gamma-aminobutyric acid has been researched along with Convulsive Generalized Seizure Disorder in 72 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine the efficacy of a new anti-epileptic medication vigabatrin in adults and children with drug-resistant epilepsy." | 7.69 | Vigabatrin use in 72 patients with drug-resistant epilepsy. ( Buchanan, N, 1994) |
| "A retrospective survey was carried out of add-on treatment with lamotrigine (LTG) and vigabatrin (GVG) in 109 children with severe epilepsy, treated between 1987 and 1994, identified from a total population of 300 patients seen annually, in a tertiary referral outpatient clinic in Cardiff, Wales." | 7.69 | A survey of lamotrigine and vigabatrin treatment in children with severe epilepsy. ( Gordon, GS; Schapel, GJ; Wallace, SJ, 1997) |
| "Vigabatrin was most effective in cryptogenic and symptomatic partial seizures (39% and 43%, respectively), and in infantile spasms (25%)." | 6.68 | Vigabatrin as add-on therapy in children and adolescents with refractory epilepsy: an open trial. ( Coppola, G; Pascotto, A; Terraciano, AM, 1997) |
| "Vigabatrin has a definite role to play in the management of persons with intractable complex partial seizures where standard anti-epileptic therapy has failed to achieve control." | 5.29 | Vigabatrin use in 72 patients with drug-resistant epilepsy. ( Buchanan, N, 1994) |
| "Rare inherited missense variants in SLC32A1, the gene that encodes the vesicular gamma-aminobutyric acid (GABA) transporter, have recently been shown to cause genetic epilepsy with febrile seizures plus." | 4.12 | De Novo Missense Variants in SLC32A1 Cause a Developmental and Epileptic Encephalopathy Due to Impaired GABAergic Neurotransmission. ( Abou Jamra, R; Bilan, F; Brose, N; Bupp, C; Ganapathi, M; Henderson, LB; Le Guyader, G; Lemke, JR; Pereira, EM; Platzer, K; Sticht, H; Taschenberger, H; Wojcik, SM, 2022) |
| "Recurrent seizures (RS) were induced by flurothyl inhalation in immature rats." | 3.96 | Recurrent seizures cause immature brain injury and changes in GABA a receptor α1 and γ2 subunits. ( Feng, J; Hu, XY; Shi, XY; Tang, JH; Wan, Y; Xi, XJ; Zhang, BB; Zhou, C, 2020) |
| "To determine the efficacy of a new anti-epileptic medication vigabatrin in adults and children with drug-resistant epilepsy." | 3.69 | Vigabatrin use in 72 patients with drug-resistant epilepsy. ( Buchanan, N, 1994) |
| "A retrospective survey was carried out of add-on treatment with lamotrigine (LTG) and vigabatrin (GVG) in 109 children with severe epilepsy, treated between 1987 and 1994, identified from a total population of 300 patients seen annually, in a tertiary referral outpatient clinic in Cardiff, Wales." | 3.69 | A survey of lamotrigine and vigabatrin treatment in children with severe epilepsy. ( Gordon, GS; Schapel, GJ; Wallace, SJ, 1997) |
| "The primary goal of treatment for seizure clusters is cessation of the cluster to avoid progression to more severe conditions, such as prolonged seizures and status epilepticus." | 2.82 | Rescue therapies for seizure clusters: Pharmacology and target of treatments. ( Detyniecki, K; Gidal, B, 2022) |
| "Gabapentin at a dosage of 1200 mg/d is safe and effective in treatment of epilepsy." | 2.71 | [Curative effect of gabapentin on refractory epilepsy]. ( Ding, MP; Hong, Z; Lü, CZ; Ma, GY; Pan, YF; Pan, YZ; Wang, DS; Wang, DX; Xiao, B; Zhao, QC; Zhu, GX, 2005) |
| "Vigabatrin appears to be a reasonable choice for single-drug therapy in the treatment of certain types of seizures." | 2.68 | Newer antiepileptic drugs as monotherapy: data on vigabatrin. ( Fisher, R; Kälviäinen, R; Regesta, G; Tanganelli, P, 1996) |
| "Vigabatrin therapy was ineffective in the four children with tuberous sclerosis." | 2.68 | Vigabatrin in childhood epilepsy: comparable efficacy for generalized and partial seizures. ( Buckley, D; Hobbs, GR; Penney, S; Sheth, RD, 1996) |
| "Gabapentin was well tolerated by patients in both dosage groups, and no patients exited the study due to adverse events, despite rapid initiation of full dose within 24 hours." | 2.68 | Gabapentin monotherapy: I. An 8-day, double-blind, dose-controlled, multicenter study in hospitalized patients with refractory complex partial or secondarily generalized seizures. The US Gabapentin Study Group 88/89. ( Bergey, GK; Blume, WT; Crockatt, JG; Garofalo, E; LaMoreaux, L; Leiderman, DB; Morrell, MJ; Morris, HH; Penovich, PE; Pierce, M; Rosenfeld, W, 1997) |
| " Gabapentin was well tolerated by patients in both dosage groups, and no patients exited the study due to adverse events, despite rapid initiation of full dose within 24 hours." | 2.68 | Gabapentin monotherapy: I. An 8-day, double-blind, dose-controlled, multicenter study in hospitalized patients with refractory complex partial or secondarily generalized seizures. The US Gabapentin Study Group 88/89. ( Bergey, GK; Blume, WT; Crockatt, JG; Garofalo, E; LaMoreaux, L; Leiderman, DB; Morrell, MJ; Morris, HH; Penovich, PE; Pierce, M; Rosenfeld, W, 1997) |
| " Results of outcome measures, including time to exit, completion rate, and mean time on monotherapy, showed no significant differences among dosage groups." | 2.68 | Gabapentin monotherapy: II. A 26-week, double-blind, dose-controlled, multicenter study of conversion from polytherapy in outpatients with refractory complex partial or secondarily generalized seizures. The US Gabapentin Study Group 82/83. ( Abou-Khalil, B; Beydoun, A; Cantrell, D; Fischer, J; Garofalo, E; Greiner, M; Harden, C; Hayes, A; Labar, DR; Pierce, M; Ramsay, RE; Sackellares, JC; Uthman, BM, 1997) |
| "Vigabatrin was most effective in cryptogenic and symptomatic partial seizures (39% and 43%, respectively), and in infantile spasms (25%)." | 2.68 | Vigabatrin as add-on therapy in children and adolescents with refractory epilepsy: an open trial. ( Coppola, G; Pascotto, A; Terraciano, AM, 1997) |
| " Vigabatrin mean dosage during phase 3 was 63." | 2.68 | Vigabatrin in refractory childhood epilepsy. The Brazilian Multicenter Study. ( Chisté, MA; da Costa, JC; Diament, A; Gherpelli, JL; Guerreiro, CA; Guerreiro, MM; Manreza, ML; Nunes, ML; Palmini, A; Pedroso, F; Reed, UC; Rotta, NT; Silva, EA; Vega-Gutiérrez, L; Vizioli, J, 1997) |
| "Epilepsy is a common neurological condition with a worldwide prevalence of around 1%." | 2.55 | Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data. ( Marson, AG; Nevitt, SJ; Sudell, M; Tudur Smith, C; Weston, J, 2017) |
| "Epilepsy is a common neurological condition with a worldwide prevalence of around 1%." | 2.55 | Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data. ( Marson, AG; Nevitt, SJ; Sudell, M; Tudur Smith, C; Weston, J, 2017) |
| "Generalized epileptic seizures are underlied by specific circuits where GABAergic synapses are involved at different levels." | 2.40 | [GABAergic mechanisms in generalized epilepsies: the neuroanatomical dimension]. ( Depaulis, A; Deransart, C; Marescaux, C; Vergnes, M, 1997) |
| "Gabapentin has few drug-drug interactions, none of which is clinically limiting." | 2.40 | Gabapentin in the management of convulsive disorders. ( McLean, MJ, 1999) |
| " Therefore, gabapentin dosing must be optimized on an individual basis to achieve an adequate trial of the drug and obtain the best seizure control." | 2.40 | Gabapentin in the management of convulsive disorders. ( McLean, MJ, 1999) |
| "By contrast West syndrome is easier to evaluate as the spasms are the only, and characteristic, seizure type." | 2.39 | Vigabatrin in the management of generalized seizures in children. ( Appleton, RE, 1995) |
| "Vigabatrin has been used as both add-on, and monotherapy in the treatment of spasms." | 2.39 | Vigabatrin in the management of generalized seizures in children. ( Appleton, RE, 1995) |
| "Epilepsy is a common neurological disorder characterized by recurrent unprovoked seizures." | 1.72 | De novo Y1460C missense variant in Na ( Appendino, JP; Au, PYB; Chahine, M; Ebdalla, A; Plumereau, Q; Poulin, H; Scantlebury, MH, 2022) |
| "Epileptic activity in genetic generalized epilepsy (GGE) patients preferentially appears during sleep and its mechanism remains unknown." | 1.62 | Impaired State-Dependent Potentiation of GABAergic Synaptic Currents Triggers Seizures in a Genetic Generalized Epilepsy Model. ( Catron, MA; Ding, L; Gallagher, MJ; Hanna, CM; Macdonald, RL; Zhang, CQ; Zhou, C, 2021) |
| "Recurrent seizures (RS) were induced by flurothyl inhalation in immature rats." | 1.56 | Recurrent seizures cause immature brain injury and changes in GABA a receptor α1 and γ2 subunits. ( Feng, J; Hu, XY; Shi, XY; Tang, JH; Wan, Y; Xi, XJ; Zhang, BB; Zhou, C, 2020) |
| "We performed EEG recordings and autism diagnostic interview." | 1.56 | Endoplasmic reticulum retention and degradation of a mutation in SLC6A1 associated with epilepsy and autism. ( Cai, K; Delpire, E; Eissman, J; Flamm, C; Kang, JQ; Li, BM; Li, ZY; Liao, WP; Mermer, F; Nwosu, G; Poliquin, S; Shen, W; Shi, YW; Wang, J; Xu, D, 2020) |
| "We obtained seizures and once they had 3, 15 and 45 electric stimuli, the animals were sacrificed; the cerebellum was processed for inmunohistochemistry and Western blot analysis was performed to determine Sox-1 expression." | 1.43 | Decreased Expression of Sox-1 in Cerebellum of Rat with Generalized Seizures Induced by Kindling Model. ( Custodio, V; Eguiluz-Meléndez, A; González, E; Martínez-Lazcano, JC; Paz, C; Rosiles-Abonce, A; Rubio-Osornio, C; Rubio-Osornio, M; Trejo-Solís, C, 2016) |
| " The most commonly reported AEs were dizziness and somnolence, however, they were most pronounced during the first week of treatment, followed by a sharp fall in incidences across all dosing groups to <5% from Week 2 and onwards." | 1.35 | Add-on treatment with pregabalin for partial seizures with or without generalisation: pooled data analysis of four randomised placebo-controlled trials. ( Baldinetti, F; Gil-Nagel, A; Leon, T; Zaccara, G, 2009) |
| "Lamotrigine is a useful add-on therapy in treating children with epilepsy." | 1.33 | The use of lamotrigine, vigabatrin and gabapentin as add-on therapy in intractable epilepsy of childhood. ( Keegan, MB; Madden, D; McDonald, DG; McMenamin, JB; Najam, Y; Whooley, M, 2005) |
| " In contrast, biochemical study (based on dosage of plasma levels of GABA and diazepam binding inhibitor, an endogenous ligand of GABAA and peripheral benzodiazepine receptors, showed contradictory results: patients with Angelman's syndrome showed significantly higher levels of GABA and diazepam binding inhibitor than patients without neurologic impairment but significantly lower levels than epileptic controls." | 1.32 | Peripheral markers of the gamma-aminobutyric acid (GABA)ergic system in Angelman's syndrome. ( Borgatti, R; Cogliati, T; Elia, M; Ferrarese, C; Grasso, R; Musumeci, SA; Passoni, D; Piccinelli, P; Raggi, ME; Romeo, A; Valseriati, D; Viri, M, 2003) |
| "Here we describe a family that has generalized epilepsy with febrile seizures plus (GEFS(+)), including an individual with severe myoclonic epilepsy of infancy, in whom a third GABA(A)-receptor gamma2-subunit mutation was found." | 1.31 | Truncation of the GABA(A)-receptor gamma2 subunit in a family with generalized epilepsy with febrile seizures plus. ( Berkovic, SF; Bowser, DN; Dibbens, LM; Harkin, LA; Mulley, JC; Petrou, S; Phillips, F; Richards, MC; Scheffer, IE; Singh, R; Wallace, RH; Williams, DA, 2002) |
| " Both effects exhibited a tendency to a U-shaped dose-response curve." | 1.30 | Anticonvulsant action of gabapentin during postnatal development in rats. ( Haugvicová, R; Mares, P, 1997) |
| "Motor seizures were induced by pentylenetetrazol in 7-, 12-, 18-, 25-day-old, and adult rats." | 1.30 | Anticonvulsant action of gabapentin during postnatal development in rats. ( Haugvicová, R; Mares, P, 1997) |
| "In addition, minimal seizures were suppressed in 18-day-old rats." | 1.30 | Anticonvulsant action of gabapentin during postnatal development in rats. ( Haugvicová, R; Mares, P, 1997) |
| "In conclusion, the results confirm a genetic susceptibility in GAERS and/or resistance in inbred non-epileptic rats to focal and generalized seizures involving the cortex." | 1.30 | Susceptibility to focal and generalized seizures in Wistar rats with genetic absence-like epilepsy. ( Boehrer, A; Brailowsky, S; Marescaux, C; Montiel, T; Vergnes, M, 1999) |
| "Vigabatrin has a definite role to play in the management of persons with intractable complex partial seizures where standard anti-epileptic therapy has failed to achieve control." | 1.29 | Vigabatrin use in 72 patients with drug-resistant epilepsy. ( Buchanan, N, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 34 (47.22) | 18.2507 |
| 2000's | 15 (20.83) | 29.6817 |
| 2010's | 10 (13.89) | 24.3611 |
| 2020's | 13 (18.06) | 2.80 |
| Authors | Studies |
|---|---|
| Ahring, PK | 1 |
| Liao, VWY | 1 |
| Gardella, E | 1 |
| Johannesen, KM | 1 |
| Krey, I | 1 |
| Selmer, KK | 1 |
| Stadheim, BF | 1 |
| Davis, H | 1 |
| Peinhardt, C | 1 |
| Koko, M | 2 |
| Coorg, RK | 1 |
| Syrbe, S | 1 |
| Bertsche, A | 1 |
| Santiago-Sim, T | 1 |
| Diemer, T | 1 |
| Fenger, CD | 1 |
| Platzer, K | 2 |
| Eichler, EE | 1 |
| Lerche, H | 1 |
| Lemke, JR | 2 |
| Chebib, M | 1 |
| Møller, RS | 1 |
| Motelow, JE | 1 |
| Stanley, KE | 1 |
| Bobbili, DR | 1 |
| Dhindsa, RS | 1 |
| May, P | 1 |
| Chen, W | 1 |
| Ge, Y | 1 |
| Lu, J | 1 |
| Melo, J | 1 |
| So, YW | 1 |
| Juneja, R | 1 |
| Liu, L | 1 |
| Wang, YT | 1 |
| Gidal, B | 4 |
| Detyniecki, K | 1 |
| Kapur, J | 1 |
| Long, L | 1 |
| Dixon-Salazar, T | 1 |
| Sticht, H | 1 |
| Bupp, C | 1 |
| Ganapathi, M | 1 |
| Pereira, EM | 1 |
| Le Guyader, G | 1 |
| Bilan, F | 1 |
| Henderson, LB | 1 |
| Taschenberger, H | 1 |
| Brose, N | 1 |
| Abou Jamra, R | 1 |
| Wojcik, SM | 1 |
| Plumereau, Q | 1 |
| Ebdalla, A | 1 |
| Poulin, H | 1 |
| Appendino, JP | 1 |
| Scantlebury, MH | 1 |
| Au, PYB | 1 |
| Chahine, M | 1 |
| Chan, CK | 1 |
| Lim, KS | 1 |
| Low, SK | 1 |
| Tan, CT | 1 |
| Ng, CC | 1 |
| Khorram, E | 1 |
| Amini, M | 1 |
| Khorrami, M | 1 |
| Xi, XJ | 1 |
| Tang, JH | 1 |
| Zhang, BB | 1 |
| Shi, XY | 1 |
| Feng, J | 1 |
| Hu, XY | 1 |
| Wan, Y | 1 |
| Zhou, C | 2 |
| Wang, J | 2 |
| Poliquin, S | 1 |
| Mermer, F | 1 |
| Eissman, J | 1 |
| Delpire, E | 1 |
| Shen, W | 1 |
| Cai, K | 1 |
| Li, BM | 1 |
| Li, ZY | 1 |
| Xu, D | 1 |
| Nwosu, G | 1 |
| Flamm, C | 1 |
| Liao, WP | 1 |
| Shi, YW | 1 |
| Kang, JQ | 2 |
| Zhang, CQ | 1 |
| Catron, MA | 1 |
| Ding, L | 1 |
| Hanna, CM | 1 |
| Gallagher, MJ | 1 |
| Macdonald, RL | 3 |
| Gonen, OM | 1 |
| Moffat, BA | 1 |
| Desmond, PM | 1 |
| Lui, E | 1 |
| Kwan, P | 1 |
| O'Brien, TJ | 1 |
| Nevitt, SJ | 2 |
| Sudell, M | 2 |
| Weston, J | 2 |
| Tudur Smith, C | 2 |
| Marson, AG | 2 |
| Jiang, X | 1 |
| Lupien-Meilleur, A | 1 |
| Tazerart, S | 1 |
| Lachance, M | 1 |
| Samarova, E | 1 |
| Araya, R | 1 |
| Lacaille, JC | 1 |
| Rossignol, E | 1 |
| Bolden, LB | 1 |
| Griffis, JC | 1 |
| Nenert, R | 1 |
| Allendorfer, JB | 1 |
| Szaflarski, JP | 1 |
| Chowdhury, FA | 1 |
| O'Gorman, RL | 1 |
| Nashef, L | 1 |
| Elwes, RD | 1 |
| Edden, RA | 1 |
| Murdoch, JB | 1 |
| Barker, GJ | 3 |
| Richardson, MP | 1 |
| Petruccelli, E | 1 |
| Lansdon, P | 1 |
| Kitamoto, T | 1 |
| Rubio-Osornio, C | 1 |
| Eguiluz-Meléndez, A | 1 |
| Trejo-Solís, C | 1 |
| Custodio, V | 1 |
| Rubio-Osornio, M | 1 |
| Rosiles-Abonce, A | 1 |
| Martínez-Lazcano, JC | 1 |
| González, E | 1 |
| Paz, C | 1 |
| Gil-Nagel, A | 1 |
| Zaccara, G | 1 |
| Baldinetti, F | 1 |
| Leon, T | 1 |
| Gallego, JM | 1 |
| Ortiz, L | 1 |
| Gutiérrez, R | 1 |
| Barcia, JA | 1 |
| Nociti, V | 1 |
| Frisullo, G | 1 |
| Tartaglione, T | 1 |
| Patanella, AK | 1 |
| Iorio, R | 1 |
| Tonali, PA | 1 |
| Batocchi, AP | 1 |
| Igelström, KM | 1 |
| Shirley, CH | 1 |
| Heyward, PM | 1 |
| Borgatti, R | 1 |
| Piccinelli, P | 1 |
| Passoni, D | 1 |
| Romeo, A | 1 |
| Viri, M | 1 |
| Musumeci, SA | 1 |
| Elia, M | 1 |
| Cogliati, T | 1 |
| Valseriati, D | 1 |
| Grasso, R | 1 |
| Raggi, ME | 1 |
| Ferrarese, C | 1 |
| Meilleur, S | 1 |
| Aznavour, N | 1 |
| Descarries, L | 1 |
| Carmant, L | 2 |
| Mamer, OA | 1 |
| Psarropoulou, C | 1 |
| Simister, RJ | 2 |
| McLean, MA | 2 |
| Duncan, JS | 2 |
| Bianchi, MT | 1 |
| Bianch, MT | 1 |
| Feng, H | 1 |
| Alkan, A | 1 |
| Kutlu, R | 1 |
| Aslan, M | 1 |
| Sigirci, A | 1 |
| Orkan, I | 1 |
| Yakinci, C | 1 |
| French, JA | 3 |
| Kanner, AM | 3 |
| Bautista, J | 3 |
| Abou-Khalil, B | 4 |
| Browne, T | 3 |
| Harden, CL | 3 |
| Theodore, WH | 3 |
| Bazil, C | 3 |
| Stern, J | 3 |
| Schachter, SC | 3 |
| Bergen, D | 3 |
| Hirtz, D | 3 |
| Montouris, GD | 3 |
| Nespeca, M | 3 |
| Marks, WJ | 3 |
| Turk, WR | 3 |
| Fischer, JH | 3 |
| Bourgeois, B | 4 |
| Wilner, A | 3 |
| Faught, RE | 3 |
| Sachdeo, RC | 3 |
| Beydoun, A | 4 |
| Glauser, TA | 3 |
| McDonald, DG | 1 |
| Najam, Y | 1 |
| Keegan, MB | 1 |
| Whooley, M | 1 |
| Madden, D | 1 |
| McMenamin, JB | 1 |
| Zhu, GX | 1 |
| Ding, MP | 1 |
| Xiao, B | 1 |
| Wang, DX | 1 |
| Wang, DS | 1 |
| Pan, YZ | 1 |
| Zhao, QC | 1 |
| Pan, YF | 1 |
| Ma, GY | 1 |
| Hong, Z | 1 |
| Lü, CZ | 1 |
| Bauer, J | 1 |
| Elger, CE | 1 |
| Coenen, AM | 1 |
| Blezer, EH | 1 |
| van Luijtelaar, EL | 1 |
| Kelly, KM | 1 |
| Appleton, RE | 1 |
| Buchanan, N | 1 |
| Stolarek, I | 1 |
| Blacklaw, J | 1 |
| Forrest, G | 1 |
| Brodie, MJ | 1 |
| Walker, MC | 1 |
| Cockerell, OC | 1 |
| Sander, JW | 1 |
| Fisher, R | 1 |
| Kälviäinen, R | 1 |
| Tanganelli, P | 1 |
| Regesta, G | 1 |
| Sheth, RD | 1 |
| Buckley, D | 1 |
| Penney, S | 1 |
| Hobbs, GR | 1 |
| Schapel, G | 1 |
| Chadwick, D | 3 |
| Leiderman, DB | 2 |
| Sauermann, W | 1 |
| Alexander, J | 1 |
| Garofalo, E | 3 |
| Bergey, GK | 1 |
| Morris, HH | 1 |
| Rosenfeld, W | 1 |
| Blume, WT | 1 |
| Penovich, PE | 1 |
| Morrell, MJ | 1 |
| Crockatt, JG | 1 |
| LaMoreaux, L | 1 |
| Pierce, M | 2 |
| Fischer, J | 1 |
| Labar, DR | 1 |
| Harden, C | 1 |
| Cantrell, D | 1 |
| Uthman, BM | 1 |
| Sackellares, JC | 1 |
| Ramsay, RE | 1 |
| Hayes, A | 1 |
| Greiner, M | 1 |
| Panayiotopoulos, CP | 1 |
| Agathonikou, A | 1 |
| Sharoqi, IA | 1 |
| Parker, AP | 1 |
| Coppola, G | 1 |
| Terraciano, AM | 1 |
| Pascotto, A | 1 |
| Gherpelli, JL | 1 |
| Guerreiro, MM | 1 |
| da Costa, JC | 1 |
| Rotta, NT | 1 |
| Manreza, ML | 1 |
| Reed, UC | 1 |
| Diament, A | 1 |
| Silva, EA | 1 |
| Guerreiro, CA | 1 |
| Nunes, ML | 1 |
| Palmini, A | 1 |
| Vega-Gutiérrez, L | 1 |
| Vizioli, J | 1 |
| Pedroso, F | 1 |
| Chisté, MA | 1 |
| Schapel, GJ | 1 |
| Wallace, SJ | 1 |
| Gordon, GS | 1 |
| Mares, P | 1 |
| Haugvicová, R | 1 |
| Berkovic, SF | 2 |
| Ifergane, G | 1 |
| Masalha, R | 1 |
| Zigulinski, R | 1 |
| Merkin, L | 1 |
| Wirguin, I | 1 |
| Herishanu, YO | 1 |
| Depaulis, A | 2 |
| Deransart, C | 1 |
| Vergnes, M | 4 |
| Marescaux, C | 4 |
| Bélanger, S | 1 |
| Coulombe, G | 1 |
| de Toffol, B | 1 |
| Hommet, C | 1 |
| Corcia, P | 1 |
| Autret, A | 1 |
| Eriksson, AS | 1 |
| O'Connor, WT | 1 |
| Brailowsky, S | 3 |
| Montiel, T | 2 |
| Boehrer, A | 1 |
| McLean, MJ | 1 |
| Savic, I | 1 |
| Harkin, LA | 1 |
| Bowser, DN | 1 |
| Dibbens, LM | 1 |
| Singh, R | 1 |
| Phillips, F | 1 |
| Wallace, RH | 1 |
| Richards, MC | 1 |
| Williams, DA | 1 |
| Mulley, JC | 1 |
| Scheffer, IE | 1 |
| Petrou, S | 1 |
| Menini, C | 1 |
| Silva-Barrat, C | 1 |
| Riche, D | 1 |
| Naquet, R | 1 |
| Kostopoulos, G | 1 |
| Antoniadis, G | 1 |
| Daval, JL | 1 |
| Pereira de Vasconcelos, A | 1 |
| el Hamdi, G | 1 |
| Werck, MC | 1 |
| Nehlig, A | 1 |
| Bowery, NG | 1 |
| Bagetta, G | 1 |
| Nisticó, G | 1 |
| Britton, P | 1 |
| Whitton, P | 1 |
| Hernández, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phenylbutyrate for Monogenetic Developmental and Epileptic Encephalopathy[NCT04937062] | Early Phase 1 | 50 participants (Anticipated) | Interventional | 2021-03-01 | Enrolling by invitation | ||
| Phase 3: Metabolism of Lamotrigine During Treatment With Oral Contraceptives[NCT00266149] | Phase 3 | 10 participants | Interventional | 2003-06-30 | Terminated | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
16 reviews available for gamma-aminobutyric acid and Convulsive Generalized Seizure Disorder
| Article | Year |
|---|---|
Rescue therapies for seizure clusters: Pharmacology and target of treatments.
Topics: Administration, Intranasal; Adolescent; Adult; Anticonvulsants; Benzodiazepines; Diazepam; Epilepsy, | 2022 |
Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.
Topics: Adult; Amines; Anticonvulsants; Carbamazepine; Child; Cyclohexanecarboxylic Acids; Epilepsies, Parti | 2017 |
Defects at the crossroads of GABAergic signaling in generalized genetic epilepsies.
Topics: Animals; Epilepsy, Generalized; GABAergic Neurons; gamma-Aminobutyric Acid; Humans; Receptors, GABA; | 2017 |
Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.
Topics: Adult; Amines; Anticonvulsants; Carbamazepine; Child; Cyclohexanecarboxylic Acids; Epilepsies, Parti | 2017 |
Efficacy and tolerability of the new antiepileptic drugs, I: Treatment of new-onset epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society.
Topics: Acetates; Adolescent; Adult; Age Factors; Amines; Antipsychotic Agents; Carbamazepine; Child; Clinic | 2004 |
Efficacy and tolerability of the new antiepileptic drugs, II: Treatment of refractory epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society.
Topics: Acetates; Adolescent; Adult; Age Factors; Amines; Anticonvulsants; Carbamazepine; Child; Clinical Tr | 2004 |
Efficacy and tolerability of the new antiepileptic drugs II: treatment of refractory epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epile
Topics: Acetates; Adult; Amines; Anticonvulsants; Carbamazepine; Child; Clinical Trials as Topic; Cyclohexan | 2004 |
[Anticonvulsive drug therapy. Historical and current aspects].
Topics: Animals; Anticonvulsants; Brain; Drug Therapy, Combination; Electroencephalography; Epilepsies, Part | 1995 |
Antiepileptic drug mechanisms of action.
Topics: Acetates; Action Potentials; Amines; Anticonvulsants; Calcium Channels; Cyclohexanecarboxylic Acids; | 1993 |
Vigabatrin in the management of generalized seizures in children.
Topics: Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Electroencephalography; Epileps | 1995 |
Clinical use of drugs useful in the treatment of atonic seizures.
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Clobazam; Epilepsy, Genera | 1995 |
Aggravation of generalized epilepsies.
Topics: Acute Disease; Anticonvulsants; Carbamazepine; Epilepsy, Generalized; gamma-Aminobutyric Acid; Human | 1998 |
[GABAergic mechanisms in generalized epilepsies: the neuroanatomical dimension].
Topics: Animals; Central Nervous System; Disease Models, Animal; Epilepsy, Generalized; gamma-Aminobutyric A | 1997 |
[Anticonvulsants can aggravate idiopathic generalized epilepsy].
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Epilepsies, Myoclonic; Epilepsy, Ab | 1998 |
Gabapentin in the management of convulsive disorders.
Topics: Acetates; Action Potentials; Amines; Animals; Anticonvulsants; Clinical Trials as Topic; Cyclohexane | 1999 |
PET: central benzodiazepine neuroreceptor mapping in generalized epilepsies.
Topics: Cerebral Cortex; Epilepsy, Generalized; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Humans | 2000 |
11 trials available for gamma-aminobutyric acid and Convulsive Generalized Seizure Disorder
| Article | Year |
|---|---|
Proton MRS reveals frontal lobe metabolite abnormalities in idiopathic generalized epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Aspartic Acid; Carnosine; Epilepsy, Generalized; Female; Frontal | 2003 |
[Curative effect of gabapentin on refractory epilepsy].
Topics: Adolescent; Adult; Aged; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Double-Blind Method; | 2005 |
Vigabatrin and lamotrigine in refractory epilepsy.
Topics: Anticonvulsants; Double-Blind Method; Drug Monitoring; Drug Therapy, Combination; Epilepsy, Complex | 1994 |
Newer antiepileptic drugs as monotherapy: data on vigabatrin.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cross-Over Studies | 1996 |
Vigabatrin in childhood epilepsy: comparable efficacy for generalized and partial seizures.
Topics: Adolescent; Adult; Child; Child, Preschool; Enzyme Inhibitors; Epilepsies, Partial; Epilepsy, Genera | 1996 |
Gabapentin in generalized seizures.
Topics: Acetates; Adolescent; Adult; Amines; Analysis of Variance; Anticonvulsants; Cyclohexanecarboxylic Ac | 1996 |
Gabapentin monotherapy: I. An 8-day, double-blind, dose-controlled, multicenter study in hospitalized patients with refractory complex partial or secondarily generalized seizures. The US Gabapentin Study Group 88/89.
Topics: Acetates; Adolescent; Adult; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Dose-Response Rel | 1997 |
Gabapentin monotherapy: II. A 26-week, double-blind, dose-controlled, multicenter study of conversion from polytherapy in outpatients with refractory complex partial or secondarily generalized seizures. The US Gabapentin Study Group 82/83.
Topics: Acetates; Adolescent; Adult; Ambulatory Care; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecar | 1997 |
Vigabatrin as add-on therapy in children and adolescents with refractory epilepsy: an open trial.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Drug Resistance; Drug Therapy, Combinat | 1997 |
Vigabatrin in refractory childhood epilepsy. The Brazilian Multicenter Study.
Topics: Adolescent; Anticonvulsants; Brazil; Child; Child, Preschool; Epilepsies, Partial; Epilepsy, General | 1997 |
Gabapentin.
Topics: Acetates; Adolescent; Adult; Aged; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Dose-Respon | 1991 |
45 other studies available for gamma-aminobutyric acid and Convulsive Generalized Seizure Disorder
| Article | Year |
|---|---|
Gain-of-function variants in GABRD reveal a novel pathway for neurodevelopmental disorders and epilepsy.
Topics: Autism Spectrum Disorder; Epilepsy; Epilepsy, Generalized; GABA Plasma Membrane Transport Proteins; | 2022 |
Association of ultra-rare coding variants with genetic generalized epilepsy: A case-control whole exome sequencing study.
Topics: Case-Control Studies; Epilepsy, Generalized; Exome Sequencing; gamma-Aminobutyric Acid; Genetic Pred | 2022 |
Distinct Functional Alterations and Therapeutic Options of Two Pathological De Novo Variants of the T292 Residue of GABRA1 Identified in Children with Epileptic Encephalopathy and Neurodevelopmental Disorders.
Topics: Animals; Child; Epilepsy; Epilepsy, Generalized; gamma-Aminobutyric Acid; HEK293 Cells; Humans; Muta | 2022 |
Consequences: Bench to home.
Topics: Chlorides; Epilepsy, Generalized; gamma-Aminobutyric Acid; Humans; Quality of Life; Receptors, GABA- | 2022 |
De Novo Missense Variants in SLC32A1 Cause a Developmental and Epileptic Encephalopathy Due to Impaired GABAergic Neurotransmission.
Topics: Amino Acid Transport Systems; Animals; Epilepsy; Epilepsy, Generalized; gamma-Aminobutyric Acid; Mic | 2022 |
De novo Y1460C missense variant in Na
Topics: Action Potentials; Epilepsy; Epilepsy, Generalized; gamma-Aminobutyric Acid; HEK293 Cells; Humans; N | 2022 |
Genetic interaction between GABRA1 and ERBB4 variants in the pathogenesis of genetic generalized epilepsy.
Topics: Epilepsy; Epilepsy, Generalized; Family; gamma-Aminobutyric Acid; Humans; Receptor, ErbB-4; Receptor | 2023 |
Developmental and epileptic encephalopathy 89: A novel bi-allelic variant, molecular dynamics simulation, and a comprehensive clinical and molecular profile.
Topics: Adult; Cleft Palate; Epilepsy; Epilepsy, Generalized; gamma-Aminobutyric Acid; Humans; Molecular Doc | 2023 |
Recurrent seizures cause immature brain injury and changes in GABA a receptor α1 and γ2 subunits.
Topics: Animals; Brain; Brain Injuries; Epilepsy, Generalized; Female; Flurothyl; gamma-Aminobutyric Acid; H | 2020 |
Endoplasmic reticulum retention and degradation of a mutation in SLC6A1 associated with epilepsy and autism.
Topics: Amino Acid Sequence; Animals; Autistic Disorder; Cell Line; Child; Electroencephalography; Endoplasm | 2020 |
Impaired State-Dependent Potentiation of GABAergic Synaptic Currents Triggers Seizures in a Genetic Generalized Epilepsy Model.
Topics: Action Potentials; Animals; Electroencephalography; Electrophysiological Phenomena; Epilepsy, Genera | 2021 |
Seven-tesla quantitative magnetic resonance spectroscopy of glutamate, γ-aminobutyric acid, and glutathione in the posterior cingulate cortex/precuneus in patients with epilepsy.
Topics: Adult; Aged; Case-Control Studies; Epilepsy; Epilepsy, Generalized; Epilepsy, Temporal Lobe; gamma-A | 2020 |
Remodeled cortical inhibition prevents motor seizures in generalized epilepsy.
Topics: Animals; Cerebral Cortex; Epilepsy, Generalized; GABAergic Neurons; gamma-Aminobutyric Acid; Interne | 2018 |
Cortical excitability and seizure control influence attention performance in patients with idiopathic generalized epilepsies (IGEs).
Topics: Adult; Analysis of Variance; Attention; Case-Control Studies; Cognition; Cortical Excitability; Epil | 2018 |
Investigation of glutamine and GABA levels in patients with idiopathic generalized epilepsy using MEGAPRESS.
Topics: Adult; Epilepsy, Generalized; Female; Frontal Lobe; gamma-Aminobutyric Acid; Glutamine; Humans; Imag | 2015 |
Exaggerated Nighttime Sleep and Defective Sleep Homeostasis in a Drosophila Knock-In Model of Human Epilepsy.
Topics: Animals; Animals, Genetically Modified; Circadian Rhythm; Disease Models, Animal; Disease Susceptibi | 2015 |
Decreased Expression of Sox-1 in Cerebellum of Rat with Generalized Seizures Induced by Kindling Model.
Topics: Amygdala; Animals; Blotting, Western; Cerebellum; Chromatography, High Pressure Liquid; Disease Mode | 2016 |
Add-on treatment with pregabalin for partial seizures with or without generalisation: pooled data analysis of four randomised placebo-controlled trials.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analysis of Variance; Anticonvulsants; Child; Dose-Respo | 2009 |
Continuous bilateral infusion of GABA in the dorsomedian nucleus of the thalamus elevates the generalized seizure threshold in amygdala-kindled rats.
Topics: Amygdala; Animals; Disease Models, Animal; Electric Stimulation; Epilepsy, Generalized; Functional L | 2009 |
Refractory generalized seizures and cerebellar ataxia associated with anti-GAD antibodies responsive to immunosuppressive treatment.
Topics: Adult; Anticonvulsants; Autoantibodies; Autoimmune Diseases; Azathioprine; Biomarkers; Brain; Cerebe | 2010 |
Low-magnesium medium induces epileptiform activity in mouse olfactory bulb slices.
Topics: Action Potentials; Acute Disease; Animals; Animals, Outbred Strains; Anticonvulsants; Culture Media; | 2011 |
Peripheral markers of the gamma-aminobutyric acid (GABA)ergic system in Angelman's syndrome.
Topics: Adolescent; Adult; Angelman Syndrome; Child; Child, Preschool; Chromosome Banding; Chromosome Deleti | 2003 |
Pentylenetetrazol-induced seizures in immature rats provoke long-term changes in adult hippocampal cholinergic excitability.
Topics: Acetylcholine; Age Factors; Animals; Animals, Newborn; Cholinergic Fibers; Cholinesterase Inhibitors | 2003 |
A proton magnetic resonance spectroscopy study of metabolites in the occipital lobes in epilepsy.
Topics: Adolescent; Adult; Aspartic Acid; Carnosine; Epilepsies, Partial; Epilepsy, Generalized; Female; gam | 2003 |
Mutations linked to generalized epilepsy in humans reduce GABA(A) receptor current.
Topics: Amino Acids, Basic; Animals; Cell Line; Diazepam; Dose-Response Relationship, Drug; Drug Interaction | 2003 |
Pyridoxine-dependent seizures: magnetic resonance spectroscopy findings.
Topics: Aspartic Acid; Brain Damage, Chronic; Child; Choline; Consanguinity; Creatine; Diagnosis, Differenti | 2004 |
The use of lamotrigine, vigabatrin and gabapentin as add-on therapy in intractable epilepsy of childhood.
Topics: Amines; Anticonvulsants; Child; Child, Preschool; Cyclohexanecarboxylic Acids; Drug Therapy, Combina | 2005 |
Effects of the GABA-uptake inhibitor tiagabine on electroencephalogram, spike-wave discharges and behaviour of rats.
Topics: Action Potentials; Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Electroenceph | 1995 |
Vigabatrin use in 72 patients with drug-resistant epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Child; Drug Therapy, Combination; Electroencephalography; Epilep | 1994 |
Vigabatrin and carbamazepine monotherapy for newly diagnosed epilepsy.
Topics: Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Electroencephalography; Epilepsies | 1996 |
A survey comparing lamotrigine and vigabatrin in everyday clinical practice.
Topics: Anticonvulsants; Electroencephalography; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized; Epile | 1996 |
Vigabatrin aggravates absences and absence status.
Topics: Adult; Anticonvulsants; Electroencephalography; Epilepsy, Absence; Epilepsy, Generalized; gamma-Amin | 1997 |
A survey of lamotrigine and vigabatrin treatment in children with severe epilepsy.
Topics: Adolescent; Anticonvulsants; Child; Drug Therapy, Combination; Electroencephalography; Epilepsies, P | 1997 |
Anticonvulsant action of gabapentin during postnatal development in rats.
Topics: Acetates; Amines; Animals; Anticonvulsants; Behavior, Animal; Brain; Cyclohexanecarboxylic Acids; Do | 1997 |
Acute encephalopathy associated with vigabatrin monotherapy in patients with mild renal failure.
Topics: Acute Disease; Adult; Aged; Anticonvulsants; Electroencephalography; Encephalitis; Epilepsy, General | 1998 |
Role of vigabatrin and lamotrigine in treatment of childhood epileptic syndromes.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; | 1998 |
Analysis of CSF amino acids in young patients with generalised refractory epilepsy during an add-on study with lamotrigine.
Topics: Adolescent; Adult; Amino Acids; Anticonvulsants; Aspartic Acid; Child; Child, Preschool; Drug Resist | 1999 |
Susceptibility to focal and generalized seizures in Wistar rats with genetic absence-like epilepsy.
Topics: Animals; Convulsants; Electroencephalography; Epilepsies, Partial; Epilepsy, Absence; Epilepsy, Gene | 1999 |
Truncation of the GABA(A)-receptor gamma2 subunit in a family with generalized epilepsy with febrile seizures plus.
Topics: Animals; Base Sequence; Cell Line; Codon, Terminator; Electrophysiology; Endoplasmic Reticulum; Epil | 2002 |
Cortical GABAergic control of epilepsy in photosensitive baboons.
Topics: Animals; Cerebral Cortex; Electroencephalography; Epilepsies, Partial; Epilepsy, Generalized; gamma- | 1992 |
Active role of cortical inhibition in the development of generalized epilepsy with spike-and-wave discharges: evidence from electrophysiological, microiontophoretic and simulation studies.
Topics: Animals; Bicuculline; Cats; Cerebral Cortex; Computer Simulation; Electroencephalography; Epilepsy, | 1992 |
Quantitative autoradiographic measurements of functional changes induced by generalized seizures in the developing rat brain: central adenosine and benzodiazepine receptors and local cerebral glucose utilization.
Topics: Age Factors; Animals; Autoradiography; Bicuculline; Blood Glucose; Brain; Brain Mapping; Epilepsy, G | 1992 |
Neurotransmission in rats' spontaneous generalized nonconvulsive epilepsy.
Topics: Animals; Brain Mapping; Cerebral Cortex; Dopamine; Electroencephalography; Epilepsy, Generalized; ga | 1992 |
Intrahippocampal tetanus toxin produces generalized convulsions and neurodegeneration in rats: antagonism by NMDA receptor blockers.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Carbamazepine; Diazepam; Dizocilpine Maleate; | 1992 |
Effects of 3-hydroxy,3-ethyl,3-phenylpropionamide (HEPP) on rat models of generalized and focal epilepsy.
Topics: Animals; Anticonvulsants; Electroencephalography; Epilepsies, Partial; Epilepsy, Generalized; gamma- | 1992 |