gamma-aminobutyric acid has been researched along with Cramp in 9 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "With multiple problems emerging from premature termination in mind, the results suggested an acceptable safety profile and favorable effect of pregabalin in reducing muscle cramps compared to placebo in cirrhotic patients." | 9.51 | Efficacy and Safety of Pregabalin for Muscle Cramps in Liver Cirrhosis: A Double-Blind Randomized Controlled Trial. ( Ahn, S; Choi, K; Hong, YH; Joo, SK; Jung, YJ; Kim, W; Lee, DH; Sohn, SY, 2022) |
| "At a dose of 400mg orally three times a day, gabapentin may be of value in the treatment of the spasticity and painful muscle cramping experienced by patients with multiple sclerosis." | 9.08 | Gabapentin for relief of upper motor neuron symptoms in multiple sclerosis. ( Gruenthal, M; Mueller, ME; Olson, WH; Olson, WL, 1997) |
| "To examine the efficacy of gabapentin in the treatment of spasticity and painful muscle spasms in patients with multiple sclerosis." | 9.08 | Gabapentin for relief of upper motor neuron symptoms in multiple sclerosis. ( Gruenthal, M; Mueller, ME; Olson, WH; Olson, WL, 1997) |
| "Selection and extraction: a MEDLINE/PubMed, English-language literature search from 1966 to the present using quinine, leg cramps, vitamin E, verapamil, muscle relaxants, gabapentin as search terms." | 8.84 | Are there alternatives to the use of quinine to treat nocturnal leg cramps? ( Guay, DR, 2008) |
| "Are there any alternatives to quinine for leg cramps? Data are available supporting the potential efficacy of verapamil, gabapentin, carisoprodol, and orphenadrine in the general population, and vitamin E in the dialysis population." | 8.84 | Are there alternatives to the use of quinine to treat nocturnal leg cramps? ( Guay, DR, 2008) |
| "To review the efficacy and tolerability profiles of quinine in nocturnal and dialysis-associated leg cramps and to examine potential alternative agents." | 8.84 | Are there alternatives to the use of quinine to treat nocturnal leg cramps? ( Guay, DR, 2008) |
| "Quinine, an alkaloid originally isolated from the cinchona tree, has been used for many years to treat/prevent leg cramps." | 8.84 | Are there alternatives to the use of quinine to treat nocturnal leg cramps? ( Guay, DR, 2008) |
| "Muscle cramp is possibly related to peripheral nerve hyperexcitability (PNH), and one of the most debilitating symptoms frequently encountered in patients with liver cirrhosis." | 7.11 | Efficacy and Safety of Pregabalin for Muscle Cramps in Liver Cirrhosis: A Double-Blind Randomized Controlled Trial. ( Ahn, S; Choi, K; Hong, YH; Joo, SK; Jung, YJ; Kim, W; Lee, DH; Sohn, SY, 2022) |
| "With multiple problems emerging from premature termination in mind, the results suggested an acceptable safety profile and favorable effect of pregabalin in reducing muscle cramps compared to placebo in cirrhotic patients." | 5.51 | Efficacy and Safety of Pregabalin for Muscle Cramps in Liver Cirrhosis: A Double-Blind Randomized Controlled Trial. ( Ahn, S; Choi, K; Hong, YH; Joo, SK; Jung, YJ; Kim, W; Lee, DH; Sohn, SY, 2022) |
| " Gabapentin therapy proved to be very satisfactory in relieving muscular cramps with a relatively low dosage (600 mg/day) and without any remarkable side effects." | 5.30 | A case of myokymia-cramp syndrome successfully treated with gabapentin. ( Cardinali, P; Parisi, L; Pierelli, F; Rossi, P; Serrao, M; Tramutoli, R, 1998) |
| "Cramps were mainly nocturnal and also precipitated by walking; a previous treatment with carbamazepine did not improve the symptoms." | 5.30 | A case of myokymia-cramp syndrome successfully treated with gabapentin. ( Cardinali, P; Parisi, L; Pierelli, F; Rossi, P; Serrao, M; Tramutoli, R, 1998) |
| "At a dose of 400mg orally three times a day, gabapentin may be of value in the treatment of the spasticity and painful muscle cramping experienced by patients with multiple sclerosis." | 5.08 | Gabapentin for relief of upper motor neuron symptoms in multiple sclerosis. ( Gruenthal, M; Mueller, ME; Olson, WH; Olson, WL, 1997) |
| "To examine the efficacy of gabapentin in the treatment of spasticity and painful muscle spasms in patients with multiple sclerosis." | 5.08 | Gabapentin for relief of upper motor neuron symptoms in multiple sclerosis. ( Gruenthal, M; Mueller, ME; Olson, WH; Olson, WL, 1997) |
| "Selection and extraction: a MEDLINE/PubMed, English-language literature search from 1966 to the present using quinine, leg cramps, vitamin E, verapamil, muscle relaxants, gabapentin as search terms." | 4.84 | Are there alternatives to the use of quinine to treat nocturnal leg cramps? ( Guay, DR, 2008) |
| "Are there any alternatives to quinine for leg cramps? Data are available supporting the potential efficacy of verapamil, gabapentin, carisoprodol, and orphenadrine in the general population, and vitamin E in the dialysis population." | 4.84 | Are there alternatives to the use of quinine to treat nocturnal leg cramps? ( Guay, DR, 2008) |
| "To review the efficacy and tolerability profiles of quinine in nocturnal and dialysis-associated leg cramps and to examine potential alternative agents." | 4.84 | Are there alternatives to the use of quinine to treat nocturnal leg cramps? ( Guay, DR, 2008) |
| "Quinine, an alkaloid originally isolated from the cinchona tree, has been used for many years to treat/prevent leg cramps." | 4.84 | Are there alternatives to the use of quinine to treat nocturnal leg cramps? ( Guay, DR, 2008) |
| "Muscle cramps associated with PNH respond well to symptomatic treatment, particularly with carbamazepine and gabapentin." | 3.83 | Therapeutic Implications of Peripheral Nerve Hyperexcitability in Muscle Cramping: A Retrospective Review. ( Hobson-Webb, LD; Hurst, RL, 2016) |
| "Muscle cramp is possibly related to peripheral nerve hyperexcitability (PNH), and one of the most debilitating symptoms frequently encountered in patients with liver cirrhosis." | 3.11 | Efficacy and Safety of Pregabalin for Muscle Cramps in Liver Cirrhosis: A Double-Blind Randomized Controlled Trial. ( Ahn, S; Choi, K; Hong, YH; Joo, SK; Jung, YJ; Kim, W; Lee, DH; Sohn, SY, 2022) |
| " Gabapentin therapy proved to be very satisfactory in relieving muscular cramps with a relatively low dosage (600 mg/day) and without any remarkable side effects." | 1.30 | A case of myokymia-cramp syndrome successfully treated with gabapentin. ( Cardinali, P; Parisi, L; Pierelli, F; Rossi, P; Serrao, M; Tramutoli, R, 1998) |
| "Cramps were mainly nocturnal and also precipitated by walking; a previous treatment with carbamazepine did not improve the symptoms." | 1.30 | A case of myokymia-cramp syndrome successfully treated with gabapentin. ( Cardinali, P; Parisi, L; Pierelli, F; Rossi, P; Serrao, M; Tramutoli, R, 1998) |
| "Cramps were quite easily induced by volitional exertion and high-frequency stimulation of the peripheral nerves." | 1.29 | Muscle cramp as the result of impaired GABA function--an electrophysiological and pharmacological observation. ( Matsuoka, H; Mizoguchi, K; Nishimura, Y; Obi, T; Takatsu, M, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Ahn, S | 1 |
| Hong, YH | 1 |
| Lee, DH | 1 |
| Joo, SK | 1 |
| Jung, YJ | 1 |
| Sohn, SY | 1 |
| Choi, K | 1 |
| Kim, W | 1 |
| Beladi Mousavi, SS | 1 |
| Zeraati, A | 1 |
| Moradi, S | 1 |
| Mousavi, MB | 1 |
| Hurst, RL | 1 |
| Hobson-Webb, LD | 1 |
| Heuss, D | 1 |
| Guay, DR | 1 |
| Obi, T | 1 |
| Mizoguchi, K | 1 |
| Matsuoka, H | 1 |
| Takatsu, M | 1 |
| Nishimura, Y | 1 |
| Mueller, ME | 1 |
| Gruenthal, M | 1 |
| Olson, WL | 1 |
| Olson, WH | 1 |
| Serrao, M | 1 |
| Cardinali, P | 1 |
| Rossi, P | 1 |
| Parisi, L | 1 |
| Tramutoli, R | 1 |
| Pierelli, F | 1 |
| Sandyk, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Double-blinded, Placebo-controlled Study Evaluating the Efficacy and Safety of 6-week Treatment of Pregabalin Against Frequent Muscle Cramp in Patients With Liver Cirrhosis[NCT01271660] | Phase 3 | 60 participants (Actual) | Interventional | 2011-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for gamma-aminobutyric acid and Cramp
| Article | Year |
|---|---|
Are there alternatives to the use of quinine to treat nocturnal leg cramps?
Topics: Amines; Calcium Channel Blockers; Carisoprodol; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Amino | 2008 |
The endogenous opioid system in neurological disorders of the basal ganglia.
Topics: Animals; Antipsychotic Agents; Basal Ganglia Diseases; Clonidine; Endorphins; gamma-Aminobutyric Aci | 1985 |
3 trials available for gamma-aminobutyric acid and Cramp
| Article | Year |
|---|---|
Efficacy and Safety of Pregabalin for Muscle Cramps in Liver Cirrhosis: A Double-Blind Randomized Controlled Trial.
Topics: Analgesics; Double-Blind Method; gamma-Aminobutyric Acid; Humans; Liver Cirrhosis; Muscle Cramp; Pre | 2022 |
The effect of gabapentin on muscle cramps during hemodialysis: A double-blind clinical trial.
Topics: Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Double-Blind Method; Female; Gabapentin; gamma | 2015 |
Gabapentin for relief of upper motor neuron symptoms in multiple sclerosis.
Topics: Acetates; Adolescent; Adult; Amines; Anticonvulsants; Cross-Over Studies; Cyclohexanecarboxylic Acid | 1997 |
4 other studies available for gamma-aminobutyric acid and Cramp
| Article | Year |
|---|---|
Therapeutic Implications of Peripheral Nerve Hyperexcitability in Muscle Cramping: A Retrospective Review.
Topics: Amines; Analgesics, Non-Narcotic; Antibodies; Carbamazepine; Cyclohexanecarboxylic Acids; Electric S | 2016 |
[Muscle cramp--what is at the bottom of it? Only a little strained or seriously sick?].
Topics: Age Factors; Aged; Amines; Analgesics, Non-Narcotic; Anticonvulsants; Carbamazepine; Citric Acid; Cy | 2006 |
Muscle cramp as the result of impaired GABA function--an electrophysiological and pharmacological observation.
Topics: Amyotrophic Lateral Sclerosis; Baclofen; Clomipramine; Diazepam; Electric Stimulation; Evoked Potent | 1993 |
A case of myokymia-cramp syndrome successfully treated with gabapentin.
Topics: Acetates; Amines; Cyclohexanecarboxylic Acids; Extremities; Fasciculation; Gabapentin; gamma-Aminobu | 1998 |