gamma-aminobutyric acid has been researched along with Constriction, Pathological in 15 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Topical application of gabapentin gel ipsilaterally but not contralaterally alleviated CCI-induced static- (days 10-30) and dynamic-allodynia (days 15-30), suppressed cold-allodynia (days 10-30), heat- (days 15-30) and mechano-hyperalgesia (days 5-30) indicating a local action." | 7.85 | Topical gabapentin gel alleviates allodynia and hyperalgesia in the chronic sciatic nerve constriction injury neuropathic pain model. ( Ahmad, N; Akbar, S; Ali, G; Fawad, K; Sewell, RD; Shahid, M; Subhan, F, 2017) |
| "Haloperidol (HAL) is a compound that shows a high affinity with these receptors, acting as an antagonist." | 5.46 | Haloperidol Decreases Hyperalgesia and Allodynia Induced by Chronic Constriction Injury. ( Espinosa-Juárez, JV; Jaramillo-Morales, OA; López-Muñoz, FJ, 2017) |
| "Neuropathic pain has proven to be a difficult condition to treat, so investigational therapy has been sought that may prove useful, such as the use of sigma-1 antagonists." | 5.46 | Haloperidol Decreases Hyperalgesia and Allodynia Induced by Chronic Constriction Injury. ( Espinosa-Juárez, JV; Jaramillo-Morales, OA; López-Muñoz, FJ, 2017) |
| "Gabapentin gel (10% w/w) was applied three times daily on the ipsilateral or contralateral plantar surface of the hind-paw, whereas in a concurrent systemic study, gabapentin was intraperitoneally administered daily (75 mg/kg) for 30 days." | 5.46 | Topical gabapentin gel alleviates allodynia and hyperalgesia in the chronic sciatic nerve constriction injury neuropathic pain model. ( Ahmad, N; Akbar, S; Ali, G; Fawad, K; Sewell, RD; Shahid, M; Subhan, F, 2017) |
| "Tests for static- and dynamic-mechano-allodynia [paw withdrawal threshold (PWT) to von Frey filament application and latency (PWL) to light brushing], cold-allodynia [paw withdrawal duration (PWD) to acetone], heat- (PWL and PWD) and mechano-hyperalgesia (PWD to pin prick) were utilized to assess pain, whereas effects on locomotion (open field) and motor balance (rotarod and footprint analysis) were measured on days 5-30 post surgery." | 5.46 | Topical gabapentin gel alleviates allodynia and hyperalgesia in the chronic sciatic nerve constriction injury neuropathic pain model. ( Ahmad, N; Akbar, S; Ali, G; Fawad, K; Sewell, RD; Shahid, M; Subhan, F, 2017) |
| "Systemic gabapentin neuropathic pain management carries side-effects ostensibly preventable by localized therapy." | 5.46 | Topical gabapentin gel alleviates allodynia and hyperalgesia in the chronic sciatic nerve constriction injury neuropathic pain model. ( Ahmad, N; Akbar, S; Ali, G; Fawad, K; Sewell, RD; Shahid, M; Subhan, F, 2017) |
| "Ambroxol's effects were compared with those of gabapentin." | 5.33 | Ambroxol, a Nav1.8-preferring Na(+) channel blocker, effectively suppresses pain symptoms in animal models of chronic, neuropathic and inflammatory pain. ( Arndt, K; Gaida, W; Klinder, K; Weiser, T, 2005) |
| "Neuropathic pain affects many patients, and treatment today is far from being perfect." | 5.33 | Ambroxol, a Nav1.8-preferring Na(+) channel blocker, effectively suppresses pain symptoms in animal models of chronic, neuropathic and inflammatory pain. ( Arndt, K; Gaida, W; Klinder, K; Weiser, T, 2005) |
| "Neuropathic pain is a debilitating condition affecting millions of people around the world and is defined as pain that follows a lesion or dysfunction of the nervous system." | 5.33 | Identification of the alpha2-delta-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin. ( Bramwell, S; Corradini, L; Cox, PJ; Dolphin, AC; England, S; Field, MJ; Hendrich, J; Kinloch, RA; Melrose, H; Offord, J; Stott, E; Su, TZ; Webb, T; Williams, D; Winks, J, 2006) |
| "Topical application of gabapentin gel ipsilaterally but not contralaterally alleviated CCI-induced static- (days 10-30) and dynamic-allodynia (days 15-30), suppressed cold-allodynia (days 10-30), heat- (days 15-30) and mechano-hyperalgesia (days 5-30) indicating a local action." | 3.85 | Topical gabapentin gel alleviates allodynia and hyperalgesia in the chronic sciatic nerve constriction injury neuropathic pain model. ( Ahmad, N; Akbar, S; Ali, G; Fawad, K; Sewell, RD; Shahid, M; Subhan, F, 2017) |
| " In vivo microdialysis was performed in parallel in awake, freely moving rats in order to evaluate possible alterations in extracellular gamma-aminobutyric acid (GABA) levels in a pain-modulating region, the medial thalamus." | 3.70 | Tiagabine antinociception in rodents depends on GABA(B) receptor activation: parallel antinociception testing and medial thalamus GABA microdialysis. ( Bartolini, A; Ipponi, A; Lamberti, C; Malmberg-Aiello, P; Medica, A, 1999) |
| "Haloperidol (HAL) is a compound that shows a high affinity with these receptors, acting as an antagonist." | 1.46 | Haloperidol Decreases Hyperalgesia and Allodynia Induced by Chronic Constriction Injury. ( Espinosa-Juárez, JV; Jaramillo-Morales, OA; López-Muñoz, FJ, 2017) |
| "Neuropathic pain has proven to be a difficult condition to treat, so investigational therapy has been sought that may prove useful, such as the use of sigma-1 antagonists." | 1.46 | Haloperidol Decreases Hyperalgesia and Allodynia Induced by Chronic Constriction Injury. ( Espinosa-Juárez, JV; Jaramillo-Morales, OA; López-Muñoz, FJ, 2017) |
| "Gabapentin gel (10% w/w) was applied three times daily on the ipsilateral or contralateral plantar surface of the hind-paw, whereas in a concurrent systemic study, gabapentin was intraperitoneally administered daily (75 mg/kg) for 30 days." | 1.46 | Topical gabapentin gel alleviates allodynia and hyperalgesia in the chronic sciatic nerve constriction injury neuropathic pain model. ( Ahmad, N; Akbar, S; Ali, G; Fawad, K; Sewell, RD; Shahid, M; Subhan, F, 2017) |
| "Tests for static- and dynamic-mechano-allodynia [paw withdrawal threshold (PWT) to von Frey filament application and latency (PWL) to light brushing], cold-allodynia [paw withdrawal duration (PWD) to acetone], heat- (PWL and PWD) and mechano-hyperalgesia (PWD to pin prick) were utilized to assess pain, whereas effects on locomotion (open field) and motor balance (rotarod and footprint analysis) were measured on days 5-30 post surgery." | 1.46 | Topical gabapentin gel alleviates allodynia and hyperalgesia in the chronic sciatic nerve constriction injury neuropathic pain model. ( Ahmad, N; Akbar, S; Ali, G; Fawad, K; Sewell, RD; Shahid, M; Subhan, F, 2017) |
| "Systemic gabapentin neuropathic pain management carries side-effects ostensibly preventable by localized therapy." | 1.46 | Topical gabapentin gel alleviates allodynia and hyperalgesia in the chronic sciatic nerve constriction injury neuropathic pain model. ( Ahmad, N; Akbar, S; Ali, G; Fawad, K; Sewell, RD; Shahid, M; Subhan, F, 2017) |
| "Using 3 rat models of neuropathic pain of toxic (oxaliplatin/OXA), metabolic (streptozocin/STZ), and traumatic (sciatic nerve ligation/CCI [chronic constriction nerve injury]) etiologies, we investigated the antihypersensitivity effect of acute and repeated agomelatine administration." | 1.46 | Agomelatine: a new opportunity to reduce neuropathic pain-preclinical evidence. ( Authier, N; Bertrand, M; Chapuy, E; Chenaf, C; Courteix, C; Eschalier, A; Gabriel, C; Libert, F; Marchand, F; Mocaër, E, 2017) |
| "Gabapentin (GBP) is an anti-convulsive drug often used as analgesic to control neuropathic pain." | 1.42 | Gabapentin attenuates neuropathic pain and improves nerve myelination after chronic sciatic constriction in rats. ( Araújo, CV; Brito, GAC; Câmara, CC; de Sousa, KKO; Martinez, AMB; Mendonça, FE; Mietto, BS; Oriá, RB; Raposo, RDS; Vale, ML, 2015) |
| "Gabapentin (GBP) is an anti-convulsive drug often used as analgesic to control neuropathic pain." | 1.39 | Oral gabapentin treatment accentuates nerve and peripheral inflammatory responses following experimental nerve constriction in Wistar rats. ( Araújo, CV; Barbosa, AL; Brito, GA; Câmara, CC; Costa, CM; da Silva, AP; Gomes, AS; Oriá, RB; Ramos, HF; Ribeiro, RA; Vale, ML, 2013) |
| "Ambroxol's effects were compared with those of gabapentin." | 1.33 | Ambroxol, a Nav1.8-preferring Na(+) channel blocker, effectively suppresses pain symptoms in animal models of chronic, neuropathic and inflammatory pain. ( Arndt, K; Gaida, W; Klinder, K; Weiser, T, 2005) |
| "Neuropathic pain affects many patients, and treatment today is far from being perfect." | 1.33 | Ambroxol, a Nav1.8-preferring Na(+) channel blocker, effectively suppresses pain symptoms in animal models of chronic, neuropathic and inflammatory pain. ( Arndt, K; Gaida, W; Klinder, K; Weiser, T, 2005) |
| "Neuropathic pain is a debilitating condition affecting millions of people around the world and is defined as pain that follows a lesion or dysfunction of the nervous system." | 1.33 | Identification of the alpha2-delta-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin. ( Bramwell, S; Corradini, L; Cox, PJ; Dolphin, AC; England, S; Field, MJ; Hendrich, J; Kinloch, RA; Melrose, H; Offord, J; Stott, E; Su, TZ; Webb, T; Williams, D; Winks, J, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.67) | 18.7374 |
| 1990's | 2 (13.33) | 18.2507 |
| 2000's | 5 (33.33) | 29.6817 |
| 2010's | 7 (46.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Espinosa-Juárez, JV | 1 |
| Jaramillo-Morales, OA | 1 |
| López-Muñoz, FJ | 1 |
| Hopkins, SC | 1 |
| Zhao, FY | 1 |
| Bowen, CA | 1 |
| Fang, X | 1 |
| Wei, H | 1 |
| Heffernan, ML | 1 |
| Spear, KL | 1 |
| Spanswick, DC | 1 |
| Varney, MA | 1 |
| Large, TH | 1 |
| Câmara, CC | 2 |
| Ramos, HF | 1 |
| da Silva, AP | 1 |
| Araújo, CV | 2 |
| Gomes, AS | 1 |
| Vale, ML | 2 |
| Barbosa, AL | 1 |
| Ribeiro, RA | 1 |
| Brito, GA | 1 |
| Costa, CM | 1 |
| Oriá, RB | 2 |
| de Sousa, KKO | 1 |
| Brito, GAC | 1 |
| Raposo, RDS | 1 |
| Mendonça, FE | 1 |
| Mietto, BS | 1 |
| Martinez, AMB | 1 |
| Shahid, M | 1 |
| Subhan, F | 1 |
| Ahmad, N | 1 |
| Ali, G | 1 |
| Akbar, S | 1 |
| Fawad, K | 1 |
| Sewell, RD | 1 |
| Chenaf, C | 1 |
| Chapuy, E | 1 |
| Libert, F | 1 |
| Marchand, F | 1 |
| Courteix, C | 1 |
| Bertrand, M | 1 |
| Gabriel, C | 1 |
| Mocaër, E | 1 |
| Eschalier, A | 1 |
| Authier, N | 1 |
| Muthuraman, A | 1 |
| Singh, N | 1 |
| Gaida, W | 1 |
| Klinder, K | 1 |
| Arndt, K | 1 |
| Weiser, T | 1 |
| Field, MJ | 1 |
| Cox, PJ | 1 |
| Stott, E | 1 |
| Melrose, H | 1 |
| Offord, J | 1 |
| Su, TZ | 1 |
| Bramwell, S | 1 |
| Corradini, L | 1 |
| England, S | 1 |
| Winks, J | 1 |
| Kinloch, RA | 1 |
| Hendrich, J | 1 |
| Dolphin, AC | 1 |
| Webb, T | 1 |
| Williams, D | 1 |
| Tanimoto-Mori, S | 1 |
| Nakazato-Imasato, E | 1 |
| Toide, K | 1 |
| Kita, Y | 1 |
| Skolnick, AA | 1 |
| Manack, L | 1 |
| Ipponi, A | 1 |
| Lamberti, C | 1 |
| Medica, A | 1 |
| Bartolini, A | 1 |
| Malmberg-Aiello, P | 1 |
| Galenko-Iaroshevskiĭ, PA | 1 |
| Uvarov, AV | 1 |
| Linchenko, SN | 1 |
| Popkov, VL | 1 |
| Sheĭkh-Zade, IuR | 1 |
| Cherednik, IL | 1 |
| Silva, JA | 1 |
| Taricco, MA | 1 |
| Brito, JC | 1 |
| Neves, VD | 1 |
| Farias, RL | 1 |
| Egawa, M | 1 |
| Hashimoto, N | 1 |
| Tobe, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Ambroxol on the Inflammatory Markers and Clinical Outcome of Patients With Diabetic Peripheral Neuropathy[NCT05558878] | 80 participants (Anticipated) | Interventional | 2022-10-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
15 other studies available for gamma-aminobutyric acid and Constriction, Pathological
| Article | Year |
|---|---|
Haloperidol Decreases Hyperalgesia and Allodynia Induced by Chronic Constriction Injury.
Topics: Amines; Analgesics; Animals; Antipsychotic Agents; Chronic Disease; Constriction, Pathologic; Cycloh | 2017 |
Pharmacodynamic effects of a D-amino acid oxidase inhibitor indicate a spinal site of action in rat models of neuropathic pain.
Topics: Amines; Analgesics; Anesthesia; Animals; Behavior, Animal; Constriction, Pathologic; Cyclohexanecarb | 2013 |
Oral gabapentin treatment accentuates nerve and peripheral inflammatory responses following experimental nerve constriction in Wistar rats.
Topics: Administration, Oral; Amines; Analgesics; Animals; Cell Movement; Constriction, Pathologic; Cyclohex | 2013 |
Gabapentin attenuates neuropathic pain and improves nerve myelination after chronic sciatic constriction in rats.
Topics: Amines; Animals; Anticonvulsants; Constriction, Pathologic; Cyclohexanecarboxylic Acids; Gabapentin; | 2015 |
Topical gabapentin gel alleviates allodynia and hyperalgesia in the chronic sciatic nerve constriction injury neuropathic pain model.
Topics: Administration, Topical; Amines; Analgesics; Animals; Constriction, Pathologic; Cyclohexanecarboxyli | 2017 |
Agomelatine: a new opportunity to reduce neuropathic pain-preclinical evidence.
Topics: Acetamides; Adrenergic alpha-2 Receptor Antagonists; Amines; Animals; Antineoplastic Agents; Constri | 2017 |
Attenuating effect of Acorus calamus extract in chronic constriction injury induced neuropathic pain in rats: an evidence of anti-oxidative, anti-inflammatory, neuroprotective and calcium inhibitory effects.
Topics: Acorus; Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Behavior, Animal; Calcium; Cons | 2011 |
Ambroxol, a Nav1.8-preferring Na(+) channel blocker, effectively suppresses pain symptoms in animal models of chronic, neuropathic and inflammatory pain.
Topics: Ambroxol; Amines; Analgesics; Animals; Behavior, Animal; Constriction, Pathologic; Cyclohexanecarbox | 2005 |
Identification of the alpha2-delta-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin.
Topics: Amino Acid Sequence; Analgesics; Animals; Arginine; Autoradiography; Base Sequence; Calcium Channels | 2006 |
Pharmacologic investigation of the mechanism underlying cold allodynia using a new cold plate procedure in rats with chronic constriction injuries.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Calcium Channel Blockers; Chronic Disease; Cold Tempe | 2008 |
Science reporters hear wide range of recent data at 12th annual conference.
Topics: Acetates; Aged; AIDS Vaccines; American Medical Association; Amines; Animals; Anticonvulsants; beta- | 1993 |
Tiagabine antinociception in rodents depends on GABA(B) receptor activation: parallel antinociception testing and medial thalamus GABA microdialysis.
Topics: Abdomen; Animals; Baclofen; Constriction, Pathologic; Dose-Response Relationship, Drug; Escape React | 1999 |
[Effect of the gamma-aminobutyric acid derivative TZ-50-2 on the autonomic nervous system].
Topics: Acetylcholine; Adrenal Glands; Alkaloids; Animals; Anti-Arrhythmia Agents; Anticonvulsants; Autonomi | 2000 |
[Constrictive arachnoiditis after pantopaque myelography causing syringomyelia and paraparesis: case report].
Topics: Acetates; Amines; Analgesics; Arachnoid Cysts; Arachnoiditis; Constriction, Pathologic; Contrast Med | 2001 |
[Effect of MCI-2016 (bifemelane hydrochloride) on cerebral ischemia following ligation of both common carotid arteries in Mongolian gerbils].
Topics: Administration, Oral; Age Factors; Animals; Benzhydryl Compounds; Brain Ischemia; Carotid Artery Dis | 1985 |