gamma-aminobutyric acid and Depressive Disorder studies

gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.

Depressive Disorder: An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.

Research Excerpts

Excerpt	Relevance	Reference
"To provide a qualitative, systematic update and review of the pharmacology, pharmacokinetics, efficacy in mood disorders, adverse effects, and costs of lamotrigine."	8.81	Lamotrigine update and its use in mood disorders. ( Hurley, SC, 2002)
"Gabapentin appears to be somewhat effective as add-on treatment in a subgroup of patients with mood disorders in a naturalistic setting."	7.70	Gabapentin treatment of mood disorders: a preliminary study. ( Desai, SP; Ghaemi, SN; Goodwin, FK; Katzow, JJ, 1998)
"Gabapentin was moderately to markedly effective in 30% (15/50) of patients, with statistically nonsignificant differences between patients with bipolar disorder type I, bipolar disorder type II and NOS, and unipolar major depressive disorder."	7.70	Gabapentin treatment of mood disorders: a preliminary study. ( Desai, SP; Ghaemi, SN; Goodwin, FK; Katzow, JJ, 1998)
"All charts of patients meeting DSM-IV criteria for bipolar disorder or unipolar major depressive disorder treated with gabapentin in a private psychiatric practice were reviewed and clinical response was assessed retrospectively using the Clinical Global Impressions scale for Improvement (CGI-I)."	7.70	Gabapentin treatment of mood disorders: a preliminary study. ( Desai, SP; Ghaemi, SN; Goodwin, FK; Katzow, JJ, 1998)
"To determine if gabapentin is effective either as adjunctive treatment or as monotherapy for major affective disorders in a naturalistic setting."	7.70	Gabapentin treatment of mood disorders: a preliminary study. ( Desai, SP; Ghaemi, SN; Goodwin, FK; Katzow, JJ, 1998)
" A slow upward dose titration is recommended to reduce the incidence of serious rash, but this may delay the attainment of adequate dosage for 6 weeks."	6.41	Lamotrigine update and its use in mood disorders. ( Hurley, SC, 2002)
"Lamotrigine has positive effects on cognitive function, but occasionally produces insomnia."	6.41	Lamotrigine update and its use in mood disorders. ( Hurley, SC, 2002)
"Depression is the disease of the modern era."	5.48	Behavioral effects of toll-like receptor-4 antagonist 'eritoran' in an experimental model of depression: role of prefrontal and hippocampal neurogenesis and γ-aminobutyric acid/glutamate balance. ( Aboul-Fotouh, S; Asaad, T; Ghanem, MH; Habib, M; Kassim, SK, 2018)
" We investigated the effect of long-term administration of ERI in three different doses on behavioral changes, hippocampal and prefrontal cortex (PFC) neurogenesis, and γ-aminobutyric acid (GABA)/glutamate balance in male Wistar rats exposed to chronic restraint stress (CRS)."	5.48	Behavioral effects of toll-like receptor-4 antagonist 'eritoran' in an experimental model of depression: role of prefrontal and hippocampal neurogenesis and γ-aminobutyric acid/glutamate balance. ( Aboul-Fotouh, S; Asaad, T; Ghanem, MH; Habib, M; Kassim, SK, 2018)
"Gabapentin was moderately to markedly effective in 30% (15/50) of patients, with statistically nonsignificant differences between patients with bipolar disorder type I, bipolar disorder type II and NOS, and unipolar major depressive disorder."	5.30	Gabapentin treatment of mood disorders: a preliminary study. ( Desai, SP; Ghaemi, SN; Goodwin, FK; Katzow, JJ, 1998)
"The aims of the present study were to investigate the main demographic and clinical characteristics, comorbidity patterns, use in association and tolerability of pregabalin in a sample of patients with affective disorders, and to compare demographic and clinical variables of the groups divided, according to the treatment pregabalin was associated with."	5.16	Tolerability and use in co-administration of pregabalin in affective patients: a 6-month prospective naturalistic study. ( Altamura, AC; Arici, C; Buoli, M; Camuri, G; Dell'Osso, B; Dobrea, C, 2012)
"One hundred and fourteen consecutive outpatients, with anxiety and/or depressive disorders with or without comorbidity, were started on pregabalin, assessed and interviewed and their demographic data, associated therapy, tolerability and side effects collected over an observational period of 6 months."	5.16	Tolerability and use in co-administration of pregabalin in affective patients: a 6-month prospective naturalistic study. ( Altamura, AC; Arici, C; Buoli, M; Camuri, G; Dell'Osso, B; Dobrea, C, 2012)
"To provide a qualitative, systematic update and review of the pharmacology, pharmacokinetics, efficacy in mood disorders, adverse effects, and costs of lamotrigine."	4.81	Lamotrigine update and its use in mood disorders. ( Hurley, SC, 2002)
"Considerable evidence implicates the neurotransmitter gamma-aminobutyric acid (GABA) in the biochemical pathophysiology of mood disorders."	4.79	GABA and mood disorders: a brief review and hypothesis. ( Petty, F, 1995)
"Major depressive disorder is a stress-related disease associated with brain metabolic dysregulation in the glutamine-glutamate/γ-aminobutyric acid (Gln-Glu/GABA) cycle."	3.96	Dietary supplementation with Lactobacillus rhamnosus JB-1 restores brain neurochemical balance and mitigates the progression of mood disorder in a rat model of chronic unpredictable mild stress. ( Andres-Mach, M; Chudzik, A; Kochalska, K; Kozioł, P; Oakden, W; Orzylowska, A; Pankowska, A; Pietura, R; Rola, R; Stanisz, GJ; Słowik, T; Łazorczyk, A, 2020)
" This protocol was validated by determining the postmortem cerebrospinal fluid (CSF) glutamic acid (Glu) and γ-aminobutyric acid (GABA) levels of 8 major depressive disorder (MDD) patients, 9 bipolar disorder (BD) patients, and 19 well-matched controls, while also testing the plasma and CSF AA levels of living MDD patients."	3.83	A sensitive and practical RP-HPLC-FLD for determination of the low neuroactive amino acid levels in body fluids and its application in depression. ( Bao, AM; Wu, JL; Wu, SH; Yu, SY, 2016)
"An [1H]-MRS was used to measure levels of GABA, of the combined concentration of Glu and glutamine (Gln), and of N-acetylaspartate (NAA) in occipital cortex in medication-free, fully recovered subjects with a history of recurrent unipolar depression (n = 15), bipolar disorder (n = 16), and a group of healthy controls (n = 18)."	3.74	Reduction in occipital cortex gamma-aminobutyric acid concentrations in medication-free recovered unipolar depressed and bipolar subjects. ( Ashworth, F; Bhagwagar, Z; Cowen, PJ; Evans, J; Jezzard, P; Matthews, PM; Sule, A; Wylezinska, M, 2007)
"To determine if gabapentin is effective in monotherapy or add-on treatment of non-refractory bipolar disorder in open prospective treatment."	3.71	Gabapentin treatment of the non-refractory bipolar spectrum: an open case series. ( Ghaemi, SN; Goodwin, FK, 2001)
"A chart review was conducted on 27 outpatients presenting with a depressive disorder in whom gabapentin was added to ongoing treatment with a conventional antidepressant to which patients had not responded after at least 6 weeks."	3.71	Adjunctive gabapentin in treatment-resistant depression: a retrospective chart review. ( Carpenter, LL; Leon, Z; Price, LH; Siniscalchi, JM; Yasmin, S, 2001)
"Gabapentin was moderately to markedly effective in 30% (15/50) of patients, with statistically nonsignificant differences between patients with bipolar disorder type I, bipolar disorder type II and NOS, and unipolar major depressive disorder."	3.70	Gabapentin treatment of mood disorders: a preliminary study. ( Desai, SP; Ghaemi, SN; Goodwin, FK; Katzow, JJ, 1998)
"Gabapentin appears to be somewhat effective as add-on treatment in a subgroup of patients with mood disorders in a naturalistic setting."	3.70	Gabapentin treatment of mood disorders: a preliminary study. ( Desai, SP; Ghaemi, SN; Goodwin, FK; Katzow, JJ, 1998)
"All charts of patients meeting DSM-IV criteria for bipolar disorder or unipolar major depressive disorder treated with gabapentin in a private psychiatric practice were reviewed and clinical response was assessed retrospectively using the Clinical Global Impressions scale for Improvement (CGI-I)."	3.70	Gabapentin treatment of mood disorders: a preliminary study. ( Desai, SP; Ghaemi, SN; Goodwin, FK; Katzow, JJ, 1998)
"To determine if gabapentin is effective either as adjunctive treatment or as monotherapy for major affective disorders in a naturalistic setting."	3.70	Gabapentin treatment of mood disorders: a preliminary study. ( Desai, SP; Ghaemi, SN; Goodwin, FK; Katzow, JJ, 1998)
"Plasma gamma-aminobutyric acid (GABA) levels have been reported to be low in some patients with major depressive disorder."	3.69	Low plasma gamma-aminobutyric acid levels during the late luteal phase of women with premenstrual dysphoric disorder. ( Bibi, KW; Halbreich, U; Kramer, GL; Petty, F; Rush, AJ; Yonkers, K, 1996)
"Plasma levels of gamma-aminobutyric acid (GABA) were significantly lower in males with primary unipolar major depressive disorder than in healthy controls."	3.68	Low plasma gamma-aminobutyric acid levels in male patients with depression. ( Gullion, CM; Kramer, GL; Petty, F; Rush, AJ, 1992)
"Depression is the second leading cause of disability in the world population, for which currently available pharmacological therapies either have poor efficacy or have some adverse effects."	3.01	Altered neurotransmission in stress-induced depressive disorders: The underlying role of the amygdala in depression. ( Asim, M; Wang, H; Waris, A, 2023)
"Forty adult patients with partial epilepsy were studied in a prospective, non-randomized fashion with interviewer-rated and self-rated scales of mood and anxiety: the Cornell Dysthymia Rating Scale (CDRS), Beck Depression Inventory (BDI), and Hamilton Depression (Ham-D) and Anxiety (Ham-A) Scales."	2.69	A beneficial effect on mood in partial epilepsy patients treated with gabapentin. ( Carson, D; Goldstein, MA; Harden, CL; Kocsis, JH; Labar, DR; Lazar, LM; Nikolov, B; Pick, LH; Ravdin, LD, 1999)
"Progabide was devoid of any evident antipsychotic action."	2.65	The potential use of GABA agonists in psychiatric disorders: evidence from studies with progabide in animal models and clinical trials. ( Bartholini, G; Broekkamp, C; Depoortere, H; Fournier, V; Lloyd, KG; Morselli, PL; Scatton, B; Worms, P; Zivkovic, B, 1983)
"Major depressive disorder has recently been characterized by abnormal resting state hyperactivity in anterior midline regions."	2.46	Is subcortical-cortical midline activity in depression mediated by glutamate and GABA? A cross-species translational approach. ( Alcaro, A; Hayes, DJ; Northoff, G; Panksepp, J; Witczak, J, 2010)
" Preclinical studies demonstrate that GABA modulating agents are active in commonly used rodent behavioral models of antidepressant activity, and that chronic administration of antidepressant drugs induces marked changes in GABAergic function."	2.44	GABAergic contributions to the pathophysiology of depression and the mechanism of antidepressant action. ( Sanacora, G; Saricicek, A, 2007)
" A slow upward dose titration is recommended to reduce the incidence of serious rash, but this may delay the attainment of adequate dosage for 6 weeks."	2.41	Lamotrigine update and its use in mood disorders. ( Hurley, SC, 2002)
"Lamotrigine has positive effects on cognitive function, but occasionally produces insomnia."	2.41	Lamotrigine update and its use in mood disorders. ( Hurley, SC, 2002)
"Vigabatrin (VGB) is a structural analogue of the inhibitory neurotransmitter gamma-amino butyric acid (GABA), which produces its antiepileptic effect by irreversibly inhibiting the degradative enzyme GABA-transaminase."	2.40	Vigabatrin. ( French, JA, 1999)
"Major depressive disorder is a stress-related disease associated with brain metabolic dysregulation in the glutamine-glutamate/γ-aminobutyric acid (Gln-Glu/GABA) cycle."	1.56	Dietary supplementation with Lactobacillus rhamnosus JB-1 restores brain neurochemical balance and mitigates the progression of mood disorder in a rat model of chronic unpredictable mild stress. ( Andres-Mach, M; Chudzik, A; Kochalska, K; Kozioł, P; Oakden, W; Orzylowska, A; Pankowska, A; Pietura, R; Rola, R; Stanisz, GJ; Słowik, T; Łazorczyk, A, 2020)
"Depression affects approximately 5% of elderly people and its etiology might be related to chronic stress exposure during neurodevelopmental periods."	1.51	Adolescent stress increases depression-like behaviors and alters the excitatory-inhibitory balance in aged mice. ( Li, JT; Liu, X; Ma, YN; Si, TM; Su, YA; Sun, YX; Wang, H; Wang, HL, 2019)
"Depression is the disease of the modern era."	1.48	Behavioral effects of toll-like receptor-4 antagonist 'eritoran' in an experimental model of depression: role of prefrontal and hippocampal neurogenesis and γ-aminobutyric acid/glutamate balance. ( Aboul-Fotouh, S; Asaad, T; Ghanem, MH; Habib, M; Kassim, SK, 2018)
" We investigated the effect of long-term administration of ERI in three different doses on behavioral changes, hippocampal and prefrontal cortex (PFC) neurogenesis, and γ-aminobutyric acid (GABA)/glutamate balance in male Wistar rats exposed to chronic restraint stress (CRS)."	1.48	Behavioral effects of toll-like receptor-4 antagonist 'eritoran' in an experimental model of depression: role of prefrontal and hippocampal neurogenesis and γ-aminobutyric acid/glutamate balance. ( Aboul-Fotouh, S; Asaad, T; Ghanem, MH; Habib, M; Kassim, SK, 2018)
"Fifty-eight percent had an opioid use disorder, again mostly in combination with other drugs and/or alcohol."	1.43	Abuse of Gabapentin is Associated with Opioid Addiction. ( Bastiaens, L; Galus, J; Mazur, C, 2016)
"All patients had substance use disorders, the large majority (72 %) to more than one substance."	1.43	Abuse of Gabapentin is Associated with Opioid Addiction. ( Bastiaens, L; Galus, J; Mazur, C, 2016)
"Thirty patients with atypical facial pain were treated with noophen."	1.42	[Emotional and personality disorders in atypical facial pain]. ( Maximova, MY; Suanova, ET, 2015)
"Depression is a complex neuropsychiatric syndrome that is often very severe and life threatening."	1.40	Dysfunctional glutamatergic and γ-aminobutyric acidergic activities in prefrontal cortex of mice in social defeat model of depression. ( Bagga, P; Chakravarty, S; Khandelwal, N; Kumar, A; Maitra, S; Noronha, JM; Patel, AB; Veeraiah, P, 2014)
"We studied 14 chronic migraine patients, with or without depression, compared to age-and sex-matched controls."	1.33	Cerebrospinal fluid GABA levels in chronic migraine with and without depression. ( Alonso, EO; Cavalheiro, EA; Faulhaber, MH; Naffah-Mazacoratti, MG; Peres, MF; Senne Soares, CA; Vieira, DS; Zukerman, E, 2006)
" The experiments demonstrate that the most consistent finding following chronic administration of antidepressants is an increase in GABAB receptor function, with or without a change in receptor binding or subunit expression."	1.33	GABAergic hypotheses of anxiety and depression: focus on GABA-B receptors. ( Nowak, G; Pilc, A, 2005)
"Reboxetine is a selective norepinephrine (NE) reuptake inhibitor that exerts significant antidepressant action."	1.32	Norepinephrine-gamma-aminobutyric acid (GABA) interaction in limbic stress circuits: effects of reboxetine on GABAergic neurons. ( Bodie, B; Herman, JP; Renda, A, 2003)
"Gabapentin was associated with a 43."	1.31	Gabapentin treatment of the non-refractory bipolar spectrum: an open case series. ( Ghaemi, SN; Goodwin, FK, 2001)
"Gabapentin was well tolerated; the most common adverse effects were fatigue, sedation, dizziness, and gastrointestinal symptoms."	1.31	Adjunctive gabapentin in treatment-resistant depression: a retrospective chart review. ( Carpenter, LL; Leon, Z; Price, LH; Siniscalchi, JM; Yasmin, S, 2001)
"Total sleep deprivation (TSD) is an efficient method to relieve depression."	1.31	Increase in amino acids in the pons after sleep deprivation: a pilot study using proton magnetic resonance spectroscopy. ( Auer, DP; Czisch, M; Murck, H; Steiger, A; Struttmann, T; Wetter, T, 2002)
"Gabapentin was moderately to markedly effective in 30% (15/50) of patients, with statistically nonsignificant differences between patients with bipolar disorder type I, bipolar disorder type II and NOS, and unipolar major depressive disorder."	1.30	Gabapentin treatment of mood disorders: a preliminary study. ( Desai, SP; Ghaemi, SN; Goodwin, FK; Katzow, JJ, 1998)
"Patients with unipolar depression who received a dexamethasone suppression test had no correlation between nonsuppression of cortisol secretion and plasma levels of GABA."	1.27	Plasma GABA levels in psychiatric illness. ( Petty, F; Sherman, AD, 1984)
"Fengabine (SL 79."	1.27	Fengabine, a novel antidepressant GABAergic agent. I. Activity in models for antidepressant drugs and psychopharmacological profile. ( Bartholini, G; Depoortere, H; Lloyd, KG; Sanger, D; Zivkovic, B, 1987)

Research

Studies (132)

Authors

Clinical Trials (10)

Trial Overview

Trial Outcomes

Prefrontal GABA+ Concentrations

Timeframe	Studies, this research(%)	All Research%
pre-1990	31 (23.48)	18.7374
1990's	29 (21.97)	18.2507
2000's	29 (21.97)	29.6817
2010's	35 (26.52)	24.3611
2020's	8 (6.06)	2.80

Authors	Studies
Davydova, TV	1
Nevidimova, TI	1
Vetrile, LA	1
Zakharova, IA	1
Savochkina, DN	1
Galkin, SA	1
Bokhan, NA	1
Asim, M	1
Wang, H	4
Waris, A	1
Yan, LD	1
Zhou, P	1
Lai, MQ	1
Wu, M	1
Zhang, Y	2
Tang, RD	1
Sun, R	1
Luo, Y	1
Li, M	2
Sun, JL	1
Fu, WB	1
Sun, X	1
Wang, Z	1
Li, Y	1
Ma, K	1
Zhang, H	1
Wang, S	2
Wang, Y	1
Liu, J	1
Song, X	1
Dong, Z	1
Han, X	1
Li, H	1
Rahaman, A	1
Baloch, Z	1
Wang, Q	1
Dwivedi, Y	1
Korczak, M	1
Kurowski, P	1
Leśniak, A	1
Grönbladh, A	1
Filipowska, A	1
Bujalska-Zadrożny, M	1
Kochalska, K	1
Oakden, W	1
Słowik, T	1
Chudzik, A	1
Pankowska, A	1
Łazorczyk, A	1
Kozioł, P	1
Andres-Mach, M	1
Pietura, R	1
Rola, R	1
Stanisz, GJ	1
Orzylowska, A	1
Xia, G	1
Han, Y	1
Meng, F	1
He, Y	1
Srisai, D	1
Farias, M	1
Dang, M	1
Palmiter, RD	1
Xu, Y	1
Wu, Q	1
Lukkes, JL	1
Meda, S	1
Thompson, BS	1
Freund, N	1
Andersen, SL	1
Qiuxia, Z	1
Xinlong, M	1
Yilong, Y	1
Hui, Z	1
Yali, W	1
Xiaoquan, Y	1
Lei, W	1
Jiahui, C	1
Haiyan, Z	1
Ghosal, S	1
Bang, E	1
Yue, W	1
Hare, BD	1
Lepack, AE	1
Girgenti, MJ	1
Duman, RS	2
Aboul-Fotouh, S	1
Habib, M	1
Asaad, T	1
Kassim, SK	1
Ghanem, MH	1
Zalar, B	1
Haslberger, A	1
Peterlin, B	1
Zhang, C	2
Kalueff, AV	2
Song, C	1
Konen, C	1
Niederst, E	1
Sanacora, G	6
Krystal, JH	5
Wang, HL	1
Sun, YX	1
Liu, X	2
Ma, YN	1
Su, YA	1
Li, JT	1
Si, TM	1
Veeraiah, P	1
Noronha, JM	1
Maitra, S	1
Bagga, P	1
Khandelwal, N	1
Chakravarty, S	1
Kumar, A	1
Patel, AB	1
Anderson, C	1
George, D	1
Quante, A	1
Huang, F	1
Li, J	1
Shi, HL	1
Wang, TT	1
Muhtar, W	1
Du, M	1
Zhang, BB	1
Wu, H	1
Yang, L	1
Hu, ZB	1
Wu, XJ	1
Northoff, G	2
Sibille, E	1
Medvedev, VE	1
Frolova, VI	1
Epifanov, AV	1
Shao, B	1
Zhou, YL	1
Lin, YS	1
Gordon, JL	2
Girdler, SS	2
Meltzer-Brody, SE	2
Stika, CS	2
Thurston, RC	2
Clark, CT	2
Prairie, BA	2
Moses-Kolko, E	2
Joffe, H	2
Wisner, KL	2
Jiménez-Sánchez, L	1
Castañé, A	1
Pérez-Caballero, L	1
Grifoll-Escoda, M	1
López-Gil, X	1
Campa, L	1
Galofré, M	1
Berrocoso, E	1
Adell, A	1
Eskola, PJ	1
Jokelainen, J	1
Järvelin, MR	1
Keinänen-Kiukaanniemi, S	1
Ruokonen, A	1
Puukka, K	1
Timonen, M	1
Auvinen, JP	1
Benson, C	1
Mifflin, K	1
Kerr, B	1
Jesudasan, SJ	1
Dursun, S	1
Baker, G	1
Wu, JL	1
Yu, SY	1
Wu, SH	1
Bao, AM	1
Bastiaens, L	1
Galus, J	1
Mazur, C	1
Maximova, MY	1
Suanova, ET	1
Roboon, J	1
Nudmamud-Thanoi, S	1
Thanoi, S	1
Song, MX	1
Rao, BQ	1
Cheng, BB	1
Wu, Y	1
Zeng, H	1
Luo, YG	1
Deng, XQ	1
Abdelkader, NF	1
Saad, MA	1
Abdelsalam, RM	1
Yuan, TF	1
Sümegi, A	1
Kato, N	1
Heinisch, S	1
Kirby, LG	1
Lee, CH	1
Hwang, IK	1
Choi, JH	1
Yoo, KY	1
Han, TH	1
Park, OK	1
Lee, SY	1
Ryu, PD	1
Won, MH	1
Alcaro, A	1
Panksepp, J	1
Witczak, J	1
Hayes, DJ	1
Taylor, MJ	1
Mannie, ZN	1
Norbury, R	1
Near, J	1
Cowen, PJ	3
Paslakis, G	1
Gilles, M	1
Deuschle, M	1
Karaiskos, D	1
Pappa, D	1
Tzavellas, E	1
Siarkos, K	1
Katirtzoglou, E	1
Papadimitriou, GN	1
Politis, A	1
Dobrea, C	1
Buoli, M	1
Arici, C	1
Camuri, G	1
Dell'Osso, B	1
Altamura, AC	1
Bondarenko, II	1
Kissin, MIa	1
Herman, JP	1
Renda, A	1
Bodie, B	1
Mason, GF	3
Rothman, DL	3
Hyder, F	2
Ciarcia, JJ	1
Ostroff, RB	1
Berman, RM	2
Chang, L	1
Cloak, CC	1
Ernst, T	1
Tunnicliff, G	1
Malatynska, E	1
RUSCAK, M	1
Leung, JW	1
Xue, H	1
Jankowski, MP	1
Sesack, SR	1
Gueorguieva, R	1
Epperson, CN	1
Wu, YT	1
Appel, M	1
Yatham, LN	1
Kendell, SF	1
Howland, RH	1
Pilc, A	1
Nowak, G	1
Vieira, DS	1
Naffah-Mazacoratti, MG	1
Zukerman, E	1
Senne Soares, CA	1
Alonso, EO	1
Faulhaber, MH	1
Cavalheiro, EA	1
Peres, MF	1
Paige, LA	1
Mitchell, MW	1
Krishnan, KR	1
Kaddurah-Daouk, R	1
Steffens, DC	1
Nutt, DJ	2
Liu, GX	1
Cai, GQ	1
Cai, YQ	1
Sheng, ZJ	1
Jiang, J	1
Mei, Z	1
Wang, ZG	1
Guo, L	1
Fei, J	1
Cremers, TI	1
Rea, K	1
Bosker, FJ	1
Wikström, HV	1
Hogg, S	1
Mørk, A	1
Westerink, BH	1
Bhagwagar, Z	2
Wylezinska, M	1
Jezzard, P	1
Evans, J	1
Ashworth, F	1
Sule, A	1
Matthews, PM	1
Saricicek, A	1
Bartholini, G	6
Sherman, AD	2
Petty, F	13
Wunderlich, H	1
Wunderlich, HP	1
Lapierre, YD	1
Gerner, RH	3
Cohen, DJ	2
Fairbanks, L	2
Anderson, GM	2
Young, JG	2
Scheinin, M	2
Linnoila, M	4
Shaywitz, BA	2
Hare, TA	4
Lerer, B	2
Belmaker, RH	1
Sackeim, HA	3
Decina, P	2
Prohovnik, I	2
Malitz, S	2
Resor, SR	1
Lloyd, KG	7
Morselli, PL	4
Depoortere, H	2
Fournier, V	1
Zivkovic, B	6
Scatton, B	4
Broekkamp, C	1
Worms, P	1
Bracha, HS	1
Kleinman, JE	1
Maier, SF	1
Berrettini, WH	1
Nurnberger, JI	1
Simmons-Alling, S	1
Gershon, ES	1
Post, RM	2
Schlesser, MA	1
Kasa, K	1
Otsuki, S	1
Yamamoto, M	1
Sato, M	1
Kuroda, H	1
Ogawa, N	1
Kramer, GL	7
Fulton, M	3
Davis, L	1
Rush, AJ	6
Devanand, DP	1
Shapira, B	1
Kramer, G	1
Fitzsimons, L	1
Skolnick, AA	1
Manack, L	1
Steinberg, J	1
Moeller, FG	2
Krupitsky, EM	2
Burakov, AM	2
Ivanov, VB	1
Krandashova, GF	1
Lapin, IP	1
Trivedi, MH	1
Halbreich, U	1
Yonkers, K	1
Bibi, KW	1
Davis, LL	2
Kabel, D	1
Trivedi, M	1
Orsulak, PJ	1
Akers, L	1
Yonkers, KA	1
Ghaemi, SN	2
Katzow, JJ	1
Desai, SP	1
Goodwin, FK	3
Harden, CL	1
Lazar, LM	1
Pick, LH	1
Nikolov, B	1
Goldstein, MA	1
Carson, D	1
Ravdin, LD	1
Kocsis, JH	1
Labar, DR	1
Manber, R	1
Armitage, R	1
French, JA	1
Behar, KL	1
Petroff, OA	1
Charney, DS	1
Maurer, I	1
Volz, HP	1
Sauer, H	1
Yasmin, S	1
Carpenter, LL	1
Leon, Z	1
Siniscalchi, JM	1
Price, LH	1
Bjork, JM	1
Kram, M	1
Suris, A	1
Robillard, M	1
Conn, D	1
Hurley, SC	1
Murck, H	1
Struttmann, T	1
Czisch, M	1
Wetter, T	1
Steiger, A	1
Auer, DP	1
Arranz, B	1
Cowburn, R	1
Eriksson, A	1
Vestling, M	1
Marcusson, J	2
Gullion, CM	1
Caldecott-Hazard, S	1
Morgan, DG	1
DeLeon-Jones, F	1
Overstreet, DH	1
Janowsky, D	1
Roy, A	4
Dejong, J	3
Ferraro, T	2
Sherif, F	1
Oreland, L	1
Lamparski, D	1
George, T	1
Karandashova, GF	1
Lebedev, VP	1
Meltzer, HY	1
Pichat, P	2
Monteleone, P	2
Steardo, L	2
Tanzillo, C	1
Maj, M	2
Iovino, M	1
Thaker, GK	1
Moran, M	1
Tamminga, CA	1
Francis, PT	1
Poynton, A	1
Lowe, SL	1
Najlerahim, A	1
Bridges, PK	1
Bartlett, JR	1
Procter, AW	1
Bruton, CJ	1
Bowen, DM	1
Adinoff, B	1
Gold, P	1
Rubinow, D	1
Paul, SM	2
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Cheetham, SC	1
Crompton, MR	1
Katona, CL	1
Horton, RW	1
Rubinow, DR	1
Gold, PW	1
Ballenger, JC	1
Reichlin, S	1
Perrault, G	1
Jesberger, JA	1
Richardson, JS	1
Barbaccia, ML	1
Costa, E	1
Ferrero, P	1
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Trial	Phase	Enrollment	Study Type	Start Date	Status
Assessment of Efficacy and Safety of Anodal Transcranial Direct Current Stimulation (TDCS) in Pediatric and Teenage Patients With Major Depressive Disorder During COVID-19 Pandemics[NCT04780152]	Phase 2/Phase 3	172 participants (Anticipated)	Interventional	2021-10-31	Recruiting
A Randomised Controlled Trial Evaluating the Efficacy and Mechanisms of a Ketogenic Diet as an Adjunctive Treatment for People With Treatment-resistant Depression[NCT06091163]		100 participants (Anticipated)	Interventional	2024-01-31	Not yet recruiting
Treating Refractory Major Depressive Disorder With Repetitive Transcranial Magnetic Stimulation: A Double-blind, Sham-controlled, Longitudinal Study.[NCT00305045]		73 participants (Actual)	Interventional	2005-03-31	Completed
Remote Effects of Stroke on Cerebral Metabolism. Evaluation With Positron Emission Tomography and Proton Magnetic Resonance Spectroscopy[NCT00063180]		70 participants	Observational	2003-06-19	Completed
Effects of Intraoperative Low-dose Ketamine on Incidence of Postpartum Depression in Parturients With Prenatal Depression Undergoing Cesarean Delivery: Blind Test, Randomized, Placebo-controlled Trial[NCT03336541]	Phase 4	64 participants (Actual)	Interventional	2017-11-23	Completed
A Randomized Controlled Trial to Decrease Suicidal Thinking Using Ketamine[NCT02418702]	Phase 3	0 participants (Actual)	Interventional	2016-08-31	Withdrawn (stopped due to PI no longer at facility.)
Mood Disorder Cohort Research Consortium (MDCRC) in Korea[NCT03088657]		500 participants (Anticipated)	Observational [Patient Registry]	2015-09-30	Recruiting
Role of the Gut Microbiome as Determinant of Depression in Multiple Sclerosis Subjects[NCT05808101]		120 participants (Anticipated)	Observational	2022-01-27	Recruiting
Imaging Framework for Testing GABAergic/Glutamatergic Drugs in Bipolar Alcoholics[NCT03220776]	Phase 2	54 participants (Actual)	Interventional	2017-08-07	Completed
Measurement of GABA and Neurosteroid Levels in Women With Menopausal Major Depression Before and After Treatment With Estrogen Alone, Fluoxetine Alone, or Estrogen and Fluoxetine and Normal Controls Before and After Treatment With Estrogen[NCT00626340]	Phase 4	18 participants (Actual)	Interventional	1999-07-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Concentrations of GABA+, referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy (i.e., MEGA-PRESS). (NCT03220776)
Timeframe: Day 5 of each experimental condition

Prefrontal Glx Concentrations

Intervention	mmol/kg (Mean)
N-Acetylcysteine	3.90
Gabapentin	3.93
Placebo Oral Tablet	3.73

Concentrations of Glx (i.e., glutamate + glutamine), referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy. (NCT03220776)
Timeframe: Day 5 of each experimental condition

Comparison of Cortical GABA Levels in 4 Groups of Subjects Using Estrogen Alone, Fluoxetine Alone, Estrogen and Fluoxetine Combined in Pre and Post 4.0T Magnetic Resonance Spectroscopy Sessions.

Intervention	mmol/kg (Mean)
N-Acetylcysteine	21.59
Gabapentin	21.69
Placebo Oral Tablet	22.25

"This study was conducted at Yale University almost two decades ago. Our group at the University of Pennsylvania only has very basic information about this study. This includes the number of participants, which was 18, and the fact that no adverse events occurred. Staff members at the University of Pennsylvania do not have access to any additional study data. The contact person who initially entered this study protocol information is no longer at the University of Pennsylvania and we are unable to contact for additional information.~We only know that 18 participants completed, but as far as we know data was never analyzed for these 18 participants." (NCT00626340)
Timeframe: Healthy controls will undergo scans pre and post 3 weeks of estrogen treatment. Women with depression will undergo scans pre and post 6 weeks of treatment with estrogen alone, estrogen and fluoxetine, or fluoxetine alone

Article	Year
Altered neurotransmission in stress-induced depressive disorders: The underlying role of the amygdala in depression. Neuropeptides, 2023, Volume: 98 Topics: Amygdala; Cholecystokinin; Depression; Depressive Disorder; gamma-Aminobutyric Acid; Humans; Synapti	2023
Advances in novel molecular targets for antidepressants. Progress in neuro-psychopharmacology & biological psychiatry, 2021, 01-10, Volume: 104 Topics: Antidepressive Agents; Brain; Depressive Disorder; Drug Discovery; gamma-Aminobutyric Acid; Glutamic	2021
GABA European journal of pharmacology, 2020, Oct-15, Volume: 885 Topics: Animals; Antidepressive Agents; Depressive Disorder; gamma-Aminobutyric Acid; Humans; Intracellular	2020
The Role of Microbiota in Depression - a brief review. Psychiatria Danubina, 2018, Volume: 30, Issue:2 Topics: 3-Hydroxybutyric Acid; Acylation; Brain; Butyrates; Depressive Disorder; DNA Methylation; Emotions;	2018
Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments. Neuron, 2019, 04-03, Volume: 102, Issue:1 Topics: Animals; Antidepressive Agents; Brain; Cerebral Cortex; Depressive Disorder; gamma-Aminobutyric Acid	2019
Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments. Neuron, 2019, 04-03, Volume: 102, Issue:1 Topics: Animals; Antidepressive Agents; Brain; Cerebral Cortex; Depressive Disorder; gamma-Aminobutyric Acid	2019
Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments. Neuron, 2019, 04-03, Volume: 102, Issue:1 Topics: Animals; Antidepressive Agents; Brain; Cerebral Cortex; Depressive Disorder; gamma-Aminobutyric Acid	2019
Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments. Neuron, 2019, 04-03, Volume: 102, Issue:1 Topics: Animals; Antidepressive Agents; Brain; Cerebral Cortex; Depressive Disorder; gamma-Aminobutyric Acid	2019
Ovarian hormone fluctuation, neurosteroids, and HPA axis dysregulation in perimenopausal depression: a novel heuristic model. The American journal of psychiatry, 2015, Mar-01, Volume: 172, Issue:3 Topics: Depressive Disorder; Female; gamma-Aminobutyric Acid; Gonadal Hormones; Humans; Hypothalamo-Hypophys	2015
Biogenic Amines and the Amino Acids GABA and Glutamate: Relationships with Pain and Depression. Modern trends in pharmacopsychiatry, 2015, Volume: 30 Topics: Biogenic Amines; Chronic Pain; Depressive Disorder; gamma-Aminobutyric Acid; Glutamic Acid; Humans	2015
[Mood stabilizers--past, present and future]. Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology, 2008, Volume: 10, Issue:1 Topics: Affect; Antimanic Agents; Bipolar Disorder; Calcium; Carbamazepine; Depressive Disorder; gamma-Amino	2008
Neurophysiological mechanisms of electroconvulsive therapy for depression. Neuroscience research, 2009, Volume: 64, Issue:1 Topics: Animals; Brain; Carrier Proteins; Depressive Disorder; Electroconvulsive Therapy; gamma-Aminobutyric	2009
Is subcortical-cortical midline activity in depression mediated by glutamate and GABA? A cross-species translational approach. Neuroscience and biobehavioral reviews, 2010, Volume: 34, Issue:4 Topics: Animals; Brain; Depressive Disorder; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Species Specifi	2010
Magnetic resonance spectroscopy studies of GABA in neuropsychiatric disorders. The Journal of clinical psychiatry, 2003, Volume: 64 Suppl 3 Topics: Anxiety Disorders; Brain; Brain Chemistry; Creatine; Depressive Disorder; Epilepsy; GABA Agents; gam	2003
Central GABAergic systems and depressive illness. Neurochemical research, 2003, Volume: 28, Issue:6 Topics: Animals; Antidepressive Agents; Brain; Depressive Disorder; Disease Models, Animal; gamma-Aminobutyr	2003
GABAergic functions and depression: from classical therapies to herbal medicine. Current drug targets. CNS and neurological disorders, 2003, Volume: 2, Issue:6 Topics: Animals; Antidepressive Agents; Depressive Disorder; GABA Agents; gamma-Aminobutyric Acid; Humans; P	2003
Newer anticonvulsants in the treatment of bipolar disorder. The Journal of clinical psychiatry, 2004, Volume: 65 Suppl 10 Topics: Acetates; Amines; Anticonvulsants; Bipolar Disorder; Carbamazepine; Cyclohexanecarboxylic Acids; Dep	2004
GABA and glutamate systems as therapeutic targets in depression and mood disorders. Expert opinion on therapeutic targets, 2005, Volume: 9, Issue:1 Topics: Animals; Antidepressive Agents; Depressive Disorder; Drug Delivery Systems; Excitatory Amino Acid An	2005
Anticonvulsant drug therapies. Journal of psychosocial nursing and mental health services, 2005, Volume: 43, Issue:6 Topics: Amines; Anticonvulsants; Bipolar Disorder; Carbamazepine; Cyclohexanecarboxylic Acids; Depressive Di	2005
Role of GABA in anxiety and depression. Depression and anxiety, 2007, Volume: 24, Issue:7 Topics: Animals; Anxiety Disorders; Brain; Depressive Disorder; Diagnostic Imaging; Disease Models, Animal;	2007
GABAergic contributions to the pathophysiology of depression and the mechanism of antidepressant action. CNS & neurological disorders drug targets, 2007, Volume: 6, Issue:2 Topics: Affect; Animals; Antidepressive Agents; Depressive Disorder; Excitatory Amino Acid Agonists; Excitat	2007
'It's not over when it's over': persistent neurobiological abnormalities in recovered depressed patients. Psychological medicine, 2008, Volume: 38, Issue:3 Topics: Acute Disease; Depressive Disorder; Dexamethasone; Electroconvulsive Therapy; gamma-Aminobutyric Aci	2008
Anticonvulsant and antidepressant properties of electroconvulsive therapy: a proposed mechanism of action. Biological psychiatry, 1983, Volume: 18, Issue:11 Topics: Animals; Brain; Depressive Disorder; Electroconvulsive Therapy; Epilepsy; gamma-Aminobutyric Acid; H	1983
Postmortem studies in psychiatry. The Psychiatric clinics of North America, 1984, Volume: 7, Issue:3 Topics: Alcoholism; Alzheimer Disease; Brain Chemistry; Cholecystokinin; Depressive Disorder; Dopamine; Endo	1984
Learned helplessness and animal models of depression. Progress in neuro-psychopharmacology & biological psychiatry, 1984, Volume: 8, Issue:3 Topics: Affect; Animals; Antidepressive Agents; Association; Brain; Cognition; Depressive Disorder; Disease	1984
GABA and mood disorders: a brief review and hypothesis. Journal of affective disorders, 1995, Aug-18, Volume: 34, Issue:4 Topics: Biomarkers; Bipolar Disorder; Brain Stem; Depressive Disorder; gamma-Aminobutyric Acid; Hippocampus;	1995
Benzodiazepines as antidepressants: does GABA play a role in depression? Biological psychiatry, 1995, Nov-01, Volume: 38, Issue:9 Topics: Alprazolam; Antidepressive Agents; Benzodiazepines; Chlordiazepoxide; Depressive Disorder; Diazepam;	1995
Serotonin dysfunction disorders: a behavioral neurochemistry perspective. The Journal of clinical psychiatry, 1996, Volume: 57 Suppl 8 Topics: Animals; Antidepressive Agents; Anxiety Disorders; Behavior, Animal; Brain Chemistry; Cognition Diso	1996
The association between premenstrual dysphoric disorder and other mood disorders. The Journal of clinical psychiatry, 1997, Volume: 58 Suppl 15 Topics: Biomarkers; Comorbidity; Depressive Disorder; Diagnosis, Differential; Endorphins; Family; Female; g	1997
Sex, steroids, and sleep: a review. Sleep, 1999, Aug-01, Volume: 22, Issue:5 Topics: Animals; Depressive Disorder; Female; gamma-Aminobutyric Acid; Gonadal Steroid Hormones; Humans; Hyp	1999
Vigabatrin. Epilepsia, 1999, Volume: 40 Suppl 5 Topics: 4-Aminobutyrate Transaminase; Anticonvulsants; Brain Chemistry; Clinical Trials as Topic; Cognition;	1999
Neurobiological mechanisms in generalized anxiety disorder. The Journal of clinical psychiatry, 2001, Volume: 62 Suppl 11 Topics: Anxiety Disorders; Brain; Depressive Disorder; Diagnosis, Differential; gamma-Aminobutyric Acid; Hum	2001
Lamotrigine update and its use in mood disorders. The Annals of pharmacotherapy, 2002, Volume: 36, Issue:5 Topics: Acetates; Aggression; Amines; Antidepressive Agents; Bipolar Disorder; Cyclohexanecarboxylic Acids;	2002
Clinical and biochemical aspects of depressive disorders: II. Transmitter/receptor theories. Synapse (New York, N.Y.), 1991, Volume: 9, Issue:4 Topics: Animals; Depressive Disorder; Dopamine; gamma-Aminobutyric Acid; Humans; Models, Neurological; Neuro	1991
Beyond serotonin. The Journal of clinical psychiatry, 1991, Volume: 52 Suppl Topics: Adenylate Kinase; Antidepressive Agents; Biopterins; Depressive Disorder; gamma-Aminobutyric Acid; H	1991
The gabaergic hypothesis of depression. Progress in neuro-psychopharmacology & biological psychiatry, 1989, Volume: 13, Issue:3-4 Topics: Animals; Behavior; Depressive Disorder; Disease Models, Animal; gamma-Aminobutyric Acid; Humans; Syn	1989
Anxiety and depression: a common neurobiological substrate? The Journal of clinical psychiatry, 1988, Volume: 49 Suppl Topics: Animals; Anxiety Disorders; Arousal; Depressive Disorder; gamma-Aminobutyric Acid; Helplessness, Lea	1988
[Implications of GABAergic synapses in neuropsychiatry]. Journal de pharmacologie, 1985, Volume: 16 Suppl 2 Topics: 4-Aminobutyrate Transaminase; Animals; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents;	1985
Neurochemical aspects of depression: the past and the future? The International journal of neuroscience, 1985, Volume: 27, Issue:1-2 Topics: Antidepressive Agents; Antidepressive Agents, Tricyclic; Brain; Depressive Disorder; Dopamine; Elect	1985
Dosage, seizure threshold, and the antidepressant efficacy of electroconvulsive therapy. Annals of the New York Academy of Sciences, 1986, Volume: 462 Topics: Animals; Cats; Cerebral Cortex; Depressive Disorder; Electroconvulsive Therapy; Endorphins; Epilepsi	1986

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[Effect of acupuncture combined with low frequency rTMS on comorbid mild-to-moderate depressive disorder and insomnia: a randomized controlled trial]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion, 2023, Apr-12, Volume: 43, Issue:4 Topics: Acupuncture Points; Acupuncture Therapy; Brain-Derived Neurotrophic Factor; Depressive Disorder; gam	2023
[New possibilities of pharmacotherapy in cardiovascular patients with mental disorders]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2014, Volume: 114, Issue:9 Topics: Cardiovascular Diseases; Depressive Disorder; Female; gamma-Aminobutyric Acid; Humans; Male; Middle	2014
Tolerability and use in co-administration of pregabalin in affective patients: a 6-month prospective naturalistic study. Expert opinion on drug safety, 2012, Volume: 11, Issue:6 Topics: Adult; Aged; Anticonvulsants; Antidepressive Agents; Anxiety Disorders; Benzodiazepines; Depressive	2012
The potential use of GABA agonists in psychiatric disorders: evidence from studies with progabide in animal models and clinical trials. Pharmacology, biochemistry, and behavior, 1983, Volume: 18, Issue:6 Topics: Adjustment Disorders; Animals; Anticonvulsants; Biogenic Amines; Brain; Clinical Trials as Topic; Co	1983
Baclofen administration for the treatment of affective disorders in alcoholic patients. Drug and alcohol dependence, 1993, Volume: 33, Issue:2 Topics: Administration, Oral; Adult; Alcoholism; Amitriptyline; Anxiety Disorders; Baclofen; Blood Platelets	1993
A beneficial effect on mood in partial epilepsy patients treated with gabapentin. Epilepsia, 1999, Volume: 40, Issue:8 Topics: Acetates; Adult; Affect; Aged; Amines; Anticonvulsants; Anxiety Disorders; Comorbidity; Cyclohexanec	1999
The administration of transcranial electric treatment for affective disturbances therapy in alcoholic patients. Drug and alcohol dependence, 1991, Volume: 27, Issue:1 Topics: Adult; Alcoholism; Alpha Rhythm; Anxiety Disorders; Arousal; Depressive Disorder; Electric Stimulati	1991
GABAmimetics: a new class of antidepressant agents? Archives of general psychiatry, 1990, Volume: 47, Issue:3 Topics: Antidepressive Agents; Depressive Disorder; Female; gamma-Aminobutyric Acid; Humans; Middle Aged	1990
Effects of carbamazepine on cerebrospinal fluid somatostatin. Psychopharmacology, 1985, Volume: 85, Issue:2 Topics: Adrenocorticotropic Hormone; Bipolar Disorder; Carbamazepine; Depressive Disorder; gamma-Aminobutyri	1985

Article	Year
Correlation of Antibodies to Neurotransmitters in the Sera of Women with Alcohol Dependence and Depressive Disorders. Bulletin of experimental biology and medicine, 2021, Volume: 171, Issue:6 Topics: Alcoholism; Autoantibodies; Case-Control Studies; Depressive Disorder; Dopamine; Dysthymic Disorder;	2021
Caspase-1 affects chronic restraint stress-induced depression-like behaviors by modifying GABAergic dysfunction in the hippocampus. Translational psychiatry, 2023, 06-27, Volume: 13, Issue:1 Topics: Animals; Caspase 1; Depression; Depressive Disorder; gamma-Aminobutyric Acid; Hippocampus; Mice; Str	2023
The molecular mechanism underlying GABAergic dysfunction in nucleus accumbens of depression-like behaviours in mice. Journal of cellular and molecular medicine, 2019, Volume: 23, Issue:10 Topics: Animals; Behavior, Animal; Chronic Disease; Depressive Disorder; GABAergic Neurons; gamma-Aminobutyr	2019
Dietary supplementation with Lactobacillus rhamnosus JB-1 restores brain neurochemical balance and mitigates the progression of mood disorder in a rat model of chronic unpredictable mild stress. Nutrition research (New York, N.Y.), 2020, Volume: 82 Topics: Animals; Aspartic Acid; Behavior, Animal; Brain; Choline; Depressive Disorder; Dietary Supplements;	2020
Reciprocal control of obesity and anxiety-depressive disorder via a GABA and serotonin neural circuit. Molecular psychiatry, 2021, Volume: 26, Issue:7 Topics: Agouti-Related Protein; Anxiety; Depression; Depressive Disorder; gamma-Aminobutyric Acid; Humans; O	2021
Early life stress and later peer distress on depressive behavior in adolescent female rats: Effects of a novel intervention on GABA and D2 receptors. Behavioural brain research, 2017, 07-14, Volume: 330 Topics: Animals; Animals, Newborn; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Depression; Depressive Dis	2017
JIEYUANSHEN DECOCTION EXERTS ANTIDEPRESSANT EFFECTS ON DEPRESSIVE RAT MODEL VIA REGULATING HPA AXIS AND THE LEVEL OF AMINO ACIDS NEUROTRANSMITTER. African journal of traditional, complementary, and alternative medicines : AJTCAM, 2017, Volume: 14, Issue:2 Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Chronic Disease; Corticosterone; Cortic	2017
Activity-Dependent Brain-Derived Neurotrophic Factor Release Is Required for the Rapid Antidepressant Actions of Scopolamine. Biological psychiatry, 2018, Jan-01, Volume: 83, Issue:1 Topics: Animals; Antidepressive Agents; Brain; Brain-Derived Neurotrophic Factor; Calcium Channels, L-Type;	2018
Behavioral effects of toll-like receptor-4 antagonist 'eritoran' in an experimental model of depression: role of prefrontal and hippocampal neurogenesis and γ-aminobutyric acid/glutamate balance. Behavioural pharmacology, 2018, Volume: 29, Issue:5 Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Depression; Depressive Disorder;	2018
Minocycline ameliorates anxiety-related self-grooming behaviors and alters hippocampal neuroinflammation, GABA and serum cholesterol levels in female Sprague-Dawley rats subjected to chronic unpredictable mild stress. Behavioural brain research, 2019, 05-02, Volume: 363 Topics: Animals; Anxiety; Anxiety Disorders; Behavior, Animal; Cholesterol; Depression; Depressive Disorder;	2019
Special Issue on Disease: New Advances in Psychiatry. Neuron, 2019, 04-03, Volume: 102, Issue:1 Topics: Animals; Brain; Cerebellum; Depression, Postpartum; Depressive Disorder; Female; gamma-Aminobutyric	2019
Adolescent stress increases depression-like behaviors and alters the excitatory-inhibitory balance in aged mice. Chinese medical journal, 2019, Jul-20, Volume: 132, Issue:14 Topics: Aging; Animals; Anxiety; Brain; Depression; Depressive Disorder; gamma-Aminobutyric Acid; Hippocampu	2019
Dysfunctional glutamatergic and γ-aminobutyric acidergic activities in prefrontal cortex of mice in social defeat model of depression. Biological psychiatry, 2014, Aug-01, Volume: 76, Issue:3 Topics: Animals; Carbon-13 Magnetic Resonance Spectroscopy; Depression; Depressive Disorder; Disease Models,	2014
Pregabalin in acute treatment of anxious depression: a case series. Psychiatry research, 2014, Jan-30, Volume: 215, Issue:1 Topics: Adult; Aged; Anti-Anxiety Agents; Anxiety; Depressive Disorder; Female; gamma-Aminobutyric Acid; Hum	2014
Simultaneous quantification of seven hippocampal neurotransmitters in depression mice by LC-MS/MS. Journal of neuroscience methods, 2014, May-30, Volume: 229 Topics: Animals; Chromatography, Liquid; Depressive Disorder; Disease Models, Animal; Dopamine; gamma-Aminob	2014
Cortical GABA neurons and self-focus in depression: a model linking cellular, biochemical and neural network findings. Molecular psychiatry, 2014, Volume: 19, Issue:9 Topics: Cerebral Cortex; Depressive Disorder; GABAergic Neurons; gamma-Aminobutyric Acid; Humans; Models, Ne	2014
The role of calcitonin gene-related peptide in post-stroke depression in chronic mild stress-treated ischemic rats. Physiology & behavior, 2015, Volume: 139 Topics: Anhedonia; Animals; Antidepressive Agents; Brain Ischemia; Calcitonin Gene-Related Peptide; Chronic	2015
Activation of AMPA Receptors Mediates the Antidepressant Action of Deep Brain Stimulation of the Infralimbic Prefrontal Cortex. Cerebral cortex (New York, N.Y. : 1991), 2016, Volume: 26, Issue:6 Topics: Animals; Deep Brain Stimulation; Depressive Disorder; Disease Models, Animal; Dopamine; gamma-Aminob	2016
Depression and Insulin Resistance: Additional Support for the Novel Heuristic Model in Perimenopausal Depression. The American journal of psychiatry, 2015, Aug-01, Volume: 172, Issue:8 Topics: Depressive Disorder; Female; gamma-Aminobutyric Acid; Gonadal Hormones; Humans; Hypothalamo-Hypophys	2015
Response to Eskola et al. The American journal of psychiatry, 2015, Aug-01, Volume: 172, Issue:8 Topics: Depressive Disorder; Female; gamma-Aminobutyric Acid; Gonadal Hormones; Humans; Hypothalamo-Hypophys	2015
A sensitive and practical RP-HPLC-FLD for determination of the low neuroactive amino acid levels in body fluids and its application in depression. Neuroscience letters, 2016, Mar-11, Volume: 616 Topics: Aged; Aged, 80 and over; Amino Acids; Bipolar Disorder; Body Fluids; Case-Control Studies; Chromatog	2016
Abuse of Gabapentin is Associated with Opioid Addiction. The Psychiatric quarterly, 2016, Volume: 87, Issue:4 Topics: Adult; Amines; Attention Deficit Disorder with Hyperactivity; Comorbidity; Criminals; Cyclohexanecar	2016
[Emotional and personality disorders in atypical facial pain]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2015, Volume: 115, Issue:12 Topics: Adult; Aged; Antidepressive Agents; Anxiety Disorders; Depressive Disorder; Facial Pain; Female; gam	2015
Recovery effect of pre-germinated brown rice on the alteration of sperm quality, testicular structure and androgen receptor expression in rat model of depression. Andrologia, 2017, Volume: 49, Issue:1 Topics: Animals; Antidepressive Agents; Depressive Disorder; Disease Models, Animal; Fluoxetine; gamma-Amino	2017
Design, Synthesis and Evaluation of the Antidepressant and Anticonvulsant Activities of Triazole-Containing Benzo[d]oxazoles. CNS & neurological disorders drug targets, 2017, Volume: 16, Issue:2 Topics: Animals; Anticonvulsants; Antidepressive Agents; Benzoxazoles; Computer Simulation; Depressive Disor	2017
Neuroprotective effect of nebivolol against cisplatin-associated depressive-like behavior in rats. Journal of neurochemistry, 2017, Volume: 141, Issue:3 Topics: Adrenergic beta-Antagonists; Animals; Antineoplastic Agents; Behavior, Animal; Brain Chemistry; Brai	2017
Somatostatin-positive GABAergic interneuron: new targets for depression. Molecular psychiatry, 2017, Volume: 22, Issue:6 Topics: Depression; Depressive Disorder; GABAergic Neurons; gamma-Aminobutyric Acid; Humans; Interneurons; P	2017
Fractalkine/CX3CL1 enhances GABA synaptic activity at serotonin neurons in the rat dorsal raphe nucleus. Neuroscience, 2009, Dec-15, Volume: 164, Issue:3 Topics: Animals; Chemokine CX3CL1; Depressive Disorder; gamma-Aminobutyric Acid; Immune System Diseases; Mal	2009
Calcium binding proteins immunoreactivity in the rat basolateral amygdala following myocardial infarction. Cellular and molecular neurobiology, 2010, Volume: 30, Issue:3 Topics: Amygdala; Animals; Biomarkers; Brain Mapping; Calbindin 2; Calbindins; Calcium-Binding Proteins; Dep	2010
Elevated cortical glutamate in young people at increased familial risk of depression. The international journal of neuropsychopharmacology, 2011, Volume: 14, Issue:2 Topics: Adolescent; Cerebral Cortex; Depression; Depressive Disorder; Depressive Disorder, Major; Family; Fe	2011
Pregabalin in the treatment of posttraumatic stress disorder: a case report. Progress in neuro-psychopharmacology & biological psychiatry, 2011, Jun-01, Volume: 35, Issue:4 Topics: Afghanistan; Anticonvulsants; Antidepressive Agents; Anxiety; Depressive Disorder; gamma-Aminobutyri	2011
Pregabalin augmentation of antidepressants in older patients with comorbid depression and generalized anxiety disorder-an open-label study. International journal of geriatric psychiatry, 2013, Volume: 28, Issue:1 Topics: Aged; Aged, 80 and over; Antidepressive Agents; Anxiety Disorders; Comorbidity; Depressive Disorder;	2013
[Use of pregabalin and sertraline in complex treatment of patients with partial epilepsy comorbid with depressive and anxiety disorders]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2012, Volume: 112, Issue:5 Topics: Adult; Anticonvulsants; Antidepressive Agents; Anxiety Disorders; Depressive Disorder; Drug Therapy,	2012
Norepinephrine-gamma-aminobutyric acid (GABA) interaction in limbic stress circuits: effects of reboxetine on GABAergic neurons. Biological psychiatry, 2003, Jan-15, Volume: 53, Issue:2 Topics: Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Depressive Disorder; Disease	2003
Increased cortical GABA concentrations in depressed patients receiving ECT. The American journal of psychiatry, 2003, Volume: 160, Issue:3 Topics: Anticonvulsants; Antidepressive Agents; Cerebral Cortex; Depressive Disorder; Electroconvulsive Ther	2003
Changes in the level of gamma-aminobutyric acid (GABA) in the ischaemic brain of rats following application of some stimuli evoking spreading EEG depression. Physiologia bohemoslovenica, 1962, Volume: 11 Topics: Amino Acids; Animals; Brain; Brain Chemistry; Depression; Depressive Disorder; Electroencephalograph	1962
Prefrontal cortical projections to the rat dorsal raphe nucleus: ultrastructural features and associations with serotonin and gamma-aminobutyric acid neurons. The Journal of comparative neurology, 2004, Jan-19, Volume: 468, Issue:4 Topics: Animals; Biomarkers; Biotin; Dendrites; Depressive Disorder; Dextrans; gamma-Aminobutyric Acid; Immu	2004
Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression. Archives of general psychiatry, 2004, Volume: 61, Issue:7 Topics: Adult; Aspartic Acid; Choline; Depressive Disorder; Diagnostic and Statistical Manual of Mental Diso	2004
Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression. Archives of general psychiatry, 2004, Volume: 61, Issue:7 Topics: Adult; Aspartic Acid; Choline; Depressive Disorder; Diagnostic and Statistical Manual of Mental Diso	2004
Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression. Archives of general psychiatry, 2004, Volume: 61, Issue:7 Topics: Adult; Aspartic Acid; Choline; Depressive Disorder; Diagnostic and Statistical Manual of Mental Diso	2004
Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression. Archives of general psychiatry, 2004, Volume: 61, Issue:7 Topics: Adult; Aspartic Acid; Choline; Depressive Disorder; Diagnostic and Statistical Manual of Mental Diso	2004
GABAergic hypotheses of anxiety and depression: focus on GABA-B receptors. Drugs of today (Barcelona, Spain : 1998), 2005, Volume: 41, Issue:11 Topics: Allosteric Regulation; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety Disorders; Brain	2005
Cerebrospinal fluid GABA levels in chronic migraine with and without depression. Brain research, 2006, May-23, Volume: 1090, Issue:1 Topics: Brain; Chromatography, High Pressure Liquid; Chronic Disease; Comorbidity; Depressive Disorder; Fema	2006
A preliminary metabolomic analysis of older adults with and without depression. International journal of geriatric psychiatry, 2007, Volume: 22, Issue:5 Topics: Aged; Antidepressive Agents; Biomarkers; Depressive Disorder; Fatty Acids; Female; Follow-Up Studies	2007
Reduced anxiety and depression-like behaviors in mice lacking GABA transporter subtype 1. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2007, Volume: 32, Issue:7 Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety Disorders; Behavior, Animal; Brain; Bra	2007
Augmentation of SSRI effects on serotonin by 5-HT2C antagonists: mechanistic studies. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2007, Volume: 32, Issue:7 Topics: Animals; Brain; Brain Chemistry; Citalopram; Depressive Disorder; Drug Administration Routes; Drug S	2007
Reduction in occipital cortex gamma-aminobutyric acid concentrations in medication-free recovered unipolar depressed and bipolar subjects. Biological psychiatry, 2007, Mar-15, Volume: 61, Issue:6 Topics: Adult; Aged; Analysis of Variance; Aspartic Acid; Bipolar Disorder; Brain Mapping; Depressive Disord	2007
Experimental basis for the antidepressant action of the GABA receptor agonist progabide. Neuroscience letters, 1984, Jun-29, Volume: 47, Issue:3 Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain; Depressive Disorder; gamma-Aminobutyric Aci	1984
Neurochemical basis of the action of antidepressants on learned helplessness. Behavioral and neural biology, 1980, Volume: 30, Issue:2 Topics: Animals; Brain; Depressive Disorder; Desipramine; Frontal Lobe; gamma-Aminobutyric Acid; Geniculate	1980
[Old and new thought concepts on the biochemical principles of psychopharmcotherapy]. Sammlung zwangloser Abhandlungen aus dem Gebiete der Psychiatrie und Neurologie, 1982, Volume: 50 Topics: Acetylcholine; Brain; Depressive Disorder; Dopamine; gamma-Aminobutyric Acid; Humans; Mental Disorde	1982
Neurotransmitter functions in depression. Progress in neuro-psychopharmacology & biological psychiatry, 1982, Volume: 6, Issue:4-6 Topics: Catechol O-Methyltransferase; Depressive Disorder; gamma-Aminobutyric Acid; Homovanillic Acid; Human	1982
CSF neurochemistry of women with anorexia nervosa and normal women. The American journal of psychiatry, 1984, Volume: 141, Issue:11 Topics: Adolescent; Adult; Anorexia Nervosa; Body Weight; Calcium; Choline; Depressive Disorder; Female; gam	1984
CSF neurochemistry in depressed, manic, and schizophrenic patients compared with that of normal controls. The American journal of psychiatry, 1984, Volume: 141, Issue:12 Topics: Adolescent; Adult; Age Factors; Aged; Bipolar Disorder; Calcium; Choline; Depressive Disorder; Femal	1984
Plasma GABA levels in psychiatric illness. Journal of affective disorders, 1984, Volume: 6, Issue:2 Topics: Alcoholism; Bipolar Disorder; Depressive Disorder; Dexamethasone; gamma-Aminobutyric Acid; Humans; L	1984
Receptors and the mechanism of action of ECT. Biological psychiatry, 1982, Volume: 17, Issue:4 Topics: Animals; Brain; Depressive Disorder; Dopamine; Electroconvulsive Therapy; gamma-Aminobutyric Acid; H	1982
Reduced plasma and CSF gamma-aminobutyric acid in affective illness: effect of lithium carbonate. Biological psychiatry, 1983, Volume: 18, Issue:2 Topics: Adult; Bipolar Disorder; Depressive Disorder; Female; gamma-Aminobutyric Acid; Humans; Lithium; Lith	1983
Plasma GABA in affective illness. A preliminary investigation. Journal of affective disorders, 1981, Volume: 3, Issue:4 Topics: Bipolar Disorder; Depressive Disorder; Female; gamma-Aminobutyric Acid; Humans; Male; Schizophrenia	1981
Cerebrospinal fluid gamma-aminobutyric acid and homovanillic acid in depressive disorders. Biological psychiatry, 1982, Volume: 17, Issue:8 Topics: Adult; Age Factors; Bipolar Disorder; Depressive Disorder; Female; gamma-Aminobutyric Acid; Homovani	1982
CSF GABA in normal subjects and patients with depression, schizophrenia, mania, and anorexia nervosa. The American journal of psychiatry, 1981, Volume: 138, Issue:8 Topics: Adolescent; Adult; Affective Disorders, Psychotic; Aged; Anorexia Nervosa; Bipolar Disorder; Depress	1981
Stability of plasma GABA at four-year follow-up in patients with primary unipolar depression. Biological psychiatry, 1995, Jun-01, Volume: 37, Issue:11 Topics: Adult; Aged; Depressive Disorder; Follow-Up Studies; gamma-Aminobutyric Acid; Humans; Male; Middle A	1995
Effects of electroconvulsive therapy on plasma GABA. Convulsive therapy, 1995, Volume: 11, Issue:1 Topics: Adult; Aged; Brain; Depressive Disorder; Electroconvulsive Therapy; Female; gamma-Aminobutyric Acid;	1995
Science reporters hear wide range of recent data at 12th annual conference. JAMA, 1993, Nov-24, Volume: 270, Issue:20 Topics: Acetates; Aged; AIDS Vaccines; American Medical Association; Amines; Animals; Anticonvulsants; beta-	1993
Desipramine does not alter plasma GABA in patients with major depression. Journal of affective disorders, 1993, Volume: 29, Issue:1 Topics: Adult; Aged; Biomarkers; Depressive Disorder; Desipramine; gamma-Aminobutyric Acid; Humans; Male; Mi	1993
Low plasma gamma-aminobutyric acid levels during the late luteal phase of women with premenstrual dysphoric disorder. The American journal of psychiatry, 1996, Volume: 153, Issue:5 Topics: Adult; Depressive Disorder; Female; Follicular Phase; gamma-Aminobutyric Acid; Humans; Luteal Phase;	1996
Growth hormone response to baclofen: a comparison of 10-mg and 20-mg doses in healthy men. Psychiatry research, 1996, Feb-28, Volume: 60, Issue:1 Topics: Adult; Baclofen; Depressive Disorder; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Gro	1996
Gabapentin treatment of mood disorders: a preliminary study. The Journal of clinical psychiatry, 1998, Volume: 59, Issue:8 Topics: Acetates; Adolescent; Adult; Aged; Ambulatory Care; Amines; Anticonvulsants; Antidepressive Agents;	1998
Reduced cortical gamma-aminobutyric acid levels in depressed patients determined by proton magnetic resonance spectroscopy. Archives of general psychiatry, 1999, Volume: 56, Issue:11 Topics: Adult; Age Factors; Cerebral Cortex; Depressive Disorder; Female; gamma-Aminobutyric Acid; Humans; M	1999
Gabapentin leads to remission of somatoform pain disorder with major depression. Pharmacopsychiatry, 1999, Volume: 32, Issue:6 Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Depressive Disorder; Female; Gabapen	1999
Adjunctive gabapentin in treatment-resistant depression: a retrospective chart review. Journal of affective disorders, 2001, Volume: 63, Issue:1-3 Topics: Acetates; Adult; Amines; Anti-Anxiety Agents; Cyclohexanecarboxylic Acids; Depressive Disorder; Dose	2001
Plasma GABA levels correlate with aggressiveness in relatives of patients with unipolar depressive disorder. Psychiatry research, 2001, Mar-25, Volume: 101, Issue:2 Topics: Adult; Age Factors; Aggression; Biomarkers; Case-Control Studies; Depressive Disorder; Family; Femal	2001
Gabapentin treatment of the non-refractory bipolar spectrum: an open case series. Journal of affective disorders, 2001, Volume: 65, Issue:2 Topics: Acetates; Adult; Amines; Antimanic Agents; Bipolar Disorder; Cyclohexanecarboxylic Acids; Depressive	2001
Gabapentin use in geriatric patients with depression and bipolar illness. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2001, Volume: 46, Issue:8 Topics: Acetates; Aged; Aged, 80 and over; Amines; Antidepressive Agents; Bipolar Disorder; Cyclohexanecarbo	2001
Increase in amino acids in the pons after sleep deprivation: a pilot study using proton magnetic resonance spectroscopy. Neuropsychobiology, 2002, Volume: 45, Issue:3 Topics: Adult; Amino Acids; Depressive Disorder; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine;	2002
Gamma-aminobutyric acid-B (GABAB) binding sites in postmortem suicide brains. Neuropsychobiology, 1992, Volume: 26, Issue:1-2 Topics: Adult; Carbon Monoxide Poisoning; Cause of Death; Depressive Disorder; Female; Frontal Lobe; gamma-A	1992
Low plasma gamma-aminobutyric acid levels in male patients with depression. Biological psychiatry, 1992, Aug-15, Volume: 32, Issue:4 Topics: Adult; Cerebral Cortex; Depressive Disorder; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Per	1992
CSF GABA in depressed patients and normal controls. Psychological medicine, 1991, Volume: 21, Issue:3 Topics: Adult; Bipolar Disorder; Depressive Disorder; Female; gamma-Aminobutyric Acid; Homovanillic Acid; Hu	1991
Brain gamma-aminobutyrate transaminase and monoamine oxidase activities in suicide victims. European archives of psychiatry and clinical neuroscience, 1991, Volume: 241, Issue:3 Topics: 4-Aminobutyrate Transaminase; Adolescent; Adult; Age Factors; Aged; Anxiety Disorders; Brain; Brain	1991
Depression among alcoholics. Relationship to clinical and cerebrospinal fluid variables. Archives of general psychiatry, 1991, Volume: 48, Issue:5 Topics: Adult; Age Factors; Alcohol Drinking; Alcoholism; Anxiety Disorders; Depressive Disorder; Divorce; D	1991
The psychopharmacology of GABA synapses: update 1989. Journal of neural transmission. Supplementum, 1990, Volume: 29 Topics: Animals; Antidepressive Agents; Depressive Disorder; gamma-Aminobutyric Acid; Male; Olfactory Bulb;	1990
Chronic antidepressant drug treatment does not affect GH response to baclofen in depressed subjects. Journal of neural transmission. General section, 1990, Volume: 82, Issue:2 Topics: Adult; Amitriptyline; Baclofen; Depressive Disorder; Drug Interactions; gamma-Aminobutyric Acid; Gro	1990
GABA, depression and the mechanism of action of antidepressant drugs: a neuroendocrine approach. Journal of affective disorders, 1990, Volume: 20, Issue:1 Topics: Adult; Amitriptyline; Antidepressive Agents; Baclofen; Brain; Depressive Disorder; Fluoxetine; gamma	1990
Brain amino acid concentrations and Ca2+-dependent release in intractable depression assessed antemortem. Brain research, 1989, Aug-14, Volume: 494, Issue:2 Topics: Aged; Aged, 80 and over; Aspartic Acid; Calcium; Depressive Disorder; Female; Frontal Lobe; gamma-Am	1989
CSF GABA and neuropeptides in pathological gamblers and normal controls. Psychiatry research, 1989, Volume: 30, Issue:2 Topics: Adult; Depressive Disorder; Gambling; gamma-Aminobutyric Acid; Humans; Male; Neuropeptides; Risk-Tak	1989
Brain GABAB binding sites in depressed suicide victims. Psychiatry research, 1988, Volume: 26, Issue:2 Topics: Adolescent; Adult; Aged; Antidepressive Agents; Brain; Depressive Disorder; Female; Frontal Lobe; ga	1988
The GABA hypothesis of depression and antidepressant drug action. Psychopharmacology bulletin, 1985, Volume: 21, Issue:3 Topics: Animals; Antidepressive Agents; Biogenic Amines; Depressive Disorder; gamma-Aminobutyric Acid; Human	1985
Diazepam-binding inhibitor. A brain neuropeptide present in human spinal fluid: studies in depression, schizophrenia, and Alzheimer's disease. Archives of general psychiatry, 1986, Volume: 43, Issue:12 Topics: Adult; Age Factors; Aged; Alzheimer Disease; Depressive Disorder; Diazepam Binding Inhibitor; Female	1986
GABA synapses, depression, and antidepressant drugs. Psychopharmacology series, 1987, Volume: 3 Topics: Antidepressive Agents; Brain; Depressive Disorder; gamma-Aminobutyric Acid; Humans; Synaptic Transmi	1987
Fengabine, a novel antidepressant GABAergic agent. I. Activity in models for antidepressant drugs and psychopharmacological profile. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:1 Topics: Animals; Antidepressive Agents; Avoidance Learning; Behavior, Animal; Bicuculline; Chlorophenols; Cl	1987
[2 new GABA-ergics (GABA-linoleamide and GABA-steatamide). On 2 experimental models of depression]. Agressologie: revue internationale de physio-biologie et de pharmacologie appliquees aux effets de l'agression, 1985, Volume: 26, Issue:7 Topics: Animals; Apomorphine; Catalepsy; Depressive Disorder; Drug Synergism; gamma-Aminobutyric Acid; Human	1985

gamma-aminobutyric acid and Depressive Disorder