gamma-aminobutyric acid and Day Blindness studies

gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.

Research Excerpts

Excerpt	Relevance	Reference
"Charles Bonnet syndrome is a condition characterised by the presence of visual hallucinations in patients having visual impairment most commonly reported in the seventh decade."	5.39	Pregabalin in the treatment of Charles Bonnet syndrome. ( Bokdawala, RA; Sawant, NS, 2013)
"Vigabatrin use in some epilepsy patients has been associated with persistent visual field constriction and retinal dysfunction."	3.71	GABA and the ornithine delta-aminotransferase gene in vigabatrin-associated visual field defects. ( Felice, K; Hisama, FM; Lee, HH; Mattson, RH; Petroff, OA, 2001)
" Reported adverse effects were also analysed."	2.47	Efficacy and safety of perioperative pregabalin for post-operative pain: a meta-analysis of randomized-controlled trials. ( Cateloy, F; Engelman, E, 2011)
"Visual impairment is one of the most feared complications of Type 2 Diabetes Mellitus."	1.46	Diabetic brain or retina? Visual psychophysical performance in diabetic patients in relation to GABA levels in occipital cortex. ( Abuhaiba, SI; Castelo-Branco, M; d'Almeida, OC; Gomes, L; Guelho, D; Moreno, C; Quendera, B; Sanches, M, 2017)
" Removal of this potential adverse effect with adjuvant intervention(s) would represent a significant advance in epilepsy therapeutics."	1.46	Aberrant mTOR signaling and disrupted autophagy: The missing link in potential vigabatrin-associated ocular toxicity? ( Ainslie, GR; Gibson, KM; Pearl, PL; Vogel, KR, 2017)
"VGB is effective in treating infantile spasms, a rare seizure disorder associated with significant morbidity."	1.46	Aberrant mTOR signaling and disrupted autophagy: The missing link in potential vigabatrin-associated ocular toxicity? ( Ainslie, GR; Gibson, KM; Pearl, PL; Vogel, KR, 2017)
"Charles Bonnet syndrome is a condition characterised by the presence of visual hallucinations in patients having visual impairment most commonly reported in the seventh decade."	1.39	Pregabalin in the treatment of Charles Bonnet syndrome. ( Bokdawala, RA; Sawant, NS, 2013)
"Vigabatrin (VGB) is an irreversible inhibitor of gamma-aminobutyric acid (GABA) transaminase."	1.32	Acute vigabatrin retinotoxicity in albino rats depends on light but not GABA. ( Benz, AM; Ishikawa, M; Izumi, M; Izumi, Y; Thio, LL; Zorumski, CF, 2004)
" Five hundred micromolar GABA and 50 microM tiagabine were not toxic in the presence or absence of light."	1.32	Acute vigabatrin retinotoxicity in albino rats depends on light but not GABA. ( Benz, AM; Ishikawa, M; Izumi, M; Izumi, Y; Thio, LL; Zorumski, CF, 2004)
"Vigabatrin is an extremely effective antiepileptic drug that selectively increases brain gamma-aminobutyric acid (GABA)."	1.30	Vigabatrin-associated retinal cone system dysfunction: electroretinogram and ophthalmologic findings. ( Johnson, MA; Krauss, GL; Miller, NR, 1998)

Research

Studies (41)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Time to First Analgesia

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	24 (58.54)	18.2507
2000's	7 (17.07)	29.6817
2010's	10 (24.39)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Sanches, M	1
Abuhaiba, SI	1
d'Almeida, OC	1
Quendera, B	1
Gomes, L	1
Moreno, C	1
Guelho, D	1
Castelo-Branco, M	1
Androsova, G	1
Krause, R	1
Borghei, M	1
Wassenaar, M	1
Auce, P	1
Avbersek, A	1
Becker, F	1
Berghuis, B	1
Campbell, E	1
Coppola, A	1
Francis, B	1
Wolking, S	1
Cavalleri, GL	1
Craig, J	1
Delanty, N	1
Koeleman, BPC	1
Kunz, WS	1
Lerche, H	1
Marson, AG	1
Sander, JW	3
Sills, GJ	1
Striano, P	1
Zara, F	1
Sisodiya, SM	1
Depondt, C	1
Shi, J	1
Li, Q	1
Wen, T	1
Sawant, NS	1
Bokdawala, RA	1
Nair, AG	2
Shah, BR	1
Gandhi, RA	1
Park, IJ	1
Kim, G	1
Ko, G	1
Lee, YJ	1
Hwang, SH	1
Kim, JY	1
Kim, DG	1
Kim, SH	2
Kwon, OW	1
You, YS	1
Vogel, KR	1
Ainslie, GR	1
Pearl, PL	1
Gibson, KM	1
Lang, B	1
Zhao, L	1
Cai, L	1
McKie, L	1
Forrester, JV	1
McCaig, CD	1
Jackson, IJ	1
Shen, S	1
Engelman, E	1
Cateloy, F	1
Izumi, Y	1
Ishikawa, M	1
Benz, AM	1
Izumi, M	1
Zorumski, CF	1
Thio, LL	1
Straube, A	1
Arndt, CF	1
Husson, J	1
Derambure, P	1
Hache, JC	1
Arnaud, B	1
Defoort-Dhellemmes, S	1
Tilz, C	1
Wang-Tilz, Y	1
Jünemann, A	1
Stefan, H	2
Michelson, G	1
Hayreh, SS	1
Raman, R	1
Choudhari, NS	1
Leigh, RJ	2
Averbuch-Heller, L	2
Tomsak, RL	1
Remler, BF	1
Yaniglos, SS	1
Dell'Osso, LF	1
Eke, T	1
Talbot, JF	1
Lawden, MC	1
Wilson, EA	1
Brodie, MJ	1
Wong, IC	1
Mawer, GE	1
Blackwell, N	1
Hayllar, J	1
Kelly, G	1
Harding, GF	2
Backstrom, JT	1
Hinkle, RL	1
Flicker, MR	1
Bodis-Wollner, I	1
Mackenzie, R	1
Klistorner, A	1
Krauss, GL	1
Johnson, MA	1
Miller, NR	1
Ruether, K	1
Pung, T	1
Kellner, U	1
Schmitz, B	1
Hartmann, C	1
Seeliger, M	1
Rao, GP	1
Fat, FA	1
Kyle, G	1
Leach, JP	1
Chadwick, DW	1
Batterbury, M	1
Baulac, M	1
Nordmann, JP	1
Lanoé, Y	1
Appleton, RE	1
Beck, RW	1
Brigell, MG	1
Roubertie, A	1
Bellet, H	1
Echenne, B	1
Lhatoo, SD	1
Bernatik, J	1
Knorr, J	1
Roubergue, A	1
Pelosse, B	1
Doummar, D	1
Beauvais, P	1
Montchilova, M	1
Gonthier, B	1
Billette de Villemeur, T	1
Daneshvar, H	1
Racette, L	1
Coupland, SG	1
Kertes, PJ	1
Guberman, A	1
Zackon, D	1
Stahl, JS	1
Rottach, KG	1
von Maydell, RD	1
Collins, SD	1
Hisama, FM	1
Mattson, RH	1
Lee, HH	1
Felice, K	1
Petroff, OA	1
Elder, MJ	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Effects of Pre-operative Oral Pregabalin on Post Operative Morphine Consumption After Abdominal Hysterectomy With/Without Salpingo-oophorectomy Under Spinal Anesthesia With Intrathecal Morphine[NCT02285010]	Phase 4	125 participants (Actual)	Interventional	2014-11-30	Completed
The Effect of Reducing the Intraocular Pressure by Using Alphagan Drops and Macular Edema in Patients With Diabetic Macular Edema[NCT02718547]		25 participants (Anticipated)	Interventional	2017-03-26	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Time to first analgesia is recorded from IV PCA. (NCT02285010)
Timeframe: 24 hours

Pain Scores on the Visual Analog Scale

Intervention	hour (Median)
Placebo	4.6
Pregabalin	7.7

"Pain score is evaluated by nurses using Numerical Rating Scale (NRS)~Minimum score 0 (no pain), Maximum score 10 (worst imaginable pain), lower scores mean a better outcome" (NCT02285010)
Timeframe: 24 hours

Post Operative Morphine Consumption

Intervention	score on a scale (Median)
	At rest	At movement
Placebo	2	4
Pregabalin	2	4

Cumulative morphine consumption in the first 24 hours is recorded from IV PCA (NCT02285010)
Timeframe: 6, 12, and 24 hours after operation

Numbers of Participants With Adverse Events as a Measure of Safety and Tolerability

Intervention	mg (Median)
	Morphine consumption 6 hr	Morphine consumption 12 hr	Morphine consumption 24 hr
Placebo	1	1	4
Pregabalin	0	1	5

Measure sedation score by evaluate and observe; measure pruritus, PONV, dizziness, visual disturbance using questionnaire (NCT02285010)
Timeframe: 24 hours

Article	Year
Does preoperative administration of gabapentin/pregabalin improve postoperative nasal surgery pain? The Laryngoscope, 2016, Volume: 126, Issue:10 Topics: Adolescent; Adult; Amines; Analgesics; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminob	2016
Efficacy and safety of perioperative pregabalin for post-operative pain: a meta-analysis of randomized-controlled trials. Acta anaesthesiologica Scandinavica, 2011, Volume: 55, Issue:8 Topics: Analgesics; Analgesics, Opioid; Confusion; Dizziness; Dose-Response Relationship, Drug; Endpoint Det	2011
Pharmacology of vertigo/nystagmus/oscillopsia. Current opinion in neurology, 2005, Volume: 18, Issue:1 Topics: Amines; Benzodiazepines; Cyclohexanecarboxylic Acids; Excitatory Amino Acid Antagonists; GABA Agonis	2005
Treatment of abnormal eye movements that impair vision: strategies based on current concepts of physiology and pharmacology. Annals of neurology, 1994, Volume: 36, Issue:2 Topics: Animals; Clinical Trials as Topic; Double-Blind Method; Eye; Eye Movements; Fixation, Ocular; GABA A	1994

Article	Year
Diabetic brain or retina? Visual psychophysical performance in diabetic patients in relation to GABA levels in occipital cortex. Metabolic brain disease, 2017, Volume: 32, Issue:3 Topics: Adult; Aged; Brain; Cohort Studies; Diabetes Mellitus, Type 2; Female; gamma-Aminobutyric Acid; Huma	2017
Comparative effectiveness of antiepileptic drugs in patients with mesial temporal lobe epilepsy with hippocampal sclerosis. Epilepsia, 2017, Volume: 58, Issue:10 Topics: Adolescent; Adult; Aged; Amines; Anticonvulsants; Ataxia; Benzodiazepines; Carbamazepine; Clobazam;	2017
Dendritic Cell Factor 1-Knockout Results in Visual Deficit Through the GABA System in Mouse Primary Visual Cortex. Neuroscience bulletin, 2018, Volume: 34, Issue:3 Topics: Animals; Brain Waves; Disease Models, Animal; Electroencephalography; gamma-Aminobutyric Acid; Gene	2018
Pregabalin in the treatment of Charles Bonnet syndrome. JPMA. The Journal of the Pakistan Medical Association, 2013, Volume: 63, Issue:4 Topics: Analgesics; Diabetic Neuropathies; Diabetic Retinopathy; Female; gamma-Aminobutyric Acid; Hallucinat	2013
Seeing the unseen: Charles Bonnet syndrome revisited. Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society, 2015, Volume: 15, Issue:3 Topics: Aged; Amines; Awareness; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyric Acid; H	2015
Macular Edema after Gabapentin. Korean journal of ophthalmology : KJO, 2016, Volume: 30, Issue:2 Topics: Aged; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Fluorescein Angiography; Gabapentin; gam	2016
Aberrant mTOR signaling and disrupted autophagy: The missing link in potential vigabatrin-associated ocular toxicity? Clinical pharmacology and therapeutics, 2017, Volume: 101, Issue:4 Topics: Anticonvulsants; Autophagy; Evoked Potentials, Visual; gamma-Aminobutyric Acid; Humans; Infant; Infa	2017
GABAergic amacrine cells and visual function are reduced in PAC1 transgenic mice. Neuropharmacology, 2010, Volume: 58, Issue:1 Topics: Amacrine Cells; Animals; Animals, Newborn; Bromodeoxyuridine; Cell Death; Cyclin-Dependent Kinase In	2010
Acute vigabatrin retinotoxicity in albino rats depends on light but not GABA. Epilepsia, 2004, Volume: 45, Issue:9 Topics: Acute Disease; Animals; Anticonvulsants; Darkness; gamma-Aminobutyric Acid; Light; Male; Nipecotic A	2004
Retinal electrophysiological results in patients receiving lamotrigine monotherapy. Epilepsia, 2005, Volume: 46, Issue:7 Topics: Adolescent; Adult; Anticonvulsants; Child; Electrooculography; Electroretinography; Epilepsies, Part	2005
Visual field defect during therapy with valproic-acid. European journal of neurology, 2007, Volume: 14, Issue:8 Topics: Adult; Epilepsy; Female; GABA Agents; gamma-Aminobutyric Acid; Humans; Retina; Retinal Degeneration;	2007
Role of retinal hypoxia in diabetic macular edema: a new concept. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2008, Volume: 246, Issue:3 Topics: Adult; Blood Pressure; Diabetic Nephropathies; Diabetic Retinopathy; Female; Fluorescein Angiography	2008
Central retinal vein occlusion with non-arteritic ischemic optic neuropathy and cystoid macular edema. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2008, Volume: 246, Issue:8 Topics: Blood Pressure; Diabetic Retinopathy; Fluorescein Angiography; gamma-Aminobutyric Acid; Humans; Hypo	2008
Severe persistent visual field constriction associated with vigabatrin. BMJ (Clinical research ed.), 1997, Jan-18, Volume: 314, Issue:7075 Topics: 4-Aminobutyrate Transaminase; Adult; Anticonvulsants; Female; gamma-Aminobutyric Acid; Humans; Male;	1997
Severe persistent visual field constriction associated with vigabatrin. Chronic refractory epilepsy may have role in causing these unusual lesions. BMJ (Clinical research ed.), 1997, Jun-07, Volume: 314, Issue:7095 Topics: Adult; Anticonvulsants; Chronic Disease; Epilepsy; gamma-Aminobutyric Acid; Humans; Male; Vigabatrin	1997
Severe persistent visual field constriction associated with vigabatrin. Reaction might be dose dependent. BMJ (Clinical research ed.), 1997, Jun-07, Volume: 314, Issue:7095 Topics: Adult; Anticonvulsants; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Humans; Male; Vig	1997
Severe persistent visual field constriction associated with vigabatrin. Patients taking vigabatrin should have regular visual field testing. BMJ (Clinical research ed.), 1997, Jun-07, Volume: 314, Issue:7095 Topics: Adult; Anticonvulsants; gamma-Aminobutyric Acid; Humans; Male; Vigabatrin; Vision Disorders; Vision	1997
Severe persistent visual field constriction associated with vigabatrin. Four possible explanations exist. BMJ (Clinical research ed.), 1997, Jun-07, Volume: 314, Issue:7095 Topics: Anticonvulsants; gamma-Aminobutyric Acid; Humans; Vigabatrin; Vision Disorders; Visual Fields	1997
Severe persistent visual field constriction associated with vigabatrin. Manufacturers have started several studies. BMJ (Clinical research ed.), 1997, Jun-07, Volume: 314, Issue:7095 Topics: Anticonvulsants; gamma-Aminobutyric Acid; Humans; Product Surveillance, Postmarketing; Vigabatrin; V	1997
Vision and neurodegenerative diseases. Vision research, 1997, Volume: 37, Issue:24 Topics: gamma-Aminobutyric Acid; Humans; Neural Pathways; Neurodegenerative Diseases; Nitric Oxide; Retina;	1997
Severe persistent visual field constriction associated with vigabatrin. Benefit: risk ratio must be calculated for individual patients. BMJ (Clinical research ed.), 1998, Jan-17, Volume: 316, Issue:7126 Topics: Anticonvulsants; gamma-Aminobutyric Acid; Humans; Risk Assessment; Vigabatrin; Vision Disorders; Vis	1998
Severe persistent visual field constriction associated with vigabatrin. Asymptomatic as well as symptomatic defects occur with vigabatrin. BMJ (Clinical research ed.), 1998, Jan-17, Volume: 316, Issue:7126 Topics: Adult; Anticonvulsants; Female; gamma-Aminobutyric Acid; Humans; Male; Vigabatrin; Vision Disorders;	1998
Vigabatrin-associated retinal cone system dysfunction: electroretinogram and ophthalmologic findings. Neurology, 1998, Volume: 50, Issue:3 Topics: Adult; Aged; Anticonvulsants; Electroretinography; Evoked Potentials, Visual; Female; gamma-Aminobut	1998
Electrophysiologic evaluation of a patient with peripheral visual field contraction associated with vigabatrin. Archives of ophthalmology (Chicago, Ill. : 1960), 1998, Volume: 116, Issue:6 Topics: Adolescent; Anticonvulsants; Electroretinography; Epilepsies, Partial; gamma-Aminobutyric Acid; Huma	1998
Study is needed of visual field defects associated with any long term antiepileptic drug. BMJ (Clinical research ed.), 1998, Jul-18, Volume: 317, Issue:7152 Topics: Anticoagulants; Enzyme Inhibitors; gamma-Aminobutyric Acid; Humans; Vigabatrin; Vision Disorders; Vi	1998
Severe visual-field constriction and side-effects of GABA-mimetic antiepileptic agents. Lancet (London, England), 1998, Aug-15, Volume: 352, Issue:9127 Topics: Anticonvulsants; Epilepsies, Myoclonic; Epilepsy, Tonic-Clonic; Female; Follow-Up Studies; GABA Agon	1998
Guideline may help in prescribing vigabatrin. BMJ (Clinical research ed.), 1998, Nov-07, Volume: 317, Issue:7168 Topics: Anticonvulsants; gamma-Aminobutyric Acid; Guidelines as Topic; Humans; Vigabatrin; Vision Disorders	1998
Vigabatrin-associated retinal cone system dysfunction. Neurology, 1998, Volume: 51, Issue:6 Topics: Anticonvulsants; Electroretinography; gamma-Aminobutyric Acid; Humans; Retinal Cone Photoreceptor Ce	1998
Vigabatrin-associated retinal cone system dysfunction. Neurology, 1998, Volume: 51, Issue:6 Topics: Anticonvulsants; gamma-Aminobutyric Acid; Humans; Retinal Cone Photoreceptor Cells; Vigabatrin; Visi	1998
Vigabatrin-associated retinal cone system dysfunction. Neurology, 1998, Volume: 51, Issue:6 Topics: Anticonvulsants; gamma-Aminobutyric Acid; Humans; Retinal Cone Photoreceptor Cells; Vigabatrin; Visi	1998
Infantile spasms and vigabatrin. Visual field defects may be permanent. BMJ (Clinical research ed.), 1999, Jan-02, Volume: 318, Issue:7175 Topics: Adult; Anticonvulsants; Child; gamma-Aminobutyric Acid; Humans; Infant; Practice Guidelines as Topic	1999
[Severe constriction of the visual field associated with vigabatrin discovered by thorough examination of a 17-year old girl]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 1999, Volume: 6, Issue:8 Topics: Adolescent; Anticonvulsants; Epilepsies, Partial; Female; gamma-Aminobutyric Acid; Hemiplegia; Human	1999
Symptomatic and asymptomatic visual loss in patients taking vigabatrin. Ophthalmology, 1999, Volume: 106, Issue:9 Topics: 4-Aminobutyrate Transaminase; Adult; Anticonvulsants; Electrooculography; Electroretinography; Enzym	1999
A pilot study of gabapentin as treatment for acquired nystagmus. Neuro-ophthalmology (Aeolus Press), 1996, Volume: 16, Issue:2 Topics: Acetates; Adult; Amines; Anticonvulsants; Brain Stem; Cerebrovascular Disorders; Cyclohexanecarboxyl	1996
GABA and the ornithine delta-aminotransferase gene in vigabatrin-associated visual field defects. Seizure, 2001, Volume: 10, Issue:7 Topics: Anticonvulsants; Brain; Epilepsy; gamma-Aminobutyric Acid; Genomic Library; Humans; Ornithine-Oxo-Ac	2001
Diazepam and its effects on visual fields. Australian and New Zealand journal of ophthalmology, 1992, Volume: 20, Issue:3 Topics: Aged; Diazepam; Female; gamma-Aminobutyric Acid; Humans; Retina; Vision Disorders; Visual Acuity; Vi	1992

gamma-aminobutyric acid and Day Blindness