gamma-aminobutyric acid has been researched along with Convulsions, Grand Mal in 35 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine whether seizures have age-specific features, we studied the role of gamma-aminobutyric acidB (GABAB) transmission in rats of various ages (9, 15, 30, and 60 postnatal days)." | 7.69 | Age-specific effects of baclofen on pentylenetetrazol-induced seizures in developing rats. ( Moshé, SL; Velísek, L; Velísková, J, 1996) |
| "Vigabatrin is a specific and irreversible inhibitor of the enzyme gamma-amino-butyric-acid (GABA) transferase." | 6.39 | [Vigabatrin and lamotrigin: experiences with 2 new anticonvulsants in the Swiss epilepsy clinic]. ( Krämer, G; Vogt, H, 1995) |
| "To determine whether seizures have age-specific features, we studied the role of gamma-aminobutyric acidB (GABAB) transmission in rats of various ages (9, 15, 30, and 60 postnatal days)." | 5.29 | Age-specific effects of baclofen on pentylenetetrazol-induced seizures in developing rats. ( Moshé, SL; Velísek, L; Velísková, J, 1996) |
| "These audiogenic-like seizures were blocked by clobazam microinjection into the substantia nigra (SN) and partially modified by SN vehicle injection." | 5.28 | Neuroethological evaluation of audiogenic seizures and audiogenic-like seizures induced by microinjection of bicuculline into the inferior colliculus. II. Effects of nigral clobazam microinjections. ( Garcia-Cairasco, N; Terra, VC, 1992) |
| "Audiogenic seizures (AS) are a model of generalized tonic-clonic seizures." | 5.28 | Neuroethological evaluation of audiogenic seizures and audiogenic-like seizures induced by microinjection of bicuculline into the inferior colliculus. I. Effects of midcollicular knife cuts. ( Garcia-Cairasco, N; Oliveira, JA; Terra, VC; Tsutsui, J, 1992) |
| "To determine whether seizures have age-specific features, we studied the role of gamma-aminobutyric acidB (GABAB) transmission in rats of various ages (9, 15, 30, and 60 postnatal days)." | 3.69 | Age-specific effects of baclofen on pentylenetetrazol-induced seizures in developing rats. ( Moshé, SL; Velísek, L; Velísková, J, 1996) |
| "Gamma-Aminobutyric acid (GABA) has been implicated in the neurochemistry of epilepsy." | 3.66 | Low cerebrospinal fluid gamma-aminobutyric acid content in seizure patients. ( Ballenger, JC; Glaeser, BS; Hare, TA; Post, RM; Wood, JH, 1979) |
| "Vigabatrin is a specific and irreversible inhibitor of the enzyme gamma-amino-butyric-acid (GABA) transferase." | 2.39 | [Vigabatrin and lamotrigin: experiences with 2 new anticonvulsants in the Swiss epilepsy clinic]. ( Krämer, G; Vogt, H, 1995) |
| "Valproic acid is a new antiepileptic drug." | 2.36 | Valproic acid. Review of a new antiepileptic drug. ( Bruni, J; Wilder, BJ, 1979) |
| "An extreme example is Dravet syndrome (DS), an infantile-onset severe epilepsy caused by heterozygous loss of function mutations in SCN1A, the gene encoding the brain type-I voltage-gated sodium channel NaV1." | 1.39 | Synergistic GABA-enhancing therapy against seizures in a mouse model of Dravet syndrome. ( Catterall, WA; Cheah, CS; Cho, AR; Oakley, JC; Scheuer, T, 2013) |
| "We found 3 cases (1." | 1.35 | [Development or worsening of myoclonus associated with gabapentin therapy]. ( Ikeda, H; Inoue, Y; Koide, Y, 2009) |
| "Pretreatment with bumetanide (0." | 1.35 | Age- and dose-specific anticonvulsant action of bumetanide in immature rats. ( Mares, P, 2009) |
| "Bumetanide is a specific inhibitor of this cotransporter." | 1.35 | Age- and dose-specific anticonvulsant action of bumetanide in immature rats. ( Mares, P, 2009) |
| " Both effects exhibited a tendency to a U-shaped dose-response curve." | 1.30 | Anticonvulsant action of gabapentin during postnatal development in rats. ( Haugvicová, R; Mares, P, 1997) |
| "Motor seizures were induced by pentylenetetrazol in 7-, 12-, 18-, 25-day-old, and adult rats." | 1.30 | Anticonvulsant action of gabapentin during postnatal development in rats. ( Haugvicová, R; Mares, P, 1997) |
| "In addition, minimal seizures were suppressed in 18-day-old rats." | 1.30 | Anticonvulsant action of gabapentin during postnatal development in rats. ( Haugvicová, R; Mares, P, 1997) |
| "To determine whether seizures have age-specific features, we studied the role of gamma-aminobutyric acidB (GABAB) transmission in rats of various ages (9, 15, 30, and 60 postnatal days)." | 1.29 | Age-specific effects of baclofen on pentylenetetrazol-induced seizures in developing rats. ( Moshé, SL; Velísek, L; Velísková, J, 1996) |
| "These audiogenic-like seizures were blocked by clobazam microinjection into the substantia nigra (SN) and partially modified by SN vehicle injection." | 1.28 | Neuroethological evaluation of audiogenic seizures and audiogenic-like seizures induced by microinjection of bicuculline into the inferior colliculus. II. Effects of nigral clobazam microinjections. ( Garcia-Cairasco, N; Terra, VC, 1992) |
| "Audiogenic seizures (AS) are a model of generalized tonic-clonic seizures." | 1.28 | Neuroethological evaluation of audiogenic seizures and audiogenic-like seizures induced by microinjection of bicuculline into the inferior colliculus. I. Effects of midcollicular knife cuts. ( Garcia-Cairasco, N; Oliveira, JA; Terra, VC; Tsutsui, J, 1992) |
| "gamma-Aminobutyric acid (GABA) levels were determined in cisternal cerebrospinal fluid (CSF) of 19 epileptic dogs with generalized tonic-clonic (grand mal) seizures using a radioreceptor assay." | 1.27 | Low levels of gamma-aminobutyric acid in cerebrospinal fluid of dogs with epilepsy. ( Löscher, W; Schwartz-Porsche, D, 1986) |
| "Treatment with phenobarbital or primidone seemed not to affect CSF GABA levels." | 1.27 | Low levels of gamma-aminobutyric acid in cerebrospinal fluid of dogs with epilepsy. ( Löscher, W; Schwartz-Porsche, D, 1986) |
| "Gamma-Aminobutyric acid (GABA) has been implicated in the neurochemistry of epilepsy." | 1.26 | Low cerebrospinal fluid gamma-aminobutyric acid content in seizure patients. ( Ballenger, JC; Glaeser, BS; Hare, TA; Post, RM; Wood, JH, 1979) |
| "Although lumbar CSF GABA levels in our seizure patients did not significantly correlate with serum concentrations of phenytoin, phenobarbital, or primidone, additional study of medication-free epileptic patients may be required to evaluate the possibility of anticonvulsant-drug-induced CSF GABA alterations." | 1.26 | Low cerebrospinal fluid gamma-aminobutyric acid content in seizure patients. ( Ballenger, JC; Glaeser, BS; Hare, TA; Post, RM; Wood, JH, 1979) |
| "The types of seizure patterns were classed as major (including focal) and minor (akinetic, myoclonic and hypsarrhythmic) and the patients were followed for up to one year." | 1.24 | Trial of amino-oxyacetic acid, an anticonvulsant. ( McGREAL, DA; TIBBLES, JA, 1963) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (25.71) | 18.7374 |
| 1990's | 16 (45.71) | 18.2507 |
| 2000's | 7 (20.00) | 29.6817 |
| 2010's | 3 (8.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Oakley, JC | 1 |
| Cho, AR | 1 |
| Cheah, CS | 1 |
| Scheuer, T | 1 |
| Catterall, WA | 1 |
| Shakarjian, MP | 1 |
| Ali, MS | 1 |
| Velíšková, J | 2 |
| Stanton, PK | 1 |
| Heck, DE | 1 |
| Velíšek, L | 2 |
| Stewart, LS | 1 |
| Nylen, KJ | 1 |
| Persinger, MA | 1 |
| Cortez, MA | 1 |
| Gibson, KM | 1 |
| Snead, OC | 1 |
| Kalaci, A | 1 |
| Duru, M | 1 |
| Karazincir, S | 1 |
| Sevinç, TT | 1 |
| Kuvandik, G | 1 |
| Balci, A | 1 |
| Koide, Y | 1 |
| Ikeda, H | 1 |
| Inoue, Y | 1 |
| Mares, P | 2 |
| González-Ramírez, M | 1 |
| Razo-Juárez, LI | 1 |
| Sauer-Ramírez, JL | 1 |
| González-Trujano, ME | 1 |
| Salgado-Ceballos, H | 1 |
| Orozco-Suarez, S | 1 |
| TIBBLES, JA | 1 |
| McGREAL, DA | 1 |
| NISHIMOTO, A | 1 |
| MORI, A | 1 |
| TAKASHITA, H | 1 |
| NAMBA, H | 1 |
| Taylor, CP | 1 |
| Angelotti, T | 1 |
| Fauman, E | 1 |
| Nassiri-Asl, M | 1 |
| Shariati-Rad, S | 1 |
| Zamansoltani, F | 1 |
| Spero, L | 1 |
| Rowley, HL | 1 |
| Martin, KF | 1 |
| Marsden, CA | 1 |
| Short, C | 1 |
| Cooke, L | 1 |
| Marciani, MG | 1 |
| Maschio, M | 1 |
| Spanedda, F | 1 |
| Iani, C | 1 |
| Gigli, GL | 1 |
| Bernardi, G | 1 |
| Vogt, H | 1 |
| Krämer, G | 1 |
| Pierce, MW | 1 |
| Shu, VS | 1 |
| Moshé, SL | 1 |
| Schapel, G | 1 |
| Chadwick, D | 1 |
| Scotti, AL | 1 |
| Bollag, O | 1 |
| Kalt, G | 1 |
| Nitsch, C | 1 |
| MacGregor, DG | 1 |
| Graham, DI | 1 |
| Stone, TW | 1 |
| Haugvicová, R | 1 |
| Baulac, M | 1 |
| Nordmann, JP | 1 |
| Lanoé, Y | 1 |
| Cocito, L | 1 |
| Primavera, A | 1 |
| Delvaux, V | 1 |
| Alagona, G | 1 |
| Gérard, P | 1 |
| De Pasqua, V | 1 |
| Delwaide, PJ | 1 |
| Maertens de Noordhout, A | 1 |
| Bruni, J | 1 |
| Wilder, BJ | 1 |
| Wood, JH | 2 |
| Hare, TA | 2 |
| Glaeser, BS | 2 |
| Ballenger, JC | 1 |
| Post, RM | 1 |
| Achar, VS | 1 |
| Welch, KM | 1 |
| Chabi, E | 1 |
| Bartosh, K | 1 |
| Meyer, JS | 1 |
| Sode, J | 1 |
| Brooks, BR | 1 |
| Van Buren, JM | 1 |
| Terra, VC | 2 |
| Garcia-Cairasco, N | 2 |
| Tsutsui, J | 1 |
| Oliveira, JA | 1 |
| Kolasa, K | 1 |
| Kleinrok, Z | 1 |
| Consolo, S | 1 |
| Ferrario, P | 1 |
| Zecca, L | 1 |
| Karbon, EW | 1 |
| Enna, SJ | 1 |
| Ferkany, JW | 1 |
| Kurlemann, G | 1 |
| Palm, DG | 1 |
| Löscher, W | 1 |
| Schwartz-Porsche, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Exploratory Study on the Use of Pregabalin for the Treatment of Taxol Related Arthralgia-Myalgia[NCT02024568] | Phase 2 | 38 participants (Anticipated) | Interventional | 2013-12-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for gamma-aminobutyric acid and Convulsions, Grand Mal
| Article | Year |
|---|---|
Pharmacology and mechanism of action of pregabalin: the calcium channel alpha2-delta (alpha2-delta) subunit as a target for antiepileptic drug discovery.
Topics: Amines; Amino Acid Sequence; Animals; Anticonvulsants; Calcium Channels; Cyclohexanecarboxylic Acids | 2007 |
[Vigabatrin and lamotrigin: experiences with 2 new anticonvulsants in the Swiss epilepsy clinic].
Topics: 4-Aminobutyrate Transaminase; Adult; Anticonvulsants; Child; Drug Therapy, Combination; Epilepsies, | 1995 |
Handling seizure data: special problems.
Topics: Anticonvulsants; Clinical Trials as Topic; Data Interpretation, Statistical; Drug Therapy, Combinati | 1993 |
Valproic acid. Review of a new antiepileptic drug.
Topics: Adolescent; Adult; Animals; Brain Chemistry; Drug Interactions; Electric Stimulation; Electroencepha | 1979 |
31 other studies available for gamma-aminobutyric acid and Convulsions, Grand Mal
| Article | Year |
|---|---|
Synergistic GABA-enhancing therapy against seizures in a mouse model of Dravet syndrome.
Topics: Animals; Anticonvulsants; Clonazepam; Dose-Response Relationship, Drug; Drug Synergism; Epilepsies, | 2013 |
Combined diazepam and MK-801 therapy provides synergistic protection from tetramethylenedisulfotetramine-induced tonic-clonic seizures and lethality in mice.
Topics: Animals; Anticonvulsants; Brain Waves; Bridged-Ring Compounds; Central Nervous System; Diazepam; Dis | 2015 |
Circadian distribution of generalized tonic-clonic seizures associated with murine succinic semialdehyde dehydrogenase deficiency, a disorder of GABA metabolism.
Topics: Age Factors; Animals; Brain; Circadian Rhythm; Disease Models, Animal; Epilepsy, Tonic-Clonic; gamma | 2008 |
Thoracic spine compression fracture during isoniazid-induced seizures: case report.
Topics: Antidotes; Back Pain; Charcoal; Child; Drug Overdose; Epilepsy, Tonic-Clonic; Female; Fractures, Com | 2008 |
[Development or worsening of myoclonus associated with gabapentin therapy].
Topics: Adult; Amines; Anticonvulsants; Contraindications; Cyclohexanecarboxylic Acids; Epilepsy, Tonic-Clon | 2009 |
Age- and dose-specific anticonvulsant action of bumetanide in immature rats.
Topics: Age Factors; Aging; Animals; Anticonvulsants; Bumetanide; Disease Models, Animal; Dose-Response Rela | 2009 |
Anticonvulsive effect of vitamin C on pentylenetetrazol-induced seizures in immature rats.
Topics: Animals; Anticonvulsants; Ascorbic Acid; Aspartic Acid; Brain Chemistry; Chromatography, High Pressu | 2010 |
Trial of amino-oxyacetic acid, an anticonvulsant.
Topics: Amino Acids; Anticonvulsants; Brain; Child; Epilepsy; Epilepsy, Tonic-Clonic; gamma-Aminobutyric Aci | 1963 |
TREATMENT OF EPILEPSY BY INTRASPINAL INJECTION OF GAMMA-AMINO-BETA-HYDROXYBUTYRIC ACID (GABOB).
Topics: Adolescent; Anticonvulsants; Drug Therapy; Electroencephalography; Epilepsy; Epilepsy, Tonic-Clonic; | 1964 |
Anticonvulsive effects of intracerebroventricular administration of rutin in rats.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Dose-Response Relationship, Drug; Epilepsy, Tonic-Clon | 2008 |
Epilepsy.
Topics: Anticonvulsants; Brain; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; gamma-Aminobutyric Acid | 1982 |
Decreased GABA release following tonic-clonic seizures is associated with an increase in extracellular glutamate in rat hippocampus in vivo.
Topics: Amino Acids; Animals; Anticonvulsants; Bicuculline; Calcium; Electroshock; Epilepsy, Tonic-Clonic; E | 1995 |
Hypomania induced by gabapentin.
Topics: Acetates; Amines; Anticonvulsants; Bipolar Disorder; Cyclohexanecarboxylic Acids; Dose-Response Rela | 1995 |
Development of myoclonus in patients with partial epilepsy during treatment with vigabatrin: an electroencephalographic study.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Brain; Carbamazepine; Delta Rhythm; Electroencephalography | 1995 |
Age-specific effects of baclofen on pentylenetetrazol-induced seizures in developing rats.
Topics: Age Factors; Animals; Animals, Newborn; Baclofen; Dose-Response Relationship, Drug; Epilepsy, Tonic- | 1996 |
A survey comparing lamotrigine and vigabatrin in everyday clinical practice.
Topics: Anticonvulsants; Electroencephalography; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized; Epile | 1996 |
Loss of perikaryal parvalbumin immunoreactivity from surviving GABAergic neurons in the CA1 field of epileptic gerbils.
Topics: Animals; Arousal; Epilepsy; Epilepsy, Tonic-Clonic; gamma-Aminobutyric Acid; Gerbillinae; Hippocampu | 1997 |
The attenuation of kainate-induced neurotoxicity by chlormethiazole and its enhancement by dizocilpine, muscimol, and adenosine receptor agonists.
Topics: Adenosine; Animals; Body Temperature; Chlormethiazole; Dizocilpine Maleate; Drug Synergism; Drug The | 1997 |
Anticonvulsant action of gabapentin during postnatal development in rats.
Topics: Acetates; Amines; Animals; Anticonvulsants; Behavior, Animal; Brain; Cyclohexanecarboxylic Acids; Do | 1997 |
Severe visual-field constriction and side-effects of GABA-mimetic antiepileptic agents.
Topics: Anticonvulsants; Epilepsies, Myoclonic; Epilepsy, Tonic-Clonic; Female; Follow-Up Studies; GABA Agon | 1998 |
Vigabatrin aggravates absences and absence status.
Topics: Adult; Anticonvulsants; Asphyxia; Brain Damage, Chronic; Carbamazepine; Drug Therapy, Combination; E | 1998 |
Reduced excitability of the motor cortex in untreated patients with de novo idiopathic "grand mal" seizures.
Topics: Adolescent; Adult; Aged; Case-Control Studies; Electroencephalography; Epilepsy, Tonic-Clonic; Evoke | 2001 |
Low cerebrospinal fluid gamma-aminobutyric acid content in seizure patients.
Topics: Adult; Epilepsy; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Clonic; Female; gamma-Aminobutyric Acid; H | 1979 |
Cerebrospinal fluid gamma-aminobutyric acid in neurologic disease.
Topics: Aminobutyrates; Cerebrovascular Disorders; Dementia; Epilepsy, Post-Traumatic; Epilepsy, Temporal Lo | 1976 |
Cerebrospinal fluid GABA reductions in seizure patients evoked by cerebellar surface stimulation.
Topics: Aminobutyrates; Cerebellar Cortex; Cyclic GMP; Electric Stimulation Therapy; Epilepsy; Epilepsy, Ton | 1977 |
Neuroethological evaluation of audiogenic seizures and audiogenic-like seizures induced by microinjection of bicuculline into the inferior colliculus. II. Effects of nigral clobazam microinjections.
Topics: Acoustic Stimulation; Animals; Anti-Anxiety Agents; Anticonvulsants; Arousal; Behavior, Animal; Benz | 1992 |
Neuroethological evaluation of audiogenic seizures and audiogenic-like seizures induced by microinjection of bicuculline into the inferior colliculus. I. Effects of midcollicular knife cuts.
Topics: Acoustic Stimulation; Animals; Arousal; Behavior, Animal; Bicuculline; Brain Mapping; Cerebral Corte | 1992 |
Susceptibility to seizures produced by chemical convulsants and maximal electric shock in rats after electrolytic lesions into the red nucleus.
Topics: Acetylcholine; Animals; Brain Chemistry; Carbachol; Convulsants; Electroencephalography; Electroshoc | 1992 |
Biochemical and behavioral studies following subchronic administration of GABA uptake inhibitors in mice.
Topics: Animals; Anticonvulsants; Catalepsy; Epilepsy, Tonic-Clonic; gamma-Aminobutyric Acid; Male; Mice; Mi | 1991 |
[Decrease of plasma prolactin in valproate therapy--expression of an increase in the activity of the central GABAergic system].
Topics: Adolescent; Brain; Child; Child, Preschool; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Female; gamma | 1987 |
Low levels of gamma-aminobutyric acid in cerebrospinal fluid of dogs with epilepsy.
Topics: Animals; Dogs; Epilepsy, Tonic-Clonic; Female; gamma-Aminobutyric Acid; Male; Phenobarbital; Primido | 1986 |