gamma-aminobutyric acid has been researched along with Craniofacial Pain in 32 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Orofacial capsaicin and formalin tests were employed in male Wistar rats to assess the influence of pregabalin (or vehicle) pretreatment in acute pain models, and the results from these experiments were analyzed by one-way analysis of variance (ANOVA) followed by Newman Keuls post-hoc test." | 7.80 | Pregabalin reduces acute inflammatory and persistent pain associated with nerve injury and cancer in rat models of orofacial pain. ( Chichorro, JG; Hummig, W; Kopruszinski, CM, 2014) |
| "To assess the analgesic effect of pregabalin in orofacial models of acute inflammatory pain and of persistent pain associated with nerve injury and cancer, and so determine its effectiveness in controlling orofacial pains having different underlying mechanisms." | 7.80 | Pregabalin reduces acute inflammatory and persistent pain associated with nerve injury and cancer in rat models of orofacial pain. ( Chichorro, JG; Hummig, W; Kopruszinski, CM, 2014) |
| "Pregabalin produced a marked antinociceptive effect in rat models of facial inflammatory pain as well as in facial neuropathic and cancer pain models, suggesting that it may represent an important agent for the clinical control of orofacial pain." | 7.80 | Pregabalin reduces acute inflammatory and persistent pain associated with nerve injury and cancer in rat models of orofacial pain. ( Chichorro, JG; Hummig, W; Kopruszinski, CM, 2014) |
| "To evaluate the nature of the antinociceptive interaction of systemic administration of a combination of the anticonvulsant gabapentin with the antidepressant nortriptyline, by isobolographic analysis in the formalin orofacial pain test of mice." | 7.79 | Isobolographic analysis in mice of the interaction of gabapentin and nortriptyline in relieving orofacial pain. ( Miranda, HF; Noriega, V; Prieto, JC; Zanetta, P, 2013) |
| "The aim of this study was to evaluate the effect of topical treatment with pregabalin and diclofenac on neuropathic orofacial pain induced by infraorbital nerve injury in the rat." | 7.78 | Topical pregabalin and diclofenac for the treatment of neuropathic orofacial pain in rats. ( Benoliel, R; Eliav, E; Heir, G; Khan, J; Markman, S; Noma, N; Patel, J; Plaza-Villegas, F, 2012) |
| "Topical treatment with pregabalin or diclofenac can reduce neuropathic orofacial pain induced by nerve injury." | 7.78 | Topical pregabalin and diclofenac for the treatment of neuropathic orofacial pain in rats. ( Benoliel, R; Eliav, E; Heir, G; Khan, J; Markman, S; Noma, N; Patel, J; Plaza-Villegas, F, 2012) |
| "This prospective, open-label study aimed to evaluate the efficacy of pregabalin treatment in patients suffering from trigeminal neuralgia with and without concomitant facial pain." | 7.74 | Efficacy of pregabalin in the treatment of trigeminal neuralgia. ( Diener, HC; Katsarava, Z; Maschke, M; Obermann, M; Sensen, K; Yoon, MS, 2008) |
| "Gabapentin was 1." | 5.39 | Isobolographic analysis in mice of the interaction of gabapentin and nortriptyline in relieving orofacial pain. ( Miranda, HF; Noriega, V; Prieto, JC; Zanetta, P, 2013) |
| "Patients without concomitant facial pain showed better response rates (32 of 39, 82%) compared with patients with concomitant chronic facial pain (7 of 14, 50%, P = 0." | 5.35 | Efficacy of pregabalin in the treatment of trigeminal neuralgia. ( Diener, HC; Katsarava, Z; Maschke, M; Obermann, M; Sensen, K; Yoon, MS, 2008) |
| "Orofacial capsaicin and formalin tests were employed in male Wistar rats to assess the influence of pregabalin (or vehicle) pretreatment in acute pain models, and the results from these experiments were analyzed by one-way analysis of variance (ANOVA) followed by Newman Keuls post-hoc test." | 3.80 | Pregabalin reduces acute inflammatory and persistent pain associated with nerve injury and cancer in rat models of orofacial pain. ( Chichorro, JG; Hummig, W; Kopruszinski, CM, 2014) |
| "To assess the analgesic effect of pregabalin in orofacial models of acute inflammatory pain and of persistent pain associated with nerve injury and cancer, and so determine its effectiveness in controlling orofacial pains having different underlying mechanisms." | 3.80 | Pregabalin reduces acute inflammatory and persistent pain associated with nerve injury and cancer in rat models of orofacial pain. ( Chichorro, JG; Hummig, W; Kopruszinski, CM, 2014) |
| "Pregabalin produced a marked antinociceptive effect in rat models of facial inflammatory pain as well as in facial neuropathic and cancer pain models, suggesting that it may represent an important agent for the clinical control of orofacial pain." | 3.80 | Pregabalin reduces acute inflammatory and persistent pain associated with nerve injury and cancer in rat models of orofacial pain. ( Chichorro, JG; Hummig, W; Kopruszinski, CM, 2014) |
| "To evaluate the nature of the antinociceptive interaction of systemic administration of a combination of the anticonvulsant gabapentin with the antidepressant nortriptyline, by isobolographic analysis in the formalin orofacial pain test of mice." | 3.79 | Isobolographic analysis in mice of the interaction of gabapentin and nortriptyline in relieving orofacial pain. ( Miranda, HF; Noriega, V; Prieto, JC; Zanetta, P, 2013) |
| "The aim of this study was to evaluate the effect of topical treatment with pregabalin and diclofenac on neuropathic orofacial pain induced by infraorbital nerve injury in the rat." | 3.78 | Topical pregabalin and diclofenac for the treatment of neuropathic orofacial pain in rats. ( Benoliel, R; Eliav, E; Heir, G; Khan, J; Markman, S; Noma, N; Patel, J; Plaza-Villegas, F, 2012) |
| "Topical treatment with pregabalin or diclofenac can reduce neuropathic orofacial pain induced by nerve injury." | 3.78 | Topical pregabalin and diclofenac for the treatment of neuropathic orofacial pain in rats. ( Benoliel, R; Eliav, E; Heir, G; Khan, J; Markman, S; Noma, N; Patel, J; Plaza-Villegas, F, 2012) |
| "This prospective, open-label study aimed to evaluate the efficacy of pregabalin treatment in patients suffering from trigeminal neuralgia with and without concomitant facial pain." | 3.74 | Efficacy of pregabalin in the treatment of trigeminal neuralgia. ( Diener, HC; Katsarava, Z; Maschke, M; Obermann, M; Sensen, K; Yoon, MS, 2008) |
| "Chronic orofacial pain can greatly improve following treatment of the underlying insomnia, and therefore, re-evaluation of COFP is advised after 1 month of treatment." | 2.55 | An update of management of insomnia in patients with chronic orofacial pain. ( Almoznino, G; Benoliel, R; Haviv, Y; Sharav, Y, 2017) |
| "Behavioral therapies for insomnia include the following: sleep hygiene, cognitive behavioral therapy for insomnia, multicomponent behavioral therapy or brief behavioral therapy for insomnia, relaxation strategies, stimulus control, and sleep restriction." | 2.55 | An update of management of insomnia in patients with chronic orofacial pain. ( Almoznino, G; Benoliel, R; Haviv, Y; Sharav, Y, 2017) |
| "Trigeminal neuralgia is a unique neuropathic pain disorder with a specific therapy." | 2.42 | Management issues of neuropathic trigeminal pain from a medical perspective. ( Watson, CP, 2004) |
| "In this study orofacial pain was induced by injecting male rats with the human VZV." | 1.72 | Neurexin 3α in the Central Amygdala has a Role in Orofacial Varicella Zoster Pain. ( Hornung, R; Kinchington, PR; Kramer, PR; Umorin, M, 2022) |
| "Gabapentin is a good alternative therapeutic option to anesthetic blockade." | 1.43 | Auriculotemporal Neuralgia: Eight New Cases Report. ( Cuadrado, ML; de la Cruz, C; Garcia-Ptacek, S; Guerrero, AL; Porta-Etessam, J; Ruiz, M, 2016) |
| "Thirty patients with atypical facial pain were treated with noophen." | 1.42 | [Emotional and personality disorders in atypical facial pain]. ( Maximova, MY; Suanova, ET, 2015) |
| " Time-course data for the dose-response effects were analyzed using two-way analysis of variance and the posthoc Tukey-Kramer multiple-comparison test." | 1.40 | Antinociceptive effects of mirtazapine, pregabalin, and gabapentin after chronic constriction injury of the infraorbital nerve in rats. ( Hashimoto, R; Hosokawa, K; Mashimo, T; Nakae, A; Nakai, K, 2014) |
| "Gabapentin was 1." | 1.39 | Isobolographic analysis in mice of the interaction of gabapentin and nortriptyline in relieving orofacial pain. ( Miranda, HF; Noriega, V; Prieto, JC; Zanetta, P, 2013) |
| "Neuropathic and/or neuralgic facial pain occurred in 50% (n = 7)." | 1.35 | The trigeminal trophic syndrome: an unusual cause of face pain, dysaesthesias, anaesthesia and skin/soft tissue lesions. ( Garza, I, 2008) |
| "This report describes a case of chronic facial pain in a patient with this condition which was confirmed radiologically." | 1.35 | Diagnosis of osteochondroma of the mandibular condyle in atypical facial pain: a case report. ( Aghabeigi, B; Nasr, IH, 2008) |
| "Gabapentin is a useful agent for the relief of trigeminal neuralgia and orofacial phantom pain." | 1.35 | [Interaction between gabapentin and D-serin in the formalin orofacial test]. ( González, LE; Hernández, L; Quiñónez, B; Silva, E, 2009) |
| "Patients without concomitant facial pain showed better response rates (32 of 39, 82%) compared with patients with concomitant chronic facial pain (7 of 14, 50%, P = 0." | 1.35 | Efficacy of pregabalin in the treatment of trigeminal neuralgia. ( Diener, HC; Katsarava, Z; Maschke, M; Obermann, M; Sensen, K; Yoon, MS, 2008) |
| "None of the patients reported any facial pain before surgery or trauma." | 1.31 | Facial pain following sinonasal surgery or facial trauma. ( Jones, NS; Khan, OA; Majumdar, S, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (3.13) | 18.2507 |
| 2000's | 9 (28.13) | 29.6817 |
| 2010's | 20 (62.50) | 24.3611 |
| 2020's | 2 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Kramer, PR | 1 |
| Umorin, M | 1 |
| Hornung, R | 1 |
| Kinchington, PR | 1 |
| Cseh, EK | 1 |
| Veres, G | 1 |
| Körtési, T | 1 |
| Polyák, H | 1 |
| Nánási, N | 1 |
| Tajti, J | 1 |
| Párdutz, Á | 1 |
| Klivényi, P | 1 |
| Vécsei, L | 1 |
| Zádori, D | 1 |
| de Matos, NMP | 1 |
| Hock, A | 1 |
| Wyss, M | 1 |
| Ettlin, DA | 1 |
| Brügger, M | 1 |
| Kumar, N | 1 |
| Cherkas, PS | 1 |
| Varathan, V | 1 |
| Miyamoto, M | 1 |
| Chiang, CY | 2 |
| Dostrovsky, JO | 2 |
| Sessle, BJ | 2 |
| Coderre, TJ | 1 |
| Haribabu, PK | 1 |
| Eliav, E | 2 |
| Heir, GM | 1 |
| Marchiori, ÉC | 1 |
| Barber, JS | 1 |
| Williams, WB | 1 |
| Bui, PQ | 1 |
| O'Ryan, FS | 1 |
| Yin, H | 1 |
| Cho, DH | 2 |
| Park, SJ | 2 |
| Han, SK | 2 |
| Miranda, HF | 1 |
| Noriega, V | 1 |
| Zanetta, P | 1 |
| Prieto, JC | 1 |
| Nakai, K | 1 |
| Nakae, A | 1 |
| Hashimoto, R | 1 |
| Mashimo, T | 1 |
| Hosokawa, K | 1 |
| Kothbauer, KF | 1 |
| Hummig, W | 1 |
| Kopruszinski, CM | 1 |
| Chichorro, JG | 2 |
| Nguyen, HT | 1 |
| Bhattarai, JP | 1 |
| Lee, JC | 1 |
| Alwanni, N | 1 |
| Altay, MA | 1 |
| Baur, DA | 1 |
| Quereshy, FA | 1 |
| Ruiz, M | 1 |
| Porta-Etessam, J | 2 |
| Garcia-Ptacek, S | 1 |
| de la Cruz, C | 1 |
| Cuadrado, ML | 2 |
| Guerrero, AL | 1 |
| Maximova, MY | 1 |
| Suanova, ET | 1 |
| Almoznino, G | 1 |
| Haviv, Y | 1 |
| Sharav, Y | 1 |
| Benoliel, R | 2 |
| Jacob, S | 1 |
| Saha, A | 1 |
| Rajabally, Y | 1 |
| Garza, I | 1 |
| Nasr, IH | 1 |
| Aghabeigi, B | 1 |
| Galán, L | 1 |
| Sampedro, A | 1 |
| Valencia, C | 1 |
| Quiñónez, B | 1 |
| Silva, E | 1 |
| González, LE | 1 |
| Hernández, L | 1 |
| Martin, WJ | 1 |
| Forouzanfar, T | 1 |
| Forssell, H | 1 |
| Teerijoki-Oksa, T | 1 |
| Kotiranta, U | 1 |
| Kantola, R | 1 |
| Bäck, M | 1 |
| Vuorjoki-Ranta, TR | 1 |
| Siponen, M | 1 |
| Leino, A | 1 |
| Puukka, P | 1 |
| Estlander, AM | 1 |
| Plaza-Villegas, F | 1 |
| Heir, G | 1 |
| Markman, S | 1 |
| Khan, J | 1 |
| Noma, N | 1 |
| Patel, J | 1 |
| Nones, CF | 1 |
| Reis, RC | 1 |
| Jesus, CH | 1 |
| Veronez, DA | 1 |
| Cunha, JM | 1 |
| Cao, Y | 1 |
| Wang, H | 1 |
| Hänsel, A | 1 |
| Watson, CP | 1 |
| Kimos, P | 1 |
| Biggs, C | 1 |
| Mah, J | 1 |
| Heo, G | 1 |
| Rashiq, S | 1 |
| Thie, NM | 1 |
| Major, PW | 1 |
| Obermann, M | 1 |
| Yoon, MS | 1 |
| Sensen, K | 1 |
| Maschke, M | 1 |
| Diener, HC | 1 |
| Katsarava, Z | 1 |
| Rosner, H | 1 |
| Rubin, L | 1 |
| Kestenbaum, A | 1 |
| Khan, OA | 1 |
| Majumdar, S | 1 |
| Jones, NS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Erenumab as a Therapeutic Approach for the Management of Painful Chronic Temporomandibular Disorders (TMD)[NCT05162027] | Phase 2 | 5 participants (Actual) | Interventional | 2022-04-01 | Terminated (stopped due to Low enrollment rate) | ||
| Prospective, Cross Over Gabapentin vs Amitriptyline Study on Patients Suffering From Masticatory Muscle Pain[NCT02339662] | Phase 4 | 50 participants (Anticipated) | Interventional | 2015-02-28 | Recruiting | ||
| Persistent Postoperative Pain Incidence With Long Term Perioperative Gabapentin Used[NCT02693821] | Phase 4 | 122 participants (Actual) | Interventional | 2015-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for gamma-aminobutyric acid and Craniofacial Pain
| Article | Year |
|---|---|
An update of management of insomnia in patients with chronic orofacial pain.
Topics: Amines; Anticonvulsants; Antidepressive Agents; Benzodiazepines; Chronic Pain; Cognitive Behavioral | 2017 |
The efficacy of anticonvulsants on orofacial pain: a systematic review.
Topics: Amines; Anticonvulsants; Burning Mouth Syndrome; Carbamazepine; Clonazepam; Cyclohexanecarboxylic Ac | 2011 |
Management issues of neuropathic trigeminal pain from a medical perspective.
Topics: Amines; Analgesics, Non-Narcotic; Anticonvulsants; Antidepressive Agents; Baclofen; Carbamazepine; C | 2004 |
2 trials available for gamma-aminobutyric acid and Craniofacial Pain
| Article | Year |
|---|---|
Analgesic action of gabapentin on chronic pain in the masticatory muscles: a randomized controlled trial.
Topics: Adolescent; Adult; Amines; Analgesics; Anticonvulsants; Chronic Disease; Cyclohexanecarboxylic Acids | 2007 |
Analgesic action of gabapentin on chronic pain in the masticatory muscles: a randomized controlled trial.
Topics: Adolescent; Adult; Amines; Analgesics; Anticonvulsants; Chronic Disease; Cyclohexanecarboxylic Acids | 2007 |
Analgesic action of gabapentin on chronic pain in the masticatory muscles: a randomized controlled trial.
Topics: Adolescent; Adult; Amines; Analgesics; Anticonvulsants; Chronic Disease; Cyclohexanecarboxylic Acids | 2007 |
Analgesic action of gabapentin on chronic pain in the masticatory muscles: a randomized controlled trial.
Topics: Adolescent; Adult; Amines; Analgesics; Anticonvulsants; Chronic Disease; Cyclohexanecarboxylic Acids | 2007 |
Gabapentin adjunctive therapy in neuropathic pain states.
Topics: Acetates; Adult; Aged; Amines; Analgesics; Cyclohexanecarboxylic Acids; Facial Pain; Female; Gabapen | 1996 |
27 other studies available for gamma-aminobutyric acid and Craniofacial Pain
| Article | Year |
|---|---|
Neurexin 3α in the Central Amygdala has a Role in Orofacial Varicella Zoster Pain.
Topics: Animals; Central Amygdaloid Nucleus; Chickenpox; Facial Pain; GABAergic Neurons; gamma-Aminobutyric | 2022 |
Neurotransmitter and tryptophan metabolite concentration changes in the complete Freund's adjuvant model of orofacial pain.
Topics: Animals; Facial Pain; Freund's Adjuvant; gamma-Aminobutyric Acid; Glutamic Acid; Kynurenic Acid; Mal | 2020 |
Neurochemical dynamics of acute orofacial pain in the human trigeminal brainstem nuclear complex.
Topics: Adult; Aspartic Acid; Dipeptides; Facial Pain; Female; gamma-Aminobutyric Acid; Humans; Male; Middle | 2017 |
Systemic pregabalin attenuates facial hypersensitivity and noxious stimulus-evoked release of glutamate in medullary dorsal horn in a rodent model of trigeminal neuropathic pain.
Topics: Analgesics; Analysis of Variance; Animals; Chromatography, High Pressure Liquid; Data Interpretation | 2013 |
Topical medications for the effective management of neuropathic orofacial pain.
Topics: Administration, Topical; Amines; Analgesics, Non-Narcotic; Anesthetics, Local; Anti-Inflammatory Age | 2013 |
Neuropathic pain following sagittal split ramus osteotomy of the mandible: prevalence, risk factors, and clinical course.
Topics: Adult; Age Factors; Amines; Anticonvulsants; Antidepressive Agents, Tricyclic; Cohort Studies; Cyclo | 2013 |
GABA-mimetic actions of Withania somnifera on substantia gelatinosa neurons of the trigeminal subnucleus caudalis in mice.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cells, Cultured; Chloride Channels; Dose-Response Rel | 2013 |
Isobolographic analysis in mice of the interaction of gabapentin and nortriptyline in relieving orofacial pain.
Topics: Amines; Animals; Anticonvulsants; Antidepressive Agents; Cyclohexanecarboxylic Acids; Drug Synergism | 2013 |
Antinociceptive effects of mirtazapine, pregabalin, and gabapentin after chronic constriction injury of the infraorbital nerve in rats.
Topics: Adrenergic alpha-Antagonists; Amines; Analgesics; Animals; Cranial Nerve Injuries; Cyclohexanecarbox | 2014 |
[Facial pain].
Topics: Aged; Analgesics; Facial Pain; gamma-Aminobutyric Acid; Humans; Male; Microvascular Decompression Su | 2014 |
Pregabalin reduces acute inflammatory and persistent pain associated with nerve injury and cancer in rat models of orofacial pain.
Topics: Acute Pain; Analgesics; Animals; Anti-Inflammatory Agents; Capsaicin; Carrageenan; Chronic Pain; Dis | 2014 |
Enhanced GABA action on the substantia gelatinosa neurons of the medullary dorsal horn in the offspring of streptozotocin-injected mice.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes, Gestational; Diabetic Neuropathies; Facial Nerve | 2015 |
First Bite Syndrome After Bilateral Temporomandibular Joint Replacement: Case Report.
Topics: Adult; Amines; Analgesics; Arthroplasty, Replacement; Cyclohexanecarboxylic Acids; Facial Pain; Fema | 2016 |
Auriculotemporal Neuralgia: Eight New Cases Report.
Topics: Adult; Aged; Amines; Analgesics; Cyclohexanecarboxylic Acids; Facial Pain; Female; Gabapentin; gamma | 2016 |
[Emotional and personality disorders in atypical facial pain].
Topics: Adult; Aged; Antidepressive Agents; Anxiety Disorders; Depressive Disorder; Facial Pain; Female; gam | 2015 |
Post-traumatic short-lasting unilateral headache with cranial autonomic symptoms (SUNA).
Topics: Accidents, Traffic; Adult; Amines; Carbamazepine; Conjunctiva; Cyclohexanecarboxylic Acids; Facial P | 2008 |
The trigeminal trophic syndrome: an unusual cause of face pain, dysaesthesias, anaesthesia and skin/soft tissue lesions.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amines; Child; Cyclohexanecarboxylic Acids; Erythema; Fa | 2008 |
Diagnosis of osteochondroma of the mandibular condyle in atypical facial pain: a case report.
Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Facial Pain; Gabapentin; gamma-Aminobutyric Acid; H | 2008 |
Temporal response to bupivacaine bilateral great occipital block in a patient with SUNCT syndrome.
Topics: Aged, 80 and over; Amines; Anesthetics, Local; Anticonvulsants; Bupivacaine; Cyclohexanecarboxylic A | 2010 |
[Interaction between gabapentin and D-serin in the formalin orofacial test].
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Drug Interactions; Facial Pain; Gabapentin | 2009 |
Pain and pain behavior in burning mouth syndrome: a pain diary study.
Topics: Adaptation, Psychological; Analgesics; Analysis of Variance; Anticonvulsants; Antidepressive Agents, | 2012 |
Topical pregabalin and diclofenac for the treatment of neuropathic orofacial pain in rats.
Topics: Administration, Topical; Analysis of Variance; Animals; Diclofenac; Facial Pain; gamma-Aminobutyric | 2012 |
Orofacial sensory changes after streptozotocin-induced diabetes in rats.
Topics: Analgesics; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Facial Pain; gamma-Amin | 2013 |
Pregabalin suppresses nociceptive behavior and central sensitization in a rat trigeminal neuropathic pain model.
Topics: Analgesics; Animals; Behavior, Animal; Cranial Nerve Injuries; Electric Stimulation; Facial Pain; ga | 2013 |
[Neuritis of the maxillary nerve. A 55-year-old housewife].
Topics: Amines; Analgesics; Anti-Inflammatory Agents; Cluster Headache; Cranial Nerve Diseases; Cyclohexanec | 2004 |
Efficacy of pregabalin in the treatment of trigeminal neuralgia.
Topics: Adult; Aged; Aged, 80 and over; Analgesics; Chronic Disease; Dose-Response Relationship, Drug; Facia | 2008 |
Facial pain following sinonasal surgery or facial trauma.
Topics: Acetates; Adult; Aged; Amines; Amitriptyline; Analgesics, Non-Narcotic; Carbamazepine; Cyclohexaneca | 2002 |