropathy of diabetes (TIND), may also occur shortly after initiation of intensive glycemic control, with an incidence rate of up to 10." | 1.46 | Murine model and mechanisms of treatment-induced painful diabetic neuropathy. ( Anaya, CJ; Enriquez, C; Jolivalt, CG; Marquez, A; Nicodemus, JM, 2017) |
| "Secondary generalized seizure (sGS) is a major source of disability in temporal lobe epilepsy (TLE) with unclear cellular/circuit mechanisms." | 1.46 | Depolarized GABAergic Signaling in Subicular Microcircuits Mediates Generalized Seizure in Temporal Lobe Epilepsy. ( Chen, B; Chen, Z; Duan, S; Gao, F; Guo, Y; Ji, C; Li, X; Liang, J; Luo, J; Wang, S; Wang, Y; Wu, X; Xu, C; Xu, Z, 2017) |
| "Chronic pain, neuropathic pain, inflammatory pain, ozone therapy, interventional therapy, gabapentin, spared nerve injury, bee venom, complete Freud's adjuvant." | 1.46 | Intervertebral Foramen Injection of Ozone Relieves Mechanical Allodynia and Enhances Analgesic Effect of Gabapentin in Animal Model of Neuropathic Pain. ( Chen, J; Guan, SM; Luo, WJ; Sun, W; Wang, JL; Wang, JS; Wang, XL; Wu, FF; Yang, F; Zheng, W, 2017) |
| "Gabapentin (GBP) is a first-line therapy for neuropathic pain, but its mechanisms and sites of action remain uncertain." | 1.46 | Multiple sites and actions of gabapentin-induced relief of ongoing experimental neuropathic pain. ( Bannister, K; Dickenson, AH; King, T; Navratilova, E; Oyarzo, J; Porreca, F; Qu, C; Xie, JY, 2017) |
| "The novel therapeutic strategy against autism is essential due to the limited therapeutic efficacy." | 1.46 | Laser Acupuncture at HT7 Improves the Cerebellar Disorders in Valproic Acid-Rat Model of Autism. ( Khongrum, J; Wattanathorn, J, 2017) |
| "Diazepam, however, was more effective than escitalopram in suppressing MB." | 1.46 | Marble burying as compulsive behaviors in male and female mice. ( Chourbaji, S; Lerch, S; Taylor, GT, 2017) |
| "Pyridoxine-sensitive seizures characterize severe forms of infantile HPP." | 1.46 | Neuromuscular features of hypophosphatasia. ( Fonta, C; Salles, JP, 2017) |
| " Since brain-derived neurotrophic factor (BDNF) promotes GABAergic synaptogenesis, we hypothesized that individual differences in this vulnerability may arise from differences in the link between BDNF bioavailability and FR-evoked wheel running." | 1.46 | Variant BDNF-Val66Met Polymorphism is Associated with Layer-Specific Alterations in GABAergic Innervation of Pyramidal Neurons, Elevated Anxiety and Reduced Vulnerability of Adolescent Male Mice to Activity-Based Anorexia. ( Aoki, C; Chen, YW; Lee, F; Rana, BS; Surgent, O, 2017) |
| "Understanding the seizure-inducing mechanisms of TBI is of the utmost importance, because these seizures are often resistant to traditional first- and second-line anti-seizure treatments." | 1.46 | NKCC1 up-regulation contributes to early post-traumatic seizures and increased post-traumatic seizure susceptibility. ( Cotrina, ML; Gu, S; He, X; Huang, JH; Liu, W; Nedergaard, M; Shapiro, LA; Wang, EW; Wang, F; Wang, W; Wang, X, 2017) |
| "Treatment with gabapentin, but not amitriptyline, was associated with a complete attenuation of hind paw mechanical hypersensitivity observed with indinavir treatment." | 1.46 | A rodent model of HIV protease inhibitor indinavir induced peripheral neuropathy. ( Bennett, DLH; Calvo, M; Huang, W; Pheby, T; Rice, ASC, 2017) |
| "It often presents with significant neuropathic pain and is associated with previous exposure to neurotoxic nucleoside reverse transcriptase inhibitors." | 1.46 | A rodent model of HIV protease inhibitor indinavir induced peripheral neuropathy. ( Bennett, DLH; Calvo, M; Huang, W; Pheby, T; Rice, ASC, 2017) |
| "Gabapentin gel (10% w/w) was applied three times daily on the ipsilateral or contralateral plantar surface of the hind-paw, whereas in a concurrent systemic study, gabapentin was intraperitoneally administered daily (75 mg/kg) for 30 days." | 1.46 | Topical gabapentin gel alleviates allodynia and hyperalgesia in the chronic sciatic nerve constriction injury neuropathic pain model. ( Ahmad, N; Akbar, S; Ali, G; Fawad, K; Sewell, RD; Shahid, M; Subhan, F, 2017) |
| "Tests for static- and dynamic-mechano-allodynia [paw withdrawal threshold (PWT) to von Frey filament application and latency (PWL) to light brushing], cold-allodynia [paw withdrawal duration (PWD) to acetone], heat- (PWL and PWD) and mechano-hyperalgesia (PWD to pin prick) were utilized to assess pain, whereas effects on locomotion (open field) and motor balance (rotarod and footprint analysis) were measured on days 5-30 post surgery." | 1.46 | Topical gabapentin gel alleviates allodynia and hyperalgesia in the chronic sciatic nerve constriction injury neuropathic pain model. ( Ahmad, N; Akbar, S; Ali, G; Fawad, K; Sewell, RD; Shahid, M; Subhan, F, 2017) |
| "Systemic gabapentin neuropathic pain management carries side-effects ostensibly preventable by localized therapy." | 1.46 | Topical gabapentin gel alleviates allodynia and hyperalgesia in the chronic sciatic nerve constriction injury neuropathic pain model. ( Ahmad, N; Akbar, S; Ali, G; Fawad, K; Sewell, RD; Shahid, M; Subhan, F, 2017) |
| "Chronic pain is a multifactorial disease comprised of both inflammatory and neuropathic components that affect ∼20% of the world's population." | 1.46 | sec-Butylpropylacetamide (SPD), a new amide derivative of valproic acid for the treatment of neuropathic and inflammatory pain. ( Bialer, M; Brennan, KC; Devor, M; Kaufmann, D; Smith, MD; West, PJ; White, HS; Yagen, B, 2017) |
| "Type 1 diabetes is characterized by the destruction of pancreatic β cells, and generating new insulin-producing cells from other cell types is a major aim of regenerative medicine." | 1.46 | Artemisinins Target GABA ( Avolio, F; Baburin, I; Barbieux, C; Bennett, KL; Berishvili, E; Bock, C; Briand, F; Casteels, T; Colinge, J; Collombat, P; Courtney, M; Distel, M; Farlik, M; Frogne, T; Gridling, M; Harkany, T; Hecksher-Sørensen, J; Hering, S; Honoré, C; Huber, KVM; Ingvorsen, C; Kimmel, RA; Klughammer, J; Kubicek, S; Lardeau, CH; Li, J; Májek, P; Meyer, D; Parapatics, K; Pauler, FM; Penz, T; Romanov, RA; Schmitner, N; Sdelci, S; Spittler, A; Stukalov, A; Sturtzel, C; Sulpice, T; Superti-Furga, G; Vieira, A, 2017) |
| "Using 3 rat models of neuropathic pain of toxic (oxaliplatin/OXA), metabolic (streptozocin/STZ), and traumatic (sciatic nerve ligation/CCI [chronic constriction nerve injury]) etiologies, we investigated the antihypersensitivity effect of acute and repeated agomelatine administration." | 1.46 | Agomelatine: a new opportunity to reduce neuropathic pain-preclinical evidence. ( Authier, N; Bertrand, M; Chapuy, E; Chenaf, C; Courteix, C; Eschalier, A; Gabriel, C; Libert, F; Marchand, F; Mocaër, E, 2017) |
| "Huntington Disease is autosomal, fatal and progressive neurodegenerative disorder for which clinically available drugs offer only symptomatic relief." | 1.46 | Sertraline and venlafaxine improves motor performance and neurobehavioral deficit in quinolinic acid induced Huntington's like symptoms in rats: Possible neurotransmitters modulation. ( Deshmukh, R; Gill, JS; Jamwal, S; Kumar, P, 2017) |
| "Daily gabapentin treatment attenuated mechanical allodynia and reduced face-grooming episodes in dIoN-CCI rats." | 1.46 | An Improved Rodent Model of Trigeminal Neuropathic Pain by Unilateral Chronic Constriction Injury of Distal Infraorbital Nerve. ( Chen, L; Ding, W; Doheny, JT; Lim, G; Mao, J; Shen, S; Yang, J; You, Z; Zhu, S, 2017) |
| "A rodent model of trigeminal neuropathic pain was first developed in 1994, in which chronic constriction injury (CCI) is induced by ligation of the infraorbital nerve (IoN)." | 1.46 | An Improved Rodent Model of Trigeminal Neuropathic Pain by Unilateral Chronic Constriction Injury of Distal Infraorbital Nerve. ( Chen, L; Ding, W; Doheny, JT; Lim, G; Mao, J; Shen, S; Yang, J; You, Z; Zhu, S, 2017) |
| "However, studies on trigeminal neuropathic pain remain limited." | 1.46 | An Improved Rodent Model of Trigeminal Neuropathic Pain by Unilateral Chronic Constriction Injury of Distal Infraorbital Nerve. ( Chen, L; Ding, W; Doheny, JT; Lim, G; Mao, J; Shen, S; Yang, J; You, Z; Zhu, S, 2017) |
| "Inflammation is considered to be one of the crucial pathological factors associated with the development of Alzheimer's disease, although supportive experimental evidence remains undiscovered." | 1.46 | Immunological alteration & toxic molecular inductions leading to cognitive impairment & neurotoxicity in transgenic mouse model of Alzheimer's disease. ( Abdel-Rahman, E; Ahuja, M; Amin, R; Buabeid, M; Dhanasekaran, M; Majrashi, M; Parameshwaran, K; Pondugula, S; Ramesh, S; Suppiramaniam, V; Thiruchelvan, K, 2017) |
| "The 6-Hz-induced seizures were accompanied by reduced brain 5-HT, DA, NE, histamine, GABA, and enhanced glutamate levels." | 1.46 | Parachlorophenylalanine-induced 5-HT depletion alters behavioral and brain neurotransmitters levels in 6-Hz psychomotor seizure model in mice. ( Jahan, K; Pillai, KK; Vohora, D, 2017) |
| "Patients with liver disease may develop hepatic encephalopathy (HE), with cognitive impairment and motor in-coordination." | 1.46 | Sildenafil reduces neuroinflammation in cerebellum, restores GABAergic tone, and improves motor in-coordination in rats with hepatic encephalopathy. ( Agusti, A; Balzano, T; Cabrera-Pastor, A; Felipo, V; Fustero, S; Hernández-Rabaza, V; Ibañez-Grau, A; Llansola, M; Montoliu, C; Taoro-Gonzalez, L, 2017) |
| "The Dunning rat model of prostate cancer was used." | 1.43 | Gabapentin, an Analgesic Used Against Cancer-Associated Neuropathic Pain: Effects on Prostate Cancer Progression in an In Vivo Rat Model. ( Altun, S; Bugan, I; Djamgoz, MB; Karagoz, Z, 2016) |
| "Both phases display robust tactile allodynia." | 1.43 | The effect of gabapentin and ketorolac on allodynia and conditioned place preference in antibody-induced inflammation. ( Corr, M; McQueen, J; Park, HJ; Sandor, K; Svensson, CI; Woller, SA; Yaksh, TL, 2016) |
| "After onset of inflammation and allodynia, we assessed effects of i." | 1.43 | The effect of gabapentin and ketorolac on allodynia and conditioned place preference in antibody-induced inflammation. ( Corr, M; McQueen, J; Park, HJ; Sandor, K; Svensson, CI; Woller, SA; Yaksh, TL, 2016) |
| "Consistent with the effects upon allodynia, both gabapentin and ketorolac produced a preference for the drug-paired compartment in the early phase of the K/BxN model, while gabapentin, but not ketorolac, resulted in a place preference during late phase." | 1.43 | The effect of gabapentin and ketorolac on allodynia and conditioned place preference in antibody-induced inflammation. ( Corr, M; McQueen, J; Park, HJ; Sandor, K; Svensson, CI; Woller, SA; Yaksh, TL, 2016) |
| "The pharmacotherapy for neuropathic pain includes gabapentin and tramadol, but these are only partially effective when given alone." | 1.43 | Antinociceptive Interaction of Tramadol with Gabapentin in Experimental Mononeuropathic Pain. ( Aranda, N; Castillo, R; Miranda, HF; Noriega, V; Prieto, JC; Sierralta, F; Zanetta, P, 2016) |
| "Neuropathic pain is the result of injury to the nervous system, and different animal models have been established to meet the manifestations of neuropathy." | 1.43 | Antinociceptive Interaction of Tramadol with Gabapentin in Experimental Mononeuropathic Pain. ( Aranda, N; Castillo, R; Miranda, HF; Noriega, V; Prieto, JC; Sierralta, F; Zanetta, P, 2016) |
| "The results confirm activity in chronic pain models predicted from affinity for the gabapentin site and suggests, at least partially, that α2δ-subunits of presynaptic voltage-gated calcium channels are involved in mediating this effect." | 1.43 | Optical isomers of phenibut inhibit [H(3)]-Gabapentin binding in vitro and show activity in animal models of chronic pain. ( Belozertseva, I; Danysz, W; Franke, L; Nagel, J; Valastro, B, 2016) |
| "Vigabatrin is a clinically approved anti-seizure drug, which acts by increasing brain GABA levels by irreversibly inhibiting GABA-aminotransferase (GABA-T)." | 1.43 | Continuous bilateral infusion of vigabatrin into the subthalamic nucleus: Effects on seizure threshold and GABA metabolism in two rat models. ( Gernert, M; Gey, L; Löscher, W, 2016) |
| " The data demonstrate that chronic administration of very low, nontoxic doses of vigabatrin into STN is an effective means of increasing local GABA concentrations and seizure threshold." | 1.43 | Continuous bilateral infusion of vigabatrin into the subthalamic nucleus: Effects on seizure threshold and GABA metabolism in two rat models. ( Gernert, M; Gey, L; Löscher, W, 2016) |
| "We obtained seizures and once they had 3, 15 and 45 electric stimuli, the animals were sacrificed; the cerebellum was processed for inmunohistochemistry and Western blot analysis was performed to determine Sox-1 expression." | 1.43 | Decreased Expression of Sox-1 in Cerebellum of Rat with Generalized Seizures Induced by Kindling Model. ( Custodio, V; Eguiluz-Meléndez, A; González, E; Martínez-Lazcano, JC; Paz, C; Rosiles-Abonce, A; Rubio-Osornio, C; Rubio-Osornio, M; Trejo-Solís, C, 2016) |
| "L-Dopa continues to be the gold drug in Parkinson's disease (PD) treatment from 1967." | 1.43 | Aminochrome induces dopaminergic neuronal dysfunction: a new animal model for Parkinson's disease. ( Abarca, J; Cardenas, C; Díaz-Veliz, G; Gysling, K; Herrera, A; Hultenby, K; Inzunza, J; Jaña, F; Mora, S; Muñoz, P; Paris, I; Raisman-Vozari, R; Segura-Aguilar, J; Steinbusch, HW, 2016) |
| "In the nerve injury model of neuropathic pain, WNK1/HSN2 contributed to a maladaptive decrease in the activity of the K(+)-Cl(-)cotransporter KCC2 by increasing its inhibitory phosphorylation at Thr(906)and Thr(1007), resulting in an associated loss of GABA (γ-aminobutyric acid)-mediated inhibition of spinal pain-transmitting nerves." | 1.43 | Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition. ( Andrews, N; Castonguay, G; Dion, PA; Duan, J; Gaudet, R; Hince, P; Inquimbert, P; Kahle, KT; Khanna, AR; Laganière, J; Latremoliere, A; Lavastre, V; Mapplebeck, JC; Mogil, JS; Omura, T; Rochefort, D; Rouleau, GA; Schmouth, JF; Sotocinal, SG; Ward, C; Woolf, CJ; Zhang, J, 2016) |
| "Preclinical Research Neuropathic pain is particularly difficult to treat because of its diverse etiologies and underlying pathophysiological mechanisms." | 1.43 | Antinociceptive Interactions Between Meloxicam and Gabapentin in Neuropathic Pain Depend on the Ratio used in Combination in Rats. ( Corona-Ramos, JN; Espinosa-Juárez, JV; Jaramillo-Morales, OA; López-Muñoz, FJ; Medina-López, JR, 2016) |
| "Sulforaphane promotes polarization of microglia from the M1 to the M2 phenotype, reducing IL-1b and increasing IL-4, IL-10, Arg1, and YM-1 in the cerebellum." | 1.43 | Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia. ( Agusti, A; Balzano, T; Cabrera-Pastor, A; Felipo, V; Gonzalez-Usano, A; Hernandez-Rabaza, V; Llansola, M; Taoro-Gonzalez, L, 2016) |
| "In a seizure model caused by a mutation in the ionotropic acetylcholine receptor acr-2(gf), dnj-17(gf) exacerbates the convulsion phenotype in conjunction with absence of GABA." | 1.43 | Altered Function of the DnaJ Family Cochaperone DNJ-17 Modulates Locomotor Circuit Activity in a Caenorhabditis elegans Seizure Model. ( Jin, Y; Takayanagi-Kiya, S, 2016) |
| "After MPNL, mechanical allodynia was established, and mice quickly recovered from the surgery without any significant motor impairment." | 1.43 | Medial plantar nerve ligation as a novel model of neuropathic pain in mice: pharmacological and molecular characterization. ( Alves-Filho, JC; Bassi, GS; Bozzo, TA; Cunha, FQ; Cunha, TM; Ferreira, SH; Kusuda, R; Sant'Anna, MB; Souza, GR, 2016) |
| "Peripheral neuropathic pain is a consequence of an injury/disease of the peripheral nerves." | 1.43 | Medial plantar nerve ligation as a novel model of neuropathic pain in mice: pharmacological and molecular characterization. ( Alves-Filho, JC; Bassi, GS; Bozzo, TA; Cunha, FQ; Cunha, TM; Ferreira, SH; Kusuda, R; Sant'Anna, MB; Souza, GR, 2016) |
| "In the present study, we found that neuropathic pain induced by the chemotherapeutic drug paclitaxel or L5 ventral root transection significantly impaired the function of GABAergic synapses of spinal dorsal horn neurons via the reduction of the GAD67 expression." | 1.43 | mir-500-Mediated GAD67 Downregulation Contributes to Neuropathic Pain. ( Huang, ZZ; Li, D; Liu, CC; Ma, C; Ou-Yang, HD; Wei, JY; Wu, SL; Xin, WJ; Xu, T; Zhang, XL, 2016) |
| "Neuropathic pain is a common neurobiological disease involving multifaceted maladaptations ranging from gene modulation to synaptic dysfunction, but the interactions between synaptic dysfunction and the genes that are involved in persistent pain remain elusive." | 1.43 | mir-500-Mediated GAD67 Downregulation Contributes to Neuropathic Pain. ( Huang, ZZ; Li, D; Liu, CC; Ma, C; Ou-Yang, HD; Wei, JY; Wu, SL; Xin, WJ; Xu, T; Zhang, XL, 2016) |
| "Neuropathic pain is a common neurobiological disease involving multifaceted maladaptations ranging from gene modulation to synaptic dysfunction, but the underlying molecular mechanisms remain elusive." | 1.43 | mir-500-Mediated GAD67 Downregulation Contributes to Neuropathic Pain. ( Huang, ZZ; Li, D; Liu, CC; Ma, C; Ou-Yang, HD; Wei, JY; Wu, SL; Xin, WJ; Xu, T; Zhang, XL, 2016) |
| " Dose-response curves (DRC) and isobolographic analysis were used to confirm their synergistic antihyperalgesic and anti-allodynic responses in a rat neuropathic pain model involving chronic constriction injury of the sciatic nerve and in von Frey and acetone tests." | 1.43 | The Antinociceptive Effects of Tramadol and/or Gabapentin on Rat Neuropathic Pain Induced by a Chronic Constriction Injury. ( Corona-Ramos, JN; De la O-Arciniega, M; Déciga-Campos, M; Domínguez-Ramírez, AM; Espinosa-Juárez, JV; Jaramillo-Morales, OA; López-Muñoz, FJ; Medina-López, JR, 2016) |
| "Cathepsin S inhibitors attenuate mechanical allodynia in preclinical neuropathic pain models." | 1.43 | Selective Cathepsin S Inhibition with MIV-247 Attenuates Mechanical Allodynia and Enhances the Antiallodynic Effects of Gabapentin and Pregabalin in a Mouse Model of Neuropathic Pain. ( Classon, B; Edenius, C; Grabowska, U; Henderson, I; Hewitt, E; Lindström, E; Malcangio, M; Pitcher, T; Rizoska, B; Sahlberg, BL; Tunblad, K, 2016) |
| "Mechanical allodynia was assessed using von Frey hairs." | 1.43 | Selective Cathepsin S Inhibition with MIV-247 Attenuates Mechanical Allodynia and Enhances the Antiallodynic Effects of Gabapentin and Pregabalin in a Mouse Model of Neuropathic Pain. ( Classon, B; Edenius, C; Grabowska, U; Henderson, I; Hewitt, E; Lindström, E; Malcangio, M; Pitcher, T; Rizoska, B; Sahlberg, BL; Tunblad, K, 2016) |
| "Episodic ataxia type 1 is caused by missense mutations of the potassium channel Kv1." | 1.43 | Action potential broadening in a presynaptic channelopathy. ( Bakiri, Y; Begum, R; Kullmann, DM; Volynski, KE, 2016) |
| "Memantine was used as a positive control." | 1.43 | Low dose of L-glutamic acid attenuated the neurological dysfunctions and excitotoxicity in bilateral common carotid artery occluded mice. ( Abdul, KK; Justin, A; Ramanathan, M, 2016) |
| "Mechanical allodynia elicited by burn injury was partially reversed by meloxicam (5 mg/kg), gabapentin (100 mg/kg) and oxycodone (3 and 10 mg/kg), while thermal allodynia and gait abnormalities were only significantly improved by amitriptyline (3 mg/kg) and oxycodone (10 mg/kg)." | 1.43 | Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target. ( Deuis, JR; Lewis, RJ; Vetter, I; Yin, K, 2016) |
| " Although there was no difference in kainate dosing or seizure count between them, the metabolic pattern of injury was different." | 1.43 | Metabolic injury in a variable rat model of post-status epilepticus. ( de Lanerolle, N; Kelly, KM; Pan, JW; Pearce, PS; Rapuano, A; Wu, Y, 2016) |
| "Robust allodynia was observed in all three ligation groups." | 1.42 | Ligation of mouse L4 and L5 spinal nerves produces robust allodynia without major motor function deficit. ( Baker, KB; Lanthorn, TH; Mason, S; Rajan, I; Savelieva, KV; Vogel, P; Ye, GL, 2015) |
| " Systemic nicotine given before the sample phase of the CMOR task reversed the ketamine-induced impairment, but this effect was blocked by co-administration of the GABAA receptor antagonist bicuculline at a dosage that itself did not cause impairment." | 1.42 | α₄β₂ Nicotinic receptor stimulation of the GABAergic system within the orbitofrontal cortex ameliorates the severe crossmodal object recognition impairment in ketamine-treated rats: implications for cognitive dysfunction in schizophrenia. ( Cloke, JM; Winters, BD, 2015) |
| "Schizophrenia is associated with atypical multisensory integration." | 1.42 | α₄β₂ Nicotinic receptor stimulation of the GABAergic system within the orbitofrontal cortex ameliorates the severe crossmodal object recognition impairment in ketamine-treated rats: implications for cognitive dysfunction in schizophrenia. ( Cloke, JM; Winters, BD, 2015) |
| "The GABAergic deficit hypothesis of major depressive disorders (MDDs) posits that reduced γ-aminobutyric acid (GABA) concentration in brain, impaired function of GABAergic interneurons, altered expression and function of GABA(A) receptors, and changes in GABAergic transmission dictated by altered chloride homeostasis can contribute to the etiology of MDD." | 1.42 | GABAergic control of depression-related brain states. ( Fuchs, T; Luscher, B, 2015) |
| "Paclitaxel treatment resulted in thermal hyperalgesia and in increased GABA transporter-1 (GAT-1) mRNA expression, but not that of other GABA transporters or GABA(A) ergic enzymes in the ACC compared to vehicle treatment." | 1.42 | Comprehensive analysis of the GABAergic system gene expression profile in the anterior cingulate cortex of mice with Paclitaxel-induced neuropathic pain. ( Masocha, W, 2015) |
| "Allergic rhinitis was induced in mice by two intra-peritoneal injections of ovalbumin administered with a one-week interval." | 1.42 | Stability of the synaptic structure in the hippocampus of BALB/c mice with allergic rhinitis. ( Jinno, S; Komune, S; Kubo, K; Nariyama, K, 2015) |
| "Gabapentin was effective in transiently reversing mechanical allodynia in those mice with lowered thresholds." | 1.42 | Differences in cisplatin-induced mechanical allodynia in male and female mice. ( Corr, M; Woller, SA; Yaksh, TL, 2015) |
| "Male WT mice develop a persistent tactile allodynia resulting from cisplatin administration." | 1.42 | Differences in cisplatin-induced mechanical allodynia in male and female mice. ( Corr, M; Woller, SA; Yaksh, TL, 2015) |
| "Diclofenac treatment produced dose-related reversal of CRANE at 0." | 1.42 | Complete Freund's adjuvant-induced reduction of exploratory activity in a novel environment as an objective nociceptive endpoint for sub-acute inflammatory pain model in rats. ( Bannon, AW; Joshi, SK; Zhu, CZ, 2015) |
| " Effects of orally dosed standard analgesics on CRANE were examined 48 h following bilateral CFA injection." | 1.42 | Complete Freund's adjuvant-induced reduction of exploratory activity in a novel environment as an objective nociceptive endpoint for sub-acute inflammatory pain model in rats. ( Bannon, AW; Joshi, SK; Zhu, CZ, 2015) |
| "A hallmark of peripheral neuropathic pain (PNP) is chronic spontaneous pain and/or hypersensitivity to normally painful stimuli (hyperalgesia) or normally nonpainful stimuli (allodynia)." | 1.42 | Increased expression of HCN2 channel protein in L4 dorsal root ganglion neurons following axotomy of L5- and inflammation of L4-spinal nerves in rats. ( Al Otaibi, M; Djouhri, L; Sathish, J; Smith, T, 2015) |
| "Paclitaxel is a chemotherapeutic agent widely used for treating carcinomas." | 1.42 | Blocking the GABA transporter GAT-1 ameliorates spinal GABAergic disinhibition and neuropathic pain induced by paclitaxel. ( Gao, M; Maixner, DW; Weng, HR; Yadav, R; Yan, X, 2015) |
| "In rats with paclitaxel-induced neuropathic pain, the protein expression of GAT-1 was increased while GAT-3 was decreased." | 1.42 | Blocking the GABA transporter GAT-1 ameliorates spinal GABAergic disinhibition and neuropathic pain induced by paclitaxel. ( Gao, M; Maixner, DW; Weng, HR; Yadav, R; Yan, X, 2015) |
| " In this study, we tested the hypothesis that HIV gp120 combined with antiretroviral therapy reduces spinal GABAergic inhibitory tone and that restoration of GABAergic inhibitory tone will reduce HIV-related NP in a rat model." | 1.42 | Gene Transfer of Glutamic Acid Decarboxylase 67 by Herpes Simplex Virus Vectors Suppresses Neuropathic Pain Induced by Human Immunodeficiency Virus gp120 Combined with ddC in Rats. ( Candiotti, KA; Hao, S; Huang, W; Kanao, M; Kanda, H; Levitt, RC; Liu, S; Lubarsky, DA; Yi, H, 2015) |
| "Adenosine is an inhibitory neuromodulator that was previously thought to mediate antinociception through the A1 and A2A receptor subtypes." | 1.42 | Engagement of the GABA to KCC2 signaling pathway contributes to the analgesic effects of A3AR agonists in neuropathic pain. ( Castonguay, A; Chen, Z; Cottet, M; De Koninck, Y; Doyle, T; Egan, TM; Ford, A; Jacobson, KA; Little, JW; Salvemini, D; Symons-Liguori, AM; Tosh, DK; Vanderah, TW, 2015) |
| "Depression during pregnancy has been linked to in utero stress and is associated with long-lasting symptoms in offspring, including anxiety, helplessness, attentional deficits, and social withdrawal." | 1.42 | Prenatal stress, regardless of concurrent escitalopram treatment, alters behavior and amygdala gene expression of adolescent female rats. ( Bourke, CH; Ehrlich, DE; Hazra, R; Jairam, N; Neigh, GN; Nemeth, CL; Owens, MJ; Rainnie, DG; Rowson, S; Ryan, SJ; Sholar, CA; Stowe, ZN, 2015) |
| "Neuropathic vulvodynia is a state of vulval discomfort characterized by a burning sensation, diffuse pain, pruritus or rawness with an acute or chronic onset." | 1.42 | A streptozotocin-induced diabetic neuropathic pain model for static or dynamic mechanical allodynia and vulvodynia: validation using topical and systemic gabapentin. ( Abbas, M; Ali, G; Sewell, RD; Shahid, M; Subhan, F; Zeb, J, 2015) |
| "OMT had analgesic effect on neuropathic pain, which might be probably related to HVDDCs." | 1.42 | [The Analgesia of Oxymatrine Affecting Calcium Channel and GABA Release]. ( Deng, YO; Liu, YG; Lu, XQ; Wu, SX; Yang, L, 2015) |
| "Here, we evaluated brain inflammation, synaptic protein expression, and adult hippocampal neurogenesis in the epileptogenic (1 and 2 months of age) and tonic-clonic (3." | 1.42 | Alterations in Brain Inflammation, Synaptic Proteins, and Adult Hippocampal Neurogenesis during Epileptogenesis in Mice Lacking Synapsin2. ( Ali, I; Bahonjic, E; Bakochi, A; Chugh, D; Ekdahl, CT; Etholm, L, 2015) |
| "Early-onset torsion dystonia (DYT1) is an autosomal-dominant movement disorder characterized by sustained muscle contractions and abnormal posturing." | 1.42 | Cerebellar synaptogenesis is compromised in mouse models of DYT1 dystonia. ( Bonsi, P; Maltese, M; Mandolesi, G; Pisani, A; Ponterio, G; Puglisi, F; Vanni, V, 2015) |
| "Mechanical allodynia in SNL rats was attenuated by gabapentin (100 mg/kg) and AQU-118 (in a dose-dependent manner)." | 1.42 | Effect of a Novel, Orally Active Matrix Metalloproteinase-2 and -9 Inhibitor in Spinal and Trigeminal Rat Models of Neuropathic Pain. ( Davis, SF; Fairchild, DD; Hain, HS; Hanania, T; Henry, MA; Hu, A; Malekiani, SA; Nix, D; Patil, MJ; Sucholeiki, I; Sucholeiki, R, 2015) |
| "The results of seizure scoring and histopathological findings in the hippocampus revealed a more pronounced response to the same administered TMT dose in juvenile mice, compared with that in adult mice." | 1.42 | Developmental and degenerative modulation of GABAergic transmission in the mouse hippocampus. ( Im, HI; Kang, S; Kim, J; Kim, JC; Kim, SH; Lee, S; Moon, C; Park, K; Shin, T; Son, Y; Takayama, C; Yang, M, 2015) |
| "Its sedative and anti-seizure effects (1, 10, 20, and 40 mg/kg) were evaluated in male mice." | 1.42 | Involvement of the GABAergic system in the neuroprotective and sedative effects of acacetin 7-O-glucoside in rodents. ( Almazán, S; Araujo, G; Benítez-King, G; Calixto, E; Estrada-Reyes, R; Fernández-Mas, R; Gálvez, J; Orozco, S, 2015) |
| "Depression was modelled by the olfactory bulbectomy (OBX) in Wistar male rats." | 1.42 | Reward related neurotransmitter changes in a model of depression: An in vivo microdialysis study. ( Amchova, P; Babinska, Z; Havlickova, T; Jerabek, P; Kacer, P; Ruda-Kucerova, J; Sulcova, A; Sustkova-Fiserova, M; Syslova, K, 2015) |
| "Mice were tested for tactile mechanical hyperalgesia at 1, 2, and 3 weeks following procedures." | 1.42 | Caffeine prevents antihyperalgesic effect of gabapentin in an animal model of CRPS-I: evidence for the involvement of spinal adenosine A1 receptor. ( Batisti, AP; Daruge-Neto, E; Emer, AA; Martins, DF; Mazzardo-Martins, L; Piovezan, AP; Prado, MR; Santos, AR, 2015) |
| "When this pathway is altered, seizures develop." | 1.42 | Toxoplasma gondii Infections Alter GABAergic Synapses and Signaling in the Central Nervous System. ( Blader, IJ; Brooks, JM; Carrillo, GL; Fox, MA; Lindsay, DS; Su, J, 2015) |
| "Depression is a complex neuropsychiatric syndrome that is often very severe and life threatening." | 1.40 | Dysfunctional glutamatergic and γ-aminobutyric acidergic activities in prefrontal cortex of mice in social defeat model of depression. ( Bagga, P; Chakravarty, S; Khandelwal, N; Kumar, A; Maitra, S; Noronha, JM; Patel, AB; Veeraiah, P, 2014) |
| "Gabapentin was converted by N-acylation at its N-terminus into di-, tri-, and tetrapeptides (L-Ala-Gbp, L-Val-Gbp, L-Ala-L-Phe-Gbp, Gly-L-Ala-β-Ala-Gbp)." | 1.40 | Gabapentin hybrid peptides and bioconjugates. ( Alamry, KA; Goncalves, K; Ibrahim, MA; Katritzky, AR; Lebedyeva, IO; Neubert, J; Ostrov, DA; Patel, K; Sileno, SM; Steel, PJ, 2014) |
| "Synthetic approaches to gabapentin bioconjugates that overcome the tendency of gabapentin to cyclize into its γ-lactam are studied." | 1.40 | Gabapentin hybrid peptides and bioconjugates. ( Alamry, KA; Goncalves, K; Ibrahim, MA; Katritzky, AR; Lebedyeva, IO; Neubert, J; Ostrov, DA; Patel, K; Sileno, SM; Steel, PJ, 2014) |
| " Time-course data for the dose-response effects were analyzed using two-way analysis of variance and the posthoc Tukey-Kramer multiple-comparison test." | 1.40 | Antinociceptive effects of mirtazapine, pregabalin, and gabapentin after chronic constriction injury of the infraorbital nerve in rats. ( Hashimoto, R; Hosokawa, K; Mashimo, T; Nakae, A; Nakai, K, 2014) |
| "Reserpine treatment significantly increased the immobility time in the forced swim test, which is indicative of depression in the animals." | 1.40 | The effects of Phα1β, a spider toxin, calcium channel blocker, in a mouse fibromyalgia model. ( Castro, CJ; da Costa Lopes, AM; da Silva, CA; da Silva, JF; de Souza, AH; Ferreira, J; Gomez, MV; Klein, CP; Pereira, EM, 2014) |
| "Gabapentin has shown to be effective in animals and humans with acute postoperative and chronic pain." | 1.40 | Gabapentin increases extracellular glutamatergic level in the locus coeruleus via astroglial glutamate transporter-dependent mechanisms. ( Eisenach, JC; Hayashida, K; Severino, AL; Suto, T, 2014) |
| "In this study, on a rat model of chronic pain, we determined how persistent pain altered behavioral responses to morphine reward measured by the paradigm of unbiased conditioned place preference (CPP), focusing on GABAergic synaptic activity in neurons of the central nucleus of the amygdala (CeA), an important brain region for emotional processing of both pain and reward." | 1.40 | Persistent pain facilitates response to morphine reward by downregulation of central amygdala GABAergic function. ( Hou, YY; Lu, YG; Pan, ZZ; Tao, W; Wang, W; Zhang, Z, 2014) |
| "Pregabalin reduced the percentage of seizures and increased the latency to seizure in the MES model in two parental mouse strains used to construct the mutants." | 1.40 | Anticonvulsant activity of pregabalin in the maximal electroshock-induced seizure assay in α2δ1 (R217A) and α2δ2 (R279A) mouse mutants. ( Donevan, S; Galvin, S; Hain, H; Lotarski, S; Offord, J; Peterson, J; Strenkowski, B, 2014) |
| "Tramadol was active against all four endpoints in the Chung model with similar effects in the CCI model, apart from tactile allodynia." | 1.40 | Face-to-face comparison of the predictive validity of two models of neuropathic pain in the rat: analgesic activity of pregabalin, tramadol and duloxetine. ( Castagné, V; Le Cudennec, C, 2014) |
| "The selected endpoints were tactile allodynia, tactile hyperalgesia, heat hyperalgesia and cold allodynia." | 1.40 | Face-to-face comparison of the predictive validity of two models of neuropathic pain in the rat: analgesic activity of pregabalin, tramadol and duloxetine. ( Castagné, V; Le Cudennec, C, 2014) |
| "Neuropathic pain is a chronic condition resulting from neuronal damage." | 1.40 | Silicon-containing GABA derivatives, silagaba compounds, as orally effective agents for treating neuropathic pain without central-nervous-system-related side effects. ( Amano, Y; Fukasawa, H; Ito, A; Muratake, H; Nagae, M; Shudo, K; Sugiyama, K; Suzuki, H, 2014) |
| " Noteworthy, the repeated administration of AT-RvD1 and RvD2 also prevented the depressive-like behavior in reserpine-treated animals, according to assessment of immobility time, although the chronic administration of pregabalin failed to affect this parameter." | 1.40 | Effects of D-series resolvins on behavioral and neurochemical changes in a fibromyalgia-like model in mice. ( Campos, MM; Klein, CP; Leite, CE; Maciel, IS; Souza, AH; Sperotto, ND, 2014) |
| "Rett syndrome is an autism-spectrum disorder resulting from mutations to the X-linked gene, methyl-CpG binding protein 2 (MeCP2), which causes abnormalities in many systems." | 1.40 | Alterations in the cholinergic system of brain stem neurons in a mouse model of Rett syndrome. ( Cui, N; Jiang, C; Johnson, CM; Oginsky, MF; Zhong, W, 2014) |
| "Diazepam was employed as standard anxiolytic drug." | 1.40 | Possible involvement of GABAergic and nitriergic systems for antianxiety-like activity of piperine in unstressed and stressed mice. ( Dhingra, D; Gilhotra, N, 2014) |
| "Gabapentin has been shown to disrupt the interaction of thrombospondin (TSP) with α2δ-1, an auxiliary calcium channel subunit." | 1.40 | Gabapentin attenuates hyperexcitability in the freeze-lesion model of developmental cortical malformation. ( Andresen, L; Dulla, CG; Hampton, D; Maguire, J; Morel, L; Taylor-Weiner, A; Yang, Y, 2014) |
| "Although mouse models of experimental autoimmune encephalomyelitis (EAE) have provided insight on the pathobiology of MS-induced neuropathic pain, concurrent severe motor impairments confound quantitative assessment of pain behaviors over the disease course." | 1.40 | Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods. ( Khan, N; Smith, MT; Woodruff, TM, 2014) |
| "Mechanical allodynia was fully developed by 28-30days post-immunization (p." | 1.40 | Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods. ( Khan, N; Smith, MT; Woodruff, TM, 2014) |
| "Spontaneous seizures occurred in at least 44% of animals 15-18 weeks after SE." | 1.40 | Persistent reduction of hippocampal glutamine synthetase expression after status epilepticus in immature rats. ( Bos, IW; de Graan, PN; Hessel, EV; Mulder, SD; van der Hel, WS; van Eijsden, P; Verlinde, SA, 2014) |
| "After establishment of neuropathic pain model with the lumbar 5 spinal nerve ligation (L5 SNL), the GABA-evoked currents were recorded in the acutely dissociated L4 DRG neurons using whole-cell patch clamp." | 1.40 | The role of the GABA-A receptor of the adjacent intact dorsal root ganglion neurons in rats with neuropathic pain. ( Fu, J; Gu, J; Gu, Y; Li, G; Ran, R; Wang, L; Wang, Q; Zhang, A; Zhao, Y; Zhong, H, 2014) |
| "Experimental preeclampsia was modeled by replacing the drinking water by 1." | 1.40 | [Comparative study of the effects of new neuroactive amino acid derivatives on the postnatal development of the rat's offspring with experimental preeclampsia]. ( Lebedeva, SA; Mikhailova, LI; Perfilova, VN; Tyurenkov, IN; Zhakupova, GA, 2014) |
| "It was found that the experimental preeclampsia causes a delay in physical development and maturation of sensory-motor reflexes in the offspring, as indicated by the later periods of eruption of the incisors and eye opening, response to the emergence of audio and olfactory stimuli, forming vestibular stability and coordination of movements compared to pups from females with physiological pregnancy." | 1.40 | [Comparative study of the effects of new neuroactive amino acid derivatives on the postnatal development of the rat's offspring with experimental preeclampsia]. ( Lebedeva, SA; Mikhailova, LI; Perfilova, VN; Tyurenkov, IN; Zhakupova, GA, 2014) |
| "Neuropathic pain is a debilitating condition that is often resistant to common analgesics, such as opioids, but is sensitive to some antidepressants, an effect that seems to be mediated by spinal cord 5-HT3 receptors." | 1.39 | The antinociceptive effect of reversible monoamine oxidase-A inhibitors in a mouse neuropathic pain model. ( Bonacorso, HG; Fachinetto, R; Ferreira, J; Machado, P; Martins, MA; Oliveira, SM; Pinheiro, Fde V; Pinheiro, Kde V; Villarinho, JG; Zanatta, N, 2013) |
| "While seizures are usually intractable to medication in tuberous sclerosis complex (TSC), a common genetic cause of epilepsy, vigabatrin appears to have unique efficacy for epilepsy in TSC." | 1.39 | Vigabatrin inhibits seizures and mTOR pathway activation in a mouse model of tuberous sclerosis complex. ( McDaniel, SS; Rensing, NR; Wong, M; Zhang, B, 2013) |
| "Although antiseizure medication is the first-line treatment for epilepsy, currently available medications are ineffective in a significant percentage of patients and have not clearly been demonstrated to have disease-specific effects for epilepsy." | 1.39 | Vigabatrin inhibits seizures and mTOR pathway activation in a mouse model of tuberous sclerosis complex. ( McDaniel, SS; Rensing, NR; Wong, M; Zhang, B, 2013) |
| "Amyloid-β (Aβ) plaque accumulation in Alzheimer's disease (AD) is associated with glutamatergic synapse loss, but less is known about its effect on inhibitory synapses." | 1.39 | Altered synapses and gliotransmission in Alzheimer's disease and AD model mice. ( Dickson, TC; Kirkcaldie, MT; Mitew, S; Vickers, JC, 2013) |
| "The selected neuropathic pain model was the spared nerve injury (SNI) model and the endpoints were burrowing and measures of paw posture in Sprague Dawley rats." | 1.39 | A back translation of pregabalin and carbamazepine against evoked and non-evoked endpoints in the rat spared nerve injury model of neuropathic pain. ( de Lannoy, IA; Dykstra, C; Higgins, GA; Lau, W; Lee, DK; Silenieks, LB; Thevarkunnel, S, 2013) |
| "Diabetes can exacerbate seizures and worsen seizure-related brain damage." | 1.39 | Pregabalin attenuates excitotoxicity in diabetes. ( Cheng, JT; Huang, CC; Huang, CW; Lai, MC; Tsai, JJ; Wu, SN, 2013) |
| "Diazepam-induced sleep was used for the evaluation of the sedative properties." | 1.39 | The anticonvulsant and sedative effects of Gladiolus dalenii extracts in mice. ( Moto, FC; Ngah, E; Ngo Bum, E; Ngoupaye, GT; Rakotonirina, A; Rakotonirina, SV; Taiwe, GS; Talla, E, 2013) |
| "Hypericum (H." | 1.39 | Anticonvulsant activity of Hypericum scabrum L.; possible mechanism involved. ( Ahangar, N; Ebrahimzadeh, MA; Nabavi, SF; Nabavi, SM, 2013) |
| "The model of insomnia rats were established by PCPA intraperitoneal injection, after the modeling, all the therapeutic group were treated with corresponding drug for one week." | 1.39 | [Effects of extracts from ziziphi spinosae semen and schisandrae chinensis fructus on amino acid neurotransmitter in rats with insomnia induced by PCPA]. ( Chen, JF; Gao, JR; Ji, WB; Jiang, H, 2013) |
| "Neuropathic pain is a chronic neurodegenerative disease." | 1.39 | Antinociceptive effect of Butea monosperma on vincristine-induced neuropathic pain model in rats. ( Krishnan, UM; Muthuraman, A; Shanmugam, P; Singh, N; Thiagarajan, VR, 2013) |
| "Major depression is a mental disorder often preceded by exposure to chronic stress or stressful life events." | 1.39 | Social vs. environmental stress models of depression from a behavioural and neurochemical approach. ( Elizalde, N; García-García, AL; Tordera, RM; Venzala, E, 2013) |
| "Although trigeminal neuropathic pain is one of the most common chronic pain syndromes, the etiology is still unknown." | 1.39 | Pre- and post-synaptic switches of GABA actions associated with Cl- homeostatic changes are induced in the spinal nucleus of the trigeminal nerve in a rat model of trigeminal neuropathic pain. ( Fukuda, A; Furukawa, T; Inoue, K; Kumada, T; Sato, K; Watanabe, M; Wei, B, 2013) |
| "Adenosine is an endogenous modulator of brain functions, which presents anticonvulsant properties." | 1.39 | Antiepileptic drugs prevent changes in adenosine deamination during acute seizure episodes in adult zebrafish. ( Bogo, MR; Bonan, CD; Nery, LR; Piato, AL; Schaefer, IC; Siebel, AM, 2013) |
| "co-treatment with ketamine and pregabalin at sub-effect low doses may be a useful therapeutic method for the treatment of neuropathic pain patients." | 1.39 | Intrathecal ketamine and pregabalin at sub-effective doses synergistically reduces neuropathic pain without motor dysfunction in mice. ( Choi, JG; Jeon, BH; Kim, HW; Kim, JM; Ko, YK; Lee, JH; Lim, HS; Park, JB; Shin, YS, 2013) |
| "pregabalin (10, 30, 100 µg) on mechanical allodynia and thermal hyperalgesia were measured." | 1.39 | Intrathecal ketamine and pregabalin at sub-effective doses synergistically reduces neuropathic pain without motor dysfunction in mice. ( Choi, JG; Jeon, BH; Kim, HW; Kim, JM; Ko, YK; Lee, JH; Lim, HS; Park, JB; Shin, YS, 2013) |
| "Thiopental sodium was intravenously administered in mice and sleeping time was measured." | 1.39 | Combined antiallodynic effect of Neurotropin® and pregabalin in rats with L5-spinal nerve ligation. ( Kawamura, M; Namba, H; Okai, H; Okazaki, R; Taguchi, K; Yoshida, H, 2013) |
| "It also antagonized strychnine induced seizures." | 1.38 | Antiepileptic activity of lobeline isolated from the leaf of Lobelia nicotianaefolia and its effect on brain GABA level in mice. ( Bodhankar, SL; Ghosh, P; Rub, RA; Tamboli, AM, 2012) |
| "A well-validated animal model of treatment resistant depression (congenital learned helpless rats = cLH) was investigated by hippocampal in vivo ¹H MRS with and without a 1-week course of electroconvulsive shocks (ECS), an animal model of ECT, and compared to wild type (WT) animals, while saline and clomipramine injections served as additional controls." | 1.38 | Increase of hippocampal glutamate after electroconvulsive treatment: a quantitative proton MR spectroscopy study at 9.4 T in an animal model of depression. ( Biedermann, S; Ende, G; Gass, P; Hoyer, C; Sartorius, A; Vollmayr, B; Weber-Fahr, W; Zheng, L, 2012) |
| "Tonic hind limb extension (seizure activity) was evoked in adult male albino Swiss mice by a current (sine-wave, 25 mA, 500 V, 50 Hz, 0." | 1.38 | Interactions of pregabalin with gabapentin, levetiracetam, tiagabine and vigabatrin in the mouse maximal electroshock-induced seizure model: a type II isobolographic analysis. ( Filip, D; Florek-Luszczki, M; Luszczki, JJ, 2012) |
| "Preclinical diagnosis of Alzheimer's disease is a major challenge." | 1.38 | Impaired glutamatergic and GABAergic function at early age in AβPPswe-PS1dE9 mice: implications for Alzheimer's disease. ( Patel, AB; Tiwari, V, 2012) |
| "NPC-treated animals showed decreased hyperalgesia and allodynia 1-3week post-transplantation; vehicle-injected CCI rats continued displaying pain behaviors." | 1.38 | Intraspinal transplantation of GABAergic neural progenitors attenuates neuropathic pain in rats: a pharmacologic and neurophysiological evaluation. ( Gajavelli, S; Hentall, ID; Jergova, S; Sagen, J; Varghese, MS, 2012) |
| "Gabapentin was used to provide an anxiolytic effect on drug-free days." | 1.38 | Evaluation of anxiolytic effect and withdrawal anxiety in chronic intermittent diazepam treatment in rats. ( Açikmeşe, B; Enginar, N; Hatipoğlu, I; Haznedar, S, 2012) |
| "This study evaluated the effect of intermittent administration in the development of dependence to diazepam in chronic use of the drug." | 1.38 | Evaluation of anxiolytic effect and withdrawal anxiety in chronic intermittent diazepam treatment in rats. ( Açikmeşe, B; Enginar, N; Hatipoğlu, I; Haznedar, S, 2012) |
| "Bacopa monnieri and Bacoside-A treatment reverses epilepsy associated changes to near control suggesting that decreased GABA receptors in the cerebral cortex have an important role in epileptic occurrence; Bacopa monnieri and Bacoside-A have therapeutic application in epilepsy management." | 1.38 | Decreased GABA receptor in the cerebral cortex of epileptic rats: effect of Bacopa monnieri and Bacoside-A. ( Abraham, PM; Antony, S; Balakrishnan, S; Mathew, J; Paulose, CS, 2012) |
| "In the renal cell carcinoma, in contrast with GBM, (13) C multiplets of γ-aminobutyric acid (GABA) differed from its precursor glutamate, suggesting that GABA did not derive from a common glutamate precursor pool." | 1.38 | Glucose metabolism via the pentose phosphate pathway, glycolysis and Krebs cycle in an orthotopic mouse model of human brain tumors. ( Bachoo, RM; Cho, SK; Choi, C; Deberardinis, RJ; Good, LB; Hatanpaa, KJ; Jindal, A; Kapur, P; Maher, EA; Malloy, CR; Marin-Valencia, I; Mashimo, T; Mickey, B; Pascual, JM; Raisanen, J; Rakheja, D; Sun, X; Takahashi, M; Togao, O; Vemireddy, V, 2012) |
| "Morphine was less potent in neuroma pain than in mechanical allodynia." | 1.38 | The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model. ( Miyazaki, R; Yamamoto, T, 2012) |
| "After TNT injury, mechanical allodynia and neuroma pain are observed." | 1.38 | The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model. ( Miyazaki, R; Yamamoto, T, 2012) |
| "It has been reported that <50% of neuropathic pain patients are satisfactorily treated with drugs." | 1.38 | The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model. ( Miyazaki, R; Yamamoto, T, 2012) |
| "The L5 spinal nerve ligation induced tactile allodynia, an increase of CD11b expression, and an increase in the protein expression level of the voltage-dependent Ca(2+) channel α(2)/δ-1 subunit in the spinal dorsal horn on the injured side." | 1.38 | Spinal mechanism underlying the antiallodynic effect of gabapentin studied in the mouse spinal nerve ligation model. ( Adachi-Akahane, S; Ito, M; Kuroda, M; Morimoto, S; Oda, S; Sugiyama, A, 2012) |
| "Gabapentin 400 μg attenuated mechanical hyperalgesia for 7 days compared with the control group." | 1.38 | Gabapentin augments the antihyperalgesic effects of diclofenac sodium through spinal action in a rat postoperative pain model. ( Imamachi, N; Narai, Y; Saito, Y, 2012) |
| " In APP/PS1 mice, a murine model of AD, at 8 months of age the cerebellum is devoid of fibrillar Aβ, but dosage of soluble Aβ(1-42), the form which is more prone to aggregation, showed higher levels in this structure than in the forebrain." | 1.38 | Excitability and synaptic alterations in the cerebellum of APP/PS1 mice. ( Boda, E; Hoxha, E; Montarolo, F; Parolisi, R; Tempia, F, 2012) |
| "Schizophrenia is a debilitating neurodevelopmental disorder affecting approximately 1% of the population and imposing a significant burden on society." | 1.38 | Modeling interneuron dysfunction in schizophrenia. ( Mirnics, K; Schmidt, MJ, 2012) |
| " As a corollary, they also show that long-term use of ETH and GAB is devoid of adverse behavioral and cognitive effects." | 1.38 | Lack of behavioral and cognitive effects of chronic ethosuximide and gabapentin treatment in the Ts65Dn mouse model of Down syndrome. ( Corrales, A; Flórez, J; García, S; Martínez, P; Martínez-Cué, C; Rueda, N; Sharma, A; Vidal, V, 2012) |
| "Gabapentin (GBP) is an anticonvulsant that acts at the α2δ-1 submit of the L-type calcium channel." | 1.38 | Gabapentin decreases epileptiform discharges in a chronic model of neocortical trauma. ( Barres, BA; Graber, KD; Jin, S; Li, H; McDonald, W; Prince, DA, 2012) |
| " These results indicate that chronic administration of GBP after cortical injury is antiepileptogenic in the undercut model of post-traumatic epilepsy, perhaps by both neuroprotective actions and decreases in excitatory synapse formation." | 1.38 | Gabapentin decreases epileptiform discharges in a chronic model of neocortical trauma. ( Barres, BA; Graber, KD; Jin, S; Li, H; McDonald, W; Prince, DA, 2012) |
| "Conversely, in painted turtle brain anoxia increases γ-amino butyric acid (GABA)ergic suppression of spontaneous electrical activity, and cell death is prevented." | 1.38 | Painted turtle cortex is resistant to an in vitro mimic of the ischemic mammalian penumbra. ( Buck, LT; Gu, XQ; Haddad, GG; Hogg, DW; Pamenter, ME, 2012) |
| "Linear regression analysis was used to evaluate the dose-response relationships between logarithms of drug doses and their resultant maximum possible antinociceptive effects in the mouse hot-plate test." | 1.38 | Synergistic interaction of pregabalin with the synthetic cannabinoid WIN 55,212-2 mesylate in the hot-plate test in mice: an isobolographic analysis. ( Florek-Łuszczki, M; Luszczki, JJ, 2012) |
| "When gabapentin and tramadol were used in combination, gabapentin had no additive antinociceptive effect except for 300 mg/kg in tail-flick and hot-plate tests." | 1.38 | The antinociceptive effects of systemic administration of tramadol, gabapentin and their combination on mice model of acute pain. ( Alaçam, B; Aydin, ON; Ek, RO; Şen, S; Temoçin, S; Uğur, B, 2012) |
| "The percentage allodynia relief was only 60% for carbamazepine and 80% for pregabalin by single administration, whereas their co-administration relieved allodynia by 100%." | 1.38 | Combined carbamazepine and pregabalin therapy in a rat model of neuropathic pain. ( Ahn, HJ; Choi, SJ; Gwak, MS; Hahm, TS; Kim, JK; Ryu, S; Yu, JM, 2012) |
| "Allodynia was determined using the von Frey hair test and dose-effect curves and isobolograms were used to investigate drug interactions." | 1.38 | Combined carbamazepine and pregabalin therapy in a rat model of neuropathic pain. ( Ahn, HJ; Choi, SJ; Gwak, MS; Hahm, TS; Kim, JK; Ryu, S; Yu, JM, 2012) |
| "Carbamazepine and pregabalin ameliorate neuropathic pain synergistically at higher doses." | 1.38 | Combined carbamazepine and pregabalin therapy in a rat model of neuropathic pain. ( Ahn, HJ; Choi, SJ; Gwak, MS; Hahm, TS; Kim, JK; Ryu, S; Yu, JM, 2012) |
| "Neuropathic pain was induced by L5 nerve ligation in Sprague-Dawley rats." | 1.38 | Combined carbamazepine and pregabalin therapy in a rat model of neuropathic pain. ( Ahn, HJ; Choi, SJ; Gwak, MS; Hahm, TS; Kim, JK; Ryu, S; Yu, JM, 2012) |
| "In ethidium bromide treated rats, gabapentin administered at 300 mg/kg increased cortical MDA by 66%." | 1.38 | The effect of gabapentin on oxidative stress in a model of toxic demyelination in rat brain. ( Abdel-Salam, OM; Khadrawy, YA; Mohammed, NA; Youness, ER, 2012) |
| "Acupuncture can effectively suppress insomnia induced down-regulation of hypothalamic GABA and GABA(A)R in rats and lengthen pole-climbing time, which may contribute to its effect in relieving insomnia." | 1.38 | [Effect of acupuncture at different acupoints on expression of hypothalamic GABA and GABA(A) receptor proteins in insomnia rats]. ( Gao, XY; Ren, S; Wang, PY; Zhou, YL, 2012) |
| "Moreover, animals with neuropathic pain showed significantly improved paw withdrawal thresholds (PWTs) following miR23b infusion." | 1.38 | Molecular targeting of NOX4 for neuropathic pain after traumatic injury of the spinal cord. ( Cho, HT; Choi, JI; Im, YB; Jee, MK; Kang, SK; Kwon, OH, 2012) |
| "Neuropathic pain is a well-known type of chronic pain caused by damage to the nervous system." | 1.38 | Molecular targeting of NOX4 for neuropathic pain after traumatic injury of the spinal cord. ( Cho, HT; Choi, JI; Im, YB; Jee, MK; Kang, SK; Kwon, OH, 2012) |
| "Angelman syndrome is a neurodevelopmental disorder caused by loss of function of the UBE3A gene encoding a ubiquitin E3 ligase." | 1.38 | Decreased tonic inhibition in cerebellar granule cells causes motor dysfunction in a mouse model of Angelman syndrome. ( Egawa, K; Fukuda, A; Inoue, K; Kishino, T; Kitagawa, K; Kitagawa, M; Saitoh, S; Takayama, C; Takayama, M, 2012) |
| "Behavioural assessments of tail muscle spasticity and mean arterial blood pressure responses to noxious somatic and/or visceral stimulation were used to test the effects of GBP on these abnormal reflexes." | 1.37 | Gabapentin for spasticity and autonomic dysreflexia after severe spinal cord injury. ( Duale, H; Kitzman, PH; Lyttle, TS; O'Dell, CR; Patel, SP; Rabchevsky, AG, 2011) |
| "Many drugs approved for neuropathic pain engage spinal noradrenergic and cholinergic systems for analgesia." | 1.37 | A tropomyosine receptor kinase inhibitor blocks spinal neuroplasticity essential for the anti-hypersensitivity effects of gabapentin and clonidine in rats with peripheral nerve injury. ( Eisenach, JC; Hayashida, K, 2011) |
| "Mechanical allodynia was assessed by measuring the forepaw withdrawal threshold to von Frey filaments, and cold allodynia was evaluated by measuring the time spent in lifting or licking the forepaw after applying acetone to it." | 1.37 | A novel rat forelimb model of neuropathic pain produced by partial injury of the median and ulnar nerves. ( Back, SK; Eun, JS; Kim, MA; Na, HS; Yi, H, 2011) |
| "Our rat forelimb model of neuropathic pain may be useful for studying human neuropathic pain and screening for valuable drug candidates." | 1.37 | A novel rat forelimb model of neuropathic pain produced by partial injury of the median and ulnar nerves. ( Back, SK; Eun, JS; Kim, MA; Na, HS; Yi, H, 2011) |
| "We have modified the method to a T10 spinal cord contusion model (SCC) of at-level central neuropathic pain in Sprague-Dawley rats." | 1.37 | Pregabalin attenuates place escape/avoidance behavior in a rat model of spinal cord injury. ( Baastrup, C; Finnerup, NB; Jensen, TS, 2011) |
| "Gabapentin failed to suppress the scratching behavior induced by the intradermal injection of compound 48/80 in normal mice." | 1.37 | Gabapentin and pregabalin inhibit the itch-associated response induced by the repeated application of oxazolone in mice. ( Manabe, H; Matsumoto, Y; Miura, H; Tsukumo, Y; Yano, H, 2011) |
| "Accordingly, we hypothesized that tactile allodynia post SCI is mediated by an upregulation of Ca(v)α2δ-1 in dorsal spinal cord." | 1.37 | Calcium channel alpha-2-delta-1 protein upregulation in dorsal spinal cord mediates spinal cord injury-induced neuropathic pain states. ( Boroujerdi, A; Kim, D; Luo, DZ; Sharp, K; Steward, O; Zeng, J, 2011) |
| "SCI-induced neuropathic pain can be manifested as both tactile allodynia (a painful sensation to a non-noxious stimulus) and hyperalgesia (an enhanced sensation to a painful stimulus)." | 1.37 | Calcium channel alpha-2-delta-1 protein upregulation in dorsal spinal cord mediates spinal cord injury-induced neuropathic pain states. ( Boroujerdi, A; Kim, D; Luo, DZ; Sharp, K; Steward, O; Zeng, J, 2011) |
| "Children who experience complex febrile seizures are at a higher risk of subsequent epileptic episodes, and they may require therapy." | 1.37 | Molecular alterations underlying epileptogenesis after prolonged febrile seizure and modulation by erythropoietin. ( Chu, K; Jeon, D; Jung, KH; Kang, KM; Kim, JH; Kim, M; Kim, S; Lee, SK; Lee, ST; Park, KI; Roh, JK, 2011) |
| "The antihyperalgesic effect of PBN on mechanical hyperalgesia was attenuated by intrathecal bicuculline, a GABA(A) receptor blocker." | 1.37 | Reactive oxygen species contribute to neuropathic pain by reducing spinal GABA release. ( Chung, JM; Chung, K; Kim, HK; Kim, HY; Lee, KY; Wang, J; Yowtak, J, 2011) |
| "Neuropathic pain was induced by a tight ligation of the L5 spinal nerve (SNL)." | 1.37 | Reactive oxygen species contribute to neuropathic pain by reducing spinal GABA release. ( Chung, JM; Chung, K; Kim, HK; Kim, HY; Lee, KY; Wang, J; Yowtak, J, 2011) |
| "Rett syndrome is a severe neurodevelopmental disease caused by mutations of the transcriptional repressor methyl-CpG-binding protein 2 (MeCP2) that induce complex, disabling symptoms, including breathing symptoms." | 1.37 | The benzodiazepine Midazolam mitigates the breathing defects of Mecp2-deficient mice. ( Hilaire, G; Voituron, N, 2011) |
| " In a long-term test, the antidepressant-like effect of MFP was better than that of GABA at the same dosage (2." | 1.37 | Antidepressant effect of GABA-rich monascus-fermented product on forced swimming rat model. ( Chuang, CY; Lo, YH; Pan, TM; Shi, YC; You, HP, 2011) |
| "Gabapentin is an anticonvulsant and adjuvant analgesic." | 1.37 | Chronic intrathecal infusion of gabapentin prevents nerve ligation-induced pain in rats. ( Chen, CC; Cheng, JK; Chu, LC; Hung, YC; Lin, CS; Tsaur, ML; Wang, TY, 2011) |
| "Electroconvulsions were produced in mice by means of an alternating current (50 Hz, 500 V, 25 mA, ear-clip electrodes, 0." | 1.37 | 7-Nitroindazole, but not NG-nitro-L-arginine, enhances the anticonvulsant activity of pregabalin in the mouse maximal electroshock-induced seizure model. ( Dworzański, W; Jaskólska, A; Zółkowska, D; Łuszczki, JJ, 2011) |
| "Diazepam effects were blocked by flumazenil." | 1.37 | Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord. ( Cardenas, R; Quintero, L; Suarez-Roca, H, 2011) |
| "FS stress enhanced formalin-induced hyperalgesia, increased pain-elicited c-Fos expression, decreased basal and delayed pain-induced GABA release, and increased basal and induced glutamate release." | 1.37 | Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord. ( Cardenas, R; Quintero, L; Suarez-Roca, H, 2011) |
| "Neuropathic pain is a clinical condition which remains poorly treated and combinations of pregabalin, an antagonist of the α2δ-subunit of Ca(2+) channels, with tapentadol, a μ-opioid receptor agonist/noradrenaline reuptake inhibitor, or with classical opioids such as oxycodone and morphine might offer increased therapeutic potential." | 1.37 | Synergistic antihypersensitive effects of pregabalin and tapentadol in a rat model of neuropathic pain. ( Christoph, T; De Vry, J; Schiene, K; Tallarida, RJ; Tzschentke, TM, 2011) |
| "Long-lasting hyperalgesia was induced in male Sprague Dawley rats with subcutaneous fentanyl (4 injections, 60 μg/kg per injection at 15-minute intervals) resulting in a total dose of 240 μg/kg." | 1.37 | The median effective dose of ketamine and gabapentin in opioid-induced hyperalgesia in rats: an isobolographic analysis of their interaction. ( Benhamou, D; Mazoit, JX; Sitbon, P; Van Elstraete, AC, 2011) |
| "We show that disease progression in the TgP347L rabbit closely tracks human cone-sparing RP, including the cone-associated preservation of bipolar cell signaling and triggering of reprogramming." | 1.37 | Retinal remodeling in the Tg P347L rabbit, a large-eye model of retinal degeneration. ( Anderson, J; Jones, BW; Kondo, M; Lin, Y; Marc, RE; Rapp, K; Shaw, MV; Terasaki, H; Watt, CB; Yang, JH, 2011) |
| " The results indicate that pretreatment with Parawixin 10 prevents the onset of seizures induced with kainic acid, N-methyl-D-aspartate, and pentylenetetrazole in a dose-response manner." | 1.37 | Neurobiological activity of Parawixin 10, a novel anticonvulsant compound isolated from Parawixia bistriata spider venom (Araneidae: Araneae). ( Beleboni, RO; Coutinho-Netto, J; Cunha, AO; dos Santos, WF; Fachim, HA; Gobbo-Neto, L; Lopes, NP; Pereira, AC, 2011) |
| "Pre-treatment with methylene blue enhanced the antianxiety effect of thymoquinone in both unstressed and stressed mice." | 1.37 | Thymoquinone produced antianxiety-like effects in mice through modulation of GABA and NO levels. ( Dhingra, D; Gilhotra, N, 2011) |
| "However, it is unclear whether the conductive hearing loss caused by otitis media in early age will affect sound tolerance later in life." | 1.37 | Early age conductive hearing loss causes audiogenic seizure and hyperacusis behavior. ( Allman, B; Fu, Q; Jayaram, A; Kumaraguru, A; Li, J; Manohar, S; Sun, W, 2011) |
| "Sepsis is a systemic immune response to infection that may result in multiple organ failure and death." | 1.37 | Sepsis-induced alterations in sleep of rats. ( Baracchi, F; Ingiosi, AM; Opp, MR; Raymond, RM, 2011) |
| "In rats with four ligatures, prominent mechanical allodynia and thermal hyperalgesia developed; these behavioral signs were not prominent in rats with two ligatures." | 1.37 | Pharmacological and behavioral characterization of the saphenous chronic constriction injury model of neuropathic pain in rats. ( Buldum, D; Gunduz, O; Guven, R; Oltulu, C; Ulugol, A, 2011) |
| "Then, behavioral signs of neuropathic pain were observed for 8 weeks." | 1.37 | Pharmacological and behavioral characterization of the saphenous chronic constriction injury model of neuropathic pain in rats. ( Buldum, D; Gunduz, O; Guven, R; Oltulu, C; Ulugol, A, 2011) |
| "Disk degeneration was induced by removal of the nucleus pulposus (NP) from the lumbar disks (L4/L5 and L5/L6) of Sprague Dawley rats using a 0." | 1.37 | The rat intervertebral disk degeneration pain model: relationships between biological and structural alterations and pain. ( An, HS; Buvanendran, A; Chen, D; Im, HJ; Kim, JS; Kroin, JS; Li, X; Tuman, KJ; van Wijnen, AJ; Yan, D, 2011) |
| "Because our seizure model is very severe, it is probable that this technique would have a robust effect in human focal epilepsy." | 1.36 | Optical suppression of experimental seizures in rat brain slices. ( Rode, DL; Rothman, SM; Schmidt, BF; Yang, XF, 2010) |
| "To evaluate the effects of high-frequency electrical stimulation (HFS) in both ventral hippocampi, alone and combined with a subeffective dose of antiepileptic drugs, during the status epilepticus (SE) induced by lithium-pilocarpine (LP)." | 1.36 | Antiepileptic drugs combined with high-frequency electrical stimulation in the ventral hippocampus modify pilocarpine-induced status epilepticus in rats. ( Alcantara-Gonzalez, D; Cuellar-Herrera, M; Neri-Bazan, L; Peña, F; Rocha, L, 2010) |
| " One minute following pilocarpine injection, HFS (pulses of 60 mus width at 130 Hz at subthreshold intensities and applied during 3 h) was applied alone or combined with subeffective doses of antiepileptic drugs." | 1.36 | Antiepileptic drugs combined with high-frequency electrical stimulation in the ventral hippocampus modify pilocarpine-induced status epilepticus in rats. ( Alcantara-Gonzalez, D; Cuellar-Herrera, M; Neri-Bazan, L; Peña, F; Rocha, L, 2010) |
| " This effect was not evident when HFS was combined with phenytoin (33." | 1.36 | Antiepileptic drugs combined with high-frequency electrical stimulation in the ventral hippocampus modify pilocarpine-induced status epilepticus in rats. ( Alcantara-Gonzalez, D; Cuellar-Herrera, M; Neri-Bazan, L; Peña, F; Rocha, L, 2010) |
| " In a chronic administration study, SHR were fed diets containing one of the tomato cultivars for 4 weeks." | 1.36 | Antihypertensive effect of a gamma-aminobutyric acid rich tomato cultivar 'DG03-9' in spontaneously hypertensive rats. ( Ezura, H; Fujii, T; Fukuda, N; Inai, S; Izumi, T; Konishi, C; Matsukura, C; Obata, A; Sano, A; Toyoshi, T; Yoshimura, M, 2010) |
| "Reversal of post-SCI neuropathic pain by tiagabine suggests that reduced GABAergic tone may contribute to hyperalgesia symptoms." | 1.36 | Loss of GABAergic interneurons in laminae I-III of the spinal cord dorsal horn contributes to reduced GABAergic tone and neuropathic pain after spinal cord injury. ( Marsh, AD; Marsh, DR; Meisner, JG, 2010) |
| "Current clinical treatments for neuropathic pain include amitriptyline, a tricyclic antidepressant with mixed pharmacology that is also clinically reported to impair cognitive performance; and gabapentin, a compound that selectively interacts with alpha2delta-1 calcium channel subunits." | 1.36 | Treatments for neuropathic pain differentially affect delayed matching accuracy by macaques: effects of amitriptyline and gabapentin. ( Arneric, SP; Buccafusco, JJ; Snutch, TP; Terry, AV; Vazdarjanova, A, 2010) |
| "The aim of this study was to characterize the anticonvulsant effects of 1-methyl-1,2,3,4-tetrahydroisoquinoline (MeTHIQ--an endogenous parkinsonism-preventing substance) in combination with four second-generation antiepileptic drugs (AEDs: lamotrigine [LTG], oxcarbazepine [OXC], pregabalin [PGB], and topiramate [TPM]) in the mouse maximal electroshock (MES)-induced seizure model by using the type I isobolographic analysis for parallel and non-parallel dose-response relationship curves (DRRCs)." | 1.36 | Interactions of 1-methyl-1,2,3,4-tetrahydroisoquinoline with lamotrigine, oxcarbazepine, pregabalin, and topiramate in the mouse maximal electroshock-induced seizure model: a type I isobolographic analysis. ( Antkiewicz-Michaluk, L; Czuczwar, SJ; Luszczki, JJ; Raszewski, G, 2010) |
| "Panic disorder is a severe anxiety disorder characterized by recurrent panic attacks that can be consistently provoked with intravenous (i." | 1.36 | Changes in central sodium and not osmolarity or lactate induce panic-like responses in a model of panic disorder. ( Dimicco, JA; Fitz, SD; Herman, JP; Johnson, PL; Molosh, AI; Shekhar, A, 2010) |
| "The cold allodynia was assessed by the tail immersion test (i." | 1.36 | Spinal GABA receptors mediate the suppressive effect of electroacupuncture on cold allodynia in rats. ( Go, DH; Han, JB; Kim, SK; Min, BI; Park, JH; Sun, B, 2010) |
| "Hyperalgesia is one of the debilitating complications of diabetes." | 1.36 | Diabetic thermal hyperalgesia: role of TRPV1 and CB1 receptors of periaqueductal gray. ( Ghazi-Khansari, M; Jaberi, E; Mohammadi-Farani, A; Sahebgharani, M; Sepehrizadeh, Z, 2010) |
| "Febrile seizures are the most common types of seizure in children, and are generally considered to be benign." | 1.36 | N-methyl-D-aspartate, hyperpolarization-activated cation current (Ih) and gamma-aminobutyric acid conductances govern the risk of epileptogenesis following febrile seizures in rat hippocampus. ( Awad, PN; Carmant, L; Di Cristo, G; Lema, P; Ouardouz, M, 2010) |
| "However, febrile seizures in children with dysgenesis have been associated with the development of temporal lobe epilepsy." | 1.36 | N-methyl-D-aspartate, hyperpolarization-activated cation current (Ih) and gamma-aminobutyric acid conductances govern the risk of epileptogenesis following febrile seizures in rat hippocampus. ( Awad, PN; Carmant, L; Di Cristo, G; Lema, P; Ouardouz, M, 2010) |
| "PTZ provoked clonic convulsions, reduced GABA content, deranged brain redox status, and elevated nitric oxide (NO)." | 1.36 | Magnesium supplementation enhances the anticonvulsant potential of valproate in pentylenetetrazol-treated rats. ( Abdallah, DM; Abdel-Aziz, MT; Arafa, NM; Safar, MM, 2010) |
| "To characterize the anticonvulsant effects of pregabalin (PGB - a third-generation antiepileptic drug) in combination with carbamazepine (CBZ - a classical antiepileptic drug) in the mouse maximal electroshock (MES)-induced seizure model by using the type I isobolographic analysis for non-parallel dose-response relationship curves (DRRCs)." | 1.36 | Interaction of pregabalin with carbamazepine in the mouse maximal electroshock-induced seizure model: a type I isobolographic analysis for non-parallel dose-response relationship curves. ( Luszczki, JJ, 2010) |
| "Tonic hind limb extension (seizure activity) was evoked in adult male albino Swiss mice by a current (sine-wave, 25mA, 500V, 50Hz, 0." | 1.36 | Interaction of pregabalin with carbamazepine in the mouse maximal electroshock-induced seizure model: a type I isobolographic analysis for non-parallel dose-response relationship curves. ( Luszczki, JJ, 2010) |
| "Our findings demonstrated that seizures induced by (PhSe)₂ are mediated, at least in part, by an interaction with GABAergic system." | 1.36 | Diphenyl diselenide-induced seizures in rat pups: possible interaction with GABAergic system. ( Nogueira, CW; Prigol, M; Wilhelm, EA; Zeni, G, 2010) |
| "We have generated a FTLD-U mouse model (CaMKII-TDP-43 Tg) in which TDP-43 is transgenically overexpressed in the forebrain resulting in phenotypic characteristics mimicking those of FTLD-U." | 1.36 | Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U. ( Chien, WL; Cho, KH; Fang, YH; Fu, WM; Lin, CP; Shen, CK; Tsai, KJ; Wang, WT; Wu, TW; Yang, CH, 2010) |
| "Mechanical hyperalgesia was fully reversed by three analgesic drugs used in treating neuropathic SCI pain, but their duration of action differed significantly, showing a rank order of amitriptyline (24-48 h)≫morphine (6 h)>gabapentin (2 h)." | 1.36 | Above-level mechanical hyperalgesia in rats develops after incomplete spinal cord injury but not after cord transection, and is reversed by amitriptyline, morphine and gabapentin. ( Densmore, VS; Kalous, A; Keast, JR; Osborne, PB, 2010) |
| ", lamotrigine [LTG], oxcarbazepine [OXC] and topiramate [TPM]) in the mouse maximal electroshock (MES)-induced seizure model by using the type I isobolographic analysis for non-parallel dose-response relationship curves (DRRCs)." | 1.36 | Additive interactions of pregabalin with lamotrigine, oxcarbazepine and topiramate in the mouse maximal electroshock-induced seizure model: a type I isobolographic analysis for non-parallel dose-response relationship curves. ( Czuczwar, SJ; Filip, D; Luszczki, JJ, 2010) |
| "Tonic hind limb extension (seizure activity) was evoked in adult male albino Swiss mice by a current (sine-wave, 25mA, 500V, 50Hz, 0." | 1.36 | Additive interactions of pregabalin with lamotrigine, oxcarbazepine and topiramate in the mouse maximal electroshock-induced seizure model: a type I isobolographic analysis for non-parallel dose-response relationship curves. ( Czuczwar, SJ; Filip, D; Luszczki, JJ, 2010) |
| "Gabapentin and clonidine were concomitantly administered in a fixed-dose ratio proportional to the predetermined ED(50) of these drugs, thereby obtaining a dose-response curve for the drug combination and its ED(50)." | 1.36 | Intrathecal gabapentin and clonidine synergistically inhibit allodynia in spinal nerve-ligated rats. ( Asada, A; Funao, T; Mori, T; Nishikawa, K; Yamama, Y, 2010) |
| " After confirmation of the established allodynia, gabapentin at 10, 30, 60 and 100μg or clonidine at 5, 15, 30 and 50μg was injected as a monotherapy in conscious rats through the intrathecal catheter to obtain the dose-response curve of %MPE (maximum possible effect) of the antiallodynic effect and its ED(50)." | 1.36 | Intrathecal gabapentin and clonidine synergistically inhibit allodynia in spinal nerve-ligated rats. ( Asada, A; Funao, T; Mori, T; Nishikawa, K; Yamama, Y, 2010) |
| " Single, parenteral dosing of donepezil (1, 1." | 1.36 | Low dose of donepezil improves gabapentin analgesia in the rat spared nerve injury model of neuropathic pain: single and multiple dosing studies. ( Andersen, LM; Bjerrum, OJ; Folkesson, A; Honoré, PH; Kristensen, P, 2010) |
| "Muscimol was effective in reducing AEP in both LA and HA rats." | 1.36 | GABAergic regulation of auditory sensory gating in low- and high-anxiety rats submitted to a fear conditioning procedure. ( Brandão, ML; Cabral, A; Nobre, MJ, 2010) |
| "Stroke is a leading cause of disability, but no pharmacological therapy is currently available for promoting recovery." | 1.36 | Reducing excessive GABA-mediated tonic inhibition promotes functional recovery after stroke. ( Carmichael, ST; Clarkson, AN; Huang, BS; Macisaac, SE; Mody, I, 2010) |
| "Rett syndrome is characterized by apparently normal early development followed by regression, motor abnormalities, seizures and features of autism, especially stereotyped behaviours." | 1.36 | Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes. ( Chahrour, M; Chao, HT; Chen, H; Ekker, M; Gong, S; Heintz, N; Lu, HC; Neul, JL; Noebels, JL; Rosenmund, C; Rubenstein, JL; Samaco, RC; Xue, M; Yoo, J; Zoghbi, HY, 2010) |
| " The PWT in PSL mice was dose-dependently increased by intraperitoneal injection of gabapentin, but the anti-allodynic effects varied according to its dosing time." | 1.36 | Molecular basis for the dosing time-dependency of anti-allodynic effects of gabapentin in a mouse model of neuropathic pain. ( Hamamura, K; Inoue, K; Koyanagi, S; Kusunose, N; Matsunaga, N; Ohdo, S; Tsuda, M; Uchida, T; Yoshida, M, 2010) |
| "These findings suggest that the dosing time-dependent difference in the anti-allodynic effects of gabapentin is attributable to the circadian oscillation of α2δ-1 subunit expression in the DRG and indicate that the optimizing its dosing schedule helps to achieve rational pharmacotherapy for neuropathic pain." | 1.36 | Molecular basis for the dosing time-dependency of anti-allodynic effects of gabapentin in a mouse model of neuropathic pain. ( Hamamura, K; Inoue, K; Koyanagi, S; Kusunose, N; Matsunaga, N; Ohdo, S; Tsuda, M; Uchida, T; Yoshida, M, 2010) |
| "Neuropathic pain is characterized by hypersensitivity to innocuous stimuli (tactile allodynia) that is nearly always resistant to NSAIDs or even opioids." | 1.36 | Molecular basis for the dosing time-dependency of anti-allodynic effects of gabapentin in a mouse model of neuropathic pain. ( Hamamura, K; Inoue, K; Koyanagi, S; Kusunose, N; Matsunaga, N; Ohdo, S; Tsuda, M; Uchida, T; Yoshida, M, 2010) |
| "Fragile X syndrome is caused by the functional loss of the fragile X mental retardation 1 (FMR1) gene." | 1.35 | Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila. ( Bray, SM; Chang, S; He, C; Jin, P; Li, Z; Warren, ST; Zarnescu, DC, 2008) |
| "CCI also evoked mechanical allodynia that was fully developed on a week post-operation, but showed no recovery for at least 8 weeks." | 1.35 | Pharmacological characteristics of the hind paw weight bearing difference induced by chronic constriction injury of the sciatic nerve in rats. ( Kurebayashi, Y; Nakazato-Imasato, E, 2009) |
| "Gabapentin is a structural analog of GABA that has anticonvulsant properties." | 1.35 | Cellular and behavioral interactions of gabapentin with alcohol dependence. ( Cruz, MT; Gilpin, NW; Koob, GF; Morse, AC; O'Dell, LE; Roberto, M; Siggins, GR, 2008) |
| "Gabapentin effects were blocked in the presence of a specific GABA(B) receptor antagonist." | 1.35 | Cellular and behavioral interactions of gabapentin with alcohol dependence. ( Cruz, MT; Gilpin, NW; Koob, GF; Morse, AC; O'Dell, LE; Roberto, M; Siggins, GR, 2008) |
| "In both neuropathic pain models, rats exhibited mechanical hypersensitivity, whereas a significant increase in anxiety-like behaviour was observed only in CCI rats (time spent in open arms decreased significantly from 99+/-15." | 1.35 | Anxiety-like behaviour in rats with mononeuropathy is reduced by the analgesic drugs morphine and gabapentin. ( Arndt, K; Ceci, A; Doods, H; Roeska, K; Treede, RD, 2008) |
| "Neuropathic pain was induced in rats by partial sciatic nerve ligation (PNL) and chronic constriction injury (CCI)." | 1.35 | Anxiety-like behaviour in rats with mononeuropathy is reduced by the analgesic drugs morphine and gabapentin. ( Arndt, K; Ceci, A; Doods, H; Roeska, K; Treede, RD, 2008) |
| "After global cerebral ischemia, delayed cell death is observed in the thalamic reticular nucleus but the mechanisms involved are not well described." | 1.35 | Endonuclease G expression in thalamic reticular nucleus after global cerebral ischemia. ( Diemer, NH; Nielsen, M; Zimmer, J, 2008) |
| "Epilepsy is a serious neurological disorder in human beings and the long-term pathological events remain largely obscure." | 1.35 | Time-course of neuronal death in the mouse pilocarpine model of chronic epilepsy using Fluoro-Jade C staining. ( Chen, LW; Huang, YG; Liu, YH; Wang, L, 2008) |
| "In the maximal electroshock seizure threshold test, electroconvulsions were produced by a current with various intensities whilst in the pentylenetetrazole test a CD(97) dose (100 mg/kg) was used." | 1.35 | Isobolographic and behavioral characterizations of interactions between vigabatrin and gabapentin in two experimental models of epilepsy. ( Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N, 2008) |
| " However, the dose-response curve significantly shifted toward lower concentration values in G93A motor neurons and the extent of desensitization also increased in these neurons." | 1.35 | GAB(A) receptors present higher affinity and modified subunit composition in spinal motor neurons from a genetic model of amyotrophic lateral sclerosis. ( Carunchio, I; Merlo, D; Mollinari, C; Pieri, M; Zona, C, 2008) |
| "Hyperalgesia was no less prevalent or severe after partial than after total axotomy." | 1.35 | Effects of distal nerve injuries on dorsal-horn neurons and glia: relationships between lesion size and mechanical hyperalgesia. ( Lee, JW; Oaklander, AL; Siegel, SM, 2009) |
| "In human patients, cortical dysplasia produced by Doublecortin (DCX) mutations lead to mental retardation and intractable infantile epilepsies, but the underlying mechanisms are not known." | 1.35 | Abnormal network activity in a targeted genetic model of human double cortex. ( Ackman, JB; Aniksztejn, L; Becq, H; Ben-Ari, Y; Cardoso, C; Crépel, V; Pellegrino, C; Represa, A, 2009) |
| " In contrast, levetiracetam was without affect on tiagabine or vigabatrin concentrations and co-administration with gabapentin, tiagabine or vigabatrin had no effect on levetiracetam brain concentrations, indicating the pharmacodynamic nature of interaction between these antiepileptic drugs in the mouse pentylenetetrazole model." | 1.35 | Pharmacodynamic and pharmacokinetic interaction profiles of levetiracetam in combination with gabapentin, tiagabine and vigabatrin in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis. ( Andres-Mach, MM; Czuczwar, SJ; Dudra-Jastrzebska, M; Luszczki, JJ; Patsalos, PN; Ratnaraj, N; Sielski, M, 2009) |
| " Measurement of total brain antiepileptic drug concentrations revealed that levetiracetam in combination with gabapentin at the fixed-ratio of 1:4 significantly elevated (21%) total brain gabapentin concentrations." | 1.35 | Pharmacodynamic and pharmacokinetic interaction profiles of levetiracetam in combination with gabapentin, tiagabine and vigabatrin in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis. ( Andres-Mach, MM; Czuczwar, SJ; Dudra-Jastrzebska, M; Luszczki, JJ; Patsalos, PN; Ratnaraj, N; Sielski, M, 2009) |
| "Clonic seizures were evoked in Albino Swiss mice by subcutaneous injection of pentylenetetrazole at its CD(97)(98 mg/kg)." | 1.35 | Pharmacodynamic and pharmacokinetic interaction profiles of levetiracetam in combination with gabapentin, tiagabine and vigabatrin in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis. ( Andres-Mach, MM; Czuczwar, SJ; Dudra-Jastrzebska, M; Luszczki, JJ; Patsalos, PN; Ratnaraj, N; Sielski, M, 2009) |
| "To observe yin deficiency model mice anxiety action by means of the elevated plus-maze and light-dark transitions of mice." | 1.35 | [Effects of Semen Ziziphi Spinosae on the anxiety behavior of the yin deficiency mice]. ( Cui, Y; Dai, YX; Rong, CL, 2008) |
| "(1) Compared with yin deficiency model group, Tabellae Diazepami group and the middle alcohol extracts group increased instinctively in the percentage of time and degree entering open-arm in eleveated plus maze, and the passing times in light-dark transitions increased instinctively (P<0." | 1.35 | [Effects of Semen Ziziphi Spinosae on the anxiety behavior of the yin deficiency mice]. ( Cui, Y; Dai, YX; Rong, CL, 2008) |
| "Neuropathic pain was induced in male Sprague-Dawley rats by a surgical ligation of left L5 nerve." | 1.35 | Protective effects of gabapentin on allodynia and alpha 2 delta 1-subunit of voltage-dependent calcium channel in spinal nerve-ligated rats. ( Ahn, HJ; Bae, CD; Cho, HS; Choi, SJ; Gwak, MS; Hahm, TS; Kim, HS; Kim, JA; Lee, SM; Lim, SW; Sim, WS, 2009) |
| "After training, cerebral ischemia was induced by MCAO for 120 min, followed by reperfusion." | 1.35 | Pre-ischemic treadmill training affects glutamate and gamma aminobutyric acid levels in the striatal dialysate of a rat model of cerebral ischemia. ( Cao, ZJ; Hu, YS; Jia, J; Liu, G; Wu, Y; Xia, CM; Yu, HX; Zheng, QP; Zhu, DN, 2009) |
| "Valproic acid (VPA) has been used for many years as a drug of choice for epilepsy and mood disorders." | 1.35 | Chronic dietary administration of valproic acid protects neurons of the rat nucleus basalis magnocellularis from ibotenic acid neurotoxicity. ( Brignani, S; Contestabile, A; Eleuteri, S; Monti, B, 2009) |
| " Here we determined the antinociceptive effect of chronic administration of neramexane and compared its effect with that of memantine and gabapentin in a rat model of diabetic neuropathic pain." | 1.35 | Antinociceptive effects of chronic administration of uncompetitive NMDA receptor antagonists in a rat model of diabetic neuropathic pain. ( Chen, SR; Pan, HL; Samoriski, G, 2009) |
| "gabapentin was studied by isobolographic analysis." | 1.35 | Antinociceptive effects of NCX-701 (nitro-paracetamol) in neuropathic rats: enhancement of antinociception by co-administration with gabapentin. ( Curros-Criado, MM; Herrero, JF, 2009) |
| "Neuropathic pain is characterized by a poor response to classic analgesics." | 1.35 | Antinociceptive effects of NCX-701 (nitro-paracetamol) in neuropathic rats: enhancement of antinociception by co-administration with gabapentin. ( Curros-Criado, MM; Herrero, JF, 2009) |
| "Osteoarthritis was induced via intra-articular injection of monosodium iodoacetate (MIA) into the knee joint." | 1.35 | Descending serotonergic facilitation and the antinociceptive effects of pregabalin in a rat model of osteoarthritic pain. ( Bannister, K; Bauer, CS; Dickenson, AH; Dolphin, AC; Rahman, W; Vonsy, JL, 2009) |
| "No causal treatment of ataxias is available at the moment, and so symptomatic and disease-modifying therapies are regarded as a reliable possibility for this complex group of movement disorders." | 1.35 | Gabapentin treatment improves motor coordination in a mice model of progressive ataxia. ( Calzà, L; D'Intino, G; Ferraro, L; Giardino, L; Gusciglio, M; Massella, A; Sivilia, S, 2009) |
| " For this purpose we conducted a dose-response study at concentrations of AMPA between 0." | 1.35 | Pattern of injury with a graded excitotoxic insult and ensuing chronic medial septal damage in the rat brain. ( Andrés, N; Batlle, M; Mahy, N; Malpesa, Y; Prats, A; Pugliese, M; Rodríguez, MJ, 2009) |
| "Vgx rats showed sustained hyperalgesia in the gastrocnemius muscle without tissue damage (no increase in vgx-induced plasma creatine phosphokinase or lactose dehydrogenase levels) accompanied by hypersensitivity to colonic distension." | 1.35 | Subdiaphragmatic vagotomy promotes nociceptive sensitivity of deep tissue in rats. ( Furuta, S; Horie, S; Kuzumaki, N; Matsumoto, K; Narita, M; Shimizu, T; Suzuki, T, 2009) |
| " In the present retrospective study we evaluated the impact of these vendor changes on ketamine dosing to establish anaesthesia, on pilocarpine-induced seizure susceptibility, and on basal extracellular hippocampal noradrenaline, dopamine, serotonin, gamma-amino butyric acid, and glutamate levels of all pilocarpine-treated rats included in our studies." | 1.35 | Intrastrain differences in seizure susceptibility, pharmacological response and basal neurochemistry of Wistar rats. ( Aourz, N; Clinckers, R; De Bundel, D; Meurs, A; Michotte, Y; Portelli, J; Smolders, I, 2009) |
| "Pretreatment with bumetanide (0." | 1.35 | Age- and dose-specific anticonvulsant action of bumetanide in immature rats. ( Mares, P, 2009) |
| "Bumetanide is a specific inhibitor of this cotransporter." | 1.35 | Age- and dose-specific anticonvulsant action of bumetanide in immature rats. ( Mares, P, 2009) |
| "Visceral pain is one of the most common forms of pain and for which new drugs would be welcome." | 1.35 | Gabapentin action and interaction on the antinociceptive effect of morphine on visceral pain in mice. ( Meymandi, MS; Sepehri, G, 2008) |
| "Inhibition of the allodynia with receptor antagonists indicated that each agent induces allodynia by a distinct mechanism." | 1.35 | Transient allodynia pain models in mice for early assessment of analgesic activity. ( Cheevers, CV; Donello, JE; Gil, DW, 2008) |
| "These transient allodynia models are a useful addition to the toolbox of preclinical pain models." | 1.35 | Transient allodynia pain models in mice for early assessment of analgesic activity. ( Cheevers, CV; Donello, JE; Gil, DW, 2008) |
| " Chronic administration of haloperidol (1 mg/kg, i." | 1.35 | Progesterone attenuates neuroleptic-induced orofacial dyskinesia via the activity of its metabolite, allopregnanolone, a positive GABA(A) modulating neurosteroid. ( Bishnoi, M; Chopra, K; Kulkarni, SK, 2008) |
| "Rett syndrome is a neurodevelopmental disorder caused by mutations in the transcriptional repressor methyl-CpG-binding protein 2 (MeCP2) and represents the leading genetic cause for mental retardation in girls." | 1.35 | Early defects of GABAergic synapses in the brain stem of a MeCP2 mouse model of Rett syndrome. ( Aramuni, G; Dudanova, I; Medrihan, L; Missler, M; Sargsyan, V; Tantalaki, E; Zhang, W, 2008) |
| "Seizures were evoked in freely moving rats by intrahippocampal microperfusion, via a microdialysis probe, of the muscarinic receptor agonist pilocarpine (10mM), GABA(A) receptor antagonist picrotoxin (100microM) or group I metabotropic glutamate receptor agonist (R,S)-3,5-dihydroxyphenylglycine (DHPG) (1mM)." | 1.35 | Seizure activity and changes in hippocampal extracellular glutamate, GABA, dopamine and serotonin. ( Clinckers, R; Ebinger, G; Meurs, A; Michotte, Y; Smolders, I, 2008) |
| "During seizures, hippocampal glutamate, GABA and dopamine concentrations increased in all groups." | 1.35 | Seizure activity and changes in hippocampal extracellular glutamate, GABA, dopamine and serotonin. ( Clinckers, R; Ebinger, G; Meurs, A; Michotte, Y; Smolders, I, 2008) |
| "Inhibition of herpetic allodynia by repeated oral administration of gabapentin (100 mg/kg) alleviated the overexpression of mRNA of pronociceptin, as well as the severity of postherpetic allodynia." | 1.35 | Nociceptin-receptor deficiency prevents postherpetic pain without effects on acute herpetic pain in mice. ( Andoh, T; Kuraishi, Y; Sasaki, A; Shiraki, K; Takahata, H; Takasaki, I; Takeshima, H, 2008) |
| "Pelvic pain was detected 5 days after antigen instillation and was sustained beyond 30 days, indicating the development of chronic pain." | 1.35 | Experimental autoimmune prostatitis induces chronic pelvic pain. ( Rudick, CN; Schaeffer, AJ; Thumbikat, P, 2008) |
| "Acute seizure activity was behaviorally scored and hemispheric brain atrophy measured." | 1.35 | Gabapentin neuroprotection and seizure suppression in immature mouse brain ischemia. ( Comi, AM; Johnston, MV; Kadam, SD; Mulholland, JD; Traa, BS, 2008) |
| "Nicotine has a protective effect on the dopaminergic neurons in the MPTP-treated mice." | 1.34 | [The protective effect of nicotine on dopaminergic neuron of Parkinson's disease mice]. ( Feng, YH; Li, Y; Peng, Y; Sun, YP; Yu, DQ; Zhang, DM; Zhang, WQ; Zhao, J, 2007) |
| "Nicotine was given for 10 days in the pretreatment group." | 1.34 | [The protective effect of nicotine on dopaminergic neuron of Parkinson's disease mice]. ( Feng, YH; Li, Y; Peng, Y; Sun, YP; Yu, DQ; Zhang, DM; Zhang, WQ; Zhao, J, 2007) |
| " We used a repeated dosing paradigm because there are precedents showing that repeated drug exposure may be necessary to demonstrate analgesia in neuropathic pain models." | 1.34 | Chemotherapy-evoked painful peripheral neuropathy: analgesic effects of gabapentin and effects on expression of the alpha-2-delta type-1 calcium channel subunit. ( Bennett, GJ; Boroujerdi, A; Luo, ZD; Xiao, W, 2007) |
| "Muscle hyperalgesia (withdrawal threshold to compression of the muscle) and cutaneous hyperalgesia of the paw (withdrawal threshold to von Frey filaments) were measured before and after induction of hyperalgesia and after treatment with pregabalin (saline, 10 to 100 mg/kg i." | 1.34 | Pregabalin reduces muscle and cutaneous hyperalgesia in two models of chronic muscle pain in rats. ( Audette, KM; Maeda, Y; Sluka, KA; Yokoyama, T, 2007) |
| " Pregabalin was administered either intraperitoneally (IP) or intrathecally (IT) and dosed up incrementally until an antiallodynic effect without sedation or motor impairment was apparent." | 1.34 | Antiallodynic effect of pregabalin in rat models of sympathetically maintained and sympathetic independent neuropathic pain. ( Han, DW; Kweon, TD; Lee, JS; Lee, YW, 2007) |
| "Neuropathic pain has both sympathetically maintained pain (SMP) and sympathetic independent pain (SIP) components." | 1.34 | Antiallodynic effect of pregabalin in rat models of sympathetically maintained and sympathetic independent neuropathic pain. ( Han, DW; Kweon, TD; Lee, JS; Lee, YW, 2007) |
| "After 5 days of GBP infusion, seizures were induced by flurothyl dripped onto filter paper." | 1.34 | Intraventricular administration of gabapentin in the rat increases flurothyl seizure threshold. ( Fisher, RS; Kraus, AC; Oommen, J, 2007) |
| "First tonic-clonic seizure was at 295." | 1.34 | Intraventricular administration of gabapentin in the rat increases flurothyl seizure threshold. ( Fisher, RS; Kraus, AC; Oommen, J, 2007) |
| "Time to first myoclonic or partial seizure was not influenced." | 1.34 | Intraventricular administration of gabapentin in the rat increases flurothyl seizure threshold. ( Fisher, RS; Kraus, AC; Oommen, J, 2007) |
| "Animal models of neuropathic pain have enabled the identification of key pathophysiological changes occurring within nociceptive pathways as a result of injury, and serve an invaluable role for preclinical screening of novel analgesic candidates." | 1.34 | The importance of genetic background on pain behaviours and pharmacological sensitivity in the rat spared serve injury model of peripheral neuropathic pain. ( Bjerrum, OJ; Blackburn-Munro, G; Broløs, T; Jensen, DG; Rode, F; Thomsen, M, 2007) |
| "While the rat was behaving freely, a seizure-inducing concentration of acetylcholine (Ach) was applied into the cup." | 1.34 | Transmeningeal delivery of GABA to control neocortical seizures in rats. ( Baptiste, SL; Devinsky, O; John, JE; Kuzniecky, RI; Ludvig, N; Sheffield, LG; von Gizycki, H, 2007) |
| "Drugs that are effective in treating the manic phase of bipolar disorder (lithium, carbamazepine, and valproate) upon chronic administration to rats decrease the turnover of arachidonic acid in their brain phospholipids." | 1.34 | Chronic lamotrigine does not alter the turnover of arachidonic acid within brain phospholipids of the unanesthetized rat: implications for the treatment of bipolar disorder. ( Bazinet, RP; Chang, L; Lee, HJ; Rao, JS; Rapoport, SI, 2007) |
| "Metabolic syndrome is characterized by obesity, elevated blood pressure (BP), insulin resistance, and hypercholesterolemia." | 1.34 | Upregulation of GAD65 mRNA in the medulla of the rat model of metabolic syndrome. ( Akil, H; Britton, SL; Buck, BJ; Burghardt, PR; Kerman, IA; Koch, LG; Watson, SJ, 2007) |
| "Vigabatrin was used with the aim of enhancing GABAergic neurotransmission, and in this way to investigate the role of this process in the properties of SWDs." | 1.34 | GABAergic mechanisms in absence epilepsy: a computational model of absence epilepsy simulating spike and wave discharges after vigabatrin in WAG/Rij rats. ( Bouwman, BM; Lopes da Silva, FH; Maris, E; Suffczynski, P; van Rijn, CM, 2007) |
| "The theory of depression is dominated by the monoamine hypothesis but there is increasing evidence that beyond monoamines, glutamate (Glu) and gamma-aminobutyric acid (GABA) play an essential role in the pathogenesis of depression." | 1.34 | Elevated spectroscopic glutamate/gamma-amino butyric acid in rats bred for learned helplessness. ( Ende, G; Henn, FA; Mahlstedt, MM; Sartorius, A; Vollmayr, B, 2007) |
| "Both spastic behavior and electromyography (EMG) activity were significantly decreased at 1 and 3 h post-GBP injection when compared with the activity level following administration of saline." | 1.34 | Gabapentin suppresses spasticity in the spinal cord-injured rat. ( Dwyer, MK; Kitzman, PH; Uhl, TL, 2007) |
| "Infantile Neuronal Ceroid Lipofuscinosis (INCL) results from mutations in the palmitoyl protein thioesterase (PPT1, CLN1) gene and is characterized by dramatic death of cortical neurons." | 1.33 | Mice with Ppt1Deltaex4 mutation replicate the INCL phenotype and show an inflammation-associated loss of interneurons. ( Fabritius, AL; Gentile, M; Jalanko, A; Kopra, O; Manninen, T; Minye, H; Peltonen, L; Rapola, J; Salonen, T; Vesa, J; von Schantz, C, 2005) |
| "01) difference when the highest dosage of the drug was administered." | 1.33 | Oral treatment with PD-0200347, an alpha2delta ligand, reduces the development of experimental osteoarthritis by inhibiting metalloproteinases and inducible nitric oxide synthase gene expression and synthesis in cartilage chondrocytes. ( Boileau, C; Boily, M; Brunet, J; El-Kattan, A; Flory, C; Martel-Pelletier, J; Pelletier, JP; Schrier, D; Tardif, G, 2005) |
| " These results present a novel interpretation of synergistic inhibition of certain epileptic discharges using vigabatrin and another drug, and that for successful synergistic treatment of epilepsies carefully designed timed dosage regimens are essential." | 1.33 | Antiepileptic action induced by a combination of vigabatrin and tiagabine. ( Fueta, Y; Kunugita, N; Schwarz, W, 2005) |
| "In contrast, analgesia, sedation and catalepsy were not observed in this dose range, but were apparent at 100 mg/kg." | 1.33 | Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy. ( Boulet, JM; Chaffer, SM; Elsemore, DA; Gottshall, SL; Harrison, JE; Koetzner, L; Lee, G; Mark, L; Miller, W; Pearson, MS; Rabadi, L; Rotshteyn, Y; Shan, S; Tafesse, L; Toth, M; Turchin, PI; Valenzano, KJ; Whiteside, GT, 2005) |
| "Both extracts can prevent convulsions as well as convulsion-related GABAergic neuron damage in the brain in the prolonged PTZ kindling model." | 1.33 | Study of antiepileptic effect of extracts from Acorus tatarinowii Schott. ( Chen, L; Gao, MM; Liao, WP; Su, T; Sun, WW; Yang, SQ; Yi, YH, 2005) |
| "Progestins can have antiseizure effects; however, the mechanisms and sites of action of these effects are not well-understood." | 1.33 | Actions at GABA(A) receptors in the hippocampus may mediate some antiseizure effects of progestins. ( Frye, CA; Rhodes, ME, 2005) |
| "Similar bilateral hyperalgesia was observed when axotomy was performed using silk thread instead of chromic gut." | 1.33 | Effects of amitriptyline and gabapentin on bilateral hyperalgesia observed in an animal model of unilateral axotomy. ( Miki, S; Senba, E; Yasuda, T; Yoshinaga, N, 2005) |
| "Signs of allodynia also extended to the sciatic nerve territory." | 1.33 | Behavioral, pharmacological and molecular characterization of the saphenous nerve partial ligation: a new model of neuropathic pain. ( Beaulieu, P; Desbiens, K; Leblond, F; Pichette, V; Walczak, JS, 2005) |
| " Following recovery, the phencyclidine dose-response curve was repeated in the fixed-interval paradigm." | 1.33 | Effects of phencyclidine on schedule-controlled responding following neurotoxic lesions of the striatum. ( Carlson, KM; Wagner, GC, 2005) |
| "Ischemia was induced by a 1 h transient middle cerebral artery occlusion (MCAO) in spontaneously hypertensive rats." | 1.33 | Decreased expression of vesicular GABA transporter, but not vesicular glutamate, acetylcholine and monoamine transporters in rat brain following focal ischemia. ( Vemuganti, R, 2005) |
| "In summary, arvanil does alleviate hyperkinesia typical of HD, although it also affects locomotion in normal rats." | 1.33 | Arvanil, a hybrid endocannabinoid and vanilloid compound, behaves as an antihyperkinetic agent in a rat model of Huntington's disease. ( de Lago, E; Di Marzo, V; Fernández-Ruiz, J; Ramos, JA; Urbani, P, 2005) |
| "Mefloquine dose dependently induced tonic seizures in mice." | 1.33 | Gamma-aminobutyric acid and mefloquine-induced seizures in mice. ( Amabeoku, GJ; Farmer, CC, 2005) |
| "After intracerebral hemorrhage (ICH), many changes of gene transcription occur that may be important because they will contribute to understanding mechanisms of injury and recovery." | 1.33 | Brain genomics of intracerebral hemorrhage. ( Ardizzone, TL; Lu, A; Ran, R; Sharp, FR; Tang, Y; Wagner, KR, 2006) |
| "Complete optic nerve transection was performed unilaterally in nine rats with survival for 1 (n = 4) and 3 (n = 5) months." | 1.33 | The effect of experimental glaucoma and optic nerve transection on amacrine cells in the rat retina. ( Kielczewski, JL; Pease, ME; Quigley, HA, 2005) |
| "The pathology of schizophrenia is characterized by increased hippocampal activity at baseline and during auditory hallucinations." | 1.33 | Regulation of synaptic plasticity in a schizophrenia model. ( Benes, FM; Bolshakov, VY; Gisabella, B, 2005) |
| "Neuropathic pain is characterised by hyperexcitability within nociceptive pathways that manifests behaviourally as allodynia and hyperalgesia and remains difficult to treat with standard analgesics." | 1.33 | Anti-nociception is selectively enhanced by parallel inhibition of multiple subtypes of monoamine transporters in rat models of persistent and neuropathic pain. ( Blackburn-Munro, G; Nielsen, AN; Pedersen, LH, 2005) |
| "The heightened susceptibility to seizures appears to be due, at least in part, to developmental changes that skew the balance between excitatory and inhibitory neurotransmitter systems in the brain in favor of a state of excitation." | 1.33 | Rearranging receptors. ( Brooks-Kayal, AR, 2005) |
| "Ten minutes of cerebral ischemia was produced by tightening the carotid ligatures bilaterally following hypotension." | 1.33 | Ischemic preconditioning ameliorates excitotoxicity by shifting glutamate/gamma-aminobutyric acid release and biosynthesis. ( Busto, R; Dave, KR; Lange-Asschenfeldt, C; Pérez-Pinzón, MA; Prado, R; Raval, AP; Saul, I, 2005) |
| "In vivo, it potently prevents seizures, pain-related behaviors and has anxiolytic-like activity in rodent models." | 1.33 | Activity profile of pregabalin in rodent models of epilepsy and ataxia. ( Bertram, E; Kinsora, JJ; Radulovic, LL; Serpa, KA; Taylor, CP; Vartanian, MG; Vergnes, M, 2006) |
| "Taurine pretreatment also caused about 2-fold increase in GABA concentration compared to 3-NP-treated animals." | 1.33 | Neuroprotective effect of taurine in 3-nitropropionic acid-induced experimental animal model of Huntington's disease phenotype. ( Abdel-Naim, AB; Arafa, HM; Khalifa, AE; Tadros, MG, 2005) |
| "Taurine is a semi-essential beta-amino acid that was demonstrated to have both antioxidant and GABA-A agonistic activity." | 1.33 | Neuroprotective effect of taurine in 3-nitropropionic acid-induced experimental animal model of Huntington's disease phenotype. ( Abdel-Naim, AB; Arafa, HM; Khalifa, AE; Tadros, MG, 2005) |
| "An experimental animal model of Huntington's disease (HD) phenotype was induced using the mycotoxin 3-nitropropionic acid (3-NP) and was well characterized behaviorally, neurochemically, morphometrically and histologically." | 1.33 | Neuroprotective effect of taurine in 3-nitropropionic acid-induced experimental animal model of Huntington's disease phenotype. ( Abdel-Naim, AB; Arafa, HM; Khalifa, AE; Tadros, MG, 2005) |
| " Dose-response studies with 6-hydroxydopamine revealed that the application of 200 microg per animal caused hypokinetic signs (decreased ambulatory activity, increased inactivity, and reduced motor coordination), which paralleled several signs of degeneration of nigrostriatal dopaminergic neurons (dopamine depletion in the caudate-putamen, and decreased mRNA levels for tyrosine hydroxylase and superoxide dismutase-1 and -2 in the substantia nigra)." | 1.33 | Effects of rimonabant, a selective cannabinoid CB1 receptor antagonist, in a rat model of Parkinson's disease. ( de Miguel, R; Fernández-Ruiz, J; García-Arencibia, M; González, S; Ramos, JA; Scorticati, C, 2006) |
| "Mechanical allodynia was maximal by 1 week and persisted at blunted levels for at least 18 weeks after injury." | 1.33 | Spinal nerve ligation does not alter the expression or function of GABA(B) receptors in spinal cord and dorsal root ganglia of the rat. ( Bettler, B; Engle, MP; Gassman, M; Hammond, DL; Sykes, KT, 2006) |
| "Temporal lobe epilepsy is the most common type of epilepsy in adults, and its pathophysiology remains unclear." | 1.33 | Hyperexcitability, interneurons, and loss of GABAergic synapses in entorhinal cortex in a model of temporal lobe epilepsy. ( Buckmaster, PS; Kumar, SS, 2006) |
| "Gamma-aminobutyric acid (GABA) levels were measured to determine selectivity." | 1.33 | Dopamine changes in a rat model of intracerebral hemorrhage. ( Cannon, JR; Hua, Y; Keep, RF; Nakamura, T; Richardson, RJ; Xi, G, 2006) |
| "In the rat model of intracerebral hemorrhage (ICH), behavioral deficits are first evident on day 1, with return to near control levels by day 28." | 1.33 | Dopamine changes in a rat model of intracerebral hemorrhage. ( Cannon, JR; Hua, Y; Keep, RF; Nakamura, T; Richardson, RJ; Xi, G, 2006) |
| "In particular, Alzheimer's disease (AD) is characterized by a selective loss of cholinergic neurons in the basal forebrain and nAChRs in particular regions controlling memory processes such as the cortex and the hippocampus." | 1.33 | Nicotine-induced enhancement of synaptic plasticity at CA3-CA1 synapses requires GABAergic interneurons in adult anti-NGF mice. ( Cattaneo, A; Cherubini, E; Rosato-Siri, M, 2006) |
| "Limbic seizures were evoked in freely moving rats by intrahippocampal administration of pilocarpine via a microdialysis probe." | 1.33 | Substantia nigra is an anticonvulsant site of action of topiramate in the focal pilocarpine model of limbic seizures. ( Clinckers, R; Ebinger, G; Meurs, A; Michotte, Y; Smolders, I, 2006) |
| "Reboxetine is a selective norepinephrine (NE) reuptake inhibitor that exerts significant antidepressant action." | 1.32 | Norepinephrine-gamma-aminobutyric acid (GABA) interaction in limbic stress circuits: effects of reboxetine on GABAergic neurons. ( Bodie, B; Herman, JP; Renda, A, 2003) |
| "Two weeks after induction of hydrocephalus the taurine concentration was decreased, whereas the concentration of [1,2-13C]lactate was increased in the cerebrum and that of [1,2-13C]GABA in the brainstem." | 1.32 | Astrocyte metabolism is disturbed in the early development of experimental hydrocephalus. ( Brinker, T; Kondziella, D; Lüdemann, W; Qu, H; Sletvold, O; Sonnewald, U, 2003) |
| "We introduced intracerebral hemorrhage in each of eight anesthetized New Zealand rabbits by injecting 0." | 1.32 | Extracellular glutamate and other amino acids in experimental intracerebral hemorrhage: an in vivo microdialysis study. ( Ali, Z; Baker, G; Guterman, LR; Hopkins, LN; Qureshi, AI; Shuaib, A; Suri, MF; Todd, K, 2003) |
| "The degree of allodynia was most marked following 10 min of irradiation." | 1.32 | Gabapentin reverses mechanical allodynia induced by sciatic nerve ischemia and formalin-induced nociception in mice. ( Berge, OG; Brodin, E; Flood, K; Gustafsson, H; Olgart, L; Stiller, CO, 2003) |
| "So far ASPA deficiency and elevated NAA have been ascribed with the CD." | 1.32 | Expression of glutamate transporter, GABRA6, serine proteinase inhibitor 2 and low levels of glutamate and GABA in the brain of knock-out mouse for Canavan disease. ( Campbell, GA; Ezell, EL; Matalon, R; Michals-Matalon, K; Quast, MJ; Rady, PL; Rassin, DK; Surendran, S; Szucs, S; Tyring, SK; Wei, J, 2003) |
| "It has been hypothesized that alcohol addiction is mediated, at least in part, by specific gamma-aminobutyric acid(A) (GABA(A)) receptors within the ventral pallidum (VP)." | 1.32 | The reinforcing properties of alcohol are mediated by GABA(A1) receptors in the ventral pallidum. ( Carroll, MR; Cook, JM; Cummings, R; Eiler, WJ; Foster, KL; Garcia, M; Grey, C; Harvey, SC; Jones, CM; June, HL; Ma, C; Mason, D; McCane, S; McKay, PF; Sarma, PV; Seyoum, R; Skolnick, P; Woods, JE; Yin, W, 2003) |
| "Temporal lobe epilepsy is the most common type of epilepsy in adults, and its underlying mechanisms are unclear." | 1.32 | Reduced inhibition and increased output of layer II neurons in the medial entorhinal cortex in a model of temporal lobe epilepsy. ( Buckmaster, PS; Kobayashi, M; Wen, X, 2003) |
| "3." | 1.32 | Pharmacological characterisation of a rat model of incisional pain. ( Boulet, J; Gottshall, S; Harrison, J; Mark, L; Pearson, M; Walker, K; Whiteside, GT, 2004) |
| "Both clinical and preclinical models of postsurgical pain are being used more frequently in the early evaluation of new chemical entities." | 1.32 | Pharmacological characterisation of a rat model of incisional pain. ( Boulet, J; Gottshall, S; Harrison, J; Mark, L; Pearson, M; Walker, K; Whiteside, GT, 2004) |
| "The present study compares postoperative pain scores in male and female rats and how they respond to analgesic interventions." | 1.32 | Postoperative pain and analgesic responses are similar in male and female Sprague-Dawley rats. ( Buvanendran, A; Kroin, JS; Nagalla, SK; Tuman, KJ, 2003) |
| "In the plantar foot incision model of postoperative pain there was no gender difference in postoperative mechanical hypersensitivity (von Frey filaments) over four days." | 1.32 | Postoperative pain and analgesic responses are similar in male and female Sprague-Dawley rats. ( Buvanendran, A; Kroin, JS; Nagalla, SK; Tuman, KJ, 2003) |
| "ent/ent mice develop ataxia by postnatal day 13-15, followed by paroxysmal dyskinesia a few days later." | 1.32 | entla, a novel epileptic and ataxic Cacna2d2 mutant of the mouse. ( Becker, CM; Becker, K; Boison, D; Brill, J; Gouder, N; Hofmann, F; Klocke, R; Klugbauer, N; Paul, D, 2004) |
| "Furthermore, amyloid plaque size was shown to have a statistically significant effect on the relative area occupied by dystrophic glutamatergic neurites in the peri-plaque neuropile." | 1.32 | Structural involvement of the glutamatergic presynaptic boutons in a transgenic mouse model expressing early onset amyloid pathology. ( Bell, KF; Cuello, AC; de Kort, GJ; Ribeiro-da-Silva, A; Shigemoto, R; Steggerda, S, 2003) |
| "While the cholinergic depletion in Alzheimer's disease (AD) has been known for some time, a definitive involvement of other neurotransmitter systems has been somewhat more elusive." | 1.32 | Structural involvement of the glutamatergic presynaptic boutons in a transgenic mouse model expressing early onset amyloid pathology. ( Bell, KF; Cuello, AC; de Kort, GJ; Ribeiro-da-Silva, A; Shigemoto, R; Steggerda, S, 2003) |
| "SCA3 or Machado-Joseph disease (MJD) is the commonest dominant inherited ataxia disease, with pathological phenotypes apparent with a CAG triplet repeat length of 61-84." | 1.32 | Defining a metabolic phenotype in the brain of a transgenic mouse model of spinocerebellar ataxia 3. ( Cemal, CK; Griffin, JL; Pook, MA, 2004) |
| " This dosage produced a substantial but non-significant decrease in the incidence of postherpetic pain-related responses." | 1.32 | Effects of the suppression of acute herpetic pain by gabapentin and amitriptyline on the incidence of delayed postherpetic pain in mice. ( Kuraishi, Y; Nojima, H; Shiraki, K; Takahata, H; Takasaki, I, 2004) |
| "Nonconvulsive seizures (NCSs) after traumatic and ischemic brain injury are often refractory to antiepileptic drug therapy and are associated with a decline in patient outcome." | 1.32 | Antiepileptic drug treatment of nonconvulsive seizures induced by experimental focal brain ischemia. ( Hartings, JA; Lu, XM; Moreton, JE; Tortella, FC; Williams, AJ, 2004) |
| "In prior work, we reported that, during cataplexy, noradrenergic neurons cease discharge, and serotonergic neurons greatly reduce activity." | 1.32 | Cataplexy-active neurons in the hypothalamus: implications for the role of histamine in sleep and waking behavior. ( Boehmer, LN; John, J; Siegel, JM; Wu, MF, 2004) |
| "The present study investigated whether mechanical allodynia following contusive spinal cord injury (SCI) of the thoracic segments 12 and 13 of the rat was associated with a reduction in gamma-aminobutyric acid (GABA)ergic inhibition adjacent to the site of injury." | 1.32 | Mechanical allodynia following contusion injury of the rat spinal cord is associated with loss of GABAergic inhibition in the dorsal horn. ( Drew, GM; Duggan, AW; Siddall, PJ, 2004) |
| "Vigabatrin was anticonvulsant in all groups for up to 13 days with a maximal effect 24 h after injection." | 1.32 | The central piriform cortex: anatomical connections and anticonvulsant effect of GABA elevation in the kindling model. ( Ebert, U; Löscher, W; Schwabe, K, 2004) |
| "Infantile neuronal ceroid lipofuscinosis (INCL) is one of a group of fatal hereditary lysosomal storage disorders." | 1.32 | Regional and cellular neuropathology in the palmitoyl protein thioesterase-1 null mutant mouse model of infantile neuronal ceroid lipofuscinosis. ( Bible, E; Cooper, JD; Gupta, P; Hofmann, SL, 2004) |
| "It remains unclear whether the seizures result from aberrant neuronal placement, disruption of intrinsic properties of neurons, or both." | 1.32 | Epileptic-like convulsions associated with LIS-1 in the cytoskeletal control of neurotransmitter signaling in Caenorhabditis elegans. ( Braden, AL; Caldwell, GA; Caldwell, KA; Locke, CJ; Williams, SN, 2004) |
| "Identical convulsions were obtained using C." | 1.32 | Epileptic-like convulsions associated with LIS-1 in the cytoskeletal control of neurotransmitter signaling in Caenorhabditis elegans. ( Braden, AL; Caldwell, GA; Caldwell, KA; Locke, CJ; Williams, SN, 2004) |
| "Electroconvulsions were produced by means of an alternating current (ear-clip electrodes, 0." | 1.31 | Effect of gabapentin on the anticonvulsant activity of antiepileptic drugs against electroconvulsions in mice: an isobolographic analysis. ( Borowicz, KK; Czuczwar, SJ; Luszczki, J; Swiader, M, 2002) |
| "The initial hyperalgesia induced by 0." | 1.31 | Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia. ( Assié, MB; Bardin, L; Carilla-Durand, E; Colpaert, FC; Cosi, C; Koek, W; Pauwels, PJ; Tarayre, JP; Vacher, B; Wiesenfeld-Hallin, Z; Xu, XJ, 2002) |
| "Quisqualic acid was injected into the right nucleus basalis of rats." | 1.31 | Brain inflammatory reaction in an animal model of neuronal degeneration and its modulation by an anti-inflammatory drug: implication in Alzheimer's disease. ( Casamenti, F; Pepeu, G; Prosperi, C; Scali, C; Vannucchi, MG, 2000) |
| "Allodynia and hyperalgesia appeared on day 5 post-inoculation." | 1.31 | Pharmacological and immunohistochemical characterization of a mouse model of acute herpetic pain. ( Andoh, T; Kuraishi, Y; Nemoto, H; Nitta, M; Nojima, H; Shiraki, K; Takahata, H; Takasaki, I, 2000) |
| "Immunization with the whole-cell pertussis vaccine (Pw), while effective at preventing whooping cough in infants, has been associated with local, systemic, and neuronal reactions, including fevers and convulsions in children." | 1.31 | Whole-cell but not acellular pertussis vaccines induce convulsive activity in mice: evidence of a role for toxin-induced interleukin-1beta in a new murine model for analysis of neuronal side effects of vaccination. ( Donnelly, S; Loscher, CE; Lynch, MA; Mills, KH, 2001) |
| "Kindled seizures were produced on day 16 of life by repeatedly applying an electrical current stimulus to the amygdala electrode." | 1.31 | Anticonvulsant efficacy of gabapentin on kindling in the immature brain. ( Lado, FA; Moshé, SL; Sperber, EF, 2001) |
| "Subjective tinnitus is a common and often debilitating disorder that is difficult to study because it is a perceptual state without an objective stimulus correlate." | 1.31 | Assessing tinnitus and prospective tinnitus therapeutics using a psychophysical animal model. ( Bauer, CA; Brozoski, TJ, 2001) |
| "Chronic tinnitus was induced in rats by a single intense unilateral exposure to noise." | 1.31 | Assessing tinnitus and prospective tinnitus therapeutics using a psychophysical animal model. ( Bauer, CA; Brozoski, TJ, 2001) |
| "Efflux of glutamate during cerebral ischemia is known to contribute to brain cell death via processes of excitotoxicity." | 1.31 | Profiles of glutamate and GABA efflux in core versus peripheral zones of focal cerebral ischemia in mice. ( Lo, EH; Moskowitz, MA; Newcomb, R; Shimizu-Sasamata, M; Wang, X, 2001) |
| "Lamotrigine was the only drug which antagonized tonic convulsions in the MES test (ED50 = 36 mumol/kg)." | 1.30 | Comparison of the preclinical anticonvulsant profiles of tiagabine, lamotrigine, gabapentin and vigabatrin. ( Dalby, NO; Nielsen, EB, 1997) |
| "Tiagabine is a novel antiepileptic drug which has clinical efficacy against complex refractory and myoclonic seizures." | 1.30 | Comparison of the preclinical anticonvulsant profiles of tiagabine, lamotrigine, gabapentin and vigabatrin. ( Dalby, NO; Nielsen, EB, 1997) |
| "Tiagabine was the most potent drug in antagonizing tonic convulsions induced by PTZ, DMCM and sound induced seizures in DBA/2 mice with ED50 values of 2, 2 and 1 mumol/kg, respectively, followed by lamotrigine with ED50 values of 9, 43 and 6 mumol/kg, respectively." | 1.30 | Comparison of the preclinical anticonvulsant profiles of tiagabine, lamotrigine, gabapentin and vigabatrin. ( Dalby, NO; Nielsen, EB, 1997) |
| "The pathophysiology of idiopathic dystonia, characterized by sustained twisting movements and postures, is still unknown." | 1.30 | Alterations in spontaneous single unit activity of striatal subdivisions during ontogenesis in mutant dystonic hamsters. ( Gernert, M; Löscher, W; Richter, A, 1999) |
| "Using this animal model of Huntington's disease, we investigated the ability of the insulin-like growth factor-I (IGF-I) amino-terminal tripeptide glycine-proline-glutamate (GPE) to protect striatal neurons from degeneration." | 1.30 | The IGF-I amino-terminal tripeptide glycine-proline-glutamate (GPE) is neuroprotective to striatum in the quinolinic acid lesion animal model of Huntington's disease. ( Alexi, T; Clark, RG; Faull, RL; Gluckman, PD; Hughes, PE; van Roon-Mom, WM; Williams, CE, 1999) |
| "Huntington's disease is an incurable genetic neurological disorder characterized by the relatively selective degeneration of the striatum." | 1.30 | The IGF-I amino-terminal tripeptide glycine-proline-glutamate (GPE) is neuroprotective to striatum in the quinolinic acid lesion animal model of Huntington's disease. ( Alexi, T; Clark, RG; Faull, RL; Gluckman, PD; Hughes, PE; van Roon-Mom, WM; Williams, CE, 1999) |
| "This is a model of partial epilepsy consisting of an enduring paraoxysmal activity recorded at the site of GABA infusion that depends, for its induction, on GABA receptor activation." | 1.29 | Allopregnanolone potentiates a GABA-withdrawal syndrome in the rat cerebral cortex. ( Brailowsky, S; Calixto, E; Lemini, C; Montiel, T, 1995) |
| "tended to decrease seizure intensity and at a dose of 10 mg/kg was ineffective at all." | 1.29 | Further evidence for the interactions between angiotensin II and GABAergic transmission in pentylenetetrazol kindling seizures in mice. ( Georgiev, VP; Kambourova, TS; Lazarova, MB, 1995) |
| "Chronic administration of haloperidol to male Sprague Dawley rats for 6 months at a dosage of 1." | 1.29 | Tiagabine inhibits haloperidol-induced oral dyskinesias in rats. ( Friedman, MB; Gao, XM; Kakigi, T; Tamminga, CA, 1994) |
| "Since gyrate atrophy, an autosomal recessive human disease, is characterized by the absence of OAT, special emphasis was put on the study of the visual system." | 1.29 | Some biochemical and pathophysiological aspects of long-term elevation of brain ornithine concentrations. ( Bonaventure, N; Daune-Anglard, G; Seiler, N, 1993) |
| "Kainic acid (KA)-induced convulsions are accompanied by histopathological changes that are most prominent in the temporal lobe structures." | 1.29 | Alpha 2-adrenoceptor agonist, dexmedetomidine, protects against kainic acid-induced convulsions and neuronal damage. ( Halonen, T; Kotti, T; Miettinen, R; Riekkinen, PJ; Toppinen, A; Tuunanen, J, 1995) |
| "Gabapentin dose-dependently attenuated myoclonus in posthypoxic rats for more than 3 h." | 1.29 | Antimyoclonic effect of gabapentin in a posthypoxic animal model of myoclonus. ( Kanthasamy, AG; Truong, DD; Vu, TQ; Yun, RJ, 1996) |
| "The effect of intrauterine growth retardation (IUGR) on striatal energy metabolites and amino acid concentrations was studied in the fetuses of eight nulliparous rat dams after uterine artery ligation on day 18 of gestation." | 1.28 | Cerebral amino acids and energy metabolites in the growth retarded rat fetus under normoxia and hypoxia. ( Andiné, P; Hagberg, H; Lehmann, A; Thordstein, M, 1992) |
| "Vigabatrin proved to be a potent anticonvulsant drug at acute doses (100-200 mg/kg), but during chronic administration, the anticonvulsant activity of the treatment was lost already in the second week of treatment." | 1.28 | Development of tolerance to the anticonvulsant effect of vigabatrin in amygdala-kindled rats. ( Löscher, W; Rundfeldt, C, 1992) |
| "All amphetamine treatments diminished the potassium-stimulated (50 mM) release of preloaded labelled dopamine from superfused striatal and frontal cortical slices in vitro." | 1.28 | Animal models of amphetamine psychosis: neurotransmitter release from rat brain slices. ( Lillrank, SM; Oja, SS; Saransaari, P; Seppälä, T, 1991) |
| "Paradoxically, GABA agonists increased seizure occurrence while GABA antagonists decreased seizure occurrence." | 1.28 | Paradoxical role of GABA in a chronic model of petit mal (absence)-like epilepsy in the rat. ( Bierkamper, GG; Smith, KA, 1990) |
| " This phenomenon, probably due to the inhibition of the striato-nigral GABA-ergic pathway, could serve as an easy and reliable model for the human tardive dyskinesias dues to the chronic administration of neuroleptics." | 1.28 | [Oral dyskinesia in rats after a single administration of haloperidol combined with GABA-linoleamide. A model of dyskinesia in man]. ( Vamvakides, A, 1989) |
| "Galactosamine-induced hepatic coma is not associated with any functionally significant changes in the molecular components of the postsynaptic dopamine receptor." | 1.27 | [Pathogenesis of hepatic encephalopathy--studies in the rabbit model of acute liver failure]. ( Ferenci, P; Jones, EA; Pappas, SC; Schafer, DF, 1984) |
| "Valproic acid was included as a reference standard." | 1.27 | High anticonvulsant potency of gamma-aminobutyric acid (GABA)mimetic drugs in gerbils with genetically determined epilepsy. ( Frey, HH; Löscher, W; Reiche, R; Schultz, D, 1983) |
| "In ongoing studies of chronic administration of neuroleptics to monkeys (Cebus apella) and rats, the regional distribution of glutamic acid decarboxylase (GAD) and brain levels of homovanillic acid were examined." | 1.27 | Experimental tardive dyskinesia. ( Gunne, LM; Häggström, JE, 1985) |
| "Fengabine (SL 79." | 1.27 | Fengabine, a novel antidepressant GABAergic agent. I. Activity in models for antidepressant drugs and psychopharmacological profile. ( Bartholini, G; Depoortere, H; Lloyd, KG; Sanger, D; Zivkovic, B, 1987) |
| " Cetyl GABA failed to show a linear dose-response against minor seizures but was quite potent against major ones (ED 50 4." | 1.27 | Anticonvulsant action of GABA agonists and prodrugs on minor and major seizures in epileptic gerbils. Comparison with mouse models of seizure states. ( Löscher, W, 1985) |
| "pentylenetetrazol-induced seizures in mice." | 1.27 | Anticonvulsant action of GABA agonists and prodrugs on minor and major seizures in epileptic gerbils. Comparison with mouse models of seizure states. ( Löscher, W, 1985) |
| "In a rabbit model the development of hepatic encephalopathy was associated with increased levels of GABA in plasma, increased permeability of the blood-brain barrier, increased numbers of binding-sites for GABA and benzodiazepines in the brain, and a pattern of neural activity similar to that induced by drugs which activate the GABA neurotransmitter system." | 1.26 | Hepatic encephalopathy and the gamma-aminobutyric-acid neurotransmitter system. ( Jones, EA; Schafer, DF, 1982) |
| "Thus, hepatic encephalopathy appears to involve partial degeneration of the gamma-aminobutyric acid-containing presynaptic nerve terminals." | 1.26 | Experimental hepatic encephalopathy: changes in the binding of gamma-aminobutyric acid. ( Baraldi, M; Zeneroli, ZL, 1982) |
| "Penicillin seizures do not cause a change in levels of GABA, but result in a decrease in glutamate within the focus." | 1.26 | Effect of amino-oxyacetic acid (AOAA) on focal penicillin seizures. ( Collins, RC; Mehta, S, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 94 (5.91) | 18.7374 |
| 1990's | 111 (6.98) | 18.2507 |
| 2000's | 514 (32.31) | 29.6817 |
| 2010's | 745 (46.83) | 24.3611 |
| 2020's | 127 (7.98) | 2.80 |
| Authors | Studies |
|---|---|
| Chang, S | 1 |
| Bray, SM | 1 |
| Li, Z | 6 |
| Zarnescu, DC | 1 |
| He, C | 1 |
| Jin, P | 1 |
| Warren, ST | 1 |
| Liu, H | 4 |
| Altenbach, RJ | 1 |
| Carr, TL | 1 |
| Chandran, P | 2 |
| Hsieh, GC | 2 |
| Lewis, LG | 2 |
| Manelli, AM | 1 |
| Milicic, I | 1 |
| Marsh, KC | 1 |
| Miller, TR | 1 |
| Strakhova, MI | 1 |
| Vortherms, TA | 1 |
| Wakefield, BD | 1 |
| Wetter, JM | 1 |
| Witte, DG | 1 |
| Honore, P | 1 |
| Esbenshade, TA | 1 |
| Brioni, JD | 1 |
| Cowart, MD | 1 |
| Koh, M | 1 |
| Lee, JC | 1 |
| Min, C | 1 |
| Moon, A | 1 |
| Gunia-Krzyżak, A | 1 |
| Żelaszczyk, D | 1 |
| Rapacz, A | 1 |
| Żesławska, E | 1 |
| Waszkielewicz, AM | 1 |
| Pańczyk, K | 1 |
| Słoczyńska, K | 1 |
| Pękala, E | 1 |
| Nitek, W | 1 |
| Filipek, B | 1 |
| Marona, H | 1 |
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 6 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Kumar, M | 1 |
| Singh, G | 1 |
| Kushwah, AS | 1 |
| Surampalli, G | 1 |
| Singh, TG | 1 |
| Gupta, S | 1 |
| Takado, Y | 1 |
| Takuwa, H | 1 |
| Sampei, K | 1 |
| Urushihata, T | 1 |
| Takahashi, M | 3 |
| Shimojo, M | 1 |
| Uchida, S | 1 |
| Nitta, N | 1 |
| Shibata, S | 1 |
| Nagashima, K | 1 |
| Ochi, Y | 1 |
| Ono, M | 1 |
| Maeda, J | 1 |
| Tomita, Y | 1 |
| Sahara, N | 1 |
| Near, J | 1 |
| Aoki, I | 1 |
| Shibata, K | 1 |
| Higuchi, M | 1 |
| Pankowska, A | 1 |
| Chudzik, A | 1 |
| Słowik, T | 1 |
| Łazorczyk, A | 1 |
| Kochalska, K | 1 |
| Andres-Mach, M | 1 |
| Lam, WW | 1 |
| Pietura, R | 1 |
| Rola, R | 1 |
| Stanisz, GJ | 1 |
| Orzyłowska, A | 1 |
| Ahn, Y | 2 |
| Hong, KB | 1 |
| Kim, S | 3 |
| Suh, HJ | 2 |
| Jo, K | 2 |
| Zhang, X | 5 |
| Liu, Y | 6 |
| Hong, X | 1 |
| Li, X | 13 |
| Meshul, CK | 1 |
| Moore, C | 1 |
| Yang, Y | 6 |
| Han, Y | 1 |
| Li, WG | 3 |
| Qi, X | 2 |
| Lou, H | 1 |
| Duan, S | 4 |
| Xu, TL | 3 |
| Tong, X | 1 |
| Dou, Y | 1 |
| Xie, J | 2 |
| Tan, Y | 1 |
| Zhang, M | 5 |
| Zhao, Y | 5 |
| Liu, X | 4 |
| Kiemes, A | 1 |
| Gomes, FV | 1 |
| Cash, D | 2 |
| Uliana, DL | 1 |
| Simmons, C | 2 |
| Singh, N | 3 |
| Vernon, AC | 1 |
| Turkheimer, F | 1 |
| Davies, C | 1 |
| Stone, JM | 1 |
| Grace, AA | 1 |
| Modinos, G | 1 |
| Min, B | 1 |
| Cho, HJ | 1 |
| Kwak, WK | 1 |
| Ngoupaye, GT | 2 |
| Mokgokong, M | 1 |
| Madlala, T | 1 |
| Mabandla, MV | 2 |
| Waloschková, E | 1 |
| Gonzalez-Ramos, A | 1 |
| Mikroulis, A | 1 |
| Kudláček, J | 1 |
| Andersson, M | 1 |
| Ledri, M | 1 |
| Kokaia, M | 1 |
| Qi, G | 1 |
| Zhang, P | 2 |
| Li, T | 1 |
| Li, M | 3 |
| Zhang, Q | 2 |
| He, F | 1 |
| Zhang, L | 5 |
| Cai, H | 1 |
| Lv, X | 1 |
| Qiao, H | 1 |
| Chen, X | 3 |
| Ming, J | 1 |
| Tian, B | 1 |
| Rathwa, N | 1 |
| Parmar, N | 1 |
| Palit, SP | 1 |
| Patel, R | 1 |
| Bhaskaran, RS | 1 |
| Ramachandran, AV | 1 |
| Begum, R | 2 |
| Santrač, A | 2 |
| Bijelić, D | 1 |
| Stevanović, V | 2 |
| Banićević, M | 1 |
| Aranđelović, J | 2 |
| Batinić, B | 2 |
| Sharmin, D | 2 |
| Cook, JM | 3 |
| Savić, MM | 2 |
| Tanenhaus, A | 1 |
| Stowe, T | 1 |
| Young, A | 1 |
| McLaughlin, J | 1 |
| Aeran, R | 1 |
| Lin, IW | 1 |
| Li, J | 11 |
| Hosur, R | 1 |
| Chen, M | 3 |
| Leedy, J | 1 |
| Chou, T | 1 |
| Pillay, S | 1 |
| Vila, MC | 1 |
| Kearney, JA | 1 |
| Moorhead, M | 1 |
| Belle, A | 1 |
| Tagliatela, S | 2 |
| Ma, SY | 1 |
| Kwan, KM | 1 |
| Fahmy, AM | 1 |
| William, S | 1 |
| Hegab, A | 1 |
| Tm, D | 1 |
| Nakao, K | 1 |
| Singh, M | 1 |
| Sapkota, K | 1 |
| Fitzgerald, A | 1 |
| Hablitz, JJ | 2 |
| Nakazawa, K | 2 |
| Bove, M | 1 |
| Schiavone, S | 1 |
| Tucci, P | 1 |
| Sikora, V | 1 |
| Dimonte, S | 1 |
| Colia, AL | 1 |
| Morgese, MG | 1 |
| Trabace, L | 1 |
| Zhu, N | 1 |
| Wei, M | 1 |
| Yuan, L | 1 |
| He, X | 2 |
| Chen, C | 1 |
| Ji, A | 1 |
| Zhang, G | 3 |
| Lee, MT | 2 |
| Mouri, A | 2 |
| Kubota, H | 1 |
| Lee, HJ | 7 |
| Chang, MH | 1 |
| Wu, CY | 2 |
| Knutson, DE | 2 |
| Mihovilovic, M | 1 |
| Cook, J | 3 |
| Sieghart, W | 3 |
| Nabeshima, T | 2 |
| Chiou, LC | 3 |
| Chu, MC | 1 |
| Wu, HF | 1 |
| Lee, CW | 1 |
| Chung, YJ | 1 |
| Chi, H | 1 |
| Chen, PS | 1 |
| Lin, HC | 2 |
| Todorović, L | 1 |
| Tiruveedhula, VVNPB | 1 |
| Rashid, F | 1 |
| Stanojević, B | 1 |
| Kovács, Z | 1 |
| Skatchkov, SN | 1 |
| Szabó, Z | 1 |
| Qahtan, S | 1 |
| Méndez-González, MP | 1 |
| Malpica-Nieves, CJ | 1 |
| Eaton, MJ | 2 |
| Kardos, J | 2 |
| Héja, L | 2 |
| Ferrari, LL | 1 |
| Ogbeide-Latario, OE | 1 |
| Gompf, HS | 1 |
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| Zhu, Y | 3 |
| Zhang, Y | 10 |
| Lian, Y | 1 |
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| Jia, J | 3 |
| Yang, C | 1 |
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| Li, Y | 10 |
| Mi, J | 1 |
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| Yang, L | 7 |
| Singla, R | 2 |
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| Krook-Magnuson, E | 1 |
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| Mohamad, MI | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A 57-Week, Multicenter, Active-treatment, Open-label Extension Trial of CVL-865 as Adjunctive Therapy in Adults With Drug-Resistant Focal Onset Seizures[NCT04686786] | Phase 2 | 120 participants (Anticipated) | Interventional | 2020-12-08 | Enrolling by invitation | ||
| A Randomized, Double-blind, Placebo-controlled, Parallel Group, Multicenter Trial of CVL-865 as Adjunctive Therapy in Adults With Drug-Resistant Focal Onset Seizures (REALIZE Trial)[NCT04244175] | Phase 2 | 150 participants (Anticipated) | Interventional | 2020-01-27 | Recruiting | ||
| Quantitative MRI and GABA Spectroscopy to Localize the Epileptic Zone[NCT06057233] | 40 participants (Anticipated) | Observational | 2024-03-31 | Not yet recruiting | |||
| Gabapentin Regimens and Their Effects on Opioid Consumption[NCT03334903] | Phase 4 | 77 participants (Actual) | Interventional | 2018-05-15 | Completed | ||
| The Protective Role of Preoperative Stimulation of the Distal Limb of the Ileostomy Loop With GABA Before Ileostomy Closure[NCT05905393] | Phase 3 | 80 participants (Anticipated) | Interventional | 2023-06-30 | Not yet recruiting | ||
| Biperiden for Prevention of Epilepsy in Patients With Traumatic Brain Injury[NCT04945213] | Phase 3 | 312 participants (Anticipated) | Interventional | 2023-01-10 | Recruiting | ||
| Ketogenic Diet Interventions in Parkinson's Disease: Safeguarding the Gut Microbiome[NCT05469997] | 50 participants (Anticipated) | Interventional | 2023-01-31 | Not yet recruiting | |||
| Ketogenic Diet Effects on the Frequency of Non Epileptic Seizures in Patients With Dissociative Neurological Symptom Disorder: a Pilot Study[NCT05219006] | 17 participants (Actual) | Interventional | 2021-07-15 | Completed | |||
| The Role of Gut Microbiota in Children With Epilepsy Following Ketogenic Diet[NCT05898438] | 20 participants (Anticipated) | Observational | 2019-12-18 | Recruiting | |||
| Prednisolone vs. Vigabatrin in the First-line Treatment of Infantile Spasms[NCT02299115] | Phase 3 | 0 participants (Actual) | Interventional | 2017-09-05 | Withdrawn (stopped due to Most centres are now using oral steroids as 1st line treatment so question of efficacy is no longer of high interest.) | ||
| Neuroactive Steroids in Acute Ischemic Stroke: Association With Cognitive, Functional and Neurological Outcomes.[NCT02914106] | 60 participants (Actual) | Observational | 2014-06-30 | Completed | |||
| Changes in Plasma Cortisol, Brain-derived Neurotrophic Factor, and Nitrites in Patients With Acute Ischemic Stroke[NCT03242304] | 40 participants (Actual) | Observational | 2016-04-01 | Completed | |||
| A Randomised Double Blind Placebo Controlled 12 Week Trial of Methotrexate Added to Treatment As Usual in Early Schizophrenia[NCT02074319] | Phase 1 | 92 participants (Actual) | Interventional | 2013-12-31 | Completed | ||
| A Randomized Controlled Trial of Adjunctive Siltuximab in Schizophrenia[NCT02796859] | Phase 1/Phase 2 | 30 participants (Anticipated) | Interventional | 2016-05-31 | Recruiting | ||
| An Open-Label Trial of Tocilizumab in Schizophrenia[NCT01696929] | Phase 1 | 8 participants (Actual) | Interventional | 2012-09-30 | Completed | ||
| Priming With High-Frequency Trans-spinal Stimulation to Augment Locomotor Benefits in Spinal Cord Injury[NCT04807764] | 45 participants (Anticipated) | Interventional | 2021-08-01 | Recruiting | |||
| The Efficacy of Strategic Memory Training Coupled With Non-invasive Brain Stimulation Techniques in Healthy Aging Population and Subjective Cognitive Decline Patients: a Randomized-controlled Study[NCT05929872] | 56 participants (Anticipated) | Interventional | 2023-07-30 | Not yet recruiting | |||
| A Randomised, Double-Blind, Placebo-Controlled 6-month Study to Evaluate the Efficacy, Safety, and Tolerability of Sarizotan in Patients With Rett Syndrome With Respiratory Symptoms[NCT02790034] | Phase 2/Phase 3 | 129 participants (Actual) | Interventional | 2016-10-26 | Terminated (stopped due to The study did not demonstrate evidence of efficacy on the primary or secondary efficacy variables) | ||
| Transcranial Direct Current Stimulation on Inhibitory Control in Addictions: a Triple-blinded, Sham-controlled Clinical Trial.[NCT05350033] | 200 participants (Anticipated) | Interventional | 2021-04-05 | Enrolling by invitation | |||
| Magnetic Resonance Imaging of the Brain in Children With Autism Spectrum Disorder (ASD)[NCT05758220] | 25 participants (Anticipated) | Observational [Patient Registry] | 2023-04-01 | Not yet recruiting | |||
| A Phase I Randomized, Double-blinded, Placebo-controlled Dose Escalation Study to Evaluate the Safety, Tolerability, and Pharmacokinetic of HS-10353 in Chinese Adult Subjects[NCT05195203] | Phase 1 | 96 participants (Actual) | Interventional | 2021-01-27 | Completed | ||
| Role of the Gut Microbiome as Determinant of Depression in Multiple Sclerosis Subjects[NCT05808101] | 120 participants (Anticipated) | Observational | 2022-01-27 | Recruiting | |||
| Effect of Vigiis 101 Lactic Acid Bacteria Powder on Body Weight and Body Fat in Overweight Participants: a Randomized, Double-blinded, Placebo-controlled Trial[NCT05869799] | 100 participants (Anticipated) | Interventional | 2023-05-01 | Recruiting | |||
| Functional Assessment in The Intestinal Flora Improvement[NCT04088474] | 36 participants (Actual) | Interventional | 2016-03-05 | Completed | |||
| Effects of Vigiis 101-LAB on Gut Health[NCT04046432] | 54 participants (Actual) | Interventional | 2017-03-27 | Completed | |||
| Modulation of the Activity in the Cerebellum With Transcranial Direct Current Stimulation in Autistic Participants[NCT05781412] | 100 participants (Anticipated) | Interventional | 2022-05-24 | Recruiting | |||
| Treatment Development of Triheptanoin for Glucose Transporter Type I Deficiency[NCT02021526] | Phase 1/Phase 2 | 0 participants (Actual) | Interventional | 2015-12-31 | Withdrawn (stopped due to NIH funding resulted in new clinical trial) | ||
| Clinical Trial of Etanercept (TNF-α Blocker) for Treatment of Blast-Induced Tinnitus[NCT04066348] | Phase 2 | 310 participants (Anticipated) | Interventional | 2022-07-01 | Recruiting | ||
| Phase I Study of Subthalamic GAD Gene Transfer in Medically Refractory Parkinson's Disease Patients[NCT00195143] | Phase 1 | 12 participants | Interventional | 2003-08-31 | Completed | ||
| Opioid-Induced Hyperalgesia in Prescription Opioid Abusers: Effects of Pregabalin[NCT01821430] | Phase 2 | 4 participants (Actual) | Interventional | 2013-03-31 | Terminated (stopped due to poor recruitment) | ||
| Efficacy of Pregabalin and Duloxetine in Patients With Painful Diabetic Peripheral Neuropathy (PDPN): the Effect of Pain on Cognitive Function, Sleep and Quality of Life (BLOSSOM)[NCT04246619] | Phase 4 | 254 participants (Actual) | Interventional | 2019-11-12 | Terminated (stopped due to The statistical analysis will still provide relevant results with the same statistical power as initially planned.COVID-19 pandemic prolonged the recruiting period and consequently affected the costs of the clinical trial.) | ||
| Use of Single Dose Pre-Operative Pregabalin for Post-Operative Analgesia in Bilateral Head and Neck Cancer Surgery: A Randomized, Double-Blinded, Placebo-Controlled Trial[NCT03714867] | Phase 4 | 0 participants (Actual) | Interventional | 2019-03-22 | Withdrawn (stopped due to Inability to recruit patients) | ||
| Pharmacokinetic Non-interaction Study Between Pregabalin 150 mg and Tramadol 50 mg, Administered Individually or in Combination, Single Dose in Healthy Subjects of Both Genders Under Fasting Conditions[NCT05389150] | Phase 1 | 30 participants (Actual) | Interventional | 2019-01-17 | Completed | ||
| The Effect of Pregabalin on Post-operative Pain and Opioid Consumption in Spine Surgery, a Prospective, Randomized, Controlled Study[NCT05083793] | Phase 2 | 90 participants (Anticipated) | Interventional | 2020-04-01 | Enrolling by invitation | ||
| Estrogen Receptors Beta (ER-B) as Therapeutic Targets for the Improvement of Cognitive Performance in Fragile-X (TESXF)[NCT01855971] | Phase 2 | 44 participants (Actual) | Interventional | 2013-06-11 | Completed | ||
| Exploratory Study on the Use of Pregabalin for the Treatment of Taxol Related Arthralgia-Myalgia[NCT02024568] | Phase 2 | 38 participants (Anticipated) | Interventional | 2013-12-31 | Not yet recruiting | ||
| Bridging Cognitive Aging in Rodents to Man Using fMRI in Amnestic MCI[NCT01044758] | Phase 2 | 96 participants (Actual) | Interventional | 2009-12-31 | Completed | ||
| Network-Level Mechanisms for Preclinical Alzheimer's Disease Development[NCT03461861] | Phase 2 | 26 participants (Actual) | Interventional | 2019-04-11 | Completed | ||
| Levetiracetam for Alzheimer's Disease Neuropsychiatric Symptoms Related to Epilepsy Trial (LAPSE) - A Phase II Exploratory Study[NCT04004702] | Phase 2 | 65 participants (Anticipated) | Interventional | 2020-01-31 | Not yet recruiting | ||
| Comparison of Oral Lamotrigine Versus Pregabalin for Control of Acute and Chronic Pain Following Modified Radical Mastectomy: Controlled Double-blind Study[NCT03419949] | 0 participants | Expanded Access | Available | ||||
| A Randomized, Placebo-Controlled Pilot Study in Huntington's Disease (CIT-HD)[NCT00271596] | Phase 2 | 33 participants (Actual) | Interventional | 2005-11-30 | Completed | ||
| NMDA-Receptor Blockade in Huntington's Chorea[NCT00001930] | Phase 2 | 25 participants | Interventional | 1999-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Surgical site pain. Scale 0-10, with 0 best and 10 worst (NCT03334903)
Timeframe: 2-3 months after surgery (at 2nd postoperative appointment)
| Intervention | score on 10-point scale (Mean) |
|---|---|
| Standard of Care | 2.26 |
| Postoperative Gabapentin Regimen | 2.46 |
Surgical site pain. Scale 0-10, with 0 best and 10 worst. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).
| Intervention | score on a 10-point scale (Mean) |
|---|---|
| Standard of Care | 3.84 |
| Postoperative Gabapentin Regimen | 3.54 |
Sleep quality. Scale 0-10 with 0 worst and 10 best. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).
| Intervention | score on a 10-point scale (Mean) |
|---|---|
| Standard of Care | 5.73 |
| Postoperative Gabapentin Regimen | 6.38 |
Nausea. Scale 0-10, with 0 best and 10 worst. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).
| Intervention | score on a 10-point scale (Mean) |
|---|---|
| Standard of Care | 0.36 |
| Postoperative Gabapentin Regimen | 0.17 |
Satisfaction. Scale 0-10 with 0 worst and 10 best. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).
| Intervention | score on a 10-point scale (Mean) |
|---|---|
| Standard of Care | 7.83 |
| Postoperative Gabapentin Regimen | 8.48 |
Number of days until patients are finished consuming opioid medications after discharge. (NCT03334903)
Timeframe: 2-3 months following surgery (measured at second postoperative appointment).
| Intervention | days (Mean) |
|---|---|
| Standard of Care | 14.8 |
| Postoperative Gabapentin Regimen | 18.7 |
Mean opioid consumption, measured in mg of morphine equivalents. (NCT03334903)
Timeframe: 2-3 months following surgery (total amount measured at second postoperative appointment; means assessed afterwards).
| Intervention | morphine equivalents (Mean) |
|---|---|
| Standard of Care | 287.0 |
| Postoperative Gabapentin Regimen | 281.1 |
The Brief Assessment of Cognition in Schizophrenia (BACS) is the metric used to characterize cognition in this study. The BACS consists of 6 subscales: Verbal Memory (range 0-75), Working Memory (range 0-28), Motor Speed (range 0-100), Verbal Fluency (measure is total number of words generated in two 60 second trials), Attention and Processing speed (range 0-110), and Executive Function (range 0-22). For each subscale, higher scores reflect better cognition. For each subscale, a Standard Deviation Score was calculated based on normative data (Keefe et al. Norms and standardization of the Brief Assessment of Cognition in Schizophrenia (BACS). Schizophrenia Research 102 (2008) 108-115). The BACS composite score is calculated as the average Standard Deviation Score of the 6 subscale scores. The change in BACS composite score was calculated as the BACS composite score at 8 weeks minus the BACS composite score at baseline. (NCT01696929)
Timeframe: Change in BACS composite score from baseline to 8 weeks
| Intervention | Change in BACS Composite Score (Mean) |
|---|---|
| Tocilizumab | 0.7 |
The Positive and Negative Symptoms Scale (PANSS) is the metric used to characterize psychotic symptoms in this study. The PANSS consists of 30 items, each scored 1-7. The range for the PANSS total score is 30-210. There are 3 subscales - PANSS positive score (range 7-49), PANSS negative score (range 7-49), and PANSS general score (range 16-112). PANSS total score is the summation of these 3 subscales. Higher values for the total and subscale scores reflect more severe psychopathology. A positive change in PANSS total score reflects an increase in psychopathology. A negative change in PANSS total score reflects a decrease in psychopathology. (NCT01696929)
Timeframe: Change in PANSS total score from baseline to 8 weeks
| Intervention | Change in PANSS Total Score (Mean) |
|---|---|
| Tocilizumab | -2.6 |
"Caregiver-rated Impression of Change (CIC): 7-point scale requiring the caregiver to rate how much the patient's illness has improved or worsened relative to the baseline state.~7-point Likert-type scale for which ratings range from 1 = very much improved to 7 = very much worse, with 4 = no change. This caregiver-rated measure considered activities, behavior, mood and functioning. This rating was performed in consultation with the study Investigator but was based largely on the caregivers' evaluation during the reporting period. The single rating of the CIC was to be based on changes in the following domains: • Activities (watching TV, interest in conversations around her, cooperation during toileting, dressing/bathing, etc.), • Communication (verbal or by eye movements, hand movements, or head movements), • Behavior (agitation, refusal to feed, scratching, social avoidance), • Participation in family/outdoor/social events)" (NCT02790034)
Timeframe: 24 weeks
| Intervention | score on a scale (Mean) |
|---|---|
| Sarizotan Low Dose | 3.6 |
| Sarizotan High Dose | 3.5 |
| Placebo | 3.4 |
Measured as the percent change in the number of apnea episodes per hour during awake time, calculated using an ambulatory data acquisition system (BioRadioTM) as part of home monitoring procedure. BioRadioTM record specific respiratory and cardiac parameters. (NCT02790034)
Timeframe: Baseline up to week 24
| Intervention | % of change in mean counts per hr (Least Squares Mean) |
|---|---|
| Sarizotan Low Dose | 1.54 |
| Sarizotan High Dose | 13.211 |
| Placebo | 18.503 |
Mnemonic similarity task which assesses long term memory function. Scale ranges from 0-100 with higher scores indicating better memory performance. (NCT01044758)
Timeframe: 2 weeks
| Intervention | percent correct recalled (Mean) |
|---|---|
| aMCI_62.5 | 38 |
| aMCI_62.5 Placebo | 33 |
| aMCI_125 | 33 |
| aMCI_125 Placebo | 28 |
| aMCI_250 | 34 |
| aMCI_250 Placebo | 31 |
| Age Matched Control | 44 |
Measurement of average brain activity in the dentate gyrus / CA3 subregion of the hippocampus measured with BOLD functional MRI in patients with mild cognitive impairment on placebo and on drug compared to average brain activity in this brain area in control subjects. (NCT01044758)
Timeframe: 2 weeks
| Intervention | mean beta coefficient (Mean) |
|---|---|
| aMCI_62.5 | -0.1203 |
| aMCI_62.5 Placebo | 0.4353 |
| aMCI_125 | -0.2238 |
| aMCI_125 Placebo | 0.8814 |
| aMCI_250 | 0.3928 |
| aMCI_250 Placebo | 0.4825 |
| Age Matched Control | -.02507 |
The seed-based functional connectivity strengths of the hippocampus network and the default mode network will be employed to measure the changes between AGB101 and Placebo perturbation. The functional connectivity strengths will be measured with the median of the Pearson cross-correlation coefficients over entire brain regions. (NCT03461861)
Timeframe: 2 weeks after treatment between AGB101 and Placebo
| Intervention | Pearson coefficient (Median) |
|---|---|
| AGB101 220 mg | 0.233 |
| Placebo | 0.318 |
Rey Auditory Verbal Learning Test (AVLT), delayed recall Scaled integer will be employed to measure the episodic memory changes before and after AGB101 treatment. The AVLT score will be recorded as a standard score. The theoretical range: min 50, max 155, the higher the better. The higher the number is, the better the memory. It is an integer number. (NCT03461861)
Timeframe: Placebo vs AGB101 2 weeks after treatment paired t-test
| Intervention | score on a scale (Mean) |
|---|---|
| AGB101 220 mg | 108 |
| Placebo | 105 |
Full Scale Name: The Executive Composite Score (ECS). Definition: Subscales were averaged to compute this composite total score. The ECS is the weighted average of performance on 6 subtests of executive function, including (1) the Controlled Oral Word Association Test, (2) Symbol Digit Modalities test; (3) Stroop Color Word Test (Interference Trial), (4) Trail Making test (Part B), (5) Letter-Number Sequencing, and (6) Animal Naming. Construct Measured: Thinking tasks involving planning, working memory, attention, problem solving, verbal reasoning, inhibition, mental flexibility, and task switching. ECS Scale Range: The ECS score ranges from -5 to +5 on a standardized (Z) score scale, where lower scores indicate poorer performance on executive functioning tasks. Change Calculation Details: Compares change in executive functioning performance from visit 2 (week 0) to the weighted average of visits 5 (week 12) & 6 (week 15) for the citalopram versus placebo cohort. (NCT00271596)
Timeframe: after 15 weeks of treatment
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Citalopram | 0.005 |
| Placebo | 0.172 |
Full Scale Name: Hamilton Rating Scale for Depression (HAM-D). Definition: The Hamilton Rating Scale for Depression is a clinician-administered multiple item questionnaire used to provide an indication of depression. Construct Measured: Depression. HAM-D Score Range: Raw scores may range from 0 to 54, where higher scores indicate worsening mood. Change Calculation Details: Compares change in mood from screening (intake visit) to visit 6 (week 15) for the citalopram versus placebo cohort. (NCT00271596)
Timeframe: after 15 weeks of treatment
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Citalopram | -0.67 |
| Placebo | 1.23 |
Full Scale Name: Letter Number Sequencing (LNS) subtest from the Wechsler Adult Intelligence Scale (WAIS) third edition. Definition: LNS is a task that requires the reordering of an initially unordered set of letters and numbers. Construct Measured: Working memory. LNS Score Range: Raw scores may range from 0 to 21, where lower scores indicate poorer performance in working memory. Change Calculation Details: Compares change in working memory performance from visit 2 (week 0) to the weighted average of visits 5 (week 12) & 6 (week 15) for the citalopram versus placebo cohort. (NCT00271596)
Timeframe: after 15 weeks of treatment
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Citalopram | -0.113 |
| Placebo | 0.225 |
Semantic Fluency Score. Definition: The Semantic Fluency Score is the number of words a person can produce given a category, including naming (1) Animal names, (2) Fruit names, (3) Boy names, (4) Girl names, and (5) Vegetable names. Construct Measured: Working memory and verbal initiation. Scale Range: The Semantic Fluency Score ranges from -5 to +5 on a standardized (Z) score scale, where lower scores indicate poorer performance on working memory tasks. Change Calculation Details: Compares change in working memory performance from visit 2 (week 0) where patients named fruit names to the weighted average of visits 5 (week 12) & 6 (week 15) where patients named girl names and vegetable names respectively for the citalopram versus placebo cohort. (NCT00271596)
Timeframe: after 15 weeks of treatment
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Citalopram | 0.386 |
| Placebo | 0.664 |
"Full Scale Name: Stroop Interference subtest from The Stroop Color and Word Test. Definition: Participants are asked to name the ink color in which a word is printed when the word itself (which is irrelevant to the task) is the name of a different color rather than the same color. For example, participants may be asked to say red to the word blue printed in red ink. Constructs Measured: Selective attention, response inhibition, cognitive flexibility, and processing speed. Scale Range: The Stroop Interference score ranges from -5 to +5 on a standardized (Z) score scale, where lower scores indicate poorer performance. Change Calculation Details: Compares change in attention and processing speed performance from visit 2 (week 0) to the weighted average of visits 5 (week 12) and 6 (week 15) for the citalopram versus placebo cohort." (NCT00271596)
Timeframe: after 15 weeks of treatment
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Citalopram | -0.256 |
| Placebo | -0.046 |
Full Scale Name: Hamilton Rating Scale for Depression (HAM-D). Definition: The Hamilton Rating Scale for Depression is a clinician-administered multiple item questionnaire used to provide an indication of depression. Construct Measured: Depression. HAM-D Score Range: Raw scores may range from 0 to 54, where higher scores indicate worsening mood. Change Calculation Details: This analysis was restricted to a subgroup and, accordingly, does not reflect the total number of participants as reported in the Participant Flow. This analysis compares change in mood from screening (intake visit) to visit 6 (week 15) for the citalopram versus placebo cohort. (NCT00271596)
Timeframe: after 15 weeks of treatment
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Citalopram | -0.10 |
| Placebo | 1.50 |
Full Scale Name: The Symbol Digit Modalities Test (SDMT). Definition: The SDMT screens for organic cerebral dysfunction by having the examinee use a reference key to pair specific numbers with given geometric figures in 90 seconds. Construct Measured: Attention, processing speed, and working memory. SDMT Scale Range: Raw scores may range from 0 to 110, where lower scores indicate poorer performance. Change Calculation Details: Compares change in performance from visit 2 (week 0) to the weighted average of visits 5 (week 12) & 6 (week 15) for the citalopram versus placebo cohort. (NCT00271596)
Timeframe: after 15 weeks of treatment
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Citalopram | -0.227 |
| Placebo | -0.170 |
Full Scale Name: The Total Functional Capacity (TFC) subscale from the Unified Huntington's Disease Rating Scale (UHDRS). Definition: The TFC is a score that classifies five stages of Huntington's Disease and five levels of function in the domains of workplace, finances, domestic chores, activities of daily living and requirements for unskilled or skilled care. Construct Measured: Activities of Daily Living. Scale Range: The TFC score ranges from 0 to 13, where lower scores indicate poorer performance in activities of daily living. Change Calculation Details: Compares change in TFC performance from Baseline (week -4) to the weighted average of visits 4 (week 6) and 6 (week 15) for the citalopram versus placebo cohort. (NCT00271596)
Timeframe: after 15 weeks of treatment
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Citalopram | -0.54 |
| Placebo | -0.06 |
"Full Scale Name: Trail Making Test Part B (TMT-B). Definition: The TMT-B test requires participants to connect-the-dots of 25 consecutive targets on a sheet of paper where the subject alternates between numbers and letters, going in both numerical and alphabetical order. Constructs Measured: Attention, set shifting, and processing speed. Scale range: The TMT-B score ranges from -5 to +5 on a standardized (Z) score scale, where lower scores indicate poorer performance. Change Calculation Details: Compares change in attention and processing speed performance from visit 2 (week 0) to the weighted average of visits 5 (week 12) and 6 (week 15) for the citalopram versus placebo cohort." (NCT00271596)
Timeframe: after 15 weeks of treatment
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Citalopram | 0.087 |
| Placebo | 0.405 |
Full Scale Name: The Verbal Fluency Score (VFC). Definition: The VFC is the number of words a person can produce given a letter, including (1) Naming words that start with F, A, and S; (2) naming words that start with K, W, and R; (3) naming words that start with V, I, and P; (4) naming words that start with O, G, and B; (5) naming words that start with E, N, and T; and (6) naming words that start with J, C, and S. Construct Measured: Verbal initiation and flexibility. Scale Range: The Verbal Fluency Composite Score ranges from -5 to +5 on a standardized (Z) score scale, where lower scores indicate poorer performance. Change Calculation Details: Compares change in verbal initiation and flexibility from visit 2 (week 0) where patients named words starting with O, G, and B to the weighted average of visits 5 (week 12) and 6 (week 15) where patients named words starting with E, N, and T, and J, C, and S respectively for the citalopram versus placebo cohort. (NCT00271596)
Timeframe: after 15 weeks of treatment
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Citalopram | 0.140 |
| Placebo | 0.071 |
148 reviews available for gamma-aminobutyric acid and Disease Models, Animal
| Article | Year |
|---|---|
Review on Cross Talk between Neurotransmitters and Neuroinflammation in Striatum and Cerebellum in the Mediation of Motor Behaviour.
Topics: Animals; Astrocytes; Central Nervous System; Cerebellum; Corpus Striatum; Cytokines; Disease Models, | 2019 |
Succinic Semialdehyde Dehydrogenase Deficiency: An Update.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Animals; Child; Clinical Trials as Topic; Developmental | 2020 |
Benefits of animal models to understand the pathophysiology of depressive disorders.
Topics: Animals; Antidepressive Agents; Biomarkers; Depressive Disorder, Major; Disease Models, Animal; gamm | 2021 |
Valproic Acid and Propionic Acid Modulated Mechanical Pathways Associated with Autism Spectrum Disorder at Prenatal and Neonatal Exposure.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Female; Food Preservati | 2022 |
Neural mechanisms underlying GABAergic regulation of adult hippocampal neurogenesis.
Topics: Adult; Animals; Central Nervous System Diseases; Dentate Gyrus; Disease Models, Animal; GABAergic Ne | 2018 |
Plasticity of the epigenome during early-life stress.
Topics: Age Factors; Animals; Brain-Derived Neurotrophic Factor; Disease Models, Animal; DNA Methylation; Ep | 2018 |
Inhibition in the amygdala anxiety circuitry.
Topics: Amygdala; Animals; Anxiety; Biomarkers; Disease Models, Animal; GABAergic Neurons; gamma-Aminobutyri | 2018 |
The Dynamics of Neurosteroids and Sex-Related Hormones in the Pathogenesis of Alzheimer's Disease.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Brain; Cell Differentiation; Di | 2018 |
Analgesic mechanisms of gabapentinoids and effects in experimental pain models: a narrative review.
Topics: Analgesics; Animals; Calcium Channels; Disease Models, Animal; Gabapentin; gamma-Aminobutyric Acid; | 2018 |
[A review on the role of γ-aminobutyric acid signaling pathway in autism spectrum disorder].
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; H | 2018 |
Unsupervised excitation: GABAergic dysfunctions in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Disease Models, Animal; GABAergic Neurons; | 2019 |
The Fragile Brain: Stress Vulnerability, Negative Affect and GABAergic Neurocircuits in Psychosis.
Topics: Affect; Amygdala; Animals; Brain; Disease Models, Animal; gamma-Aminobutyric Acid; Hippocampus; Huma | 2019 |
Gene expression profiling as functional readout of rodent models for psychiatric disorders.
Topics: Animals; Brain; Disease Models, Animal; gamma-Aminobutyric Acid; Gene Expression Profiling; Humans; | 2013 |
Glycine receptor mouse mutants: model systems for human hyperekplexia.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Genetic Predisposition to Disease; Glycine | 2013 |
Understanding the sleep-wake cycle: sleep, insomnia, and the orexin system.
Topics: Animals; Benzodiazepines; Brain; Brain Mapping; Circadian Rhythm; Cognitive Behavioral Therapy; Comb | 2013 |
Reducing GABAergic inhibition restores cognitive functions in a mouse model of Down syndrome.
Topics: Animals; Cognition Disorders; Disease Models, Animal; Down Syndrome; GABA Agents; gamma-Aminobutyric | 2014 |
Immunology of stiff person syndrome and other GAD-associated neurological disorders.
Topics: Animals; Autoantibodies; Autoantigens; Autoimmune Diseases of the Nervous System; Biomarkers; Diseas | 2013 |
The GAD65 knock out mouse - a model for GABAergic processes in fear- and stress-induced psychopathology.
Topics: Amygdala; Animals; Anxiety Disorders; Disease Models, Animal; Fear; gamma-Aminobutyric Acid; Glutama | 2015 |
Clozapine and GABA transmission in schizophrenia disease models: establishing principles to guide treatments.
Topics: Animals; Antipsychotic Agents; Brain; Clozapine; Disease Models, Animal; gamma-Aminobutyric Acid; Sc | 2015 |
Building models for postmortem abnormalities in hippocampus of schizophrenics.
Topics: Action Potentials; Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Hippocampus; Humans; In | 2015 |
The balancing act of GABAergic synapse organizers.
Topics: Animals; Brain; Disease Models, Animal; GABA Agents; gamma-Aminobutyric Acid; Humans; Neurons; Synap | 2015 |
The Impact of Exposure to Cannabinoids in Adolescence: Insights From Animal Models.
Topics: Adolescent; Animals; Brain; Cannabinoids; Cognition; Disease Models, Animal; Endocannabinoids; gamma | 2016 |
Interneuron Transplantation as a Treatment for Epilepsy.
Topics: Animals; Brain; Disease Models, Animal; Drug Resistant Epilepsy; gamma-Aminobutyric Acid; Humans; In | 2015 |
GABAergic Synchronization in Epilepsy.
Topics: Action Potentials; Animals; Anticonvulsants; Cortical Synchronization; Disease Models, Animal; Epile | 2016 |
Chemotherapy-induced painful neuropathy: pain-like behaviours in rodent models and their response to commonly used analgesics.
Topics: Amines; Analgesics, Opioid; Animals; Antidepressive Agents; Antineoplastic Agents; Cisplatin; Cycloh | 2016 |
Gene Targeting Studies of Hyperexcitability and Affective States of Alcohol Withdrawal in Rodents.
Topics: Alcoholism; Animals; Animals, Genetically Modified; Disease Models, Animal; Epilepsy; gamma-Aminobut | 2016 |
GABAergic Microcircuits in Alzheimer's Disease Models.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Humans; Neurons | 2017 |
Benefit of combination therapy in epilepsy: a review of the preclinical evidence with levetiracetam.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Interact | 2009 |
A psychobiological framework of the substrates that mediate nicotine use during adolescence.
Topics: Adolescent; Age Factors; Animals; Brain Chemistry; Disease Models, Animal; Dopamine; gamma-Aminobuty | 2009 |
[Photosensitive epilepsy in Papio papio. A model of photosensitive epilepsy in humans].
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Epilepsies, Myoclonic; Epi | 1973 |
Epilepsy following cortical injury: cellular and molecular mechanisms as targets for potential prophylaxis.
Topics: Animals; Anticonvulsants; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Epilepsy, Post-Tr | 2009 |
Transplantation of GABA-producing cells for seizure control in models of temporal lobe epilepsy.
Topics: Animals; Brain Tissue Transplantation; Disease Models, Animal; Epilepsy, Temporal Lobe; gamma-Aminob | 2009 |
The epileptic hypothesis: developmentally related arguments based on animal models.
Topics: Age Factors; Animals; Brain; Child, Preschool; Cognition Disorders; Developmental Disabilities; Dise | 2009 |
Molecular mechanisms underlying glutamatergic dysfunction in schizophrenia: therapeutic implications.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Interneurons; Model | 2009 |
Angelman syndrome: current understanding and research prospects.
Topics: Angelman Syndrome; Animals; Brain; Cerebellum; Chromosomes, Human, Pair 15; D-Aspartic Acid; Dendrit | 2009 |
Experimental status epilepticus in animals: What are we modeling?
Topics: Animals; Brain; Convulsants; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Humans; Neur | 2009 |
Neuronal plasticity in animal models and the epileptic human hippocampus.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; gamma-Aminobutyri | 2009 |
Brain angiotensin peptides regulate sympathetic tone and blood pressure.
Topics: Angiotensin II; Animals; Blood Pressure; Brain; Disease Models, Animal; gamma-Aminobutyric Acid; Glu | 2010 |
Biochemical and anatomical substrates of depression and sickness behavior.
Topics: Adenosine; Adrenergic Uptake Inhibitors; Animals; Basal Ganglia; Brain; Depression; Disease Models, | 2010 |
In vivo experimental models of epilepsy.
Topics: Aluminum Hydroxide; Animals; Bicuculline; Cobalt; Convulsants; Disease Models, Animal; Electroshock; | 2010 |
Succinic semialdehyde dehydrogenase: biochemical-molecular-clinical disease mechanisms, redox regulation, and functional significance.
Topics: Aldehydes; Amino Acid Metabolism, Inborn Errors; Animals; Catalytic Domain; Developmental Disabiliti | 2011 |
[Pregabalin and postoperative hyperalgesia. A review].
Topics: Analgesics; Animals; Calcium Channels; Disease Models, Animal; gamma-Aminobutyric Acid; Humans; Hype | 2011 |
[Development of animal models of herpetic pain and postherpetic neuralgia and elucidation of the mechanisms of the onset and inhibition of allodynia].
Topics: Amines; Analgesics; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Cyclooxygenase Inhibitors | 2011 |
Postnatal developmental trajectories of neural circuits in the primate prefrontal cortex: identifying sensitive periods for vulnerability to schizophrenia.
Topics: Adolescent; Adolescent Development; Age of Onset; Animals; Disease Models, Animal; gamma-Aminobutyri | 2011 |
GABAergic depolarization during early cortical development and implications for anticonvulsive therapy in neonates.
Topics: Animals; Animals, Newborn; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; Epilepsy; gamma | 2011 |
Autism: a "critical period" disorder?
Topics: Animals; Autistic Disorder; Brain; Critical Period, Psychological; Disease Models, Animal; gamma-Ami | 2011 |
Amygdala regulation of fear and emotionality in fragile X syndrome.
Topics: Amygdala; Animals; Conditioning, Psychological; Disease Models, Animal; Emotions; Fear; Fragile X Sy | 2011 |
GABA neuron alterations, cortical circuit dysfunction and cognitive deficits in schizophrenia.
Topics: Animals; Biological Clocks; Cerebral Cortex; Cognition Disorders; Cortical Synchronization; Disease | 2011 |
Fragile X syndrome: the GABAergic system and circuit dysfunction.
Topics: Amygdala; Animals; Cerebral Cortex; Disease Models, Animal; Fragile X Mental Retardation Protein; Fr | 2011 |
GABAergic transmission in temporal lobe epilepsy: the role of neurosteroids.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Humans; Ne | 2013 |
Genes and molecular mechanisms involved in the epileptogenesis of idiopathic absence epilepsies.
Topics: Adolescent; Alleles; Animals; Calcium Channels; Child; Disease Models, Animal; Epilepsy, Absence; ga | 2012 |
Methylmercury: a potential environmental risk factor contributing to epileptogenesis.
Topics: Animals; Disease Models, Animal; Disease Susceptibility; Environmental Exposure; Epilepsy; gamma-Ami | 2012 |
Consensus paper: pathological role of the cerebellum in autism.
Topics: Animals; Autistic Disorder; Cell Adhesion Molecules, Neuronal; Cerebellar Diseases; Cerebellum; Cogn | 2012 |
Does interictal synchronization influence ictogenesis?
Topics: Animals; Disease Models, Animal; Electroencephalography Phase Synchronization; Epilepsy, Temporal Lo | 2013 |
[Petit-mal epilepsy in laboratory rats, issues that an experimenter should be remember].
Topics: Animals; Disease Models, Animal; Electroencephalography; Energy Metabolism; Epilepsy, Absence; Evoke | 2002 |
Basic pharmacology of valproate: a review after 35 years of clinical use for the treatment of epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dopamine; Epilepsy; Excitatory Amino Acids; gamma- | 2002 |
Functional and morphological changes in the hippocampal neuronal circuits associated with epileptic seizures.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Electrophysiology; Excitatory Postsynaptic Potential | 2002 |
Central GABAergic systems and depressive illness.
Topics: Animals; Antidepressive Agents; Brain; Depressive Disorder; Disease Models, Animal; gamma-Aminobutyr | 2003 |
Cellular and molecular action of the putative GABA-mimetic, gabapentin.
Topics: Acetates; Amines; Analgesics; Animals; Anticonvulsants; Anxiety; Brain; Cyclohexanecarboxylic Acids; | 2003 |
Inhibition of gamma-aminobutyric acid uptake: anatomy, physiology and effects against epileptic seizures.
Topics: Animals; Carrier Proteins; Disease Models, Animal; Epilepsy; GABA Antagonists; GABA Plasma Membrane | 2003 |
Progress in pursuit of therapeutic A2A antagonists: the adenosine A2A receptor selective antagonist KW6002: research and development toward a novel nondopaminergic therapy for Parkinson's disease.
Topics: Adenosine A2 Receptor Antagonists; Animals; Antiparkinson Agents; Clinical Trials as Topic; Corpus S | 2003 |
[Neuroprotection in brain ischemia--doubts and hopes].
Topics: Animals; Apoptosis; Brain Ischemia; Calcium Channels; Cerebrovascular Circulation; Clinical Trials a | 2004 |
Calcium binding protein markers of GABA deficits in schizophrenia--postmortem studies and animal models.
Topics: Animals; Biomarkers; Calcium-Binding Proteins; Disease Models, Animal; gamma-Aminobutyric Acid; Huma | 2004 |
Pregabalin pharmacology and its relevance to clinical practice.
Topics: Animals; Anticonvulsants; Biological Availability; Calcium Channels; Clinical Trials as Topic; Disea | 2004 |
Pregabalin pharmacology and its relevance to clinical practice.
Topics: Animals; Anticonvulsants; Biological Availability; Calcium Channels; Clinical Trials as Topic; Disea | 2004 |
Pregabalin pharmacology and its relevance to clinical practice.
Topics: Animals; Anticonvulsants; Biological Availability; Calcium Channels; Clinical Trials as Topic; Disea | 2004 |
Pregabalin pharmacology and its relevance to clinical practice.
Topics: Animals; Anticonvulsants; Biological Availability; Calcium Channels; Clinical Trials as Topic; Disea | 2004 |
Pregabalin pharmacology and its relevance to clinical practice.
Topics: Animals; Anticonvulsants; Biological Availability; Calcium Channels; Clinical Trials as Topic; Disea | 2004 |
Pregabalin pharmacology and its relevance to clinical practice.
Topics: Animals; Anticonvulsants; Biological Availability; Calcium Channels; Clinical Trials as Topic; Disea | 2004 |
Pregabalin pharmacology and its relevance to clinical practice.
Topics: Animals; Anticonvulsants; Biological Availability; Calcium Channels; Clinical Trials as Topic; Disea | 2004 |
Pregabalin pharmacology and its relevance to clinical practice.
Topics: Animals; Anticonvulsants; Biological Availability; Calcium Channels; Clinical Trials as Topic; Disea | 2004 |
Pregabalin pharmacology and its relevance to clinical practice.
Topics: Animals; Anticonvulsants; Biological Availability; Calcium Channels; Clinical Trials as Topic; Disea | 2004 |
Pregabalin pharmacology and its relevance to clinical practice.
Topics: Animals; Anticonvulsants; Biological Availability; Calcium Channels; Clinical Trials as Topic; Disea | 2004 |
Pregabalin pharmacology and its relevance to clinical practice.
Topics: Animals; Anticonvulsants; Biological Availability; Calcium Channels; Clinical Trials as Topic; Disea | 2004 |
Pregabalin pharmacology and its relevance to clinical practice.
Topics: Animals; Anticonvulsants; Biological Availability; Calcium Channels; Clinical Trials as Topic; Disea | 2004 |
Pregabalin pharmacology and its relevance to clinical practice.
Topics: Animals; Anticonvulsants; Biological Availability; Calcium Channels; Clinical Trials as Topic; Disea | 2004 |
Pregabalin pharmacology and its relevance to clinical practice.
Topics: Animals; Anticonvulsants; Biological Availability; Calcium Channels; Clinical Trials as Topic; Disea | 2004 |
Pregabalin pharmacology and its relevance to clinical practice.
Topics: Animals; Anticonvulsants; Biological Availability; Calcium Channels; Clinical Trials as Topic; Disea | 2004 |
Pregabalin pharmacology and its relevance to clinical practice.
Topics: Animals; Anticonvulsants; Biological Availability; Calcium Channels; Clinical Trials as Topic; Disea | 2004 |
Pregabalin pharmacology and its relevance to clinical practice.
Topics: Animals; Anticonvulsants; Biological Availability; Calcium Channels; Clinical Trials as Topic; Disea | 2004 |
Pregabalin pharmacology and its relevance to clinical practice.
Topics: Animals; Anticonvulsants; Biological Availability; Calcium Channels; Clinical Trials as Topic; Disea | 2004 |
Pregabalin pharmacology and its relevance to clinical practice.
Topics: Animals; Anticonvulsants; Biological Availability; Calcium Channels; Clinical Trials as Topic; Disea | 2004 |
Pregabalin pharmacology and its relevance to clinical practice.
Topics: Animals; Anticonvulsants; Biological Availability; Calcium Channels; Clinical Trials as Topic; Disea | 2004 |
Pregabalin pharmacology and its relevance to clinical practice.
Topics: Animals; Anticonvulsants; Biological Availability; Calcium Channels; Clinical Trials as Topic; Disea | 2004 |
Pregabalin pharmacology and its relevance to clinical practice.
Topics: Animals; Anticonvulsants; Biological Availability; Calcium Channels; Clinical Trials as Topic; Disea | 2004 |
Pregabalin pharmacology and its relevance to clinical practice.
Topics: Animals; Anticonvulsants; Biological Availability; Calcium Channels; Clinical Trials as Topic; Disea | 2004 |
Pregabalin pharmacology and its relevance to clinical practice.
Topics: Animals; Anticonvulsants; Biological Availability; Calcium Channels; Clinical Trials as Topic; Disea | 2004 |
Pregabalin pharmacology and its relevance to clinical practice.
Topics: Animals; Anticonvulsants; Biological Availability; Calcium Channels; Clinical Trials as Topic; Disea | 2004 |
Murine succinate semialdehyde dehydrogenase (SSADH) deficiency, a heritable disorder of GABA metabolism with epileptic phenotype.
Topics: Animals; Disease Models, Animal; Epilepsy, Absence; gamma-Aminobutyric Acid; Humans; Metabolism, Inb | 2005 |
Tinnitus: neurobiological substrates.
Topics: Animals; Calcium; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Humans; N | 2005 |
Role of paraventricular nucleus in mediating sympathetic outflow in heart failure.
Topics: Animals; Cardiac Output, Low; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Heart; Heart | 2000 |
Autism: neuropathology, alterations of the GABAergic system, and animal models.
Topics: Animals; Autistic Disorder; Brain; Disease Models, Animal; gamma-Aminobutyric Acid; Humans | 2005 |
Reelin down-regulation in mice and psychosis endophenotypes.
Topics: Animals; Behavior, Animal; Brain; Cell Adhesion Molecules, Neuronal; Disease Models, Animal; Down-Re | 2006 |
Alcohol-related genes: contributions from studies with genetically engineered mice.
Topics: Alcoholism; Animals; Corticotropin-Releasing Hormone; Disease Models, Animal; gamma-Aminobutyric Aci | 2006 |
Current concepts in neuroendocrine cancer metabolism.
Topics: Animals; Autocrine Communication; Biomarkers, Tumor; Catecholamines; Disease Models, Animal; gamma-A | 2006 |
Role of GABA in anxiety and depression.
Topics: Animals; Anxiety Disorders; Brain; Depressive Disorder; Diagnostic Imaging; Disease Models, Animal; | 2007 |
Pharmacology and mechanism of action of pregabalin: the calcium channel alpha2-delta (alpha2-delta) subunit as a target for antiepileptic drug discovery.
Topics: Amines; Amino Acid Sequence; Animals; Anticonvulsants; Calcium Channels; Cyclohexanecarboxylic Acids | 2007 |
Rat modeling for GABA defects in schizophrenia.
Topics: Animals; Brain; Disease Models, Animal; gamma-Aminobutyric Acid; Humans; Long-Term Potentiation; Pro | 2006 |
Anesthetic-mediated protection/preconditioning during cerebral ischemia.
Topics: Anesthetics, Inhalation; Animals; Brain; Brain Ischemia; Disease Models, Animal; gamma-Aminobutyric | 2007 |
[A new aspect in the research on antiepileptic drugs].
Topics: Acetamides; Amines; Animals; Anticonvulsants; Benzodiazepines; Carbamates; Cyclohexanecarboxylic Aci | 2007 |
Advances in the pathophysiology of status epilepticus.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Humans; Neurons; Receptors, GABA; Status E | 2007 |
Cell therapy in models for temporal lobe epilepsy.
Topics: Acetylcholine; Adenosine; Animals; Cell Transplantation; Disease Models, Animal; Epilepsy, Temporal | 2007 |
Neonatal seizures: gaps between the laboratory and the clinic.
Topics: Animals; Brain; Cognition Disorders; Cohort Studies; Disease Models, Animal; Electroencephalography; | 2007 |
The role of hippocampus in the pathophysiology of bipolar disorder.
Topics: Animals; Antimanic Agents; Bipolar Disorder; Disease Models, Animal; gamma-Aminobutyric Acid; Glutam | 2007 |
Modelling prefrontal cortex deficits in schizophrenia: implications for treatment.
Topics: Animals; Antipsychotic Agents; Disease Models, Animal; Excitatory Amino Acid Antagonists; gamma-Amin | 2008 |
The multifaceted role of inhibition in epilepsy: seizure-genesis through excessive GABAergic inhibition in autosomal dominant nocturnal frontal lobe epilepsy.
Topics: Animals; Chromosome Disorders; Chronobiology Disorders; Disease Models, Animal; Epilepsy, Frontal Lo | 2008 |
On the sacred disease: the neurochemistry of epilepsy.
Topics: Acetylcholine; Amino Acids; Animals; Anticonvulsants; Brain; Catecholamines; Convulsants; Disease Mo | 1983 |
Neurotransmitter specific alterations in dementing disorders: insights from animal models.
Topics: Alzheimer Disease; Animals; Brain; Cats; Cerebral Cortex; Cholinergic Fibers; Dementia; Disease Mode | 1984 |
[Toxic action of kainic acid as a model of Huntington chorea and epilepsy (review)].
Topics: Animals; Anticonvulsants; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Drug Interactio | 1983 |
GABA-agonists as anti-epileptic agents.
Topics: Animals; Anticonvulsants; Barbiturates; Benzodiazepines; Disease Models, Animal; Epilepsy; Etomidate | 1981 |
Reflections on experimental and human pathology of aggression.
Topics: Aggression; Animals; Brain; Diet; Disease Models, Animal; Dopamine; Emotions; gamma-Aminobutyric Aci | 1984 |
Learned helplessness and animal models of depression.
Topics: Affect; Animals; Antidepressive Agents; Association; Brain; Cognition; Depressive Disorder; Disease | 1984 |
Depletion of dopamine in the striatum as an experimental model of Parkinsonism: direct effects and adaptive mechanisms.
Topics: Adenylyl Cyclases; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Antagonists; | 1982 |
A theory of schizophrenia: role of environment.
Topics: Aggression; Animals; Brain Chemistry; Disease Models, Animal; Environment; gamma-Aminobutyric Acid; | 1982 |
[Approaches to drug therapy of alcoholism].
Topics: Alcohol Deterrents; Alcoholism; Animals; Catecholamines; Disease Models, Animal; Drug Evaluation, Pr | 1982 |
The role of the inferior colliculus in a genetic model of audiogenic seizures.
Topics: Acoustic Stimulation; Animals; Disease Models, Animal; Disease Susceptibility; Epilepsy; gamma-Amino | 1995 |
The role of endogenous benzodiazepines in hepatic encephalopathy: animal studies.
Topics: Animals; Benzodiazepines; Disease Models, Animal; gamma-Aminobutyric Acid; Hepatic Encephalopathy; R | 1993 |
Interneurons in rat hippocampus after cerebral ischemia. Morphometric, functional, and therapeutic investigations.
Topics: Animals; Autoradiography; Brain Ischemia; Calcium-Binding Proteins; Cell Death; Cholecystokinin; Dis | 1993 |
[Neurochemical approach to epilepsy].
Topics: Animals; Brain; Disease Models, Animal; Epilepsy; Female; gamma-Aminobutyric Acid; Male; Mice; Neuro | 1994 |
Ictal patterns in experimental models of epilepsy.
Topics: Animals; Anticonvulsants; Computer Simulation; Convulsants; Culture Techniques; Disease Models, Anim | 1993 |
Serotonin dysfunction disorders: a behavioral neurochemistry perspective.
Topics: Animals; Antidepressive Agents; Anxiety Disorders; Behavior, Animal; Brain Chemistry; Cognition Diso | 1996 |
Gabapentin.
Topics: Acetates; Adult; Amines; Animals; Anticonvulsants; Child; Clinical Trials as Topic; Cyclohexanecarbo | 1995 |
Vigabatrin.
Topics: Animals; Anticonvulsants; Biological Availability; Child; Clinical Trials as Topic; Disease Models, | 1995 |
Central tinnitus and lateral inhibition: an auditory brainstem model.
Topics: Acoustic Stimulation; Aging; Animals; Auditory Threshold; Cats; Cochlear Nucleus; Disease Models, An | 1996 |
GABA and epilepsy in the photosensitive baboon Papio papio.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; GABA-A Receptor Agonists; GABA-A Recepto | 1996 |
Immunolesion by 192IgG-saporin of rat basal forebrain cholinergic system: a useful tool to produce cortical cholinergic dysfunction.
Topics: Acetylcholine; Acetylcholinesterase; Alzheimer Disease; Animals; Antibodies, Monoclonal; Cerebral Co | 1996 |
The biological basis of schizophrenia: new directions.
Topics: Animals; Aspartic Acid; Brain; Cholecystokinin; Disease Models, Animal; Dopamine; Entorhinal Cortex; | 1997 |
Gabapentin for treatment of epilepsy in children.
Topics: Acetates; Adolescent; Adult; Amines; Animals; Anticonvulsants; Child; Clinical Trials as Topic; Cycl | 1997 |
4-Hydroxybutyric acid and the clinical phenotype of succinic semialdehyde dehydrogenase deficiency, an inborn error of GABA metabolism.
Topics: Aldehyde Oxidoreductases; Animals; Anticonvulsants; Child; Developmental Disabilities; Disease Model | 1998 |
Identification and preclinical testing of novel antiepileptic compounds.
Topics: Adenosine Triphosphatases; Animals; Anticonvulsants; Brain; Cells, Cultured; Clinical Trials as Topi | 1997 |
[GABAergic mechanisms in generalized epilepsies: the neuroanatomical dimension].
Topics: Animals; Central Nervous System; Disease Models, Animal; Epilepsy, Generalized; gamma-Aminobutyric A | 1997 |
Amygdala damage in experimental and human temporal lobe epilepsy.
Topics: Amygdala; Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Humans; | 1998 |
Chronic ethanol consumption: from neuroadaptation to neurodegeneration.
Topics: Acetylcholine; Adaptation, Physiological; Alcohol Amnestic Disorder; Alcohol Drinking; Alcohol-Relat | 1998 |
[Anticonvulsants can aggravate idiopathic generalized epilepsy].
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Epilepsies, Myoclonic; Epilepsy, Ab | 1998 |
GABA and epileptogenesis: comparing gabrb3 gene-deficient mice with Angelman syndrome in man.
Topics: Angelman Syndrome; Animals; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Gene Expressi | 1999 |
[Molecular mechanism underlying epileptic seizure: forwards development of novel drugs for untreatable epilepsy].
Topics: Amidohydrolases; Animals; Anticonvulsants; Aspartic Acid; Brain-Derived Neurotrophic Factor; Cerulop | 1999 |
The GABA-withdrawal syndrome: a model of local status epilepticus.
Topics: Animals; Calcium; Disease Models, Animal; Drug Resistance; Excitatory Postsynaptic Potentials; gamma | 2000 |
Tardive dyskinesia: pathophysiology and animal models.
Topics: Age Factors; Animals; Antipsychotic Agents; Basal Ganglia; Behavior, Animal; Disease Models, Animal; | 2000 |
A noradrenergic and serotonergic hypothesis of the linkage between epilepsy and affective disorders.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Brain Chemistry; Causality; Depression; Disease Mod | 1999 |
Hypothalamus, hypertension, and exercise.
Topics: Animals; Cardiovascular Physiological Phenomena; Disease Models, Animal; gamma-Aminobutyric Acid; Hy | 2000 |
Kainate, a double agent that generates seizures: two decades of progress.
Topics: Animals; Disease Models, Animal; Electric Conductivity; Epilepsy, Temporal Lobe; Excitatory Amino Ac | 2000 |
Cellular abnormalities and synaptic plasticity in seizure disorders of the immature nervous system.
Topics: Age Factors; Animals; Brain; Causality; Cerebral Cortex; Disease Models, Animal; Epilepsy; Excitator | 2000 |
Transplantation in the rat model of Parkinson's disease: ectopic versus homotopic graft placement.
Topics: Animals; Brain Tissue Transplantation; Disability Evaluation; Disease Models, Animal; Dopamine; gamm | 2000 |
Tourette's syndrome: when habit-forming systems form habits of their own?
Topics: Animals; Autoimmunity; Basal Ganglia; Cerebral Cortex; Disease Models, Animal; gamma-Aminobutyric Ac | 2000 |
Mutant mice as a model for cerebellar ataxia.
Topics: Animals; Ataxia; Cerebellar Ataxia; Cerebellum; Disease Models, Animal; gamma-Aminobutyric Acid; Gly | 2001 |
The process of epileptogenesis: a pathophysiological approach.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Glutamic Acid; Hi | 2001 |
Toward an integrative understanding of social phobia.
Topics: Animals; Brain; Disease Models, Animal; gamma-Aminobutyric Acid; Genetic Predisposition to Disease; | 2001 |
GABAergic mechanisms in epilepsy.
Topics: 4-Aminobutyrate Transaminase; Animals; Disease Models, Animal; Epilepsy; GABA Agonists; GABA Antagon | 2001 |
In vivo nuclear magnetic resonance studies of glutamate-gamma-aminobutyric acid-glutamine cycling in rodent and human cortex: the central role of glutamine.
Topics: Acetates; Animals; Astrocytes; Biological Transport; Blood-Brain Barrier; Carbon Isotopes; Cerebral | 2001 |
Dendritic spine hypoplasticity and downregulation of reelin and GABAergic tone in schizophrenia vulnerability.
Topics: Adolescent; Adult; Age of Onset; Animals; Antigens, CD; Bipolar Disorder; Brain; Cell Adhesion Molec | 2001 |
Involvement of gamma-aminobutyric acid in myoclonus.
Topics: Animals; Brain; Disease Models, Animal; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Myoclonus | 2002 |
Photomyoclonic seizures in the baboon, Papio papio.
Topics: Amines; Animals; Anticonvulsants; Behavior, Animal; Benzodiazepinones; Disease Models, Animal; Ethin | 1979 |
[Neurochemical mechanisms of the development of motion sickness].
Topics: Animals; Arginine Vasopressin; Biogenic Amines; Cats; Disease Models, Animal; gamma-Aminobutyric Aci | 1992 |
Modulatory role of GABA receptor subtypes and glutamate receptors in the anticonvulsant effect of barbiturates.
Topics: Animals; Anticonvulsants; Barbiturates; Brain; Culture Techniques; Disease Models, Animal; Epilepsy; | 1992 |
Interrelationship between retinal ischaemic damage and turnover and metabolism of putative amino acid neurotransmitters, glutamate and GABA.
Topics: Amino Acids; Animals; Biological Transport; Disease Models, Animal; gamma-Aminobutyric Acid; Glutama | 1992 |
Scope and contribution of genetic models to an understanding of the epilepsies.
Topics: Animals; Catecholamines; Disease Models, Animal; Epilepsy; Epilepsy, Absence; gamma-Aminobutyric Aci | 1991 |
The spastic mouse. And the search for an animal model of spasticity in human beings.
Topics: Animals; Cerebral Palsy; Disease Models, Animal; Electric Stimulation; gamma-Aminobutyric Acid; Huma | 1990 |
The gabaergic hypothesis of depression.
Topics: Animals; Behavior; Depressive Disorder; Disease Models, Animal; gamma-Aminobutyric Acid; Humans; Syn | 1989 |
GABA and affective disorders.
Topics: Animals; Antidepressive Agents; Disease Models, Animal; gamma-Aminobutyric Acid; Humans; Mood Disord | 1987 |
Progression and generalization of seizure discharge: anatomical and neurochemical substrates.
Topics: Amino Acids; Animals; Anticonvulsants; Basal Ganglia; Brain; Brain Stem; Convulsants; Disease Models | 1988 |
Taurine and related amino acids in seizure disorders--current controversies.
Topics: Amino Acids; Animals; Anticonvulsants; Clinical Trials as Topic; Disease Models, Animal; Epilepsy; g | 1985 |
[Implications of GABAergic synapses in neuropsychiatry].
Topics: 4-Aminobutyrate Transaminase; Animals; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; | 1985 |
The pharmacology of myoclonus.
Topics: 5-Hydroxytryptophan; Adrenocorticotropic Hormone; Animals; Anticonvulsants; Benzodiazepines; Brain; | 1985 |
Hepatic encephalopathy. Experimental studies in a rat model of fulminant hepatic failure.
Topics: Animals; Brain Chemistry; Disease Models, Animal; Evoked Potentials, Visual; gamma-Aminobutyric Acid | 1985 |
Benzodiazepine/barbiturate/GABA receptor-chloride ionophore complex in a genetic model for generalized epilepsy.
Topics: Animals; Anticonvulsants; Barbiturates; Benzodiazepines; Binding Sites; Chlorides; Disease Models, A | 1986 |
[Biochemistry of manic-depressive disorders (III)--Action mechanisms of therapeutic drugs].
Topics: Animals; Antidepressive Agents; Bipolar Disorder; Disease Models, Animal; gamma-Aminobutyric Acid; H | 1988 |
Valproate and myoclonus.
Topics: 5-Hydroxytryptophan; Amino Acids; Animals; Aspartic Acid; Clonazepam; DDT; Disease Models, Animal; F | 1986 |
Contemporary methods in neurocytology and their application to the study of epilepsy.
Topics: Animals; Cerebral Cortex; Disease Models, Animal; Epilepsies, Partial; Epilepsy; Forecasting; gamma- | 1986 |
[GABA and mood disorders].
Topics: 4-Aminobutyrate Transaminase; Animals; Depression; Disease Models, Animal; gamma-Aminobutyric Acid; | 1987 |
Antidepressants and convulsive seizures: clinical, electroencephalographic, and pharmacological aspects.
Topics: Adult; Age Factors; Aged; Animals; Antidepressive Agents; Catecholamines; Computers; Diagnosis, Diff | 1986 |
Kindling mechanisms: current progress on an experimental epilepsy model.
Topics: Action Potentials; Amygdala; Animals; Catecholamines; Disease Models, Animal; Epilepsy; gamma-Aminob | 1986 |
The biochemical basis of the behavioral disorder in the Lesch-Nyhan syndrome.
Topics: Adenine Nucleotides; Animals; Central Nervous System; Child; Child, Preschool; Clonidine; Corpus Str | 1985 |
4 trials available for gamma-aminobutyric acid and Disease Models, Animal
| Article | Year |
|---|---|
Mitochondrial abnormality associates with type-specific neuronal loss and cell morphology changes in the pedunculopontine nucleus in Parkinson disease.
Topics: Aged; Aged, 80 and over; Animals; Cholinergic Neurons; Disease Models, Animal; Female; gamma-Aminobu | 2013 |
Gabapentin activates spinal noradrenergic activity in rats and humans and reduces hypersensitivity after surgery.
Topics: Adrenergic alpha-Antagonists; Amines; Analgesics; Analgesics, Opioid; Animals; Bee Venoms; Behavior, | 2007 |
The potential use of GABA agonists in psychiatric disorders: evidence from studies with progabide in animal models and clinical trials.
Topics: Adjustment Disorders; Animals; Anticonvulsants; Biogenic Amines; Brain; Clinical Trials as Topic; Co | 1983 |
Taurine and related amino acids in seizure disorders--current controversies.
Topics: Amino Acids; Animals; Anticonvulsants; Clinical Trials as Topic; Disease Models, Animal; Epilepsy; g | 1985 |
1440 other studies available for gamma-aminobutyric acid and Disease Models, Animal
| Article | Year |
|---|---|
Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila.
Topics: Animals; Disease Models, Animal; Drosophila; Drosophila Proteins; Drug Evaluation, Preclinical; Fema | 2008 |
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; | 2008 |
A novel metformin derivative, HL010183, inhibits proliferation and invasion of triple-negative breast cancer cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Disease Models, Ani | 2013 |
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Respo | 2017 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Arbutin protects brain against middle cerebral artery occlusion-reperfusion (MCAo/R) injury.
Topics: Animals; Arbutin; Blood-Brain Barrier; Brain; Chromatography, High Pressure Liquid; Disease Models, | 2021 |
MRS-measured glutamate versus GABA reflects excitatory versus inhibitory neural activities in awake mice.
Topics: Animals; Disease Models, Animal; Epilepsies, Myoclonic; Female; GABAergic Neurons; gamma-Aminobutyri | 2022 |
Saturation transfer MRI is sensitive to neurochemical changes in the rat brain due to chronic unpredictable mild stress.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Cerebral Cortex; Chronic Disease | 2021 |
Changes in Locomotor Activity and Oxidative Stress-Related Factors after the Administration of an Amino Acid Mixture by Generation and Age.
Topics: 5-Hydroxytryptophan; Aging; Amino Acids; Animals; Central Nervous System; Disease Models, Animal; ga | 2021 |
NG2 glia-derived GABA release tunes inhibitory synapses and contributes to stress-induced anxiety.
Topics: Animals; Anxiety; Cell Differentiation; Disease Models, Animal; Exocytosis; gamma-Aminobutyric Acid; | 2021 |
Neurotransmitter-stimulated neuron-derived sEVs have opposite effects on amyloid β-induced neuronal damage.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Extracellular Vesicles; g | 2021 |
GABA
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Hippocampus; Methylazoxymethanol Acetate; | 2022 |
GABA
Topics: Acids; Animals; Bicuculline; Caffeine; Cyclohexenes; Disease Models, Animal; Electroencephalography; | 2021 |
Alteration of the α5 GABA receptor and 5HTT lead to cognitive deficits associated with major depressive-like behaviors in a 14-day combined stress rat model.
Topics: Acetylcholinesterase; Animals; Cognition; Corticosterone; Depression; Depressive Disorder, Major; Di | 2023 |
Human Stem Cell-Derived GABAergic Interneurons Establish Efferent Synapses onto Host Neurons in Rat Epileptic Hippocampus and Inhibit Spontaneous Recurrent Seizures.
Topics: Animals; Cells, Cultured; Disease Models, Animal; gamma-Aminobutyric Acid; Hippocampus; Humans; Inte | 2021 |
NAc-VTA circuit underlies emotional stress-induced anxiety-like behavior in the three-chamber vicarious social defeat stress mouse model.
Topics: Animals; Anxiety; Behavior, Animal; Dependovirus; Depression; Disease Models, Animal; Dopaminergic N | 2022 |
Calorie restriction potentiates the therapeutic potential of GABA in managing type 2 diabetes in a mouse model.
Topics: Animals; Blood Glucose; Caloric Restriction; Diabetes Mellitus, Experimental; Diabetes Mellitus, Typ | 2022 |
Postweaning positive modulation of α5GABAA receptors improves autism-like features in prenatal valproate rat model in a sex-specific manner.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Calcium; Disease Models, Ani | 2022 |
Cell-Selective Adeno-Associated Virus-Mediated
Topics: Animals; Dependovirus; Disease Models, Animal; Epilepsies, Myoclonic; Epileptic Syndromes; gamma-Ami | 2022 |
Size anomaly and alteration of GABAergic enzymes expressions in cerebellum of a valproic acid mouse model of autism.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Cerebellum; Disease Models, Animal; Female; ga | 2022 |
Schistosomicidal and hepatoprotective activity of gamma-aminobutyric acid (GABA) alone or combined with praziquantel against Schistosoma mansoni infection in murine model.
Topics: Animals; Anthelmintics; Disease Models, Animal; gamma-Aminobutyric Acid; Liver; Mice; Praziquantel; | 2022 |
5-HT2A receptor dysregulation in a schizophrenia relevant mouse model of NMDA receptor hypofunction.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Mice; Pyramidal Cells; Receptor, Serotonin | 2022 |
Ketamine administration in early postnatal life as a tool for mimicking Autism Spectrum Disorders core symptoms.
Topics: Animals; Autism Spectrum Disorder; Brain-Derived Neurotrophic Factor; Disease Models, Animal; gamma- | 2022 |
Claudin-5 relieves cognitive decline in Alzheimer's disease mice through suppression of inhibitory GABAergic neurotransmission.
Topics: Alzheimer Disease; Animals; Claudin-5; Cognitive Dysfunction; Disease Models, Animal; gamma-Aminobut | 2022 |
Targeting α6GABA
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Humans; Methamphetamine; Mice; Phencyclidi | 2022 |
Generational synaptic functions of GABA
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Humans; | 2022 |
Effects of α5 GABA
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Female; gamma-Aminobutyri | 2022 |
Putrescine Intensifies Glu/GABA Exchange Mechanism and Promotes Early Termination of Seizures.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; gamma-Aminobutyric Acid; P | 2022 |
Validation of DREADD agonists and administration route in a murine model of sleep enhancement.
Topics: Animals; Designer Drugs; Disease Models, Animal; gamma-Aminobutyric Acid; Imidazoles; Mice; Sleep; S | 2022 |
GAD1 alleviates injury-induced optic neurodegeneration by inhibiting retinal ganglion cell apoptosis.
Topics: Animals; Apoptosis; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutam | 2022 |
Pronounced antiseizure activity of the subtype-selective GABA
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistant Epilepsy; Electroencephal | 2022 |
Pronounced antiseizure activity of the subtype-selective GABA
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistant Epilepsy; Electroencephal | 2022 |
Pronounced antiseizure activity of the subtype-selective GABA
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistant Epilepsy; Electroencephal | 2022 |
Pronounced antiseizure activity of the subtype-selective GABA
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistant Epilepsy; Electroencephal | 2022 |
The glutamate/GABA system in the retina of male rats: effects of aging, neurodegeneration, and supplementation with melatonin and antioxidant SkQ1.
Topics: Aging; Aminobutyrates; Animals; Antioxidants; Dietary Supplements; Disease Models, Animal; gamma-Ami | 2022 |
Minocycline Ameliorates Chronic Unpredictable Mild Stress-Induced Neuroinflammation and Abnormal mPFC-HIPP Oscillations in Mice.
Topics: Adenosine Triphosphate; Animals; Depression; Disease Models, Animal; gamma-Aminobutyric Acid; Glutam | 2022 |
Homotaurine ameliorates the core ASD symptomatology in VPA rats through GABAergic signaling: Role of GAD67.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Female; gamma-Aminobuty | 2022 |
Individual differences in the positive outcome from adolescent ketamine treatment in a female mouse model of anorexia nervosa involve drebrin A at excitatory synapses of the medial prefrontal cortex.
Topics: Animals; Anorexia; Anorexia Nervosa; Cytoplasm; Disease Models, Animal; Female; gamma-Aminobutyric A | 2023 |
Saffron essential oil ameliorates CUMS-induced depression-like behavior in mice via the MAPK-CREB1-BDNF signaling pathway.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Crocus; Depress | 2023 |
From bench to bedside: The mGluR5 system in people with and without Autism Spectrum Disorder and animal model systems.
Topics: Adult; Animals; Autism Spectrum Disorder; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic | 2022 |
Antidepressant effects of cherry leaf decoction on a chronic unpredictable mild stress rat model based on the Glu/GABA-Gln metabolic loop.
Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Corticosterone; Depression; Disease Mod | 2022 |
Comprehensive metabolomic characterization of the hippocampus in a ketamine mouse model of schizophrenia.
Topics: Amino Acids; Animals; Antipsychotic Agents; Biomarkers; Disease Models, Animal; gamma-Aminobutyric A | 2022 |
Altered basal forebrain function during whole-brain network activity at pre- and early-plaque stages of Alzheimer's disease in TgF344-AD rats.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Basal Forebrain; Cholinergic Agents; Disease Mode | 2022 |
Inhibition of GABA
Topics: Animals; beta Catenin; Bicuculline; Colitis; Colitis, Ulcerative; Colon; Cytokines; Dextran Sulfate; | 2022 |
Anxiety-like behavior and GABAergic system in ovariectomized rats exposed to chronic mild stress.
Topics: Animals; Anxiety; Behavior, Animal; Disease Models, Animal; Estrogens; Female; gamma-Aminobutyric Ac | 2023 |
Altered GABA
Topics: Animals; Disease Models, Animal; Epilepsy, Absence; gamma-Aminobutyric Acid; Mice; Receptors, GABA-A | 2022 |
Rice Germ Ameliorated Chronic Unpredictable Mild Stress-Induced Depressive-like Behavior by Reducing Neuroinflammation.
Topics: Animals; Antidepressive Agents; Caspases; Depression; Disease Models, Animal; gamma-Aminobutyric Aci | 2022 |
The effects of postnatal erythropoietin and nano-erythropoietin on behavioral alterations by mediating K-Cl co-transporter 2 in the valproic acid-induced rat model of autism.
Topics: Animals; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Erythropoietin; Female; gamma- | 2023 |
Early deficits in GABA inhibition parallels an increase in L-type Ca
Topics: Amyotrophic Lateral Sclerosis; Animals; Calcium Channels, L-Type; Disease Models, Animal; Drug Inver | 2023 |
Miniature-swine iPSC-derived GABA progenitor cells function in a rat Parkinson's disease model.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Dopaminergic Neurons; GABAergic Neurons; gamma-Ami | 2023 |
LINCs Are Vulnerable to Epileptic Insult and Fail to Provide Seizure Control via On-Demand Activation.
Topics: Animals; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; Female; gamma-Aminobutyric Acid; | 2023 |
Memantine/Aripiprazole Combination Alleviates Cognitive Dysfunction in Valproic Acid Rat Model of Autism: Hippocampal CREB/BDNF Signaling and Glutamate Homeostasis.
Topics: Animals; Aripiprazole; Autism Spectrum Disorder; Autistic Disorder; Brain-Derived Neurotrophic Facto | 2023 |
Early central cardiovagal dysfunction after high fat diet in a murine model.
Topics: Animals; Bradycardia; Diet, High-Fat; Disease Models, Animal; gamma-Aminobutyric Acid; Medulla Oblon | 2023 |
Effects of Escitalopram on the Functional Neural Circuits in an Animal Model of Adolescent Depression.
Topics: Animals; Citalopram; Depression; Disease Models, Animal; Escitalopram; gamma-Aminobutyric Acid; Glut | 2023 |
E2730, an uncompetitive γ-aminobutyric acid transporter-1 inhibitor, suppresses epileptic seizures in a rat model of chronic mesial temporal lobe epilepsy.
Topics: Adult; Animals; Disease Models, Animal; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; g | 2023 |
Hypothalamic GABRA5-positive neurons control obesity via astrocytic GABA.
Topics: Animals; Astrocytes; Disease Models, Animal; gamma-Aminobutyric Acid; Male; Mice; Monoamine Oxidase; | 2023 |
GABA
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Humans; | 2023 |
Modulation of GABA by sodium butyrate ameliorates hypothalamic inflammation in experimental model of PCOS.
Topics: Animals; Butyric Acid; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Humans; Letrozole; M | 2023 |
Burst and Tonic Spinal Cord Stimulation Both Activate Spinal GABAergic Mechanisms to Attenuate Pain in a Rat Model of Chronic Neuropathic Pain.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Ligation; Male; Neuralgia; Rats; Rats, Spr | 2020 |
Influence of intranasal exposure of MPTP in multiple doses on liver functions and transition from non-motor to motor symptoms in a rat PD model.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Administration, Intranasal; Alanine Transaminase; Anim | 2020 |
The NKCC1 antagonist bumetanide mitigates interneuronopathy associated with ethanol exposure in utero.
Topics: Alcohol Drinking; Animals; Bumetanide; Cerebral Cortex; Disease Models, Animal; Female; Fetal Alcoho | 2019 |
Electrical high frequency stimulation of the nucleus accumbens shell does not modulate depressive-like behavior in rats.
Topics: Animals; Behavior, Animal; Deep Brain Stimulation; Depression; Disease Models, Animal; gamma-Aminobu | 2020 |
Sodium Valproate Improves Skin Flap Survival via Gamma-Aminobutyric Acid and Histone Deacetylase Inhibitory System.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Graft Survival; Histone Deacetylases; Huma | 2020 |
Long-lasting correction of in vivo LTP and cognitive deficits of mice modelling Down syndrome with an α5-selective GABA
Topics: Animals; Cognition; Cognitive Dysfunction; Disease Models, Animal; Down Syndrome; GABA-A Receptor Ag | 2020 |
Rapid anti-PTSD-like activity of the TSPO agonist YL-IPA08: Emphasis on brain GABA, neurosteroids and HPA axis function.
Topics: Animals; Behavior, Animal; Carrier Proteins; Corticosterone; Disease Models, Animal; gamma-Aminobuty | 2020 |
Gamma-aminobutyric acid-producing lactobacilli positively affect metabolism and depressive-like behaviour in a mouse model of metabolic syndrome.
Topics: Adipose Tissue; Animals; Behavior, Animal; Body Weight; Cholesterol; Corticosterone; Depression; Dis | 2019 |
Ketamine rapidly reverses stress-induced impairments in GABAergic transmission in the prefrontal cortex in male rodents.
Topics: Animals; Antidepressive Agents; Depression; Disease Models, Animal; gamma-Aminobutyric Acid; Inhibit | 2020 |
NRG1-ErbB4 signaling promotes functional recovery in a murine model of traumatic brain injury via regulation of GABA release.
Topics: Animals; Behavior, Animal; Brain Injuries, Traumatic; Cell Death; Cells, Cultured; Disease Models, A | 2019 |
The mechanism of chronic nicotine exposure and nicotine withdrawal on pain perception in an animal model.
Topics: Animals; Baclofen; Bicuculline; Disease Models, Animal; Down-Regulation; Endorphins; gamma-Aminobuty | 2020 |
Vitamin D deficiency induces the excitation/inhibition brain imbalance and the proinflammatory shift.
Topics: Animals; Brain; Cholecalciferol; Cholesterol; Disease Models, Animal; gamma-Aminobutyric Acid; Gluta | 2020 |
Amantadine exerts anxiolytic like effect in mice: Evidences for the involvement of nitrergic and GABAergic signaling pathways.
Topics: Amantadine; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Brain; Diazepam; Disease Models | 2020 |
Change in serotonergic modulation contributes to the synaptic imbalance of neuronal circuit at the prefrontal cortex in the 15q11-13 duplication mouse model of autism.
Topics: Animals; Autism Spectrum Disorder; Cortical Excitability; Disease Models, Animal; DNA Copy Number Va | 2020 |
Aberrant Tonic Inhibition of Dopaminergic Neuronal Activity Causes Motor Symptoms in Animal Models of Parkinson's Disease.
Topics: Aged; Aged, 80 and over; Animals; Astrocytes; Disease Models, Animal; Dopaminergic Neurons; Down-Reg | 2020 |
Alpha-1 Adrenergic Receptors Modulate Glutamate and GABA Neurotransmission onto Ventral Tegmental Dopamine Neurons during Cocaine Sensitization.
Topics: Action Potentials; Animals; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopaminergic | 2020 |
Activating the interleukin-6-Gp130-STAT3 pathway ameliorates ventricular electrical stability in myocardial infarction rats by modulating neurotransmitters in the paraventricular nucleus.
Topics: Action Potentials; Animals; Cytokine Receptor gp130; Disease Models, Animal; gamma-Aminobutyric Acid | 2020 |
Anticonvulsant Activity of Essential Oil From Leaves of Zhumeria majdae (Rech.) in Mice: The Role of GABA
Topics: Animals; Anticonvulsants; Arginine; Diazepam; Disease Models, Animal; Dose-Response Relationship, Dr | 2020 |
Long-term vigabatrin treatment modifies pentylenetetrazole-induced seizures in mice: focused on GABA brain concentration.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Brain; Clonazepam; Disease Models, Animal; D | 2020 |
NaV1.1 and NaV1.6 selective compounds reduce the behavior phenotype and epileptiform activity in a novel zebrafish model for Dravet Syndrome.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsies, Myoclonic; gamma-Aminobutyric Acid; Hu | 2020 |
Hepatoprotective effects of gamma-aminobutyric acid-enriched fermented Hovenia dulcis extract on ethanol-induced liver injury in mice.
Topics: Animals; Chemical and Drug Induced Liver Injury; Chromatography; Disease Models, Animal; Ethanol; Fe | 2020 |
Alcohol dependence potentiates substance P/neurokinin-1 receptor signaling in the rat central nucleus of amygdala.
Topics: Adaptation, Physiological; Alcoholism; Animals; Central Amygdaloid Nucleus; Disease Models, Animal; | 2020 |
Acute Restraint Stress Evokes Anxiety-Like Behavior Mediated by Telencephalic Inactivation and GabAergic Dysfunction in Zebrafish Brains.
Topics: Animals; Behavior, Animal; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Receptors | 2020 |
Modeling Hippocampal CA1 Gabaergic Synapses of Audiogenic Rats.
Topics: Animals; CA1 Region, Hippocampal; Disease Models, Animal; Epilepsy, Reflex; gamma-Aminobutyric Acid; | 2020 |
Chronic hyperammonemia causes a hypoglutamatergic and hyperGABAergic metabolic state associated with neurobehavioral abnormalities in zebrafish larvae.
Topics: Animals; Behavior, Animal; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Hyperammo | 2020 |
Production of GABA-enriched idli with ACE inhibitory and antioxidant properties using Aspergillus oryzae: the antihypertensive effects in spontaneously hypertensive rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Aspergillus oryzae; Bloo | 2020 |
Inhibition of NADPH oxidase within midbrain periaqueductal gray decreases pain sensitivity in Parkinson's disease via GABAergic signaling pathway.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Male; Medial Forebrain Bundle; NADPH Oxida | 2020 |
Effect of γ-aminobutyric acid-rich yogurt on insulin sensitivity in a mouse model of type 2 diabetes mellitus.
Topics: Animals; Blood Glucose; Cholesterol, HDL; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2 | 2020 |
Downregulation of microRNA‑29c reduces pain after child delivery by activating the oxytocin‑GABA pathway.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Down-Regulation; Female; gamma-Aminobutyric Acid; | 2020 |
Blocking Astrocytic GABA Restores Synaptic Plasticity in Prefrontal Cortex of Rat Model of Depression.
Topics: Animals; Astrocytes; Atrophy; Depression; Disease Models, Animal; gamma-Aminobutyric Acid; Long-Term | 2020 |
Uncovering the contribution of enhanced central gain and altered cortical oscillations to tinnitus generation.
Topics: Animals; Auditory Cortex; Behavior, Animal; Brain Waves; Cyclooxygenase Inhibitors; Disease Models, | 2021 |
Exosomes derived from mesenchymal stem cells improved core symptoms of genetically modified mouse model of autism Shank3B.
Topics: Administration, Intranasal; Animals; Autistic Disorder; Behavior, Animal; Blood-Brain Barrier; Brain | 2020 |
CB1-Antibody Modified Liposomes for Targeted Modulation of Epileptiform Activities Synchronously Detected by Microelectrode Arrays.
Topics: Animals; Antibodies; Coordination Complexes; Disease Models, Animal; Epilepsy, Temporal Lobe; gamma- | 2020 |
Impairment of spatial memory accuracy improved by Cbr1 copy number resumption and GABA
Topics: Alcohol Oxidoreductases; Animals; Brain; Disease Models, Animal; DNA Copy Number Variations; Down Sy | 2020 |
Mechanisms underlying the enhancement of γ-aminobutyric acid responses in the external globus pallidus of R6/2 Huntington's disease model mice.
Topics: Animals; Disease Models, Animal; Electrophysiological Phenomena; Female; GABA Antagonists; GABA Plas | 2020 |
A Missense Variant in
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acid Sequence; Animals; Brain; Cerebrospinal Fluid; Deve | 2020 |
7,8-Dihydroxyflavone Alleviates Anxiety-Like Behavior Induced by Chronic Alcohol Exposure in Mice Involving Tropomyosin-Related Kinase B in the Amygdala.
Topics: Amygdala; Animals; Anxiety; Behavior, Animal; Carbazoles; Disease Models, Animal; Ethanol; Excitator | 2021 |
Effect of Withania somnifera (L.) Dunal aqueous root extract on reinstatement using conditioned place preference and brain GABA and dopamine levels in alcohol dependent animals.
Topics: Alcoholism; Animals; Behavior, Animal; Brain; Disease Models, Animal; Dopamine; Female; gamma-Aminob | 2021 |
GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model.
Topics: Animals; Astrocytes; Cell Membrane; Corpus Striatum; Disease Models, Animal; Dopamine; Down-Regulati | 2020 |
Elevated GABA levels in the medial prefrontal cortex and lower estrogen levels abolish cocaine sensitization behavior in ovariectomized female rats.
Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Upta | 2020 |
GABA in the medial prefrontal cortex regulates anxiety-like behavior during the postpartum period.
Topics: Animals; Anxiety; Behavior, Animal; Bicuculline; Disease Models, Animal; Female; GABA-A Receptor Ago | 2021 |
α6GABA
Topics: Animals; Disease Models, Animal; Fluorescent Antibody Technique; GABA Plasma Membrane Transport Prot | 2021 |
PHF24 is expressed in the inhibitory interneurons in rats.
Topics: Animals; Calbindin 2; Calbindins; Central Nervous System; Disease Models, Animal; gamma-Aminobutyric | 2021 |
Ultrastructural GABA immunogold labeling in the substantia nigra pars reticulata of kindled genetic absence epilepsy rats.
Topics: Animals; Disease Models, Animal; Epilepsy, Absence; gamma-Aminobutyric Acid; Immunohistochemistry; K | 2020 |
Effect of adzuki bean sprout fermented milk enriched in γ-aminobutyric acid on mild depression in a mouse model.
Topics: Animals; Cattle; Depression; Disease Models, Animal; Female; Fermentation; gamma-Aminobutyric Acid; | 2021 |
GABA-mediated activated microglia induce neuroinflammation in the hippocampus of mice following cold exposure through the NLRP3 inflammasome and NF-κB signaling pathways.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cold Temperature; Cold-Shock Response; Cytokines; Dise | 2020 |
Changes in neuronal excitability and synaptic transmission in nucleus accumbens in a transgenic Alzheimer's disease mouse model.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alzheimer Disease; Animals; Biomarkers; Di | 2020 |
Alterations of GABA B receptors in the APP/PS1 mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Memory; | 2021 |
Parabrachial nucleus circuit governs neuropathic pain-like behavior.
Topics: Animals; Disease Models, Animal; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; | 2020 |
Deficient astrocyte metabolism impairs glutamine synthesis and neurotransmitter homeostasis in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Astrocytes; Carbon Isotopes; Disease Mod | 2021 |
Depressive-like behaviors in mice with Imiquimod-induced psoriasis.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; | 2020 |
Sedative and hypnotic effects of Perilla frutescens essential oil through GABAergic system pathway.
Topics: Administration, Inhalation; Animals; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Gas Ch | 2021 |
Blockade of Retinal Oscillations by Benzodiazepines Improves Efficiency of Electrical Stimulation in the Mouse Model of RP, rd10.
Topics: Action Potentials; Animals; Benzodiazepines; Disease Models, Animal; Electric Stimulation Therapy; F | 2020 |
In vivo γ-aminobutyric acid increase as a biomarker of the epileptogenic zone: An unbiased metabolomics approach.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Electrophoresis, Capillary; Epileps | 2021 |
Combined the GABA-A and GABA-B receptor agonists attenuates autistic behaviors in a prenatal valproic acid-induced mouse model of autism.
Topics: Animals; Anticonvulsants; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Drug T | 2021 |
Decreased GABAergic signaling, fewer parvalbumin-, somatostatin- and calretinin-positive neurons in brain of a rat model of simulated transport stress.
Topics: Animals; Brain; Calbindin 2; Corticosterone; Disease Models, Animal; GABAergic Neurons; gamma-Aminob | 2021 |
Neurochemical Effects of 4-(2Chloro-4-Fluorobenzyl)-3-(2-Thienyl)-1,2,4-Oxadiazol-5(4H)-One in the Pentylenetetrazole (PTZ)-Induced Epileptic Seizure Zebrafish Model.
Topics: Animals; Anticonvulsants; Antioxidants; Brain; Brain Chemistry; Dihydrotestosterone; Disease Models, | 2021 |
Dysregulation of REV-ERBα impairs GABAergic function and promotes epileptic seizures in preclinical models.
Topics: Acute Disease; Animals; Basic-Leucine Zipper Transcription Factors; Chronic Disease; Disease Models, | 2021 |
Enzyme Replacement Therapy for Succinic Semialdehyde Dehydrogenase Deficiency: Relevance in γ-Aminobutyric Acid Plasticity.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Developmental Disabilities; Disease Models, Animal; E | 2021 |
A critical period of neuronal activity results in aberrant neurogenesis rewiring hippocampal circuitry in a mouse model of epilepsy.
Topics: Animals; Calcium; Clozapine; Disease Models, Animal; Electroencephalography; Epilepsy; Epilepsy, Tem | 2021 |
Environmental enrichment implies GAT-1 as a potential therapeutic target for stroke recovery.
Topics: Animals; Disease Models, Animal; Female; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric | 2021 |
Homotaurine limits the spreading of T cell autoreactivity within the CNS and ameliorates disease in a model of multiple sclerosis.
Topics: Animals; Antigen Presentation; Antigen-Presenting Cells; Cell Proliferation; Central Nervous System; | 2021 |
Antinociceptive effect of intrathecal P7C3 via GABA in a rat model of inflammatory pain.
Topics: Analgesics; Animals; Calcium Signaling; Carbazoles; Disease Models, Animal; Formaldehyde; gamma-Amin | 2021 |
Retinal Ganglion Cells Functional Changes in a Mouse Model of Alzheimer's Disease Are Linked with Neurotransmitter Alterations.
Topics: Age Factors; Alzheimer Disease; Animals; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Gl | 2021 |
Depolarizing GABA
Topics: Animals; Bumetanide; Cognitive Dysfunction; Disease Models, Animal; gamma-Aminobutyric Acid; Mice; P | 2021 |
Insulin as a potent bidirectional regulator of GABAergic signalling in the hippocampus of an Alzheimer's disease mouse model.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Hippocampus; Insulin; M | 2021 |
Orthopedic surgery-induced cognitive dysfunction is mediated by CX3CL1/R1 signaling.
Topics: Animals; Astrocytes; Chemokine CX3CL1; CX3C Chemokine Receptor 1; Disease Models, Animal; gamma-Amin | 2021 |
Susceptibility to chronic immobilization stress-induced depressive-like behaviour in middle-aged female mice and accompanying changes in dopamine D1 and GABA
Topics: Animals; Behavior, Animal; Brain; Depression; Disease Models, Animal; Dopamine; Female; gamma-Aminob | 2021 |
l-Theanine ameliorates motor deficit, mitochondrial dysfunction, and neurodegeneration against chronic tramadol induced rats model of Parkinson's disease.
Topics: Animals; Antioxidants; Corpus Striatum; Disease Models, Animal; Dopamine; gamma-Aminobutyric Acid; G | 2022 |
Metabolomic signature of the Dravet syndrome: A genetic mouse model study.
Topics: Animals; Bile Acids and Salts; Disease Models, Animal; Epilepsies, Myoclonic; Epileptic Syndromes; g | 2021 |
GABA- and Glycine-Mimetic Responses of Linalool on the Substantia Gelatinosa of the Trigeminal Subnucleus Caudalis in Juvenile Mice: Pain Management through Linalool-Mediated Inhibitory Neurotransmission.
Topics: Acyclic Monoterpenes; Animals; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Glycine; Mal | 2021 |
Early Functional Impairment in Experimental Glaucoma Is Accompanied by Disruption of the GABAergic System and Inceptive Neuroinflammation.
Topics: Animals; Cytoskeletal Proteins; Disease Models, Animal; Eye Proteins; Female; GABAergic Neurons; gam | 2021 |
Impact of Dysfunctional Feed-Forward Inhibition on Glutamate Decarboxylase Isoforms and γ-Aminobutyric Acid Transporters.
Topics: Animals; Disease Models, Animal; Epilepsy, Absence; Female; gamma-Aminobutyric Acid; Glutamate Decar | 2021 |
Anti-seizure effects of walnut peptides in mouse models of induced seizure: The involvement of GABA and nitric oxide pathways.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; gamma-Aminobutyr | 2021 |
Hippocampal and Reticulo-Thalamic Parvalbumin Interneurons and Synaptic Re-Organization during Sleep Disorders in the Rat Models of Parkinson's Disease Neuropathology.
Topics: Animals; Disease Models, Animal; Disks Large Homolog 4 Protein; gamma-Aminobutyric Acid; Hippocampus | 2021 |
[
Topics: Amines; Animals; Autoradiography; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-R | 2017 |
Attenuation of hyperalgesia responses via the modulation of 5-hydroxytryptamine signalings in the rostral ventromedial medulla and spinal cord in a 6-hydroxydopamine-induced rat model of Parkinson's disease.
Topics: 5,7-Dihydroxytryptamine; Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Hyperalgesia; Ind | 2017 |
Activations of muscarinic M
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Analgesics; Animals; Disease M | 2017 |
Levetiracetam synergizes with gabapentin, pregabalin, duloxetine and selected antioxidants in a mouse diabetic painful neuropathy model.
Topics: Amines; Analgesics; Animals; Anticonvulsants; Antioxidants; Cyclohexanecarboxylic Acids; Diabetes Me | 2017 |
In vivo evaluation of the hippocampal glutamate, GABA and the BDNF levels associated with spatial memory performance in a rodent model of neuropathic pain.
Topics: Analysis of Variance; Animals; Brain-Derived Neurotrophic Factor; Chromatography, High Pressure Liqu | 2017 |
Reduced Lateral Inhibition Impairs Olfactory Computations and Behaviors in a Drosophila Model of Fragile X Syndrome.
Topics: Animals; Animals, Genetically Modified; Behavior, Animal; Cell Differentiation; Disease Models, Anim | 2017 |
Characterization of the Effects of L-4-Chlorokynurenine on Nociception in Rodents.
Topics: Amines; Analgesics; Animals; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dizocilpine | 2017 |
Improvement of Antioxidant Defences and Mood Status by Oral GABA Tea Administration in a Mouse Model of Post-Stroke Depression.
Topics: Affect; Animals; Depression; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamates; Glutamic A | 2017 |
Murine model and mechanisms of treatment-induced painful diabetic neuropathy.
Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Diabetic Neuropathies; Disease Models, Animal; Enzyme | 2017 |
Risk to heroin users of polydrug use of pregabalin or gabapentin.
Topics: Adult; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Drug Intera | 2017 |
Alpha7 nicotinic acetylcholine receptor agonist promotes retinal ganglion cell function via modulating GABAergic presynaptic activity in a chronic glaucomatous model.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzamides; Bridged Bicyclo Compounds; Cell Surviv | 2017 |
Type 2 diabetes alters hippocampal gamma oscillations: A potential mechanism behind impaired cognition.
Topics: Animals; Cognition; Cognitive Dysfunction; Diabetes Mellitus, Type 2; Disease Models, Animal; Gamma | 2017 |
Anticonvulsant profile of the neuroactive steroid, SGE-516, in animal models.
Topics: Action Potentials; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Electroshock; Frag | 2017 |
JIEYUANSHEN DECOCTION EXERTS ANTIDEPRESSANT EFFECTS ON DEPRESSIVE RAT MODEL VIA REGULATING HPA AXIS AND THE LEVEL OF AMINO ACIDS NEUROTRANSMITTER.
Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Chronic Disease; Corticosterone; Cortic | 2017 |
Abnormal γ-aminobutyric acid neurotransmission in a Kcnq2 model of early onset epilepsy.
Topics: Animals; Animals, Newborn; Biophysics; CA1 Region, Hippocampal; Disease Models, Animal; Electric Sti | 2017 |
Protective effect of gallic acid in experimental model of ketamine-induced psychosis: possible behaviour, biochemical, neurochemical and cellular alterations.
Topics: Animals; Antioxidants; Behavior, Animal; Brain; Disease Models, Animal; Female; Gallic Acid; gamma-A | 2018 |
Effect of Gabapentin/Memantine on the Infantile Nystagmus Syndrome in the Zebrafish Model: Implications for the Therapy of Ocular Motor Diseases.
Topics: Amines; Animals; Calcium Channel Blockers; Cyclohexanecarboxylic Acids; Disease Models, Animal; Exci | 2017 |
Reduced protein expressions of cytomembrane GABA
Topics: Animals; Autism Spectrum Disorder; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; | 2017 |
Sigma 2 Receptor/Tmem97 Agonists Produce Long Lasting Antineuropathic Pain Effects in Mice.
Topics: Amines; Analgesics, Opioid; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin | 2017 |
Maerua angolensis stem bark extract reverses anxiety and related behaviours in zebrafish-Involvement of GABAergic and 5-HT systems.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Capparaceae; Desipramine; Diazepam; Disease | 2017 |
Depolarized GABAergic Signaling in Subicular Microcircuits Mediates Generalized Seizure in Temporal Lobe Epilepsy.
Topics: Adolescent; Adult; Animals; Case-Control Studies; Disease Models, Animal; Electroencephalography; Ep | 2017 |
Intervertebral Foramen Injection of Ozone Relieves Mechanical Allodynia and Enhances Analgesic Effect of Gabapentin in Animal Model of Neuropathic Pain.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Follow-Up Studies; | 2017 |
Effects of ERK1/2 kinases inactivation on the nigrostriatal system of Krushinsky-Molodkina rats genetically prone to audiogenic seizures.
Topics: Acoustic Stimulation; Aminoacetonitrile; Animals; Auditory Perception; Corpus Striatum; Disease Mode | 2017 |
Investigation of spinal nerve ligation-mediated functional activation of the rat brain using manganese-enhanced MRI.
Topics: Amines; Animals; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; gamma-Amino | 2018 |
Activity-Dependent Brain-Derived Neurotrophic Factor Release Is Required for the Rapid Antidepressant Actions of Scopolamine.
Topics: Animals; Antidepressive Agents; Brain; Brain-Derived Neurotrophic Factor; Calcium Channels, L-Type; | 2018 |
Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer's disease: analysis of Osaka mutation-knockin mice.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Diazepam; Disease Models, Animal; | 2017 |
Effect of teriflunomide on cortex-basal ganglia-thalamus (CxBGTh) circuit glutamatergic dysregulation in the Theiler's Murine Encephalomyelitis Virus mouse model of multiple sclerosis.
Topics: Animals; Basal Ganglia; Cell Line; Corpus Callosum; Crotonates; Disease Models, Animal; Drug Evaluat | 2017 |
Gabapentin prevents cortical spreading depolarization-induced disinhibition.
Topics: Action Potentials; Amines; Animals; Cortical Spreading Depression; Cyclohexanecarboxylic Acids; Dise | 2017 |
Increase in cortical endocannabinoid signaling in a rat model of basal forebrain cholinergic dysfunction.
Topics: Animals; Antibodies, Monoclonal; Basal Forebrain; Cerebral Cortex; Cholinergic Neurons; Disease Mode | 2017 |
Multiple sites and actions of gabapentin-induced relief of ongoing experimental neuropathic pain.
Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; gamma-Aminobutyric | 2017 |
Persistent seizure control in epileptic mice transplanted with gamma-aminobutyric acid progenitors.
Topics: Animals; Cell Differentiation; Convulsants; Disease Models, Animal; Embryo, Mammalian; Epilepsy; Exp | 2017 |
Quality components and antidepressant-like effects of GABA green tea.
Topics: Animals; Antidepressive Agents; Camellia sinensis; Depression; Disease Models, Animal; Female; gamma | 2017 |
Periaqueductal Gray Glutamatergic Transmission Governs Chronic Stress-Induced Depression.
Topics: Anhedonia; Animals; Behavior, Animal; Depression; Disease Models, Animal; gamma-Aminobutyric Acid; G | 2018 |
Effects of S 38093, an antagonist/inverse agonist of histamine H3 receptors, in models of neuropathic pain in rats.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; gamma- | 2018 |
Gabapentin regulates expression of FGF2 and FGFR1 in dorsal root ganglia via microRNA-15a in the arthritis rat model.
Topics: Amines; Animals; Arthritis, Experimental; Cyclohexanecarboxylic Acids; Disease Models, Animal; Fibro | 2017 |
Laser Acupuncture at HT7 Improves the Cerebellar Disorders in Valproic Acid-Rat Model of Autism.
Topics: Acupuncture Points; Acupuncture Therapy; Animals; Autistic Disorder; Cerebellar Diseases; Cerebellum | 2017 |
Retinal Astrocytes and GABAergic Wide-Field Amacrine Cells Express PDGFRα: Connection to Retinal Ganglion Cell Neuroprotection by PDGF-AA.
Topics: Amacrine Cells; Animals; Astrocytes; Biotin; Blotting, Western; Cell Survival; Cells, Cultured; Chol | 2017 |
Altered serotonergic and GABAergic neurotransmission in a mice model of obsessive-compulsive disorder.
Topics: Analysis of Variance; Animals; Animals, Newborn; Brain; Disease Models, Animal; Dopamine; gamma-Amin | 2018 |
The neurobiological bases of autism spectrum disorders: the R451C-neuroligin 3 mutation hampers the expression of long-term synaptic depression in the dorsal striatum.
Topics: Animals; Autism Spectrum Disorder; Cell Adhesion Molecules, Neuronal; Disease Models, Animal; Electr | 2018 |
Magnesium Sulfate Prevents Neurochemical and Long-Term Behavioral Consequences of Neonatal Excitotoxic Lesions: Comparison Between Male and Female Mice.
Topics: Aging; Animals; Animals, Newborn; Brain; Calcium Channel Blockers; Disease Models, Animal; Excitator | 2017 |
Defective GABAergic neurotransmission in the nucleus tractus solitarius in Mecp2-null mice, a model of Rett syndrome.
Topics: Animals; Disease Models, Animal; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Inhibitory Posts | 2018 |
Testing the excitation/inhibition imbalance hypothesis in a mouse model of the autism spectrum disorder: in vivo neurospectroscopy and molecular evidence for regional phenotypes.
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; DNA-Binding Proteins; Female; gamma-Amino | 2017 |
SSa ameliorates the Glu uptaking capacity of astrocytes in epilepsy via AP-1/miR-155/GLAST.
Topics: Animals; Astrocytes; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Transporter 1; gamma-Am | 2017 |
The flavonoid 6-methoxyflavone allays cisplatin-induced neuropathic allodynia and hypoalgesia.
Topics: Amines; Analgesics; Animals; Antineoplastic Agents; Behavior, Animal; Cisplatin; Cyclohexanecarboxyl | 2017 |
The monoacylglycerol lipase inhibitor KML29 with gabapentin synergistically produces analgesia in mice.
Topics: Amines; Analgesics; Animals; Benzodioxoles; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dos | 2017 |
Early neonatal loss of inhibitory synaptic input to the spinal motor neurons confers spina bifida-like leg dysfunction in a chicken model.
Topics: Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Caspase 3; Chick Embryo; Chickens; Choline; | 2017 |
Recombinant tissue plasminogen activator induces long-term anxiety-like behaviors via the ERK1/2-GAD1-GABA cascade in the hippocampus of a rat model.
Topics: Animals; Anxiety; bcl-2-Associated X Protein; Body Weight; Disease Models, Animal; Exploratory Behav | 2018 |
Disease-modifying effects of ganglioside GM1 in Huntington's disease models.
Topics: Animals; Behavior, Animal; Body Weight; Brain; Calcium-Binding Proteins; Disease Models, Animal; Dop | 2017 |
Protective roles of hepatic gamma-aminobutyric acid signaling in acute ethanol exposure-induced liver injury.
Topics: Acute Disease; Adult; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Disease Models, An | 2018 |
Pyridoxine-Dependent Epilepsy in Zebrafish Caused by Aldh7a1 Deficiency.
Topics: Aldehyde Dehydrogenase; Animals; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Gene Kno | 2017 |
Emergence of early alterations in network oscillations and functional connectivity in a tau seeding mouse model of Alzheimer's disease pathology.
Topics: Alzheimer Disease; Animals; Cognition; Disease Models, Animal; Electroencephalography; gamma-Aminobu | 2017 |
Atomic force microscopy investigations of fibronectin and α5β1-integrin signaling in neuroplasticity and seizure susceptibility in experimental epilepsy.
Topics: 4-Aminopyridine; Action Potentials; Animals; Disease Models, Animal; Epilepsy; Excitatory Amino Acid | 2017 |
Modification of the natural progression of epileptogenesis by means of biperiden in the pilocarpine model of epilepsy.
Topics: Action Potentials; Animals; Autonomic Nervous System; Biperiden; Chronic Disease; Cytokines; Disease | 2017 |
A bell-shaped dependence between amyloidosis and GABA accumulation in astrocytes in a mouse model of Alzheimer's disease.
Topics: Aging; Alzheimer Disease; Amyloidogenic Proteins; Amyloidosis; Animals; Astrocytes; Brain; Disease M | 2018 |
Developmental excitatory-to-inhibitory GABA-polarity switch is disrupted in 22q11.2 deletion syndrome: a potential target for clinical therapeutics.
Topics: Animals; Bumetanide; DiGeorge Syndrome; Disease Models, Animal; gamma-Aminobutyric Acid; Hippocampus | 2017 |
Sex- and age-specific modulation of brain GABA levels in a mouse model of Alzheimer's disease.
Topics: Aging; Alzheimer Disease; Amyloidogenic Proteins; Animals; Astrocytes; Brain; Disease Models, Animal | 2018 |
Behavior Disorders Caused by Perinatal Hypoxia in Juvenile Rats and Their Correction with GABA Derivative.
Topics: Animals; Animals, Newborn; Behavior, Animal; Disease Models, Animal; Female; Forelimb; gamma-Aminobu | 2017 |
Marble burying as compulsive behaviors in male and female mice.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Behavior, Animal; Citalopram; Compulsive Behavio | 2017 |
PACAP-(6-38) or kynurenate microinjections in the RVLM prevent the development of sympathetic long-term facilitation after acute intermittent hypoxia.
Topics: Acute Disease; Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Hypertension | 2018 |
Synaptic adaptations to chronic ethanol intake in male rhesus monkey dorsal striatum depend on age of drinking onset.
Topics: Adaptation, Physiological; Age Factors; Age of Onset; Alcohol Drinking; Animals; Central Nervous Sys | 2018 |
Anxiety, neuroinflammation, cholinergic and GABAergic abnormalities are early markers of Gulf War illness in a mouse model of the disease.
Topics: Acetylcholine; Animals; Anxiety; Astrocytes; Brain; DEET; Disease Models, Animal; Encephalitis; Fema | 2018 |
The Role of Succinate in Regulation of Immediate HIF-1α Expression in Hypoxia.
Topics: Adaptation, Physiological; Altitude Sickness; Animals; Cerebral Cortex; Citric Acid Cycle; Disease M | 2018 |
Comprehensive characterization of neurochemicals in three zebrafish chemical models of human acute organophosphorus poisoning using liquid chromatography-tandem mass spectrometry.
Topics: Acetylcholine; Animals; Chromatography, High Pressure Liquid; Disease Models, Animal; Dopamine; Epin | 2018 |
Restoring GABAergic inhibition rescues memory deficits in a Huntington's disease mouse model.
Topics: Animals; Bumetanide; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Hippocampus; Humans; H | 2018 |
Neuromuscular features of hypophosphatasia.
Topics: Adult; Alkaline Phosphatase; Animals; Biomarkers; Brain Diseases; Chronic Pain; Disease Models, Anim | 2017 |
Effects of ralfinamide in models of nerve injury and chemotherapy-induced neuropathic pain.
Topics: Amines; Analgesics; Animals; Antineoplastic Agents; Blood Pressure; Cyclohexanecarboxylic Acids; Dis | 2018 |
Dendritic Cell Factor 1-Knockout Results in Visual Deficit Through the GABA System in Mouse Primary Visual Cortex.
Topics: Animals; Brain Waves; Disease Models, Animal; Electroencephalography; gamma-Aminobutyric Acid; Gene | 2018 |
Efficacy and safety of combined low doses of either diclofenac or celecoxib with gabapentin versus their single high dose in treatment of neuropathic pain in rats.
Topics: Amines; Analgesics; Animals; Behavior, Animal; Celecoxib; Cyclohexanecarboxylic Acids; Diclofenac; D | 2018 |
Stabilized Low-n Amyloid-β Oligomers Induce Robust Novel Object Recognition Deficits Associated with Inflammatory, Synaptic, and GABAergic Dysfunction in the Rat.
Topics: Amyloid beta-Peptides; Animals; Brain; Cognition; Disease Models, Animal; Donepezil; Female; gamma-A | 2018 |
Study on antidepressant activity of chiisanoside in mice.
Topics: Animals; Anti-Inflammatory Agents; Antidepressive Agents; Brain; Brain-Derived Neurotrophic Factor; | 2018 |
Developmental changes of GABA immunoreactivity in cortico-thalamic networks of an absence seizure model.
Topics: Animals; Cerebral Cortex; Disease Models, Animal; Epilepsy, Absence; GABAergic Neurons; gamma-Aminob | 2018 |
Evaluation of the neonatal streptozotocin model of diabetes in rats: Evidence for a model of neuropathic pain.
Topics: Activating Transcription Factor 3; Amines; Animals; Animals, Newborn; Astrocytes; Cyclohexanecarboxy | 2018 |
Behavioral effects of toll-like receptor-4 antagonist 'eritoran' in an experimental model of depression: role of prefrontal and hippocampal neurogenesis and γ-aminobutyric acid/glutamate balance.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Depression; Depressive Disorder; | 2018 |
Pulmonary neuroendocrine cells amplify allergic asthma responses.
Topics: Animals; Asthma; Basic Helix-Loop-Helix Transcription Factors; Calcitonin Gene-Related Peptide; Cyto | 2018 |
Taurine Administration Recovers Motor and Learning Deficits in an Angelman Syndrome Mouse Model.
Topics: Angelman Syndrome; Animals; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Learning; Male; | 2018 |
Effects of cariprazine on extracellular levels of glutamate, GABA, dopamine, noradrenaline and serotonin in the medial prefrontal cortex in the rat phencyclidine model of schizophrenia studied by microdialysis and simultaneous recordings of locomotor acti
Topics: Animals; Antipsychotic Agents; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; E | 2018 |
A whole brain longitudinal study in the YAC128 mouse model of Huntington's disease shows distinct trajectories of neurochemical, structural connectivity and volumetric changes.
Topics: Animals; Brain; Corpus Striatum; Disease Models, Animal; gamma-Aminobutyric Acid; Gene Expression Re | 2018 |
Protective effects of stigmasterol against ketamine-induced psychotic symptoms: Possible behavioral, biochemical and histopathological changes in mice.
Topics: Acetylcholine; Animals; Antipsychotic Agents; Brain; Catalepsy; Disease Models, Animal; Dopamine; ga | 2018 |
Inter-individual differences in serotonin and glutamate co-transmission reflect differentiation in context-induced conditioned 50-kHz USVs response after morphine withdrawal.
Topics: Animals; Behavior, Animal; Brain; Conditioning, Psychological; Disease Models, Animal; gamma-Aminobu | 2018 |
Altered brain activity during withdrawal from chronic alcohol is associated with changes in IL-6 signal transduction and GABAergic mechanisms in transgenic mice with increased astrocyte expression of IL-6.
Topics: Alcoholism; Animals; Astrocytes; Brain; Central Nervous System Depressants; Disease Models, Animal; | 2018 |
Glutamate and GABA in autism spectrum disorder-a translational magnetic resonance spectroscopy study in man and rodent models.
Topics: Adult; Animals; Autism Spectrum Disorder; Brain; Corpus Striatum; Disease Models, Animal; Female; ga | 2018 |
The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet.
Topics: Animals; Anti-Bacterial Agents; Bacteroides; Diet, Ketogenic; Disease Models, Animal; Feces; gamma-A | 2018 |
The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet.
Topics: Animals; Anti-Bacterial Agents; Bacteroides; Diet, Ketogenic; Disease Models, Animal; Feces; gamma-A | 2018 |
The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet.
Topics: Animals; Anti-Bacterial Agents; Bacteroides; Diet, Ketogenic; Disease Models, Animal; Feces; gamma-A | 2018 |
The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet.
Topics: Animals; Anti-Bacterial Agents; Bacteroides; Diet, Ketogenic; Disease Models, Animal; Feces; gamma-A | 2018 |
The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet.
Topics: Animals; Anti-Bacterial Agents; Bacteroides; Diet, Ketogenic; Disease Models, Animal; Feces; gamma-A | 2018 |
The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet.
Topics: Animals; Anti-Bacterial Agents; Bacteroides; Diet, Ketogenic; Disease Models, Animal; Feces; gamma-A | 2018 |
The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet.
Topics: Animals; Anti-Bacterial Agents; Bacteroides; Diet, Ketogenic; Disease Models, Animal; Feces; gamma-A | 2018 |
The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet.
Topics: Animals; Anti-Bacterial Agents; Bacteroides; Diet, Ketogenic; Disease Models, Animal; Feces; gamma-A | 2018 |
The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet.
Topics: Animals; Anti-Bacterial Agents; Bacteroides; Diet, Ketogenic; Disease Models, Animal; Feces; gamma-A | 2018 |
GABAergic deficits and schizophrenia-like behaviors in a mouse model carrying patient-derived neuroligin-2 R215H mutation.
Topics: Animals; Behavior, Animal; Cell Adhesion Molecules, Neuronal; Disease Models, Animal; gamma-Aminobut | 2018 |
Anticonvulsive effects of protodioscin against pilocarpine-induced epilepsy.
Topics: Animals; Anticonvulsants; Apoptosis; bcl-2-Associated X Protein; Behavior, Animal; Biomarkers; Caspa | 2018 |
Effects of chronic noise exposure on the microbiome-gut-brain axis in senescence-accelerated prone mice: implications for Alzheimer's disease.
Topics: Aging; Animals; Avoidance Learning; Brain; Claudins; Cognition Disorders; Corticosterone; Cytokines; | 2018 |
A MicroRNA-Based Gene-Targeting Tool for Virally Labeling Interneurons in the Rodent Cortex.
Topics: Animals; Autistic Disorder; Cerebral Cortex; Dependovirus; Disease Models, Animal; gamma-Aminobutyri | 2018 |
Intracerebroventricular streptozotocin-induced Alzheimer's disease-like sleep disorders in rats: Role of the GABAergic system in the parabrachial complex.
Topics: Alzheimer Disease; Analysis of Variance; Animals; Antibiotics, Antineoplastic; Arousal; Disease Mode | 2018 |
Influence of hippocampal low-frequency stimulation on GABA
Topics: Amygdala; Animals; Brain-Derived Neurotrophic Factor; Cyclic AMP Response Element Modulator; Disease | 2018 |
Research Reveals Mechanism That May Drive Alcohol Use Disorder.
Topics: Alcoholism; Amygdala; Animals; Behavior, Addictive; Disease Models, Animal; Down-Regulation; Ethanol | 2018 |
Anticonvulsant effects after grafting of rat, porcine, and human mesencephalic neural progenitor cells into the rat subthalamic nucleus.
Topics: Animals; Convulsants; Disease Models, Animal; Embryo, Mammalian; Epilepsy; Fetus; gamma-Aminobutyric | 2018 |
Identification of a molecular locus for normalizing dysregulated GABA release from interneurons in the Fragile X brain.
Topics: Animals; Disease Models, Animal; Fragile X Mental Retardation Protein; Fragile X Syndrome; gamma-Ami | 2020 |
Acute inflammation sensitizes knee-innervating sensory neurons and decreases mouse digging behavior in a TRPV1-dependent manner.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Capsaicin; Cells, Cultured; Disease Mo | 2018 |
GABAρ3 expression in lobule X of the cerebellum is reduced in the valproate model of autism.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Cerebellum; Disease Models, Animal; Female; gam | 2018 |
Gut Microbes May Account for the Anti-Seizure Effects of the Ketogenic Diet.
Topics: Animals; Bacteroidetes; Diet, Ketogenic; Disease Models, Animal; gamma-Aminobutyric Acid; Gastrointe | 2018 |
phMRI, neurochemical and behavioral responses to psychostimulants distinguishing genetically selected alcohol-preferring from genetically heterogenous rats.
Topics: Alcoholism; Amphetamine; Amygdala; Animals; Brain; Central Nervous System Stimulants; Cocaine; Condi | 2019 |
A proteomics-metabolomics approach indicates changes in hypothalamic glutamate-GABA metabolism of adult female rats submitted to intrauterine growth restriction.
Topics: Animals; Disease Models, Animal; Female; Fetal Growth Retardation; gamma-Aminobutyric Acid; Glutamic | 2019 |
Design, synthesis, and molecular docking study of benzothiazolotriazine derivatives for anticonvulsant potential.
Topics: Animals; Anticonvulsants; Benzothiazoles; Binding Sites; Disease Models, Animal; Dose-Response Relat | 2018 |
Tropomyosin Receptor Kinase B Receptor Activation in the Locus Coeruleus Restores Impairment of Endogenous Analgesia at a Late Stage Following Nerve Injury in Rats.
Topics: Analgesics; Animals; Disease Models, Animal; Flavones; gamma-Aminobutyric Acid; Glutamic Acid; Hyper | 2019 |
Synaptic adaptations in the central amygdala and hypothalamic paraventricular nucleus associated with protracted ethanol abstinence in male rhesus monkeys.
Topics: Adaptation, Physiological; Alcohol Abstinence; Alcoholism; Animals; Central Amygdaloid Nucleus; Cent | 2019 |
Pulmonary Neuroendocrine Cells Secrete γ-Aminobutyric Acid to Induce Goblet Cell Hyperplasia in Primate Models.
Topics: Acute Lung Injury; Animals; Asthma; Bronchi; Disease Models, Animal; Epithelial Cells; gamma-Aminobu | 2019 |
Analysis of the protective effects of γ-aminobutyric acid during fluoride-induced hypothyroidism in male Kunming mice.
Topics: Animals; Antioxidants; Disease Models, Animal; Dose-Response Relationship, Drug; gamma-Aminobutyric | 2019 |
GABA, γ-Aminobutyric Acid, Protects Against Severe Liver Injury.
Topics: Aminosalicylic Acids; Animals; Benzenesulfonates; Disease Models, Animal; Galactosamine; gamma-Amino | 2019 |
[Altered Expression of Neurotransmitters Systems' Genes in the Ventral Tegmental Area of Depressive Male Mice: Data of RNA-Seq].
Topics: Animals; Anxiety; Depression; Disease Models, Animal; Dominance-Subordination; Dopamine; gamma-Amino | 2017 |
Minocycline ameliorates anxiety-related self-grooming behaviors and alters hippocampal neuroinflammation, GABA and serum cholesterol levels in female Sprague-Dawley rats subjected to chronic unpredictable mild stress.
Topics: Animals; Anxiety; Anxiety Disorders; Behavior, Animal; Cholesterol; Depression; Depressive Disorder; | 2019 |
Enhanced striatopallidal gamma-aminobutyric acid (GABA)
Topics: Animals; Corpus Striatum; Disease Models, Animal; Electric Stimulation; Electrophysiological Phenome | 2019 |
GABA-containing compound gammapyrone protects against brain impairments in Alzheimer's disease model male rats and prevents mitochondrial dysfunction in cell culture.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Astrocytes; Brain; Cells, Cultured; Disease Models | 2019 |
Transplanting GABAergic Neurons Differentiated from Neural Stem Cells into Hippocampus Inhibits Seizures and Epileptiform Discharges in Pilocarpine-Induced Temporal Lobe Epilepsy Model.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Drug Resistant Epilepsy; Electroencephalography; | 2019 |
Precisely controlling endogenous protein dosage in hPSCs and derivatives to model FOXG1 syndrome.
Topics: Animals; Cell Differentiation; Disease Models, Animal; Forkhead Transcription Factors; gamma-Aminobu | 2019 |
GABRP regulates chemokine signalling, macrophage recruitment and tumour progression in pancreatic cancer through tuning KCNN4-mediated Ca
Topics: Adenocarcinoma; Animals; Chemokines; Disease Models, Animal; gamma-Aminobutyric Acid; Humans; Interm | 2019 |
Molecular mechanism of tuberoinfundibular peptide of 39 on glucocorticoid receptor mediated glutamate/GABA imbalance and cerebral abnormalities against cognitive deficit model.
Topics: Animals; Cognitive Dysfunction; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; | 2019 |
Enhanced Na
Topics: Animals; Caudate Nucleus; Disease Models, Animal; gamma-Aminobutyric Acid; Humans; Huntington Diseas | 2019 |
Delayed maturation of GABAergic signaling in the Scn1a and Scn1b mouse models of Dravet Syndrome.
Topics: Animals; Bumetanide; Death, Sudden; Disease Models, Animal; Epilepsies, Myoclonic; Epilepsy; gamma-A | 2019 |
The Anticonvulsant Effects of Baldrinal on Pilocarpine-Induced convulsion in Adult Male Mice.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Glutamic | 2019 |
Acetylcholine receptor agonist effect on seizure activity and GABAergic mechanisms involved in prolonged febrile seizure development in an animal model.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Cholinergic Agonists; Disease Models, Animal; Fema | 2019 |
Role of microRNA-155 in modifying neuroinflammation and γ-aminobutyric acid transporters in specific central regions after post-ischaemic seizures.
Topics: Amygdala; Animals; Brain Ischemia; Disease Models, Animal; Epilepsy; GABA Plasma Membrane Transport | 2019 |
Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice.
Topics: 4-Aminopyridine; Animals; Brain; Craniotomy; Disease Models, Animal; Electrophoresis; Epilepsy; gamm | 2019 |
The maternal immune activation model uncovers a role for the Arx gene in GABAergic dysfunction in schizophrenia.
Topics: Adult; Animals; Brain; Disease Models, Animal; Female; GABA Agents; Gamma Rhythm; gamma-Aminobutyric | 2019 |
Activation of arcuate nucleus GABA neurons promotes luteinizing hormone secretion and reproductive dysfunction: Implications for polycystic ovary syndrome.
Topics: Androgens; Animals; Arcuate Nucleus of Hypothalamus; Brain; Disease Models, Animal; Female; GABAergi | 2019 |
Persistent
Topics: Animals; Brain; Chemokine CX3CL1; Chronic Disease; Complement Activation; Disease Models, Animal; Fe | 2019 |
Effect of cannabidiol on endocannabinoid, glutamatergic and GABAergic signalling markers in male offspring of a maternal immune activation (poly I:C) model relevant to schizophrenia.
Topics: Animals; Cannabidiol; Disease Models, Animal; Endocannabinoids; Female; gamma-Aminobutyric Acid; Glu | 2019 |
Obesity-induced type 2 diabetes impairs neurological recovery after stroke in correlation with decreased neurogenesis and persistent atrophy of parvalbumin-positive interneurons.
Topics: Age Factors; Animals; Atrophy; Brain; Diabetes Mellitus, Type 2; Disease Models, Animal; gamma-Amino | 2019 |
Role of nitric oxide synthase on brain GABA transaminase activity and GABA levels.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Brain; Disease Models, Animal; gamma-Aminobu | 2018 |
Peripheral nerve injury in rats induces alternations in choice behavior associated with food reinforcement.
Topics: Animals; Choice Behavior; Disease Models, Animal; Food; gamma-Aminobutyric Acid; Hyperalgesia; Ligat | 2019 |
Cuprizone-treated mice, a possible model of schizophrenia, highlighting the simultaneous abnormalities of GABA, serine and glycine in hippocampus.
Topics: Animals; Cuprizone; Disease Models, Animal; gamma-Aminobutyric Acid; Glycine; Hippocampus; Male; Met | 2019 |
The effect of exercise on GABA signaling pathway in the model of chemically induced seizures.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Gene Expression; Glutamate Decarboxylase; | 2019 |
Temporal effect of acupuncture on amino acid neurotransmitters in rats with acute cerebral ischaemia.
Topics: Acupuncture Therapy; Animals; Brain Ischemia; Disease Models, Animal; gamma-Aminobutyric Acid; Gluta | 2019 |
Enhanced Glutamatergic Currents at Birth in Shank3 KO Mice.
Topics: Animals; Animals, Newborn; Autism Spectrum Disorder; CA3 Region, Hippocampal; Disease Models, Animal | 2019 |
Dual dose-dependent effects of fingolimod in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Brain; Disease Models, Animal; Drug R | 2019 |
Intervention changes acoustic peak frequency and mesolimbic neurochemistry in the Pink1-/- rat model of Parkinson disease.
Topics: Animals; Animals, Genetically Modified; Catecholamines; Disease Models, Animal; gamma-Aminobutyric A | 2019 |
A perturbation of multimodal GABA functions underlying the formation of focal cortical malformations: assessments by using animal models.
Topics: Animals; Cerebral Cortex; Disease Models, Animal; gamma-Aminobutyric Acid; Malformations of Cortical | 2013 |
The antinociceptive effect of reversible monoamine oxidase-A inhibitors in a mouse neuropathic pain model.
Topics: Analgesics; Analysis of Variance; Animals; Anisoles; Disease Models, Animal; Dose-Response Relations | 2013 |
Effects of pregabalin on behavioral alterations induced by ketamine in rats.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, | 2012 |
Vigabatrin inhibits seizures and mTOR pathway activation in a mouse model of tuberous sclerosis complex.
Topics: Animals; Anticonvulsants; Astrocytes; Brain; Cell Proliferation; Cells, Cultured; Disease Models, An | 2013 |
Exposure to the cytokine EGF leads to abnormal hyperactivity of pallidal GABA neurons: implications for schizophrenia and its modeling.
Topics: Action Potentials; Animals; Animals, Newborn; Antipsychotic Agents; Disease Models, Animal; Electroe | 2013 |
Oral gabapentin suppresses pentylenetetrazole-induced seizure-like behavior and cephalic field potential in adult zebrafish.
Topics: Action Potentials; Administration, Oral; Amines; Analysis of Variance; Animals; Anticonvulsants; Bra | 2013 |
Hippocampal volume and cell density changes in a mouse model of human genetic epilepsy.
Topics: Animals; Cell Count; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Hippocampus; Humans; | 2013 |
The balance of striatal feedback transmission is disrupted in a model of parkinsonism.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Adrenergic Agents; Anesthetics, Local; Anim | 2013 |
Adolescent female C57BL/6 mice with vulnerability to activity-based anorexia exhibit weak inhibitory input onto hippocampal CA1 pyramidal cells.
Topics: Animals; Anorexia Nervosa; CA1 Region, Hippocampal; Disease Models, Animal; Female; gamma-Aminobutyr | 2013 |
Synthesis and anticonvulsant activity evaluation of 4-(2-alkoxy-phenyl)-2,4-dihydro-3H-1,2,4-triazol-3-ones in various experimental seizure models in mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; gamma-Aminobutyric Acid; Mice; Seizures; Triazoles | 2013 |
Neuromodulatory effect of progesterone on the dopaminergic, glutamatergic, and GABAergic activities in a male rat model of Parkinson's disease.
Topics: Amphetamine; Animals; Behavior, Animal; Disease Models, Animal; Dopamine; gamma-Aminobutyric Acid; G | 2013 |
Neuromodulatory effect of progesterone on the dopaminergic, glutamatergic, and GABAergic activities in a male rat model of Parkinson's disease.
Topics: Amphetamine; Animals; Behavior, Animal; Disease Models, Animal; Dopamine; gamma-Aminobutyric Acid; G | 2013 |
Neuromodulatory effect of progesterone on the dopaminergic, glutamatergic, and GABAergic activities in a male rat model of Parkinson's disease.
Topics: Amphetamine; Animals; Behavior, Animal; Disease Models, Animal; Dopamine; gamma-Aminobutyric Acid; G | 2013 |
Neuromodulatory effect of progesterone on the dopaminergic, glutamatergic, and GABAergic activities in a male rat model of Parkinson's disease.
Topics: Amphetamine; Animals; Behavior, Animal; Disease Models, Animal; Dopamine; gamma-Aminobutyric Acid; G | 2013 |
Noradrenaline is a stress-associated metaplastic signal at GABA synapses.
Topics: Animals; Animals, Newborn; Channelrhodopsins; Chelating Agents; Cyclic AMP-Dependent Protein Kinases | 2013 |
Antiepileptic activity of lobeline isolated from the leaf of Lobelia nicotianaefolia and its effect on brain GABA level in mice.
Topics: Animals; Anticonvulsants; Brain; Brain Chemistry; Convulsants; Disease Models, Animal; gamma-Aminobu | 2012 |
Comparing GABAergic cell populations in the thalamic reticular nucleus of normal and genetic absence epilepsy rats from Strasbourg (GAERS).
Topics: Animals; Cell Count; Disease Models, Animal; Epilepsy, Absence; GABAergic Neurons; gamma-Aminobutyri | 2013 |
Restoration of retinal structure and function after selective photocoagulation.
Topics: Animals; Disease Models, Animal; Electric Stimulation; gamma-Aminobutyric Acid; Glutamic Acid; In Vi | 2013 |
Physical exercise prevents stress-induced activation of granule neurons and enhances local inhibitory mechanisms in the dentate gyrus.
Topics: Analysis of Variance; Animals; Bicuculline; Bromodeoxyuridine; Dentate Gyrus; Disease Models, Animal | 2013 |
Altered synapses and gliotransmission in Alzheimer's disease and AD model mice.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Cerebral Cortex; Disease Model | 2013 |
Neurokinin-1 receptor-expressing neurons that contain serotonin and gamma-aminobutyric acid in the rat rostroventromedial medulla are involved in pain processing.
Topics: Animals; Biotin; Cell Count; Dextrans; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamate De | 2013 |
In vivo neurometabolic profiling to characterize the effects of social isolation and ketamine-induced NMDA antagonism: a rodent study at 7.0 T.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Gyrus Cinguli; K | 2014 |
Long-lasting distortion of GABA signaling in MS/DB neurons after binge-like ethanol exposure during initial synaptogenesis.
Topics: Animals; Animals, Newborn; Binge Drinking; Central Nervous System Depressants; Diagonal Band of Broc | 2013 |
Oxidative stress mediated neuronal damage in the corpus striatum of 6-hydroxydopamine lesioned Parkinson's rats: neuroprotection by serotonin, GABA and bone marrow cells supplementation.
Topics: Adrenergic Agents; Analysis of Variance; Animals; Bone Marrow Transplantation; Catalase; Corpus Stri | 2013 |
Altered cortical GABAA receptor composition, physiology, and endocytosis in a mouse model of a human genetic absence epilepsy syndrome.
Topics: Alleles; Animals; Benzodiazepines; Cell Membrane; Cerebral Cortex; Chlorocebus aethiops; COS Cells; | 2013 |
A back translation of pregabalin and carbamazepine against evoked and non-evoked endpoints in the rat spared nerve injury model of neuropathic pain.
Topics: Animals; Behavior, Animal; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; | 2013 |
Monocyte Chemoattractant Protein-1 upregulates GABA-induced current: evidence of modified GABAA subunit composition in cortical neurons from the G93A mouse model of Amyotrophic Lateral Sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Cells, Cultured; Cerebral Cortex; Chemokine CCL2; Disease Mo | 2013 |
The MAO inhibitor phenelzine can improve functional outcomes in mice with established clinical signs in experimental autoimmune encephalomyelitis (EAE).
Topics: Analysis of Variance; Animals; CD4 Antigens; Central Nervous System; Chromatography, High Pressure L | 2013 |
Pregabalin attenuates excitotoxicity in diabetes.
Topics: Adenosine Triphosphate; Animals; Anticonvulsants; Blood Glucose; Cell Line; Diabetic Neuropathies; D | 2013 |
Persistent overexpression of DNA methyltransferase 1 attenuating GABAergic inhibition in basolateral amygdala accounts for anxiety in rat offspring exposed perinatally to low-dose bisphenol A.
Topics: Air Pollutants, Occupational; Amygdala; Animals; Anxiety; Benzhydryl Compounds; Disease Models, Anim | 2013 |
Gabapentin-induced pharmacodynamic effects in the spinal nerve ligation model of neuropathic pain.
Topics: Amines; Analgesics; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Disease Models, Animal; | 2014 |
Increased neuronal survival in the brainstem during liver injury: role of γ-aminobutyric acid and serotonin chitosan nanoparticles.
Topics: Animals; bcl-2-Associated X Protein; Biocompatible Materials; Brain Stem; Caspase 8; Cell Survival; | 2013 |
The anticonvulsant and sedative effects of Gladiolus dalenii extracts in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Brain; Diazepam; Disease Models, Animal; Dose-Respon | 2013 |
Anticonvulsant activity of Hypericum scabrum L.; possible mechanism involved.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Free Radical Sca | 2013 |
Effects of gabapentin on thermal sensitivity following spinal nerve ligation or spinal cord compression.
Topics: Amines; Analgesics; Animals; Behavior, Animal; Conditioning, Operant; Cyclohexanecarboxylic Acids; D | 2013 |
STE20/SPS1-related proline/alanine-rich kinase is involved in plasticity of GABA signaling function in a mouse model of acquired epilepsy.
Topics: Animals; Behavior, Animal; Cells, Cultured; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Aci | 2013 |
Thyroid hormone-dependent development of the GABAergic pre- and post-synaptic components in the rat hippocampus.
Topics: Age Factors; Animals; Animals, Newborn; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Gen | 2013 |
Design of benzothiazole-1,3,4-thiadiazole conjugates: synthesis and anticonvulsant evaluation.
Topics: Animals; Anticonvulsants; Benzothiazoles; Brain; Disease Models, Animal; Drug Design; Electroshock; | 2013 |
Synergistic effects of celecoxib and bupropion in a model of chronic inflammation-related depression in mice.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antidepressive Agents; Behavior, Animal; Brain-Derive | 2013 |
Activity-dependent hyperpolarization of EGABA is absent in cutaneous DRG neurons from inflamed rats.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Action Potentials; Amino Acids; Animals; Bumetanid | 2014 |
Evidence for reduced tonic levels of GABA in the hippocampus of an animal model of ADHD, the spontaneously hypertensive rat.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Disease Models, Animal; Female; gamma-Aminob | 2013 |
Alterations of prefrontal cortex GABAergic transmission in the complex psychotic-like phenotype induced by adolescent delta-9-tetrahydrocannabinol exposure in rats.
Topics: Age Factors; Animals; Animals, Newborn; Cannabinoid Receptor Agonists; Disease Models, Animal; Dose- | 2014 |
Dysfunctional glutamatergic and γ-aminobutyric acidergic activities in prefrontal cortex of mice in social defeat model of depression.
Topics: Animals; Carbon-13 Magnetic Resonance Spectroscopy; Depression; Depressive Disorder; Disease Models, | 2014 |
Ketamine reverses stress-induced depression-like behavior and increased GABA levels in the anterior cingulate: an 11.7 T 1H-MRS study in rats.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Chromatography, High Pressure Liquid; Depressi | 2014 |
Fluoxetine in adulthood normalizes GABA release and rescues hippocampal synaptic plasticity and spatial memory in a mouse model of Down syndrome.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Biophysics; Disease Models, | 2014 |
Nanoscale intracortical iron injection induces chronic epilepsy in rodent.
Topics: Animals; Anticonvulsants; Cell Count; Cerebral Cortex; Cerebrovascular Circulation; Chronic Disease; | 2014 |
The developmental switch in GABA polarity is delayed in fragile X mice.
Topics: Animals; Blotting, Western; Critical Period, Psychological; Disease Models, Animal; Fragile X Syndro | 2014 |
GABAergic circuit dysfunction in the Drosophila Fragile X syndrome model.
Topics: Animals; Animals, Genetically Modified; Association Learning; Calcium Signaling; Cell Count; Disease | 2014 |
Synthesis and anticonvulsant activity evaluation of 7-alkoxy[1,2,4]triazolo[3,4-b]benzothiazol-3(2H)-ones.
Topics: Administration, Oral; Animals; Anticonvulsants; Disease Models, Animal; Electroshock; gamma-Aminobut | 2014 |
Hippocampal biomarkers of fear memory in an animal model of generalized anxiety disorder.
Topics: Animals; Anxiety Disorders; Avoidance Learning; Biomarkers; Brain-Derived Neurotrophic Factor; Corti | 2014 |
Correlation of 3-mercaptopropionic acid induced seizures and changes in striatal neurotransmitters monitored by microdialysis.
Topics: 3-Mercaptopropionic Acid; Animals; Basal Ganglia; Biogenic Amines; Brain Waves; Disease Models, Anim | 2014 |
Gabapentin hybrid peptides and bioconjugates.
Topics: Acylation; Amines; Analgesics; Animals; Behavior, Animal; Crystallography, X-Ray; Cyclization; Cyclo | 2014 |
Integrity of cortical perineuronal nets influences corticospinal tract plasticity after spinal cord injury.
Topics: Animals; Biomarkers; Chondroitin Sulfate Proteoglycans; Disease Models, Animal; Female; GABAergic Ne | 2015 |
Antinociceptive effects of mirtazapine, pregabalin, and gabapentin after chronic constriction injury of the infraorbital nerve in rats.
Topics: Adrenergic alpha-Antagonists; Amines; Analgesics; Animals; Cranial Nerve Injuries; Cyclohexanecarbox | 2014 |
The effects of Phα1β, a spider toxin, calcium channel blocker, in a mouse fibromyalgia model.
Topics: Animals; Brain; Calcium Channel Blockers; Diclofenac; Disease Models, Animal; Dopamine; Fibromyalgia | 2014 |
Gabapentin increases extracellular glutamatergic level in the locus coeruleus via astroglial glutamate transporter-dependent mechanisms.
Topics: Amines; Amino Acid Transport System X-AG; Animals; Astrocytes; Cyclohexanecarboxylic Acids; Disease | 2014 |
Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring.
Topics: Animals; Autistic Disorder; Behavior, Animal; Bumetanide; Chlorides; Cytoprotection; Disease Models, | 2014 |
Comparison of numbers of interneurons in three thalamic nuclei of normal and epileptic rats.
Topics: Animals; Cell Count; Disease Models, Animal; Epilepsy, Absence; gamma-Aminobutyric Acid; Interneuron | 2014 |
The effect of GABAmimetics on the duration of immobility in the forced swim test in albino mice.
Topics: Alprazolam; Animals; Depression; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; | 2014 |
Curcumol from Rhizoma Curcumae suppresses epileptic seizure by facilitation of GABA(A) receptors.
Topics: Animals; Anticonvulsants; Cells, Cultured; Curcuma; Disease Models, Animal; Dose-Response Relationsh | 2014 |
ASIC1a activation enhances inhibition in the basolateral amygdala and reduces anxiety.
Topics: Acid Sensing Ion Channels; Action Potentials; Ammonium Compounds; Amygdala; Animals; Anti-Inflammato | 2014 |
Peripheral GABAA receptor activation modulates rat tongue afferent mechanical sensitivity.
Topics: Administration, Topical; Animals; Benzodiazepines; Burning Mouth Syndrome; Disease Models, Animal; F | 2014 |
Neuronal and astrocytic metabolism in a transgenic rat model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Astrocytes; Brain; Citric Acid Cycle; Disease Models, Animal; Female; ga | 2014 |
[Effect of GABA derivative--RSMU-151 on the development of oxidative stress in rats with experimental gestosis].
Topics: Animals; Antioxidants; Brain; Disease Models, Animal; Female; GABA Agents; gamma-Aminobutyric Acid; | 2013 |
Persistent pain facilitates response to morphine reward by downregulation of central amygdala GABAergic function.
Topics: Analgesics, Opioid; Animals; Central Amygdaloid Nucleus; Chronic Pain; Conditioning, Psychological; | 2014 |
Anticonvulsant activity of pregabalin in the maximal electroshock-induced seizure assay in α2δ1 (R217A) and α2δ2 (R279A) mouse mutants.
Topics: Animals; Anticonvulsants; Calcium Channels; Disease Models, Animal; Dose-Response Relationship, Drug | 2014 |
Face-to-face comparison of the predictive validity of two models of neuropathic pain in the rat: analgesic activity of pregabalin, tramadol and duloxetine.
Topics: Analgesics; Animals; Cold Temperature; Disease Models, Animal; Duloxetine Hydrochloride; gamma-Amino | 2014 |
Simultaneous quantification of seven hippocampal neurotransmitters in depression mice by LC-MS/MS.
Topics: Animals; Chromatography, Liquid; Depressive Disorder; Disease Models, Animal; Dopamine; gamma-Aminob | 2014 |
Silicon-containing GABA derivatives, silagaba compounds, as orally effective agents for treating neuropathic pain without central-nervous-system-related side effects.
Topics: Administration, Oral; Analgesics; Animals; Brain; Disease Models, Animal; Dose-Response Relationship | 2014 |
Electrophysiological phenotypes of MeCP2 A140V mutant mouse model.
Topics: Action Potentials; Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Hippocam | 2014 |
[Effects of extracts from ziziphi spinosae semen and schisandrae chinensis fructus on amino acid neurotransmitter in rats with insomnia induced by PCPA].
Topics: Animals; Disease Models, Animal; Drugs, Chinese Herbal; Female; Fenclonine; Fruit; gamma-Aminobutyri | 2013 |
Impairment of GABA release in the hippocampus at the time of the first spontaneous seizure in the pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Calcium; Disease Models, Animal; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Hippocam | 2014 |
Ligation of mouse L4 and L5 spinal nerves produces robust allodynia without major motor function deficit.
Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Female; Gabapentin; gamma-Amin | 2015 |
Persistent nociception induces anxiety-like behavior in rodents: role of endogenous neuropeptide S.
Topics: Amygdala; Animals; Anxiety; Behavior, Animal; Disease Models, Animal; Exploratory Behavior; gamma-Am | 2014 |
Transplantation of GABAergic Interneurons into the Neonatal Primary Visual Cortex Reduces Absence Seizures in Stargazer Mice.
Topics: Animals; Calcium Channels; Disease Models, Animal; Embryo, Mammalian; Epilepsy, Absence; GABAergic N | 2015 |
Lower expression of glutamic acid decarboxylase 67 in the prefrontal cortex in schizophrenia: contribution of altered regulation by Zif268.
Topics: Adult; Animals; Antipsychotic Agents; Autopsy; Cognition Disorders; Confounding Factors, Epidemiolog | 2014 |
Antiallodynic action of 1-(3-(9H-Carbazol-9-yl)-1-propyl)-4-(2-methyoxyphenyl)-4-piperidinol (NNC05-2090), a betaine/GABA transporter inhibitor.
Topics: Animals; Betaine; CHO Cells; Cricetulus; Disease Models, Animal; Dose-Response Relationship, Drug; G | 2014 |
Combination therapy of gamma-aminobutyric acid derivative promotes proton pump inhibitor based healing of reflux esophagitis in animal model.
Topics: Animals; Disease Models, Animal; Drug Therapy, Combination; Esophagitis, Peptic; gamma-Aminobutyric | 2014 |
Mechanism underlying unaltered cortical inhibitory synaptic transmission in contrast with enhanced excitatory transmission in CaV2.1 knockin migraine mice.
Topics: Action Potentials; Animals; Calcium; Calcium Channels; Calcium Channels, N-Type; Cell Culture Techni | 2014 |
Novel use of perineural pregabalin infusion for analgesia in a rat neuropathic pain model.
Topics: Analgesics; Animals; Behavior, Animal; Calcium Channels; Disease Models, Animal; gamma-Aminobutyric | 2014 |
Human induced pluripotent stem cells improve recovery in stroke-injured aged rats.
Topics: Aging; Analysis of Variance; Animals; Brain Injuries; Cell Differentiation; Disease Models, Animal; | 2014 |
Tonic inhibition in dentate gyrus impairs long-term potentiation and memory in an Alzheimer's [corrected] disease model.
Topics: Alzheimer Disease; Animals; Astrocytes; Dentate Gyrus; Disease Models, Animal; Female; gamma-Aminobu | 2014 |
A method to enhance the magnitude of tactile hypersensitivity following spinal nerve ligation in rats.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; gamma- | 2014 |
Effects of D-series resolvins on behavioral and neurochemical changes in a fibromyalgia-like model in mice.
Topics: Analgesics; Animals; Antidepressive Agents; Brain; Depression; Disease Models, Animal; Docosahexaeno | 2014 |
Metalloproteinase inhibition prevents inhibitory synapse reorganization and seizure genesis.
Topics: Animals; Calbindin 2; Calbindins; Disease Models, Animal; Doxycycline; Extracellular Matrix; gamma-A | 2014 |
Interaction between interleukin-1 beta and angiotensin II receptor 1 in hypothalamic paraventricular nucleus contributes to progression of heart failure.
Topics: Animals; Corticotropin-Releasing Hormone; Disease Models, Animal; Disease Progression; gamma-Aminobu | 2014 |
GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Astrocytes; | 2014 |
Validation and additional support for an experimental animal model of fibromyalgia.
Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Dinoprostone; Disease Models, Animal; Female; Fibromya | 2015 |
Albumin nanoparticles for the delivery of gabapentin: preparation, characterization and pharmacodynamic studies.
Topics: Amines; Animals; Anticonvulsants; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Drug C | 2014 |
Alterations in the cholinergic system of brain stem neurons in a mouse model of Rett syndrome.
Topics: Acetylcholine; Adaptation, Physiological; Animals; Cholinergic Neurons; Disease Models, Animal; Exci | 2014 |
Brain infection with Staphylococcus aureus leads to high extracellular levels of glutamate, aspartate, γ-aminobutyric acid, and zinc.
Topics: Analysis of Variance; Animals; Aspartic Acid; Brain Abscess; Caspase 3; Disease Models, Animal; Exci | 2014 |
In vivo 1H MRS study in microlitre voxels in the hippocampus of a mouse model of Down syndrome at 11.7 T.
Topics: Animals; Brain Chemistry; Disease Models, Animal; Dominance, Cerebral; Down Syndrome; Female; gamma- | 2014 |
Inhibition of mitogen-activated protein kinases phosphorylation plays an important role in the anti-nociceptive effect of pregabalin in zymosan-induced inflammatory pain model.
Topics: Analgesics; Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Male; Mitogen-Activated Protei | 2014 |
The potential role of Morus alba leaves extract on the brain of mice infected with Schistosoma mansoni.
Topics: Acetylcholinesterase; Analysis of Variance; Animals; Antioxidants; Brain; Catalase; Chlorides; Disea | 2014 |
Defects in dendrite and spine maturation and synaptogenesis associated with an anxious-depressive-like phenotype of GABAA receptor-deficient mice.
Topics: Animals; Anxiety; Brain-Derived Neurotrophic Factor; Cells, Cultured; Cerebral Cortex; Dendrites; De | 2015 |
Analysis in conditional cannabinoid 1 receptor-knockout mice reveals neuronal subpopulation-specific effects on epileptogenesis in the kindling paradigm.
Topics: Anilides; Animals; Bromodeoxyuridine; Calcium-Calmodulin-Dependent Protein Kinase Type 1; Cannabinoi | 2015 |
In utero exposure to valproic acid changes sleep in juvenile rats: a model for sleep disturbances in autism.
Topics: Aging; Animals; Arousal; Child Development Disorders, Pervasive; Circadian Rhythm; Disease Models, A | 2014 |
Possible involvement of GABAergic and nitriergic systems for antianxiety-like activity of piperine in unstressed and stressed mice.
Topics: Alkaloids; Animals; Anti-Anxiety Agents; Anxiety; Benzodioxoles; Diazepam; Disease Models, Animal; D | 2014 |
Agrin requires specific proteins to selectively activate γ-aminobutyric acid neurons for pain suppression.
Topics: Adenoviridae; Agrin; Animals; Disease Models, Animal; Excitatory Amino Acid Agonists; gamma-Aminobut | 2014 |
Gabapentin attenuates hyperexcitability in the freeze-lesion model of developmental cortical malformation.
Topics: Age Factors; Amines; Animals; Animals, Newborn; Anticonvulsants; Calcium Channels; Cyclohexanecarbox | 2014 |
Effects of intravenous human umbilical cord blood mesenchymal stem cell therapy versus gabapentin in pentylenetetrazole-induced chronic epilepsy in rats.
Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Epilepsy; Female; Gabapentin; | 2014 |
Non-invasive diagnostic biomarkers for estimating the onset time of permanent cerebral ischemia.
Topics: Animals; Biomarkers; Brain Ischemia; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamine; Hum | 2014 |
The effect of omega-3 on cognition in hypothyroid adult male rats.
Topics: Animals; Antioxidants; Behavior, Animal; Brain; Calcium Channels, L-Type; Carbimazole; Cognition; Co | 2014 |
Development and pharmacological characterization of a model of sleep disruption-induced hypersensitivity in the rat.
Topics: Amines; Animals; Anti-Anxiety Agents; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapenti | 2015 |
Pregabalin role in inhibition of morphine analgesic tolerance and physical dependency in rats.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Toleranc | 2014 |
Effect of spontaneous seizures on GABAA receptor α4 subunit expression in an animal model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Pilocarpine; Rats | 2014 |
Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methods.
Topics: Amines; Amitriptyline; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Cyclohexanecarboxyli | 2014 |
BDNF modifies hippocampal KCC2 and NKCC1 expression in a temporal lobe epilepsy model.
Topics: Animals; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Epilepsy, Temporal Lobe; gamma-A | 2014 |
Gastrointestinal intervention ameliorates high blood pressure through antagonizing overdrive of the sympathetic nerve in hypertensive patients and rats.
Topics: Adult; Animals; Biomarkers; Blood Pressure; Cardiovascular System; Cold-Shock Response; Diabetes Mel | 2014 |
Gabapentin reverses central hypersensitivity and suppresses medial prefrontal cortical glucose metabolism in rats with neuropathic pain.
Topics: Amines; Animals; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Fluorodeoxyglucose F18; | 2014 |
Anesthesia influences neuronal activity and drug effectiveness in neuropathic rats.
Topics: Action Potentials; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; | 2014 |
Evaluation of impact-induced traumatic brain injury in the Göttingen Minipig using two input modes.
Topics: Animals; Aspartic Acid; Brain Injuries; Dipeptides; Disease Models, Animal; Female; gamma-Aminobutyr | 2014 |
Amygdala NRG1-ErbB4 is critical for the modulation of anxiety-like behaviors.
Topics: Amygdala; Animals; Anxiety; Disease Models, Animal; Enzyme Inhibitors; Exploratory Behavior; Feeding | 2015 |
Chronic intermittent hypoxia alters neurotransmission from lateral paragigantocellular nucleus to parasympathetic cardiac neurons in the brain stem.
Topics: Animals; Brain Stem; Disease Models, Animal; Electric Stimulation; Female; gamma-Aminobutyric Acid; | 2015 |
Sub-chronic copper pretreatment reduces oxidative damage in an experimental Huntington's disease model.
Topics: Animals; Apomorphine; Copper; Disease Models, Animal; gamma-Aminobutyric Acid; Huntington Disease; L | 2014 |
Neuroprotective role of liver growth factor "LGF" in an experimental model of cerebellar ataxia.
Topics: Animals; Antigens, Nuclear; Bilirubin; Calbindins; Cell Differentiation; Cerebellar Ataxia; Cerebell | 2014 |
Pregabalin reduces acute inflammatory and persistent pain associated with nerve injury and cancer in rat models of orofacial pain.
Topics: Acute Pain; Analgesics; Animals; Anti-Inflammatory Agents; Capsaicin; Carrageenan; Chronic Pain; Dis | 2014 |
Persistent reduction of hippocampal glutamine synthetase expression after status epilepticus in immature rats.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Glutamate | 2014 |
Post-stroke pain hypersensitivity induced by experimental thalamic hemorrhage in rats is region-specific and demonstrates limited efficacy of gabapentin.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; gamma- | 2014 |
Effect of catgut implantation at acupoints on GABA(B) and mGluR1 expressions in brain stem of rats with spasticity after stroke. .
Topics: Acupuncture Points; Acupuncture Therapy; Animals; Brain Stem; Catgut; Disease Models, Animal; gamma- | 2014 |
The role of calcitonin gene-related peptide in post-stroke depression in chronic mild stress-treated ischemic rats.
Topics: Anhedonia; Animals; Antidepressive Agents; Brain Ischemia; Calcitonin Gene-Related Peptide; Chronic | 2015 |
A2A adenosine receptor deletion is protective in a mouse model of Tauopathy.
Topics: Adenosine A2 Receptor Antagonists; Alzheimer Disease; Animals; Cognition Disorders; Disease Models, | 2016 |
α₄β₂ Nicotinic receptor stimulation of the GABAergic system within the orbitofrontal cortex ameliorates the severe crossmodal object recognition impairment in ketamine-treated rats: implications for cognitive dysfunction in schizophrenia.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Ketamine; Male; Neuropsycho | 2015 |
Ketamine Administration During the Second Postnatal Week Alters Synaptic Properties of Fast-Spiking Interneurons in the Medial Prefrontal Cortex of Adult Mice.
Topics: Action Potentials; Animals; Animals, Newborn; Disease Models, Animal; Excitatory Postsynaptic Potent | 2016 |
Attenuation of persistent pain-related behavior by fatty acid amide hydrolase (FAAH) inhibitors in a rat model of HIV sensory neuropathy.
Topics: Amidohydrolases; Amines; Analgesics; Animals; Benzamides; Carbamates; Cyclohexanecarboxylic Acids; D | 2015 |
Exocytosis regulates trafficking of GABA and glycine heterotransporters in spinal cord glutamatergic synapses: a mechanism for the excessive heterotransporter-induced release of glutamate in experimental amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Exocytosis; Female; GABA Plasma Memb | 2015 |
Chronic stress shifts the GABA reversal potential in the hippocampus and increases seizure susceptibility.
Topics: Acute Disease; Animals; Bumetanide; Chronic Disease; Corticosterone; Disease Models, Animal; gamma-A | 2015 |
Effects of eslicarbazepine acetate on acute and chronic latrunculin A-induced seizures and extracellular amino acid levels in the mouse hippocampus.
Topics: Acute Disease; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Bridged Bicyclo Compounds, Hete | 2014 |
The role of the GABA-A receptor of the adjacent intact dorsal root ganglion neurons in rats with neuropathic pain.
Topics: Animals; Biophysics; Cell Size; Cells, Cultured; Disease Models, Animal; Electric Stimulation; GABA- | 2014 |
The mast cell stabilizer sodium cromoglycate reduces histamine release and status epilepticus-induced neuronal damage in the rat hippocampus.
Topics: Analysis of Variance; Animals; Anti-Asthmatic Agents; Anticonvulsants; Cell Count; Chromatography, H | 2015 |
Inhibition of anandamide hydrolysis enhances noradrenergic and GABAergic transmission in the prefrontal cortex and basolateral amygdala of rats subjected to acute swim stress.
Topics: Analysis of Variance; Animals; Arachidonic Acids; Basolateral Nuclear Complex; Benzamides; Carbamate | 2015 |
In vitro anti-inflammatory properties of fermented pepino (Solanum muricatum) milk by γ-aminobutyric acid-producing Lactobacillus brevis and an in vivo animal model for evaluating its effects on hypertension.
Topics: Animals; Anti-Inflammatory Agents; Blood Pressure; Disease Models, Animal; Fermentation; Fruit; Func | 2016 |
Loss of the preferential control over the striato-nigral direct pathway by striatal NMDA receptors in a rat model of Parkinson's disease.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Globus Pallidus; Male; Microdialysis; N-Me | 2015 |
Cystathionine-β-Synthase Gene Transfer Into Rostral Ventrolateral Medulla Exacerbates Hypertension via Nitric Oxide in Spontaneously Hypertensive Rats.
Topics: Animals; Blood Pressure; Cystathionine beta-Synthase; Disease Models, Animal; Enzyme Induction; gamm | 2015 |
GABAergic control of depression-related brain states.
Topics: Animals; Antidepressive Agents; Brain; Depressive Disorder, Major; Disease Models, Animal; gamma-Ami | 2015 |
In vivo two-photon imaging of structural dynamics in the spinal dorsal horn in an inflammatory pain model.
Topics: Acute Disease; Amines; Animals; Calcium Channel Blockers; Calcium Channels; Cyclohexanecarboxylic Ac | 2015 |
Dorsal raphe 5-HT(2C) receptor and GABA networks regulate anxiety produced by cocaine withdrawal.
Topics: Action Potentials; Animals; Anxiety; Cocaine; Disease Models, Animal; Dopamine Uptake Inhibitors; Do | 2015 |
CRF2 Receptor Deficiency Eliminates the Long-Lasting Vulnerability of Motivational States Induced by Opiate Withdrawal.
Topics: Animals; Anxiety; Brain; Conditioning, Operant; Disease Models, Animal; Dopamine; Female; gamma-Amin | 2015 |
Comprehensive analysis of the GABAergic system gene expression profile in the anterior cingulate cortex of mice with Paclitaxel-induced neuropathic pain.
Topics: Animals; Disease Models, Animal; Drug-Related Side Effects and Adverse Reactions; GABA Plasma Membra | 2015 |
Stability of the synaptic structure in the hippocampus of BALB/c mice with allergic rhinitis.
Topics: Administration, Intranasal; Allergens; Animals; Dendritic Spines; Disease Models, Animal; gamma-Amin | 2015 |
Differences in cisplatin-induced mechanical allodynia in male and female mice.
Topics: Amines; Analgesics; Animals; Antineoplastic Agents; Cisplatin; Cyclohexanecarboxylic Acids; Disease | 2015 |
Functional and structural deficits of the dentate gyrus network coincide with emerging spontaneous seizures in an Scn1a mutant Dravet Syndrome model during development.
Topics: Action Potentials; Age Factors; Animals; Animals, Newborn; Dentate Gyrus; Disease Models, Animal; Ep | 2015 |
Complete Freund's adjuvant-induced reduction of exploratory activity in a novel environment as an objective nociceptive endpoint for sub-acute inflammatory pain model in rats.
Topics: Adjuvants, Immunologic; Amines; Analgesics; Animals; Behavior, Animal; Celecoxib; Cyclohexanecarboxy | 2015 |
Involvement of medullary GABAergic system in extraterritorial neuropathic pain mechanisms associated with inferior alveolar nerve transection.
Topics: Acetates; Action Potentials; Animals; Disease Models, Animal; Extracellular Signal-Regulated MAP Kin | 2015 |
¹H- and ¹³C-NMR spectroscopy of Thy-1-APPSL mice brain extracts indicates metabolic changes in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Br | 2015 |
The excitatory synaptic transmission of the nucleus of solitary tract was potentiated by chronic myocardial infarction in rats.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Excitatory Postsyn | 2015 |
Transplant-mediated enhancement of spinal cord GABAergic inhibition reverses paclitaxel-induced mechanical and heat hypersensitivity.
Topics: Activating Transcription Factor 3; Animals; Antineoplastic Agents, Phytogenic; Cell Count; Cell Tran | 2015 |
Plasticity of motor network and function in the absence of corticospinal projection.
Topics: Acetylcholine; Animals; Brain Diseases; Cadherins; Choline O-Acetyltransferase; Disease Models, Anim | 2015 |
Role of the potassium chloride cotransporter isoform 2-mediated spinal chloride homeostasis in a rat model of visceral hypersensitivity.
Topics: Animals; Behavior, Animal; Carboxylic Acids; Chlorides; Disease Models, Animal; Down-Regulation; GAB | 2015 |
Synaptic GABA release prevents GABA transporter type-1 reversal during excessive network activity.
Topics: Animals; Disease Models, Animal; Epilepsy; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyr | 2015 |
Increased expression of HCN2 channel protein in L4 dorsal root ganglion neurons following axotomy of L5- and inflammation of L4-spinal nerves in rats.
Topics: Amines; Animals; Axotomy; Cyclohexanecarboxylic Acids; Disease Models, Animal; Excitatory Amino Acid | 2015 |
[Comparative study of the effects of new neuroactive amino acid derivatives on the postnatal development of the rat's offspring with experimental preeclampsia].
Topics: Animals; Animals, Newborn; Behavior, Animal; Cognition; Disease Models, Animal; Female; gamma-Aminob | 2014 |
GABAergic regulation of cerebellar NG2 cell development is altered in perinatal white matter injury.
Topics: Action Potentials; Animals; Animals, Newborn; Asphyxia Neonatorum; Carbachol; Cell Count; Cells, Cul | 2015 |
Blocking the GABA transporter GAT-1 ameliorates spinal GABAergic disinhibition and neuropathic pain induced by paclitaxel.
Topics: Animals; Antineoplastic Agents, Phytogenic; Blotting, Western; Disease Models, Animal; GABA Plasma M | 2015 |
Anticonvulsant and Sedative Effects of Eudesmin isolated from Acorus tatarinowii on mice and rats.
Topics: Acorus; Animals; Anticonvulsants; Brain; Caspase 3; Disease Models, Animal; Electroshock; Epilepsy; | 2015 |
Gene Transfer of Glutamic Acid Decarboxylase 67 by Herpes Simplex Virus Vectors Suppresses Neuropathic Pain Induced by Human Immunodeficiency Virus gp120 Combined with ddC in Rats.
Topics: Animals; CCAAT-Enhancer-Binding Protein-beta; Cyclic AMP Response Element-Binding Protein; Decarboxy | 2015 |
Engagement of the GABA to KCC2 signaling pathway contributes to the analgesic effects of A3AR agonists in neuropathic pain.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Analgesics; Animals; Disease Models, Animal; Dose-Respons | 2015 |
Receptor Reserve Moderates Mesolimbic Responses to Opioids in a Humanized Mouse Model of the OPRM1 A118G Polymorphism.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Dopamine; gamma-Aminobutyric Acid; HEK293 Cells | 2015 |
GABA acting on GABAB receptors located in a medullary pain facilitatory area enhances nociceptive behaviors evoked by intraplantar formalin injection.
Topics: Animals; Baclofen; Disease Models, Animal; Formaldehyde; GABA-B Receptor Agonists; GABA-B Receptor A | 2015 |
Carbonic anhydrase inhibition by acetazolamide reduces in vitro epileptiform synchronization.
Topics: 4-Aminopyridine; Acetazolamide; Animals; Anticonvulsants; Carbonic Anhydrase Inhibitors; Carbonic An | 2015 |
Enlargement of Axo-Somatic Contacts Formed by GAD-Immunoreactive Axon Terminals onto Layer V Pyramidal Neurons in the Medial Prefrontal Cortex of Adolescent Female Mice Is Associated with Suppression of Food Restriction-Evoked Hyperactivity and Resilience
Topics: Animals; Anorexia; Axons; Diet, Carbohydrate-Restricted; Disease Models, Animal; Female; gamma-Amino | 2016 |
Transcranial focal electrical stimulation reduces the convulsive expression and amino acid release in the hippocampus during pilocarpine-induced status epilepticus in rats.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Pilocarp | 2015 |
Absence of aryl hydrocarbon receptors increases endogenous kynurenic acid levels and protects mouse brain against excitotoxic insult and oxidative stress.
Topics: Acetyltransferases; Animals; Basic Helix-Loop-Helix Transcription Factors; Brain; Disease Models, An | 2015 |
GABAB receptor upregulates fragile X mental retardation protein expression in neurons.
Topics: Animals; Baclofen; Disease Models, Animal; Fragile X Mental Retardation Protein; Fragile X Syndrome; | 2015 |
Early Adolescent Emergence of Reversal Learning Impairments in Isolation-Reared Rats.
Topics: Age Factors; Animals; Behavior, Animal; Cognition Disorders; Disease Models, Animal; Female; gamma-A | 2015 |
Striatal astrocytes transdifferentiate into functional mature neurons following ischemic brain injury.
Topics: Animals; Astrocytes; Brain Ischemia; Choline O-Acetyltransferase; Corpus Striatum; Disease Models, A | 2015 |
Prenatal stress, regardless of concurrent escitalopram treatment, alters behavior and amygdala gene expression of adolescent female rats.
Topics: Amygdala; Animals; Anxiety; Citalopram; Corticosterone; Disease Models, Animal; Estradiol; Female; g | 2015 |
Enhanced astroglial GABA uptake attenuates tonic GABAA inhibition of the presympathetic hypothalamic paraventricular nucleus neurons in heart failure.
Topics: Action Potentials; Animals; Astrocytes; Disease Models, Animal; GABA Plasma Membrane Transport Prote | 2015 |
Hyperactivity and impaired attention in Gamma aminobutyric acid transporter subtype 1 gene knockout mice.
Topics: Animals; Anxiety; Attention Deficit Disorder with Hyperactivity; Disease Models, Animal; DNA-Binding | 2015 |
Increased extracellular levels of glutamate in the hippocampus of chronically epileptic rats.
Topics: Animals; Chromatography, High Pressure Liquid; Chronic Disease; Disease Models, Animal; Electroencep | 2015 |
Activation of AMPA Receptors Mediates the Antidepressant Action of Deep Brain Stimulation of the Infralimbic Prefrontal Cortex.
Topics: Animals; Deep Brain Stimulation; Depressive Disorder; Disease Models, Animal; Dopamine; gamma-Aminob | 2016 |
Decrease in pyridoxal-5'-phosphate concentration and increase in pyridoxal concentration in rat plasma by 4'-O-methylpyridoxine administration.
Topics: Animals; Brain; Disease Models, Animal; Foodborne Diseases; gamma-Aminobutyric Acid; Ginkgo biloba; | 2015 |
Prenatal Nicotine Exposure Impairs the Proliferation of Neuronal Progenitors, Leading to Fewer Glutamatergic Neurons in the Medial Prefrontal Cortex.
Topics: Animals; Cell Cycle; Cell Movement; Cognition Disorders; Disease Models, Animal; Female; gamma-Amino | 2016 |
Spontaneous Chronic Pain After Experimental Thoracotomy Revealed by Conditioned Place Preference: Morphine Differentiates Tactile Evoked Pain From Spontaneous Pain.
Topics: Amines; Analgesics; Analysis of Variance; Animals; Conditioning, Operant; Cyclohexanecarboxylic Acid | 2015 |
A streptozotocin-induced diabetic neuropathic pain model for static or dynamic mechanical allodynia and vulvodynia: validation using topical and systemic gabapentin.
Topics: Administration, Topical; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Diabetes Mellitus | 2015 |
Neuroligin-2 Expression in the Prefrontal Cortex is Involved in Attention Deficits Induced by Peripubertal Stress.
Topics: Animals; Attention; Attention Deficit Disorder with Hyperactivity; Cell Adhesion Molecules, Neuronal | 2016 |
[The Analgesia of Oxymatrine Affecting Calcium Channel and GABA Release].
Topics: Alkaloids; Analgesia; Animals; Calcium; Calcium Channels; Disease Models, Animal; gamma-Aminobutyric | 2015 |
Alterations in Brain Inflammation, Synaptic Proteins, and Adult Hippocampal Neurogenesis during Epileptogenesis in Mice Lacking Synapsin2.
Topics: Animals; Carrier Proteins; Cell Adhesion Molecules, Neuronal; Cerebral Cortex; Chemokines; Cytokines | 2015 |
Cerebellar synaptogenesis is compromised in mouse models of DYT1 dystonia.
Topics: Age Factors; Animals; Animals, Newborn; Cells, Cultured; Cerebellum; Coculture Techniques; Disease M | 2015 |
Eltoprazine prevents levodopa-induced dyskinesias by reducing striatal glutamate and direct pathway activity.
Topics: Adrenergic Agents; Animals; Antiparkinson Agents; Corpus Striatum; Disease Models, Animal; Dopamine; | 2015 |
Involvement of chondroitin 6-sulfation in temporal lobe epilepsy.
Topics: Animals; Carbohydrate Sulfotransferases; Cerebral Cortex; Disease Models, Animal; Epilepsy, Temporal | 2015 |
Effect of a Novel, Orally Active Matrix Metalloproteinase-2 and -9 Inhibitor in Spinal and Trigeminal Rat Models of Neuropathic Pain.
Topics: Administration, Oral; Amines; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapent | 2015 |
Early environmental therapy rescues brain development in a mouse model of Down syndrome.
Topics: Animals; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Down Syndrome; Environment; Evok | 2015 |
[STUDYING NEUROPROTECTIVE ACTIVITY OF GABA CONJUGATE WITH ARACHIDONIC ACID UNDER CONDITIONS OF LOCAL PERMANENT BRAIN ISCHEMIA IN RATS].
Topics: Animals; Arachidonic Acids; Brain Ischemia; Disease Models, Animal; GABA Agents; gamma-Aminobutyric | 2015 |
Rescue of deficient amygdala tonic γ-aminobutyric acidergic currents in the Fmr-/y mouse model of fragile X syndrome by a novel γ-aminobutyric acid type A receptor-positive allosteric modulator.
Topics: Amygdala; Animals; Animals, Newborn; CHO Cells; Cricetulus; Disease Models, Animal; Dose-Response Re | 2016 |
GABAergic control of the activity of the central nucleus of the amygdala in low- and high-anxiety rats.
Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Basolateral Nuclear Complex; Central Amygdaloid Nuc | 2015 |
Neuregulin 1 protects against ischemic brain injury via ErbB4 receptors by increasing GABAergic transmission.
Topics: Animals; Apoptosis; Brain Injuries; Cell Hypoxia; Cells, Cultured; Disease Models, Animal; GABA Agon | 2015 |
Pharmacological characteristics of the hind paw weight bearing difference induced by chronic constriction injury of the sciatic nerve in rats.
Topics: Amines; Analgesics; Animals; Chronic Disease; Cyclohexanecarboxylic Acids; Disease Models, Animal; G | 2009 |
Loss of Striatonigral GABAergic Presynaptic Inhibition Enables Motor Sensitization in Parkinsonian Mice.
Topics: Adrenergic Agents; Animals; Bacterial Proteins; Channelrhodopsins; Corpus Striatum; Disease Models, | 2015 |
Gabapentin, an Analgesic Used Against Cancer-Associated Neuropathic Pain: Effects on Prostate Cancer Progression in an In Vivo Rat Model.
Topics: Amines; Analgesics; Animals; Carcinogenesis; Cells, Cultured; Cyclohexanecarboxylic Acids; Disease M | 2016 |
Long-term effects of neonatal exposure to MK-801 on recognition memory and excitatory-inhibitory balance in rat hippocampus.
Topics: Animals; Animals, Newborn; Cell Count; Disease Models, Animal; Dizocilpine Maleate; Exploratory Beha | 2015 |
Exaggerated Nighttime Sleep and Defective Sleep Homeostasis in a Drosophila Knock-In Model of Human Epilepsy.
Topics: Animals; Animals, Genetically Modified; Circadian Rhythm; Disease Models, Animal; Disease Susceptibi | 2015 |
Neurotransmission to parasympathetic cardiac vagal neurons in the brain stem is altered with left ventricular hypertrophy-induced heart failure.
Topics: Animals; Brain Stem; Disease Models, Animal; Excitatory Postsynaptic Potentials; GABAergic Neurons; | 2015 |
Developmental and degenerative modulation of GABAergic transmission in the mouse hippocampus.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Disease Models, Animal; gamma-Aminobut | 2015 |
Involvement of the GABAergic system in the neuroprotective and sedative effects of acacetin 7-O-glucoside in rodents.
Topics: Animals; Anticonvulsants; CA1 Region, Hippocampal; Cerebral Cortex; Disease Models, Animal; Dose-Res | 2015 |
Retinal development impairment and degenerative alterations in adult rats subjected to post-natal malnutrition.
Topics: Age Factors; Animals; Animals, Newborn; Cell Count; Cell Death; Cell Proliferation; Disease Models, | 2015 |
Reward related neurotransmitter changes in a model of depression: An in vivo microdialysis study.
Topics: Animals; Depression; Disease Models, Animal; Dopamine; Dopamine Agents; gamma-Aminobutyric Acid; Glu | 2015 |
Peripheral Neuritis Trauma in Pigs: A Neuropathic Pain Model.
Topics: Amines; Analgesics; Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Calcitonin Gene-Re | 2016 |
Caffeine prevents antihyperalgesic effect of gabapentin in an animal model of CRPS-I: evidence for the involvement of spinal adenosine A1 receptor.
Topics: Amines; Analgesics; Animals; Caffeine; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapent | 2015 |
Cadherin-13, a risk gene for ADHD and comorbid disorders, impacts GABAergic function in hippocampus and cognition.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Cadherins; Disease Models, Animal; gamma-Ami | 2015 |
Toxoplasma gondii Infections Alter GABAergic Synapses and Signaling in the Central Nervous System.
Topics: Animals; Brain; Cell Movement; Disease Models, Animal; GABAergic Neurons; gamma-Aminobutyric Acid; G | 2015 |
Gabapentin Effects on PKC-ERK1/2 Signaling in the Spinal Cord of Rats with Formalin-Induced Visceral Inflammatory Pain.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amines; Animals; Behavior, Animal; Cell Membrane; Cyc | 2015 |
NF-κB Inhibition Resolves Cognitive Deficits in Experimental Type 2 Diabetes Mellitus through CREB and Glutamate/GABA Neurotransmitters Pathway.
Topics: Animals; Avoidance Learning; Blood Glucose; Brain; Cognition Disorders; CREB-Binding Protein; Diabet | 2016 |
The effect of gabapentin and ketorolac on allodynia and conditioned place preference in antibody-induced inflammation.
Topics: Amines; Analgesics; Animals; Arthritis; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapen | 2016 |
BMSCs transplantation improves cognitive impairment via up-regulation of hippocampal GABAergic system in a rat model of chronic cerebral hypoperfusion.
Topics: Animals; Bone Marrow Transplantation; Brain Ischemia; Carotid Artery Diseases; Cell Movement; Chroni | 2015 |
Effects of Propofol on Excitatory and Inhibitory Amino Acid Neurotransmitter Balance in Rats with Neurogenic Pulmonary Edema Induced by Subarachnoid Hemorrhage.
Topics: Animals; Brain; Brain Edema; Disease Models, Animal; Excitatory Amino Acids; gamma-Aminobutyric Acid | 2016 |
Antinociceptive Grayanoids from the Roots of Rhododendron molle.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Diterpenes; Drugs, | 2015 |
Co-administration of morphine and gabapentin leads to dose dependent synergistic effects in a rat model of postoperative pain.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Rela | 2016 |
Decreased acylcarnitine content improves insulin sensitivity in experimental mice models of insulin resistance.
Topics: Animals; Blood Glucose; Carnitine; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diet, High-Fa | 2016 |
Antidepressive-like effects and antioxidant activity of green tea and GABA green tea in a mouse model of post-stroke depression.
Topics: Animals; Antidepressive Agents; Antioxidants; Brain; Camellia sinensis; Depression; Disease Models, | 2016 |
Compromising the phosphodependent regulation of the GABAAR β3 subunit reproduces the core phenotypes of autism spectrum disorders.
Topics: Alanine; Animals; Autism Spectrum Disorder; Behavior, Animal; Biotinylation; Cell Membrane; Dendriti | 2015 |
The pervasive reduction of GABA-mediated synaptic inhibition of principal neurons in the hippocampus during status epilepticus.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Hippocampus; Inhibitory Postsynaptic Poten | 2016 |
Diphenyl diselenide ameliorates monosodium glutamate induced anxiety-like behavior in rats by modulating hippocampal BDNF-Akt pathway and uptake of GABA and serotonin neurotransmitters.
Topics: Animals; Animals, Newborn; Anti-Anxiety Agents; Anxiety; Benzene Derivatives; Brain-Derived Neurotro | 2016 |
Target-selectivity of parvalbumin-positive interneurons in layer II of medial entorhinal cortex in normal and epileptic animals.
Topics: Animals; Calbindins; Cell Adhesion Molecules, Neuronal; Cholecystokinin; Disease Models, Animal; Ent | 2016 |
Pharmacological characterization of intraplantar Complete Freund's Adjuvant-induced burrowing deficits.
Topics: Amines; Analgesics; Animals; Antibodies; Behavior, Animal; Celecoxib; Cyclohexanecarboxylic Acids; D | 2016 |
Involvement of NO/cGMP pathway in the antidepressant-like effect of gabapentin in mouse forced swimming test.
Topics: Amines; Animals; Antidepressive Agents; Behavior, Animal; Cyclic GMP; Cyclohexanecarboxylic Acids; D | 2016 |
Gabapentinoid Insensitivity after Repeated Administration is Associated with Down-Regulation of the α(2)δ-1 Subunit in Rats with Central Post-Stroke Pain Hypersensitivity.
Topics: Amines; Analgesics; Animals; Blotting, Western; Calcium Channels; Cyclohexanecarboxylic Acids; Disea | 2016 |
Analysis of the behavioral, cellular and molecular characteristics of pain in severe rodent spinal cord injury.
Topics: Amines; Animals; Calcitonin Gene-Related Peptide; Calcium-Binding Proteins; Carbenoxolone; Connexin | 2016 |
Maternal immune activation leads to selective functional deficits in offspring parvalbumin interneurons.
Topics: Animals; Disease Models, Animal; Female; GABAergic Neurons; gamma-Aminobutyric Acid; Humans; Immunit | 2016 |
A New Computational Model for Neuro-Glio-Vascular Coupling: Astrocyte Activation Can Explain Cerebral Blood Flow Nonlinear Response to Interictal Events.
Topics: Action Potentials; Algorithms; Animals; Astrocytes; Blood Vessels; Brain; Cerebrovascular Circulatio | 2016 |
Antinociceptive Interaction of Tramadol with Gabapentin in Experimental Mononeuropathic Pain.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Rela | 2016 |
Optical isomers of phenibut inhibit [H(3)]-Gabapentin binding in vitro and show activity in animal models of chronic pain.
Topics: Amines; Animals; Chronic Pain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Freund's Adjuvan | 2016 |
Naringin Protects Ovalbumin-Induced Airway Inflammation in a Mouse Model of Asthma.
Topics: Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Antioxidants; Asthma; Bronchoalveolar Lava | 2016 |
The expression and distribution of seizure-related and synaptic proteins in the insular cortex of rats genetically prone to audiogenic seizures.
Topics: Acoustic Stimulation; Animals; Animals, Inbred Strains; Cerebral Cortex; Disease Models, Animal; Epi | 2015 |
Essential fatty acid-rich diets protect against striatal oxidative damage induced by quinolinic acid in rats.
Topics: Animals; Body Weight; Cholesterol; Corpus Striatum; Disease Models, Animal; Fatty Acids, Essential; | 2017 |
Continuous bilateral infusion of vigabatrin into the subthalamic nucleus: Effects on seizure threshold and GABA metabolism in two rat models.
Topics: Animals; Basal Ganglia; Disease Models, Animal; Electric Stimulation; Female; gamma-Aminobutyric Aci | 2016 |
Cortical Gene Expression After a Conditional Knockout of 67 kDa Glutamic Acid Decarboxylase in Parvalbumin Neurons.
Topics: Animals; Behavior, Animal; Cerebral Cortex; Disease Models, Animal; Female; GABAergic Neurons; gamma | 2016 |
Decreased Expression of Sox-1 in Cerebellum of Rat with Generalized Seizures Induced by Kindling Model.
Topics: Amygdala; Animals; Blotting, Western; Cerebellum; Chromatography, High Pressure Liquid; Disease Mode | 2016 |
Aminochrome induces dopaminergic neuronal dysfunction: a new animal model for Parkinson's disease.
Topics: Adenosine Triphosphate; Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Corpus Stri | 2016 |
eEF2K/eEF2 Pathway Controls the Excitation/Inhibition Balance and Susceptibility to Epileptic Seizures.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Conditioning, Psychological; Disease Models, Animal; Elon | 2017 |
Prenatal alcohol exposure alters synaptic activity of adult hippocampal dentate granule cells under conditions of enriched environment.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Environment; Ethanol; Female; Fetal Alcohol Spectrum | 2016 |
Role of interleukin-10 (IL-10) in regulation of GABAergic transmission and acute response to ethanol.
Topics: Animals; Binge Drinking; Brain; Cells, Cultured; Central Nervous System Depressants; Disease Models, | 2016 |
Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition.
Topics: Animals; Disease Models, Animal; Exons; gamma-Aminobutyric Acid; Hyperalgesia; K Cl- Cotransporters; | 2016 |
Improvements in impaired GABA and GAD65/67 production in the spinal dorsal horn contribute to exercise-induced hypoalgesia in a mouse model of neuropathic pain.
Topics: Animals; Behavior, Animal; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamate Decarboxylase; | 2016 |
Antinociceptive Interactions Between Meloxicam and Gabapentin in Neuropathic Pain Depend on the Ratio used in Combination in Rats.
Topics: Amines; Analgesics; Animals; Area Under Curve; Cyclohexanecarboxylic Acids; Disease Models, Animal; | 2016 |
Thirst Is Associated with Suppression of Habenula Output and Active Stress Coping: Is there a Role for a Non-canonical Vasopressin-Glutamate Pathway?
Topics: Animals; Cats; Colchicine; Disease Models, Animal; Fear; gamma-Aminobutyric Acid; Glutamate Decarbox | 2016 |
Neurochemical Changes Associated with Stress-Induced Sleep Disturbance in Rats: In Vivo and In Vitro Measurements.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Disease Models, Animal; Dopamine; gamma-Aminob | 2016 |
Rapamycin/GABA combination treatment ameliorates diabetes in NOD mice.
Topics: Animals; Blotting, Western; Diabetes Mellitus, Type 1; Disease Models, Animal; Drug Therapy, Combina | 2016 |
Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia.
Topics: Animals; Anti-Inflammatory Agents; Blotting, Western; Cell Membrane; Cerebellum; Disease Models, Ani | 2016 |
Altered development in GABA co-release shapes glycinergic synaptic currents in cultured spinal slices of the SOD1(G93A) mouse model of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Embryo, Mammalian; Female; gamma-Ami | 2016 |
Recovery effect of pre-germinated brown rice on the alteration of sperm quality, testicular structure and androgen receptor expression in rat model of depression.
Topics: Animals; Antidepressive Agents; Depressive Disorder; Disease Models, Animal; Fluoxetine; gamma-Amino | 2017 |
Chemical Control of Grafted Human PSC-Derived Neurons in a Mouse Model of Parkinson's Disease.
Topics: Animals; Cell Differentiation; Cell Line; Clozapine; Disease Models, Animal; Dopaminergic Neurons; D | 2016 |
[THE EFFECT OF PERINATAL HYPOXIA ON THE STRUCTURE OF BLOOD-BRAIN BARRIER IN RATS TREATED WITH SALIFEN].
Topics: Animals; Animals, Newborn; Blood-Brain Barrier; Capillaries; Disease Models, Animal; Endothelium, Va | 2015 |
Gabapentin prevents behavioral changes on the amphetamine-induced animal model of schizophrenia.
Topics: Amines; Amphetamine; Animals; Behavior, Animal; Calcium Channel Blockers; Cyclohexanecarboxylic Acid | 2016 |
GABAB receptors in the hippocampal dentate gyrus are involved in spatial learning and memory impairment in a rat model of vascular dementia.
Topics: Animals; Baclofen; Dementia, Vascular; Dentate Gyrus; Disease Models, Animal; GABA Antagonists; GABA | 2016 |
Altered Function of the DnaJ Family Cochaperone DNJ-17 Modulates Locomotor Circuit Activity in a Caenorhabditis elegans Seizure Model.
Topics: Aldicarb; Amino Acid Sequence; Amino Acid Substitution; Animals; Behavior, Animal; Caenorhabditis el | 2016 |
Early GABAergic transmission defects in the external globus pallidus and rest/activity rhythm alteration in a mouse model of Huntington's disease.
Topics: Aging; Animals; Disease Models, Animal; Disease Progression; gamma-Aminobutyric Acid; Globus Pallidu | 2016 |
Insular balance of glutamatergic and GABAergic signaling modulates pain processing.
Topics: Analysis of Variance; Animals; Avoidance Learning; Cerebral Cortex; Disease Models, Animal; Excitato | 2016 |
Reductions in tonic GABAergic current in substantia gelatinosa neurons and GABA
Topics: Animals; Constriction; Disease Models, Animal; gamma-Aminobutyric Acid; Lumbar Vertebrae; Mice; Neur | 2016 |
Medial plantar nerve ligation as a novel model of neuropathic pain in mice: pharmacological and molecular characterization.
Topics: Activating Transcription Factor 3; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease | 2016 |
Low-frequency electrical stimulation enhances the effectiveness of phenobarbital on GABAergic currents in hippocampal slices of kindled rats.
Topics: Animals; Anticonvulsants; CA1 Region, Hippocampal; Combined Modality Therapy; Disease Models, Animal | 2016 |
Chronic Stress Increases Prefrontal Inhibition: A Mechanism for Stress-Induced Prefrontal Dysfunction.
Topics: Animals; Behavior, Animal; Chronic Disease; Disease Models, Animal; gamma-Aminobutyric Acid; Glutami | 2016 |
mir-500-Mediated GAD67 Downregulation Contributes to Neuropathic Pain.
Topics: Action Potentials; Animals; Antagomirs; Antineoplastic Agents, Phytogenic; Disease Models, Animal; D | 2016 |
The Antinociceptive Effects of Tramadol and/or Gabapentin on Rat Neuropathic Pain Induced by a Chronic Constriction Injury.
Topics: Amines; Analgesics; Analgesics, Opioid; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal | 2016 |
Gabapentin loses efficacy over time after nerve injury in rats: role of glutamate transporter-1 in the locus coeruleus.
Topics: Amines; Analgesics; Animals; Antihypertensive Agents; Atropine; Bronchodilator Agents; Clonidine; CR | 2016 |
Selective Cathepsin S Inhibition with MIV-247 Attenuates Mechanical Allodynia and Enhances the Antiallodynic Effects of Gabapentin and Pregabalin in a Mouse Model of Neuropathic Pain.
Topics: Amines; Animals; Behavior, Animal; Cathepsins; Cyclohexanecarboxylic Acids; Dipeptides; Disease Mode | 2016 |
Brain glutamic acid decarboxylase-67kDa alterations induced by magnesium treatment in olfactory bulbectomy and chronic mild stress models in rats.
Topics: Animals; Antidepressive Agents; Brain; Chronic Disease; Depression; Disease Models, Animal; gamma-Am | 2016 |
Increased anxiety-like behaviour and altered GABAergic system in the amygdala and cerebellum of VPA rats - An animal model of autism.
Topics: Amygdala; Animals; Anxiety; Autism Spectrum Disorder; Cerebellum; Disease Models, Animal; Female; GA | 2016 |
Involvement of glutamatergic N-methyl-d-aspartate receptors in the expression of increased head-dipping behaviors in the hole-board tests of olfactory bulbectomized mice.
Topics: Amygdala; Animals; Anti-Anxiety Agents; Anxiety; Disease Models, Animal; Dizocilpine Maleate; Excita | 2016 |
Sensitivity of the prefrontal GABAergic system to chronic stress in male and female mice: Relevance for sex differences in stress-related disorders.
Topics: Amygdala; Animals; Anxiety; Chronic Disease; Depression; Disease Models, Animal; Female; gamma-Amino | 2016 |
Action potential broadening in a presynaptic channelopathy.
Topics: Action Potentials; Animals; Ataxia; Calcium; Channelopathies; Disease Models, Animal; Elapid Venoms; | 2016 |
FUS-linked essential tremor associated with motor dysfunction in Drosophila.
Topics: Amines; Animals; Animals, Genetically Modified; Cyclohexanecarboxylic Acids; Disease Models, Animal; | 2016 |
Antidepressant-like effects of ascorbic acid and ketamine involve modulation of GABAA and GABAB receptors.
Topics: Animals; Antidepressive Agents; Ascorbic Acid; Depression; Depressive Disorder, Major; Disease Model | 2016 |
Immediate and delayed treatment with gabapentin, carbamazepine and CNQX have almost similar impact on cognitive functions and behavior in the lithium-pilocarpine model in rats.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amines; Animals; Behavior, Animal; Carbamazepine; Cognition; C | 2016 |
Depression-like behavior in rat: Involvement of galanin receptor subtype 1 in the ventral periaqueductal gray.
Topics: Animals; Depression; Disease Models, Animal; gamma-Aminobutyric Acid; Locus Coeruleus; Male; Periaqu | 2016 |
DNA methylation regulates gabrb2 mRNA expression: developmental variations and disruptions in l-methionine-induced zebrafish with schizophrenia-like symptoms.
Topics: Animals; Disease Models, Animal; DNA Methylation; gamma-Aminobutyric Acid; Gene Expression Regulatio | 2016 |
Compromised GABAergic inhibition contributes to tumor-associated epilepsy.
Topics: Animals; Brain; Brain Neoplasms; Bumetanide; Cell Line, Tumor; Disease Models, Animal; Epilepsy; gam | 2016 |
Low dose of L-glutamic acid attenuated the neurological dysfunctions and excitotoxicity in bilateral common carotid artery occluded mice.
Topics: Animals; Brain; Brain Ischemia; Carotid Artery, Common; Disease Models, Animal; Dose-Response Relati | 2016 |
Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target.
Topics: Amines; Amitriptyline; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; Gai | 2016 |
Variant BDNF-Val66Met Polymorphism is Associated with Layer-Specific Alterations in GABAergic Innervation of Pyramidal Neurons, Elevated Anxiety and Reduced Vulnerability of Adolescent Male Mice to Activity-Based Anorexia.
Topics: Animals; Anorexia; Anxiety; Brain-Derived Neurotrophic Factor; CA1 Region, Hippocampal; Dendrites; D | 2017 |
Developmental delay in motor skill acquisition in Niemann-Pick C1 mice reveals abnormal cerebellar morphogenesis.
Topics: Aging; Animals; Animals, Newborn; Cerebellum; Cohort Studies; Developmental Disabilities; Disease Mo | 2016 |
NKCC1 up-regulation contributes to early post-traumatic seizures and increased post-traumatic seizure susceptibility.
Topics: Ammonia; Animals; Animals, Newborn; Bumetanide; Cell Count; Cerebral Cortex; Disease Models, Animal; | 2017 |
In vitro/in vivo evaluation of gamma-aminobutyric acid-loadedN,N-dimethylacrylamide-based pegylated polymeric nanoparticles for brain delivery to treat epilepsy.
Topics: Acrylamides; Animals; Brain; Cells, Cultured; Disease Models, Animal; Drug Delivery Systems; Epileps | 2016 |
The role of IL-1β and glutamate in the effects of lipopolysaccharide on the hippocampal electrical kindling of seizures.
Topics: Analysis of Variance; Animals; Cytokines; Disease Models, Animal; Electric Stimulation; Electroencep | 2016 |
Comparative effects of α2δ-1 ligands in mouse models of colonic hypersensitivity.
Topics: Amines; Animals; Calcium Channels; Cyclohexanecarboxylic Acids; Dextran Sulfate; Disease Models, Ani | 2016 |
Infliximab reduces peripheral inflammation, neuroinflammation, and extracellular GABA in the cerebellum and improves learning and motor coordination in rats with hepatic encephalopathy.
Topics: Animals; Anti-Inflammatory Agents; Cerebellum; Cyclic GMP; Cytokines; Dinoprostone; Disease Models, | 2016 |
Acute spinal cord injury (SCI) transforms how GABA affects nociceptive sensitization.
Topics: Acetates; Analysis of Variance; Animals; Bicuculline; Bumetanide; Capsaicin; Disease Models, Animal; | 2016 |
The Role of Primary Motor Cortex (M1) Glutamate and GABA Signaling in l-DOPA-Induced Dyskinesia in Parkinsonian Rats.
Topics: Animals; Antiparkinson Agents; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, | 2016 |
A rodent model of HIV protease inhibitor indinavir induced peripheral neuropathy.
Topics: Amines; Analgesics; Animals; Calcitonin Gene-Related Peptide; Calcium-Binding Proteins; Cyclohexanec | 2017 |
GABAergic hyperinnervation of dentate granule cells in the Ts65Dn mouse model of down syndrome: Exploring the role of App.
Topics: Aging; Amyloid beta-Protein Precursor; Animals; Cyclin-Dependent Kinase 5; Dentate Gyrus; Disease Mo | 2016 |
Cytosolic Accumulation of L-Proline Disrupts GABA-Ergic Transmission through GAD Blockade.
Topics: Animals; Central Nervous System; Cytosol; Disease Models, Animal; Gamma Rhythm; gamma-Aminobutyric A | 2016 |
Participation of the dentate-rubral pathway in the kindling model of epilepsy.
Topics: Amygdala; Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Glutami | 2017 |
Therapeutic relevance of mTOR inhibition in murine succinate semialdehyde dehydrogenase deficiency (SSADHD), a disorder of GABA metabolism.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Developmental Disabilities; Disease Models, Animal; F | 2017 |
Enzyme activities involved in the glutamate-glutamine cycle are altered to reduce glutamate after spinal cord injury in rats.
Topics: Animals; Chromatography, High Pressure Liquid; Disease Models, Animal; Enzyme Activation; Female; ga | 2016 |
Grafted Neural Precursors Integrate Into Mouse Striatum, Differentiate and Promote Recovery of Function Through Release of Erythropoietin in MPTP-Treated Mice.
Topics: Animals; Antigens; Antigens, Neoplasm; Cell- and Tissue-Based Therapy; Choline O-Acetyltransferase; | 2016 |
Neurotransmitter alteration in a testosterone propionate-induced polycystic ovarian syndrome rat model.
Topics: Animals; Disease Models, Animal; Dopamine; Epinephrine; Female; gamma-Aminobutyric Acid; Glucose Tol | 2017 |
Topical gabapentin gel alleviates allodynia and hyperalgesia in the chronic sciatic nerve constriction injury neuropathic pain model.
Topics: Administration, Topical; Amines; Analgesics; Animals; Constriction, Pathologic; Cyclohexanecarboxyli | 2017 |
Impact of the Chronic Omega-3 Fatty Acids Supplementation in Hemiparkinsonism Model Induced by 6-Hydroxydopamine in Rats.
Topics: Animals; Apomorphine; Biogenic Monoamines; Brain; Dietary Supplements; Disease Models, Animal; Fatty | 2017 |
sec-Butylpropylacetamide (SPD), a new amide derivative of valproic acid for the treatment of neuropathic and inflammatory pain.
Topics: Amides; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin | 2017 |
Artemisinins Target GABA
Topics: Animals; Artemether; Artemisinins; Carrier Proteins; Cell Transdifferentiation; Cells, Cultured; Dia | 2017 |
Dopaminergic treatment weakens medium spiny neuron collateral inhibition in the parkinsonian striatum.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Female; gamma-Amin | 2017 |
A Subpopulation of Dopaminergic Neurons Coexpresses Serotonin in Ventral Mesencephalic Cultures But Not After Intrastriatal Transplantation in a Rat Model of Parkinson's Disease.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cell Count; Cells, Cultured; Disease Models, Animal; Dop | 2017 |
Metabolic injury in a variable rat model of post-status epilepticus.
Topics: Animals; Aspartic Acid; Cluster Analysis; Creatine; Disease Models, Animal; Electroencephalography; | 2016 |
A codon-optimized Mecp2 transgene corrects breathing deficits and improves survival in a mouse model of Rett syndrome.
Topics: Amines; Animals; Apnea; Codon; Cyclohexanecarboxylic Acids; Dependovirus; Disease Models, Animal; Di | 2017 |
Effects of pregabalin on spinal d-serine content and NMDA receptor-mediated synaptic transmission in mice with neuropathic pain.
Topics: Animals; Disease Models, Animal; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Male; | 2017 |
Agomelatine: a new opportunity to reduce neuropathic pain-preclinical evidence.
Topics: Acetamides; Adrenergic alpha-2 Receptor Antagonists; Amines; Animals; Antineoplastic Agents; Constri | 2017 |
Impaired GABAergic inhibition in the hippocampus of Fmr1 knockout mice.
Topics: Animals; CA1 Region, Hippocampal; Disease Models, Animal; Fragile X Mental Retardation Protein; Frag | 2017 |
Influence of Volatile Anesthesia on the Release of Glutamate and other Amino Acids in the Nucleus Accumbens in a Rat Model of Alcohol Withdrawal: A Pilot Study.
Topics: Amino Acids; Anesthesia, Inhalation; Animals; Arginine; Aspartic Acid; Desflurane; Disease Models, A | 2017 |
Carvacrol after status epilepticus (SE) prevents recurrent SE, early seizures, cell death, and cognitive decline.
Topics: Animals; Cell Death; Cognitive Dysfunction; Cymenes; Disease Models, Animal; Electric Stimulation; E | 2017 |
Age-dependent concomitant changes in synaptic dysfunction and GABAergic pathway in the APP/PS1 mouse model.
Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Disease Models, Animal; Dose-Resp | 2016 |
Optogenetic Restoration of Disrupted Slow Oscillations Halts Amyloid Deposition and Restores Calcium Homeostasis in an Animal Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid; Animals; Calcium; Disease Models, Animal; Down-Regulation; gamma-Aminobu | 2017 |
Inhibition Mediated by Glycinergic and GABAergic Receptors on Excitatory Neurons in Mouse Superficial Dorsal Horn Is Location-Specific but Modified by Inflammation.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Freund's Adjuvant; gamma-Aminobutyric Acid; Glyci | 2017 |
Morphological, structural, and functional alterations of the prefrontal cortex and the basolateral amygdala after early lesion of the rat mediodorsal thalamus.
Topics: Animals; Animals, Newborn; Anxiety; Basolateral Nuclear Complex; Behavior, Animal; Cognition; Dendri | 2017 |
7-Fluoro-1,3-diphenylisoquinoline-1-amine reverses the reduction in self-care behavior induced by maternal separation stress in rats by modulating glutamatergic/GABAergic systems.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Disease Models, Animal; Excitatory Ami | 2017 |
Protective Effect of Resveratrol on the Brain in a Rat Model of Epilepsy.
Topics: Animals; Anticonvulsants; CA1 Region, Hippocampal; Disease Models, Animal; Down-Regulation; Epilepsy | 2017 |
GABA and GABA receptors alterations in the primary visual cortex of concave lens-induced myopic model.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Guinea Pigs; Male | 2017 |
Sertraline and venlafaxine improves motor performance and neurobehavioral deficit in quinolinic acid induced Huntington's like symptoms in rats: Possible neurotransmitters modulation.
Topics: Animals; Corpus Striatum; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Huntington | 2017 |
Deficits in the activity of presynaptic γ-aminobutyric acid type B receptors contribute to altered neuronal excitability in fragile X syndrome.
Topics: Aged; Aged, 80 and over; Animals; Behavior, Animal; Disease Models, Animal; Fragile X Mental Retarda | 2017 |
Massively augmented hippocampal dentate granule cell activation accompanies epilepsy development.
Topics: Animals; Chlorides; Dentate Gyrus; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Glutam | 2017 |
An Improved Rodent Model of Trigeminal Neuropathic Pain by Unilateral Chronic Constriction Injury of Distal Infraorbital Nerve.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Functional Lateral | 2017 |
Alterations of Glutamate and γ-Aminobutyric Acid Expressions in Normal and Myopic Eye Development in Guinea Pigs.
Topics: Analysis of Variance; Animals; Axial Length, Eye; Chromatography, High Pressure Liquid; Disease Mode | 2017 |
Immunological alteration & toxic molecular inductions leading to cognitive impairment & neurotoxicity in transgenic mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Cognition D | 2017 |
Parachlorophenylalanine-induced 5-HT depletion alters behavioral and brain neurotransmitters levels in 6-Hz psychomotor seizure model in mice.
Topics: Animals; Brain; Disease Models, Animal; Electroshock; gamma-Aminobutyric Acid; Glutamine; Male; Mice | 2017 |
Sildenafil reduces neuroinflammation in cerebellum, restores GABAergic tone, and improves motor in-coordination in rats with hepatic encephalopathy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Astrocytes; Cerebellum; Disease Models, Animal; GA | 2017 |
Injection of Toll-like receptor 4 siRNA into the ventrolateral periaqueductal gray attenuates withdrawal syndrome in morphine-dependent rats.
Topics: Animals; Blotting, Western; Chromatography, High Pressure Liquid; Disease Models, Animal; Enzyme-Lin | 2016 |
Is there a major role for adenosine A2A receptors in anxiety?
Topics: Adenosine A2 Receptor Antagonists; Adrenocorticotropic Hormone; Animals; Anti-Anxiety Agents; Anxiet | 2008 |
Cellular and behavioral interactions of gabapentin with alcohol dependence.
Topics: Alcoholism; Amines; Amygdala; Animals; Behavior, Animal; Central Nervous System Depressants; Cyclohe | 2008 |
Chandelier cartridges in the prefrontal cortex are reduced in isolation reared rats.
Topics: Animals; Axons; Behavior, Animal; Cell Differentiation; Disease Models, Animal; Environment, Control | 2008 |
Plasticity of lumbosacral propriospinal neurons is associated with the development of autonomic dysreflexia after thoracic spinal cord transection.
Topics: Afferent Pathways; Animals; Antibodies; Autonomic Dysreflexia; Biotin; Choline O-Acetyltransferase; | 2008 |
Circadian distribution of generalized tonic-clonic seizures associated with murine succinic semialdehyde dehydrogenase deficiency, a disorder of GABA metabolism.
Topics: Age Factors; Animals; Brain; Circadian Rhythm; Disease Models, Animal; Epilepsy, Tonic-Clonic; gamma | 2008 |
Prolonged nociceptive responses to hind paw formalin injection in rats with a spinal cord injury.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Fixatives; Formaldehyde; Functional Laterality; g | 2008 |
Brief post-stressor treatment with pregabalin in an animal model for PTSD: short-term anxiolytic effects without long-term anxiogenic effect.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Anticonvulsants; Anxiety; Behavior, Animal; Cue | 2008 |
Effects of hyperhomocysteinemia on non-adrenergic non-cholinergic relaxation in isolated rat duodenum.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Disease Models, Animal; Duodenum; Electric Stimulati | 2008 |
GABAergic mechanism mediated via D receptors in the rat periaqueductal gray participates in the micturition reflex: an in vivo microdialysis study.
Topics: Animals; Benzazepines; Denervation; Disease Models, Animal; Dopamine; Dopamine Antagonists; Extracel | 2008 |
Antiepileptic drug resistant rats differ from drug responsive rats in GABA A receptor subunit expression in a model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Dentate Gyrus; Disease Models, Animal; Drug Resistance; Electric Stimulati | 2008 |
Anxiety-like behaviour in rats with mononeuropathy is reduced by the analgesic drugs morphine and gabapentin.
Topics: Amines; Analgesics; Animals; Anxiety; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapenti | 2008 |
Endonuclease G expression in thalamic reticular nucleus after global cerebral ischemia.
Topics: Active Transport, Cell Nucleus; Animals; Apoptosis; Astrocytes; Biomarkers; Brain Infarction; Brain | 2008 |
Moderate perinatal arsenic exposure alters neuroendocrine markers associated with depression and increases depressive-like behaviors in adult mouse offspring.
Topics: Analysis of Variance; Animals; Animals, Newborn; Arsenic; Behavior, Animal; Corticosterone; Depressi | 2008 |
Effects of pregabalin on visceral pain responses and colonic compliance in rats.
Topics: Abdominal Pain; Administration, Oral; Analgesics; Animals; Blood Pressure; Calcium Channels; Colon; | 2008 |
Antinociceptive action of GLYX-13: an N-methyl-D-aspartate receptor glycine site partial agonist.
Topics: Amines; Analgesics; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Disease Models, Animal; | 2008 |
6-OHDA-induced hemiparkinsonism and chronic L-DOPA treatment increase dopamine D1-stimulated [(3)H]-GABA release and [(3)H]-cAMP production in substantia nigra pars reticulata of the rat.
Topics: 1-Methyl-3-isobutylxanthine; Analysis of Variance; Animals; Antiparkinson Agents; Behavior, Animal; | 2008 |
The effects of adenosine A2A receptor antagonists on haloperidol-induced movement disorders in primates.
Topics: Adenosine A2 Receptor Antagonists; Animals; Antipsychotic Agents; Caffeine; Catalepsy; Cebus; Corpus | 2008 |
Comparative antiallodynic activity of morphine, pregabalin and lidocaine in a rat model of neuropathic pain produced by one oxaliplatin injection.
Topics: Analgesics; Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response R | 2008 |
Intra-periaqueductal gray matter injections of midazolam fail to alter anxiety in plus-maze experienced mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Anxiety Disorders; Avoidance Learning; Disease Models, Animal | 2008 |
Neuroactive steroids and GABAA receptor plasticity in the brain of the WAG/Rij rat, a model of absence epilepsy.
Topics: Aging; Animals; Animals, Genetically Modified; Brain; Brain Chemistry; Cerebral Cortex; Desoxycortic | 2008 |
Benefits and risks of intranigral transplantation of GABA-producing cells subsequent to the establishment of kindling-induced seizures.
Topics: Animals; Brain Tissue Transplantation; Cell Line, Transformed; Disease Models, Animal; Epilepsy; Fem | 2008 |
Mice lacking the schizophrenia-associated protein FEZ1 manifest hyperactivity and enhanced responsiveness to psychostimulants.
Topics: Animals; Base Sequence; Brain; Central Nervous System Stimulants; Disease Models, Animal; Dizocilpin | 2008 |
Tactile allodynia can occur in the spared nerve injury model in the rat without selective loss of GABA or GABA(A) receptors from synapses in laminae I-II of the ipsilateral spinal dorsal horn.
Topics: Animals; Denervation; Disease Models, Animal; Functional Laterality; gamma-Aminobutyric Acid; Hypera | 2008 |
Differential involvement of GABA system in mediating behavioral and neurochemical effect of acupuncture in ethanol-withdrawn rats.
Topics: Acupuncture; Acupuncture Points; Analysis of Variance; Animals; Behavior, Animal; Bicuculline; Brain | 2008 |
Time-course of neuronal death in the mouse pilocarpine model of chronic epilepsy using Fluoro-Jade C staining.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Brain; Cerebral Cortex; Chronic Disease; Convulsa | 2008 |
Isobolographic and behavioral characterizations of interactions between vigabatrin and gabapentin in two experimental models of epilepsy.
Topics: Amines; Animals; Anticonvulsants; Behavior, Animal; Brain; Cyclohexanecarboxylic Acids; Disease Mode | 2008 |
Downregulation of tonic GABAergic inhibition in a mouse model of fragile X syndrome.
Topics: Animals; Disease Models, Animal; Down-Regulation; Fragile X Mental Retardation Protein; Fragile X Sy | 2009 |
Behavioral recovery in MPTP-treated monkeys: neurochemical mechanisms studied by intrastriatal microdialysis.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Chlorocebus aethiops; Corpus Striatum; Di | 2008 |
Developmental impact of a familial GABAA receptor epilepsy mutation.
Topics: Animals; Brain; Brain Chemistry; Convulsants; Disease Models, Animal; Epilepsy; gamma-Aminobutyric A | 2008 |
Modulation of gamma-aminobutyric acid on painful sense in central nervous system of morphine-dependent rats.
Topics: Action Potentials; Animals; Bicuculline; Disease Models, Animal; Drug Administration Schedule; Elect | 2008 |
Neonatal neuronal circuitry shows hyperexcitable disturbance in a mouse model of the adult-onset neurodegenerative disease amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Animals, Newborn; Brain Stem; Disease Models, Animal; Dose-R | 2008 |
Acid sensing ion channel (ASIC) inhibitors exhibit anxiolytic-like activity in preclinical pharmacological models.
Topics: Acid Sensing Ion Channels; Amiloride; Amygdala; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Ani | 2009 |
The evaluation of effect of alpha-lipoic acid and vitamin E on the lipid peroxidation, gamma-amino butyric acid and serotonin level in the brain of mice (Mus musculus) acutely intoxicated with lindane.
Topics: Animals; Brain; Disease Models, Animal; gamma-Aminobutyric Acid; Hexachlorocyclohexane; Insecticides | 2009 |
GAB(A) receptors present higher affinity and modified subunit composition in spinal motor neurons from a genetic model of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Cell Death; Cells, Cultured; Chloride Channels; Disease Mode | 2008 |
Uncoupling of neurodegeneration and gliosis in a murine model of juvenile cortical lesion.
Topics: Animals; Astrocytes; Atrophy; Brain; Brain Injuries; Cold Temperature; Cyclic Nucleotide Phosphodies | 2009 |
Prolonged gabapentin analgesia in an experimental mouse model of fibromyalgia.
Topics: Amines; Analgesia; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Drug Ad | 2008 |
Effects of distal nerve injuries on dorsal-horn neurons and glia: relationships between lesion size and mechanical hyperalgesia.
Topics: Animals; Axotomy; Disease Models, Animal; Functional Laterality; gamma-Aminobutyric Acid; Glial Fibr | 2009 |
Protein kinase Cdelta regulates ethanol intoxication and enhancement of GABA-stimulated tonic current.
Topics: Alcohol-Induced Disorders, Nervous System; Animals; Benzodiazepines; Brain; Cells, Cultured; Central | 2008 |
GABA is not elevated during neuroprotective neuronal depression in the hypoxic epaulette shark (Hemiscyllium ocellatum).
Topics: Acclimatization; Animals; Brain; Chromatography, High Pressure Liquid; Disease Models, Animal; gamma | 2009 |
The novel nociceptin/orphanin FQ receptor antagonist Trap-101 alleviates experimental parkinsonism through inhibition of the nigro-thalamic pathway: positive interaction with L-DOPA.
Topics: Animals; Antiparkinson Agents; Benzimidazoles; Disease Models, Animal; Dose-Response Relationship, D | 2008 |
The role of GABA and anxiety in the reconsolidation of conditioned fear.
Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Bicuculline; Conditioning, Psychological; | 2008 |
Reinstated ethanol-seeking in rats is modulated by environmental context and requires the nucleus accumbens core.
Topics: Alcohol-Induced Disorders, Nervous System; Animals; Central Nervous System Depressants; Conditioning | 2008 |
An insight on the neuropharmacological activity of Telescopium telescopium--a mollusc from the Sunderban mangrove.
Topics: Animals; Behavior, Animal; Body Temperature; Brain; Central Nervous System Depressants; Disease Mode | 2008 |
Novel role of CXCR2 in regulation of gamma-secretase activity.
Topics: Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Cells, Cultured; Chem | 2008 |
Expression of the GABAergic system in animal models for fragile X syndrome and fragile X associated tremor/ataxia syndrome (FXTAS).
Topics: Analysis of Variance; Animals; Biological Evolution; Cerebellum; Cerebral Cortex; Disease Models, An | 2009 |
Interleukin-6 mediates the increase in NADPH-oxidase in the ketamine model of schizophrenia.
Topics: Animals; Antibodies; Cells, Cultured; Disease Models, Animal; Enzyme Activation; gamma-Aminobutyric | 2008 |
Interleukin-6 mediates the increase in NADPH-oxidase in the ketamine model of schizophrenia.
Topics: Animals; Antibodies; Cells, Cultured; Disease Models, Animal; Enzyme Activation; gamma-Aminobutyric | 2008 |
Interleukin-6 mediates the increase in NADPH-oxidase in the ketamine model of schizophrenia.
Topics: Animals; Antibodies; Cells, Cultured; Disease Models, Animal; Enzyme Activation; gamma-Aminobutyric | 2008 |
Interleukin-6 mediates the increase in NADPH-oxidase in the ketamine model of schizophrenia.
Topics: Animals; Antibodies; Cells, Cultured; Disease Models, Animal; Enzyme Activation; gamma-Aminobutyric | 2008 |
Interleukin-6 mediates the increase in NADPH-oxidase in the ketamine model of schizophrenia.
Topics: Animals; Antibodies; Cells, Cultured; Disease Models, Animal; Enzyme Activation; gamma-Aminobutyric | 2008 |
Interleukin-6 mediates the increase in NADPH-oxidase in the ketamine model of schizophrenia.
Topics: Animals; Antibodies; Cells, Cultured; Disease Models, Animal; Enzyme Activation; gamma-Aminobutyric | 2008 |
Interleukin-6 mediates the increase in NADPH-oxidase in the ketamine model of schizophrenia.
Topics: Animals; Antibodies; Cells, Cultured; Disease Models, Animal; Enzyme Activation; gamma-Aminobutyric | 2008 |
Interleukin-6 mediates the increase in NADPH-oxidase in the ketamine model of schizophrenia.
Topics: Animals; Antibodies; Cells, Cultured; Disease Models, Animal; Enzyme Activation; gamma-Aminobutyric | 2008 |
Interleukin-6 mediates the increase in NADPH-oxidase in the ketamine model of schizophrenia.
Topics: Animals; Antibodies; Cells, Cultured; Disease Models, Animal; Enzyme Activation; gamma-Aminobutyric | 2008 |
Stimulation of delta opioid receptors located in substantia nigra reticulata but not globus pallidus or striatum restores motor activity in 6-hydroxydopamine lesioned rats: new insights into the role of delta receptors in parkinsonism.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzamides; Bicuculline; Bridged Bicyclo Compounds, | 2008 |
Hyperactive interneurons impair learning in a neurofibromatosis model.
Topics: Animals; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; gamma-Aminobutyric Acid | 2009 |
Abnormal network activity in a targeted genetic model of human double cortex.
Topics: Analysis of Variance; Animals; Animals, Genetically Modified; Animals, Newborn; Bicuculline; Cerebra | 2009 |
Metabonomic characterization of the 3-nitropropionic acid rat model of Huntington's disease.
Topics: Animals; Behavior, Animal; Brain; Brain Stem; Cerebellum; Cerebral Cortex; Choline; Corpus Striatum; | 2009 |
Neural basis of psychosis-related behaviour in the infection model of schizophrenia.
Topics: Animals; Avoidance Learning; Brain; Disease Models, Animal; Dopamine; Female; gamma-Aminobutyric Aci | 2009 |
Enhancement of inhibitory synaptic transmission in large aspiny neurons after transient cerebral ischemia.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Biophysics; | 2009 |
Pharmacodynamic and pharmacokinetic interaction profiles of levetiracetam in combination with gabapentin, tiagabine and vigabatrin in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis.
Topics: Amines; Animals; Anticonvulsants; Brain; Cyclohexanecarboxylic Acids; Disease Models, Animal; Drug I | 2009 |
Impaired striatal D2 receptor function leads to enhanced GABA transmission in a mouse model of DYT1 dystonia.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Dystonic Disorders; Excitatory Postsynaptic P | 2009 |
Participation of GABA-ergic system in epileptogenic activity induced by teicoplanin in mice.
Topics: Animals; Anti-Bacterial Agents; Bicuculline; Brain; Disease Models, Animal; Dizocilpine Maleate; Ele | 2009 |
Oral pregabalin reverses cold allodynia in two distinct models of peripheral neuropathic pain.
Topics: Administration, Oral; Analgesics; Animals; Behavior, Animal; Chronic Disease; Cold Temperature; Dise | 2009 |
[Effects of Semen Ziziphi Spinosae on the anxiety behavior of the yin deficiency mice].
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Brain; Diazepam; Disease Models, Animal; Dr | 2008 |
The role of cholinergic and GABAergic medial septal/diagonal band cell populations in the emergence of diencephalic amnesia.
Topics: Acetylcholine; Amnesia; Animals; Brain; Calbindins; Cell Death; Choline O-Acetyltransferase; Disease | 2009 |
Protective effects of gabapentin on allodynia and alpha 2 delta 1-subunit of voltage-dependent calcium channel in spinal nerve-ligated rats.
Topics: Amines; Analgesics; Animals; Calcium Channels; Calcium Channels, L-Type; Cyclohexanecarboxylic Acids | 2009 |
Effect of gabapentin on cognitive processes in rats not exposed and exposed to tobacco smoke during fetal life.
Topics: Amines; Animals; Anticonvulsants; Antidepressive Agents; Behavior, Animal; Cognition; Cyclohexanecar | 2008 |
Pre-ischemic treadmill training affects glutamate and gamma aminobutyric acid levels in the striatal dialysate of a rat model of cerebral ischemia.
Topics: Animals; Brain Ischemia; Corpus Striatum; Disease Models, Animal; Exercise Test; gamma-Aminobutyric | 2009 |
Intrathecal gabapentin does not act as a hyperpolarization-activated cyclic nucleotide-gated channel activator in the rat formalin test.
Topics: Amines; Analgesics; Animals; Cardiotonic Agents; Cyclic Nucleotide-Gated Cation Channels; Cyclohexan | 2009 |
Transient oligemia is associated with long-term changes in binding densities of cortical inhibitory GABAA receptors in the rat brain.
Topics: Animals; Binding, Competitive; Cerebral Cortex; Disease Models, Animal; Down-Regulation; GABA Agonis | 2009 |
The increased trafficking of the calcium channel subunit alpha2delta-1 to presynaptic terminals in neuropathic pain is inhibited by the alpha2delta ligand pregabalin.
Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Calcium Channels; Calcium Channels | 2009 |
Changes in GABA(A) receptor subunit gamma 2 in extensor and flexor motoneurons and astrocytes after spinal cord transection and motor training.
Topics: Animals; Astrocytes; Disease Models, Animal; Exercise Therapy; Female; Fluorescent Dyes; gamma-Amino | 2009 |
Blood serum profiling of the rat spinal nerve ligation model using ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry.
Topics: Amines; Analgesics; Animals; Biomarkers; Chromatography, High Pressure Liquid; Cyclohexanecarboxylic | 2009 |
Chronic dietary administration of valproic acid protects neurons of the rat nucleus basalis magnocellularis from ibotenic acid neurotoxicity.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Basal Nucleus of Meynert; Cerebral Cortex; Choline O-A | 2009 |
Increased vulnerability to depressive-like behavior of mice with decreased expression of VGLUT1.
Topics: Analysis of Variance; Animals; Brain; Brain Chemistry; Carbon Isotopes; Depression; Disease Models, | 2009 |
Antinociceptive effects of chronic administration of uncompetitive NMDA receptor antagonists in a rat model of diabetic neuropathic pain.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Cyclopentanes; Diabetes Mellitus, Experime | 2009 |
Abnormal sensitivity of cannabinoid CB1 receptors in the striatum of mice with experimental amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Corpus Striatum; Disease Models, Animal; Dronabinol; Excitat | 2010 |
The effects of group III mGluR ligands on pentylenetetrazol-induced kindling of seizures and hippocampal amino acids concentration.
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Convulsants; Disease Models, Animal; Dose-Response Re | 2009 |
In vivo effects of activation and blockade of 5-HT(2A/2C) receptors in the firing activity of pyramidal neurons of medial prefrontal cortex in a rodent model of Parkinson's disease.
Topics: Action Potentials; Amphetamines; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; | 2009 |
Inhibitory inputs to hippocampal interneurons are reorganized in Lis1 mutant mice.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Action Potentials; Animals; Calbindin 2; Classical L | 2009 |
A rodent model of schizophrenia derived from postmortem studies.
Topics: Amygdala; Animals; Disease Models, Animal; Electrophysiology; GABA Antagonists; gamma-Aminobutyric A | 2009 |
Protein ubiquitination in postsynaptic densities after hypoxia in rat neostriatum is blocked by hypothermia.
Topics: Analysis of Variance; Animals; Animals, Newborn; Calbindins; Disease Models, Animal; Electron Micros | 2009 |
Continuous bilateral infusion of GABA in the dorsomedian nucleus of the thalamus elevates the generalized seizure threshold in amygdala-kindled rats.
Topics: Amygdala; Animals; Disease Models, Animal; Electric Stimulation; Epilepsy, Generalized; Functional L | 2009 |
Release of [3H]D-aspartate induced by K+-stimulation is increased in the cervical spinal cord of the wobbler mouse: a model of motor neuron disease.
Topics: Animals; Aspartic Acid; Cervical Vertebrae; Disease Models, Animal; gamma-Aminobutyric Acid; Mice; M | 2009 |
Transcriptome profiling reveals TGF-beta signaling involvement in epileptogenesis.
Topics: Action Potentials; Albumins; Animals; Antibodies; Astrocytes; Benzamides; Blood-Brain Barrier; Brain | 2009 |
Antinociceptive effects of NCX-701 (nitro-paracetamol) in neuropathic rats: enhancement of antinociception by co-administration with gabapentin.
Topics: Acetaminophen; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dos | 2009 |
Schizophrenia-like GABAergic gene expression deficits in cerebellar Golgi cells from rats chronically exposed to low-dose phencyclidine.
Topics: Action Potentials; Animals; Cerebellum; Disease Models, Animal; Dose-Response Relationship, Drug; Dr | 2009 |
Descending serotonergic facilitation and the antinociceptive effects of pregabalin in a rat model of osteoarthritic pain.
Topics: Analgesics; Animals; Behavior, Animal; Calcium Channels; Calcium Channels, L-Type; Disease Models, A | 2009 |
Electroconvulsive stimulation (ECS) increases the expression of neuropeptide Y (NPY) in rat brains in a model of neuropathic pain: a quantitative real-time polymerase chain reaction (RT-PCR) study.
Topics: Animals; Brain; Brain Chemistry; Disease Models, Animal; Electroconvulsive Therapy; gamma-Aminobutyr | 2009 |
Optical suppression of experimental seizures in rat brain slices.
Topics: 4-Aminopyridine; Animals; Convulsants; Disease Models, Animal; Epilepsies, Partial; GABA Agents; gam | 2010 |
Regionalized loss of parvalbumin interneurons in the cerebral cortex of mice with deficits in GFRalpha1 signaling.
Topics: Action Potentials; Age Factors; Animals; Animals, Newborn; Brain Mapping; Caspase 3; Cell Death; Cer | 2009 |
Alterations in extracellular levels of gamma-aminobutyric acid in the rat basolateral amygdala and periaqueductal gray during conditioned fear, persistent pain and fear-conditioned analgesia.
Topics: Amygdala; Animals; Behavior, Animal; Conditioning, Psychological; Disease Models, Animal; Electric S | 2009 |
Gabapentin treatment improves motor coordination in a mice model of progressive ataxia.
Topics: Age Factors; Amines; Analysis of Variance; Animals; Ataxia; Atrophy; Cell Count; Cerebellum; Chromat | 2009 |
Pattern of injury with a graded excitotoxic insult and ensuing chronic medial septal damage in the rat brain.
Topics: Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Atroph | 2009 |
Subdiaphragmatic vagotomy promotes nociceptive sensitivity of deep tissue in rats.
Topics: Amines; Amitriptyline; Analgesics, Opioid; Animals; Cyclohexanecarboxylic Acids; Diaphragm; Disease | 2009 |
Matrix metalloproteinase-3 contributes to vulnerability of the nigral dopaminergic neurons.
Topics: Animals; Cell Count; Cells, Cultured; Corpus Striatum; Cytoprotection; Dendrites; Disease Models, An | 2010 |
Calcium binding proteins immunoreactivity in the rat basolateral amygdala following myocardial infarction.
Topics: Amygdala; Animals; Biomarkers; Brain Mapping; Calbindin 2; Calbindins; Calcium-Binding Proteins; Dep | 2010 |
Synthesis of N4-(2,4-dimethylphenyl) semicarbazones as 4-aminobutyrate aminotransferase inhibitors.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Behavior, Animal; Brain; Disease Models, Ani | 2006 |
Intrastrain differences in seizure susceptibility, pharmacological response and basal neurochemistry of Wistar rats.
Topics: Analysis of Variance; Anesthetics, Dissociative; Animals; Biogenic Monoamines; Body Weight; Brain; B | 2009 |
GABA and valproate modulate trigeminovascular nociceptive transmission in the thalamus.
Topics: Amines; Animals; Anticonvulsants; Cerebral Arteries; Cyclohexanecarboxylic Acids; Disease Models, An | 2010 |
T-type calcium channel inhibition underlies the analgesic effects of the endogenous lipoamino acids.
Topics: Analgesics; Animals; Arachidonic Acids; Behavior, Animal; Calcium; Calcium Channel Blockers; Calcium | 2009 |
Antiepileptic drugs combined with high-frequency electrical stimulation in the ventral hippocampus modify pilocarpine-induced status epilepticus in rats.
Topics: Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Disease Models, Animal; Electric Stim | 2010 |
Postnatal exposure to MK801 induces selective changes in GAD67 or parvalbumin.
Topics: Aging; Animals; Animals, Newborn; Cell Count; Cell Differentiation; Disease Models, Animal; Dizocilp | 2010 |
Synthesis and in vivo evaluation of 3,4-disubstituted gababutins.
Topics: Amines; Amino Acids; Animals; Anti-Anxiety Agents; Cyclohexanecarboxylic Acids; Cyclopentanes; Disea | 2010 |
Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes.
Topics: Action Potentials; Analysis of Variance; Animals; Animals, Newborn; Cerebral Cortex; Disease Models, | 2010 |
Flumazenil administration attenuates cognitive impairment in immature rats after controlled cortical impact.
Topics: Animals; Brain; Brain Chemistry; Brain Injuries; Cognition Disorders; Disease Models, Animal; Dose-R | 2010 |
Reduction of seizures by transplantation of embryonic GABAergic interneurons into Kv1.1 mutant mice.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Interneurons; Kv1.1 Potassium Channel; Mic | 2009 |
Impact of ethanol on the developing GABAergic system.
Topics: Alcohol-Induced Disorders, Nervous System; Animals; Cell Movement; Cell Proliferation; Central Nervo | 2009 |
Motor activity-induced dopamine release in the substantia nigra is regulated by muscarinic receptors.
Topics: Analysis of Variance; Animals; Area Under Curve; Brain Injuries; Chromatography, High Pressure Liqui | 2010 |
Replacement with GABAergic steroid precursors restores the acute ethanol withdrawal profile in adrenalectomy/gonadectomy mice.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Acute Disease; Alcohol-Induced | 2010 |
Kindling as a model of temporal lobe epilepsy induces bilateral changes in spontaneous striatal activity.
Topics: Action Potentials; Amygdala; Animals; Corpus Striatum; Disease Models, Animal; Epilepsy, Temporal Lo | 2010 |
Endogenous nociceptin/orphanin FQ (N/OFQ) contributes to haloperidol-induced changes of nigral amino acid transmission and parkinsonism: a combined microdialysis and behavioral study in naïve and nociceptin/orphanin FQ receptor knockout mice.
Topics: Animals; Antipsychotic Agents; Benzimidazoles; Disease Models, Animal; Dose-Response Relationship, D | 2010 |
Pilocarpine-induced status epilepticus causes acute interneuron loss and hyper-excitatory propagation in rat insular cortex.
Topics: Animals; Biomarkers; Cell Count; Cerebral Cortex; Convulsants; Disease Models, Animal; Electric Stim | 2010 |
Neuroprotective effects of resveratrol on ischemic injury mediated by modulating the release of neurotransmitter and neuromodulator in rats.
Topics: Animals; Antioxidants; Brain; Brain Infarction; Disease Models, Animal; Ethanolamines; Excitatory Po | 2010 |
Altered balance of gamma-aminobutyric acidergic and glutamatergic afferent inputs in rostral ventrolateral medulla-projecting neurons in the paraventricular nucleus of the hypothalamus of renovascular hypertensive rats.
Topics: Animals; Biomarkers; Cardiovascular System; Dendrites; Disease Models, Animal; Excitatory Postsynapt | 2010 |
Initial loss but later excess of GABAergic synapses with dentate granule cells in a rat model of temporal lobe epilepsy.
Topics: Animals; Cell Count; Convulsants; Dendritic Spines; Dentate Gyrus; Disease Models, Animal; Epilepsy, | 2010 |
Monosodium glutamate neonatal treatment as a seizure and excitotoxic model.
Topics: Amino Acids; Animals; Animals, Newborn; Biosensing Techniques; Cerebral Ventricles; Disease Models, | 2010 |
Antihypertensive effect of a gamma-aminobutyric acid rich tomato cultivar 'DG03-9' in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Disease Models, Animal; gamma-Aminobutyric Acid; H | 2010 |
Age- and dose-specific anticonvulsant action of bumetanide in immature rats.
Topics: Age Factors; Aging; Animals; Anticonvulsants; Bumetanide; Disease Models, Animal; Dose-Response Rela | 2009 |
Loss of GABAergic interneurons in laminae I-III of the spinal cord dorsal horn contributes to reduced GABAergic tone and neuropathic pain after spinal cord injury.
Topics: Animals; Apoptosis; Caspase 3; Cell Count; Disease Models, Animal; Down-Regulation; GABA Agonists; G | 2010 |
Methionine sulfoximine, an inhibitor of glutamine synthetase, lowers brain glutamine and glutamate in a mouse model of ALS.
Topics: Amyotrophic Lateral Sclerosis; Animals; Biomarkers; Corpus Striatum; Disease Models, Animal; Down-Re | 2010 |
Novel long-term anticonvulsant treatment with gabapentin without causing memory impairment in mice.
Topics: Amines; Animals; Anticonvulsants; Cognition Disorders; Cyclohexanecarboxylic Acids; Disease Models, | 2010 |
Hippocampal GABAergic dysfunction in a rat chronic mild stress model of depression.
Topics: Action Potentials; Animals; Antidepressive Agents, Second-Generation; Citalopram; Dentate Gyrus; Dep | 2011 |
Treatments for neuropathic pain differentially affect delayed matching accuracy by macaques: effects of amitriptyline and gabapentin.
Topics: Amines; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Animals; Cyclohexanecarboxylic Acids; D | 2010 |
Interactions of 1-methyl-1,2,3,4-tetrahydroisoquinoline with lamotrigine, oxcarbazepine, pregabalin, and topiramate in the mouse maximal electroshock-induced seizure model: a type I isobolographic analysis.
Topics: Animals; Anticonvulsants; Avoidance Learning; Carbamazepine; Disease Models, Animal; Dopamine Antago | 2010 |
Changes in central sodium and not osmolarity or lactate induce panic-like responses in a model of panic disorder.
Topics: Action Potentials; Animals; Cardiovascular Physiological Phenomena; Disease Models, Animal; Dorsomed | 2010 |
Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate.
Topics: Analgesics; Animals; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response Rel | 2010 |
In vitro activation of GAT1 transporters expressed in spinal cord gliosomes stimulates glutamate release that is abnormally elevated in the SOD1/G93A(+) mouse model of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Calcium; Chelating Agents; Disease Models, Animal; Dose-Resp | 2010 |
Transgene-mediated GDNF expression enhances synaptic connectivity and GABA transmission to improve functional outcome after spinal cord contusion.
Topics: Analysis of Variance; Animals; Cells, Cultured; Disease Models, Animal; Embryo, Mammalian; Female; g | 2010 |
A novel CC-chemokine receptor 3 antagonist, Ki19003, inhibits airway eosinophilia and subepithelial/peribronchial fibrosis induced by repeated antigen challenge in mice.
Topics: Airway Remodeling; Animals; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Dose-Respo | 2010 |
Spinal GABA receptors mediate the suppressive effect of electroacupuncture on cold allodynia in rats.
Topics: Animals; Cold Temperature; Denervation; Disease Models, Animal; Electroacupuncture; GABA Antagonists | 2010 |
Transplant of GABAergic precursors restores hippocampal inhibitory function in a mouse model of seizure susceptibility.
Topics: Animals; Disease Models, Animal; Fluorescent Antibody Technique; gamma-Aminobutyric Acid; Hippocampu | 2010 |
Changes in firing rate and pattern of GABAergic neurons in subregions of the substantia nigra pars reticulata in rat models of Parkinson's disease.
Topics: Action Potentials; Animals; Cell Count; Disease Models, Animal; gamma-Aminobutyric Acid; Male; Media | 2010 |
Behavioral deficit and decreased GABA receptor functional regulation in the cerebellum of epileptic rats: effect of Bacopa monnieri and bacoside A.
Topics: Animals; Anticonvulsants; Behavioral Symptoms; Bicuculline; Carbamazepine; Cerebellum; Disease Model | 2010 |
Chemical composition and evaluation of the anti-hypernociceptive effect of the essential oil extracted from the leaves of Ugni myricoides on inflammatory and neuropathic models of pain in mice.
Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Bicyclic Monoterpenes; Carr | 2010 |
Does age matter? Behavioral and neuro-anatomical effects of neonatal and adult basal forebrain cholinergic lesions.
Topics: Acetylcholine; Age Factors; Aging; Analysis of Variance; Animals; Animals, Newborn; Antibodies, Mono | 2010 |
Defects of synaptic vesicle turnover at excitatory and inhibitory synapses in Niemann-Pick C1-deficient neurons.
Topics: Animals; Brain; Dendritic Spines; Disease Models, Animal; Excitatory Postsynaptic Potentials; Exocyt | 2010 |
Seizure suppression in amygdala-kindled mice by transplantation of neural stem/progenitor cells derived from mouse embryonic stem cells.
Topics: Amygdala; Animals; Cell Culture Techniques; Cell Differentiation; Cell Lineage; Cells, Cultured; Cul | 2010 |
Nicotine self-administration differentially modulates glutamate and GABA transmission in hypothalamic paraventricular nucleus to enhance the hypothalamic-pituitary-adrenal response to stress.
Topics: Adrenocorticotropic Hormone; Animals; Corticosterone; Disease Models, Animal; Electric Stimulation; | 2010 |
micro-Opioid receptor endocytosis prevents adaptations in ventral tegmental area GABA transmission induced during naloxone-precipitated morphine withdrawal.
Topics: Adaptation, Physiological; Animals; Chimera; Cyclic AMP; Disease Models, Animal; Endocytosis; gamma- | 2010 |
Differential plasticity of the GABAergic and glycinergic synaptic transmission to rat lumbar motoneurons after spinal cord injury.
Topics: Animals; Animals, Newborn; Brain Stem; Disease Models, Animal; Down-Regulation; Efferent Pathways; g | 2010 |
Diabetic thermal hyperalgesia: role of TRPV1 and CB1 receptors of periaqueductal gray.
Topics: Analgesia; Analgesics; Animals; Benzoxazines; Capsaicin; Diabetes Mellitus, Experimental; Diabetic N | 2010 |
Comparative anticonvulsant activities of the essential oils (EOs) from Cymbopogon winterianus Jowitt and Cymbopogon citratus (DC) Stapf. in mice.
Topics: Animals; Anticonvulsants; Brazil; Cymbopogon; Disease Models, Animal; Dose-Response Relationship, Dr | 2010 |
Selective reductions in subpopulations of GABAergic neurons in a developmental rat model of epilepsy.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy; Female; gamma-Aminobutyric Acid; Glutamate Decarbo | 2010 |
N-methyl-D-aspartate, hyperpolarization-activated cation current (Ih) and gamma-aminobutyric acid conductances govern the risk of epileptogenesis following febrile seizures in rat hippocampus.
Topics: Animals; Animals, Newborn; Bicuculline; Biophysics; Cyclic Nucleotide-Gated Cation Channels; Disease | 2010 |
Midkine, heparin-binding growth factor, blocks kainic acid-induced seizure and neuronal cell death in mouse hippocampus.
Topics: Animals; Anticonvulsants; Astrocytes; Biomarkers; Cell Death; Cytokines; Disease Models, Animal; Epi | 2010 |
Magnesium supplementation enhances the anticonvulsant potential of valproate in pentylenetetrazol-treated rats.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Drug Synergism; gamma-Aminobutyric Acid; Gl | 2010 |
Effect of gene dosage on single-cell hippocampal electrophysiology in a murine model of SSADH deficiency (gamma-hydroxybutyric aciduria).
Topics: Animals; Animals, Newborn; Biophysics; Disease Models, Animal; Dose-Response Relationship, Drug; Ele | 2010 |
Electro-acupuncture stimulation acts on the basal ganglia output pathway to ameliorate motor impairment in Parkinsonian model rats.
Topics: Acupuncture Therapy; Animals; Basal Ganglia; Corpus Striatum; Disease Models, Animal; Dopamine; Elec | 2010 |
Interaction of pregabalin with carbamazepine in the mouse maximal electroshock-induced seizure model: a type I isobolographic analysis for non-parallel dose-response relationship curves.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Drug Interactions; Electroshock; ga | 2010 |
Exogenous brain-derived neurotrophic factor rescues synaptic dysfunction in Mecp2-null mice.
Topics: Action Potentials; Animals; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Evoked Potent | 2010 |
Cognitive impairment in pain through amygdala-driven prefrontal cortical deactivation.
Topics: Amygdala; Animals; Arthritis; Cognition Disorders; Decision Making; Disease Models, Animal; gamma-Am | 2010 |
Lateral paracapsular GABAergic synapses in the basolateral amygdala contribute to the anxiolytic effects of beta 3 adrenoceptor activation.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepro | 2010 |
Analgesic effects of gabapentin on mechanical hypersensitivity in a rat model of chronic pancreatitis.
Topics: Amines; Analgesics; Animals; Calcium Channels; Calcium Channels, L-Type; Cyclohexanecarboxylic Acids | 2010 |
Effect of analgesic standards on persistent postoperative pain evoked by skin/muscle incision and retraction (SMIR).
Topics: Amines; Analgesics; Animals; Chronic Disease; Cyclohexanecarboxylic Acids; Dermatologic Surgical Pro | 2010 |
Neuronal damage in the preterm baboon: impact of the mode of ventilatory support.
Topics: Animals; Calbindin 2; Cell Count; Continuous Positive Airway Pressure; Disease Models, Animal; Femal | 2010 |
Tissue-specific variation of Ube3a protein expression in rodents and in a mouse model of Angelman syndrome.
Topics: Analysis of Variance; Angelman Syndrome; Animals; Blotting, Western; Brain; Disease Models, Animal; | 2010 |
Diphenyl diselenide-induced seizures in rat pups: possible interaction with GABAergic system.
Topics: Acetanilides; Animals; Animals, Newborn; Benzene Derivatives; Diazepam; Disease Models, Animal; Dose | 2010 |
Alterations in the hippocampal endocannabinoid system in diet-induced obese mice.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Dietary Fats; Disease Models, Animal; E | 2010 |
Decreased GABA receptor in the striatum and spatial recognition memory deficit in epileptic rats: effect of Bacopa monnieri and bacoside-A.
Topics: Animals; Anticonvulsants; Bacopa; Basal Ganglia; Behavior, Animal; Bicuculline; Binding, Competitive | 2010 |
Densities of glutamatergic and GABAergic presynaptic terminals are altered in experimental cortical dysplasia.
Topics: Analysis of Variance; Animals; Animals, Newborn; Cerebral Cortex; Disease Models, Animal; Embryo, Ma | 2010 |
Selective changes in inhibition as determinants for limited hyperexcitability in the insular cortex of epileptic rats.
Topics: Action Potentials; Animals; Disease Models, Animal; Electrophysiology; Epilepsy, Temporal Lobe; gamm | 2010 |
Gabapentin for spasticity and autonomic dysreflexia after severe spinal cord injury.
Topics: Amines; Animals; Autonomic Dysreflexia; Cyclohexanecarboxylic Acids; Disease Models, Animal; Female; | 2011 |
Selective potentiation of gabapentin-mediated antinociception in the rat formalin test by the nicotinic acetylcholine receptor agonist ABT-594.
Topics: Amines; Analgesics; Animals; Azetidines; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-R | 2010 |
Plasticity of postsynaptic, but not presynaptic, GABAB receptors in SSADH deficient mice.
Topics: Adenosine; Animals; Baclofen; Disease Models, Animal; GABA Antagonists; gamma-Aminobutyric Acid; Mic | 2010 |
Role of GABAergic neurones in the nucleus tractus solitarii in modulation of cardiovascular activity.
Topics: Animals; Baroreflex; Blood Pressure; Cardiovascular System; Disease Models, Animal; GABA-A Receptor | 2010 |
Selective reduction of cholecystokinin-positive basket cell innervation in a model of temporal lobe epilepsy.
Topics: Animals; CA1 Region, Hippocampal; Cholecystokinin; Disease Models, Animal; Epilepsy, Temporal Lobe; | 2010 |
Glutamate and GABA in the balance: convergent pathways sustain seizures during status epilepticus.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Receptors, GABA-A; Receptor | 2010 |
Lack of effect of intranigral transplants of a GABAergic cell line on absence seizures.
Topics: Animals; Body Weight; Cell Line; Cell Transplantation; Disease Models, Animal; Epilepsy, Absence; ga | 2010 |
A tropomyosine receptor kinase inhibitor blocks spinal neuroplasticity essential for the anti-hypersensitivity effects of gabapentin and clonidine in rats with peripheral nerve injury.
Topics: Acetylcholine; Amines; Analgesics; Animals; Carbazoles; Choline O-Acetyltransferase; Clonidine; Cycl | 2011 |
Reduced GABAergic inhibition explains cortical hyperexcitability in the wobbler mouse model of ALS.
Topics: Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Immunohisto | 2011 |
Defective GABAergic neurotransmission and pharmacological rescue of neuronal hyperexcitability in the amygdala in a mouse model of fragile X syndrome.
Topics: Amygdala; Animals; Disease Models, Animal; Evoked Potentials; Fragile X Mental Retardation Protein; | 2010 |
Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U.
Topics: Animals; Apoptosis; Atrophy; Brain; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Caspase 3; C | 2010 |
Cell-mediated neuroprotection in a mouse model of human tauopathy.
Topics: Age Factors; Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Differentiation; Cell Trans | 2010 |
Above-level mechanical hyperalgesia in rats develops after incomplete spinal cord injury but not after cord transection, and is reversed by amitriptyline, morphine and gabapentin.
Topics: Amines; Amitriptyline; Analgesics; Animals; Cell Count; Cross-Over Studies; Cyclohexanecarboxylic Ac | 2010 |
Receptors with low affinity for neurosteroids and GABA contribute to tonic inhibition of granule cells in epileptic animals.
Topics: Action Potentials; Affinity Labels; Animals; Blotting, Western; Dentate Gyrus; Disease Models, Anima | 2010 |
Prenatal ethanol exposure attenuates GABAergic inhibition in basolateral amygdala leading to neuronal hyperexcitability and anxiety-like behavior of adult rat offspring.
Topics: Amygdala; Animals; Anxiety; Cornified Envelope Proline-Rich Proteins; Disease Models, Animal; Ethano | 2010 |
Additive interactions of pregabalin with lamotrigine, oxcarbazepine and topiramate in the mouse maximal electroshock-induced seizure model: a type I isobolographic analysis for non-parallel dose-response relationship curves.
Topics: Animals; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; | 2010 |
Differential distribution of activated spinal neurons containing glycine and/or GABA and expressing c-fos in acute and chronic pain models.
Topics: Animals; Capsaicin; Cell Count; Disease Models, Animal; Formaldehyde; gamma-Aminobutyric Acid; Gene | 2010 |
Late prenatal immune activation in mice leads to behavioral and neurochemical abnormalities relevant to the negative symptoms of schizophrenia.
Topics: Animals; Behavior, Animal; Central Nervous System Viral Diseases; Disease Models, Animal; Dopamine; | 2010 |
Characterization of the acute and persistent pain state present in K/BxN serum transfer arthritis.
Topics: Activating Transcription Factor 3; Amines; Analgesics; Analysis of Variance; Animals; Arthritis, Rhe | 2010 |
The effects of midazolam and D-cycloserine on the release of glutamate and GABA in the basolateral amygdala of low and high anxiety rats during extinction trial of a conditioned fear test.
Topics: Amygdala; Analysis of Variance; Animals; Anxiety; Anxiety Disorders; Conditioning, Classical; Cyclos | 2010 |
Elevated BDNF after cocaine withdrawal facilitates LTP in medial prefrontal cortex by suppressing GABA inhibition.
Topics: Animals; Animals, Newborn; Biophysics; Brain-Derived Neurotrophic Factor; Carbazoles; Cocaine; Cocai | 2010 |
Up-regulation of GABA transporters and GABA(A) receptor α1 subunit in tremor rat hippocampus.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; GABA Plasma Membrane Transport Proteins; | 2010 |
Hypoglycemia induced behavioural deficit and decreased GABA receptor, CREB expression in the cerebellum of streptozoticin induced diabetic rats.
Topics: Analysis of Variance; Animals; Cerebellum; CREB-Binding Protein; Diabetes Mellitus, Experimental; Di | 2010 |
Damage of GABAergic neurons in the medial septum impairs spatial working memory and extinction of active avoidance: effects on proactive interference.
Topics: Animals; Choline O-Acetyltransferase; Diagonal Band of Broca; Disease Models, Animal; GABA Plasma Me | 2011 |
Intrathecal gabapentin and clonidine synergistically inhibit allodynia in spinal nerve-ligated rats.
Topics: Amines; Animals; Clonidine; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relat | 2010 |
Low dose of donepezil improves gabapentin analgesia in the rat spared nerve injury model of neuropathic pain: single and multiple dosing studies.
Topics: Amines; Analgesics; Animals; Cholinesterase Inhibitors; Cyclohexanecarboxylic Acids; Disease Models, | 2010 |
Correction of respiratory disorders in a mouse model of Rett syndrome.
Topics: Animals; Apnea; Disease Models, Animal; Female; GABA Antagonists; gamma-Aminobutyric Acid; Male; Met | 2010 |
Neuroprotective effects of gabapentin in experimental spinal cord injury.
Topics: Amines; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Cyclohexanecarboxylic Acids; Di | 2010 |
GABAergic regulation of auditory sensory gating in low- and high-anxiety rats submitted to a fear conditioning procedure.
Topics: Acoustic Stimulation; Animals; Anxiety; Behavior, Animal; Benzodiazepines; Bicuculline; Clonixin; Co | 2010 |
The 4-aminopyridine in vitro epilepsy model analyzed with a perforated multi-electrode array.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Bicuculline; CA3 Region, Hippocampal; Disease Models, Ani | 2011 |
A novel rat forelimb model of neuropathic pain produced by partial injury of the median and ulnar nerves.
Topics: Amines; Analgesics; Animals; Behavior, Animal; CD11b Antigen; Cold Temperature; Cyclohexanecarboxyli | 2011 |
GABAergic pathway in a rat model of chronic neuropathic pain: modulation after intrathecal transplantation of a human neuronal cell line.
Topics: Animals; Cell Line; Chronic Disease; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamate Deca | 2011 |
Striatal ablation of GABAergic neurons prevents the in vivo neuroprotective effect of DCG-IV against the MPP+-induced neurotoxicity on dopaminergic nerve terminals.
Topics: Animals; Corpus Striatum; Cyclopropanes; Disease Models, Animal; Dopamine; gamma-Aminobutyric Acid; | 2010 |
GABAergic transmission modulates ethanol excitation of ventral tegmental area dopamine neurons.
Topics: Animals; Disease Models, Animal; Dopamine; Ethanol; gamma-Aminobutyric Acid; Male; Neurons; Organ Cu | 2011 |
Cellular correlates of anxiety in CA1 hippocampal pyramidal cells of 5-HT1A receptor knockout mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Carbolines; Diazepam; Disease Models, Animal; Excitatory Post | 2011 |
Reducing excessive GABA-mediated tonic inhibition promotes functional recovery after stroke.
Topics: Animals; Benzodiazepines; Cerebral Infarction; Disease Models, Animal; Drug Inverse Agonism; GABA An | 2010 |
L-ornithine attenuates corticotropin-releasing factor-induced stress responses acting at GABAA receptors in neonatal chicks.
Topics: Animals; Chickens; Corticotropin-Releasing Hormone; Disease Models, Animal; gamma-Aminobutyric Acid; | 2011 |
Upregulation of barrel GABAergic neurons is associated with cross-modal plasticity in olfactory deficit.
Topics: Action Potentials; Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Mice; Neurons; Olfactio | 2010 |
Impaired hippocampal synaptic plasticity in C6 glioma-bearing rats.
Topics: Animals; Body Weight; Brain Neoplasms; Cell Line, Tumor; Chromatography, High Pressure Liquid; Disea | 2011 |
Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes.
Topics: Animals; Autistic Disorder; Brain; Compulsive Behavior; Disease Models, Animal; Electroencephalograp | 2010 |
Pregabalin attenuates place escape/avoidance behavior in a rat model of spinal cord injury.
Topics: Analgesics; Animals; Anxiety; Avoidance Learning; Behavior, Animal; Disease Models, Animal; Fear; Fe | 2011 |
The GABAergic deficit hypothesis of major depressive disorder.
Topics: Animals; Antidepressive Agents; Brain; Depressive Disorder, Major; Disease Models, Animal; gamma-Ami | 2011 |
The GABAergic deficit hypothesis of major depressive disorder.
Topics: Animals; Antidepressive Agents; Brain; Depressive Disorder, Major; Disease Models, Animal; gamma-Ami | 2011 |
The GABAergic deficit hypothesis of major depressive disorder.
Topics: Animals; Antidepressive Agents; Brain; Depressive Disorder, Major; Disease Models, Animal; gamma-Ami | 2011 |
The GABAergic deficit hypothesis of major depressive disorder.
Topics: Animals; Antidepressive Agents; Brain; Depressive Disorder, Major; Disease Models, Animal; gamma-Ami | 2011 |
Pancreatitis-associated protein-I and pancreatitis-associated protein-III expression in a rat model of kainic acid-induced seizure.
Topics: Aminopeptidases; Animals; Antigens, Neoplasm; Biomarkers, Tumor; Disease Models, Animal; Epilepsy, T | 2011 |
Failure of NMDA receptor hypofunction to induce a pathological reduction in PV-positive GABAergic cell markers.
Topics: Animals; Blotting, Western; Brain; Disease Models, Animal; Excitatory Amino Acid Antagonists; gamma- | 2011 |
Time-domain features of epileptic spikes as potential bio-markers of the epileptogenesis process.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biomarkers; Co | 2010 |
Molecular basis for the dosing time-dependency of anti-allodynic effects of gabapentin in a mouse model of neuropathic pain.
Topics: Amines; Animals; Calcium Channels; Circadian Rhythm; Cyclohexanecarboxylic Acids; Disease Models, An | 2010 |
Abnormalities in GABAergic synaptic transmission of intralaminar thalamic neurons in a genetic rat model of absence epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Absence; gamma-Aminobutyric Acid; Inhibitory Postsynaptic | 2011 |
Selective loss and axonal sprouting of GABAergic interneurons in the sclerotic hippocampus induced by LiCl-pilocarpine.
Topics: Animals; Axons; Disease Models, Animal; gamma-Aminobutyric Acid; Hippocampus; Interneurons; Lithium | 2011 |
Fewer GABAergic interneurons, heightened anxiety and decreased high-frequency electroencephalogram components in Bronx waltzer mice, a model of hereditary deafness.
Topics: Animals; Anxiety; Brain Waves; Cerebrum; Deafness; Disease Models, Animal; Electroencephalography; E | 2011 |
Gabapentin and pregabalin inhibit the itch-associated response induced by the repeated application of oxazolone in mice.
Topics: Amines; Animals; Calcium Channels; Chronic Disease; Cyclohexanecarboxylic Acids; Disease Models, Ani | 2011 |
[The protective effect of nicotine on dopaminergic neuron of Parkinson's disease mice].
Topics: Animals; Caudate Nucleus; Disease Models, Animal; Dopaminergic Neurons; Female; gamma-Aminobutyric A | 2007 |
Ultrastructural GABA immunocytochemistry in the mossy fiber terminals of Wistar and genetic absence epileptic rats receiving amygdaloid kindling stimulations.
Topics: Amygdala; Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy, Absence; Epilepsy, Temporal Lobe | 2011 |
Enhanced glutamate, IP3 and cAMP activity in the cerebral cortex of unilateral 6-hydroxydopamine induced Parkinson's rats: effect of 5-HT, GABA and bone marrow cell supplementation.
Topics: Animals; Behavior, Animal; Bone Marrow Cells; Bone Marrow Transplantation; Cerebral Cortex; Cyclic A | 2011 |
Calcium channel alpha-2-delta-1 protein upregulation in dorsal spinal cord mediates spinal cord injury-induced neuropathic pain states.
Topics: Amines; Analgesics; Animals; Calcium Channels; Calcium Channels, L-Type; Cyclohexanecarboxylic Acids | 2011 |
Study of epileptiform activity in cerebral ganglion of mud crab Scylla serrata.
Topics: Animals; Anticonvulsants; Brachyura; Convulsants; Disease Models, Animal; Epilepsy; gamma-Aminobutyr | 2011 |
Molecular alterations underlying epileptogenesis after prolonged febrile seizure and modulation by erythropoietin.
Topics: Animals; Animals, Newborn; Anticonvulsants; Apoptosis; Blood-Brain Barrier; Brain; CD11b Antigen; Ce | 2011 |
Dopamine D3-like receptors modulate anxiety-like behavior and regulate GABAergic transmission in the rat lateral/basolateral amygdala.
Topics: Amygdala; Animals; Anxiety; Benzopyrans; Biphenyl Compounds; Disease Models, Animal; Dopamine Agonis | 2011 |
Estradiol acts through nuclear- and membrane-initiated mechanisms to maintain a balance between GABAergic and glutamatergic signaling in the brain: implications for hormone replacement therapy.
Topics: Affect; Animals; Brain; Cell Nucleus; Cognition; Disease Models, Animal; Estradiol; Female; gamma-Am | 2010 |
Altered spontaneous synaptic inhibition in an animal model of cerebral heterotopias.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Neural Inhibition; Neurons; Organ Culture | 2011 |
Reactive oxygen species contribute to neuropathic pain by reducing spinal GABA release.
Topics: Analysis of Variance; Animals; Bicuculline; Cyclic N-Oxides; Disease Models, Animal; Dose-Response R | 2011 |
Network oscillations in rod-degenerated mouse retinas.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Age Factors; Animals; Carbenoxolone; Cyclooxygenase | 2011 |
The benzodiazepine Midazolam mitigates the breathing defects of Mecp2-deficient mice.
Topics: Animals; Benzodiazepines; Disease Models, Animal; GABA Agonists; gamma-Aminobutyric Acid; Methyl-CpG | 2011 |
The neurochemical basis for the treatment of autism spectrum disorders and Fragile X Syndrome.
Topics: Animals; Autistic Disorder; Disease Models, Animal; Fragile X Syndrome; gamma-Aminobutyric Acid; Glu | 2011 |
Retrieval of conditioned fear activates the basolateral and intercalated nucleus of amygdala.
Topics: Amygdala; Animals; Brain Chemistry; Conditioning, Psychological; Disease Models, Animal; Fear; gamma | 2011 |
The GABA B receptor agonist CGP44532 and the positive modulator GS39783 reverse some behavioural changes related to positive syndromes of psychosis in mice.
Topics: Animals; Behavior, Animal; Catalepsy; Cyclopentanes; Disease Models, Animal; Dose-Response Relations | 2011 |
Antidepressant effect of GABA-rich monascus-fermented product on forced swimming rat model.
Topics: Animals; Antidepressive Agents; Biogenic Monoamines; Brain Chemistry; Depression; Disease Models, An | 2011 |
Sleep disturbances in a neuropathic pain-like condition in the mouse are associated with altered GABAergic transmission in the cingulate cortex.
Topics: Analysis of Variance; Animals; Anisoles; Disease Models, Animal; Electroencephalography; Electromyog | 2011 |
Axonal remodeling for motor recovery after traumatic brain injury requires downregulation of γ-aminobutyric acid signaling.
Topics: Animals; Apoptosis Regulatory Proteins; Axons; Brain Injuries; Cerebral Cortex; Cytoskeletal Protein | 2011 |
Chronic intrathecal infusion of gabapentin prevents nerve ligation-induced pain in rats.
Topics: Amines; Analgesics, Non-Narcotic; Animals; Cauda Equina; Cyclohexanecarboxylic Acids; Disease Models | 2011 |
7-Nitroindazole, but not NG-nitro-L-arginine, enhances the anticonvulsant activity of pregabalin in the mouse maximal electroshock-induced seizure model.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; | 2011 |
Antihypertensive effects of Lactobacillus-fermented milk orally administered to spontaneously hypertensive rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Cultured | 2011 |
Antihypertensive effects of Lactobacillus-fermented milk orally administered to spontaneously hypertensive rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Cultured | 2011 |
Antihypertensive effects of Lactobacillus-fermented milk orally administered to spontaneously hypertensive rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Cultured | 2011 |
Antihypertensive effects of Lactobacillus-fermented milk orally administered to spontaneously hypertensive rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Cultured | 2011 |
Antihypertensive effects of Lactobacillus-fermented milk orally administered to spontaneously hypertensive rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Cultured | 2011 |
Antihypertensive effects of Lactobacillus-fermented milk orally administered to spontaneously hypertensive rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Cultured | 2011 |
Antihypertensive effects of Lactobacillus-fermented milk orally administered to spontaneously hypertensive rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Cultured | 2011 |
Antihypertensive effects of Lactobacillus-fermented milk orally administered to spontaneously hypertensive rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Cultured | 2011 |
Antihypertensive effects of Lactobacillus-fermented milk orally administered to spontaneously hypertensive rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Cultured | 2011 |
Altered GABA transmission in a mouse model of increased trait anxiety.
Topics: Amygdala; Analysis of Variance; Animals; Anxiety; Disease Models, Animal; gamma-Aminobutyric Acid; G | 2011 |
Developmental GABAergic deficit enhances methamphetamine-induced apoptosis.
Topics: Animals; Apoptosis; Central Nervous System Stimulants; Disease Models, Animal; Dizocilpine Maleate; | 2011 |
Impaired GABA and glycine transmission triggers cardinal features of rapid eye movement sleep behavior disorder in mice.
Topics: Analysis of Variance; Animals; Brain; Central Nervous System Depressants; Clonazepam; Disease Models | 2011 |
Acupuncture to point Baihui prevents ischemia-induced functional impairment of cortical GABAergic neurons.
Topics: Action Potentials; Acupuncture Points; Animals; Brain Ischemia; Cerebral Cortex; Disease Models, Ani | 2011 |
Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord.
Topics: Analgesics; Animals; Diazepam; Disease Models, Animal; Excitatory Postsynaptic Potentials; Flumazeni | 2011 |
Synergistic antihypersensitive effects of pregabalin and tapentadol in a rat model of neuropathic pain.
Topics: Animals; Antihypertensive Agents; Behavior, Animal; Disease Models, Animal; Drug Synergism; gamma-Am | 2011 |
The median effective dose of ketamine and gabapentin in opioid-induced hyperalgesia in rats: an isobolographic analysis of their interaction.
Topics: Amines; Analgesics; Analgesics, Opioid; Analysis of Variance; Animals; Cyclohexanecarboxylic Acids; | 2011 |
The effects of gabapentin in two animal models of co-morbid anxiety and visceral hypersensitivity.
Topics: Amines; Animals; Anxiety; Comorbidity; Cyclohexanecarboxylic Acids; Disease Models, Animal; Female; | 2011 |
Effects of high frequency electrical stimulation and R-verapamil on seizure susceptibility and glutamate and GABA release in a model of phenytoin-resistant seizures.
Topics: Animals; Disease Models, Animal; Disease Susceptibility; Drug Resistance; Electric Stimulation; Extr | 2011 |
Retinal remodeling in the Tg P347L rabbit, a large-eye model of retinal degeneration.
Topics: Adult; Animals; Animals, Genetically Modified; Disease Models, Animal; Disease Progression; Electror | 2011 |
Release of growth factors by neuronal precursor cells as a treatment for diseases with tau pathology.
Topics: Analysis of Variance; Animals; Brain-Derived Neurotrophic Factor; Cell Differentiation; Disease Mode | 2011 |
Do the quantitative relationships of synaptic junctions and terminals in the thalamus of genetic absence epilepsy rats from Strasbourg (GAERS) differ from those in normal control Wistar rats.
Topics: Animals; Disease Models, Animal; Epilepsy, Absence; gamma-Aminobutyric Acid; Microscopy, Electron, T | 2012 |
Closed traumatic brain injury model in sheep mimicking high-velocity, closed head trauma in humans.
Topics: Animals; Aspartic Acid; Brain; Brain Injuries; Carbon Dioxide; Disease Models, Animal; Electron Spin | 2011 |
Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons.
Topics: Agouti-Related Protein; Animals; Brain; Disease Models, Animal; Excitatory Postsynaptic Potentials; | 2011 |
Neurobiological activity of Parawixin 10, a novel anticonvulsant compound isolated from Parawixia bistriata spider venom (Araneidae: Araneae).
Topics: Analysis of Variance; Animals; Anticonvulsants; Ataxia; Cerebral Cortex; Chromatography, High Pressu | 2011 |
Increase of hippocampal glutamate after electroconvulsive treatment: a quantitative proton MR spectroscopy study at 9.4 T in an animal model of depression.
Topics: Animals; Choline; Depression; Disease Models, Animal; Electroconvulsive Therapy; gamma-Aminobutyric | 2012 |
Recruitment of prefrontal cortical endocannabinoid signaling by glucocorticoids contributes to termination of the stress response.
Topics: Animals; Arachidonic Acids; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Corticosterone; Dise | 2011 |
Pregabalin modulation of spinal and brainstem visceral nociceptive processing.
Topics: Afferent Pathways; Analgesics; Animals; Brain Stem; Disease Models, Animal; gamma-Aminobutyric Acid; | 2011 |
α4β2 nicotinic acetylcholine receptors on dopaminergic neurons mediate nicotine reward and anxiety relief.
Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Body Temperature; Bridged Bicyclo Compound | 2011 |
Manual acupuncture inhibits mechanical hypersensitivity induced by spinal nerve ligation in rats.
Topics: Acupuncture Points; Acupuncture Therapy; Amines; Analgesics; Analysis of Variance; Animals; Cyclohex | 2011 |
Thymoquinone produced antianxiety-like effects in mice through modulation of GABA and NO levels.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Benzoquinones; Brain; Cyclic GMP; Diazepam; | 2011 |
Early age conductive hearing loss causes audiogenic seizure and hyperacusis behavior.
Topics: Acoustic Stimulation; Age Factors; Aging; Animals; Anticonvulsants; Auditory Perception; Behavior, A | 2011 |
Decrease of GABAergic markers and arc protein expression in the frontal cortex by intraventricular 192 IgG-saporin.
Topics: Acetylcholinesterase; Animals; Antibodies, Monoclonal; Blotting, Western; Choline O-Acetyltransferas | 2011 |
Pain-related deactivation of medial prefrontal cortical neurons involves mGluR1 and GABA(A) receptors.
Topics: Action Potentials; Animals; Arthritis, Experimental; Benzoates; Bicuculline; Disease Models, Animal; | 2011 |
Astrocytes promote peripheral nerve injury-induced reactive synaptogenesis in the neonatal CNS.
Topics: Age Factors; Aldehyde Dehydrogenase 1 Family; Amines; Animals; Animals, Newborn; Astrocytes; Biophys | 2011 |
Sepsis-induced alterations in sleep of rats.
Topics: Animals; Behavior, Animal; Body Temperature; Brain; Cecum; Circadian Rhythm; Disease Models, Animal; | 2011 |
Scopolamine impairs behavioural function and arginine metabolism in the rat dentate gyrus.
Topics: Amino Acids; Animals; Arginine; Behavioral Symptoms; Body Weight; Brain Chemistry; Cholinergic Antag | 2011 |
Cognitive dysfunctions induced by a cholinergic blockade and Aβ 25-35 peptide are attenuated by salvianolic acid B.
Topics: Amyloid beta-Peptides; Animals; Animals, Newborn; Benzofurans; Cholinergic Antagonists; Cholinestera | 2011 |
Pharmacological and behavioral characterization of the saphenous chronic constriction injury model of neuropathic pain in rats.
Topics: Amines; Amitriptyline; Analgesics; Animals; Benzoxazines; Chronic Disease; Constriction; Cyclohexane | 2011 |
Enhanced GABAergic tone in the ventral pallidum: memory of unpleasant experiences?
Topics: Animals; Behavior, Animal; Bicuculline; Depression; Disease Models, Animal; Enzyme Inhibitors; GABA- | 2011 |
Interactions of pregabalin with gabapentin, levetiracetam, tiagabine and vigabatrin in the mouse maximal electroshock-induced seizure model: a type II isobolographic analysis.
Topics: Amines; Animals; Anticonvulsants; Avoidance Learning; Confidence Intervals; Cyclohexanecarboxylic Ac | 2012 |
Rewarding electrical brain stimulation in rats after peripheral nerve injury: decreased facilitation by commonly abused prescription opioids.
Topics: Adenosine; Amines; Analgesics; Analgesics, Opioid; Animals; Brain; Clonidine; Cyclohexanecarboxylic | 2011 |
Functional changes in the septal GABAergic system of animals with a model of temporal lobe epilepsy.
Topics: Animals; Brain; Disease Models, Animal; Electrophysiology; Epilepsy, Temporal Lobe; gamma-Aminobutyr | 2011 |
Characterization of a new animal model for evaluation and treatment of back pain due to lumbar facet joint osteoarthritis.
Topics: Analgesics; Animals; Back Pain; Cartilage, Articular; Disease Models, Animal; gamma-Aminobutyric Aci | 2011 |
Social stress promotes and γ-aminobutyric acid inhibits tumor growth in mouse models of non-small cell lung cancer.
Topics: Animals; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cyclic AMP Response El | 2012 |
Activation of orexin 1 receptors in the periaqueductal gray of male rats leads to antinociception via retrograde endocannabinoid (2-arachidonoylglycerol)-induced disinhibition.
Topics: Analysis of Variance; Animals; Animals, Newborn; Arachidonic Acids; Benzoxazines; Benzoxazoles; Biph | 2011 |
The rat intervertebral disk degeneration pain model: relationships between biological and structural alterations and pain.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Intervertebral Disc Degeneration; Low Back | 2011 |
Genetic differences in the modulation of accumbal glutamate and γ-amino butyric acid levels after cocaine-induced reinstatement.
Topics: Analysis of Variance; Animals; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine | 2013 |
Drug-induced GABA transporter currents enhance GABA release to induce opioid withdrawal behaviors.
Topics: Analysis of Variance; Animals; Disease Models, Animal; GABA Antagonists; GABA Plasma Membrane Transp | 2011 |
The GABA(A) receptor agonist THIP ameliorates specific behavioral deficits in the mouse model of fragile X syndrome.
Topics: Animals; Behavior, Animal; Conditioning, Psychological; Disease Models, Animal; Fear; Fragile X Ment | 2011 |
Possible involvement of monoaminergic neurotransmission in antidepressant-like activity of Emblica officinalis fruits in mice.
Topics: Animals; Antidepressive Agents; Ascorbic Acid; Biogenic Monoamines; Depression; Disease Models, Anim | 2012 |
Decreased intracellular GABA levels contribute to spinal cord stimulation-induced analgesia in rats suffering from painful peripheral neuropathy: the role of KCC2 and GABA(A) receptor-mediated inhibition.
Topics: Analgesia; Animals; Chronic Pain; Disease Models, Animal; Electric Stimulation Therapy; gamma-Aminob | 2012 |
Impaired glutamatergic and GABAergic function at early age in AβPPswe-PS1dE9 mice: implications for Alzheimer's disease.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Disease Models, Animal; gam | 2012 |
Intraspinal transplantation of GABAergic neural progenitors attenuates neuropathic pain in rats: a pharmacologic and neurophysiological evaluation.
Topics: Action Potentials; Analysis of Variance; Animals; Disease Models, Animal; Embryo, Mammalian; Embryon | 2012 |
Glutamic acid decarboxylase immunoreactivity in the mossy fiber terminals of the hippocampus of genetic absence epileptic rats.
Topics: Animals; CA3 Region, Hippocampal; Dentate Gyrus; Disease Models, Animal; Epilepsy, Absence; gamma-Am | 2011 |
Unbalance of CB1 receptors expressed in GABAergic and glutamatergic neurons in a transgenic mouse model of Huntington's disease.
Topics: Action Potentials; Analysis of Variance; Animals; Benzoxazines; Brain; Disease Models, Animal; Drona | 2012 |
Differentiation and functional incorporation of embryonic stem cell-derived GABAergic interneurons in the dentate gyrus of mice with temporal lobe epilepsy.
Topics: Animals; Cell Line; Dentate Gyrus; Disease Models, Animal; Embryonic Stem Cells; Epilepsy, Temporal | 2012 |
[Cerebrovascular effects of GABA conjugate with arachidonic acid under conditions of separate and combined vascular pathology of brain and heart].
Topics: Animals; Arachidonic Acid; Blood Pressure; Brain; Brain Ischemia; Carotid Artery, Common; Cerebrovas | 2011 |
Comparison of central versus peripheral delivery of pregabalin in neuropathic pain states.
Topics: Animals; Behavior, Animal; Blotting, Western; Calcium Channels; Calcium Channels, L-Type; Central Ne | 2012 |
Sprouting of colonic afferent central terminals and increased spinal mitogen-activated protein kinase expression in a mouse model of chronic visceral hypersensitivity.
Topics: Afferent Pathways; Analysis of Variance; Animals; Calbindins; Calcitonin Gene-Related Peptide; Chole | 2012 |
Noisy galvanic vestibular stimulation promotes GABA release in the substantia nigra and improves locomotion in hemiparkinsonian rats.
Topics: Acoustic Stimulation; Animals; Behavior, Animal; Disease Models, Animal; Female; gamma-Aminobutyric | 2012 |
Antinociceptive effect of Butea monosperma on vincristine-induced neuropathic pain model in rats.
Topics: Analgesics; Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Behavior, Animal; Butea; Calci | 2013 |
Opa1 is essential for retinal ganglion cell synaptic architecture and connectivity.
Topics: Animals; Disease Models, Animal; Disks Large Homolog 4 Protein; gamma-Aminobutyric Acid; Glutamic Ac | 2012 |
New directions in reducing stress effects on cancer.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Disease Models, Animal; GABA Agents; gamma-Aminobutyric Aci | 2012 |
Evaluation of anxiolytic effect and withdrawal anxiety in chronic intermittent diazepam treatment in rats.
Topics: Amines; Animals; Anti-Anxiety Agents; Anxiety; Cyclohexanecarboxylic Acids; Diazepam; Disease Models | 2012 |
Assessing carrageenan-induced locomotor activity impairment in rats: comparison with evoked endpoint of acute inflammatory pain.
Topics: Acute Pain; Adrenergic Uptake Inhibitors; Amines; Amphetamine; Analgesics; Analgesics, Opioid; Anima | 2012 |
Pharmacological characterization of lysophosphatidic acid-induced pain with clinically relevant neuropathic pain drugs.
Topics: Amines; Analgesics; Animals; Calcium Channels; Cyclohexanecarboxylic Acids; Disease Models, Animal; | 2012 |
Decreased GABA receptor in the cerebral cortex of epileptic rats: effect of Bacopa monnieri and Bacoside-A.
Topics: Animals; Bacopa; Cerebral Cortex; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Gene Ex | 2012 |
The combined predictive capacity of rat models of algogen-induced and neuropathic hypersensitivity to clinically used analgesics varies with nociceptive endpoint and consideration of locomotor function.
Topics: Amines; Analgesics; Animals; Capsaicin; Cyclohexanecarboxylic Acids; Disease Models, Animal; Duloxet | 2012 |
Influence of carvedilol on anticonvulsant effect of gabapentin.
Topics: Amines; Analysis of Variance; Animals; Anticonvulsants; Brain; Carbazoles; Carvedilol; Convulsants; | 2011 |
Erysothrine, an alkaloid extracted from flowers of Erythrina mulungu Mart. ex Benth: evaluating its anticonvulsant and anxiolytic potential.
Topics: Alkaloids; Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Convulsants; Diazepam; Disease Mo | 2012 |
Glucose metabolism via the pentose phosphate pathway, glycolysis and Krebs cycle in an orthotopic mouse model of human brain tumors.
Topics: Animals; Brain Neoplasms; Carcinoma, Renal Cell; Citric Acid Cycle; Disease Models, Animal; gamma-Am | 2012 |
The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model.
Topics: Administration, Oral; Amines; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Cyclohexanecarb | 2012 |
Astrocytes convert network excitation to tonic inhibition of neurons.
Topics: Animals; Astrocytes; Disease Models, Animal; Epilepsy; Feedback, Physiological; GABA Plasma Membrane | 2012 |
Spinal mechanism underlying the antiallodynic effect of gabapentin studied in the mouse spinal nerve ligation model.
Topics: Amines; Analgesics; Animals; Calcium Channels; CD11b Antigen; Cyclohexanecarboxylic Acids; Disease M | 2012 |
Etodolac, a cyclooxygenase-2 inhibitor, attenuates paclitaxel-induced peripheral neuropathy in a mouse model of mechanical allodynia.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diclofenac; Disease Models, Animal; Drug Int | 2012 |
Gabapentin augments the antihyperalgesic effects of diclofenac sodium through spinal action in a rat postoperative pain model.
Topics: Amines; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclohexanecarbo | 2012 |
Endpoints of drug discovery for menopausal vasomotor symptoms: interpretation of data from a proxy of disease.
Topics: Acetamides; Amines; Animals; Body Temperature Regulation; Cyclohexanecarboxylic Acids; Cyclohexanols | 2012 |
Effect of the anticonvulsant medications pregabalin and lamotrigine on urodynamic parameters in an animal model of neurogenic detrusor overactivity.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Female; gamma-Am | 2012 |
Evaluation of aqueous and ethanolic extracts of saffron, Crocus sativus L., and its constituents, safranal and crocin in allodynia and hyperalgesia induced by chronic constriction injury model of neuropathic pain in rats.
Topics: Acetone; Amines; Analgesics; Animals; Behavior, Animal; Carotenoids; Constriction; Crocus; Cyclohexa | 2012 |
Excitability and synaptic alterations in the cerebellum of APP/PS1 mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cerebellum; Disease Models, Animal; gamma-Aminobu | 2012 |
m-Trifluoromethyl diphenyl diselenide attenuates glutaric acid-induced seizures and oxidative stress in rat pups: involvement of the γ-aminobutyric acidergic system.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Anticonvulsants; Brain Diseases, Metabolic; Disease M | 2012 |
Beneficial effects of γ-aminobutyric acid on right ventricular pressure and pulmonary vascular remodeling in experimental pulmonary hypertension.
Topics: Animals; Blood Pressure; Disease Models, Animal; Endothelin-1; gamma-Aminobutyric Acid; Heart Ventri | 2012 |
Modeling interneuron dysfunction in schizophrenia.
Topics: Animals; Cerebral Cortex; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamate Decarboxylase; | 2012 |
Activation of GABAergic pathway by hypocretin in the median raphe nucleus (MRN) mediates stress-induced theta rhythm in rats.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Electroencephalography; Electroshock; GABA Ag | 2012 |
Systemic pregabalin attenuates sensorimotor responses and medullary glutamate release in inflammatory tooth pain model.
Topics: Analgesics; Animals; Dental Pulp; Disease Models, Animal; Electromyography; Facial Muscles; gamma-Am | 2012 |
Gabapentin reduces CX3CL1 signaling and blocks spinal microglial activation in monoarthritic rats.
Topics: Amines; Animals; Arthritis; Calcium Channels, L-Type; Chemokine CX3CL1; CX3C Chemokine Receptor 1; C | 2012 |
Inactivation of the constitutively active ghrelin receptor attenuates limbic seizure activity in rodents.
Topics: Analysis of Variance; Animals; Anticonvulsants; Calcium; Disease Models, Animal; Disease Susceptibil | 2012 |
Sildenafil influences the anticonvulsant activity of vigabatrin and gabapentin in the timed pentylenetetrazole infusion test in mice.
Topics: Amines; Animals; Anticonvulsants; Avoidance Learning; Cyclohexanecarboxylic Acids; Disease Models, A | 2012 |
A novel role of intestine epithelial GABAergic signaling in regulating intestinal fluid secretion.
Topics: Adult; Animals; Autocrine Communication; Blotting, Western; Cell Line; Diarrhea; Disease Models, Ani | 2012 |
Behavioral and EEG effects of GABAergic manipulation of the nigro-tectal pathway in the Wistar audiogenic rat (WAR) strain II: an EEG wavelet analysis and retrograde neuronal tracer approach.
Topics: Acoustic Stimulation; Animals; Behavior, Animal; Bicuculline; Brain Waves; Disease Models, Animal; E | 2012 |
Effects of anesthetic regimes on inflammatory responses in a rat model of acute lung injury.
Topics: Acute Lung Injury; Analysis of Variance; Anesthesia; Anesthetics, Dissociative; Anesthetics, General | 2012 |
Ondansetron reverses antihypersensitivity from clonidine in rats after peripheral nerve injury: role of γ-aminobutyric acid in α2-adrenoceptor and 5-HT3 serotonin receptor analgesia.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesia; Animals; Clonidine; Disease Models, Animal; gamma-A | 2012 |
Lack of behavioral and cognitive effects of chronic ethosuximide and gabapentin treatment in the Ts65Dn mouse model of Down syndrome.
Topics: Amines; Animals; Anticonvulsants; Behavior, Animal; Cognition; Cyclohexanecarboxylic Acids; Disease | 2012 |
Acute augmentation of epoxygenated fatty acid levels rapidly reduces pain-related behavior in a rat model of type I diabetes.
Topics: Amines; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Diabetes Mellitus, Experimental; Dia | 2012 |
Elucidation of neuroprotective role of endogenous GABA and energy metabolites middle cerebral artery occluded model in rats.
Topics: Adenosine Triphosphate; Animals; Aspartic Acid; Brain; Disease Models, Animal; Excitatory Amino Acid | 2012 |
Social vs. environmental stress models of depression from a behavioural and neurochemical approach.
Topics: Animals; Anxiety; Behavior, Animal; Brain Stem; Depression; Disease Models, Animal; Dopamine; gamma- | 2013 |
Antipsychotic and sedative effects of the leaf extract of Crassocephalum bauchiense (Hutch.) Milne-Redh (Asteraceae) in rodents.
Topics: Animals; Antipsychotic Agents; Apomorphine; Asteraceae; Behavior, Animal; Body Temperature; Brain; C | 2012 |
Gabapentin decreases epileptiform discharges in a chronic model of neocortical trauma.
Topics: Amines; Animals; Anticonvulsants; Blotting, Western; Brain Injuries; Cyclohexanecarboxylic Acids; Di | 2012 |
Painted turtle cortex is resistant to an in vitro mimic of the ischemic mammalian penumbra.
Topics: Action Potentials; Animals; Brain Ischemia; Cell Survival; Cerebral Cortex; Cerebrovascular Circulat | 2012 |
Pregabalin antinociception and its interaction with tramadol in acute model of pain.
Topics: Acute Pain; Analgesics; Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relations | 2012 |
Synergistic interaction of pregabalin with the synthetic cannabinoid WIN 55,212-2 mesylate in the hot-plate test in mice: an isobolographic analysis.
Topics: Acute Pain; Analgesics; Animals; Benzoxazines; Disease Models, Animal; Dose-Response Relationship, D | 2012 |
The antinociceptive effects of systemic administration of tramadol, gabapentin and their combination on mice model of acute pain.
Topics: Acute Pain; Amines; Analgesics; Analgesics, Opioid; Animals; Cyclohexanecarboxylic Acids; Disease Mo | 2012 |
Selective overexpression of Comt in prefrontal cortex rescues schizophrenia-like phenotypes in a mouse model of 22q11 deletion syndrome.
Topics: Animals; Benzodiazepinones; Catechol O-Methyltransferase; Chromatography, High Pressure Liquid; DiGe | 2012 |
ONO-2506 inhibits spike-wave discharges in a genetic animal model without affecting traditional convulsive tests via gliotransmission regulation.
Topics: Animals; Anticonvulsants; Astrocytes; Caprylates; Cells, Cultured; Convulsants; Disease Models, Anim | 2013 |
Collagen antibody-induced arthritis evokes persistent pain with spinal glial involvement and transient prostaglandin dependency.
Topics: Amines; Analgesics; Animals; Arthralgia; Arthritis, Experimental; Buprenorphine; Cyclohexanecarboxyl | 2012 |
Combined carbamazepine and pregabalin therapy in a rat model of neuropathic pain.
Topics: Analgesics; Animals; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug S | 2012 |
Altered neurochemical profile in the McGill-R-Thy1-APP rat model of Alzheimer's disease: a longitudinal in vivo 1 H MRS study.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Choline; Cre | 2012 |
Reduction of nitric oxide-mediated γ-amino butyric acid release in rostral ventrolateral medulla is involved in superoxide-induced sympathoexcitation of hypertensive rats.
Topics: Animals; Arterial Pressure; Bicuculline; Cyclic N-Oxides; Disease Models, Animal; Down-Regulation; E | 2012 |
The effect of gabapentin on oxidative stress in a model of toxic demyelination in rat brain.
Topics: Amines; Animals; Antioxidants; Cerebral Cortex; Cyclohexanecarboxylic Acids; Demyelinating Diseases; | 2012 |
Pre- and post-synaptic switches of GABA actions associated with Cl- homeostatic changes are induced in the spinal nucleus of the trigeminal nerve in a rat model of trigeminal neuropathic pain.
Topics: Animals; Chlorides; Disease Models, Animal; gamma-Aminobutyric Acid; HEK293 Cells; Homeostasis; Huma | 2013 |
Transplantation of GABAergic cells derived from bioreactor-expanded human neural precursor cells restores motor and cognitive behavioral deficits in a rodent model of Huntington's disease.
Topics: Animals; Behavior, Animal; Cell Transdifferentiation; Cells, Cultured; Disease Models, Animal; Femal | 2013 |
[Effect of acupuncture at different acupoints on expression of hypothalamic GABA and GABA(A) receptor proteins in insomnia rats].
Topics: Acupuncture Points; Acupuncture Therapy; Animals; Disease Models, Animal; gamma-Aminobutyric Acid; H | 2012 |
Molecular targeting of NOX4 for neuropathic pain after traumatic injury of the spinal cord.
Topics: Animals; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Humans; Mice; Mice, Inbred ICR; Mi | 2012 |
Diminished cortical inhibition in an aging mouse model of chronic tinnitus.
Topics: Acoustic Stimulation; Aging; Animals; Auditory Cortex; Auditory Threshold; Cerebral Cortex; Chronic | 2012 |
Effects of oxymatrine on the neuropathic pain induced by chronic constriction injury in mice.
Topics: Alkaloids; Animals; Chronic Disease; Constriction; Disease Models, Animal; Dose-Response Relationshi | 2012 |
Transient lack of glucose but not O2 is involved in ischemic postconditioning-induced neuroprotection.
Topics: Animals; Brain Infarction; Chromatography, High Pressure Liquid; Disease Models, Animal; gamma-Amino | 2013 |
Gabapentin reduces allodynia and hyperalgesia in painful diabetic neuropathy rats by decreasing expression level of Nav1.7 and p-ERK1/2 in DRG neurons.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Diabetic Neuropathies; Disease Models, Ani | 2013 |
Anticonvulsant effects by bilateral and unilateral transplantation of GABA-producing cells into the subthalamic nucleus in an acute seizure model.
Topics: Acute Disease; Animals; Brain Tissue Transplantation; Corpus Striatum; Disease Models, Animal; Femal | 2014 |
Decreased tonic inhibition in cerebellar granule cells causes motor dysfunction in a mouse model of Angelman syndrome.
Topics: Angelman Syndrome; Animals; Cerebellum; Disease Models, Animal; GABA Agonists; GABA Plasma Membrane | 2012 |
Relief of hypersensitivity after nerve injury from systemic donepezil involves spinal cholinergic and γ-aminobutyric acid mechanisms.
Topics: Animals; Atropine; Bicuculline; Cholinergic Agents; Cholinesterase Inhibitors; Disease Models, Anima | 2013 |
Blunted endogenous GABA-mediated inhibition in the hypothalamic paraventricular nucleus of rats with streptozotocin-induced diabetes.
Topics: Animals; Bicuculline; Blood Pressure; Diabetes Mellitus, Experimental; Disease Models, Animal; GABA- | 2013 |
Accumulation of GABAergic neurons, causing a focal ambient GABA gradient, and downregulation of KCC2 are induced during microgyrus formation in a mouse model of polymicrogyria.
Topics: Age Factors; Animals; Animals, Newborn; Bicuculline; Cell Count; Cerebral Cortex; Disease Models, An | 2014 |
Novel limonene and citral based 2,5-disubstituted-1,3,4-oxadiazoles: a natural product coupled approach to semicarbazones for antiepileptic activity.
Topics: Acyclic Monoterpenes; Animals; Anticonvulsants; Binding Sites; Cyclohexenes; Disease Models, Animal; | 2013 |
Antiepileptic drugs prevent changes in adenosine deamination during acute seizure episodes in adult zebrafish.
Topics: Adenine Nucleotides; Adenosine; Adenosine Deaminase; Amines; Animals; Anticonvulsants; Brain; Cycloh | 2013 |
Glycine receptor deficiency and its effect on the horizontal vestibulo-ocular reflex: a study on the SPD1J mouse.
Topics: Animals; Disease Models, Animal; Down-Regulation; Eye Movements; Female; gamma-Aminobutyric Acid; Gl | 2013 |
Intrathecal ketamine and pregabalin at sub-effective doses synergistically reduces neuropathic pain without motor dysfunction in mice.
Topics: Analgesics; Animals; Disease Models, Animal; Drug Synergism; gamma-Aminobutyric Acid; Hyperalgesia; | 2013 |
Upregulation of TrkB by forskolin facilitated survival of MSC and functional recovery of memory deficient model rats.
Topics: Adenylyl Cyclases; Animals; Brain-Derived Neurotrophic Factor; Cell Survival; Colforsin; Disease Mod | 2013 |
Piperine decreases pilocarpine-induced convulsions by GABAergic mechanisms.
Topics: Alkaloids; Amino Acids; Animals; Anticonvulsants; Antioxidants; Atropine; Benzodioxoles; Biogenic Mo | 2013 |
L-Theanine intake increases threshold for limbic seizures but decreases threshold for generalized seizures.
Topics: Animals; Disease Models, Animal; GABA Agents; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hi | 2013 |
Design and synthesis of some new quinazolin-4-(3H)-ones as anticonvulsant and antidepressant agents.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Brain; Disease Models, Animal; Drug Design; gamma-A | 2013 |
Prenatal immune activation induces maturation-dependent alterations in the prefrontal GABAergic transcriptome.
Topics: Age Factors; Animals; Behavior, Animal; Disease Models, Animal; Female; GABAergic Neurons; gamma-Ami | 2014 |
[Changes of glutamate and γ-aminobutyric acid of extracellular fluid in hippocampus during electrical stimulation of anterior nucleus thalamus in rats].
Topics: Animals; Anterior Thalamic Nuclei; Disease Models, Animal; Electric Stimulation; Epilepsy; Extracell | 2012 |
Combined antiallodynic effect of Neurotropin® and pregabalin in rats with L5-spinal nerve ligation.
Topics: Administration, Oral; Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; | 2013 |
Intrathecal gabapentin increases interleukin-10 expression and inhibits pro-inflammatory cytokine in a rat model of neuropathic pain.
Topics: Amines; Analgesics; Animals; Antibodies; Behavior, Animal; Cyclohexanecarboxylic Acids; Cytokines; D | 2013 |
Hormonally regulated alpha(4)beta(2)delta GABA(A) receptors are a target for alcohol.
Topics: Animals; Chlorides; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; Female; gamma | 2002 |
Changes in expression of voltage-dependent ion channel subunits in dorsal root ganglia of rats with radicular injury and pain.
Topics: Acetates; Amines; Analgesics; Animals; Behavior, Animal; Calcium Channels; Cyclohexanecarboxylic Aci | 2002 |
Axon sprouting in a model of temporal lobe epilepsy creates a predominantly excitatory feedback circuit.
Topics: Animals; Atropine Derivatives; Axons; Dendrites; Disease Models, Animal; Epilepsy, Temporal Lobe; Fe | 2002 |
Partial peripheral nerve injury promotes a selective loss of GABAergic inhibition in the superficial dorsal horn of the spinal cord.
Topics: Animals; Blotting, Western; Cell Death; Disease Models, Animal; Excitatory Postsynaptic Potentials; | 2002 |
GABA-opioid interactions in the globus pallidus: [D-Ala2]-Met-enkephalinamide attenuates potassium-evoked GABA release after nigrostriatal lesion.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Behavior, Animal; Cats; Disease Models, Anima | 2002 |
Heterotopic neurons with altered inhibitory synaptic function in an animal model of malformation-associated epilepsy.
Topics: Animals; Carrier Proteins; Choristoma; Disease Models, Animal; Epilepsy; Female; GABA Plasma Membran | 2002 |
Effect of gabapentin on the anticonvulsant activity of antiepileptic drugs against electroconvulsions in mice: an isobolographic analysis.
Topics: Acetates; Amines; Animals; Anticonvulsants; Behavior, Animal; Cyclohexanecarboxylic Acids; Disease M | 2002 |
Increased excitability and decreased sensitivity to GABA in an animal model of dysplastic cortex.
Topics: Animals; Bicuculline; Carmustine; Cerebral Cortex; Disease Models, Animal; Electric Stimulation; Ele | 2002 |
Amygdala kindling induces upregulation of mRNA for NKCC1, a Na(+), K(+)-2Cl(-) cotransporter, in the rat piriform cortex.
Topics: Amygdala; Animals; Chlorides; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Gene Expres | 2002 |
Subthalamic GAD gene therapy in a Parkinson's disease rat model.
Topics: Animals; Dependovirus; Disease Models, Animal; Dopamine; Electric Stimulation; Electrophysiology; ga | 2002 |
Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia.
Topics: Acetates; Adrenergic Uptake Inhibitors; Amines; Aminopyridines; Analgesia; Analgesics; Animals; Cell | 2002 |
Injury type-specific calcium channel alpha 2 delta-1 subunit up-regulation in rat neuropathic pain models correlates with antiallodynic effects of gabapentin.
Topics: Acetates; Amines; Animals; Calcium Channels; Cyclohexanecarboxylic Acids; Diabetic Neuropathies; Dis | 2002 |
Unaltered control of extracellular GABA-concentration through GAT-1 in the hippocampus of rats after pilocarpine-induced status epilepticus.
Topics: Animals; Disease Models, Animal; Extracellular Space; GABA Agonists; gamma-Aminobutyric Acid; Hippoc | 2003 |
Norepinephrine-gamma-aminobutyric acid (GABA) interaction in limbic stress circuits: effects of reboxetine on GABAergic neurons.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Depressive Disorder; Disease | 2003 |
Long-term potentiation is increased in the CA1 area of the hippocampus of APP(swe/ind) CRND8 mice.
Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Disease Models, Animal; Electroph | 2002 |
Compounds acting at the endocannabinoid and/or endovanilloid systems reduce hyperkinesia in a rat model of Huntington's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amino Acids, Neutral; Animals; Arachidonic Acids; Basal Ganglia; Can | 2003 |
A mouse model of episodic ataxia type-1.
Topics: Acetazolamide; Action Potentials; Animals; Carbonic Anhydrases; Cell Membrane; Cerebellum; Disease M | 2003 |
Astrocyte metabolism is disturbed in the early development of experimental hydrocephalus.
Topics: Acetates; Animals; Astrocytes; Biomarkers; Brain Stem; Carbon Isotopes; Disease Models, Animal; Dise | 2003 |
Nonhuman primate studies of fear, anxiety, and temperament and the role of benzodiazepine receptors and GABA systems.
Topics: Animals; Anxiety Disorders; Behavior, Animal; Disease Models, Animal; Fear; Frontal Lobe; Functional | 2003 |
Lower in vivo brain extracellular GABA concentration in diabetic rats during forced swimming.
Topics: Animals; Anti-Bacterial Agents; Behavior, Animal; Diabetes Mellitus; Disease Models, Animal; Extrace | 2003 |
Baclofen attenuates conditioned locomotion to cues associated with cocaine administration and stabilizes extracellular glutamate levels in rat nucleus accumbens.
Topics: Animals; Baclofen; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Cues; Disease Mo | 2003 |
Activation of a glycine transporter on spinal cord neurons causes enhanced glutamate release in a mouse model of amyotrophic lateral sclerosis.
Topics: Age Factors; Amino Acid Transport Systems, Neutral; Amyotrophic Lateral Sclerosis; Animals; D-Aspart | 2003 |
Down-regulation of GABA-transporter function by hippocampal translation products: its possible role in epilepsy.
Topics: Animals; Carrier Proteins; Disease Models, Animal; Down-Regulation; Epilepsy; Excitatory Amino Acid | 2003 |
GABA transmission in the nucleus accumbens is altered after withdrawal from repeated cocaine.
Topics: Animals; Binding, Competitive; Chronic Disease; Cocaine; Cocaine-Related Disorders; Disease Models, | 2003 |
Gabapentin blocks and reverses antinociceptive morphine tolerance in the rat paw-pressure and tail-flick tests.
Topics: Acetates; Amines; Analgesics, Opioid; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; | 2003 |
Effect of vigabatrin on contractile response to arachidonic acid and prostaglandins in smooth muscle preparations and platelet aggregation in experimental laboratory animals.
Topics: 4-Aminobutyrate Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta; Arachidonic A | 2003 |
Impaired modulation of GABAergic transmission by muscarinic receptors in a mouse transgenic model of Alzheimer's disease.
Topics: Action Potentials; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Carbachol; Disease Mo | 2003 |
Neurochemical characteristics of the ventromedial hypothalamus in mediating the antiaversive effects of anxiolytics in different models of anxiety.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Anti- | 2003 |
Basal ganglia efferents to the brainstem centers controlling postural muscle tone and locomotion: a new concept for understanding motor disorders in basal ganglia dysfunction.
Topics: Animals; Atropine; Basal Ganglia; Basal Ganglia Diseases; Bicuculline; Brain Stem; Cats; Choline O-A | 2003 |
Extracellular glutamate and other amino acids in experimental intracerebral hemorrhage: an in vivo microdialysis study.
Topics: Analysis of Variance; Animals; Asparagine; Aspartic Acid; Brain Ischemia; Cerebral Hemorrhage; Chrom | 2003 |
Is the interaction between felbamate and valproate against seizures induced by 4-aminopyridine and pentylenetetrazole in mice beneficial?
Topics: 4-Aminopyridine; Analysis of Variance; Animals; Brain; Chromatography, Liquid; Disease Models, Anima | 2003 |
Synchronization of kainate-induced epileptic activity via GABAergic inhibition in the superfused rat hippocampus in vivo.
Topics: Action Potentials; Animals; Diffusion Chambers, Culture; Disease Models, Animal; Electroencephalogra | 2003 |
Retinal remodeling triggered by photoreceptor degenerations.
Topics: Aging; Amino Acids; Animals; Animals, Genetically Modified; Cell Death; Cell Movement; Disease Model | 2003 |
Purification of a neuroprotective component of Parawixia bistriata spider venom that enhances glutamate uptake.
Topics: Animals; Brazil; Carbon Isotopes; Cerebral Cortex; Chromatography, High Pressure Liquid; Chromatogra | 2003 |
Gabapentin reverses mechanical allodynia induced by sciatic nerve ischemia and formalin-induced nociception in mice.
Topics: Acetates; Amines; Analgesics; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Disease Models | 2003 |
Group III metabotropic glutamate receptor-mediated modulation of the striatopallidal synapse.
Topics: Adrenergic Uptake Inhibitors; Aminobutyrates; Animals; Corpus Striatum; Disease Models, Animal; Elec | 2003 |
Expression of glutamate transporter, GABRA6, serine proteinase inhibitor 2 and low levels of glutamate and GABA in the brain of knock-out mouse for Canavan disease.
Topics: Amino Acid Transport System X-AG; Analysis of Variance; Animals; Azo Compounds; Brain Chemistry; Can | 2003 |
Downregulation of the alpha5 subunit of the GABA(A) receptor in the pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Down-Regulation; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; | 2003 |
Long-term plasticity of endocannabinoid signaling induced by developmental febrile seizures.
Topics: Action Potentials; Animals; Blotting, Western; Cannabinoid Receptor Modulators; Cells, Cultured; Chr | 2003 |
Germinated brown rice extract shows a nutraceutical effect in the recovery of chronic alcohol-related symptoms.
Topics: Alcohol Drinking; Amino Acids; Animals; Cholesterol, HDL; Disease Models, Animal; gamma-Aminobutyric | 2003 |
GABA, experimental myopia, and ocular growth in chick.
Topics: Animals; Chickens; Disease Models, Animal; Eye; GABA Agonists; GABA Antagonists; GABA-A Receptor Ago | 2003 |
Selective changes in gamma-aminobutyric acid type A receptor subunits in the hippocampus in spontaneously seizing rats with chronic temporal lobe epilepsy.
Topics: Animals; Chronic Disease; Disease Models, Animal; Epilepsy; Epilepsy, Temporal Lobe; gamma-Aminobuty | 2003 |
Salt and wounds: a new mechanism for neuropathic pain.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Glycine; Humans; K Cl- Cotransporters; Ner | 2003 |
The reinforcing properties of alcohol are mediated by GABA(A1) receptors in the ventral pallidum.
Topics: Alcoholism; Alcohols; Animals; Body Weight; Carbolines; Conditioning, Operant; Disease Models, Anima | 2003 |
Reduced inhibition and increased output of layer II neurons in the medial entorhinal cortex in a model of temporal lobe epilepsy.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Entorhinal Cortex; Epilepsy, Temporal Lobe; gamma-Am | 2003 |
In vitro formation of a secondary epileptogenic mirror focus by interhippocampal propagation of seizures.
Topics: Animals; Animals, Newborn; Chloride Channels; Disease Models, Animal; Epilepsy; Excitatory Amino Aci | 2003 |
Boosting GABA improves impaired auditory temporal resolution in the gerbil.
Topics: Acoustic Stimulation; Aging; Animals; Anticonvulsants; Auditory Pathways; Auditory Perceptual Disord | 2003 |
Lithium alters measures of auditory gating in two strains of mice.
Topics: Animals; Antipsychotic Agents; Auditory Perceptual Disorders; Cholinergic Fibers; Disease Models, An | 2003 |
Pharmacological characterisation of a rat model of incisional pain.
Topics: Amines; Analgesics; Animals; Behavior, Animal; Celecoxib; Cyclohexanecarboxylic Acids; Disease Model | 2004 |
Postoperative pain and analgesic responses are similar in male and female Sprague-Dawley rats.
Topics: Acetates; Amines; Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Cholinesterase Inhibito | 2003 |
Expression of plasma membrane GABA transporters but not of the vesicular GABA transporter in dentate granule cells after kainic acid seizures.
Topics: Animals; Carrier Proteins; Cell Membrane; Dentate Gyrus; Disease Models, Animal; Epilepsy; Epilepsy, | 2003 |
The neonatal ventral hippocampal lesion model of schizophrenia: effects on dopamine and GABA mRNA markers in the rat midbrain.
Topics: Aging; Animals; Animals, Newborn; Disease Models, Animal; Dopamine; Dopamine Plasma Membrane Transpo | 2003 |
entla, a novel epileptic and ataxic Cacna2d2 mutant of the mouse.
Topics: Acetates; Alleles; Amines; Animals; Ataxia; Base Sequence; Blotting, Southern; Blotting, Western; Ca | 2004 |
A nitric oxide (NO)-releasing derivative of gabapentin, NCX 8001, alleviates neuropathic pain-like behavior after spinal cord and peripheral nerve injury.
Topics: Acetates; Amines; Animals; Aorta, Thoracic; Behavior, Animal; Cyclic GMP; Cyclohexanecarboxylic Acid | 2004 |
Removal of GABAergic inhibition facilitates polysynaptic A fiber-mediated excitatory transmission to the superficial spinal dorsal horn.
Topics: Animals; Denervation; Disease Models, Animal; Excitatory Amino Acid Antagonists; Excitatory Postsyna | 2003 |
Structural involvement of the glutamatergic presynaptic boutons in a transgenic mouse model expressing early onset amyloid pathology.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cerebral Cortex; | 2003 |
Defining a metabolic phenotype in the brain of a transgenic mouse model of spinocerebellar ataxia 3.
Topics: Animals; Ataxin-3; Brain; Cerebellum; Choline; Disease Models, Animal; gamma-Aminobutyric Acid; Gluc | 2004 |
Transplants of cells engineered to produce GABA suppress spontaneous seizures.
Topics: Animals; Cell Culture Techniques; Cell Transplantation; Cerebral Cortex; Disease Models, Animal; gam | 2004 |
Ultrastructural organization of GABA-like immunoreactive profiles in the weaver substantia nigra.
Topics: Animals; Dendrites; Disease Models, Animal; Dopamine; Female; gamma-Aminobutyric Acid; Immunohistoch | 2003 |
Methamphetamine and AIDS: 1HMRS studies in a feline model of human disease.
Topics: Acquired Immunodeficiency Syndrome; Animals; Brain; Brain Chemistry; Cats; Choline; Creatine; Diseas | 2004 |
Neurotransmitter release in experimental stroke models: the role of glutamate-GABA interaction.
Topics: Action Potentials; Animals; Brain; D-Aspartic Acid; Disease Models, Animal; Excitatory Amino Acid An | 2004 |
Can lesions of GPe correct HD deficits?
Topics: Animals; Disease Models, Animal; Enkephalins; gamma-Aminobutyric Acid; Globus Pallidus; Humans; Hunt | 2004 |
Rapid deletion of mossy cells does not result in a hyperexcitable dentate gyrus: implications for epileptogenesis.
Topics: Dentate Gyrus; Disease Models, Animal; Electric Stimulation; Epilepsy, Temporal Lobe; Excitatory Pos | 2004 |
The anti-hyperalgesic activity of retigabine is mediated by KCNQ potassium channel activation.
Topics: Acute Disease; Amines; Analgesics, Opioid; Animals; Carbamates; Cyclohexanecarboxylic Acids; Disease | 2004 |
In vivo modulation of extracellular hippocampal glutamate and GABA levels and limbic seizures by group I and II metabotropic glutamate receptor ligands.
Topics: Amino Acids; Animals; Anticonvulsants; Benzoates; Bridged Bicyclo Compounds, Heterocyclic; Cycloprop | 2004 |
Painful neuropathy alters the effect of gabapentin on sensory neuron excitability in rats.
Topics: Acetates; Action Potentials; Amines; Analgesics; Analysis of Variance; Animals; Calcium Channels; Cy | 2004 |
Effects of the suppression of acute herpetic pain by gabapentin and amitriptyline on the incidence of delayed postherpetic pain in mice.
Topics: Acetates; Amines; Amitriptyline; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, A | 2004 |
Continuous intra-amygdalar infusion of GABA in the amygdala kindling model of epilepsy in rat.
Topics: Amygdala; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electr | 2004 |
Parvalbumin deficiency affects network properties resulting in increased susceptibility to epileptic seizures.
Topics: Action Potentials; Animals; Brain; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Geneti | 2004 |
Effect of gabapentin derivates on mechanical allodynia-like behaviour in a rat model of chronic sciatic constriction injury.
Topics: Amines; Animals; Chronic Disease; Cyclohexanecarboxylic Acids; Cyclohexanols; Disease Models, Animal | 2004 |
Antiepileptic drug treatment of nonconvulsive seizures induced by experimental focal brain ischemia.
Topics: Amines; Animals; Anticonvulsants; Brain Infarction; Brain Injuries; Brain Ischemia; Cyclohexanecarbo | 2004 |
Cataplexy-active neurons in the hypothalamus: implications for the role of histamine in sleep and waking behavior.
Topics: Action Potentials; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cataplexy; Dise | 2004 |
Mechanical allodynia following contusion injury of the rat spinal cord is associated with loss of GABAergic inhibition in the dorsal horn.
Topics: Action Potentials; Animals; Bicuculline; Disease Models, Animal; Electric Stimulation; Female; GABA | 2004 |
Modulation of the gait deficit in arthritic rats by infusions of muscimol and bicuculline.
Topics: Animals; Arthralgia; Arthritis, Experimental; Body Weight; Disease Models, Animal; Dose-Response Rel | 2004 |
Brain energy metabolism in a sub-acute rat model of manganese neurotoxicity: an ex vivo nuclear magnetic resonance study using [1-13C]glucose.
Topics: Animals; Blood Glucose; Brain; Carbon Isotopes; Disease Models, Animal; Energy Metabolism; gamma-Ami | 2004 |
The central piriform cortex: anatomical connections and anticonvulsant effect of GABA elevation in the kindling model.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Female; gamma-Aminobutyric Acid; Injecti | 2004 |
Regional and cellular neuropathology in the palmitoyl protein thioesterase-1 null mutant mouse model of infantile neuronal ceroid lipofuscinosis.
Topics: Animals; Astrocytes; Atrophy; Disease Models, Animal; Fluorescence; gamma-Aminobutyric Acid; Hippoca | 2004 |
Abnormal benzodiazepine and zinc modulation of GABAA receptors in an acquired absence epilepsy model.
Topics: Androstenes; Animals; Anticonvulsants; Benzodiazepines; Diazepam; Disease Models, Animal; Enzyme Inh | 2004 |
Adenosine A(2A) receptor-mediated modulation of GABA and glutamate release in the output regions of the basal ganglia in a rodent model of Parkinson's disease.
Topics: Adenosine A2 Receptor Antagonists; Animals; Basal Ganglia; Denervation; Disease Models, Animal; Effe | 2004 |
Epileptic-like convulsions associated with LIS-1 in the cytoskeletal control of neurotransmitter signaling in Caenorhabditis elegans.
Topics: Alleles; Amino Acid Sequence; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Codo | 2004 |
Efficacy of duloxetine, a potent and balanced serotonin-norepinephrine reuptake inhibitor in persistent pain models in rats.
Topics: Acute Disease; Amines; Amitriptyline; Animals; Conscious Sedation; Cyclohexanecarboxylic Acids; Cycl | 2004 |
Estrogen attenuates neuronal excitability in the insular cortex following middle cerebral artery occlusion.
Topics: Action Potentials; Animals; Cerebral Cortex; Disease Models, Animal; Down-Regulation; Estrogens; gam | 2004 |
Seizure evolution and amino acid imbalances in murine succinate semialdehyde dehydrogenase (SSADH) deficiency.
Topics: Aldehyde Oxidoreductases; Amino Acids; Animals; Brain; Disease Models, Animal; Epilepsy; gamma-Amino | 2004 |
Neurogenesis in the striatum of the quinolinic acid lesion model of Huntington's disease.
Topics: Animals; Biomarkers; Bromodeoxyuridine; Cell Death; Cell Differentiation; Cell Division; Cell Moveme | 2004 |
GABA neurons survive focal ischemic injury.
Topics: Animals; Brain Ischemia; Cell Survival; Cerebral Cortex; Disease Models, Animal; Down-Regulation; Fu | 2004 |
Future Pain Drugs - Europe 2003. 15-16 September 2003, London, UK.
Topics: Acetaminophen; Acetates; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, A | 2003 |
Differential analgesic sensitivity of two distinct neuropathic pain models.
Topics: Acetates; Amines; Analgesics; Analgesics, Opioid; Animals; Cold Temperature; Cyclohexanecarboxylic A | 2004 |
Pharmacological characterisation of the rat brachial plexus avulsion model of neuropathic pain.
Topics: Acetates; Amines; Analgesics; Analysis of Variance; Animals; Brachial Plexus; Brachial Plexus Neurop | 2004 |
The biology and pharmacology of calcium channel alpha2-delta proteins Pfizer Satellite Symposium to the 2003 Society for Neuroscience Meeting. Sheraton New Orleans Hotel, New Orleans, LA November 10, 2003.
Topics: Acetates; Amines; Analgesics; Animals; Anticonvulsants; Binding Sites; Calcium Channels; Calcium Cha | 2004 |
Gabapentin-lactam, but not gabapentin, reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington's disease.
Topics: Amines; Animals; Anticonvulsants; Aza Compounds; Corpus Striatum; Cyclohexanecarboxylic Acids; Disea | 2004 |
Binge ethanol exposure delays development of GABAergic miniature postsynaptic currents in septal neurons.
Topics: Alcohol-Induced Disorders, Nervous System; Animals; Cell Differentiation; Cells, Cultured; Central N | 2004 |
Gabapentin relieves mechanical, warm and cold allodynia in a rat model of peripheral neuropathy.
Topics: Amines; Animals; Cold Temperature; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Respons | 2004 |
Changes of pyridoxal kinase expression and activity in the gerbil hippocampus following transient forebrain ischemia.
Topics: Animals; Astrocytes; Disease Models, Animal; Down-Regulation; gamma-Aminobutyric Acid; Gerbillinae; | 2004 |
Synaptic transmission and synchronous activity is disrupted in hippocampal slices taken from aged TAS10 mice.
Topics: 4-Aminopyridine; Action Potentials; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cort | 2005 |
A mouse model for Finnish variant late infantile neuronal ceroid lipofuscinosis, CLN5, reveals neuropathology associated with early aging.
Topics: Aging; Animals; Base Sequence; Brain; Disease Models, Animal; DNA Primers; gamma-Aminobutyric Acid; | 2004 |
Suppressive effect of Saiko-ka-ryukotsu-borei-to, a herbal medicine, on excessive release of glutamate in the hippocampus.
Topics: Animals; Body Weight; Disease Models, Animal; Drugs, Chinese Herbal; Excitatory Amino Acid Antagonis | 2004 |
Induction of GABAergic phenotype in a neural stem cell line for transplantation in an excitotoxic model of Huntington's disease.
Topics: Animals; Cell Differentiation; Cell Line; Cell Proliferation; Cells, Cultured; Disease Models, Anima | 2004 |
Sensitivity of thalamic GABAergic currents to clonazepam does not differ between control and genetic absence epilepsy rats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Antic | 2004 |
Increased GABAergic function in mouse models of Huntington's disease: reversal by BDNF.
Topics: Animals; Brain-Derived Neurotrophic Factor; Disease Models, Animal; GABA Antagonists; gamma-Aminobut | 2004 |
Subregional changes in discharge rate, pattern, and drug sensitivity of putative GABAergic nigral neurons in the kindling model of epilepsy.
Topics: Action Potentials; Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Female; gamma-Aminobu | 2004 |
Spinal implantation of hNT neurons and neuronal precursors: graft survival and functional effects in rats with ischemic spastic paraplegia.
Topics: Animals; Animals, Newborn; Biomarkers; Cells, Cultured; Coculture Techniques; Disease Models, Animal | 2004 |
Neuronal nitric oxide synthase (nNOS) positive retinal amacrine cells are altered in the DBA/2NNia mouse, a murine model for angle-closure glaucoma.
Topics: Amacrine Cells; Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Glaucoma, Angle-Closure; I | 2004 |
Pharmacological and anatomical evidence for an interaction between mGluR5- and GABA(A) alpha1-containing receptors in the discriminative stimulus effects of ethanol.
Topics: Alcoholism; Animals; Diazepam; Discrimination, Psychological; Disease Models, Animal; Drug Interacti | 2005 |
Cefoselis, a beta-lactam antibiotic, easily penetrates the blood-brain barrier and causes seizure independently by glutamate release.
Topics: Animals; Anti-Bacterial Agents; Blood-Brain Barrier; Brain; Cefazolin; Ceftizoxime; Chromatography, | 2004 |
The GABA uptake inhibitor beta-alanine reduces pilocarpine-induced tremor and increases extracellular GABA in substantia nigra pars reticulata as measured by microdialysis.
Topics: Animals; beta-Alanine; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response R | 2004 |
Investigations of epilepsy with a mutant animal (EL mouse) model.
Topics: Animals; Brain; Disease Models, Animal; Electroencephalography; Epilepsy; gamma-Aminobutyric Acid; H | 2004 |
Potential involvement of cannabinoid receptors in 3-nitropropionic acid toxicity in vivo.
Topics: Animals; Autoradiography; Convulsants; Disease Models, Animal; Dopamine; Dronabinol; Drug Administra | 2004 |
Kinetics of glutamate and gamma-aminobutyric acid in cerebrospinal fluid in a canine model of complex partial status epilepticus induced by kainic acid.
Topics: Animals; Chromatography, High Pressure Liquid; Disease Models, Animal; Dogs; gamma-Aminobutyric Acid | 2004 |
Mice with Ppt1Deltaex4 mutation replicate the INCL phenotype and show an inflammation-associated loss of interneurons.
Topics: Animals; Animals, Newborn; Blindness, Cortical; Cell Death; Cerebral Cortex; Disease Models, Animal; | 2005 |
Evidence for a role of the parafascicular nucleus of the thalamus in the control of epileptic seizures by the superior colliculus.
Topics: Animals; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Excitatory Amino Acid Ag | 2005 |
Increased gabaergic input to ventral tegmental area dopaminergic neurons associated with decreased cocaine reinforcement in mu-opioid receptor knockout mice.
Topics: Afferent Pathways; Animals; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine; ga | 2005 |
Blockade of the membranal GABA transporter potentiates GABAergic responses evoked in pyramidal cells by mossy fiber activation after seizures.
Topics: Animals; Calcium Signaling; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Anta | 2005 |
Circling behavior and [14C]2-deoxyglucose mapping in rats: possible implications for autistic repetitive behaviors.
Topics: Aging; Animals; Autistic Disorder; Autoradiography; Behavior, Animal; Brain; Brain Mapping; Carbon R | 2005 |
Oral treatment with PD-0200347, an alpha2delta ligand, reduces the development of experimental osteoarthritis by inhibiting metalloproteinases and inducible nitric oxide synthase gene expression and synthesis in cartilage chondrocytes.
Topics: Administration, Oral; Amines; Animals; Cartilage, Articular; Chondrocytes; Cyclohexanecarboxylic Aci | 2005 |
GABA transporter currents activated by protein kinase A excite midbrain neurons during opioid withdrawal.
Topics: Action Potentials; Adaptation, Physiological; Animals; Chloride Channels; Cyclic AMP-Dependent Prote | 2005 |
Comparison of the antinociceptive profiles of gabapentin and 3-methylgabapentin in rat models of acute and persistent pain: implications for mechanism of action.
Topics: Acetates; Acute Disease; Amines; Analgesics; Animals; Benzylamines; Chronic Disease; Cyclohexanecarb | 2005 |
Disease-related regressive alterations of forebrain cholinergic system in SOD1 mutant transgenic mice.
Topics: Acetylcholine; Amyotrophic Lateral Sclerosis; Animals; Basal Nucleus of Meynert; Brain Stem; Cerebra | 2005 |
In vitro 1H NMR spectroscopy shows an increase in N-acetylaspartylglutamate and glutamine content in the hippocampus of amygdaloid-kindled rats.
Topics: Amino Acids; Amygdala; Animals; Creatine; Dipeptides; Disease Models, Animal; Energy Metabolism; Epi | 2005 |
Electrophysiological properties of cultured hippocampal neurons from Wistar Audiogenic Rats.
Topics: Action Potentials; Animals; Animals, Newborn; Cell Membrane; Cells, Cultured; Disease Models, Animal | 2005 |
Behavioral and neurochemical repercussions of hippocampal network activity blockade during the neonatal period.
Topics: Animals; Animals, Newborn; Behavior, Animal; Body Weight; Disease Models, Animal; Dopamine; Female; | 2005 |
Brain creatine functions to attenuate acute stress responses through GABAnergic system in chicks.
Topics: Acute Disease; Adaptation, Physiological; Animals; Brain; Brain Chemistry; Chickens; Creatine; Disea | 2005 |
Antiepileptic action induced by a combination of vigabatrin and tiagabine.
Topics: Action Potentials; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Dru | 2005 |
Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy.
Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anxiety; Ataxia; Behavior, Ani | 2005 |
Study of antiepileptic effect of extracts from Acorus tatarinowii Schott.
Topics: Acorus; Animals; Anticonvulsants; Brain; Disease Models, Animal; Electroshock; Epilepsy; gamma-Amino | 2005 |
Actions at GABA(A) receptors in the hippocampus may mediate some antiseizure effects of progestins.
Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Chlorides; Disease Mo | 2005 |
Effect of systemic and intrathecal gabapentin on allodynia in a new rat model of postherpetic neuralgia.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Diterpenes; Gabape | 2005 |
Effects of amitriptyline and gabapentin on bilateral hyperalgesia observed in an animal model of unilateral axotomy.
Topics: Amines; Amitriptyline; Animals; Anticonvulsants; Antidepressive Agents; Axotomy; Cyclohexanecarboxyl | 2005 |
Behavioral, pharmacological and molecular characterization of the saphenous nerve partial ligation: a new model of neuropathic pain.
Topics: Amines; Amitriptyline; Analgesics; Animals; Behavior, Animal; Benzoxazines; Blotting, Western; Cyclo | 2005 |
GABAA receptor beta3 subunit gene-deficient heterozygous mice show parent-of-origin and gender-related differences in beta3 subunit levels, EEG, and behavior.
Topics: Angelman Syndrome; Animals; Anticonvulsants; Brain; Brain Chemistry; Disease Models, Animal; Down-Re | 2005 |
Expression of GAD65 and GAD67 immunoreactivity in MPTP-treated monkeys with or without L-DOPA administration.
Topics: Animals; Basal Ganglia; Cell Count; Cerebral Cortex; Disease Models, Animal; Dopamine Agents; gamma- | 2005 |
Effects of phencyclidine on schedule-controlled responding following neurotoxic lesions of the striatum.
Topics: Animals; Conditioning, Operant; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Rel | 2005 |
Synergistic interaction of gabapentin and oxcarbazepine in the mouse maximal electroshock seizure model--an isobolographic analysis.
Topics: Amines; Animals; Anticonvulsants; Brain; Carbamazepine; Cyclohexanecarboxylic Acids; Disease Models, | 2005 |
Intravenous administration of human neural stem cells induces functional recovery in Huntington's disease rat model.
Topics: Animals; Apomorphine; Behavior, Animal; Cell Count; Cells, Cultured; Corpus Striatum; Disease Models | 2005 |
Gene transfer of glutamic acid decarboxylase reduces neuropathic pain.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Gene Transfer Techniques; Genetic Therapy; | 2005 |
Failure of ischemic neuroprotection by potentiators of gamma-aminobutyric acid.
Topics: Animals; Anticonvulsants; Brain Ischemia; Disease Models, Animal; Fructose; gamma-Aminobutyric Acid; | 2003 |
Decreased expression of vesicular GABA transporter, but not vesicular glutamate, acetylcholine and monoamine transporters in rat brain following focal ischemia.
Topics: Animals; Brain; Brain Ischemia; Cerebral Cortex; Disease Models, Animal; Down-Regulation; gamma-Amin | 2005 |
Target-specific catecholamine elevation induced by anticonvulsant thalamic deep brain stimulation.
Topics: Animals; Brain; Catecholamines; Chromatography, High Pressure Liquid; Deep Brain Stimulation; Diseas | 2005 |
Carboxylate bioisosteres of gabapentin.
Topics: Amines; Animals; Anticonvulsants; Carboxylic Acids; Cyclohexanecarboxylic Acids; Disease Models, Ani | 2006 |
Substance P inhibits progesterone conversion to neuroactive metabolites in spinal sensory circuit: a potential component of nociception.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Male; Models, Neurological; Neurons, Affer | 2005 |
Depressed responses to applied and synaptically-released GABA in CA1 pyramidal cells, but not in CA1 interneurons, after transient forebrain ischemia.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Gramicidin; Hippocampus; Interneurons; Isc | 2006 |
Arvanil, a hybrid endocannabinoid and vanilloid compound, behaves as an antihyperkinetic agent in a rat model of Huntington's disease.
Topics: Animals; Brain Chemistry; Capsaicin; Convulsants; Disease Models, Animal; Dopamine; gamma-Aminobutyr | 2005 |
Differential adaptations in GABAergic and glutamatergic systems during ethanol withdrawal in male and female rats.
Topics: Alcoholism; Amino Acid Transport System X-AG; Animals; Cerebral Cortex; Disease Models, Animal; Etha | 2005 |
Effects of ryanodine receptor activation on neurotransmitter release and neuronal cell death following kainic acid-induced status epilepticus.
Topics: Animals; Calcium; Cell Death; Chromatography, High Pressure Liquid; Disease Models, Animal; DNA, Sin | 2005 |
Developmental program of epileptogenesis in the brain of EL mice.
Topics: Animals; Apoptosis; Brain; Brain-Derived Neurotrophic Factor; Disease Models, Animal; DNA Fragmentat | 2005 |
The role of extracellular potassium in the epileptogenic transformation of recurrent GABAergic inhibition.
Topics: Animals; Calcium; Disease Models, Animal; Electric Stimulation; Epilepsy; Evoked Potentials; Extrace | 2005 |
GABA synapses and the rapid loss of inhibition to dentate gyrus granule cells after brief perforant-path stimulation.
Topics: Animals; Bicuculline; Dentate Gyrus; Disease Models, Animal; Electric Stimulation; GABA Antagonists; | 2005 |
Anticonvulsant action of GABA in the high potassium-low magnesium model of ictogenesis in the neonatal rat hippocampus in vivo and in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Bicucu | 2005 |
UCM707, an inhibitor of the anandamide uptake, behaves as a symptom control agent in models of Huntington's disease and multiple sclerosis, but fails to delay/arrest the progression of different motor-related disorders.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Arachidonic Acids; Brain Chemistry; D | 2006 |
Gamma-aminobutyric acid and mefloquine-induced seizures in mice.
Topics: Acetanilides; Aminooxyacetic Acid; Animals; Anti-Anxiety Agents; Chi-Square Distribution; Disease Mo | 2005 |
Brain genomics of intracerebral hemorrhage.
Topics: Animals; Annexin A1; Brain; Cerebral Hemorrhage; Cluster Analysis; Disease Models, Animal; Down-Regu | 2006 |
Design, synthesis, and preliminary evaluation of gabapentin-pregabalin mutual prodrugs in relieving neuropathic pain.
Topics: Amines; Analgesics, Non-Narcotic; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Drug | 2005 |
Temporal patterns of fos expression in the dentate gyrus after spontaneous seizures in a mouse model of temporal lobe epilepsy.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Hi | 2005 |
Heteroaromatic side-chain analogs of pregabalin.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; gamma-A | 2006 |
Excitotoxic brain damage involves early peroxynitrite formation in a model of Huntington's disease in rats: protective role of iron porphyrinate 5,10,15,20-tetrakis (4-sulfonatophenyl)porphyrinate iron (III).
Topics: Analysis of Variance; Animals; Behavior, Animal; Blotting, Southern; Brain Injuries; Caspase 3; Casp | 2005 |
Reelin and glutamic acid decarboxylase67 promoter remodeling in an epigenetic methionine-induced mouse model of schizophrenia.
Topics: Animals; Cell Adhesion Molecules, Neuronal; Chromatin Assembly and Disassembly; Chromosomal Proteins | 2005 |
The effect of experimental glaucoma and optic nerve transection on amacrine cells in the rat retina.
Topics: Amacrine Cells; Animals; Axons; Cell Count; Disease Models, Animal; gamma-Aminobutyric Acid; Glaucom | 2005 |
Regulation of synaptic plasticity in a schizophrenia model.
Topics: Animals; Disease Models, Animal; Electrophysiology; gamma-Aminobutyric Acid; Hippocampus; Male; Neur | 2005 |
Anti-nociception is selectively enhanced by parallel inhibition of multiple subtypes of monoamine transporters in rat models of persistent and neuropathic pain.
Topics: Amines; Analgesics; Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Bupropio | 2005 |
Isobolographic characterisation of interactions among selected newer antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model.
Topics: Amines; Animals; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Disease Models, Animal | 2005 |
Spinal-supraspinal serotonergic circuits regulating neuropathic pain and its treatment with gabapentin.
Topics: Action Potentials; Amines; Analgesics; Analysis of Variance; Animals; Behavior, Animal; Cell Count; | 2005 |
Mining the mouse mutant goldmine for sleep phenotypes.
Topics: Animals; ARNTL Transcription Factors; Basic Helix-Loop-Helix Transcription Factors; Brain; Disease M | 2005 |
Acute gamma-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-P | 2005 |
Effects of prenatal paraquat and mancozeb exposure on amino acid synaptic transmission in developing mouse cerebellar cortex.
Topics: Animals; Aspartic Acid; Cerebellar Cortex; Disease Models, Animal; Down-Regulation; Female; Fungicid | 2005 |
Disruption of interneuron development.
Topics: Animals; Autistic Disorder; Behavior, Animal; Cell Division; Cell Movement; Cerebral Cortex; Disease | 2005 |
Rearranging receptors.
Topics: Animals; Brain; Cerebellum; Child, Preschool; Disease Models, Animal; Disease Susceptibility; Epilep | 2005 |
Varicella zoster virus induces neuropathic changes in rat dorsal root ganglia and behavioral reflex sensitisation that is attenuated by gabapentin or sodium channel blocking drugs.
Topics: Amines; Animals; Anticonvulsants; Behavior, Animal; Cyclohexanecarboxylic Acids; Disease Models, Ani | 2005 |
High resolution 1H NMR-based metabolomics indicates a neurotransmitter cycling deficit in cerebral tissue from a mouse model of Batten disease.
Topics: Aging; Animals; Aspartic Acid; Brain; Cerebellum; Cerebral Cortex; Creatine; Disease Models, Animal; | 2005 |
Ischemic preconditioning ameliorates excitotoxicity by shifting glutamate/gamma-aminobutyric acid release and biosynthesis.
Topics: Animals; Brain Ischemia; Cell Death; Disease Models, Animal; Extracellular Fluid; GABA Agonists; gam | 2005 |
PD-0200347, an alpha2delta ligand of the voltage gated calcium channel, inhibits in vivo activation of the Erk1/2 pathway in osteoarthritic chondrocytes: a PKCalpha dependent effect.
Topics: Animals; Calcium Channels; Chondrocytes; CREB-Binding Protein; Disease Models, Animal; Dogs; Dose-Re | 2006 |
Multiple and plastic receptors mediate tonic GABAA receptor currents in the hippocampus.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Drug Interactions; Epilepsy; GABA Agents; GABA An | 2005 |
Antioxidant-like protein 1 is altered in non-pyramidal cells and expressed in astrocytes in the gerbil hippocampal CA1 region after transient forebrain ischemia.
Topics: Animals; Astrocytes; Blotting, Western; Disease Models, Animal; gamma-Aminobutyric Acid; Gerbillinae | 2005 |
The effects of diacerhein on mechanical allodynia in inflammatory and neuropathic models of nociception in mice.
Topics: Amines; Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Cyclohexanecarboxylic Acid | 2005 |
Differential pharmacological modulation of the spontaneous stimulus-independent activity in the rat spinal cord following peripheral nerve injury.
Topics: Action Potentials; Amines; Analgesics; Animals; Anticonvulsants; Behavior, Animal; Cyclohexanecarbox | 2006 |
Activity profile of pregabalin in rodent models of epilepsy and ataxia.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug | 2006 |
Neuroprotective effect of taurine in 3-nitropropionic acid-induced experimental animal model of Huntington's disease phenotype.
Topics: Animals; Corpus Striatum; Disease Models, Animal; gamma-Aminobutyric Acid; Huntington Disease; Male; | 2005 |
Altered inhibition in lateral amygdala networks in a rat model of temporal lobe epilepsy.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Amygdala; Animals; Disease Models, Animal; | 2006 |
Effects of rimonabant, a selective cannabinoid CB1 receptor antagonist, in a rat model of Parkinson's disease.
Topics: Adrenergic Agents; Analysis of Variance; Animals; Autoradiography; Brain; Brain Chemistry; Chromatog | 2006 |
2,4-Dimethoxyphenylsemicarbazones with anticonvulsant activity against three animal models of seizures: synthesis and pharmacological evaluation.
Topics: Animals; Anticonvulsants; Central Nervous System; Disease Models, Animal; gamma-Aminobutyric Acid; M | 2006 |
Spinal nerve ligation does not alter the expression or function of GABA(B) receptors in spinal cord and dorsal root ganglia of the rat.
Topics: Animals; Baclofen; Denervation; Disease Models, Animal; GABA Agonists; gamma-Aminobutyric Acid; Gang | 2006 |
Diphenyl diselenide and 2,3-dimercaptopropanol increase the PTZ-induced chemical seizure and mortality in mice.
Topics: Animals; Benzene Derivatives; Brain; Chelating Agents; Convulsants; Dimercaprol; Disease Models, Ani | 2006 |
Glutathione deficit during development induces anomalies in the rat anterior cingulate GABAergic neurons: Relevance to schizophrenia.
Topics: Animals; Brain Chemistry; Calbindin 2; Calbindins; Disease Models, Animal; Dopamine; Extracellular F | 2006 |
Beta and gamma range EEG power-spectrum correlation with spiking discharges in DBA/2J mice absence model: role of GABA receptors.
Topics: Alpha Rhythm; Animals; Baclofen; Beta Rhythm; Cerebral Cortex; Cognition; Cortical Synchronization; | 2006 |
The effects of ethosuximide on amino acids in genetic absence epilepsy rat model.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Ethosux | 2006 |
Distribution of GABAergic neurons in the striatum of amygdala-kindled rats: an immunohistochemical and in situ hybridization study.
Topics: Amygdala; Animals; Corpus Striatum; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; gamma-A | 2006 |
Manganese-induced neurotoxicity: the role of astroglial-derived nitric oxide in striatal interneuron degeneration.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Astrocytes; Brain; Disease Models, Animal; Dopamine; Female | 2006 |
Hyperdopaminergia and altered locomotor activity in GABAB1-deficient mice.
Topics: Animals; Binding Sites; Brain Diseases, Metabolic; Corpus Striatum; Disease Models, Animal; Dopamine | 2006 |
NAAG peptidase inhibitor increases dialysate NAAG and reduces glutamate, aspartate and GABA levels in the dorsal hippocampus following fluid percussion injury in the rat.
Topics: Animals; Aspartic Acid; Brain Injuries; Cytoprotection; Dipeptides; Disease Models, Animal; Down-Reg | 2006 |
Stable expression of the vesicular GABA transporter following photothrombotic infarct in rat brain.
Topics: Animals; Brain; Brain Infarction; Cerebral Cortex; Disease Models, Animal; Exocytosis; gamma-Aminobu | 2006 |
Carboxylate bioisosteres of pregabalin.
Topics: Amines; Animals; Anticonvulsants; Binding Sites; Carboxylic Acids; Cyclohexanecarboxylic Acids; Dise | 2006 |
Hyperexcitability, interneurons, and loss of GABAergic synapses in entorhinal cortex in a model of temporal lobe epilepsy.
Topics: Action Potentials; Animals; Cells, Cultured; Disease Models, Animal; Entorhinal Cortex; Epilepsy, Te | 2006 |
Succinic semialdehyde dehydrogenase deficiency: GABAB receptor-mediated function.
Topics: Animals; Binding Sites; Brain; Brain Chemistry; Brain Diseases, Metabolic, Inborn; Disease Models, A | 2006 |
Stiripentol, a putative antiepileptic drug, enhances the duration of opening of GABA-A receptor channels.
Topics: Animals; Animals, Newborn; Anticonvulsants; Chloride Channels; Dioxolanes; Disease Models, Animal; D | 2006 |
Dopamine changes in a rat model of intracerebral hemorrhage.
Topics: Adaptation, Physiological; Animals; Cerebral Hemorrhage; Corpus Striatum; Disease Models, Animal; Do | 2006 |
Neural stem cells may be uniquely suited for combined gene therapy and cell replacement: Evidence from engraftment of Neurotrophin-3-expressing stem cells in hypoxic-ischemic brain injury.
Topics: Acetylcholine; Animals; Animals, Newborn; beta-Galactosidase; Disease Models, Animal; gamma-Aminobut | 2006 |
Experimental studies and theoretical aspects on A2A/D2 receptor interactions in a model of Parkinson's disease. Relevance for L-dopa induced dyskinesias.
Topics: Adenosine; Adenosine A2 Receptor Antagonists; Adrenergic Agents; Animals; Chromatography, High Press | 2006 |
Surgically induced osteoarthritis in the rat results in the development of both osteoarthritis-like joint pain and secondary hyperalgesia.
Topics: Amines; Analgesics; Animals; Arthralgia; Cyclohexanecarboxylic Acids; Cyclooxygenase 2 Inhibitors; D | 2006 |
Acute changes in the neuronal expression of GABA and glutamate decarboxylase isoforms in the rat piriform cortex following status epilepticus.
Topics: Analysis of Variance; Animals; Cell Count; Disease Models, Animal; Female; gamma-Aminobutyric Acid; | 2006 |
Microanatomy in 21 day rat brains exposed prenatally to cocaine.
Topics: Animals; Brain; Cell Differentiation; Cocaine; Cocaine-Related Disorders; Dendrites; Disease Models, | 2006 |
Adult human bone marrow stromal spheres express neuronal traits in vitro and in a rat model of Parkinson's disease.
Topics: Animals; Biomarkers; Bone Marrow Transplantation; Cell Death; Cell Differentiation; Cell Line; Cells | 2006 |
Anxiolytic properties of green tea polyphenol (-)-epigallocatechin gallate (EGCG).
Topics: Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Behavior, Animal; Carbolines; Catechin; C | 2006 |
Nicotine-induced enhancement of synaptic plasticity at CA3-CA1 synapses requires GABAergic interneurons in adult anti-NGF mice.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Excitatory Postsynaptic Potentials; Female; gamm | 2006 |
Subiculum network excitability is increased in a rodent model of temporal lobe epilepsy.
Topics: Action Potentials; Animals; Biomarkers; Convulsants; Disease Models, Animal; Electric Stimulation; E | 2006 |
Role of the 5-HT2C receptor in improving weight-supported stepping in adult rats spinalized as neonates.
Topics: Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Disease Models, Animal; Dose-Resp | 2006 |
GABA(A) receptor mediated transmission in the thalamic reticular nucleus of rats with genetic absence epilepsy shows regional differences: functional implications.
Topics: Action Potentials; Afferent Pathways; Animals; Basal Ganglia; Bicuculline; Cerebral Cortex; Disease | 2006 |
The selective effects of somatostatin- and GABA-mediated transmissions on voltage gated Ca2+ channel immunoreactivity in the gerbil hippocampus.
Topics: Animals; Calcium Channels; Calcium Channels, L-Type; Calcium Channels, N-Type; Calcium Channels, P-T | 2006 |
Impaired formalin-evoked changes of spinal amino acid levels in diabetic rats.
Topics: Afferent Pathways; Amino Acids; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dis | 2006 |
Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy.
Topics: Action Potentials; Animals; Cell Line; Disease Models, Animal; Electroencephalography; Epilepsies, M | 2006 |
Examination of the interaction between peripheral diclofenac and gabapentin on the 5% formalin test in rats.
Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclohexanecarboxylic Acids; D | 2006 |
Differential paired-pulse responses between the CA1 region and the dentate gyrus are related to altered CLC-2 immunoreactivity in the pilocarpine-induced rat epilepsy model.
Topics: Action Potentials; Animals; Chloride Channels; CLC-2 Chloride Channels; Convulsants; Dentate Gyrus; | 2006 |
Septal GABAergic neurons are selectively vulnerable to pilocarpine-induced status epilepticus and chronic spontaneous seizures.
Topics: Analysis of Variance; Animals; Cell Survival; Disease Models, Animal; Fluoresceins; gamma-Aminobutyr | 2006 |
Inhibition of pain behavior by GABA(B) receptors in the thalamic ventrobasal complex: effect on normal rats subjected to the formalin test of nociception.
Topics: Acute Disease; Analgesics; Animals; Baclofen; Behavior, Animal; Chronic Disease; Disease Models, Ani | 2006 |
Gabapentin enhances the analgesic response to morphine in acute model of pain in male rats.
Topics: Amines; Analgesics, Opioid; Animals; Area Under Curve; Cyclohexanecarboxylic Acids; Disease Models, | 2006 |
Substantia nigra is an anticonvulsant site of action of topiramate in the focal pilocarpine model of limbic seizures.
Topics: Animals; Anticonvulsants; Area Under Curve; Behavior, Animal; Disease Models, Animal; Dose-Response | 2006 |
Differential effects of chronic amphetamine and baclofen administration on cAMP levels and phosphorylation of CREB in distinct brain regions of wild type and monoamine oxidase B-deficient mice.
Topics: Amphetamine; Amphetamine-Related Disorders; Animals; Baclofen; Biogenic Monoamines; Brain; Central N | 2006 |
Acute injury to superficial cortex leads to a decrease in synaptic inhibition and increase in excitation in neocortical layer V pyramidal cells.
Topics: Acute Disease; Animals; Brain Injuries; Disease Models, Animal; Epilepsy; Excitatory Postsynaptic Po | 2007 |
Design and synthesis of anticonvulsants from a combined phthalimide-GABA-anilide and hydrazone pharmacophore.
Topics: Anilides; Animals; Anticonvulsants; Disease Models, Animal; gamma-Aminobutyric Acid; Hydrazones; Mal | 2007 |
Chemotherapy-evoked painful peripheral neuropathy: analgesic effects of gabapentin and effects on expression of the alpha-2-delta type-1 calcium channel subunit.
Topics: Amines; Analgesics; Animals; Antineoplastic Agents, Phytogenic; Blotting, Western; Calcium Channels; | 2007 |
Ts65Dn, a mouse model of Down syndrome, exhibits increased GABAB-induced potassium current.
Topics: Animals; Animals, Newborn; Baclofen; Brain; Cell Membrane; Cells, Cultured; Disease Models, Animal; | 2007 |
Opposite effects of a GABA(B) antagonist in two models of epileptic seizures in developing rats.
Topics: Action Potentials; Aging; Animals; Animals, Newborn; Cerebral Cortex; Convulsants; Disease Models, A | 2006 |
GABA(B2) receptor subunit mRNA decreases in the thalamus of monoarthritic animals.
Topics: Afferent Pathways; Animals; Arthralgia; Arthritis; Chronic Disease; Disease Models, Animal; Down-Reg | 2006 |
Co-modulation of acute ethanol-induced motor impairment by mouse cerebellar adenosinergic A1 and GABA(A) receptor systems.
Topics: Acute Disease; Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Alcohol | 2006 |
Vagus nerve stimulation may protect GABAergic neurons following traumatic brain injury in rats: An immunocytochemical study.
Topics: Animals; Brain Injuries; Cell Count; Disease Models, Animal; Electric Stimulation; gamma-Aminobutyri | 2007 |
Seizures and enhanced cortical GABAergic inhibition in two mouse models of human autosomal dominant nocturnal frontal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Electrophysiology; Epilepsy, Frontal Lobe; gamma-Aminobutyric Acid; | 2006 |
Persistently decreased basal synaptic inhibition of hippocampal CA1 pyramidal neurons after neonatal hypoxia-induced seizures.
Topics: Animals; Animals, Newborn; Asphyxia Neonatorum; Disease Models, Animal; Down-Regulation; Epilepsy; g | 2007 |
Gabrb3 gene deficient mice exhibit increased risk assessment behavior, hypotonia and expansion of the plexus of locus coeruleus dendrites.
Topics: Animals; Anxiety Disorders; Behavior, Animal; Dendrites; Disease Models, Animal; Female; gamma-Amino | 2007 |
Alteration in the GABAergic network of the prefrontal cortex in a potential animal model of psychosis.
Topics: Aging; Animals; Cell Differentiation; Disease Models, Animal; Dopamine Uptake Inhibitors; Environmen | 2007 |
Further characterization of a rat model of varicella zoster virus-associated pain: Relationship between mechanical hypersensitivity and anxiety-related behavior, and the influence of analgesic drugs.
Topics: Amines; Analgesics; Animals; Anti-Anxiety Agents; Anxiety Disorders; Cells, Cultured; Cyclohexanecar | 2007 |
Accumbens neurochemical adaptations produced by binge-like alcohol consumption.
Topics: Alcohol Drinking; Alcoholism; Animals; Central Nervous System Depressants; Disease Models, Animal; D | 2007 |
A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain.
Topics: Amines; Analgesics; Animals; Anticonvulsants; Cold Temperature; Cyclohexanecarboxylic Acids; Disease | 2007 |
Hibernation model of tau phosphorylation in hamsters: selective vulnerability of cholinergic basal forebrain neurons - implications for Alzheimer's disease.
Topics: Acetylcholine; Alzheimer Disease; Animals; Blotting, Western; Calcium-Binding Proteins; Choline O-Ac | 2007 |
Absence seizures are reduced by the enhancement of GABA-ergic inhibition in the hippocampus in WAG/Rij rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Epi | 2007 |
Pregabalin reduces muscle and cutaneous hyperalgesia in two models of chronic muscle pain in rats.
Topics: Analgesics; Animals; Carrageenan; Chronic Disease; Disease Models, Animal; Dose-Response Relationshi | 2007 |
Shunting and hyperpolarizing GABAergic inhibition in the high-potassium model of ictogenesis in the developing rat hippocampus.
Topics: Aging; Animals; Animals, Newborn; Disease Models, Animal; Epilepsy; GABA Agonists; GABA Antagonists; | 2007 |
Enzymatic and metabolic evidence for a region specific mitochondrial dysfunction in brains of murine succinic semialdehyde dehydrogenase deficiency (Aldh5a1-/- mice).
Topics: Animals; Brain; Brain Diseases, Metabolic, Inborn; Citric Acid Cycle; Disease Models, Animal; Electr | 2007 |
Antiallodynic effect of pregabalin in rat models of sympathetically maintained and sympathetic independent neuropathic pain.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; gamma-Aminobutyric Ac | 2007 |
Sub-chronic psychotomimetic phencyclidine induces deficits in reversal learning and alterations in parvalbumin-immunoreactive expression in the rat.
Topics: Animals; Behavior, Animal; Cognition Disorders; Conditioning, Operant; Dentate Gyrus; Disease Models | 2007 |
Prenatal exposure to an NMDA receptor antagonist, MK-801 reduces density of parvalbumin-immunoreactive GABAergic neurons in the medial prefrontal cortex and enhances phencyclidine-induced hyperlocomotion but not behavioral sensitization to methamphetamine
Topics: Age Factors; Animals; Behavior, Animal; Central Nervous System Stimulants; Disease Models, Animal; D | 2007 |
Synaptic responses in superficial layers of medial entorhinal cortex from rats with kainate-induced epilepsy.
Topics: Animals; Convulsants; Disease Models, Animal; Electric Stimulation; Entorhinal Cortex; Epilepsy; Exc | 2007 |
Antagonism of metabotropic glutamate receptor type 5 attenuates l-DOPA-induced dyskinesia and its molecular and neurochemical correlates in a rat model of Parkinson's disease.
Topics: Animals; Antiparkinson Agents; Brain; Disease Models, Animal; Drug Interactions; Dyskinesia, Drug-In | 2007 |
Intraventricular administration of gabapentin in the rat increases flurothyl seizure threshold.
Topics: Amines; Animals; Anticonvulsants; Brain; Brain Chemistry; Cerebral Cortex; Convulsants; Cyclohexanec | 2007 |
Transgenic mice over-expressing GABA(B)R1a receptors acquire an atypical absence epilepsy-like phenotype.
Topics: Action Potentials; Animals; Behavior, Animal; Brain; Brain Chemistry; Disease Models, Animal; Epilep | 2007 |
The neuronal pathology of schizophrenia: molecules and mechanisms.
Topics: Animals; Aspartic Acid; Brain; Corpus Striatum; Disease Models, Animal; gamma-Aminobutyric Acid; Glu | 2007 |
Alterations in GABA(A) receptor expression in neonatal ventral hippocampal lesioned rats: comparison of prepubertal and postpubertal periods.
Topics: Adaptation, Physiological; Aging; Animals; Animals, Newborn; Binding, Competitive; Bridged Bicyclo C | 2007 |
The importance of genetic background on pain behaviours and pharmacological sensitivity in the rat spared serve injury model of peripheral neuropathic pain.
Topics: Amines; Analgesics; Analgesics, Opioid; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal | 2007 |
Metabolic progression markers of neurodegeneration in the transgenic G93A-SOD1 mouse model of amyotrophic lateral sclerosis.
Topics: Age Factors; Amyotrophic Lateral Sclerosis; Analysis of Variance; Animals; Aspartic Acid; Disease Mo | 2007 |
Role of spinal voltage-dependent calcium channel alpha 2 delta-1 subunit in the expression of a neuropathic pain-like state in mice.
Topics: Amines; Analgesics; Animals; Calcium Channels; Cells, Cultured; Cyclohexanecarboxylic Acids; Disease | 2007 |
Discovery of 4-aminobutyric acid derivatives possessing anticonvulsant and antinociceptive activities: a hybrid pharmacophore approach.
Topics: Analgesics; Animals; Anticonvulsants; Disease Models, Animal; gamma-Aminobutyric Acid; Hyperalgesia; | 2007 |
Therapeutic concepts in succinate semialdehyde dehydrogenase (SSADH; ALDH5a1) deficiency (gamma-hydroxybutyric aciduria). Hypotheses evolved from 25 years of patient evaluation, studies in Aldh5a1-/- mice and characterization of gamma-hydroxybutyric acid
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Anticonvulsants; Disease Models, Animal; gamma-Aminob | 2007 |
Extracellular levels of serotonin and GABA in the hippocampus after chronic mild stress in rats. A microdialysis study in an animal model of depression.
Topics: Analysis of Variance; Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Depression; D | 2007 |
Transmeningeal delivery of GABA to control neocortical seizures in rats.
Topics: Acetylcholine; Analysis of Variance; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response | 2007 |
Effects of dietary administration of plant-derived anthocyanin-rich colors to spontaneously hypertensive rats.
Topics: Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Animals; Anthocyanins; Blood Pressur | 2007 |
Chronic lamotrigine does not alter the turnover of arachidonic acid within brain phospholipids of the unanesthetized rat: implications for the treatment of bipolar disorder.
Topics: Acyl Coenzyme A; Animals; Antimanic Agents; Arachidonic Acid; Bipolar Disorder; Brain; Disease Model | 2007 |
Upregulation of GAD65 mRNA in the medulla of the rat model of metabolic syndrome.
Topics: Animals; Autonomic Pathways; Cardiovascular Physiological Phenomena; Cardiovascular System; Disease | 2007 |
Prenatal exposure to valproic acid disturbs the enkephalinergic system functioning, basal hedonic tone, and emotional responses in an animal model of autism.
Topics: Animals; Anticonvulsants; Anxiety; Autistic Disorder; Basal Ganglia; Conditioning, Classical; Diseas | 2007 |
Oscillatory potentials of the slow-sequence multifocal ERG in primates extracted using the Matching Pursuit method.
Topics: Animals; Disease Models, Animal; Electroretinography; gamma-Aminobutyric Acid; Glaucoma; Macaca; N-M | 2007 |
Time course of changes in pyridoxal 5'-phosphate (vitamin B6 active form) and its neuroprotection in experimental ischemic damage.
Topics: 4-Aminobutyrate Transaminase; Aldehyde Oxidoreductases; Animals; Astrocytes; Brain Infarction; Brain | 2007 |
Hippocampal gene expression profiling reveals the possible involvement of Homer1 and GABA(B) receptors in scopolamine-induced amnesia.
Topics: Amnesia; Animals; Carrier Proteins; Disease Models, Animal; GABA Antagonists; GABA-B Receptor Antago | 2007 |
The differential effects of 5-HT(1A) receptor stimulation on dopamine receptor-mediated abnormal involuntary movements and rotations in the primed hemiparkinsonian rat.
Topics: Adrenergic Agents; Analysis of Variance; Animals; Behavior, Animal; Biogenic Monoamines; Chromatogra | 2007 |
GABAergic mechanisms in absence epilepsy: a computational model of absence epilepsy simulating spike and wave discharges after vigabatrin in WAG/Rij rats.
Topics: Action Potentials; Animals; Animals, Genetically Modified; Anticonvulsants; Brain; Computer Simulati | 2007 |
5-Hydroxytryptamine 1A/7 and 4alpha receptors differentially prevent opioid-induced inhibition of brain stem cardiorespiratory function.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Brain Stem; Cardiovascular Physiological Phenomen | 2007 |
Increased dietary salt enhances sympathoexcitatory and sympathoinhibitory responses from the rostral ventrolateral medulla.
Topics: Analysis of Variance; Animals; Blood Pressure; Blood Pressure Determination; Disease Models, Animal; | 2007 |
Alterations of hippocampal and prefrontal GABAergic interneurons in an animal model of psychosis induced by NMDA receptor antagonism.
Topics: Animals; Antipsychotic Agents; Disease Models, Animal; Dizocilpine Maleate; gamma-Aminobutyric Acid; | 2007 |
Aberrant cerebellar granule cell-specific GABAA receptor expression in the epileptic and ataxic mouse mutant, Tottering.
Topics: Animals; Binding, Competitive; Calcium Channels, N-Type; Cerebellar Ataxia; Cerebellar Cortex; Disea | 2007 |
Basal ganglia neurotransmitter concentrations in rhesus monkeys following subchronic manganese sulfate inhalation.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Basal Ganglia; Disease Models, Animal; Dopamine; gamma-Amin | 2007 |
Loss of phase synchrony in an animal model of partial status epilepticus.
Topics: Action Potentials; Animals; Cerebral Cortex; Cortical Synchronization; Disease Models, Animal; Elect | 2007 |
The alpha7 nicotinic receptor agonist 4OH-GTS-21 protects axotomized septohippocampal cholinergic neurons in wild type but not amyloid-overexpressing transgenic mice.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Amyloid; Anabasine; Animals; Axotomy; Ce | 2007 |
Activation of central adenosine A(2A) receptors enhances superior laryngeal nerve stimulation-induced apnea in piglets via a GABAergic pathway.
Topics: Adenosine; Animals; Animals, Newborn; Apnea; Bicuculline; Blood Pressure; Cisterna Magna; Disease Mo | 2007 |
Gabapentin action and interaction on the antinociceptive effect of morphine on visceral pain in mice.
Topics: Acetic Acid; Amines; Analgesics; Analgesics, Opioid; Analysis of Variance; Animals; Cyclohexanecarbo | 2008 |
Transient allodynia pain models in mice for early assessment of analgesic activity.
Topics: Adrenergic alpha-Antagonists; Amines; Amitriptyline; Analgesics; Animals; Clonidine; Cyclohexanecarb | 2008 |
Spinal GABAergic transplants attenuate mechanical allodynia in a rat model of neuropathic pain.
Topics: Animals; Brain Tissue Transplantation; Cells, Cultured; Disease Models, Animal; Female; Fetal Tissue | 2007 |
Elevated spectroscopic glutamate/gamma-amino butyric acid in rats bred for learned helplessness.
Topics: Animals; Behavior, Animal; Brain; Depression; Disease Models, Animal; gamma-Aminobutyric Acid; Gluta | 2007 |
Astrocytes may play a role in the etiology of absence epilepsy: a comparison between immature GAERS not yet expressing seizures and adults.
Topics: Acetic Acid; Aging; Animals; Astrocytes; Brain; Cell Communication; Cell Differentiation; Disease Mo | 2007 |
Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cognition Disorde | 2007 |
Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cognition Disorde | 2007 |
Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cognition Disorde | 2007 |
Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cognition Disorde | 2007 |
Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cognition Disorde | 2007 |
Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cognition Disorde | 2007 |
Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cognition Disorde | 2007 |
Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cognition Disorde | 2007 |
Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cognition Disorde | 2007 |
Newer N-phthaloyl GABA derivatives with antiallodynic and antihyperalgesic activities in both sciatic nerve and spinal nerve ligation models of neuropathic pain.
Topics: Analgesics; Animals; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Hyperalgesia; Male; Mi | 2008 |
The properties of reticular thalamic neuron GABA(A) IPSCs of absence epilepsy rats lead to enhanced network excitability.
Topics: Action Potentials; Animals; Disease Models, Animal; Dose-Response Relationship, Radiation; Electric | 2007 |
Pregabalin, S-(+)-3-isobutylgaba, activates the descending noradrenergic system to alleviate neuropathic pain in the mouse partial sciatic nerve ligation model.
Topics: Adrenergic Agents; Afferent Pathways; Analgesics; Animals; Behavior, Animal; Brain Stem; Disease Mod | 2007 |
A role for conditioned ventral tegmental glutamate release in cocaine seeking.
Topics: Animals; Behavior, Addictive; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Conditioning, Ps | 2007 |
The involvement of the substantia nigra pars reticulata in hypoglycemic seizures.
Topics: Animals; Baclofen; Behavior, Animal; Disease Models, Animal; Fasting; GABA-A Receptor Agonists; gamm | 2007 |
Mechanism of age-dependent susceptibility and novel treatment strategy in glutaric acidemia type I.
Topics: Aging; Amino Acid Metabolism, Inborn Errors; Animals; Brain Diseases, Metabolic, Inborn; Child; Diet | 2007 |
Gabapentin suppresses spasticity in the spinal cord-injured rat.
Topics: Amines; Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Cross-Over Studies; Cycloh | 2007 |
Antinociceptive action of limonexic acid obtained from Raulinoa echinata.
Topics: Acetaminophen; Analgesics; Animals; Aspirin; Disease Models, Animal; Dose-Response Relationship, Dru | 2007 |
Evaluation of ketamine, nimodipine, gabapentin and imipramine in partial sciatic nerve transection model of neuropathic pain in rat: an experimental study.
Topics: Amines; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin; gamma-Aminobutyric | 2007 |
Progesterone attenuates neuroleptic-induced orofacial dyskinesia via the activity of its metabolite, allopregnanolone, a positive GABA(A) modulating neurosteroid.
Topics: Animals; Antipsychotic Agents; Brain Diseases; Control Groups; Disease Models, Animal; Dopamine; Dys | 2008 |
Diminished neurosteroid sensitivity of synaptic inhibition and altered location of the alpha4 subunit of GABA(A) receptors in an animal model of epilepsy.
Topics: Animals; Benzodiazepines; Disease Models, Animal; Drug Resistance; Epilepsy, Temporal Lobe; gamma-Am | 2007 |
The effect of electroacupuncture on spontaneous recurrent seizure and expression of GAD(67) mRNA in dentate gyrus in a rat model of epilepsy.
Topics: Acupuncture Points; Animals; Convulsants; Dentate Gyrus; Disease Models, Animal; Electroacupuncture; | 2008 |
Abnormal striatal GABA transmission in the mouse model for the fragile X syndrome.
Topics: Animals; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Electric Stimulation; Fragile X M | 2008 |
Early defects of GABAergic synapses in the brain stem of a MeCP2 mouse model of Rett syndrome.
Topics: Animals; Brain Stem; Disease Models, Animal; Efferent Pathways; Excitatory Postsynaptic Potentials; | 2008 |
Brainstem amino acid neurotransmitters and ventilatory response to hypoxia in piglets.
Topics: Acid-Base Equilibrium; Amino Acids; Animals; Animals, Newborn; Aspartic Acid; Blood Pressure; Carbon | 2008 |
Seizure activity and changes in hippocampal extracellular glutamate, GABA, dopamine and serotonin.
Topics: Analysis of Variance; Animals; Behavior, Animal; Chromatography, Liquid; Disease Models, Animal; Dop | 2008 |
Altered spatial distribution of PV-cortical cells and dysmorphic neurons in the somatosensory cortex of BCNU-treated rat model of cortical dysplasia.
Topics: Animals; Animals, Newborn; Antibodies; Calbindins; Carmustine; Classical Lissencephalies and Subcort | 2008 |
Metabolic changes detected by proton magnetic resonance spectroscopy in vivo and in vitro in a murin model of Parkinson's disease, the MPTP-intoxicated mouse.
Topics: Animals; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Dopamine; gamma-Aminobutyric Acid | 2008 |
Increased truncated TrkB receptor expression and decreased BDNF/TrkB signaling in the frontal cortex of reeler mouse model of schizophrenia.
Topics: Animals; Blotting, Western; Brain-Derived Neurotrophic Factor; Cell Adhesion Molecules, Neuronal; Di | 2008 |
Neuroactive Steroid Levels in a transgenic rat model of CMT1A Neuropathy.
Topics: Animals; Animals, Genetically Modified; Axons; Charcot-Marie-Tooth Disease; Chromatography, Liquid; | 2008 |
Pharmacologic investigation of the mechanism underlying cold allodynia using a new cold plate procedure in rats with chronic constriction injuries.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Calcium Channel Blockers; Chronic Disease; Cold Tempe | 2008 |
Sedative and anticonvulsant effects of zolpidem in adult and aged mice.
Topics: Age Factors; Animals; Anticonvulsants; Brain; Convulsants; Diazepam; Disease Models, Animal; Dose-Re | 2008 |
Chronic pentylenetetrazole but not donepezil treatment rescues spatial cognition in Ts65Dn mice, a model for Down syndrome.
Topics: Acetylcholine; Animals; Brain; Cholinesterase Inhibitors; Cognition Disorders; Dementia; Disease Mod | 2008 |
Metabonomic analysis identifies molecular changes associated with the pathophysiology and drug treatment of bipolar disorder.
Topics: Adult; Analysis of Variance; Animals; Antimanic Agents; Aspartic Acid; Bipolar Disorder; Case-Contro | 2009 |
[Correction of cardiotoxic effect of chronic alcoholic intoxication by GABA-ergic compounds].
Topics: Alcoholism; Animals; Disease Models, Animal; Drug Therapy, Combination; GABA Agents; gamma-Aminobuty | 2007 |
Gabapentin evoked changes in functional activity in nociceptive regions in the brain of the anaesthetized rat: an fMRI study.
Topics: Administration, Oral; Amines; Analgesics; Animals; Blood Pressure; Brain; Brain Mapping; Cyclohexane | 2008 |
Extracellular hypothalamic gamma-aminobutyric acid (GABA) and L-glutamic acid concentrations in response to bicuculline in a genetic absence epilepsy rat model.
Topics: Animals; Bicuculline; Blood Pressure; Convulsants; Disease Models, Animal; Electroencephalography; E | 2008 |
Nociceptin-receptor deficiency prevents postherpetic pain without effects on acute herpetic pain in mice.
Topics: Acute Disease; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gab | 2008 |
Experimental autoimmune prostatitis induces chronic pelvic pain.
Topics: Amines; Analgesics; Anesthetics, Local; Animals; Autoimmune Diseases; Chronic Disease; Cyclohexaneca | 2008 |
Ethanol enhances reactivated fear memories.
Topics: Alcohol-Induced Disorders, Nervous System; Animals; Brain; Brain Chemistry; Central Nervous System D | 2008 |
Increased thalamic inhibition in the absence seizure prone DBA/2J mouse.
Topics: Animals; Brain Mapping; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Epilepsy, A | 2008 |
Metabolic markers of neuronal injury correlate with SIV CNS disease severity and inoculum in the macaque model of neuroAIDS.
Topics: AIDS Dementia Complex; Analysis of Variance; Animals; Aspartic Acid; Choline; Creatine; Disease Mode | 2008 |
Impact of receptor changes on treatment of status epilepticus.
Topics: Action Potentials; Animals; Benzodiazepines; Cholinesterase Inhibitors; Disease Models, Animal; Drug | 2007 |
Chronic, but not acute, tricyclic antidepressant treatment alleviates neuropathic allodynia after sciatic nerve cuffing in mice.
Topics: Amines; Amitriptyline; Animals; Anticonvulsants; Antidepressive Agents, Tricyclic; Brain; Chronic Di | 2008 |
Loss of Perineuronal Net in ME7 Prion Disease.
Topics: Animals; Disease Models, Animal; Disease Progression; Encephalitis; Extracellular Matrix; Female; ga | 2008 |
Increased GABAergic tone in the ventromedial hypothalamus contributes to suppression of counterregulatory responses after antecedent hypoglycemia.
Topics: Animals; Disease Models, Animal; DNA Primers; gamma-Aminobutyric Acid; Gene Expression Regulation, E | 2008 |
Gabapentin neuroprotection and seizure suppression in immature mouse brain ischemia.
Topics: Amines; Animals; Animals, Newborn; Anticonvulsants; Atrophy; Behavior, Animal; Body Temperature; Bra | 2008 |
Newer GABA derivatives for the treatment of epilepsy including febrile seizures: a bioisosteric approach.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Dru | 2008 |
Expression of GABA A receptor alpha1 subunit mRNA and protein in rat neocortex following photothrombotic infarction.
Topics: Animals; Cerebral Infarction; Disease Models, Animal; Down-Regulation; Epilepsy; Functional Laterali | 2008 |
Alterations in nigral NMDA and GABAA receptor control of the striatal dopamine level after repetitive exposures to nitrogen narcosis.
Topics: Air Pressure; Animals; Atmosphere Exposure Chambers; Basal Ganglia Diseases; Corpus Striatum; Diseas | 2008 |
Olanzapine counteracts stress-induced anxiety-like behavior in rats.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Animals; Anti-Anxiety Agents; A | 2008 |
The glutamatergic projection from the prefrontal cortex to the nucleus accumbens core is required for cocaine-induced decreases in ventral pallidal GABA.
Topics: Animals; Basal Ganglia; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Uptake | 2008 |
Diabetes affects the expression of GABA and potassium chloride cotransporter in the spinal cord: a study in streptozotocin diabetic rats.
Topics: Animals; Blotting, Western; Chlorides; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disea | 2008 |
Synaptic input to dentate granule cell basal dendrites in a rat model of temporal lobe epilepsy.
Topics: Animals; Cell Shape; Convulsants; Dendrites; Dentate Gyrus; Disease Models, Animal; Epilepsy, Tempor | 2008 |
[Changes of amino acids neurotransmitters in striatum of hemi-parkinsonian rhesus monkey after high frequency stimulation of subthalamic nucleus].
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amino Acids; Animals; Chromatography, High Pressure Li | 2007 |
Spinal cord injury causes plasticity in a subpopulation of lamina I GABAergic interneurons.
Topics: Animals; Animals, Newborn; Cadmium; Calcium Channel Blockers; Disease Models, Animal; Dose-Response | 2008 |
Recurrent collateral connections of striatal medium spiny neurons are disrupted in models of Parkinson's disease.
Topics: Animals; Animals, Newborn; Corpus Striatum; Dendritic Spines; Disease Models, Animal; Excitatory Ami | 2008 |
The antinociceptive effects of anticonvulsants in a mouse visceral pain model.
Topics: Acetic Acid; Amines; Analgesics; Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Cyclohex | 2008 |
GABA and benzodiazepine receptors in basal ganglia function.
Topics: Animals; Basal Ganglia; Caudate Nucleus; Corpus Striatum; Disease Models, Animal; gamma-Aminobutyric | 1984 |
Gamma-aminobutyric acid and basal ganglia outflow pathways.
Topics: Animals; Basal Ganglia; Catalepsy; Disease Models, Animal; gamma-Aminobutyric Acid; Haloperidol; Hum | 1984 |
Kindling: an animal model of complex partial epilepsy.
Topics: Amygdala; Animals; Brain; Disease Models, Animal; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; | 1984 |
Hepatic encephalopathy and the gamma-aminobutyric-acid neurotransmitter system.
Topics: 4-Aminobutyrate Transaminase; Animals; Barbiturates; Benzodiazepines; Blood-Brain Barrier; Disease M | 1982 |
Neurotransmitter chemistry in feline GM1 gangliosidosis: a model for human ganglioside storage disease.
Topics: Animals; Brain; Cats; Cerebellum; Disease Models, Animal; Frontal Lobe; G(M1) Ganglioside; gamma-Ami | 1982 |
Enhancing GABAergic transmission reverses the aversive state in rats induced by electrical stimulation of the periaqueductal grey region.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Diazepam; Disease Models, Animal; Drug Interactions; Electric | 1982 |
The release and neosynthesis of glutamic acid are increased in experimental models of hepatic encephalopathy.
Topics: Acetates; Animals; Cerebral Cortex; Disease Models, Animal; gamma-Aminobutyric Acid; Glucose; Glutam | 1983 |
A theory of anxiety: the role of the limbic system.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Disease Models, Animal; gamma-Aminobutyric Acid; Hippocampus; | 1983 |
Evidence for neurotransmitter abnormalities related to seizure activity in the epileptic baboon.
Topics: 5-Hydroxytryptophan; Acetylcholine; Amphetamine; Animals; Brain; Disease Models, Animal; Dopamine; E | 1984 |
Role of neurotransmitters in seizure mechanisms in the kindling model of epilepsy.
Topics: Animals; Brain; Disease Models, Animal; Dopamine; Epilepsy; gamma-Aminobutyric Acid; Kindling, Neuro | 1984 |
Evidence for a role of neurotransmitters in the mechanism of topical convulsant models.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Aspartic Acid; Brain; Choline O-Acetyltransferase; Dis | 1984 |
Neurotransmitters and epilepsy: distinguishing characteristics and unifying precepts.
Topics: Animals; Brain; Disease Models, Animal; Electroshock; Epilepsy; gamma-Aminobutyric Acid; Kindling, N | 1984 |
[Pathogenesis of hepatic encephalopathy--studies in the rabbit model of acute liver failure].
Topics: Ammonia; Animals; Arousal; Brain; Disease Models, Animal; Electroencephalography; Evoked Potentials, | 1984 |
Experimental hepatic encephalopathy: changes in the binding of gamma-aminobutyric acid.
Topics: Bicuculline; Binding, Competitive; Brain; Disease Models, Animal; Galactosamine; gamma-Aminobutyric | 1982 |
Central gamma-aminobutyric acid involvement in blood pressure control.
Topics: Animals; Bicuculline; Blood Pressure; Brain; Cats; Disease Models, Animal; gamma-Aminobutyric Acid; | 1984 |
Indications for the use of gamma-aminobutyric acid (GABA)-agonists in convulsant disorders.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsies, Partial; Epilepsy; gamma-Aminobutyric | 1983 |
High anticonvulsant potency of gamma-aminobutyric acid (GABA)mimetic drugs in gerbils with genetically determined epilepsy.
Topics: Alkynes; Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Diazepam; Disease Models, An | 1983 |
An analysis of the cortical and striatal involvement in dyskinesia induced in rats by intracerebral injection of GABA-transaminase inhibitors and picrotoxin.
Topics: 4-Aminobutyrate Transaminase; Administration, Topical; Animals; Brain; Cerebral Cortex; Corpus Stria | 1980 |
Penicillin spikes in rats. Limitations of a simple model for the study of anticonvulsants.
Topics: Action Potentials; Animals; Anticonvulsants; Dimethyl Sulfoxide; Disease Models, Animal; Drug Evalua | 1984 |
A loss of GABAergic hippocampus innervation in rats with cobalt-induced epilepsy demonstrated by Wolman's fluorescence method.
Topics: Animals; Cobalt; Disease Models, Animal; Electroencephalography; Epilepsy; gamma-Aminobutyric Acid; | 1981 |
Galloping induced by pontine tegmentum damage in rats: a form of "Parkinsonian festination" not blocked by haloperidol.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Haloperidol; Locomotion; Male; Motor Activ | 1981 |
Anticonvulsant effects of PGE2 on electrical, chemical and photomyoclonic animal models of epilepsy.
Topics: Animals; Anticonvulsants; Brain; Dinoprostone; Disease Models, Animal; Electric Stimulation; gamma-A | 1981 |
Effect of baclofen and haloperidol on gamma-aminobutyric acid and dopamine systems in an animal model of tardive dyskinesia.
Topics: Animals; Baclofen; Brain Chemistry; Disease Models, Animal; Dopamine; Drug Interactions; Dyskinesia, | 1982 |
Baclofen as an anticonvulsant in experimental models of convulsions.
Topics: 3-Mercaptopropionic Acid; Acoustic Stimulation; Animals; Baclofen; Disease Models, Animal; Dose-Resp | 1981 |
Requirements for an ideal alcohol antagonist.
Topics: Alcoholic Intoxication; Animals; Caffeine; Cats; Dextroamphetamine; Disease Models, Animal; Dogs; Et | 1980 |
Allopregnanolone potentiates a GABA-withdrawal syndrome in the rat cerebral cortex.
Topics: Animals; Anti-Anxiety Agents; Cerebral Cortex; Disease Models, Animal; Drug Synergism; Electroenceph | 1995 |
Prevention of neuronal cell death by anticonvulsants in experimental epilepsy (extended abstract).
Topics: Amygdala; Animals; Anticonvulsants; Brain; Carbamazepine; Cell Survival; Disease Models, Animal; gam | 1995 |
Mice lacking tissue non-specific alkaline phosphatase die from seizures due to defective metabolism of vitamin B-6.
Topics: Alkaline Phosphatase; Animals; Brain Chemistry; Calcification, Physiologic; Disease Models, Animal; | 1995 |
Effects of the GABA-uptake inhibitor tiagabine on electroencephalogram, spike-wave discharges and behaviour of rats.
Topics: Action Potentials; Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Electroenceph | 1995 |
Hippocampal GABA transporter function in temporal-lobe epilepsy.
Topics: Amygdala; Animals; Carrier Proteins; Disease Models, Animal; Epilepsy, Temporal Lobe; GABA Plasma Me | 1995 |
Effects of amitriptyline on GABA-stimulated 36CI- uptake in relation to a behavioral model of depression.
Topics: Amitriptyline; Analysis of Variance; Animals; Chlorine; Depression; Disease Models, Animal; Dominanc | 1995 |
Profound systemic hypothermia inhibits the release of neurotransmitter amino acids in spinal cord ischemia.
Topics: Analysis of Variance; Animals; Aspartic Acid; Cardiopulmonary Bypass; Disease Models, Animal; Evoked | 1995 |
Effect of green tea rich in gamma-aminobutyric acid on blood pressure of Dahl salt-sensitive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Disease Models, Animal; Female; gamma | 1995 |
Further evidence for the interactions between angiotensin II and GABAergic transmission in pentylenetetrazol kindling seizures in mice.
Topics: Angiotensin II; Animals; Baclofen; Disease Models, Animal; Dose-Response Relationship, Drug; Drug In | 1995 |
A possible role for phospholipases in the release of neurotransmitter amino acids from ischemic rat cerebral cortex.
Topics: Amino Acids; Animals; Aspartic Acid; Brain Ischemia; Disease Models, Animal; gamma-Aminobutyric Acid | 1995 |
Enlargement of GAD-immunopositive terminals in the lateral vestibular nucleus (LVN) of weaver mutant mice.
Topics: Animals; Cerebellar Ataxia; Cerebellum; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Glu | 1995 |
Tiagabine inhibits haloperidol-induced oral dyskinesias in rats.
Topics: Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Dyskinesia, Drug-Induced; gamma-Amino | 1994 |
Effect of experimental Escherichia coli meningitis on concentrations of excitatory and inhibitory amino acids in the rabbit brain: in vivo microdialysis study.
Topics: Amino Acids; Animals; Aspartic Acid; Blood Pressure; Brain; Cerebrovascular Circulation; Disease Mod | 1993 |
NMDA-GABA interactions in an animal model of behaviour: a gating mechanism from motivation toward psychotic-like symptoms.
Topics: Alprazolam; Animals; Behavior, Animal; Desipramine; Disease Models, Animal; Dizocilpine Maleate; gam | 1994 |
gamma Aminobutyric acid mediation of the anticonvulsant effect of clonidine on pentylenetetrazol-induced seizures in mice.
Topics: Animals; Clonidine; Disease Models, Animal; gamma-Aminobutyric Acid; Mice; Pentylenetetrazole; Seizu | 1994 |
Decrease of glutamate decarboxylase activity after in vivo cortical infusion of gamma-aminobutyric acid.
Topics: Amino Acids; Animals; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Glutamate Decarboxy | 1994 |
Roles of dopamine and its receptors in generation of choreic movements.
Topics: Afferent Pathways; Animals; Brain Mapping; Cerebral Cortex; Choline O-Acetyltransferase; Chorea; Cor | 1993 |
An animal model for coexisting tardive dyskinesia and tardive parkinsonism: a glutamate hypothesis for tardive dyskinesia.
Topics: Animals; Brain Chemistry; Cebus; Disease Models, Animal; Dyskinesia, Drug-Induced; gamma-Aminobutyri | 1993 |
[The role of monoamin- and acidergic mechanisms of the hippocampus in anxiety states of different origins and their participation in the antiaversive effects of anxiolytics].
Topics: Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Chlordiazepoxide; Disease Models, Animal; | 1993 |
Noradrenaline mediates paradoxical effects on rat neocortical neurons after GABA withdrawal.
Topics: Animals; Calcium Channels; Cerebral Cortex; Culture Techniques; Disease Models, Animal; Epilepsies, | 1994 |
Some biochemical and pathophysiological aspects of long-term elevation of brain ornithine concentrations.
Topics: Animals; Brain; Carnosine; Chickens; Disease Models, Animal; Electroretinography; Eye; Female; gamma | 1993 |
Nonpeptide angiotensin II receptor antagonists. 2. Design, synthesis, and structure-activity relationships of 2-alkyl-4-(1H-pyrrol-1-yl)-1H-imidazole derivatives: profile of 2-propyl-1-[[2'-(1H-tetrazol-5-yl)-[1,1' -biphenyl]-4-yl]-methyl]-4-[2-(trifluoro
Topics: Angiotensin Receptor Antagonists; Animals; Aorta; Disease Models, Animal; GABA Antagonists; gamma-Am | 1993 |
Effects of repeated cerebral ischemia on extracellular amino acid concentrations measured with intracerebral microdialysis in the gerbil hippocampus.
Topics: Amino Acids; Animals; Brain Ischemia; Disease Models, Animal; Extracellular Space; gamma-Aminobutyri | 1993 |
Effects of compound U74500A in animal models of gastric and duodenal ulceration.
Topics: Analysis of Variance; Animals; Anti-Ulcer Agents; Cysteamine; Disease Models, Animal; Dose-Response | 1993 |
Modulation of GABA transmission by diazoxide and cromakalim in the globus pallidus: implications for the treatment of Parkinson's disease.
Topics: Animals; Antihypertensive Agents; Behavior, Animal; Benzopyrans; Cromakalim; Diazoxide; Disease Mode | 1996 |
Alpha 2-adrenoceptor agonist, dexmedetomidine, protects against kainic acid-induced convulsions and neuronal damage.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Anticonvulsants; Disease Models, A | 1995 |
Synchronous GABA-mediated potentials and epileptiform discharges in the rat limbic system in vitro.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analgesics; Animals; Disease Models, Animal; | 1996 |
Antimyoclonic effect of gabapentin in a posthypoxic animal model of myoclonus.
Topics: Acetates; Acoustic Stimulation; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; DDT; | 1996 |
Development of the glutamate, GABA, and dopamine systems in relation to NRH-induced neurotoxicity.
Topics: Age Factors; Animals; Cerebral Cortex; Disease Models, Animal; Dopamine; gamma-Aminobutyric Acid; Gl | 1995 |
Gabaergic transmission and tyrosine hydroxylase expression in the nigral dopaminergic neurons: an in vivo study using a reversible ischemia model of rats.
Topics: Animals; Brain Ischemia; Cell Count; Disease Models, Animal; Dopamine; gamma-Aminobutyric Acid; Male | 1996 |
The neurochemical pathology of thiamine deficiency: GABAA and glutamateNMDA receptor binding sites in a goat model.
Topics: Alcoholism; Amprolium; Animals; Brain Chemistry; Diazepam; Disease Models, Animal; Dizocilpine Malea | 1996 |
Developmental and seizure-related regional differences in immediate early gene expression and GABAergic abnormalities in the brain of EL mice.
Topics: Animals; Brain; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Gene Expression Regulatio | 1996 |
Analysis of the kinetics of synaptic inhibition points to a reduction in GABA release in area CA1 of the genetically epileptic mouse, El.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Anticonvulsants; Baclofen; Disease Models, Animal; El | 1996 |
Cortical versus thalamic mechanisms underlying spike and wave discharges in GAERS.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cerebral Cortex; Disease | 1996 |
Review of the role of inhibitory neurons in chronic epileptic foci induced by intracerebral tetanus toxin.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Cerebral Cortex; Disease Models, Animal; | 1996 |
Vulnerability and plasticity of the GABA system in the pilocarpine model of spontaneous recurrent seizures.
Topics: Animals; Antibodies, Monoclonal; Dentate Gyrus; Disease Models, Animal; Epilepsy, Temporal Lobe; gam | 1996 |
Utility of the lethargic (lh/lh) mouse model of absence seizures in predicting the effects of lamotrigine, vigabatrin, tiagabine, gabapentin, and topiramate against human absence seizures.
Topics: Acetates; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dru | 1997 |
The effect of novel anti-epileptic drugs in rat experimental models of acute and chronic pain.
Topics: Acetates; Acute Disease; Amines; Analgesics; Animals; Anticonvulsants; Chronic Disease; Cyclohexanec | 1997 |
Parvalbumin disappears from GABAergic CA1 neurons of the gerbil hippocampus with seizure onset while its presence persists in the perforant path.
Topics: Age of Onset; Animals; Disease Models, Animal; Entorhinal Cortex; Epilepsy; gamma-Aminobutyric Acid; | 1997 |
GABAergic neuroaxonal dystrophy and other cytopathological alterations in feline Niemann-Pick disease type C.
Topics: Age Factors; Animals; Brain Diseases; Cats; Child, Preschool; Disease Models, Animal; gamma-Aminobut | 1997 |
Comparison of the preclinical anticonvulsant profiles of tiagabine, lamotrigine, gabapentin and vigabatrin.
Topics: Acetates; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dos | 1997 |
Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase.
Topics: Animals; Animals, Newborn; Brain; Crosses, Genetic; Disease Models, Animal; Epilepsy; Female; gamma- | 1997 |
Differential responses of extracellular GABA to intrastriatal perfusions of 3-nitropropionic acid and quinolinic acid in the rat.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Enzyme Inhibitors; Excitatory Amino Acid Agonists; | 1997 |
The effect of lesionectomy and the perilesional GABAergic neuronal changes in alumina cream-induced focal motor epilepsy in cats.
Topics: Aluminum Oxide; Animals; Antibodies; Cats; Cell Count; Disease Models, Animal; Electroencephalograph | 1998 |
Magnesium deficiency-dependent audiogenic seizures (MDDASs) in adult mice: a nutritional model for discriminatory screening of anticonvulsant drugs and original assessment of neuroprotection properties.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Azepines; Brain Chemistry; Disease Models, Animal; D | 1998 |
Changes in brain organic osmolytes in experimental cerebral ischemia.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Brain Chemistry; Brain Ischemia; Creatine; Disease Mod | 1998 |
Gabapentin potentiation of the antiepileptic efficacy of vigabatrin in an in vitro model of epilepsy.
Topics: 4-Aminobutyrate Transaminase; Acetates; Amines; Animals; Anticonvulsants; Bicuculline; Cyclohexaneca | 1998 |
Validation of corneally kindled mice: a sensitive screening model for partial epilepsy in man.
Topics: Amygdala; Animals; Anticonvulsants; Carbamazepine; Cornea; Disease Models, Animal; Dizocilpine Malea | 1998 |
Modulation of spinal pain mechanisms by spinal cord stimulation and the potential role of adjuvant pharmacotherapy.
Topics: Adenosine; Animals; Baclofen; Behavior, Animal; Chemotherapy, Adjuvant; Combined Modality Therapy; D | 1997 |
Characteristics of neurons with high-frequency discharge in the central nervous system and their relationship to chronic pain. Experimental and clinical investigations.
Topics: Animals; Calcium Channel Blockers; Chronic Disease; Denervation; Disease Models, Animal; Electric St | 1997 |
Alteration of the GABAergic neuronal system of the retina and superior colliculus in streptozotocin-induced diabetic rat.
Topics: 4-Aminobutyrate Transaminase; Animals; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Diseas | 1998 |
Gabapentin suppresses ectopic nerve discharges and reverses allodynia in neuropathic rats.
Topics: Acetates; Afferent Pathways; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Disease | 1999 |
Alterations in spontaneous single unit activity of striatal subdivisions during ontogenesis in mutant dystonic hamsters.
Topics: Animals; Cricetinae; Disease Models, Animal; Dystonia; Electrophysiology; gamma-Aminobutyric Acid; M | 1999 |
Brain neurotransmitter deficits in mice transgenic for the Huntington's disease mutation.
Topics: Animals; Brain Chemistry; Disease Models, Animal; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; | 1999 |
Gabapentin decreases the severity of dystonia at low doses in a genetic animal model of paroxysmal dystonic choreoathetosis.
Topics: Acetates; Amines; Animals; Anticonvulsants; Cricetinae; Cyclohexanecarboxylic Acids; Disease Models, | 1999 |
5-HT receptor knockout mice: pharmacological tools or models of psychiatric disorders.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aggression; Animals; Behavior, Animal; Cocaine; Disease Models, Anim | 1999 |
Febrile convulsions: a 'benign' condition?
Topics: Animals; Child, Preschool; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; | 1999 |
Up-regulation of GAD65 and GAD67 in remaining hippocampal GABA neurons in a model of temporal lobe epilepsy.
Topics: Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Gene Expression R | 1999 |
Hypothermia ameliorates ischemic brain damage and suppresses the release of extracellular amino acids in both normo- and hyperglycemic subjects.
Topics: Animals; Brain; Brain Ischemia; Corpus Striatum; Disease Models, Animal; Excitatory Amino Acids; Ext | 1999 |
The IGF-I amino-terminal tripeptide glycine-proline-glutamate (GPE) is neuroprotective to striatum in the quinolinic acid lesion animal model of Huntington's disease.
Topics: Animals; Calbindin 2; Calbindins; Cell Count; Choline O-Acetyltransferase; Cholinergic Fibers; Corpu | 1999 |
Evaluation of interaction between gabapentin and ibuprofen on the formalin test in rats.
Topics: Acetates; Amines; Analgesics; Analgesics, Non-Narcotic; Animals; Blood Pressure; Cyclohexanecarboxyl | 1999 |
Striatal outflow of adenosine, excitatory amino acids, gamma-aminobutyric acid, and taurine in awake freely moving rats after middle cerebral artery occlusion: correlations with neurological deficit and histopathological damage.
Topics: Adenosine; Animals; Arterial Occlusive Diseases; Brain Ischemia; Cerebral Cortex; Chromatography, Hi | 1999 |
Anticonvulsant activity of PNU-151774E in the amygdala kindled model of complex partial seizures.
Topics: Acetates; Alanine; Amines; Amygdala; Animals; Anticonvulsants; Behavior, Animal; Benzylamines; Carba | 1999 |
Carbonic anhydrase inhibitors. Part 79. Synthesis of topically acting sulfonamides incorporating GABA moieties in their molecule, with long-lasting intraocular pressure-lowering properties.
Topics: Administration, Topical; Animals; Carbonic Anhydrase Inhibitors; Cell Membrane; Cornea; Cytosol; Dis | 1999 |
Cerebral oligaemia episode triggers free radical formation and late cognitive deficiencies.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aspartic Acid; Carotid Stenosis; Cognition Disorders; Corpu | 2000 |
Brain inflammatory reaction in an animal model of neuronal degeneration and its modulation by an anti-inflammatory drug: implication in Alzheimer's disease.
Topics: Acetylcholine; Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Choline O-Acetyl | 2000 |
Characterization of neuronal migration disorders in neocortical structures: loss or preservation of inhibitory interneurons?
Topics: Adult; Animals; Animals, Newborn; Calbindins; Cell Count; Disease Models, Animal; Epilepsy; Freezing | 2000 |
Testing the disinhibition hypothesis of epileptogenesis in vivo and during spontaneous seizures.
Topics: Animals; Cell Count; Dentate Gyrus; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Gerbi | 2000 |
Morphine and gabapentin decrease mechanical hyperalgesia and escape/avoidance behavior in a rat model of neuropathic pain.
Topics: Acetates; Amines; Analgesics; Animals; Avoidance Learning; Cyclohexanecarboxylic Acids; Disease Mode | 2000 |
Viral infection of developing GABAergic neurons in a model of hippocampal disinhibition.
Topics: Animals; Central Nervous System Viral Diseases; Dentate Gyrus; Disease Models, Animal; Epilepsy, Tem | 2000 |
Further evidence for the role of the alpha(2)delta subunit of voltage dependent calcium channels in models of neuropathic pain.
Topics: Acetates; Amines; Analgesics; Animals; Calcium Channels; Cyclohexanecarboxylic Acids; Disease Models | 2000 |
Deficit of striatal parvalbumin-reactive GABAergic interneurons and decreased basal ganglia output in a genetic rodent model of idiopathic paroxysmal dystonia.
Topics: Action Potentials; Animals; Basal Ganglia; Cell Count; Corpus Striatum; Cricetinae; Disease Models, | 2000 |
Pharmacological and immunohistochemical characterization of a mouse model of acute herpetic pain.
Topics: Acetates; Amines; Amitriptyline; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; | 2000 |
Effect of oxidative stress on the uptake of GABA and glutamate in synaptosomes isolated from diabetic rat brain.
Topics: Animals; Ascorbic Acid; Blood Glucose; Body Weight; Brain; Diabetes Mellitus, Type 2; Disease Models | 2000 |
Deficits in striatal dopamine D(2) receptors and energy metabolism detected by in vivo microPET imaging in a rat model of Huntington's disease.
Topics: Animals; Autoradiography; Benzazepines; Cocaine; Corpus Striatum; Disease Models, Animal; Dopamine A | 2000 |
Valproate prevents epileptiform activity after trauma in an in vitro model in neocortical slices.
Topics: Animals; Anticonvulsants; Brain Injuries; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; | 2000 |
Neurochemical changes and laser Doppler flowmetry in the endothelin-1 rat model for focal cerebral ischemia.
Topics: Animals; Cerebral Cortex; Cerebrovascular Circulation; Corpus Striatum; Disease Models, Animal; Dopa | 2000 |
Studies on the effects of lactate transport inhibition, pyruvate, glucose and glutamine on amino acid, lactate and glucose release from the ischemic rat cerebral cortex.
Topics: Amino Acids; Animals; Biological Transport; Brain Ischemia; Cerebral Cortex; Coumaric Acids; Disease | 2001 |
In vitro 1H and 31P NMR spectroscopic evidence of multiple aberrant biochemical pathways in murine trisomy 16 brain development.
Topics: Alanine; Animals; Aspartic Acid; Biomarkers; Brain Chemistry; Choline; Creatine; Disease Models, Ani | 2000 |
Contribution of GABA(A) and GABA(B) receptors to thalamic neuronal activity during spontaneous absence seizures in rats.
Topics: Action Potentials; Animals; Bicuculline; Disease Models, Animal; Electroencephalography; Epilepsy, A | 2001 |
Amygdalar activation alters the hippocampal GABA system: "partial" modelling for postmortem changes in schizophrenia.
Topics: Amygdala; Animals; Dentate Gyrus; Disease Models, Animal; GABA Antagonists; gamma-Aminobutyric Acid; | 2001 |
Gamma-hydroxybutyric acid-induced absence seizures in GluR2 null mutant mice.
Topics: Animals; Blotting, Western; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; gamma | 2001 |
[The effect of gabapentin and gabapentin-lactam on retinal ganglion cell survival. Situation after acute retinal ischemia in animal models].
Topics: Acetates; Amines; Animals; Anticonvulsants; Aza Compounds; Cell Survival; Convulsants; Cyclohexaneca | 2001 |
The role of neurochemical mechanisms of ventromedial hypothalamus in various models of anxiety in rats.
Topics: Adrenergic Agents; Animals; Anxiety; Apomorphine; Avoidance Learning; Disease Models, Animal; Dopami | 2001 |
Differential role of dopamine D1 and D2 receptors in isoniazid-induced vacuous chewing movements.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Anticonvulsants; Antipsychotic | 2000 |
Muscarinic depression of synaptic transmission in the epileptogenic GABA withdrawal syndrome focus.
Topics: Action Potentials; Animals; Atropine Derivatives; Disease Models, Animal; Excitatory Postsynaptic Po | 2001 |
Experimental uremia affects hypothalamic amino acid neurotransmitter milieu.
Topics: Amino Acids; Analysis of Variance; Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Gonadot | 2001 |
Whole-cell but not acellular pertussis vaccines induce convulsive activity in mice: evidence of a role for toxin-induced interleukin-1beta in a new murine model for analysis of neuronal side effects of vaccination.
Topics: Animals; Bordetella pertussis; Brain; Disease Models, Animal; Female; Fever; gamma-Aminobutyric Acid | 2001 |
The putative OP(4) antagonist, [Nphe(1)]nociceptin(1-13)NH(2), prevents the effects of nociceptin in neuropathic rats.
Topics: Acetates; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Res | 2001 |
Effect of gabapentin and lamotrigine on mechanical allodynia-like behaviour in a rat model of trigeminal neuropathic pain.
Topics: Acetates; Amines; Analgesics; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Disease Models | 2001 |
Anticonvulsant efficacy of gabapentin on kindling in the immature brain.
Topics: Acetates; Age Factors; Amines; Amygdala; Animals; Anticonvulsants; Behavior, Animal; Brain; Child; C | 2001 |
Changes in endocannabinoid transmission in the basal ganglia in a rat model of Huntington's disease.
Topics: Animals; Basal Ganglia; Cannabinoid Receptor Modulators; Cannabinoids; Convulsants; Disease Models, | 2001 |
Animal models of tardive dyskinesia--a review.
Topics: Animals; Antipsychotic Agents; Disease Models, Animal; Dyskinesia, Drug-Induced; Free Radicals; gamm | 2001 |
Assessing tinnitus and prospective tinnitus therapeutics using a psychophysical animal model.
Topics: Acetates; Amines; Animals; Cyclohexanecarboxylic Acids; Deafness; Diagnosis, Differential; Disease M | 2001 |
Effects of bilateral olfactory bulbectomy on N-methyl-D-aspartate receptor function: autoradiographic and behavioral studies in the rat.
Topics: Animals; Binding Sites; Brain; Denervation; Depression; Disease Models, Animal; Dizocilpine Maleate; | 2001 |
Single systemic dose of vigabatrin induces early proconvulsant and later anticonvulsant effect in rats.
Topics: Action Potentials; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Dru | 2001 |
Synthesis of novel GABA uptake inhibitors. Part 6: preparation and evaluation of N-Omega asymmetrically substituted nipecotic acid derivatives.
Topics: Animals; Disease Models, Animal; Ethers; GABA Antagonists; gamma-Aminobutyric Acid; Inhibitory Conce | 2001 |
Profiles of glutamate and GABA efflux in core versus peripheral zones of focal cerebral ischemia in mice.
Topics: Animals; Blood Flow Velocity; Brain; Brain Ischemia; Cerebrovascular Circulation; Disease Models, An | 2001 |
Antinociceptive effect of the novel compound OT-7100 in a diabetic neuropathy model.
Topics: Acetates; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Diabetic Neuropathies; Disease M | 2001 |
Involvement of metabotropic glutamate receptors in excitatory amino acid and GABA release following spinal cord injury in rat.
Topics: Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Disease Models, Animal; Excitatory Ami | 2001 |
Metabolic approach of absence seizures in a genetic model of absence epilepsy, the GAERS: study of the leucine-glutamate cycle.
Topics: Acetates; Amines; Amino Acids, Branched-Chain; Animals; Brain; Carbon Monoxide; Cells, Cultured; Cer | 2001 |
Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Genes, ras; Hippocampus; In Vitro Techniqu | 2002 |
Alleviation of motor hyperactivity and neurochemical deficits by endocannabinoid uptake inhibition in a rat model of Huntington's disease.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Convulsants; Disease Mode | 2002 |
Neuroprotective effect of interleukin-6 and IL6/IL6R chimera in the quinolinic acid rat model of Huntington's syndrome.
Topics: Acetylcholine; Animals; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Genetic Vectors; Hu | 2001 |
Spontaneous recurrent seizures and neuropathology in the chronic phase of the pilocarpine and picrotoxin model epilepsy.
Topics: Acetylcholine; Action Potentials; Aggression; Animals; Behavior, Animal; Brain; Chronic Disease; Dis | 2002 |
A unique mouse model for succinic semialdehyde dehydrogenase deficiency with implications for gamma hydroxybutyrate intoxication.
Topics: Aldehyde Oxidoreductases; Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Mice; Sodium Oxy | 2002 |
Cooling abolishes neuronal network synchronization in rat hippocampal slices.
Topics: Animals; Cryotherapy; Disease Models, Animal; Electric Stimulation; Epilepsy; Evoked Potentials; gam | 2002 |
Focal neurometabolic alterations in mice deficient for succinate semialdehyde dehydrogenase.
Topics: Aldehyde Oxidoreductases; Animals; beta-Alanine; Blotting, Western; Brain; Carboxylic Acids; Disease | 2002 |
Genetically engineered GABA-producing cells demonstrate anticonvulsant effects and long-term transgene expression when transplanted into the central piriform cortex of rats.
Topics: Amygdala; Animals; Behavior, Animal; beta-Galactosidase; Cells, Cultured; Cerebral Cortex; Disease M | 2002 |
Lesion of striatal neurones with kainic acid provides a model for Huntington's chorea.
Topics: Animals; Choline O-Acetyltransferase; Corpus Striatum; Disease Models, Animal; Dopamine; gamma-Amino | 1976 |
An animal model for Huntington's disease.
Topics: Animals; Choline O-Acetyltransferase; Corpus Striatum; Disease Models, Animal; gamma-Aminobutyric Ac | 1979 |
Effect of amino-oxyacetic acid (AOAA) on focal penicillin seizures.
Topics: Acetates; Alanine; Aminooxyacetic Acid; Animals; Aspartic Acid; Cerebral Cortex; Disease Models, Ani | 1978 |
Penicillin decreases chloride conductance in crustacean muscle: a model for the epileptic neuron.
Topics: Animals; Brachyura; Cell Membrane; Chlorides; Disease Models, Animal; Dose-Response Relationship, Dr | 1976 |
Decreased spinal cord cGMP in murine (wobbler) spontaneous lower motor neuron degeneration.
Topics: Animals; Brain Chemistry; Cyclic AMP; Cyclic GMP; Disease Models, Animal; gamma-Aminobutyric Acid; M | 1978 |
Clinical, neuropathologic and pharmacologic aspects of Huntington's disease: correlates with a new animal model.
Topics: Animals; Brain; Corpus Striatum; Disease Models, Animal; gamma-Aminobutyric Acid; Humans; Huntington | 1977 |
Gabaminergic and serotonergic modulation of the antidyskinetic effects of tiapride and oxiperomide in the model using 2-(N,N-dipropyl)animo-5,6-dihydroxytetralin.
Topics: 2-Naphthylamine; Aminobutyrates; Animals; Behavior, Animal; Benzamides; Benzimidazoles; Disease Mode | 1978 |
The concepts of thresholds of ischaemia in relation to brain structure and function.
Topics: Animals; Cell Membrane; Cerebral Cortex; Cerebrovascular Disorders; Disease Models, Animal; Evoked P | 1977 |
[Pathogenesis of stereotyped behavior].
Topics: Animals; Behavior; Caudate Nucleus; Diazepam; Disease Models, Animal; gamma-Aminobutyric Acid; Halop | 1979 |
[Biochemistry of epilepsy: the experimental audiogenic model].
Topics: Animals; Choline O-Acetyltransferase; Disease Models, Animal; Ear, Middle; gamma-Aminobutyric Acid; | 1977 |
Levels of gamma-aminobutyric acid in the dorsal grey lumbar spinal cord during the development of experimental spinal spasticity.
Topics: Aminobutyrates; Animals; Cordotomy; Disease Models, Animal; Dogs; gamma-Aminobutyric Acid; Muscle Sp | 1976 |
Neurophysiology of photically induced epilepsy in Papio papio.
Topics: Aluminum; Animals; Cerebral Cortex; Cobalt; Corpus Callosum; Disease Models, Animal; Epilepsy; Evoke | 1975 |
Photically induced epilepsy in Papio papio as a model for drug studies.
Topics: Acetylcholine; Animals; Carbamazepine; Clonazepam; Diazepam; Disease Models, Animal; Dopamine; Dose- | 1975 |
Gaba blockade, dopamine and schizophrenia: experimental activation of the mesolimbic system.
Topics: Aminobutyrates; Animals; Cats; Disease Models, Animal; Dopamine; gamma-Aminobutyric Acid; Humans; Li | 1975 |
Contents of several amino acids in the cerebellum, brain stem and cerebrum of the 'staggerer', 'weaver' and 'nervous' neurologically mutant mice.
Topics: Alanine; Amino Acids; Animals; Aspartic Acid; Brain; Brain Diseases; Brain Stem; Cerebellum; Disease | 1976 |
Cerebral amino acids and energy metabolites in the growth retarded rat fetus under normoxia and hypoxia.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Amino Acids; Animals; Brain Chemistry; Disease Mode | 1992 |
The inhibitory control of the substantia nigra over generalized non-convulsive seizures in the rat.
Topics: Animals; Brain Mapping; Disease Models, Animal; Dopamine; Epilepsy, Absence; gamma-Aminobutyric Acid | 1992 |
Neurochemical changes associated with the action of acute administration of diazepam in reversing the behavioral paradigm conditioned emotional response (CER).
Topics: Amino Acids; Animals; Anxiety; Aspartic Acid; Behavior, Animal; Biogenic Monoamines; Brain; Conditio | 1992 |
[Effect of metabolic stress on the release of glutamic acid and GABA in the brain tissue of Mongolian hamsters].
Topics: Animals; Cricetinae; Disease Models, Animal; Extracellular Space; Female; gamma-Aminobutyric Acid; G | 1992 |
Kindling increases brain levels of NAAG and seizures reduce activity of a NAAG-hydrolyzing enzyme, NAALADase.
Topics: Amygdala; Animals; Aspartic Acid; Brain; Brain Mapping; Dipeptidases; Dipeptides; Disease Models, An | 1992 |
Differing neurochemical and morphological sequelae of global ischemia: comparison of single- and multiple-insult paradigms.
Topics: Analysis of Variance; Animals; Brain Chemistry; Brain Ischemia; Chromatography, High Pressure Liquid | 1992 |
Co-administration of progabide inhibits haloperidol-induced oral dyskinesias in rats.
Topics: Administration, Oral; Animals; Disease Models, Animal; Drug Interactions; Dyskinesia, Drug-Induced; | 1992 |
Development of tolerance to the anticonvulsant effect of vigabatrin in amygdala-kindled rats.
Topics: Amino Acids; Aminocaproates; Amygdala; Animals; Anticonvulsants; Disease Models, Animal; Drug Admini | 1992 |
Evidence for a critical role of GABAergic transmission within the thalamus in the genesis and control of absence seizures in the rat.
Topics: Aminocaproates; Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Epilepsy, | 1991 |
Animal models of amphetamine psychosis: neurotransmitter release from rat brain slices.
Topics: Amino Acids; Amphetamine; Animals; Aspartic Acid; Behavior, Animal; Brain; Cerebral Cortex; Corpus S | 1991 |
Permanently altered hippocampal structure, excitability, and inhibition after experimental status epilepticus in the rat: the "dormant basket cell" hypothesis and its possible relevance to temporal lobe epilepsy.
Topics: Animals; Calbindins; Disease Models, Animal; Electric Stimulation; Epilepsy, Temporal Lobe; gamma-Am | 1991 |
Paradoxical role of GABA in a chronic model of petit mal (absence)-like epilepsy in the rat.
Topics: Animals; Anticonvulsants; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; | 1990 |
Chronic quinolinic acid lesions in rats closely resemble Huntington's disease.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Atrophy; Biogenic Amines; Cerebra | 1991 |
Effects of pharmacological manipulation of GABAergic neurotransmission in a new mutant hamster model of paroxysmal dystonia.
Topics: Animals; Baclofen; Carbamazepine; Cricetinae; Diazepam; Disease Models, Animal; Dystonia; gamma-Amin | 1991 |
[Experimental study of the effects of fenibut and seduxen on fetal development in the last third of pregnancy].
Topics: Abortion, Threatened; Animals; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; E | 1991 |
High-performance liquid chromatographic determination of selected amino acids in rat brain by precolumn derivatization with phenylisothiocyanate.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; D | 1990 |
Chronic hypoxia in neuronal cell culture: metabolic consequences.
Topics: Alanine; Animals; Bicarbonates; Binding, Competitive; Brain Chemistry; Cell Hypoxia; Cells, Cultured | 1990 |
The alcohol tolerant and alcohol nontolerant rat lines selected for differential sensitivity to ethanol: a tool to study mechanisms of the actions of ethanol.
Topics: Alcoholism; Animals; Behavior, Animal; Catecholamines; Disease Models, Animal; Drug Tolerance; Ethan | 1990 |
GABA-gated chloride ion influx in brains of epileptic El mice.
Topics: Animals; Brain; Chlorides; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Ion Channel Ga | 1990 |
Increased brain uptake of gamma-aminobutyric acid in a rabbit model of hepatic encephalopathy.
Topics: Animals; Brain; Butanols; Carbon Radioisotopes; Disease Models, Animal; Galactosamine; gamma-Aminobu | 1990 |
Anatomically distinct output channels of the caudate nucleus and orofacial dyskinesia: critical role of the subcommissural part of the globus pallidus in oral dyskinesia.
Topics: Animals; Cats; Caudate Nucleus; Disease Models, Animal; Dyskinesia, Drug-Induced; Facial Muscles; ga | 1989 |
Increased GABA shunt activity in VMN of three hyperphagic rat models.
Topics: Animals; Diet, Reducing; Disease Models, Animal; Feeding Behavior; gamma-Aminobutyric Acid; Glucose; | 1989 |
[Oral dyskinesia in rats after a single administration of haloperidol combined with GABA-linoleamide. A model of dyskinesia in man].
Topics: Animals; Catalepsy; Disease Models, Animal; Drug Synergism; Dyskinesia, Drug-Induced; gamma-Aminobut | 1989 |
Putative biological mechanisms of the effect of iron deficiency on brain biochemistry and behavior.
Topics: Animals; Behavior, Animal; Blood-Brain Barrier; Brain; Disease Models, Animal; Dopamine; gamma-Amino | 1989 |
Experimental tardive dyskinesia.
Topics: Animals; Antipsychotic Agents; Brain; Cebus; Corpus Striatum; Disease Models, Animal; Drug Evaluatio | 1985 |
Influence of pharmacological manipulation of inhibitory and excitatory neurotransmitter systems on seizure behavior in the Mongolian gerbil.
Topics: Adrenergic alpha-Agonists; Air; Amino Acids; Animals; Anticonvulsants; Atropine; Carbidopa; Disease | 1985 |
"Epileptic" brain damage is replicated qualitatively in the rat hippocampus by central injection of glutamate or aspartate but not by GABA or acetylcholine.
Topics: Acetylcholine; Animals; Aspartic Acid; Brain; Disease Models, Animal; Epilepsy; gamma-Aminobutyric A | 1985 |
Bidirectional modulation of GABA function by beta-carbolines.
Topics: Acoustic Stimulation; Anesthesia, General; Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning | 1986 |
Effects of dynorphin1-13 on opiate binding and dopamine and GABA uptake in stroked cat brain.
Topics: Animals; Brain; Brain Ischemia; Cats; Cyclazocine; Disease Models, Animal; Dopamine; Dynorphins; Eth | 1986 |
Decreased hippocampal inhibition and a selective loss of interneurons in experimental epilepsy.
Topics: Animals; Cholecystokinin; Disease Models, Animal; Electric Stimulation; Epilepsy; gamma-Aminobutyric | 1987 |
The effects of etomidate in the cat middle cerebral artery occlusion model of brain ischaemia. An experimental study.
Topics: Animals; Brain; Brain Ischemia; Cats; Cerebral Arteries; Cerebrovascular Circulation; Disease Models | 1986 |
Role for gamma-aminobutyric acid in selective vulnerability in gerbils.
Topics: Animals; Brain Ischemia; Cell Survival; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Ger | 1989 |
Intracellular electrophysiology of CA1 pyramidal neurones in slices of the kainic acid lesioned hippocampus of the rat.
Topics: Adaptation, Physiological; Animals; Disease Models, Animal; Epilepsy, Temporal Lobe; Evoked Potentia | 1986 |
Saccadic eye movement deficits in the MPTP monkey model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Disease Models, Animal; Eye Movements; gamma- | 1986 |
Fengabine, a novel antidepressant GABAergic agent. I. Activity in models for antidepressant drugs and psychopharmacological profile.
Topics: Animals; Antidepressive Agents; Avoidance Learning; Behavior, Animal; Bicuculline; Chlorophenols; Cl | 1987 |
Anticonvulsant drug activity in a rat model of absence epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy, Absence; gamma-Aminobutyric Acid; Rats | 1987 |
The GABA-withdrawal syndrome: a new model of focal epileptogenesis.
Topics: Animals; Cerebral Cortex; Disease Models, Animal; Epilepsies, Partial; gamma-Aminobutyric Acid; Iont | 1988 |
Experimental study on central effects of carboxyethyl-gamma-aminobutyric acid (CEGABA).
Topics: 5-Hydroxytryptophan; Animals; Behavior, Animal; Brain; Disease Models, Animal; Electroencephalograph | 1988 |
Effect of pre- and postnatal alcohol consumption on GABA levels of various brain regions in the rat offspring.
Topics: Animals; Body Weight; Brain; Brain Chemistry; Disease Models, Animal; Ethanol; Female; Fetal Alcohol | 1988 |
On the role of endogenous GABA in the forced swimming test in rats.
Topics: Aminooxyacetic Acid; Animals; Brain; Depression; Disease Models, Animal; gamma-Aminobutyric Acid; Ma | 1988 |
Animal model for evaluating the convulsive liability of beta-lactam antibiotics.
Topics: Animals; Anti-Bacterial Agents; beta-Lactams; Binding, Competitive; Cefazolin; Cilastatin; Cilastati | 1988 |
Inability to produce a model of dialysis encephalopathy in the rat by aluminum administration.
Topics: Aluminum Hydroxide; Animals; Brain Chemistry; Brain Diseases; Choline O-Acetyltransferase; Disease M | 1987 |
Noradrenergic rather than GABAergic processes as the common mediation of the antidepressant profile of GABA agonists and imipramine-like drugs in animals.
Topics: Animals; Antidepressive Agents; Brain; Depression; Disease Models, Animal; gamma-Aminobutyric Acid; | 1987 |
A regional increase in the number of hippocampal GABAergic neurons and terminals in the seizure-sensitive gerbil.
Topics: Animals; Cell Count; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Gerbillinae; Glutama | 1985 |
Animal models of myoclonus using 1,2-dihydroxybenzene (catechol) and chloralose.
Topics: Acetylcholine; Animals; Brain; Catecholamines; Catechols; Chemical Phenomena; Chemistry; Chloralose; | 1986 |
Anticonvulsant action of GABA agonists and prodrugs on minor and major seizures in epileptic gerbils. Comparison with mouse models of seizure states.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Female; gamma-Aminobutyric Acid; Ger | 1985 |
Increased numbers of GABAergic neurons occur in the inferior colliculus of an audiogenic model of genetic epilepsy.
Topics: Acoustic Stimulation; Animals; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Immunoassa | 1985 |