gamma-aminobutyric acid has been researched along with Disease Exacerbation in 69 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Using US health care utilization data, a large population-based cohort study was conducted to describe clinical characteristics and medication use patterns in patients diagnosed with fibromyalgia who newly started amitriptyline, duloxetine, gabapentin, or pregabalin." | 7.79 | Clinical characteristics and medication uses among fibromyalgia patients newly prescribed amitriptyline, duloxetine, gabapentin, or pregabalin. ( Kim, SC; Landon, JE; Solomon, DH, 2013) |
| "Gabapentin is a modulator of the glutamatergic system and has been shown to prolong survival in the transgenic model of familial ALS." | 6.69 | The natural history and the effects of gabapentin in amyotrophic lateral sclerosis. ( Balzarini, C; Brigatti, M; Comazzi, F; Mazzini, L; Mora, G; Pastore, E; Pirali, I, 1998) |
| "Fibromyalgia is a common chronic pain disorder with unclear etiology." | 5.39 | Clinical characteristics and medication uses among fibromyalgia patients newly prescribed amitriptyline, duloxetine, gabapentin, or pregabalin. ( Kim, SC; Landon, JE; Solomon, DH, 2013) |
| "Gamma-aminobutyric acid (GABA) was administered orally to rats for 60 d after excision of five-sixths of their kidney volume." | 5.34 | Gamma-aminobutyric acid specifically inhibits progression of tubular fibrosis and atrophy in nephrectomized rats. ( Kim, M; Sasaki, S; Tohda, C; Yokozawa, T, 2007) |
| "Major depressive disorder is a stress-related disease associated with brain metabolic dysregulation in the glutamine-glutamate/γ-aminobutyric acid (Gln-Glu/GABA) cycle." | 3.96 | Dietary supplementation with Lactobacillus rhamnosus JB-1 restores brain neurochemical balance and mitigates the progression of mood disorder in a rat model of chronic unpredictable mild stress. ( Andres-Mach, M; Chudzik, A; Kochalska, K; Kozioł, P; Oakden, W; Orzylowska, A; Pankowska, A; Pietura, R; Rola, R; Stanisz, GJ; Słowik, T; Łazorczyk, A, 2020) |
| "Using US health care utilization data, a large population-based cohort study was conducted to describe clinical characteristics and medication use patterns in patients diagnosed with fibromyalgia who newly started amitriptyline, duloxetine, gabapentin, or pregabalin." | 3.79 | Clinical characteristics and medication uses among fibromyalgia patients newly prescribed amitriptyline, duloxetine, gabapentin, or pregabalin. ( Kim, SC; Landon, JE; Solomon, DH, 2013) |
| "To examine the in vivo effects of PD-0200347, an alpha(2)delta ligand of voltage-activated Ca(2+) channels and a compound chemically related to pregabalin and gabapentin, on the development of cartilage structural changes in an experimental dog model of osteoarthritis (OA)." | 3.73 | Oral treatment with PD-0200347, an alpha2delta ligand, reduces the development of experimental osteoarthritis by inhibiting metalloproteinases and inducible nitric oxide synthase gene expression and synthesis in cartilage chondrocytes. ( Boileau, C; Boily, M; Brunet, J; El-Kattan, A; Flory, C; Martel-Pelletier, J; Pelletier, JP; Schrier, D; Tardif, G, 2005) |
| "ECLIPSE (Evaluation of Chronic obstructive pulmonary disease to Longitudinally Identify Predictive Surrogate Endpoints) aims to identify biomarkers that correlate with clinically relevant COPD subtypes, and to assess how these may predict disease progression." | 2.77 | Targeted metabolomics identifies perturbations in amino acid metabolism that sub-classify patients with COPD. ( Cheng, KK; Connor, SC; Dong, J; Griffin, JL; Janowitz, T; Jodrell, D; Lomas, DA; MacNee, W; Riley, JH; Tal-Singer, R; Ubhi, BK, 2012) |
| "Gabapentin is a modulator of the glutamatergic system and has been shown to prolong survival in the transgenic model of familial ALS." | 2.69 | The natural history and the effects of gabapentin in amyotrophic lateral sclerosis. ( Balzarini, C; Brigatti, M; Comazzi, F; Mazzini, L; Mora, G; Pastore, E; Pirali, I, 1998) |
| "However 20-30% of patients with lacunar stroke worsen neurologically in hours or days after onset, reaching eventually an unexpectedly severe disability status." | 2.48 | Progressive lacunar stroke: review of mechanisms, prognostic features, and putative treatments. ( Del Bene, A; Inzitari, D; Lamassa, M; Palumbo, V; Piccardi, B; Saia, V, 2012) |
| "The presence of GADAb in relatives of IDDM patients and NIDDM patients predicts the development of beta-cell destruction in combination with other anti-islet autoantibodies." | 2.40 | [GAD antibody in IDDM]. ( Shima, K; Yokota, I, 1998) |
| "Major depressive disorder is a stress-related disease associated with brain metabolic dysregulation in the glutamine-glutamate/γ-aminobutyric acid (Gln-Glu/GABA) cycle." | 1.56 | Dietary supplementation with Lactobacillus rhamnosus JB-1 restores brain neurochemical balance and mitigates the progression of mood disorder in a rat model of chronic unpredictable mild stress. ( Andres-Mach, M; Chudzik, A; Kochalska, K; Kozioł, P; Oakden, W; Orzylowska, A; Pankowska, A; Pietura, R; Rola, R; Stanisz, GJ; Słowik, T; Łazorczyk, A, 2020) |
| "The Dunning rat model of prostate cancer was used." | 1.43 | Gabapentin, an Analgesic Used Against Cancer-Associated Neuropathic Pain: Effects on Prostate Cancer Progression in an In Vivo Rat Model. ( Altun, S; Bugan, I; Djamgoz, MB; Karagoz, Z, 2016) |
| "We obtained seizures and once they had 3, 15 and 45 electric stimuli, the animals were sacrificed; the cerebellum was processed for inmunohistochemistry and Western blot analysis was performed to determine Sox-1 expression." | 1.43 | Decreased Expression of Sox-1 in Cerebellum of Rat with Generalized Seizures Induced by Kindling Model. ( Custodio, V; Eguiluz-Meléndez, A; González, E; Martínez-Lazcano, JC; Paz, C; Rosiles-Abonce, A; Rubio-Osornio, C; Rubio-Osornio, M; Trejo-Solís, C, 2016) |
| "Schizophrenia is a neurodevelopmental disorder with altered expression of GABA-related genes in the prefrontal cortex (PFC)." | 1.42 | Altered cortical expression of GABA-related genes in schizophrenia: illness progression vs developmental disturbance. ( Bazmi, HH; Hoftman, GD; Lewis, DA; Li, S; Sampson, AR; Volk, DW, 2015) |
| " It may be related with using a similar dosage of dopaminergic drugs." | 1.42 | Augmentation in restless legs syndrome patients in Korea. ( Cho, YW; Jeon, JY; Lee, HB; Moon, HJ; Song, ML, 2015) |
| "Treatment with hydralazine at hypotensive dose for 12 weeks also failed to affect the proteinuria in 5 of 6 nephrectomized CKD rats." | 1.40 | Involvement of renal sympathetic nerve overactivation in the progression of chronic kidney disease in rats. ( Ayajiki, K; Funai, A; Kobuchi, S; Matsumura, Y; Ohkita, M; Suzuki, R; Tanaka, R; Tsutsui, H; Yazawa, M, 2014) |
| "Early treatment of epilepsy is warranted to avoid possible severe consequences." | 1.39 | Epilepsy and brain injury: a case report of a dramatic neuropsychiatric vicious circle. ( Angeletti, G; Carbonetti, P; Del Casale, A; Fensore, C; Ferracuti, S; Girardi, P; Kotzalidis, GD; Lazanio, S; Muzi, A; Rapinesi, C; Savoja, V; Scatena, P; Serata, D; Tatarelli, R, 2013) |
| "Long-term untreated epilepsy may expose to accident proneness and further psychiatric deterioration." | 1.39 | Epilepsy and brain injury: a case report of a dramatic neuropsychiatric vicious circle. ( Angeletti, G; Carbonetti, P; Del Casale, A; Fensore, C; Ferracuti, S; Girardi, P; Kotzalidis, GD; Lazanio, S; Muzi, A; Rapinesi, C; Savoja, V; Scatena, P; Serata, D; Tatarelli, R, 2013) |
| "Fibromyalgia is a common chronic pain disorder with unclear etiology." | 1.39 | Clinical characteristics and medication uses among fibromyalgia patients newly prescribed amitriptyline, duloxetine, gabapentin, or pregabalin. ( Kim, SC; Landon, JE; Solomon, DH, 2013) |
| "Shorter disease progression and neuralgia and PCS etiologies are favorable factors for pregabalin treatment response." | 1.39 | Effectiveness of pregabalin as monotherapy or combination therapy for neuropathic pain in patients unresponsive to previous treatments in a Spanish primary care setting. ( Blanco Tarrio, E; Gálvez Mateos, R; López Gómez, V; Pérez Páramo, M; Zamorano Bayarri, E, 2013) |
| "Patients from a previous study of neuropathic pain (NP) in the Spanish primary care setting still had symptoms despite treatment." | 1.39 | Effectiveness of pregabalin as monotherapy or combination therapy for neuropathic pain in patients unresponsive to previous treatments in a Spanish primary care setting. ( Blanco Tarrio, E; Gálvez Mateos, R; López Gómez, V; Pérez Páramo, M; Zamorano Bayarri, E, 2013) |
| "Pancreatic cancer has a poor prognosis and is associated with high levels of psychological stress that may adversely affect clinical outcomes." | 1.38 | Regulation of pancreatic cancer by neuropsychological stress responses: a novel target for intervention. ( Al-Wadei, HA; Plummer, HK; Schuller, HM; Ullah, MF, 2012) |
| "Delirium is still one of the most common and distressing symptoms in palliative care patients." | 1.38 | Reversible delirium in an advanced cancer patient. ( Jagsch, C; Kierner, KA; Watzke, HH, 2012) |
| "We show that disease progression in the TgP347L rabbit closely tracks human cone-sparing RP, including the cone-associated preservation of bipolar cell signaling and triggering of reprogramming." | 1.37 | Retinal remodeling in the Tg P347L rabbit, a large-eye model of retinal degeneration. ( Anderson, J; Jones, BW; Kondo, M; Lin, Y; Marc, RE; Rapp, K; Shaw, MV; Terasaki, H; Watt, CB; Yang, JH, 2011) |
| "Osseous metaplasia has recently been described in several cases of nephrogenic systemic fibrosis, sometimes in association with unusual clinical features such as painful hyperkeratotic spicules, palpable bony masses, and disease regression." | 1.36 | Osseous metaplasia late in the course of nephrogenic systemic fibrosis. ( Bayliss, SJ; Berk, DR; Lu, D; Miller, A; Scarlett, D; Wippold, FJ, 2010) |
| " For this purpose we conducted a dose-response study at concentrations of AMPA between 0." | 1.35 | Pattern of injury with a graded excitotoxic insult and ensuing chronic medial septal damage in the rat brain. ( Andrés, N; Batlle, M; Mahy, N; Malpesa, Y; Prats, A; Pugliese, M; Rodríguez, MJ, 2009) |
| "Gamma-aminobutyric acid (GABA) was administered orally to rats for 60 d after excision of five-sixths of their kidney volume." | 1.34 | Gamma-aminobutyric acid specifically inhibits progression of tubular fibrosis and atrophy in nephrectomized rats. ( Kim, M; Sasaki, S; Tohda, C; Yokozawa, T, 2007) |
| "01) difference when the highest dosage of the drug was administered." | 1.33 | Oral treatment with PD-0200347, an alpha2delta ligand, reduces the development of experimental osteoarthritis by inhibiting metalloproteinases and inducible nitric oxide synthase gene expression and synthesis in cartilage chondrocytes. ( Boileau, C; Boily, M; Brunet, J; El-Kattan, A; Flory, C; Martel-Pelletier, J; Pelletier, JP; Schrier, D; Tardif, G, 2005) |
| "Two weeks after induction of hydrocephalus the taurine concentration was decreased, whereas the concentration of [1,2-13C]lactate was increased in the cerebrum and that of [1,2-13C]GABA in the brainstem." | 1.32 | Astrocyte metabolism is disturbed in the early development of experimental hydrocephalus. ( Brinker, T; Kondziella, D; Lüdemann, W; Qu, H; Sletvold, O; Sonnewald, U, 2003) |
| "We studied the scrapie infection of CD40L-deficient (CD40L(-/-)) mice to see whether ablation of the CD40L gene would be beneficial or detrimental in this model of a neurodegenerative amyloidosis." | 1.32 | Rapid disease development in scrapie-infected mice deficient for CD40 ligand. ( Baier, M; Burwinkel, M; Riemer, C; Schultz, J; Schwarz, A; van Landeghem, F, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (10.14) | 18.2507 |
| 2000's | 18 (26.09) | 29.6817 |
| 2010's | 40 (57.97) | 24.3611 |
| 2020's | 4 (5.80) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, C | 1 |
| Zhang, W | 1 |
| Xu, G | 1 |
| Zhang, D | 1 |
| Zhang, C | 1 |
| Qiao, S | 1 |
| Wang, Z | 1 |
| Wang, H | 1 |
| Blicher, JU | 1 |
| Eskildsen, SF | 1 |
| Stærmose, TG | 1 |
| Møller, AT | 1 |
| Figlewski, K | 1 |
| Near, J | 1 |
| Wei, JP | 1 |
| Wen, W | 1 |
| Dai, Y | 1 |
| Qin, LX | 1 |
| Wen, YQ | 1 |
| Duan, DD | 1 |
| Xu, SJ | 1 |
| Kochalska, K | 1 |
| Oakden, W | 1 |
| Słowik, T | 1 |
| Chudzik, A | 1 |
| Pankowska, A | 1 |
| Łazorczyk, A | 1 |
| Kozioł, P | 1 |
| Andres-Mach, M | 1 |
| Pietura, R | 1 |
| Rola, R | 1 |
| Stanisz, GJ | 1 |
| Orzylowska, A | 1 |
| Tian, J | 1 |
| Song, M | 1 |
| Kaufman, DL | 1 |
| Jodoin, M | 1 |
| Rouleau, D | 1 |
| Larson-Dupuis, C | 1 |
| Gosselin, N | 1 |
| De Beaumont, L | 1 |
| Regan, DW | 1 |
| Kashiwagi, D | 1 |
| Dougan, B | 1 |
| Sundsted, K | 1 |
| Mauck, K | 1 |
| Bittencourt, S | 1 |
| Ferrazoli, E | 1 |
| Valente, MF | 1 |
| Romariz, S | 1 |
| Janisset, NRLL | 1 |
| Macedo, CE | 1 |
| Antonio, BB | 1 |
| Barros, V | 1 |
| Mundim, M | 1 |
| Porcionatto, M | 1 |
| Aarão, MC | 1 |
| Miranda, MF | 1 |
| Rodrigues, AM | 1 |
| de Almeida, AG | 1 |
| Longo, BM | 1 |
| Mello, LE | 1 |
| Joers, JM | 1 |
| Deelchand, DK | 1 |
| Lyu, T | 1 |
| Emir, UE | 2 |
| Hutter, D | 1 |
| Gomez, CM | 1 |
| Bushara, KO | 1 |
| Eberly, LE | 1 |
| Öz, G | 2 |
| Solorzano, SR | 1 |
| Imaz-Rosshandler, I | 1 |
| Camacho-Arroyo, I | 1 |
| García-Tobilla, P | 1 |
| Morales-Montor, G | 1 |
| Salazar, P | 1 |
| Arena-Ortiz, ML | 1 |
| Rodríguez-Dorantes, M | 1 |
| Choat, HM | 1 |
| Martin, A | 1 |
| Mick, GJ | 1 |
| Heath, KE | 1 |
| Tse, HM | 1 |
| McGwin, G | 1 |
| McCormick, KL | 1 |
| Rapinesi, C | 1 |
| Del Casale, A | 1 |
| Serata, D | 1 |
| Kotzalidis, GD | 1 |
| Scatena, P | 1 |
| Muzi, A | 1 |
| Lazanio, S | 1 |
| Savoja, V | 1 |
| Carbonetti, P | 1 |
| Fensore, C | 1 |
| Ferracuti, S | 1 |
| Angeletti, G | 1 |
| Tatarelli, R | 1 |
| Girardi, P | 1 |
| Kim, SC | 1 |
| Landon, JE | 1 |
| Solomon, DH | 1 |
| Blanco Tarrio, E | 1 |
| Gálvez Mateos, R | 1 |
| Zamorano Bayarri, E | 1 |
| López Gómez, V | 1 |
| Pérez Páramo, M | 1 |
| Kobuchi, S | 1 |
| Tanaka, R | 1 |
| Funai, A | 1 |
| Suzuki, R | 1 |
| Yazawa, M | 1 |
| Tsutsui, H | 1 |
| Ohkita, M | 1 |
| Ayajiki, K | 1 |
| Matsumura, Y | 1 |
| Hoftman, GD | 1 |
| Volk, DW | 1 |
| Bazmi, HH | 1 |
| Li, S | 1 |
| Sampson, AR | 1 |
| Lewis, DA | 1 |
| Musella, A | 1 |
| Sepman, H | 1 |
| Mandolesi, G | 1 |
| Gentile, A | 1 |
| Fresegna, D | 1 |
| Haji, N | 1 |
| Conrad, A | 1 |
| Lutz, B | 1 |
| Maccarrone, M | 1 |
| Centonze, D | 1 |
| Liu, Q | 1 |
| Wang, T | 1 |
| Yu, H | 1 |
| Liu, B | 1 |
| Jia, R | 1 |
| Haanpää, M | 1 |
| Jeon, JY | 1 |
| Moon, HJ | 1 |
| Song, ML | 1 |
| Lee, HB | 1 |
| Cho, YW | 1 |
| Silva, GA | 1 |
| Pradella, F | 1 |
| Moraes, A | 1 |
| Farias, A | 1 |
| dos Santos, LM | 1 |
| de Oliveira, AL | 1 |
| Shakarjian, MP | 1 |
| Ali, MS | 1 |
| Velíšková, J | 1 |
| Stanton, PK | 1 |
| Heck, DE | 1 |
| Velíšek, L | 1 |
| Bugan, I | 1 |
| Karagoz, Z | 1 |
| Altun, S | 1 |
| Djamgoz, MB | 1 |
| Rubio-Osornio, C | 1 |
| Eguiluz-Meléndez, A | 1 |
| Trejo-Solís, C | 1 |
| Custodio, V | 1 |
| Rubio-Osornio, M | 1 |
| Rosiles-Abonce, A | 1 |
| Martínez-Lazcano, JC | 1 |
| González, E | 1 |
| Paz, C | 1 |
| Du, Z | 1 |
| Chazalon, M | 1 |
| Bestaven, E | 1 |
| Leste-Lasserre, T | 1 |
| Baufreton, J | 1 |
| Cazalets, JR | 1 |
| Cho, YH | 1 |
| Garret, M | 1 |
| Ward, RE | 1 |
| Veerula, VL | 1 |
| Ezra, N | 1 |
| Travers, JB | 1 |
| Mousdicas, N | 1 |
| Matagne, V | 1 |
| Ehinger, Y | 1 |
| Saidi, L | 1 |
| Borges-Correia, A | 1 |
| Barkats, M | 1 |
| Bartoli, M | 1 |
| Villard, L | 1 |
| Roux, JC | 1 |
| Sun, HL | 1 |
| Zhu, W | 1 |
| Zhang, YR | 1 |
| Pan, XH | 1 |
| Zhang, JR | 1 |
| Chen, XM | 1 |
| Liu, YX | 1 |
| Li, SC | 1 |
| Wang, QY | 1 |
| Deng, DP | 1 |
| Oskarsson, B | 1 |
| Pelak, V | 1 |
| Quan, D | 1 |
| Hall, D | 1 |
| Foster, C | 1 |
| Galetta, S | 1 |
| Rodríguez, MJ | 1 |
| Prats, A | 1 |
| Malpesa, Y | 1 |
| Andrés, N | 1 |
| Pugliese, M | 1 |
| Batlle, M | 1 |
| Mahy, N | 1 |
| Thümen, A | 1 |
| Moser, A | 1 |
| Wolfe, KC | 1 |
| Poma, R | 1 |
| Berk, DR | 1 |
| Miller, A | 1 |
| Scarlett, D | 1 |
| Wippold, FJ | 1 |
| Bayliss, SJ | 1 |
| Lu, D | 1 |
| Janssen, SP | 1 |
| Truin, M | 1 |
| Van Kleef, M | 1 |
| Joosten, EA | 1 |
| Jones, BW | 1 |
| Kondo, M | 1 |
| Terasaki, H | 1 |
| Watt, CB | 1 |
| Rapp, K | 1 |
| Anderson, J | 1 |
| Lin, Y | 1 |
| Shaw, MV | 1 |
| Yang, JH | 1 |
| Marc, RE | 1 |
| Musgrave, T | 1 |
| Benson, C | 1 |
| Wong, G | 1 |
| Browne, I | 1 |
| Tenorio, G | 1 |
| Rauw, G | 1 |
| Baker, GB | 1 |
| Kerr, BJ | 1 |
| Carmichael, ST | 1 |
| Schuller, HM | 1 |
| Al-Wadei, HA | 1 |
| Ullah, MF | 1 |
| Plummer, HK | 1 |
| Tuite, PJ | 1 |
| Kierner, KA | 1 |
| Jagsch, C | 1 |
| Watzke, HH | 1 |
| Del Bene, A | 1 |
| Palumbo, V | 1 |
| Lamassa, M | 1 |
| Saia, V | 1 |
| Piccardi, B | 1 |
| Inzitari, D | 1 |
| Wadman, RI | 1 |
| Bosboom, WM | 1 |
| van der Pol, WL | 1 |
| van den Berg, LH | 1 |
| Wokke, JH | 1 |
| Iannaccone, ST | 1 |
| Vrancken, AF | 1 |
| Taneera, J | 1 |
| Jin, Z | 1 |
| Jin, Y | 1 |
| Muhammed, SJ | 1 |
| Zhang, E | 1 |
| Lang, S | 1 |
| Salehi, A | 1 |
| Korsgren, O | 1 |
| Renström, E | 1 |
| Groop, L | 1 |
| Birnir, B | 1 |
| Dogan, M | 1 |
| Dogan, DG | 1 |
| Kahraman, AS | 1 |
| Ozcan, O | 1 |
| Yakinci, C | 1 |
| Alkan, A | 1 |
| Ubhi, BK | 1 |
| Cheng, KK | 1 |
| Dong, J | 1 |
| Janowitz, T | 1 |
| Jodrell, D | 1 |
| Tal-Singer, R | 1 |
| MacNee, W | 1 |
| Lomas, DA | 1 |
| Riley, JH | 1 |
| Griffin, JL | 1 |
| Connor, SC | 1 |
| Gilron, I | 1 |
| Bailey, JM | 1 |
| Vandenkerkhof, EG | 1 |
| Armon, C | 1 |
| Kondziella, D | 1 |
| Qu, H | 1 |
| Lüdemann, W | 1 |
| Brinker, T | 1 |
| Sletvold, O | 1 |
| Sonnewald, U | 1 |
| Burwinkel, M | 1 |
| Schwarz, A | 1 |
| Riemer, C | 1 |
| Schultz, J | 1 |
| van Landeghem, F | 1 |
| Baier, M | 1 |
| Wepner, U | 1 |
| Boileau, C | 1 |
| Martel-Pelletier, J | 1 |
| Brunet, J | 1 |
| Tardif, G | 1 |
| Schrier, D | 1 |
| Flory, C | 1 |
| El-Kattan, A | 1 |
| Boily, M | 1 |
| Pelletier, JP | 1 |
| de Lago, E | 1 |
| Fernández-Ruiz, J | 1 |
| Ortega-Gutiérrez, S | 1 |
| Cabranes, A | 1 |
| Pryce, G | 1 |
| Baker, D | 1 |
| López-Rodríguez, M | 1 |
| Ramos, JA | 1 |
| Horvath, J | 1 |
| Coeytaux, A | 1 |
| Jallon, P | 1 |
| Landis, T | 1 |
| Temperli, P | 1 |
| Burkhard, PR | 1 |
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| Xiao, M | 1 |
| Pinnix, CC | 1 |
| Soma, A | 1 |
| Veres, I | 1 |
| Juhasz, I | 1 |
| Brown, EJ | 1 |
| Capobianco, AJ | 1 |
| Herlyn, M | 1 |
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| Wong, VC | 1 |
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| Fung, CW | 1 |
| Kato, Z | 1 |
| Asano, T | 1 |
| Kondo, N | 1 |
| Sasaki, S | 1 |
| Tohda, C | 1 |
| Kim, M | 1 |
| Yokozawa, T | 1 |
| Niessen, HG | 1 |
| Debska-Vielhaber, G | 1 |
| Sander, K | 1 |
| Angenstein, F | 1 |
| Ludolph, AC | 1 |
| Hilfert, L | 1 |
| Willker, W | 1 |
| Leibfritz, D | 1 |
| Heinze, HJ | 1 |
| Kunz, WS | 1 |
| Vielhaber, S | 1 |
| Galluzzi, KE | 1 |
| Franklin, SL | 1 |
| Love, S | 1 |
| Greene, JR | 1 |
| Betmouni, S | 1 |
| Gurney, ME | 1 |
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| Doble, A | 1 |
| Taylor, CP | 1 |
| Andrus, PK | 1 |
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| Gerlach, M | 1 |
| Desser, H | 1 |
| Youdim, MB | 1 |
| Riederer, P | 1 |
| Yokota, I | 1 |
| Shima, K | 1 |
| Hoffmann, GF | 1 |
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| Guentchev, M | 1 |
| Groschup, MH | 1 |
| Kordek, R | 1 |
| Liberski, PP | 1 |
| Budka, H | 1 |
| Mazzini, L | 1 |
| Mora, G | 1 |
| Balzarini, C | 1 |
| Brigatti, M | 1 |
| Pirali, I | 1 |
| Comazzi, F | 1 |
| Pastore, E | 1 |
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| Stubbs, EB | 1 |
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| Dávalos, A | 2 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Biperiden for Prevention of Epilepsy in Patients With Traumatic Brain Injury[NCT04945213] | Phase 3 | 312 participants (Anticipated) | Interventional | 2023-01-10 | Recruiting | ||
| A Multicentre 3 Year Longitudinal Prospective Study to Identify Novel Endpoints and Compare These With Forced Expiratory Volume in 1 Second (FEV1) for Their Ability to Measure and Predict COPD Severity and Its Progression Over Time[NCT00292552] | 2,747 participants (Actual) | Observational | 2005-12-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
11 reviews available for gamma-aminobutyric acid and Disease Exacerbation
| Article | Year |
|---|---|
The clinical utility of repetitive transcranial magnetic stimulation in reducing the risks of transitioning from acute to chronic pain in traumatically injured patients.
Topics: Acute Pain; Animals; Chronic Pain; Disease Progression; gamma-Aminobutyric Acid; Humans; Transcrania | 2018 |
Update in perioperative medicine: practice changing evidence published in 2016.
Topics: Amines; Analgesics; Anticoagulants; Antipsychotic Agents; Arthritis, Rheumatoid; Blood Transfusion; | 2017 |
[Treatment of painful diabetic polyneuropathy].
Topics: Amines; Analgesics; Antidepressive Agents, Tricyclic; Cyclohexanecarboxylic Acids; Diabetic Foot; Di | 2014 |
Brain excitability in stroke: the yin and yang of stroke progression.
Topics: Brain; Cerebral Infarction; Disease Progression; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Lea | 2012 |
Progressive lacunar stroke: review of mechanisms, prognostic features, and putative treatments.
Topics: Anticoagulants; Blood Pressure; Brain Edema; Cerebral Infarction; Disease Progression; Encephalitis; | 2012 |
Drug treatment for spinal muscular atrophy types II and III.
Topics: Acetylcarnitine; Adolescent; Amines; Child; Child, Preschool; Creatine; Cyclohexanecarboxylic Acids; | 2012 |
How can physicians and their patients with ALS decide to use the newly-available treatments to slow disease progression?
Topics: Acetates; Amines; Amyotrophic Lateral Sclerosis; Anticonvulsants; Clinical Trials as Topic; Cyclohex | 1999 |
Managing neuropathic pain.
Topics: Amines; Analgesics, Opioid; Anticonvulsants; Calcium Channel Blockers; Combined Modality Therapy; Cy | 2007 |
New horizons in molecular mechanisms underlying Parkinson's disease and in our understanding of the neuroprotective effects of selegiline.
Topics: Binding Sites; Clinical Trials as Topic; Corpus Striatum; Disease Progression; gamma-Aminobutyric Ac | 1996 |
[GAD antibody in IDDM].
Topics: Autoantibodies; Biomarkers; Diabetes Mellitus, Type 1; Disease Progression; Female; gamma-Aminobutyr | 1998 |
Cerebrospinal fluid investigations for neurometabolic disorders.
Topics: Adolescent; Biogenic Monoamines; Biomarkers; Brain Diseases, Metabolic; Child; Child, Preschool; Cli | 1998 |
4 trials available for gamma-aminobutyric acid and Disease Exacerbation
| Article | Year |
|---|---|
Effect of gamma aminobutyric acid (GABA) or GABA with glutamic acid decarboxylase (GAD) on the progression of type 1 diabetes mellitus in children: Trial design and methodology.
Topics: Adolescent; Child; Child, Preschool; Diabetes Mellitus, Type 1; Disease Progression; Double-Blind Me | 2019 |
Targeted metabolomics identifies perturbations in amino acid metabolism that sub-classify patients with COPD.
Topics: Aged; Amino Acids; Biomarkers; Body Mass Index; Cachexia; Disease Progression; Female; gamma-Aminobu | 2012 |
The natural history and the effects of gabapentin in amyotrophic lateral sclerosis.
Topics: Acetates; Administration, Oral; Adult; Aged; Amines; Amyotrophic Lateral Sclerosis; Cyclohexanecarbo | 1998 |
Neurological deterioration in acute lacunar infarctions: the role of excitatory and inhibitory neurotransmitters.
Topics: Acute Disease; Aged; Brain Infarction; Disease Progression; Female; gamma-Aminobutyric Acid; Glutami | 2001 |
54 other studies available for gamma-aminobutyric acid and Disease Exacerbation
| Article | Year |
|---|---|
Deep multilayer brain omics identifies the potential involvement of menopause molecular networks in Gliomas' disease progression.
Topics: Adult; Brain; Chloride Channels; Disease Progression; Female; gamma-Aminobutyric Acid; Glioma; Gonad | 2022 |
Short echo-time Magnetic Resonance Spectroscopy in ALS, simultaneous quantification of glutamate and GABA at 3 T.
Topics: Aged; Amyotrophic Lateral Sclerosis; Aspartic Acid; Atrophy; Choline; Creatine; Disease Progression; | 2019 |
Drinking water temperature affects cognitive function and progression of Alzheimer's disease in a mouse model.
Topics: Alzheimer Disease; Animals; Brain; Cognition; Cold Temperature; Disease Progression; Drinking Water; | 2021 |
Dietary supplementation with Lactobacillus rhamnosus JB-1 restores brain neurochemical balance and mitigates the progression of mood disorder in a rat model of chronic unpredictable mild stress.
Topics: Animals; Aspartic Acid; Behavior, Animal; Brain; Choline; Depressive Disorder; Dietary Supplements; | 2020 |
Homotaurine limits the spreading of T cell autoreactivity within the CNS and ameliorates disease in a model of multiple sclerosis.
Topics: Animals; Antigen Presentation; Antigen-Presenting Cells; Cell Proliferation; Central Nervous System; | 2021 |
Modification of the natural progression of epileptogenesis by means of biperiden in the pilocarpine model of epilepsy.
Topics: Action Potentials; Animals; Autonomic Nervous System; Biperiden; Chronic Disease; Cytokines; Disease | 2017 |
Neurochemical abnormalities in premanifest and early spinocerebellar ataxias.
Topics: Activities of Daily Living; Adult; Aged; Aspartic Acid; Ataxins; Brain; Brain Diseases, Metabolic; C | 2018 |
GABA promotes gastrin-releasing peptide secretion in NE/NE-like cells: Contribution to prostate cancer progression.
Topics: Adenocarcinoma; Aged; Cohort Studies; Disease Progression; GABA Agents; gamma-Aminobutyric Acid; Gas | 2018 |
Epilepsy and brain injury: a case report of a dramatic neuropsychiatric vicious circle.
Topics: Accidents, Traffic; Aggression; Amines; Anterior Temporal Lobectomy; Anticonvulsants; Brain Injuries | 2013 |
Clinical characteristics and medication uses among fibromyalgia patients newly prescribed amitriptyline, duloxetine, gabapentin, or pregabalin.
Topics: Amines; Amitriptyline; Analgesics; Anti-Anxiety Agents; Antidepressive Agents; Cyclohexanecarboxylic | 2013 |
Effectiveness of pregabalin as monotherapy or combination therapy for neuropathic pain in patients unresponsive to previous treatments in a Spanish primary care setting.
Topics: Adult; Aged; Analgesics; Disease Progression; Drug Therapy, Combination; Female; gamma-Aminobutyric | 2013 |
Involvement of renal sympathetic nerve overactivation in the progression of chronic kidney disease in rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Autonom | 2014 |
Altered cortical expression of GABA-related genes in schizophrenia: illness progression vs developmental disturbance.
Topics: Adult; Animals; Calbindin 2; Case-Control Studies; Disease Progression; Female; GABA Plasma Membrane | 2015 |
Pre- and postsynaptic type-1 cannabinoid receptors control the alterations of glutamate transmission in experimental autoimmune encephalomyelitis.
Topics: Animals; Corpus Striatum; Disease Progression; Encephalomyelitis, Autoimmune, Experimental; Excitato | 2014 |
Interaction between interleukin-1 beta and angiotensin II receptor 1 in hypothalamic paraventricular nucleus contributes to progression of heart failure.
Topics: Animals; Corticotropin-Releasing Hormone; Disease Models, Animal; Disease Progression; gamma-Aminobu | 2014 |
Augmentation in restless legs syndrome patients in Korea.
Topics: Aged; Aged, 80 and over; Amines; Benzothiazoles; Cross-Sectional Studies; Cyclohexanecarboxylic Acid | 2015 |
Impact of pregabalin treatment on synaptic plasticity and glial reactivity during the course of experimental autoimmune encephalomyelitis.
Topics: Animals; Calcium-Binding Proteins; Cytokines; Disease Progression; Encephalomyelitis, Autoimmune, Ex | 2014 |
Combined diazepam and MK-801 therapy provides synergistic protection from tetramethylenedisulfotetramine-induced tonic-clonic seizures and lethality in mice.
Topics: Animals; Anticonvulsants; Brain Waves; Bridged-Ring Compounds; Central Nervous System; Diazepam; Dis | 2015 |
Gabapentin, an Analgesic Used Against Cancer-Associated Neuropathic Pain: Effects on Prostate Cancer Progression in an In Vivo Rat Model.
Topics: Amines; Analgesics; Animals; Carcinogenesis; Cells, Cultured; Cyclohexanecarboxylic Acids; Disease M | 2016 |
Decreased Expression of Sox-1 in Cerebellum of Rat with Generalized Seizures Induced by Kindling Model.
Topics: Amygdala; Animals; Blotting, Western; Cerebellum; Chromatography, High Pressure Liquid; Disease Mode | 2016 |
Early GABAergic transmission defects in the external globus pallidus and rest/activity rhythm alteration in a mouse model of Huntington's disease.
Topics: Aging; Animals; Disease Models, Animal; Disease Progression; gamma-Aminobutyric Acid; Globus Pallidu | 2016 |
Multilevel symmetric neuropathic pruritus (MSNP) presenting as recalcitrant "generalized" pruritus.
Topics: Age Distribution; Aged; Amines; Chronic Disease; Cohort Studies; Cyclohexanecarboxylic Acids; Diseas | 2016 |
A codon-optimized Mecp2 transgene corrects breathing deficits and improves survival in a mouse model of Rett syndrome.
Topics: Amines; Animals; Apnea; Codon; Cyclohexanecarboxylic Acids; Dependovirus; Disease Models, Animal; Di | 2017 |
Altered glutamate metabolism contributes to antiepileptogenic effects in the progression from focal seizure to generalized seizure by low-frequency stimulation in the ventral hippocampus.
Topics: Animals; Cerebral Cortex; Dentate Gyrus; Disease Progression; Electric Stimulation; gamma-Aminobutyr | 2017 |
Stiff eyes in stiff-person syndrome.
Topics: Autoantibodies; Diagnosis, Differential; Disease Progression; Electromyography; Female; gamma-Aminob | 2008 |
Pattern of injury with a graded excitotoxic insult and ensuing chronic medial septal damage in the rat brain.
Topics: Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Atroph | 2009 |
An uncommon paraneoplastic Ri-positive opsoclonus-myoclonus-like syndrome and stiff-person syndrome with elevated glutamate/GABA ratio in the cerebrospinal fluid after breast cancer.
Topics: Antigens, Neoplasm; Autoantibodies; Breast Neoplasms; Disease Progression; Female; gamma-Aminobutyri | 2010 |
Syringomyelia in the Cavalier King Charles spaniel (CKCS) dog.
Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents; Arnold-Chiari Malformation; Breeding; Cyclohe | 2010 |
Osseous metaplasia late in the course of nephrogenic systemic fibrosis.
Topics: Adult; Analgesics; Calcinosis; Disease Progression; Female; gamma-Aminobutyric Acid; Humans; Hydroxy | 2010 |
Differential GABAergic disinhibition during the development of painful peripheral neuropathy.
Topics: Animals; Cell Count; Disease Progression; gamma-Aminobutyric Acid; K Cl- Cotransporters; Male; Neura | 2011 |
Retinal remodeling in the Tg P347L rabbit, a large-eye model of retinal degeneration.
Topics: Adult; Animals; Animals, Genetically Modified; Disease Models, Animal; Disease Progression; Electror | 2011 |
The MAO inhibitor phenelzine improves functional outcomes in mice with experimental autoimmune encephalomyelitis (EAE).
Topics: Affect; Animals; Anterior Horn Cells; Brain Chemistry; Chromatography, High Pressure Liquid; Disease | 2011 |
Regulation of pancreatic cancer by neuropsychological stress responses: a novel target for intervention.
Topics: Animals; Cell Line, Tumor; Cyclic AMP; Disease Progression; Epinephrine; gamma-Aminobutyric Acid; Hu | 2012 |
Elevated pontine and putamenal GABA levels in mild-moderate Parkinson disease detected by 7 tesla proton MRS.
Topics: Case-Control Studies; Disease Progression; Female; gamma-Aminobutyric Acid; Humans; Magnetic Resonan | 2012 |
Reversible delirium in an advanced cancer patient.
Topics: Amines; Analgesics; Analgesics, Opioid; Bone Neoplasms; Breast Neoplasms; Carcinoma, Intraductal, No | 2012 |
γ-Aminobutyric acid (GABA) signalling in human pancreatic islets is altered in type 2 diabetes.
Topics: Diabetes Mellitus, Type 2; Disease Progression; Dose-Response Relationship, Drug; Down-Regulation; F | 2012 |
A 9-year follow-up of a girl with pyridoxine (vitamin B6)-dependent seizures: magnetic resonance spectroscopy findings.
Topics: Adolescent; Anticonvulsants; Aspartic Acid; Biomarkers; Brain; Child; Creatinine; Disease Progressio | 2012 |
Chronobiological characteristics of neuropathic pain: clinical predictors of diurnal pain rhythmicity.
Topics: Amines; Analgesics; Analysis of Variance; Circadian Rhythm; Cyclohexanecarboxylic Acids; Diabetic Ne | 2013 |
Astrocyte metabolism is disturbed in the early development of experimental hydrocephalus.
Topics: Acetates; Animals; Astrocytes; Biomarkers; Brain Stem; Carbon Isotopes; Disease Models, Animal; Dise | 2003 |
Rapid disease development in scrapie-infected mice deficient for CD40 ligand.
Topics: Alzheimer Disease; Animals; Biomarkers; Brain; CD40 Antigens; CD40 Ligand; Disease Progression; Fema | 2004 |
[Evidence-based management of diabetic polyneuropathy. "Burning feet" alarm signal].
Topics: Amines; Combined Modality Therapy; Cyclohexanecarboxylic Acids; Diabetic Foot; Diabetic Neuropathies | 2004 |
Oral treatment with PD-0200347, an alpha2delta ligand, reduces the development of experimental osteoarthritis by inhibiting metalloproteinases and inducible nitric oxide synthase gene expression and synthesis in cartilage chondrocytes.
Topics: Administration, Oral; Amines; Animals; Cartilage, Articular; Chondrocytes; Cyclohexanecarboxylic Aci | 2005 |
UCM707, an inhibitor of the anandamide uptake, behaves as a symptom control agent in models of Huntington's disease and multiple sclerosis, but fails to delay/arrest the progression of different motor-related disorders.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Arachidonic Acids; Brain Chemistry; D | 2006 |
Carbamazepine encephalopathy masquerading as Creutzfeldt-Jakob disease.
Topics: Aged; Amines; Analgesics, Non-Narcotic; Atrophy; Basal Ganglia; Brain; Brain Damage, Chronic; Carbam | 2005 |
Activation of Notch1 signaling is required for beta-catenin-mediated human primary melanoma progression.
Topics: Animals; beta Catenin; Cell Line; Cell Line, Tumor; Cell Proliferation; Chlorocebus aethiops; COS Ce | 2005 |
Stiff child syndrome with mutation of DYT1 gene.
Topics: Asian People; Autoantibodies; Child; Disease Progression; DNA Mutational Analysis; Dystonia; GABA Ag | 2005 |
Inosiplex affects the spectra of proton magnetic resonance spectroscopy in subacute sclerosing panencephalitis.
Topics: Adolescent; Antiviral Agents; Artifacts; Aspartic Acid; Choline; Disease Progression; Dominance, Cer | 2006 |
Gamma-aminobutyric acid specifically inhibits progression of tubular fibrosis and atrophy in nephrectomized rats.
Topics: Animals; Atrophy; Blood Urea Nitrogen; Creatinine; Disease Progression; Dose-Response Relationship, | 2007 |
Metabolic progression markers of neurodegeneration in the transgenic G93A-SOD1 mouse model of amyotrophic lateral sclerosis.
Topics: Age Factors; Amyotrophic Lateral Sclerosis; Analysis of Variance; Animals; Aspartic Acid; Disease Mo | 2007 |
Loss of Perineuronal Net in ME7 Prion Disease.
Topics: Animals; Disease Models, Animal; Disease Progression; Encephalitis; Extracellular Matrix; Female; ga | 2008 |
Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis.
Topics: Acetates; Amines; Amyotrophic Lateral Sclerosis; Animals; Brain; Cyclohexanecarboxylic Acids; Diet; | 1996 |
Severe, early and selective loss of a subpopulation of GABAergic inhibitory neurons in experimental transmissible spongiform encephalopathies.
Topics: Animals; Brain; Brain Chemistry; Disease Progression; gamma-Aminobutyric Acid; Histocytochemistry; M | 1998 |
Retinal degeneration in the nervous mutant mouse. IV. Inner retinal changes.
Topics: Animals; Apoptosis; Cell Count; Disease Progression; Electroretinography; gamma-Aminobutyric Acid; G | 2001 |
Inflammation-mediated damage in progressing lacunar infarctions: a potential therapeutic target.
Topics: Aged; Biomarkers; Brain Infarction; Disease Progression; Encephalitis; Female; gamma-Aminobutyric Ac | 2002 |