gamma-aminobutyric acid has been researched along with Cryptogenic Infantile Spasms in 54 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Vigabatrin has been shown to be efficient in infants with infantile spasms and tuberous sclerosis, in open studies." | 9.08 | Randomized trial comparing vigabatrin and hydrocortisone in infantile spasms due to tuberous sclerosis. ( Chiron, C; Dulac, O; Dumas, C; Jambaqué, I; Mumford, J, 1997) |
| "The purpose of this report is to review the efficacy and safety of vigabatrin in the treatment of infantile spasms in infants suffering from tuberous sclerosis complex." | 8.80 | Vigabatrin in the treatment of infantile spasms in tuberous sclerosis: literature review. ( Hancock, E; Osborne, JP, 1999) |
| "We present the results of treatment with vigabatrin in the polytherapy of resistant infantile epilepsy." | 7.69 | [Treatment of refractory infantile epilepsy with vigabatrin in a series of 55 patients]. ( Hernández-Laín, A; López-Valdés, E; Mateos, F; Porta, J; Simón, R, 1996) |
| "Vigabatrin has been shown to be efficient in infants with infantile spasms and tuberous sclerosis, in open studies." | 6.68 | Randomized trial comparing vigabatrin and hydrocortisone in infantile spasms due to tuberous sclerosis. ( Chiron, C; Dulac, O; Dumas, C; Jambaqué, I; Mumford, J, 1997) |
| "Vigabatrin was most effective in cryptogenic and symptomatic partial seizures (39% and 43%, respectively), and in infantile spasms (25%)." | 6.68 | Vigabatrin as add-on therapy in children and adolescents with refractory epilepsy: an open trial. ( Coppola, G; Pascotto, A; Terraciano, AM, 1997) |
| "Of the 313 patients without tuberous sclerosis complex, 170 (54%) had complete cessation of their infantile spasms; of the 77 patients with tuberous sclerosis complex, 73 (95%) had complete cessation of their seizures." | 6.40 | Vigabatrin in the treatment of infantile spasms in tuberous sclerosis: literature review. ( Hancock, E; Osborne, JP, 1999) |
| "Vigabatrin is a specific and irreversible inhibitor of the enzyme gamma-amino-butyric-acid (GABA) transferase." | 6.39 | [Vigabatrin and lamotrigin: experiences with 2 new anticonvulsants in the Swiss epilepsy clinic]. ( Krämer, G; Vogt, H, 1995) |
| "1 %) and relative bioavailability (F) (26." | 5.40 | Population pharmacokinetics analysis of vigabatrin in adults and children with epilepsy and children with infantile spasms. ( Karim, A; Kowalski, KG; Nielsen, JC; Patel, M; Tolbert, D; Wesche, DL, 2014) |
| "Vigabatrin is an inhibitor of γ-aminobutyric acid transaminase." | 5.40 | Population pharmacokinetics analysis of vigabatrin in adults and children with epilepsy and children with infantile spasms. ( Karim, A; Kowalski, KG; Nielsen, JC; Patel, M; Tolbert, D; Wesche, DL, 2014) |
| "Vigabatrin pharmacokinetic data from six randomized controlled clinical trials and one open-label study were analyzed using nonlinear mixed-effects modeling." | 5.40 | Population pharmacokinetics analysis of vigabatrin in adults and children with epilepsy and children with infantile spasms. ( Karim, A; Kowalski, KG; Nielsen, JC; Patel, M; Tolbert, D; Wesche, DL, 2014) |
| " Covariate analysis indicated that age, creatinine clearance (CLCR), and body weight were important predictors of vigabatrin pharmacokinetic parameters." | 5.40 | Population pharmacokinetics analysis of vigabatrin in adults and children with epilepsy and children with infantile spasms. ( Karim, A; Kowalski, KG; Nielsen, JC; Patel, M; Tolbert, D; Wesche, DL, 2014) |
| "The model adequately described vigabatrin pharmacokinetic and enabled predictions of systemic exposures in pediatric patients 1-12 months of age." | 5.40 | Population pharmacokinetics analysis of vigabatrin in adults and children with epilepsy and children with infantile spasms. ( Karim, A; Kowalski, KG; Nielsen, JC; Patel, M; Tolbert, D; Wesche, DL, 2014) |
| "We report a 2-month-old male with West syndrome associated with infantile hypophosphatasia." | 5.32 | A successful treatment with pyridoxal phosphate for West syndrome in hypophosphatasia. ( Kamiyama, N; Miyamoto, Y; Murakami, H; Sasamoto, Y; Yamamoto, H, 2004) |
| "Vigabatrin has been shown to be efficient in infants with infantile spasms and tuberous sclerosis, in open studies." | 5.08 | Randomized trial comparing vigabatrin and hydrocortisone in infantile spasms due to tuberous sclerosis. ( Chiron, C; Dulac, O; Dumas, C; Jambaqué, I; Mumford, J, 1997) |
| "The purpose of this report is to review the efficacy and safety of vigabatrin in the treatment of infantile spasms in infants suffering from tuberous sclerosis complex." | 4.80 | Vigabatrin in the treatment of infantile spasms in tuberous sclerosis: literature review. ( Hancock, E; Osborne, JP, 1999) |
| "Seizures in a term infant with Ohtahara syndrome, associated with polymicrogyria, and a pre-term neonate with similar clinical features, failed to respond to conventional anticonvulsants, but were controlled with vigabatrin monotherapy." | 3.69 | Vigabatrin monotherapy in resistant neonatal seizures. ( Barwick, DD; Baxter, PS; Gardner-Medwin, D; Ince, P; Livingston, J; Murdoch-Eaton, D, 1995) |
| "We present the results of treatment with vigabatrin in the polytherapy of resistant infantile epilepsy." | 3.69 | [Treatment of refractory infantile epilepsy with vigabatrin in a series of 55 patients]. ( Hernández-Laín, A; López-Valdés, E; Mateos, F; Porta, J; Simón, R, 1996) |
| "Vigabatrin has been shown to be efficient in infants with infantile spasms and tuberous sclerosis, in open studies." | 2.68 | Randomized trial comparing vigabatrin and hydrocortisone in infantile spasms due to tuberous sclerosis. ( Chiron, C; Dulac, O; Dumas, C; Jambaqué, I; Mumford, J, 1997) |
| "Vigabatrin was given as the initial monotherapy at therapeutic dose of 50-100 mg/kg." | 2.68 | Vigabatrin as first line therapy in infantile spasms: review of seven patients. ( Kwong, L, 1997) |
| "Vigabatrin was most effective in cryptogenic and symptomatic partial seizures (39% and 43%, respectively), and in infantile spasms (25%)." | 2.68 | Vigabatrin as add-on therapy in children and adolescents with refractory epilepsy: an open trial. ( Coppola, G; Pascotto, A; Terraciano, AM, 1997) |
| "Autism and epilepsy are two associated disorders that are highly prevalent, share common developmental origins, and demonstrate substantial heritability." | 2.53 | Cortical interneuron dysfunction in epilepsy associated with autism spectrum disorders. ( Jacob, J, 2016) |
| "In particular, interictal spikes and seizures, especially if prolonged or frequent, may cause acute or long-lasting effects on brain functioning and development, which may impair performance in a variety of behavioral tests." | 2.45 | The epileptic hypothesis: developmentally related arguments based on animal models. ( Galanopoulou, AS; Moshé, SL, 2009) |
| "Of the 313 patients without tuberous sclerosis complex, 170 (54%) had complete cessation of their infantile spasms; of the 77 patients with tuberous sclerosis complex, 73 (95%) had complete cessation of their seizures." | 2.40 | Vigabatrin in the treatment of infantile spasms in tuberous sclerosis: literature review. ( Hancock, E; Osborne, JP, 1999) |
| "Vigabatrin (VGB) is a structural analogue of the inhibitory neurotransmitter gamma-amino butyric acid (GABA), which produces its antiepileptic effect by irreversibly inhibiting the degradative enzyme GABA-transaminase." | 2.40 | Vigabatrin. ( French, JA, 1999) |
| "By contrast West syndrome is easier to evaluate as the spasms are the only, and characteristic, seizure type." | 2.39 | Vigabatrin in the management of generalized seizures in children. ( Appleton, RE, 1995) |
| "Data from published research were extracted and evaluated according to study design, sample size, dosing regimen, outcome measures, and treatment efficacy and safety." | 2.39 | Treatment of infantile spasms. ( Casto, DT; Haines, ST, 1994) |
| "Vigabatrin has been used as both add-on, and monotherapy in the treatment of spasms." | 2.39 | Vigabatrin in the management of generalized seizures in children. ( Appleton, RE, 1995) |
| "Vigabatrin is a specific and irreversible inhibitor of the enzyme gamma-amino-butyric-acid (GABA) transferase." | 2.39 | [Vigabatrin and lamotrigin: experiences with 2 new anticonvulsants in the Swiss epilepsy clinic]. ( Krämer, G; Vogt, H, 1995) |
| "VGB is effective in treating infantile spasms, a rare seizure disorder associated with significant morbidity." | 1.46 | Aberrant mTOR signaling and disrupted autophagy: The missing link in potential vigabatrin-associated ocular toxicity? ( Ainslie, GR; Gibson, KM; Pearl, PL; Vogel, KR, 2017) |
| " Removal of this potential adverse effect with adjuvant intervention(s) would represent a significant advance in epilepsy therapeutics." | 1.46 | Aberrant mTOR signaling and disrupted autophagy: The missing link in potential vigabatrin-associated ocular toxicity? ( Ainslie, GR; Gibson, KM; Pearl, PL; Vogel, KR, 2017) |
| "West syndrome is the triad of infantile spasms, interictal hypsarrhythmia, and mental retardation." | 1.46 | Rapid whole-genome sequencing identifies a novel ( Batalov, S; Chowdhury, S; Dimmock, DM; Farnaes, L; Kingsmore, SF; Nahas, SA; Nelson, J, 2017) |
| "Vigabatrin is an inhibitor of γ-aminobutyric acid transaminase." | 1.40 | Population pharmacokinetics analysis of vigabatrin in adults and children with epilepsy and children with infantile spasms. ( Karim, A; Kowalski, KG; Nielsen, JC; Patel, M; Tolbert, D; Wesche, DL, 2014) |
| "Vigabatrin pharmacokinetic data from six randomized controlled clinical trials and one open-label study were analyzed using nonlinear mixed-effects modeling." | 1.40 | Population pharmacokinetics analysis of vigabatrin in adults and children with epilepsy and children with infantile spasms. ( Karim, A; Kowalski, KG; Nielsen, JC; Patel, M; Tolbert, D; Wesche, DL, 2014) |
| "The model adequately described vigabatrin pharmacokinetic and enabled predictions of systemic exposures in pediatric patients 1-12 months of age." | 1.40 | Population pharmacokinetics analysis of vigabatrin in adults and children with epilepsy and children with infantile spasms. ( Karim, A; Kowalski, KG; Nielsen, JC; Patel, M; Tolbert, D; Wesche, DL, 2014) |
| "1 %) and relative bioavailability (F) (26." | 1.40 | Population pharmacokinetics analysis of vigabatrin in adults and children with epilepsy and children with infantile spasms. ( Karim, A; Kowalski, KG; Nielsen, JC; Patel, M; Tolbert, D; Wesche, DL, 2014) |
| " Covariate analysis indicated that age, creatinine clearance (CLCR), and body weight were important predictors of vigabatrin pharmacokinetic parameters." | 1.40 | Population pharmacokinetics analysis of vigabatrin in adults and children with epilepsy and children with infantile spasms. ( Karim, A; Kowalski, KG; Nielsen, JC; Patel, M; Tolbert, D; Wesche, DL, 2014) |
| "We report a 2-month-old male with West syndrome associated with infantile hypophosphatasia." | 1.32 | A successful treatment with pyridoxal phosphate for West syndrome in hypophosphatasia. ( Kamiyama, N; Miyamoto, Y; Murakami, H; Sasamoto, Y; Yamamoto, H, 2004) |
| "The gamma-aminobutyric acid (GABA) system plays an important role in the early development of the hippocampal formation." | 1.31 | Development of GABAergic neurons and their transporter in human temporal cortex. ( Hachiya, Y; Takashima, S, 2001) |
| "EEG showed typical hypsarrhythmia in 8 cases, asymmetrical hypsarrhythmia in 1 case and modified hypsarrhythmia in another case." | 1.30 | [West's syndrome in patients with cerebral paralysis and periventricular leukomalacia: a good response to treatment]. ( Caraballo, R; Cersósimo, R; Fejerman, N; Intruvini, S; Pociecha, J, 1997) |
| "Vigabatrin (VGB) was specifically synthesized to enhance inhibitory GABAergic transmission by elevating GABA levels via irreversible inhibition of GABA transaminase." | 1.30 | [Monotherapy with vigabatrin in the treatment of West's syndrome]. ( Castro, E; Ocaña, O; Rufo, M; Santiago, C, 1997) |
| " Four of the six partial clinical responders had deterioration of spasms with additional VGB dosage increases." | 1.30 | Vigabatrin in the treatment of infantile spasms. ( Koo, B, 1999) |
| "ACTH is the standard treatment for infantile spasms (IS) in North America." | 1.30 | ACTH versus vigabatrin therapy in infantile spasms: a retrospective study. ( Carmant, L; Cossette, P; Riviello, JJ, 1999) |
| "The types of seizure patterns were classed as major (including focal) and minor (akinetic, myoclonic and hypsarrhythmic) and the patients were followed for up to one year." | 1.24 | Trial of amino-oxyacetic acid, an anticonvulsant. ( McGREAL, DA; TIBBLES, JA, 1963) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (5.56) | 18.7374 |
| 1990's | 38 (70.37) | 18.2507 |
| 2000's | 5 (9.26) | 29.6817 |
| 2010's | 6 (11.11) | 24.3611 |
| 2020's | 2 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Tanenhaus, A | 1 |
| Stowe, T | 1 |
| Young, A | 1 |
| McLaughlin, J | 1 |
| Aeran, R | 1 |
| Lin, IW | 1 |
| Li, J | 1 |
| Hosur, R | 1 |
| Chen, M | 1 |
| Leedy, J | 1 |
| Chou, T | 1 |
| Pillay, S | 1 |
| Vila, MC | 1 |
| Kearney, JA | 1 |
| Moorhead, M | 1 |
| Belle, A | 1 |
| Tagliatela, S | 1 |
| Miljanovic, N | 1 |
| van Dijk, RM | 1 |
| Buchecker, V | 1 |
| Potschka, H | 1 |
| Farnaes, L | 1 |
| Nahas, SA | 1 |
| Chowdhury, S | 1 |
| Nelson, J | 1 |
| Batalov, S | 1 |
| Dimmock, DM | 1 |
| Kingsmore, SF | 1 |
| Kobayashi, K | 1 |
| Toda, Y | 1 |
| Nielsen, JC | 1 |
| Kowalski, KG | 1 |
| Karim, A | 1 |
| Patel, M | 1 |
| Wesche, DL | 1 |
| Tolbert, D | 1 |
| Jacob, J | 1 |
| Vogel, KR | 1 |
| Ainslie, GR | 1 |
| Pearl, PL | 1 |
| Gibson, KM | 1 |
| Jansen, LA | 1 |
| Peugh, LD | 1 |
| Ojemann, JG | 1 |
| Galanopoulou, AS | 1 |
| Moshé, SL | 1 |
| Edvardson, S | 1 |
| Baumann, AM | 1 |
| Mühlenhoff, M | 1 |
| Stephan, O | 1 |
| Kuss, AW | 1 |
| Shaag, A | 1 |
| He, L | 1 |
| Zenvirt, S | 1 |
| Tanzi, R | 1 |
| Gerardy-Schahn, R | 1 |
| Elpeleg, O | 1 |
| TIBBLES, JA | 1 |
| McGREAL, DA | 1 |
| Yamamoto, H | 1 |
| Sasamoto, Y | 1 |
| Miyamoto, Y | 1 |
| Murakami, H | 1 |
| Kamiyama, N | 1 |
| Ito, M | 1 |
| Mikawa, H | 1 |
| Taniguchi, T | 1 |
| Appleton, RE | 3 |
| Baxter, PS | 1 |
| Gardner-Medwin, D | 1 |
| Barwick, DD | 1 |
| Ince, P | 1 |
| Livingston, J | 1 |
| Murdoch-Eaton, D | 1 |
| Vogt, H | 1 |
| Krämer, G | 1 |
| Haines, ST | 1 |
| Casto, DT | 1 |
| Schmitt, B | 2 |
| Wohlrab, G | 2 |
| Boltshauser, E | 2 |
| Backström, M | 1 |
| Eriksson, K | 1 |
| Koivikko, M | 1 |
| Aicardi, J | 1 |
| Mumford, JP | 1 |
| Dumas, C | 2 |
| Wood, S | 1 |
| López-Valdés, E | 1 |
| Hernández-Laín, A | 1 |
| Simón, R | 1 |
| Porta, J | 1 |
| Mateos, F | 1 |
| Kurlemann, G | 2 |
| Deufel, T | 1 |
| Schuierer, G | 1 |
| Gerster, H | 1 |
| Chiron, C | 2 |
| Jambaqué, I | 1 |
| Mumford, J | 1 |
| Dulac, O | 2 |
| Kwong, L | 1 |
| Spreafico, R | 1 |
| Angelini, L | 1 |
| Mastrangelo, M | 1 |
| Rizzuti, T | 1 |
| Bugiani, O | 1 |
| Avanzini, G | 1 |
| Caraballo, R | 1 |
| Cersósimo, R | 1 |
| Intruvini, S | 1 |
| Pociecha, J | 1 |
| Fejerman, N | 1 |
| Rufo, M | 1 |
| Santiago, C | 1 |
| Castro, E | 1 |
| Ocaña, O | 1 |
| Coppola, G | 1 |
| Terraciano, AM | 1 |
| Pascotto, A | 1 |
| Vigevano, F | 1 |
| Cilio, MR | 1 |
| Dooley, J | 1 |
| Gordon, K | 1 |
| Dooley, K | 1 |
| Siemes, H | 1 |
| Brandl, U | 1 |
| Spohr, HL | 1 |
| Völger, S | 1 |
| Weschke, B | 1 |
| Villeneuve, N | 1 |
| Soufflet, C | 1 |
| Plouin, P | 1 |
| Osborne, JP | 2 |
| Edwards, SW | 1 |
| Hancock, E | 2 |
| Lux, AL | 1 |
| O'Callaghan, F | 1 |
| Johnson, T | 1 |
| Kennedy, CR | 1 |
| Newton, RW | 1 |
| Verity, CM | 1 |
| Lhatoo, SD | 1 |
| Sander, JW | 1 |
| Koo, B | 1 |
| Sankar, R | 1 |
| Wasterlain, CG | 1 |
| Cossette, P | 1 |
| Riviello, JJ | 1 |
| Carmant, L | 1 |
| Roubergue, A | 1 |
| Schlumberger, ME | 1 |
| Billette de Villemeur, T | 1 |
| Granström, ML | 1 |
| Gaily, E | 1 |
| Liukkonen, E | 1 |
| Pellock, JM | 1 |
| Appleton, R | 1 |
| French, JA | 1 |
| Engelborghs, S | 1 |
| D'Hooge, R | 1 |
| De Deyn, PP | 1 |
| Hachiya, Y | 1 |
| Takashima, S | 1 |
| Meldrum, BS | 1 |
| Anlezark, G | 1 |
| Balzamo, E | 1 |
| Horton, RW | 1 |
| Trimble, M | 1 |
| Airaksinen, E | 1 |
| Tuomisto, L | 1 |
| Riikonen, R | 1 |
| Dubowitz, LM | 1 |
| Bouza, H | 1 |
| Hird, MF | 1 |
| Jaeken, J | 1 |
| Menges, EM | 1 |
| Palm, DG | 1 |
| Korinthenberg, R | 1 |
| Schultze, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Vigabatrin With High Dose Prednisolone Combination Therapy Versus Vigabatrin Alone for Infantile Spasm: a Randomized Trial[NCT04302116] | 250 participants (Anticipated) | Interventional | 2020-05-18 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
11 reviews available for gamma-aminobutyric acid and Cryptogenic Infantile Spasms
| Article | Year |
|---|---|
Cortical interneuron dysfunction in epilepsy associated with autism spectrum disorders.
Topics: Aicardi Syndrome; Autism Spectrum Disorder; Cerebral Cortex; Child; Child, Preschool; Epilepsies, My | 2016 |
The epileptic hypothesis: developmentally related arguments based on animal models.
Topics: Age Factors; Animals; Brain; Child, Preschool; Cognition Disorders; Developmental Disabilities; Dise | 2009 |
Vigabatrin in the management of generalized seizures in children.
Topics: Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Electroencephalography; Epileps | 1995 |
[Vigabatrin and lamotrigin: experiences with 2 new anticonvulsants in the Swiss epilepsy clinic].
Topics: 4-Aminobutyrate Transaminase; Adult; Anticonvulsants; Child; Drug Therapy, Combination; Epilepsies, | 1995 |
Treatment of infantile spasms.
Topics: 4-Aminobutyrate Transaminase; Adrenocorticotropic Hormone; Anticonvulsants; Benzodiazepines; gamma-A | 1994 |
Vigabatrin in newly diagnosed infantile spasms.
Topics: Anticonvulsants; gamma-Aminobutyric Acid; Humans; Infant; Infant, Newborn; Spasms, Infantile; Treatm | 1994 |
[The importance of vitamin B 6 for development of the infant. Human medical and animal experiment studies].
Topics: Animals; Central Nervous System; Central Nervous System Diseases; Dopamine; Female; gamma-Aminobutyr | 1996 |
Vigabatrin in the treatment of infantile spasms in tuberous sclerosis: literature review.
Topics: Anticonvulsants; gamma-Aminobutyric Acid; Humans; Infant; Spasms, Infantile; Tuberous Sclerosis; Vig | 1999 |
Use of new antiepileptic drugs in the treatment of childhood epilepsy.
Topics: Acetates; Adult; Age Factors; Amines; Anticonvulsants; Child; Clinical Trials as Topic; Cyclohexanec | 1999 |
Vigabatrin.
Topics: 4-Aminobutyrate Transaminase; Anticonvulsants; Brain Chemistry; Clinical Trials as Topic; Cognition; | 1999 |
Pathophysiology of epilepsy.
Topics: Adult; Animals; Anticonvulsants; Autoimmune Diseases; Calcium; Catecholamines; Cell Movement; Child; | 2000 |
8 trials available for gamma-aminobutyric acid and Cryptogenic Infantile Spasms
| Article | Year |
|---|---|
Vigabatrin as initial therapy for infantile spasms: a European retrospective survey. Sabril IS Investigator and Peer Review Groups.
Topics: Age of Onset; Anticonvulsants; Child, Preschool; Dose-Response Relationship, Drug; Drug Administrati | 1996 |
Randomized trial comparing vigabatrin and hydrocortisone in infantile spasms due to tuberous sclerosis.
Topics: Anticonvulsants; Female; gamma-Aminobutyric Acid; Humans; Hydrocortisone; Infant; Infant, Newborn; M | 1997 |
Vigabatrin as first line therapy in infantile spasms: review of seven patients.
Topics: Anticonvulsants; Female; gamma-Aminobutyric Acid; Humans; Infant; Male; Spasms, Infantile; Treatment | 1997 |
Vigabatrin as add-on therapy in children and adolescents with refractory epilepsy: an open trial.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Drug Resistance; Drug Therapy, Combinat | 1997 |
Vigabatrin versus ACTH as first-line treatment for infantile spasms: a randomized, prospective study.
Topics: Adrenocorticotropic Hormone; Age of Onset; Anticonvulsants; Delayed-Action Preparations; Drug Admini | 1997 |
Vigabatrin as a first-line drug in West syndrome: clinical and electroencephalographic outcome.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Cerebral Cortex; Child, Preschool; Developmental Disab | 1998 |
Long-term follow-up study of vigabatrin in pretreated children with West syndrome.
Topics: Adrenocorticotropic Hormone; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Child, Preschool | 1998 |
Treatment of infantile spasms: results of a population-based study with vigabatrin as the first drug for spasms.
Topics: 4-Aminobutyrate Transaminase; Adrenocorticotropic Hormone; Anticonvulsants; Brain Diseases; Child; C | 1999 |
35 other studies available for gamma-aminobutyric acid and Cryptogenic Infantile Spasms
| Article | Year |
|---|---|
Cell-Selective Adeno-Associated Virus-Mediated
Topics: Animals; Dependovirus; Disease Models, Animal; Epilepsies, Myoclonic; Epileptic Syndromes; gamma-Ami | 2022 |
Metabolomic signature of the Dravet syndrome: A genetic mouse model study.
Topics: Animals; Bile Acids and Salts; Disease Models, Animal; Epilepsies, Myoclonic; Epileptic Syndromes; g | 2021 |
Rapid whole-genome sequencing identifies a novel
Topics: Brain; Developmental Disabilities; Electroencephalography; gamma-Aminobutyric Acid; Genome; High-Thr | 2017 |
[Electrophysiology of intractable childhood epilepsy].
Topics: Brain; Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; gamma-Aminobutyric Acid; | 2014 |
Population pharmacokinetics analysis of vigabatrin in adults and children with epilepsy and children with infantile spasms.
Topics: Adult; Body Weight; Child; Child, Preschool; Enzyme Inhibitors; Epilepsy; Female; gamma-Aminobutyric | 2014 |
Aberrant mTOR signaling and disrupted autophagy: The missing link in potential vigabatrin-associated ocular toxicity?
Topics: Anticonvulsants; Autophagy; Evoked Potentials, Visual; gamma-Aminobutyric Acid; Humans; Infant; Infa | 2017 |
GABA(A) receptor properties in catastrophic infantile epilepsy.
Topics: 5-alpha-Dihydroprogesterone; Animals; Biophysics; Brain; Cell Membrane; Dose-Response Relationship, | 2008 |
West syndrome caused by ST3Gal-III deficiency.
Topics: Adolescent; Age of Onset; Animals; Anticonvulsants; beta-Galactoside alpha-2,3-Sialyltransferase; Ch | 2013 |
Trial of amino-oxyacetic acid, an anticonvulsant.
Topics: Amino Acids; Anticonvulsants; Brain; Child; Epilepsy; Epilepsy, Tonic-Clonic; gamma-Aminobutyric Aci | 1963 |
A successful treatment with pyridoxal phosphate for West syndrome in hypophosphatasia.
Topics: Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Electroencephalography; Fata | 2004 |
Cerebrospinal fluid GABA levels in children with infantile spasms.
Topics: Adrenocorticotropic Hormone; Female; gamma-Aminobutyric Acid; Humans; Infant; Lumbosacral Region; Ma | 1984 |
Vigabatrin monotherapy in resistant neonatal seizures.
Topics: Agenesis of Corpus Callosum; Anticonvulsants; Atrophy; Brain; Cerebral Cortex; Dose-Response Relatio | 1995 |
'A simple, effective and well-tolerated treatment regime for West Syndrome'.
Topics: Anticonvulsants; Female; Follow-Up Studies; gamma-Aminobutyric Acid; Humans; Infant; Male; Spasms, I | 1995 |
The treatment of infantile spasms by paediatric neurologists in the UK and Ireland.
Topics: Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Anticonvulsants; gamma-Aminobutyric Acid; Hum | 1996 |
[Vigabatrin in the treatment of infantile spasms].
Topics: Adrenocorticotropic Hormone; Anticonvulsants; gamma-Aminobutyric Acid; Humans; Infant; Male; Spasms, | 1995 |
[Treatment of refractory infantile epilepsy with vigabatrin in a series of 55 patients].
Topics: Adolescent; Anticonvulsants; Brain; Child; Child, Preschool; Epilepsy; Female; gamma-Aminobutyric Ac | 1996 |
Pyridoxine--responsive West syndrome and gamma-aminobutyric acid.
Topics: gamma-Aminobutyric Acid; Humans; Infant; Male; Pyridoxine; Spasms, Infantile | 1997 |
Impairment of neocortical ontogenetic program leading to severe infantile encephalopathy with burst suppression.
Topics: Brain Damage, Chronic; Brain Mapping; Cerebral Cortex; Delta Rhythm; Electroencephalography; Epileps | 1996 |
[West's syndrome in patients with cerebral paralysis and periventricular leukomalacia: a good response to treatment].
Topics: Anticonvulsants; Atrophy; Cerebral Palsy; Cerebral Ventricles; Child; Child, Preschool; Female; gamm | 1997 |
[Monotherapy with vigabatrin in the treatment of West's syndrome].
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Female; gamma-Aminobutyric Acid; Humans; Infant; Male; | 1997 |
Falsely elevated urinary ethanolamine levels due to vigabatrin.
Topics: Anticonvulsants; Child, Preschool; Developmental Disabilities; Ethanolamine; Female; gamma-Aminobuty | 1998 |
[Treatment of infantile spasms with vigabatrin as first-line therapy and in monotherapy: apropos of 70 infants].
Topics: Anti-Inflammatory Agents; Anticonvulsants; Drug Administration Schedule; Female; gamma-Aminobutyric | 1998 |
Infantile spasms and vigabatrin. Study will compare effects of drugs.
Topics: Anticonvulsants; gamma-Aminobutyric Acid; Humans; Infant; Publishing; Spasms, Infantile; Vigabatrin | 1999 |
Infantile spasms and vigabatrin. Visual field defects may be permanent.
Topics: Adult; Anticonvulsants; Child; gamma-Aminobutyric Acid; Humans; Infant; Practice Guidelines as Topic | 1999 |
Vigabatrin in the treatment of infantile spasms.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Drug Resistance; Electroencephalography; Female; gamma | 1999 |
Vigabatrin: new indication. An advance in infantile spasms.
Topics: Anticonvulsants; Child; Child, Preschool; Clinical Trials as Topic; Drug Evaluation; France; gamma-A | 1998 |
Is the devil we know the lesser of two evils? Vigabatrin and visual fields.
Topics: Adrenocorticotropic Hormone; gamma-Aminobutyric Acid; Humans; Spasms, Infantile; Vigabatrin; Visual | 1999 |
ACTH versus vigabatrin therapy in infantile spasms: a retrospective study.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Female; gamma-Aminobutyric Acid; Humans; Infant; Male; | 1999 |
[The usefulness of statistical tests in publications].
Topics: 4-Aminobutyrate Transaminase; Anti-Inflammatory Agents; Anticonvulsants; Chi-Square Distribution; En | 1999 |
Development of GABAergic neurons and their transporter in human temporal cortex.
Topics: Adolescent; Adult; Aged; Carrier Proteins; Child; Child, Preschool; Female; GABA Plasma Membrane Tra | 2001 |
Photically induced epilepsy in Papio papio as a model for drug studies.
Topics: Acetylcholine; Animals; Carbamazepine; Clonazepam; Diazepam; Disease Models, Animal; Dopamine; Dose- | 1975 |
The concentrations of GABA, 5-HIAA and HVA in the cerebrospinal fluid of children with infantile spasms and the effects of ACTH treatment.
Topics: Adolescent; Adrenocorticotropic Hormone; Analysis of Variance; Child; Child, Preschool; gamma-Aminob | 1992 |
Low cerebrospinal fluid concentration of free gamma-aminobutyric acid in startle disease.
Topics: Clonazepam; Electroencephalography; Female; gamma-Aminobutyric Acid; Humans; Infant, Newborn; Phenob | 1992 |
Low level of GABA in CSF in vitamin B6-dependent seizures.
Topics: Electroencephalography; gamma-Aminobutyric Acid; Humans; Infant; Male; Pyridoxine; Spasms, Infantile | 1991 |
[Pyridoxine-dependent seizures. Remarks on clinical variability and pathogenesis].
Topics: Anticonvulsants; Electroencephalography; Follow-Up Studies; gamma-Aminobutyric Acid; Humans; Infant; | 1990 |