gamma-aminobutyric acid has been researched along with Depressive Disorder, Major in 133 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
Depressive Disorder, Major: Disorder in which five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. Symptoms include: depressed mood most of the day, nearly every daily; markedly diminished interest or pleasure in activities most of the day, nearly every day; significant weight loss when not dieting or weight gain; Insomnia or hypersomnia nearly every day; psychomotor agitation or retardation nearly every day; fatigue or loss of energy nearly every day; feelings of worthlessness or excessive or inappropriate guilt; diminished ability to think or concentrate, or indecisiveness, nearly every day; or recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt. (DSM-5)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Low gamma-aminobutyric acid (GABA) is implicated in both anxiety and depression pathophysiology." | 7.80 | Anxiety in major depression and cerebrospinal fluid free gamma-aminobutyric acid. ( Boldrini, M; Cooper, TB; Currier, D; Ellis, SP; Malone, KM; Mann, JJ; Oquendo, MA; Sullivan, G; Watson, KT; Xie, S, 2014) |
| "To assess the effectiveness and safety of adjunctive pregabalin to antidepressants for residual anxiety in patients with major depressive disorder (MDD)." | 7.79 | Adjunctive pregabalin in partial responders with major depressive disorder and residual anxiety. ( Aceti, F; Ceccanti, M; Fava, M; Fehling, K; Mistretta, M; Tedeschini, E; Vitali, M, 2013) |
| "The results suggest a possible augmentation role for pregabalin when used in conjunction with conventional antidepressants for residual anxiety in MDD." | 7.79 | Adjunctive pregabalin in partial responders with major depressive disorder and residual anxiety. ( Aceti, F; Ceccanti, M; Fava, M; Fehling, K; Mistretta, M; Tedeschini, E; Vitali, M, 2013) |
| " Here, we examined whether levels of immunological protein markers changed with depression, age, or the inhibitory neurotransmitter gamma-aminobutyric acid (GABA)." | 3.91 | Depression, GABA, and Age Correlate with Plasma Levels of Inflammatory Markers. ( Bhandage, AK; Birnir, B; Bongiovanni, S; Cunningham, JL; Ekselius, L; Jin, Z; Kamali-Moghaddam, M; Korol, SV; Shen, Q; Syk, M, 2019) |
| "There is growing evidence for GABA and glutamate-glutamine dysfunction in the pathogenesis of mood and anxiety disorders." | 3.91 | Association between prefrontal glutamine levels and neuroticism determined using proton magnetic resonance spectroscopy. ( Brechbühl, S; Buchmann, A; Ghisleni, C; Hasler, G; Haynes, M; Müller, ST; Tuura, R, 2019) |
| "Low gamma-aminobutyric acid (GABA) is implicated in both anxiety and depression pathophysiology." | 3.80 | Anxiety in major depression and cerebrospinal fluid free gamma-aminobutyric acid. ( Boldrini, M; Cooper, TB; Currier, D; Ellis, SP; Malone, KM; Mann, JJ; Oquendo, MA; Sullivan, G; Watson, KT; Xie, S, 2014) |
| "To assess the effectiveness and safety of adjunctive pregabalin to antidepressants for residual anxiety in patients with major depressive disorder (MDD)." | 3.79 | Adjunctive pregabalin in partial responders with major depressive disorder and residual anxiety. ( Aceti, F; Ceccanti, M; Fava, M; Fehling, K; Mistretta, M; Tedeschini, E; Vitali, M, 2013) |
| "The results suggest a possible augmentation role for pregabalin when used in conjunction with conventional antidepressants for residual anxiety in MDD." | 3.79 | Adjunctive pregabalin in partial responders with major depressive disorder and residual anxiety. ( Aceti, F; Ceccanti, M; Fava, M; Fehling, K; Mistretta, M; Tedeschini, E; Vitali, M, 2013) |
| "We determined the gene expression of 32 markers of the pathways of the two main neurotransmitters of the PFC, gamma-aminobutyric acid (GABA) and l-glutamic acid (glutamate), by real-time quantitative PCR in human postmortem anterior cingulate cortex (ACC) and dorsolateral PFC (DLPFC) in elderly non-suicidal patients with major depressive disorder (MDD) or bipolar disorder (BD)." | 3.78 | Gene expression of GABA and glutamate pathway markers in the prefrontal cortex of non-suicidal elderly depressed patients. ( Bao, AM; Kamphuis, W; Lou, JS; Luchetti, S; Qi, XR; Swaab, DF; Zhao, J, 2012) |
| "The pathophysiology of major depressive disorder (MDD) is thought to result from impaired connectivity between key brain networks." | 3.01 | Understanding the mechanism of action and clinical effects of neuroactive steroids and GABAergic compounds in major depressive disorder. ( Cutler, AJ; Maletic, V; Mattingly, GW, 2023) |
| "The pathophysiology of major depressive disorder (MDD), one of the major causes of worldwide disability, is still largely unclear, despite the increasing data reporting evidence of multiple alterations of different systems." | 2.82 | GABA System in Depression: Impact on Pathophysiology and Psychopharmacology. ( Arone, A; Della Vecchia, A; Marazziti, D; Mucci, F; Piccinni, A, 2022) |
| "Individuals with major depressive disorder (MDD) often use hypnotics like zolpidem (Ambien(®)) to improve sleep in addition to their selective serotonin reuptake inhibitor (SSRI) regimen." | 2.79 | Zolpidem increases GABA in depressed volunteers maintained on SSRIs. ( Conn, NA; Jensen, JE; Licata, SC; Lukas, SE; Winer, JP, 2014) |
| "Aside from treating insomnia, using zolpidem in the presence of SSRIs may have some unidentified therapeutic effects for depressed individuals." | 2.79 | Zolpidem increases GABA in depressed volunteers maintained on SSRIs. ( Conn, NA; Jensen, JE; Licata, SC; Lukas, SE; Winer, JP, 2014) |
| "MDD and PTSD patients present abnormalities in the HPA axis regulation, such as altered cortisol levels or failure to suppress cortisol release in the dexamethasone suppression test." | 2.72 | The Role of HPA Axis and Allopregnanolone on the Neurobiology of Major Depressive Disorders and PTSD. ( Almeida, FB; Barros, HMT; Pinna, G, 2021) |
| "Gamma-aminobutyric acid (GABA) plays a key role in the pathophysiology and treatment of depression and anxiety." | 2.72 | Open-label tiagabine monotherapy for major depressive disorder with anxiety. ( Carpenter, LL; Haggarty, R; Mello, AF; Mello, MF; Price, LH; Schecter, JM; Tyrka, AR, 2006) |
| "Mood disorders and Major Depressive Disorder, in particular, appear to be some of the most common psychiatric disorders with a high rate of comorbidity most frequently of anxiety or substance abuse disorders (alcohol use disorder)." | 2.66 | Immunological Disturbances and Neuroimaging Findings in Major Depressive Disorder (MDD) and Alcohol Use Disorder (AUD) Comorbid Patients. ( Kakanakova, A; Maes, M; Popov, S, 2020) |
| "In patients with major depressive disorder or bipolar disorder, abnormalities in excitatory and/or inhibitory neurotransmission and neuronal plasticity may lead to aberrant functional connectivity patterns within large brain networks." | 2.55 | Glutamate and Gamma-Aminobutyric Acid Systems in the Pathophysiology of Major Depression and Antidepressant Response to Ketamine. ( Ballard, ED; Lener, MS; Niciu, MJ; Nugent, AC; Park, LT; Park, M; Zarate, CA, 2017) |
| "Discovering biomarkers of major depressive disorder (MDD) can give a deeper understanding of this mood disorder and improve the ability to screen for, diagnose, and treat MDD." | 1.72 | Metabolomic profiling relates tianeptine effectiveness with hippocampal GABA, myo-inositol, cholesterol, and fatty acid metabolism restoration in socially isolated rats. ( Beškoski, V; Filipović, D; Lješević, M; Nikolić, M; Perić, I, 2022) |
| "Both Major Depressive Disorder (MDD) and Primary Insomnia (PI) have been linked to deficiencies in cortical γ-aminobutyric acid (GABA) and glutamate (Glu) thus suggesting a shared neurobiological link between these two conditions." | 1.56 | ( Baer, L; Benson, KL; Bottary, R; Eric Jensen, J; Gonenc, A; Schoerning, L; Winkelman, JW, 2020) |
| "The extent to which comorbid insomnia contributes to GABAergic or glutamatergic deficiencies in MDD remains unclear." | 1.56 | ( Baer, L; Benson, KL; Bottary, R; Eric Jensen, J; Gonenc, A; Schoerning, L; Winkelman, JW, 2020) |
| "Major depressive disorder is increasingly recognized to involve functional deficits in both gamma-aminobutyric acid (GABA)ergic and glutamatergic synaptic transmission." | 1.43 | Bidirectional Homeostatic Regulation of a Depression-Related Brain State by Gamma-Aminobutyric Acidergic Deficits and Ketamine Treatment. ( Fuchs, T; Jefferson, SJ; Luscher, B; Pribiag, H; Ren, Z; Shorey, M; Stellwagen, D, 2016) |
| "The GABAergic deficit hypothesis of major depressive disorders (MDDs) posits that reduced γ-aminobutyric acid (GABA) concentration in brain, impaired function of GABAergic interneurons, altered expression and function of GABA(A) receptors, and changes in GABAergic transmission dictated by altered chloride homeostasis can contribute to the etiology of MDD." | 1.42 | GABAergic control of depression-related brain states. ( Fuchs, T; Luscher, B, 2015) |
| "Thirty-three medication-free major depressive disorder (MDD; 14 TRD and 19 non-TRD) and 26 healthy controls (HC) subjects were studied." | 1.42 | Prefrontal cortical GABA abnormalities are associated with reduced hippocampal volume in major depressive disorder. ( Abdallah, CG; Cheema, R; Coplan, JD; Jackowski, A; Kang, G; Mao, X; Mathew, SJ; Sato, JR; Shungu, DC, 2015) |
| "Research on novel treatments for major depressive disorder focuses quite deeply on glutamate function, and this research would benefit from a brain-imaging technique that precisely quantified glutamate function." | 1.40 | Glutamate metabolism in major depressive disorder. ( Abdallah, CG; De Feyter, HM; Fasula, M; Jiang, L; Krystal, JH; Mason, GF; Rothman, DL; Sanacora, G, 2014) |
| "Twenty-four participants with major depressive disorder and 22 healthy controls matched for age and sex." | 1.39 | Evidence for increased glutamatergic cortical facilitation in children and adolescents with major depressive disorder. ( Buyukdura, JS; Croarkin, PE; Daskalakis, ZJ; Emslie, GJ; Husain, MM; Kennard, BD; Kozel, FA; Melton, T; Nakonezny, PA, 2013) |
| "These findings suggest that major depressive disorder in children and adolescents is associated with increased intracortical facilitation and excessive glutamatergic activity." | 1.39 | Evidence for increased glutamatergic cortical facilitation in children and adolescents with major depressive disorder. ( Buyukdura, JS; Croarkin, PE; Daskalakis, ZJ; Emslie, GJ; Husain, MM; Kennard, BD; Kozel, FA; Melton, T; Nakonezny, PA, 2013) |
| "Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter." | 1.39 | Reduced GAD(65/67) immunoreactivity in the hypothalamic paraventricular nucleus in depression: a postmortem study. ( Bao, AM; Gao, SF; Klomp, A; Swaab, DF; Wu, JL, 2013) |
| "Anhedonia, a core symptom of major depressive disorder (MDD) and highly variable among adolescents with MDD, may involve alterations in the major inhibitory amino acid neurotransmitter system of γ-aminobutyric acid (GABA)." | 1.38 | Anterior cingulate cortex γ-aminobutyric acid in depressed adolescents: relationship to anhedonia. ( Alonso, CM; Babb, JS; Ely, BA; Gabbay, V; Klein, RG; Mao, X; Panzer, AM; Shungu, DC, 2012) |
| "Insomnia is closely related to major depressive disorder (MDD) both cross-sectionally and longitudinally, and as such, offers potential opportunities to refine our understanding of the neurobiology of both sleep and mood disorders." | 1.38 | Reduced γ-aminobutyric acid in occipital and anterior cingulate cortices in primary insomnia: a link to major depressive disorder? ( Jensen, JE; Plante, DT; Schoerning, L; Winkelman, JW, 2012) |
| "Ten subjects with major depressive disorder (MDD) received saline, then ketamine in a fixed order, one week apart, under single-blind conditions." | 1.37 | The antidepressant effect of ketamine is not associated with changes in occipital amino acid neurotransmitter content as measured by [(1)H]-MRS. ( Fasula, M; Gomez, R; Krystal, JH; Mason, GF; Pittman, B; Sanacora, G; Valentine, GW; Watzl, J, 2011) |
| "Gabapentin is an antiepileptic drug that is prescribed for both FDA-approved and multiple off-label conditions, and has a relatively safe side-effect profile." | 1.37 | Suicide by gabapentin overdose. ( Middleton, O, 2011) |
| "A 24-year-old woman with major depressive disorder (MDD) with reduced psychomotor activity was identified with unusually high serum GAD65 and Ro52 autoantibody titers." | 1.36 | High levels of Anti-GAD65 and Anti-Ro52 autoantibodies in a patient with major depressive disorder showing psychomotor disturbance. ( Burbelo, PD; Carlson, PJ; Ching, KH; Drevets, WC; Iadarola, MJ, 2010) |
| "Tobacco smoking and depression are strongly associated, but the possible effects of SHS have not been evaluated." | 1.36 | Secondhand smoke exposure and depressive symptoms. ( Arheart, KL; Bandiera, FC; Caban-Martinez, AJ; Davila, EP; Dietz, NA; Fleming, LE; Leblanc, WG; Lee, DJ; Lewis, JE; McCollister, K; Serdar, B, 2010) |
| "Increasing evidence indicates that major depressive disorder (MDD) is associated with altered function of the major excitatory and inhibitory neurotransmitters glutamate and gamma-aminobutyric acid (GABA), respectively." | 1.34 | Reduced prefrontal glutamate/glutamine and gamma-aminobutyric acid levels in major depression determined using proton magnetic resonance spectroscopy. ( Drevets, WC; Hasler, G; Meyers, N; Shen, J; Tumonis, T; van der Veen, JW, 2007) |
| "Major depressive disorder has been associated with neuroimaging and neuropathological abnormalities in the prefrontal cortex by various types of evidence." | 1.33 | Normal prefrontal gamma-aminobutyric acid levels in remitted depressed subjects determined by proton magnetic resonance spectroscopy. ( Bain, EE; Charney, DS; Drevets, WC; Hasler, G; Neumeister, A; Shen, J; Tumonis, T; van der Veen, JW, 2005) |
| "Gamma-aminobutyric acid levels were measured in the ventromedial prefrontal cortex and dorsolateral/anterior medial prefrontal cortex." | 1.33 | Normal prefrontal gamma-aminobutyric acid levels in remitted depressed subjects determined by proton magnetic resonance spectroscopy. ( Bain, EE; Charney, DS; Drevets, WC; Hasler, G; Neumeister, A; Shen, J; Tumonis, T; van der Veen, JW, 2005) |
| "Patients were assessed for PTSD and major depressive disorder at 6-week and 1-year follow-ups." | 1.33 | Relationship between posttrauma GABA plasma levels and PTSD at 1-year follow-up. ( Boss, V; Brunet, A; Devos, P; Ducrocq, F; Fontaine, M; Goudemand, M; Laffargue, P; Thomas, P; Vaiva, G, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 30 (22.56) | 29.6817 |
| 2010's | 66 (49.62) | 24.3611 |
| 2020's | 37 (27.82) | 2.80 |
| Authors | Studies |
|---|---|
| Gunduz-Bruce, H | 1 |
| Takahashi, K | 1 |
| Huang, MY | 1 |
| Liu, DY | 2 |
| Ju, X | 2 |
| Gao, Y | 2 |
| Han, JF | 1 |
| Li, Z | 2 |
| Hu, XW | 2 |
| Tan, ZL | 3 |
| Northoff, G | 6 |
| Song, XM | 2 |
| Della Vecchia, A | 1 |
| Arone, A | 1 |
| Piccinni, A | 1 |
| Mucci, F | 1 |
| Marazziti, D | 1 |
| Ngoupaye, GT | 1 |
| Mokgokong, M | 1 |
| Madlala, T | 1 |
| Mabandla, MV | 1 |
| Wang, L | 1 |
| Yang, P | 1 |
| Yang, C | 1 |
| Yang, D | 1 |
| Wu, X | 1 |
| Cao, T | 1 |
| Zeng, C | 1 |
| Chen, Q | 1 |
| Zhang, S | 1 |
| Zhu, Z | 1 |
| Jiao, S | 1 |
| Cai, H | 1 |
| Gonsalves, MA | 1 |
| White, TL | 1 |
| Barredo, J | 1 |
| Fukuda, AM | 1 |
| Joyce, HE | 1 |
| Harris, AD | 1 |
| Carpenter, LL | 2 |
| Perić, I | 1 |
| Lješević, M | 1 |
| Beškoski, V | 1 |
| Nikolić, M | 1 |
| Filipović, D | 1 |
| Biermann, L | 1 |
| Wunram, HL | 1 |
| Pokorny, L | 1 |
| Breitinger, E | 1 |
| Großheinrich, N | 1 |
| Jarczok, TA | 1 |
| Bender, S | 1 |
| Hong, J | 1 |
| Vernon, D | 1 |
| Kunovac, J | 1 |
| Stahl, S | 2 |
| Tran, KH | 1 |
| Luki, J | 1 |
| Hanstock, S | 1 |
| Hanstock, CC | 1 |
| Seres, P | 1 |
| Aitchison, K | 1 |
| Shandro, T | 1 |
| Le Melledo, JM | 1 |
| Jagadeesh, KA | 1 |
| Dey, KK | 1 |
| Montoro, DT | 1 |
| Mohan, R | 1 |
| Gazal, S | 1 |
| Engreitz, JM | 1 |
| Xavier, RJ | 1 |
| Price, AL | 1 |
| Regev, A | 1 |
| Ritter, C | 1 |
| Buchmann, A | 2 |
| Müller, ST | 2 |
| Volleberg, M | 1 |
| Haynes, M | 2 |
| Ghisleni, C | 2 |
| Noeske, R | 1 |
| Tuura, R | 2 |
| Hasler, G | 6 |
| Lu, K | 1 |
| Hong, Y | 1 |
| Tao, M | 1 |
| Shen, L | 1 |
| Zheng, Z | 1 |
| Fang, K | 1 |
| Yuan, F | 1 |
| Xu, M | 1 |
| Wang, C | 1 |
| Zhu, D | 1 |
| Guo, X | 1 |
| Liu, Y | 1 |
| Rupprecht, R | 2 |
| Pradhan, AK | 1 |
| Kufner, M | 1 |
| Brunner, LM | 1 |
| Nothdurfter, C | 1 |
| Wein, S | 1 |
| Schwarzbach, J | 1 |
| Puig, X | 1 |
| Rupprecht, C | 1 |
| Rammes, G | 1 |
| Ali, M | 1 |
| Ullah, I | 1 |
| Diwan, MN | 1 |
| Aamir, A | 1 |
| Awan, HA | 1 |
| Waris Durrani, A | 1 |
| Qudrat, QU | 1 |
| Shoib, S | 1 |
| De Berardis, D | 1 |
| Deligiannidis, KM | 1 |
| Clayton, AH | 1 |
| Cooper, T | 1 |
| Seigler, MD | 1 |
| Tri, BD | 1 |
| Shashni, B | 1 |
| Matsui, H | 1 |
| Nagasaki, Y | 1 |
| Bailey, AM | 1 |
| Barrett, A | 1 |
| Havens, L | 1 |
| Leyder, E | 1 |
| Merchant, T | 1 |
| Starnes, H | 1 |
| Thompson, SM | 1 |
| Cutler, AJ | 1 |
| Mattingly, GW | 1 |
| Maletic, V | 1 |
| Hu, YT | 1 |
| Hirjak, D | 1 |
| Luscher, B | 5 |
| Maguire, JL | 1 |
| Rudolph, U | 1 |
| Sibille, E | 3 |
| Uchida, T | 1 |
| Sugiura, Y | 1 |
| Sugiyama, E | 1 |
| Maeda, R | 1 |
| Tanaka, KF | 1 |
| Suematsu, M | 1 |
| Mimura, M | 1 |
| Uchida, H | 1 |
| Patterson, R | 1 |
| Balan, I | 1 |
| Morrow, AL | 1 |
| Meltzer-Brody, S | 1 |
| Bhandage, AK | 1 |
| Cunningham, JL | 1 |
| Jin, Z | 1 |
| Shen, Q | 2 |
| Bongiovanni, S | 1 |
| Korol, SV | 1 |
| Syk, M | 1 |
| Kamali-Moghaddam, M | 1 |
| Ekselius, L | 1 |
| Birnir, B | 1 |
| Streeter, CC | 1 |
| Gerbarg, PL | 1 |
| Brown, RP | 1 |
| Scott, TM | 1 |
| Nielsen, GH | 1 |
| Owen, L | 1 |
| Sakai, O | 1 |
| Sneider, JT | 1 |
| Nyer, MB | 1 |
| Silveri, MM | 1 |
| Draganov, M | 1 |
| Vives-Gilabert, Y | 1 |
| de Diego-Adeliño, J | 1 |
| Vicent-Gil, M | 1 |
| Puigdemont, D | 1 |
| Portella, MJ | 1 |
| Kokane, SS | 1 |
| Armant, RJ | 1 |
| Bolaños-Guzmán, CA | 1 |
| Perrotti, LI | 1 |
| Kakanakova, A | 1 |
| Popov, S | 1 |
| Maes, M | 1 |
| Benson, KL | 1 |
| Bottary, R | 1 |
| Schoerning, L | 2 |
| Baer, L | 1 |
| Gonenc, A | 1 |
| Eric Jensen, J | 1 |
| Winkelman, JW | 2 |
| Czéh, B | 1 |
| Simon, M | 1 |
| Milak, MS | 2 |
| Rashid, R | 1 |
| Dong, Z | 1 |
| Kegeles, LS | 2 |
| Grunebaum, MF | 1 |
| Ogden, RT | 2 |
| Lin, X | 1 |
| Mulhern, ST | 2 |
| Suckow, RF | 2 |
| Cooper, TB | 3 |
| Keilp, JG | 2 |
| Mao, X | 8 |
| Shungu, DC | 8 |
| Mann, JJ | 5 |
| Seymour, J | 1 |
| Fogaça, MV | 1 |
| Wu, M | 1 |
| Li, C | 1 |
| Li, XY | 1 |
| Picciotto, MR | 1 |
| Duman, RS | 1 |
| Truong, V | 1 |
| Cheng, PZ | 1 |
| Lee, HC | 1 |
| Lane, TJ | 1 |
| Hsu, TY | 1 |
| Duncan, NW | 1 |
| Wang, QN | 1 |
| Xue, C | 1 |
| Cai, YC | 1 |
| Bai, R | 1 |
| Almeida, FB | 1 |
| Pinna, G | 1 |
| Barros, HMT | 1 |
| Ironside, M | 1 |
| Moser, AD | 1 |
| Holsen, LM | 1 |
| Zuo, CS | 1 |
| Du, F | 1 |
| Perlo, S | 1 |
| Richards, CE | 1 |
| Duda, JM | 1 |
| Chen, X | 1 |
| Nickerson, LD | 1 |
| Null, KE | 1 |
| Nascimento, N | 1 |
| Crowley, DJ | 1 |
| Misra, M | 1 |
| Goldstein, JM | 1 |
| Pizzagalli, DA | 1 |
| Gabbay, V | 3 |
| Bradley, KA | 2 |
| Ostrover, R | 1 |
| Kang, G | 3 |
| Romeo, B | 1 |
| Choucha, W | 1 |
| Fossati, P | 1 |
| Rotge, JY | 1 |
| Balzekas, I | 1 |
| Lewis, CP | 1 |
| Shekunov, J | 1 |
| Port, JD | 1 |
| Worrell, GA | 1 |
| Joon Jo, H | 1 |
| Croarkin, PE | 3 |
| Alonso, CM | 2 |
| Mehra, LM | 1 |
| Xu, J | 1 |
| Pech, J | 1 |
| Forman, J | 1 |
| Kessing, LV | 1 |
| Knorr, U | 1 |
| Knudsen, MK | 1 |
| Near, J | 4 |
| Blicher, AB | 1 |
| Videbech, P | 1 |
| Blicher, JU | 1 |
| Godfrey, KEM | 1 |
| Gardner, AC | 1 |
| Kwon, S | 1 |
| Chea, W | 1 |
| Muthukumaraswamy, SD | 1 |
| Flores-Ramos, M | 1 |
| Alcauter, S | 1 |
| López-Titla, M | 1 |
| Bernal-Santamaría, N | 1 |
| Calva-Coraza, E | 1 |
| Edden, RAE | 1 |
| Strandwitz, P | 1 |
| Kim, KH | 1 |
| Terekhova, D | 1 |
| Liu, JK | 1 |
| Sharma, A | 1 |
| Levering, J | 1 |
| McDonald, D | 1 |
| Dietrich, D | 1 |
| Ramadhar, TR | 1 |
| Lekbua, A | 1 |
| Mroue, N | 1 |
| Liston, C | 2 |
| Stewart, EJ | 1 |
| Dubin, MJ | 2 |
| Zengler, K | 1 |
| Knight, R | 1 |
| Gilbert, JA | 1 |
| Clardy, J | 1 |
| Lewis, K | 1 |
| Hui, J | 1 |
| Tremblay, S | 1 |
| Daskalakis, ZJ | 4 |
| Levitt, JG | 1 |
| Kalender, G | 1 |
| O’Neill, J | 1 |
| Diaz, JP | 1 |
| Cook, IA | 1 |
| Ginder, N | 1 |
| Krantz, D | 1 |
| Minzenberg, MJ | 1 |
| Vince-Cruz, N | 1 |
| Nguyen, LD | 1 |
| Alger, JR | 1 |
| Leuchter, AF | 1 |
| Brechbühl, S | 1 |
| Preuss, N | 1 |
| Salehi, B | 1 |
| van der Veen, JW | 4 |
| Shen, J | 4 |
| Drevets, WC | 5 |
| Hodgkinson, C | 1 |
| Goldman, D | 1 |
| Vigod, SN | 1 |
| Strasburg, K | 1 |
| Blumberger, DM | 1 |
| Ren, L | 1 |
| Qian, X | 1 |
| Zhai, L | 1 |
| Sun, M | 1 |
| Miao, Z | 1 |
| Li, J | 1 |
| Xu, X | 1 |
| Lu, YR | 1 |
| Fu, XY | 1 |
| Shi, LG | 1 |
| Jiang, Y | 1 |
| Wu, JL | 2 |
| Weng, XJ | 1 |
| Wang, ZP | 1 |
| Wu, XY | 1 |
| Lin, Z | 1 |
| Liu, WB | 1 |
| Li, HC | 1 |
| Luo, JH | 1 |
| Bao, AM | 3 |
| Oquendo, MA | 3 |
| Watson, KT | 1 |
| Boldrini, M | 1 |
| Malone, KM | 1 |
| Ellis, SP | 1 |
| Sullivan, G | 1 |
| Xie, S | 1 |
| Currier, D | 1 |
| Abdallah, CG | 2 |
| Jiang, L | 1 |
| De Feyter, HM | 1 |
| Fasula, M | 2 |
| Krystal, JH | 4 |
| Rothman, DL | 3 |
| Mason, GF | 5 |
| Sanacora, G | 6 |
| Godlewska, BR | 1 |
| Cowen, PJ | 2 |
| Licata, SC | 1 |
| Jensen, JE | 2 |
| Conn, NA | 1 |
| Winer, JP | 1 |
| Lukas, SE | 1 |
| Ren, Z | 2 |
| Sahir, N | 2 |
| Murakami, S | 1 |
| Luellen, BA | 1 |
| Earnheart, JC | 1 |
| Lal, R | 1 |
| Kim, JY | 1 |
| Song, H | 1 |
| Kalia, M | 1 |
| Costa E Silva, J | 1 |
| Fuchs, T | 2 |
| Pehrson, AL | 1 |
| Sanchez, C | 1 |
| Jackowski, A | 1 |
| Sato, JR | 1 |
| Cheema, R | 1 |
| Coplan, JD | 1 |
| Mathew, SJ | 3 |
| Kimoto, S | 1 |
| Zaki, MM | 1 |
| Bazmi, HH | 1 |
| Lewis, DA | 2 |
| Mowla, A | 1 |
| Ahmadzadeh, L | 1 |
| Razeghian Jahromi, L | 1 |
| Dastgheib, SA | 1 |
| Proper, CJ | 1 |
| Parter, AL | 1 |
| Rodriguez, CI | 1 |
| Bonnet, U | 1 |
| Ossowski, A | 1 |
| Schubert, M | 1 |
| Gall, H | 1 |
| Steinkamp, I | 1 |
| Richter, LE | 1 |
| Khalil-Boutros, Y | 1 |
| Nefedev, A | 1 |
| Kuhlmann, R | 1 |
| Jha, MK | 1 |
| Sachdeva, S | 1 |
| Yin, H | 1 |
| Pantazatos, SP | 2 |
| Galfalvy, H | 1 |
| Huang, YY | 2 |
| Rosoklija, GB | 2 |
| Dwork, AJ | 2 |
| Burke, A | 1 |
| Arango, V | 2 |
| Banerjee, S | 1 |
| Goodman, Z | 1 |
| Lapidus, KA | 1 |
| Pribiag, H | 1 |
| Jefferson, SJ | 1 |
| Shorey, M | 1 |
| Stellwagen, D | 1 |
| Zhang, X | 3 |
| Tang, Y | 1 |
| Maletic-Savatic, M | 1 |
| Sheng, J | 1 |
| Zhu, Y | 1 |
| Zhang, T | 1 |
| Wang, J | 2 |
| Tong, S | 1 |
| Li, Y | 1 |
| Jollant, F | 1 |
| Richard-Devantoy, S | 1 |
| Ding, Y | 1 |
| Turecki, G | 4 |
| Bechara, A | 1 |
| Rosa, PB | 1 |
| Neis, VB | 1 |
| Ribeiro, CM | 1 |
| Moretti, M | 1 |
| Rodrigues, AL | 1 |
| Lener, MS | 1 |
| Niciu, MJ | 1 |
| Ballard, ED | 1 |
| Park, M | 1 |
| Park, LT | 1 |
| Nugent, AC | 1 |
| Zarate, CA | 2 |
| Schür, RR | 1 |
| Boks, MP | 1 |
| Geuze, E | 1 |
| Prinsen, HC | 1 |
| Verhoeven-Duif, NM | 1 |
| Joëls, M | 1 |
| Kahn, RS | 1 |
| Vermetten, E | 1 |
| Vinkers, CH | 1 |
| Ma, K | 1 |
| Xu, A | 1 |
| Cui, S | 1 |
| Sun, MR | 1 |
| Xue, YC | 1 |
| Wang, JH | 1 |
| Mechawar, N | 2 |
| Savitz, J | 1 |
| Murck, H | 1 |
| Schubert, MI | 1 |
| Schmid, D | 1 |
| Schüssler, P | 1 |
| Steiger, A | 1 |
| Auer, DP | 1 |
| Esel, E | 1 |
| Kose, K | 1 |
| Hacimusalar, Y | 1 |
| Ozsoy, S | 1 |
| Kula, M | 1 |
| Candan, Z | 1 |
| Turan, T | 1 |
| Block, W | 1 |
| Träber, F | 1 |
| von Widdern, O | 1 |
| Metten, M | 1 |
| Schild, H | 1 |
| Maier, W | 1 |
| Zobel, A | 1 |
| Jessen, F | 1 |
| Price, RB | 1 |
| Nestadt, P | 2 |
| Kelly, C | 2 |
| Collins, KA | 2 |
| Murrough, JW | 2 |
| Charney, DS | 3 |
| Roman, M | 1 |
| Walter, M | 1 |
| Henning, A | 1 |
| Grimm, S | 1 |
| Schulte, RF | 1 |
| Beck, J | 1 |
| Dydak, U | 1 |
| Schnepf, B | 1 |
| Boeker, H | 1 |
| Boesiger, P | 1 |
| Pae, CU | 1 |
| Sequeira, A | 3 |
| Mamdani, F | 1 |
| Ernst, C | 2 |
| Vawter, MP | 2 |
| Bunney, WE | 2 |
| Lebel, V | 1 |
| Rehal, S | 1 |
| Klempan, T | 2 |
| Gratton, A | 1 |
| Benkelfat, C | 2 |
| Rouleau, GA | 2 |
| Klumpers, UM | 1 |
| Veltman, DJ | 1 |
| Drent, ML | 1 |
| Boellaard, R | 1 |
| Comans, EF | 1 |
| Meynen, G | 1 |
| Lammertsma, AA | 1 |
| Hoogendijk, WJ | 1 |
| Bandiera, FC | 1 |
| Arheart, KL | 1 |
| Caban-Martinez, AJ | 1 |
| Fleming, LE | 1 |
| McCollister, K | 1 |
| Dietz, NA | 1 |
| Leblanc, WG | 1 |
| Davila, EP | 1 |
| Lewis, JE | 1 |
| Serdar, B | 1 |
| Lee, DJ | 1 |
| Ching, KH | 1 |
| Burbelo, PD | 1 |
| Carlson, PJ | 1 |
| Iadarola, MJ | 1 |
| Andrade, G | 1 |
| Levine, SM | 1 |
| Taylor, MJ | 1 |
| Mannie, ZN | 1 |
| Norbury, R | 1 |
| Levinson, AJ | 1 |
| Valentine, GW | 1 |
| Gomez, R | 1 |
| Watzl, J | 1 |
| Pittman, B | 1 |
| Middleton, O | 1 |
| Klein, RG | 1 |
| Ely, BA | 1 |
| Babb, JS | 1 |
| Panzer, AM | 1 |
| Salvadore, G | 1 |
| Zhang, Y | 1 |
| Marenco, S | 1 |
| Machado-Vieira, R | 1 |
| Baumann, J | 1 |
| Ibrahim, LA | 1 |
| Luckenbaugh, DA | 1 |
| Puts, NA | 1 |
| Edden, RA | 1 |
| Plante, DT | 1 |
| Zhao, J | 1 |
| Qi, XR | 1 |
| Kamphuis, W | 1 |
| Luchetti, S | 1 |
| Lou, JS | 1 |
| Swaab, DF | 2 |
| Song, Z | 1 |
| Huang, P | 1 |
| Qiu, L | 1 |
| Wu, Q | 1 |
| Gong, Q | 1 |
| Zhang, B | 1 |
| Heberlein, K | 1 |
| Xie, P | 1 |
| Sommer, C | 1 |
| Häuser, W | 1 |
| Alten, R | 1 |
| Petzke, F | 1 |
| Späth, M | 1 |
| Tölle, T | 1 |
| Uçeyler, N | 1 |
| Winkelmann, A | 1 |
| Winter, E | 1 |
| Bär, KJ | 1 |
| Tripp, A | 1 |
| Oh, H | 1 |
| Guilloux, JP | 1 |
| Martinowich, K | 1 |
| Vitali, M | 1 |
| Tedeschini, E | 1 |
| Mistretta, M | 1 |
| Fehling, K | 1 |
| Aceti, F | 1 |
| Ceccanti, M | 1 |
| Fava, M | 1 |
| Nakonezny, PA | 1 |
| Husain, MM | 1 |
| Melton, T | 1 |
| Buyukdura, JS | 1 |
| Kennard, BD | 1 |
| Emslie, GJ | 1 |
| Kozel, FA | 1 |
| Gao, SF | 1 |
| Klomp, A | 1 |
| Pu, M | 1 |
| Zhang, Z | 1 |
| Xu, Z | 1 |
| Shi, Y | 1 |
| Geng, L | 1 |
| Yuan, Y | 1 |
| Reynolds, GP | 1 |
| Romeo, E | 1 |
| Pompili, E | 1 |
| di Michele, F | 1 |
| Pace, M | 1 |
| Bernardi, G | 1 |
| Pasinib, A | 1 |
| Malek-Ahmadi, P | 1 |
| Kugaya, A | 1 |
| Verhoeff, NP | 1 |
| Fujita, M | 1 |
| Seneca, NM | 1 |
| Bozkurt, A | 1 |
| Khan, SA | 1 |
| Anand, A | 1 |
| Degen, K | 1 |
| Zoghbi, SS | 1 |
| Baldwin, RM | 1 |
| Seibyl, JP | 1 |
| Innis, RB | 1 |
| Neumeister, A | 1 |
| Tumonis, T | 2 |
| Bain, EE | 1 |
| Fenton, LR | 1 |
| Fasula, MK | 1 |
| Levin, Y | 1 |
| Bajbouj, M | 2 |
| Lisanby, SH | 1 |
| Lang, UE | 2 |
| Danker-Hopfe, H | 1 |
| Heuser, I | 2 |
| Neu, P | 2 |
| Choudary, PV | 1 |
| Molnar, M | 1 |
| Evans, SJ | 1 |
| Tomita, H | 1 |
| Li, JZ | 1 |
| Myers, RM | 1 |
| Akil, H | 1 |
| Watson, SJ | 1 |
| Jones, EG | 1 |
| Palmio, J | 1 |
| Huuhka, M | 1 |
| Saransaari, P | 1 |
| Oja, SS | 1 |
| Peltola, J | 1 |
| Leinonen, E | 1 |
| Suhonen, J | 1 |
| Keränen, T | 1 |
| Schecter, JM | 1 |
| Tyrka, AR | 1 |
| Mello, AF | 1 |
| Mello, MF | 1 |
| Haggarty, R | 1 |
| Price, LH | 1 |
| Saxena, K | 1 |
| Howe, M | 1 |
| Simeonova, D | 1 |
| Steiner, H | 1 |
| Chang, K | 1 |
| Yildiz-Yesiloglu, A | 1 |
| Ankerst, DP | 1 |
| Lanctôt, KL | 1 |
| Herrmann, N | 1 |
| Rothenburg, L | 1 |
| Eryavec, G | 1 |
| Vaiva, G | 1 |
| Boss, V | 1 |
| Ducrocq, F | 1 |
| Fontaine, M | 1 |
| Devos, P | 1 |
| Brunet, A | 1 |
| Laffargue, P | 1 |
| Goudemand, M | 1 |
| Thomas, P | 1 |
| Rajkowska, G | 1 |
| O'Dwyer, G | 1 |
| Teleki, Z | 1 |
| Stockmeier, CA | 1 |
| Miguel-Hidalgo, JJ | 1 |
| Meyers, N | 1 |
| Canetti, L | 2 |
| ffrench-Mullen, J | 2 |
| Bhagwagar, Z | 1 |
| Wylezinska, M | 1 |
| Jezzard, P | 1 |
| Evans, J | 1 |
| Boorman, E | 1 |
| M Matthews, P | 1 |
| J Cowen, P | 1 |
| Klempan, TA | 1 |
| Lalovic, A | 1 |
| Mervaala, E | 1 |
| Könönen, M | 1 |
| Föhr, J | 1 |
| Husso-Saastamoinen, M | 1 |
| Valkonen-Korhonen, M | 1 |
| Kuikka, JT | 1 |
| Viinamäki, H | 1 |
| Tammi, AK | 1 |
| Tiihonen, J | 1 |
| Partanen, J | 1 |
| Lehtonen, J | 1 |
| Cotter, D | 1 |
| Landau, S | 1 |
| Beasley, C | 1 |
| Stevenson, R | 1 |
| Chana, G | 1 |
| MacMillan, L | 1 |
| Everall, I | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Validation of the Glx Biomarker for Treatment of Moderate Bipolar Depression With NRX-101[NCT03402152] | Phase 2/Phase 3 | 8 participants (Actual) | Interventional | 2018-11-01 | Completed | ||
| The Antidepressant Action of Ketamine: Brain Chemistry[NCT01558063] | Phase 2 | 38 participants (Actual) | Interventional | 2012-02-29 | Completed | ||
| Repurposing of Dextromethorphan as an Adjunct Therapy in Patients With Major Depressive Disorder: A Randomized, Group Sequential, Adaptive Design, Controlled Clinical Trial[NCT05181527] | Phase 4 | 60 participants (Actual) | Interventional | 2022-02-10 | Completed | ||
| The Protective Role of Preoperative Stimulation of the Distal Limb of the Ileostomy Loop With GABA Before Ileostomy Closure[NCT05905393] | Phase 3 | 80 participants (Anticipated) | Interventional | 2023-06-30 | Not yet recruiting | ||
| Role of the Gut Microbiome as Determinant of Depression in Multiple Sclerosis Subjects[NCT05808101] | 120 participants (Anticipated) | Observational | 2022-01-27 | Recruiting | |||
| A Phase I Randomized, Double-blinded, Placebo-controlled Dose Escalation Study to Evaluate the Safety, Tolerability, and Pharmacokinetic of HS-10353 in Chinese Adult Subjects[NCT05195203] | Phase 1 | 96 participants (Actual) | Interventional | 2021-01-27 | Completed | ||
| Integrins and Protocadherins in Glutamatergic Circuits: Identification of Common Signaling Pathways and Molecular Targets in Anxiety and Major Depressive Disorders (GAPsy)[NCT06167590] | 20 participants (Anticipated) | Interventional | 2022-07-15 | Recruiting | |||
| Evaluation of Schemes of Administration of Intravenous Ketamine in Treatment-resistant Depression: Clinical-neuroimaging Correlation[NCT03742557] | Phase 3 | 30 participants (Anticipated) | Interventional | 2018-10-01 | Recruiting | ||
| Evaluation of the Antidepressant Effects of Nitrous Oxide in People With Major Depressive Disorder[NCT05357040] | Phase 2 | 172 participants (Anticipated) | Interventional | 2021-06-30 | Recruiting | ||
| An Innovative Smartphone-enabled Health Coaching Intervention for Youth Diagnosed With Major Depressive Disorders[NCT03406052] | 168 participants (Anticipated) | Interventional | 2018-01-19 | Suspended (stopped due to New funding required) | |||
| Clinical Trial of the Use of Ketamine in Treatment Resistant Depression[NCT02610712] | Phase 4 | 20 participants (Anticipated) | Interventional | 2014-05-31 | Recruiting | ||
| The Neurophysiological Effects of Intravenous Alcohol as Potential Biomarkers of Ketamine's Rapid Antidepressant Effects in Major Depressive Disorder[NCT02122562] | Phase 2 | 60 participants (Anticipated) | Interventional | 2014-04-23 | Recruiting | ||
| Imaging Framework for Testing GABAergic/Glutamatergic Drugs in Bipolar Alcoholics[NCT03220776] | Phase 2 | 54 participants (Actual) | Interventional | 2017-08-07 | Completed | ||
| Glutamatergic and GABAergic Biomarkers in rTMS for Adolescent Depression[NCT03363919] | 70 participants (Actual) | Interventional | 2018-09-24 | Completed | |||
| Effects of Single-dose L-theanine on Motor Cortex Excitability in Healthy Subjects: A Double-blinded, Randomized Order, Cross-over Paired-Pulse Transcranial Magnetic Stimulation Study[NCT04749745] | Early Phase 1 | 11 participants (Actual) | Interventional | 2020-06-09 | Completed | ||
| Cerebral Neuroinflammation During Major Depressive Episode: Multicentric Comparative Study.[NCT03314155] | 60 participants (Anticipated) | Interventional | 2018-12-07 | Recruiting | |||
| Treating Refractory Major Depressive Disorder With Repetitive Transcranial Magnetic Stimulation: A Double-blind, Sham-controlled, Longitudinal Study.[NCT00305045] | 73 participants (Actual) | Interventional | 2005-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The quantitative depressive symptom ratings were collected at Baseline, Day 1 (post ketamine), Day 3 using HDRS-24 (a 24-item questionnaire used to provide an indication of depression, and as a guide to evaluate recovery). The total score can range from 0 to a maximum score of 15 with a higher score indicating a worse outcome. A responder was defined as an individual exhibiting a reduction in the HDRS score from baseline to 24 hours (day 1) post-treatment, and all other individuals were classified as non-responders." (NCT01558063)
Timeframe: Day 1 (post ketamine)
| Intervention | participants (Number) |
|---|---|
| Ketamine Dose 1 | 3 |
| Ketamine Dose 2 | 1 |
| Ketamine Dose 3 | 3 |
| Ketamine Dose 4 | 2 |
| Ketamine Dose 5 | 2 |
| Saline Solution | 0 |
Concentrations of GABA+, referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy (i.e., MEGA-PRESS). (NCT03220776)
Timeframe: Day 5 of each experimental condition
| Intervention | mmol/kg (Mean) |
|---|---|
| N-Acetylcysteine | 3.90 |
| Gabapentin | 3.93 |
| Placebo Oral Tablet | 3.73 |
Concentrations of Glx (i.e., glutamate + glutamine), referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy. (NCT03220776)
Timeframe: Day 5 of each experimental condition
| Intervention | mmol/kg (Mean) |
|---|---|
| N-Acetylcysteine | 21.59 |
| Gabapentin | 21.69 |
| Placebo Oral Tablet | 22.25 |
"The changes of Short-interval Intracortical Inhibition (SICI), Intracortical Facilitation (ICF), and Long-interval Intracortical Inhibition (LICI) before and 30 minutes after each drug administration.~SICI, ICF and LICI are paired-pulse TMS (ppTMS)-EMG outcome measures that assess the activity of motor cortex GABA-A, NMDA and GABA-B interneurons, respectively. They are measured by the ratio between the peak-to-peak amplitude of motor-evoked potential (MEP) elicited by a testing TMS pulse (120% of the intensity of the resting motor threshold, following a conditioning pulse at different inter-stimuli interval, 2-5 milliseconds for SICI, 10-20 milliseconds for ICF, 100-200 milliseconds for LICI) and the peak-to-peak MEP amplitude elicited by a single pulse (120% of the intensity of the resting motor threshold).~The baseline-to-post-drug change of SICI, ICF and LICI elicited by L-theanine will be compared to that elicited by placebo within each subject." (NCT04749745)
Timeframe: Before and 30 minutes after each drug administration (no long-term follow up as this is a study on acute effect of a single-dose agent).
| Intervention | Ratio (Mean) | ||
|---|---|---|---|
| SICI | ICF | LICI | |
| L-Theanine | 0.059 | 0.073 | 0.145 |
| Placebo | 0.005 | -0.341 | -0.068 |
30 reviews available for gamma-aminobutyric acid and Depressive Disorder, Major
| Article | Year |
|---|---|
Development of neuroactive steroids for the treatment of postpartum depression.
Topics: Child; Depression, Postpartum; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Humans; | 2022 |
GABA System in Depression: Impact on Pathophysiology and Psychopharmacology.
Topics: Antidepressive Agents; Depression; Depressive Disorder, Major; gamma-Aminobutyric Acid; Humans; Neur | 2022 |
Repetitive Transcranial Magnetic Stimulation-Associated Changes in Neocortical Metabolites in Major Depression: A Systematic Review.
Topics: Depression; Depressive Disorder, Major; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; N | 2022 |
Emerging drugs for the treatment of major depressive disorder.
Topics: Antidepressive Agents; Antipsychotic Agents; Depressive Disorder, Major; gamma-Aminobutyric Acid; Hu | 2022 |
Neurosteroids and translocator protein 18 kDa (TSPO) in depression: implications for synaptic plasticity, cognition, and treatment options.
Topics: Anti-Anxiety Agents; Benzodiazepines; Carrier Proteins; Cognition; Depression; Depression, Postpartu | 2023 |
Zuranolone and its role in treating major depressive disorder: a narrative review.
Topics: Depressive Disorder, Major; Double-Blind Method; gamma-Aminobutyric Acid; Humans; Pregnanes; Prospec | 2023 |
Understanding the mechanism of action and clinical effects of neuroactive steroids and GABAergic compounds in major depressive disorder.
Topics: Adult; Antidepressive Agents; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Humans; N | 2023 |
Brain-wide changes in excitation-inhibition balance of major depressive disorder: a systematic review of topographic patterns of GABA- and glutamatergic alterations.
Topics: Brain; Depressive Disorder, Major; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Magnetic Resonanc | 2023 |
GABA
Topics: Antidepressive Agents; Cognition; Depression; Depressive Disorder, Major; gamma-Aminobutyric Acid; H | 2023 |
Novel neurosteroid therapeutics for post-partum depression: perspectives on clinical trials, program development, active research, and future directions.
Topics: Depression, Postpartum; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Humans; Neurost | 2024 |
Overlap in the neural circuitry and molecular mechanisms underlying ketamine abuse and its use as an antidepressant.
Topics: Antidepressive Agents; Brain; Cholinergic Neurons; Depressive Disorder, Major; Depressive Disorder, | 2020 |
Immunological Disturbances and Neuroimaging Findings in Major Depressive Disorder (MDD) and Alcohol Use Disorder (AUD) Comorbid Patients.
Topics: Alcoholism; Anxiety Disorders; Brain; Comorbidity; Cytokines; Depressive Disorder, Major; gamma-Amin | 2020 |
Benefits of animal models to understand the pathophysiology of depressive disorders.
Topics: Animals; Antidepressive Agents; Biomarkers; Depressive Disorder, Major; Disease Models, Animal; gamm | 2021 |
Occipital gamma-aminobutyric acid and glutamate-glutamine alterations in major depressive disorder: An mrs study and meta-analysis.
Topics: Depressive Disorder, Major; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Magnetic Reso | 2021 |
The Role of HPA Axis and Allopregnanolone on the Neurobiology of Major Depressive Disorders and PTSD.
Topics: Adaptation, Physiological; Animals; Antidepressive Agents; Chronic Disease; Corticosterone; Depressi | 2021 |
Meta-analysis of central and peripheral γ-aminobutyric acid levels in patients with unipolar and bipolar depression.
Topics: Adolescent; Adult; Aged; Biomarkers; Bipolar Disorder; Brain; Depressive Disorder, Major; Female; ga | 2018 |
Poor evidence for putative abnormalities in cerebrospinal fluid neurotransmitters in patients with depression versus healthy non-psychiatric individuals: A systematic review and meta-analyses of 23 studies.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Depressive Disorder, Major; Female; gamma-Aminobutyric A | 2018 |
Differences in excitatory and inhibitory neurotransmitter levels between depressed patients and healthy controls: A systematic review and meta-analysis.
Topics: Depressive Disorder, Major; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans | 2018 |
The Current and Future Potential of Transcranial Magnetic Stimulation With Electroencephalography in Psychiatry.
Topics: Biomarkers; Bipolar Disorder; Depressive Disorder, Major; Electroencephalography; Frontal Lobe; gamm | 2019 |
Systematic review of gamma-aminobutyric-acid inhibitory deficits across the reproductive life cycle.
Topics: Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Humans; Menopause; Menstrual Cycle; Neu | 2014 |
Biomarkers of psychiatric diseases: current status and future prospects.
Topics: Acetyltransferases; Alzheimer Disease; Biomarkers; Bipolar Disorder; Brain; Brain-Derived Neurotroph | 2015 |
Altered γ-aminobutyric acid neurotransmission in major depressive disorder: a critical review of the supporting evidence and the influence of serotonergic antidepressants.
Topics: Animals; Antidepressive Agents; Brain; Depressive Disorder, Major; Evidence-Based Medicine; Fluoxeti | 2015 |
Glutamate and Gamma-Aminobutyric Acid Systems in the Pathophysiology of Major Depression and Antidepressant Response to Ketamine.
Topics: Animals; Antidepressive Agents; Depressive Disorder, Major; gamma-Aminobutyric Acid; Glutamic Acid; | 2017 |
Glutamate and Gamma-Aminobutyric Acid Systems in the Pathophysiology of Major Depression and Antidepressant Response to Ketamine.
Topics: Animals; Antidepressive Agents; Depressive Disorder, Major; gamma-Aminobutyric Acid; Glutamic Acid; | 2017 |
Glutamate and Gamma-Aminobutyric Acid Systems in the Pathophysiology of Major Depression and Antidepressant Response to Ketamine.
Topics: Animals; Antidepressive Agents; Depressive Disorder, Major; gamma-Aminobutyric Acid; Glutamic Acid; | 2017 |
Glutamate and Gamma-Aminobutyric Acid Systems in the Pathophysiology of Major Depression and Antidepressant Response to Ketamine.
Topics: Animals; Antidepressive Agents; Depressive Disorder, Major; gamma-Aminobutyric Acid; Glutamic Acid; | 2017 |
Neuropathology of mood disorders: do we see the stigmata of inflammation?
Topics: Astrocytes; Autoimmune Diseases of the Nervous System; Bipolar Disorder; Brain; Depressive Disorder, | 2016 |
Cortical inhibition, gamma-aminobutyric acid, and major depression: there is plenty of smoke but is there fire?
Topics: Cerebral Cortex; Depressive Disorder, Major; gamma-Aminobutyric Acid; Humans; Neural Inhibition; Rec | 2010 |
Evidence for GABAergic inhibitory deficits in major depressive disorder.
Topics: Animals; Cerebral Cortex; Depressive Disorder, Major; Diagnostic Imaging; gamma-Aminobutyric Acid; H | 2011 |
Discovering imaging endophenotypes for major depression.
Topics: Depressive Disorder, Major; Diagnostic Imaging; Endophenotypes; gamma-Aminobutyric Acid; Humans; Mod | 2011 |
In vivo magnetic resonance spectroscopy of GABA: a methodological review.
Topics: Bipolar Disorder; Depressive Disorder, Major; Epilepsy; gamma-Aminobutyric Acid; Humans; Magnetic Re | 2012 |
[Drug therapy of fibromyalgia syndrome. Systematic review, meta-analysis and guideline].
Topics: Amitriptyline; Analgesics; Analgesics, Opioid; Antidepressive Agents; Anxiety Disorders; Combined Mo | 2012 |
Review of 1H magnetic resonance spectroscopy findings in major depressive disorder: a meta-analysis.
Topics: Aspartic Acid; Brain; Choline; Creatine; Depressive Disorder, Major; gamma-Aminobutyric Acid; Glutam | 2006 |
10 trials available for gamma-aminobutyric acid and Depressive Disorder, Major
| Article | Year |
|---|---|
Thalamic Gamma Aminobutyric Acid Level Changes in Major Depressive Disorder After a 12-Week Iyengar Yoga and Coherent Breathing Intervention.
Topics: Adult; Anxiety; Breathing Exercises; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Hu | 2020 |
Assessment of Relationship of Ketamine Dose With Magnetic Resonance Spectroscopy of Glx and GABA Responses in Adults With Major Depression: A Randomized Clinical Trial.
Topics: Adult; Antidepressive Agents; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Glutamic | 2020 |
Assessment of Relationship of Ketamine Dose With Magnetic Resonance Spectroscopy of Glx and GABA Responses in Adults With Major Depression: A Randomized Clinical Trial.
Topics: Adult; Antidepressive Agents; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Glutamic | 2020 |
Assessment of Relationship of Ketamine Dose With Magnetic Resonance Spectroscopy of Glx and GABA Responses in Adults With Major Depression: A Randomized Clinical Trial.
Topics: Adult; Antidepressive Agents; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Glutamic | 2020 |
Assessment of Relationship of Ketamine Dose With Magnetic Resonance Spectroscopy of Glx and GABA Responses in Adults With Major Depression: A Randomized Clinical Trial.
Topics: Adult; Antidepressive Agents; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Glutamic | 2020 |
Zolpidem increases GABA in depressed volunteers maintained on SSRIs.
Topics: Adult; Depressive Disorder, Major; Female; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Humans | 2014 |
Comparing Gabapentin with Clonazepam for Residual Sleeping Problems following Antidepressant Therapy in Patients with Major Depressive Disorder: A Randomized Clinical Trial.
Topics: Adult; Amines; Antidepressive Agents; Clonazepam; Cyclohexanecarboxylic Acids; Depressive Disorder, | 2015 |
The glutamatergic system and its relation to the clinical effect of therapeutic-sleep deprivation in depression - an MR spectroscopy study.
Topics: Adult; Aged; Analysis of Variance; Antidepressive Agents; Choline; Creatine; Depressive Disorder, Ma | 2009 |
Reduced parahippocampal and lateral temporal GABAA-[11C]flumazenil binding in major depression: preliminary results.
Topics: Adult; Antidepressive Agents; Carbon Radioisotopes; Case-Control Studies; Corticotropin-Releasing Ho | 2010 |
Effects of fluoxetine, indomethacine and placebo on 3 alpha, 5 alpha tetrahydroprogesterone (THP) plasma levels in uncomplicated alcohol withdrawal.
Topics: Adult; Depressive Disorder, Major; Diagnostic and Statistical Manual of Mental Disorders; Ethanol; F | 2000 |
Therapeutic brain stimulation and cortical excitability in depressed patients.
Topics: Adult; Aged; Brain; Cerebral Cortex; Depressive Disorder, Major; Electric Stimulation Therapy; Elect | 2005 |
Open-label tiagabine monotherapy for major depressive disorder with anxiety.
Topics: Adult; Ambulatory Care; Anxiety Disorders; Comorbidity; Depressive Disorder, Major; Drug Administrat | 2006 |
Divalproex sodium reduces overall aggression in youth at high risk for bipolar disorder.
Topics: Adolescent; Affect; Aggression; Antimanic Agents; Attention Deficit and Disruptive Behavior Disorder | 2006 |
93 other studies available for gamma-aminobutyric acid and Depressive Disorder, Major
| Article | Year |
|---|---|
From Molecular to Behavior: Higher Order Occipital Cortex in Major Depressive Disorder.
Topics: Depressive Disorder, Major; gamma-Aminobutyric Acid; Humans; Magnetic Resonance Imaging; Occipital L | 2022 |
Alteration of the α5 GABA receptor and 5HTT lead to cognitive deficits associated with major depressive-like behaviors in a 14-day combined stress rat model.
Topics: Acetylcholinesterase; Animals; Cognition; Corticosterone; Depression; Depressive Disorder, Major; Di | 2023 |
Disturbance of neurotransmitter metabolism in drug-naïve, first-episode major depressive disorder: a comparative study on adult and adolescent cohorts.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adolescent; Adult; Biomarkers; Depressive Disorder, Major; Dopamine; | 2022 |
Metabolomic profiling relates tianeptine effectiveness with hippocampal GABA, myo-inositol, cholesterol, and fatty acid metabolism restoration in socially isolated rats.
Topics: Animals; Cholesterol; Depressive Disorder, Major; Fatty Acids; gamma-Aminobutyric Acid; Hippocampus; | 2022 |
Changes in the TMS-evoked potential N100 in the dorsolateral prefrontal cortex as a function of depression severity in adolescents.
Topics: Adolescent; Depression; Depressive Disorder, Major; Dorsolateral Prefrontal Cortex; Electroencephalo | 2022 |
Decreased GABA+ Levels in the Medial Prefrontal Cortex of Perimenopausal Women: A 3T 1H-MRS Study.
Topics: Adult; Creatine; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Humans; Magnetic Reson | 2023 |
Identifying disease-critical cell types and cellular processes by integrating single-cell RNA-sequencing and human genetics.
Topics: Depressive Disorder, Major; gamma-Aminobutyric Acid; Genetic Predisposition to Disease; Genome-Wide | 2022 |
Evaluation of Prefrontal γ-Aminobutyric Acid and Glutamate Levels in Individuals With Major Depressive Disorder Using Proton Magnetic Resonance Spectroscopy.
Topics: Adult; Cross-Sectional Studies; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Glutami | 2022 |
Depressive patient-derived GABA interneurons reveal abnormal neural activity associated with HTR2C.
Topics: Cell Differentiation; Depressive Disorder, Major; gamma-Aminobutyric Acid; Humans; Interneurons; Neu | 2023 |
Patient-Specific Considerations, the GABA Pathway, and New Clinical Trial Data on Neuroactive Steroids in MDD and PPD.
Topics: Antidepressive Agents; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Female; | 2023 |
Rapid onset brain plasticity at novel pharmacologic targets hypothetically drives innovations for rapid onset antidepressant actions.
Topics: Antidepressive Agents; Depressive Disorder, Major; gamma-Aminobutyric Acid; Hallucinogens; Humans; N | 2023 |
Designing poly(gamma-aminobutyric acid)-based nanoparticles for the treatment of major depressive disorders.
Topics: Animals; Blood-Brain Barrier; Brain; Depressive Disorder, Major; gamma-Aminobutyric Acid; Mice; Qual | 2023 |
Changes in social, sexual, and hedonic behaviors in rats in response to stress and restoration by a negative allosteric modulator of α5-subunit containing GABA receptor.
Topics: Animals; Antidepressive Agents; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Humans; | 2023 |
Metabolites for monitoring symptoms and predicting remission in patients with depression who received electroconvulsive therapy: a pilot study.
Topics: Biomarkers; Depression; Depressive Disorder, Major; Electroconvulsive Therapy; gamma-Aminobutyric Ac | 2023 |
Depression, GABA, and Age Correlate with Plasma Levels of Inflammatory Markers.
Topics: Adult; Age Factors; Aged; Biomarkers; Depression; Depressive Disorder, Major; Female; gamma-Aminobut | 2019 |
Glutamatergic and GABA-ergic abnormalities in First-episode depression. A 1-year follow-up 1H-MR spectroscopic study.
Topics: Depression; Depressive Disorder, Major; Follow-Up Studies; gamma-Aminobutyric Acid; Glutamic Acid; G | 2020 |
Topics: Adult; Depression; Depressive Disorder, Major; gamma-Aminobutyric Acid; Glutamic Acid; Gyrus Cinguli | 2020 |
Commentary and Update on the Contribution of the GABA Hypothesis to Understanding the Mechanism of Action of Electroconvulsive Therapy.
Topics: Animals; Brain; Brain Chemistry; Depressive Disorder, Major; Electroconvulsive Therapy; gamma-Aminob | 2021 |
Inhibition of GABA interneurons in the mPFC is sufficient and necessary for rapid antidepressant responses.
Topics: Animals; Antidepressive Agents; Depressive Disorder, Major; gamma-Aminobutyric Acid; Interneurons; M | 2021 |
Reduction of higher-order occipital GABA and impaired visual perception in acute major depressive disorder.
Topics: Depression; Depressive Disorder, Major; gamma-Aminobutyric Acid; Humans; Occipital Lobe; Proton Magn | 2021 |
Reductions in rostral anterior cingulate GABA are associated with stress circuitry in females with major depression: a multimodal imaging investigation.
Topics: Adult; Brain Mapping; Depression; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Gyrus | 2021 |
Anterior cingulate cortex γ-aminobutyric acid deficits in youth with depression.
Topics: Adolescent; Anhedonia; Brain; Child; Depression; Depressive Disorder, Major; Female; gamma-Aminobuty | 2017 |
A pilot study of GABA
Topics: Adolescent; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Humans; Magnetic Resonance | 2018 |
Elevated striatal γ-aminobutyric acid in youth with major depressive disorder.
Topics: Adolescent; Child; Corpus Striatum; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Gyr | 2018 |
Magnetic resonance (MR) spectroscopic measurement of γ-aminobutyric acid (GABA) in major depression before and after electroconvulsive therapy.
Topics: Adult; Aspartic Acid; Depressive Disorder, Major; Electroconvulsive Therapy; Female; gamma-Aminobuty | 2019 |
Testosterone is related to GABA+ levels in the posterior-cingulate in unmedicated depressed women during reproductive life.
Topics: Adult; Antidepressive Agents; Cross-Sectional Studies; Depressive Disorder, Major; Female; Follicula | 2019 |
GABA-modulating bacteria of the human gut microbiota.
Topics: Adult; Aged; Bacteria; Bacteroides; Brain; Cohort Studies; Depression; Depressive Disorder, Major; F | 2019 |
GABA-modulating bacteria of the human gut microbiota.
Topics: Adult; Aged; Bacteria; Bacteroides; Brain; Cohort Studies; Depression; Depressive Disorder, Major; F | 2019 |
GABA-modulating bacteria of the human gut microbiota.
Topics: Adult; Aged; Bacteria; Bacteroides; Brain; Cohort Studies; Depression; Depressive Disorder, Major; F | 2019 |
GABA-modulating bacteria of the human gut microbiota.
Topics: Adult; Aged; Bacteria; Bacteroides; Brain; Cohort Studies; Depression; Depressive Disorder, Major; F | 2019 |
Dorsolateral prefrontal γ-aminobutyric acid in patients with treatment-resistant depression after transcranial magnetic stimulation measured with magnetic resonance spectroscopy
Topics: Adult; Antidepressive Agents; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; | 2019 |
Association between prefrontal glutamine levels and neuroticism determined using proton magnetic resonance spectroscopy.
Topics: Adult; Anxiety Disorders; Cross-Sectional Studies; Depressive Disorder, Major; Female; gamma-Aminobu | 2019 |
Associations between prefrontal γ-aminobutyric acid concentration and the tryptophan hydroxylase isoform 2 gene, a panic disorder risk allele in women.
Topics: Adult; Alleles; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Genetic Association Stu | 2013 |
Loss of Ahi1 impairs neurotransmitter release and causes depressive behaviors in mice.
Topics: Adaptor Proteins, Vesicular Transport; Animals; Behavior, Animal; Depressive Disorder, Major; Dopami | 2014 |
Decreased plasma neuroactive amino acids and increased nitric oxide levels in melancholic major depressive disorder.
Topics: Adult; Aged; Amino Acids; Antidepressive Agents; Aspartic Acid; Biomarkers; Depressive Disorder, Maj | 2014 |
Anxiety in major depression and cerebrospinal fluid free gamma-aminobutyric acid.
Topics: Adult; Age Factors; Anxiety; Bipolar Disorder; Case-Control Studies; Chromatography, High Pressure L | 2014 |
Why are cortical GABA neurons relevant to internal focus in depression? A cross-level model linking cellular, biochemical and neural network findings.
Topics: Cerebral Cortex; Depressive Disorder, Major; GABAergic Neurons; gamma-Aminobutyric Acid; Humans; Mod | 2014 |
Glutamate metabolism in major depressive disorder.
Topics: Adult; Aged; Carbon Isotopes; Citric Acid Cycle; Depressive Disorder, Major; Female; gamma-Aminobuty | 2014 |
Neurochemistry of major depression: a study using magnetic resonance spectroscopy.
Topics: Adult; Citalopram; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Glutamic Acid; Gluta | 2015 |
Defects in dendrite and spine maturation and synaptogenesis associated with an anxious-depressive-like phenotype of GABAA receptor-deficient mice.
Topics: Animals; Anxiety; Brain-Derived Neurotrophic Factor; Cells, Cultured; Cerebral Cortex; Dendrites; De | 2015 |
GABAergic control of depression-related brain states.
Topics: Animals; Antidepressive Agents; Brain; Depressive Disorder, Major; Disease Models, Animal; gamma-Ami | 2015 |
Prefrontal cortical GABA abnormalities are associated with reduced hippocampal volume in major depressive disorder.
Topics: Adult; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Gyrus Cinguli; Hippocampus; Huma | 2015 |
Altered Markers of Cortical γ-Aminobutyric Acid Neuronal Activity in Schizophrenia: Role of the NARP Gene.
Topics: Biomarkers; Bipolar Disorder; C-Reactive Protein; Case-Control Studies; Cytoskeletal Proteins; Depre | 2015 |
A pilot in vivo proton magnetic resonance spectroscopy study of amino acid neurotransmitter response to ketamine treatment of major depressive disorder.
Topics: Adult; Amino Acids; Antidepressive Agents; Brain; Depressive Disorder, Major; Female; gamma-Aminobut | 2016 |
[On the Differential Diagnosis of Intractable Psychogenic Chronic Cough: Neuropathic Larynx Irritable - Gabapentin's Antitussive Action].
Topics: Aged; Amines; Avitaminosis; Chronic Disease; Cough; Cyclohexanecarboxylic Acids; Depressive Disorder | 2015 |
Altered GABA neurotransmission in major depressive disorder: Re-analyzing publicly available data.
Topics: Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Hippocampus; Humans; Male; Prefrontal C | 2016 |
A pilot integrative genomics study of GABA and glutamate neurotransmitter systems in suicide, suicidal behavior, and major depressive disorder.
Topics: Adult; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Gene Expression Regulation; Geno | 2016 |
Elevated prefrontal cortex GABA in patients with major depressive disorder after TMS treatment measured with proton magnetic resonance spectroscopy.
Topics: Adult; Aged; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; | 2016 |
Bidirectional Homeostatic Regulation of a Depression-Related Brain State by Gamma-Aminobutyric Acidergic Deficits and Ketamine Treatment.
Topics: Animals; Behavior, Animal; Depressive Disorder, Major; Down-Regulation; gamma-Aminobutyric Acid; Glu | 2016 |
Altered neuronal spontaneous activity correlates with glutamate concentration in medial prefrontal cortex of major depressed females: An fMRI-MRS study.
Topics: Adult; Antidepressive Agents; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Glutamic | 2016 |
Prefrontal inositol levels and implicit decision-making in healthy individuals and depressed patients.
Topics: Adult; Aspartic Acid; Decision Making; Delay Discounting; Depressive Disorder, Major; Diagnostic and | 2016 |
Antidepressant-like effects of ascorbic acid and ketamine involve modulation of GABAA and GABAB receptors.
Topics: Animals; Antidepressive Agents; Ascorbic Acid; Depression; Depressive Disorder, Major; Disease Model | 2016 |
Whole-transcriptome brain expression and exon-usage profiling in major depression and suicide: evidence for altered glial, endothelial and ATPase activity.
Topics: Adenosine Triphosphatases; Adult; Aged; Brain; Case-Control Studies; Depressive Disorder, Major; End | 2017 |
Development of psychopathology in deployed armed forces in relation to plasma GABA levels.
Topics: Adult; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Humans; Male; Military Personnel | 2016 |
Impaired GABA synthesis, uptake and release are associated with depression-like behaviors induced by chronic mild stress.
Topics: Animals; Axons; Depressive Disorder, Major; gamma-Aminobutyric Acid; Humans; Male; Mice; Mice, Inbre | 2016 |
The effects of electroconvulsive therapy on GABAergic function in major depressive patients.
Topics: Adult; Baclofen; Depressive Disorder, Major; Electroconvulsive Therapy; Female; GABA Agonists; gamma | 2008 |
Proton MR spectroscopy of the hippocampus at 3 T in patients with unipolar major depressive disorder: correlates and predictors of treatment response.
Topics: Adult; Aspartic Acid; Case-Control Studies; Choline; Depressive Disorder, Major; Female; gamma-Amino | 2009 |
Amino acid neurotransmitters assessed by proton magnetic resonance spectroscopy: relationship to treatment resistance in major depressive disorder.
Topics: Adult; Brain; Case-Control Studies; Depressive Disorder, Major; Drug Resistance; Female; gamma-Amino | 2009 |
Pregabalin (Lyrica, Pfizer, Inc.).
Topics: Antidepressive Agents; Depressive Disorder, Major; gamma-Aminobutyric Acid; Humans; Pregabalin | 2009 |
The relationship between aberrant neuronal activation in the pregenual anterior cingulate, altered glutamatergic metabolism, and anhedonia in major depression.
Topics: Adult; Arousal; Aspartic Acid; Blood Glucose; Corpus Callosum; Depressive Disorder, Major; Dominance | 2009 |
Pregabalin augmentation to antidepressants in patients with major depressive disorder.
Topics: Adult; Analgesics; Antidepressive Agents; Depressive Disorder, Major; Drug Synergism; Female; gamma- | 2009 |
Global brain gene expression analysis links glutamatergic and GABAergic alterations to suicide and major depression.
Topics: Adult; Animals; Brain; Depressive Disorder, Major; gamma-Aminobutyric Acid; Gene Expression Profilin | 2009 |
Secondhand smoke exposure and depressive symptoms.
Topics: Air Pollution, Indoor; Chronic Disease; Cotinine; Depression; Depressive Disorder, Major; Environmen | 2010 |
High levels of Anti-GAD65 and Anti-Ro52 autoantibodies in a patient with major depressive disorder showing psychomotor disturbance.
Topics: Adult; Autoantibodies; Autoimmunity; Biomarkers; Brain; Brain Chemistry; Depressive Disorder, Major; | 2010 |
Increased ventricular lactate in chronic fatigue syndrome measured by 1H MRS imaging at 3.0 T. II: comparison with major depressive disorder.
Topics: Adult; Cerebral Ventricles; Depressive Disorder, Major; Fatigue Syndrome, Chronic; Female; gamma-Ami | 2010 |
Elevated cortical glutamate in young people at increased familial risk of depression.
Topics: Adolescent; Cerebral Cortex; Depression; Depressive Disorder; Depressive Disorder, Major; Family; Fe | 2011 |
The GABAergic deficit hypothesis of major depressive disorder.
Topics: Animals; Antidepressive Agents; Brain; Depressive Disorder, Major; Disease Models, Animal; gamma-Ami | 2011 |
The GABAergic deficit hypothesis of major depressive disorder.
Topics: Animals; Antidepressive Agents; Brain; Depressive Disorder, Major; Disease Models, Animal; gamma-Ami | 2011 |
The GABAergic deficit hypothesis of major depressive disorder.
Topics: Animals; Antidepressive Agents; Brain; Depressive Disorder, Major; Disease Models, Animal; gamma-Ami | 2011 |
The GABAergic deficit hypothesis of major depressive disorder.
Topics: Animals; Antidepressive Agents; Brain; Depressive Disorder, Major; Disease Models, Animal; gamma-Ami | 2011 |
The antidepressant effect of ketamine is not associated with changes in occipital amino acid neurotransmitter content as measured by [(1)H]-MRS.
Topics: Adult; Aged; Antidepressive Agents; Blood Pressure; Depressive Disorder, Major; Dissociative Disorde | 2011 |
The antidepressant effect of ketamine is not associated with changes in occipital amino acid neurotransmitter content as measured by [(1)H]-MRS.
Topics: Adult; Aged; Antidepressive Agents; Blood Pressure; Depressive Disorder, Major; Dissociative Disorde | 2011 |
The antidepressant effect of ketamine is not associated with changes in occipital amino acid neurotransmitter content as measured by [(1)H]-MRS.
Topics: Adult; Aged; Antidepressive Agents; Blood Pressure; Depressive Disorder, Major; Dissociative Disorde | 2011 |
The antidepressant effect of ketamine is not associated with changes in occipital amino acid neurotransmitter content as measured by [(1)H]-MRS.
Topics: Adult; Aged; Antidepressive Agents; Blood Pressure; Depressive Disorder, Major; Dissociative Disorde | 2011 |
The antidepressant effect of ketamine is not associated with changes in occipital amino acid neurotransmitter content as measured by [(1)H]-MRS.
Topics: Adult; Aged; Antidepressive Agents; Blood Pressure; Depressive Disorder, Major; Dissociative Disorde | 2011 |
The antidepressant effect of ketamine is not associated with changes in occipital amino acid neurotransmitter content as measured by [(1)H]-MRS.
Topics: Adult; Aged; Antidepressive Agents; Blood Pressure; Depressive Disorder, Major; Dissociative Disorde | 2011 |
The antidepressant effect of ketamine is not associated with changes in occipital amino acid neurotransmitter content as measured by [(1)H]-MRS.
Topics: Adult; Aged; Antidepressive Agents; Blood Pressure; Depressive Disorder, Major; Dissociative Disorde | 2011 |
The antidepressant effect of ketamine is not associated with changes in occipital amino acid neurotransmitter content as measured by [(1)H]-MRS.
Topics: Adult; Aged; Antidepressive Agents; Blood Pressure; Depressive Disorder, Major; Dissociative Disorde | 2011 |
The antidepressant effect of ketamine is not associated with changes in occipital amino acid neurotransmitter content as measured by [(1)H]-MRS.
Topics: Adult; Aged; Antidepressive Agents; Blood Pressure; Depressive Disorder, Major; Dissociative Disorde | 2011 |
Suicide by gabapentin overdose.
Topics: Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Depressive Disorder, Major; Drug Overdose; Fem | 2011 |
Anterior cingulate cortex γ-aminobutyric acid in depressed adolescents: relationship to anhedonia.
Topics: Adolescent; Anhedonia; Case-Control Studies; Child; Cross-Sectional Studies; Depressive Disorder, Ma | 2012 |
An investigation of amino-acid neurotransmitters as potential predictors of clinical improvement to ketamine in depression.
Topics: Adult; Cerebral Cortex; Depressive Disorder, Major; Excitatory Amino Acid Antagonists; Female; gamma | 2012 |
Reduced γ-aminobutyric acid in occipital and anterior cingulate cortices in primary insomnia: a link to major depressive disorder?
Topics: Actigraphy; Adult; Brain Mapping; Case-Control Studies; Creatine; Depressive Disorder, Major; Female | 2012 |
Gene expression of GABA and glutamate pathway markers in the prefrontal cortex of non-suicidal elderly depressed patients.
Topics: Aged; Aged, 80 and over; Bipolar Disorder; Depressive Disorder, Major; Female; gamma-Aminobutyric Ac | 2012 |
[Decreased occipital GABA concentrations in patients with first-episode major depressive disorder: a magnetic resonance spectroscopy study].
Topics: Adolescent; Adult; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Humans; Magnetic Res | 2012 |
Brain-derived neurotrophic factor signaling and subgenual anterior cingulate cortex dysfunction in major depressive disorder.
Topics: Animals; Brain-Derived Neurotrophic Factor; Case-Control Studies; Depressive Disorder, Major; Domina | 2012 |
Adjunctive pregabalin in partial responders with major depressive disorder and residual anxiety.
Topics: Adrenergic Agents; Aged; Anti-Anxiety Agents; Anxiety; Depressive Disorder, Major; Female; gamma-Ami | 2013 |
Evidence for increased glutamatergic cortical facilitation in children and adolescents with major depressive disorder.
Topics: Adolescent; Case-Control Studies; Cerebral Cortex; Child; Cross-Sectional Studies; Depressive Disord | 2013 |
Reduced GAD(65/67) immunoreactivity in the hypothalamic paraventricular nucleus in depression: a postmortem study.
Topics: Adult; Aged; Aged, 80 and over; Autopsy; Bipolar Disorder; Corticotropin-Releasing Hormone; Depressi | 2013 |
Influence of genetic polymorphisms in the glutamatergic and GABAergic systems and their interactions with environmental stressors on antidepressant response.
Topics: Adolescent; Adult; Antidepressive Agents; Depressive Disorder, Major; Female; gamma-Aminobutyric Aci | 2013 |
Gabapentin and posttraumatic stress disorder.
Topics: Acetates; Adult; Amines; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Cyclohexanec | 2003 |
Cerebral benzodiazepine receptors in depressed patients measured with [123I]iomazenil SPECT.
Topics: Adult; Binding Sites; Brain; Depressive Disorder, Major; Female; Flumazenil; gamma-Aminobutyric Acid | 2003 |
Normal prefrontal gamma-aminobutyric acid levels in remitted depressed subjects determined by proton magnetic resonance spectroscopy.
Topics: Adult; Antidepressive Agents; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Glutamic | 2005 |
Cortical gamma-aminobutyric acid concentrations in depressed patients receiving cognitive behavioral therapy.
Topics: Adult; Cognitive Behavioral Therapy; Depressive Disorder, Major; Electroconvulsive Therapy; Female; | 2006 |
Evidence for impaired cortical inhibition in patients with unipolar major depression.
Topics: Adult; Brain Mapping; Cerebral Cortex; Depressive Disorder, Major; Dominance, Cerebral; Electromyogr | 2006 |
Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression.
Topics: Bipolar Disorder; Cerebral Cortex; Depressive Disorder, Major; Excitatory Amino Acid Transporter 1; | 2005 |
Changes in plasma amino acids after electroconvulsive therapy of depressed patients.
Topics: Adult; Aged; Aspartic Acid; Depressive Disorder, Major; Electroconvulsive Therapy; Electroencephalog | 2005 |
Behavioral correlates of GABAergic disruption in Alzheimer's disease.
Topics: Affect; Aged; Aged, 80 and over; Aggression; Alzheimer Disease; Cognition Disorders; Depressive Diso | 2007 |
Relationship between posttrauma GABA plasma levels and PTSD at 1-year follow-up.
Topics: Accidents, Traffic; Adolescent; Adult; Aged; Biomarkers; Cohort Studies; Depressive Disorder, Major; | 2006 |
GABAergic neurons immunoreactive for calcium binding proteins are reduced in the prefrontal cortex in major depression.
Topics: Adult; Aged; Biomarkers; Calbindins; Calcium-Binding Proteins; Cell Count; Cell Size; Depressive Dis | 2007 |
Reduced prefrontal glutamate/glutamine and gamma-aminobutyric acid levels in major depression determined using proton magnetic resonance spectroscopy.
Topics: Adult; Ambulatory Care; Cell Count; Cross-Sectional Studies; Depressive Disorder, Major; Female; gam | 2007 |
Patterns of gene expression in the limbic system of suicides with and without major depression.
Topics: Amygdala; Case-Control Studies; Depressive Disorder, Major; gamma-Aminobutyric Acid; Gene Expression | 2007 |
Low GABA concentrations in occipital cortex and anterior cingulate cortex in medication-free, recovered depressed patients.
Topics: Adult; Case-Control Studies; Creatine; Depressive Disorder, Major; Down-Regulation; Feasibility Stud | 2008 |
Altered expression of genes involved in ATP biosynthesis and GABAergic neurotransmission in the ventral prefrontal cortex of suicides with and without major depression.
Topics: Adenosine Triphosphate; Adolescent; Adult; Analysis of Variance; Case-Control Studies; Depressive Di | 2009 |
SPECT and neuropsychological performance in severe depression treated with ECT.
Topics: Adult; Brain; Cerebral Cortex; Depressive Disorder, Major; Dominance, Cerebral; Electroconvulsive Th | 2001 |
The density and spatial distribution of GABAergic neurons, labelled using calcium binding proteins, in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia.
Topics: Adult; Bipolar Disorder; Calcium-Binding Proteins; Cell Count; Depressive Disorder, Major; Female; g | 2002 |
Increased occipital cortex GABA concentrations in depressed patients after therapy with selective serotonin reuptake inhibitors.
Topics: Adult; Depressive Disorder, Major; Female; Follow-Up Studies; gamma-Aminobutyric Acid; Humans; Magne | 2002 |