gamma-aminobutyric acid has been researched along with Congenital Stiff-Man Syndrome in 58 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients with stiff-person syndrome (SPS) have circulating antibodies against glutamic acid decarboxylase, the rate-limiting enzyme responsible for the synthesis of gamma-aminobutyric acid (GABA)." | 7.73 | Brain gamma-aminobutyric acid changes in stiff-person syndrome. ( Dalakas, MC; Fujii, M; Levy, LM; Levy-Reis, I, 2005) |
| "We re-investigated a 53 year old woman with SPS and profound anxiety for GABA-A receptor binding in the amygdala with (11)C-flumazenil PET scan and studied the potential pathogenic role of purified IgG from her plasma filtrates containing high-titer antibodies against GAD 65." | 3.77 | Human stiff-person syndrome IgG induces anxious behavior in rats. ( Dirkx, R; Folli, F; Geis, C; Gerlach, M; Grünewald, B; Heckmann, M; Perani, D; Reif, A; Solimena, M; Sommer, C; Toyka, KV; Weishaupt, A; Wultsch, T, 2011) |
| "Patients with stiff-person syndrome (SPS) have circulating antibodies against glutamic acid decarboxylase, the rate-limiting enzyme responsible for the synthesis of gamma-aminobutyric acid (GABA)." | 3.73 | Brain gamma-aminobutyric acid changes in stiff-person syndrome. ( Dalakas, MC; Fujii, M; Levy, LM; Levy-Reis, I, 2005) |
| "Glutamic acid decarboxylase (GAD), the enzyme responsible for converting glutamate to gamma-aminobutyric acid (GABA), is a target of humoral autoimmunity in stiff-man syndrome and subacute cerebellar ataxia." | 3.70 | Presynaptic impairment of cerebellar inhibitory synapses by an autoantibody to glutamate decarboxylase. ( Ishida, K; Kobayashi, T; Mitoma, H; Mizusawa, H; Song, SY; Yamakuni, T, 2000) |
| "Gamma-aminobutyric acid is a major inhibitory neurotransmitter in the central nervous system." | 2.44 | [Gamma-aminobutyric acid--metabolism and its disorders]. ( Kowalski, A; Rebas, E; Zylińska, L, 2007) |
| "It is characterized by muscle spasms triggered by startle, voluntary movement, or tactile or emotional stimuli, occurring predominantly in the axial musculature." | 1.37 | Stiff person syndrome and pregnancy. ( Blaskiewicz, R; Goldkamp, J; Myles, T, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 15 (25.86) | 18.2507 |
| 2000's | 23 (39.66) | 29.6817 |
| 2010's | 18 (31.03) | 24.3611 |
| 2020's | 2 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Dalakas, MC | 7 |
| Taneda, T | 1 |
| Okawara, S | 1 |
| Namekawa, M | 1 |
| Umeda, Y | 1 |
| Oyake, M | 1 |
| Fujita, N | 1 |
| Baizabal-Carvallo, JF | 1 |
| Dayalu, P | 1 |
| Teener, JW | 1 |
| Nakane, S | 1 |
| Fujita, K | 1 |
| Shibuta, Y | 1 |
| Matsui, N | 1 |
| Harada, M | 1 |
| Urushihara, R | 1 |
| Nishida, Y | 1 |
| Izumi, Y | 1 |
| Kaji, R | 1 |
| Chang, T | 3 |
| Alexopoulos, H | 3 |
| McMenamin, M | 2 |
| Carvajal-González, A | 1 |
| Alexander, SK | 1 |
| Deacon, R | 2 |
| Erdelyi, F | 2 |
| Szabó, G | 2 |
| Gabor, S | 1 |
| Lang, B | 2 |
| Blaes, F | 1 |
| Brown, P | 2 |
| Vincent, A | 2 |
| Schaefer, N | 1 |
| Langlhofer, G | 1 |
| Kluck, CJ | 1 |
| Villmann, C | 1 |
| Pettingill, P | 1 |
| Buckley, CJ | 1 |
| Marín, T | 1 |
| Hernando, D | 1 |
| Kinast, N | 1 |
| Churruca, I | 1 |
| Sabate, S | 1 |
| Oskarsson, B | 1 |
| Pelak, V | 1 |
| Quan, D | 1 |
| Hall, D | 1 |
| Foster, C | 1 |
| Galetta, S | 1 |
| Evoli, A | 1 |
| Cerimagic, D | 1 |
| Bilic, E | 1 |
| Kowalski, A | 1 |
| Rebas, E | 1 |
| Zylińska, L | 1 |
| Culav-Sumić, J | 1 |
| Bosnjak, I | 1 |
| Pastar, Z | 1 |
| Jukić, V | 1 |
| Thümen, A | 1 |
| Moser, A | 1 |
| Geis, C | 2 |
| Weishaupt, A | 2 |
| Hallermann, S | 1 |
| Grünewald, B | 2 |
| Wessig, C | 1 |
| Wultsch, T | 2 |
| Reif, A | 2 |
| Byts, N | 1 |
| Beck, M | 1 |
| Jablonka, S | 1 |
| Boettger, MK | 1 |
| Üçeyler, N | 1 |
| Fouquet, W | 1 |
| Gerlach, M | 2 |
| Meinck, HM | 4 |
| Sirén, AL | 1 |
| Sigrist, SJ | 1 |
| Toyka, KV | 2 |
| Heckmann, M | 2 |
| Sommer, C | 2 |
| Dirkx, R | 1 |
| Solimena, M | 3 |
| Perani, D | 2 |
| Folli, F | 2 |
| Ali, F | 1 |
| Rowley, M | 1 |
| Jayakrishnan, B | 1 |
| Teuber, S | 1 |
| Gershwin, ME | 1 |
| Mackay, IR | 1 |
| Goldkamp, J | 1 |
| Blaskiewicz, R | 1 |
| Myles, T | 1 |
| Hadavi, S | 1 |
| Noyce, AJ | 1 |
| Leslie, RD | 1 |
| Giovannoni, G | 1 |
| Squintani, G | 1 |
| Bovi, T | 1 |
| Ferigo, L | 1 |
| Musso, AM | 1 |
| Ottaviani, S | 1 |
| Moretto, G | 1 |
| Morgante, F | 1 |
| Tinazzi, M | 1 |
| Rakocevic, G | 2 |
| Floeter, MK | 4 |
| Purcell, TB | 1 |
| Sellers, AD | 1 |
| Goehring, LS | 1 |
| Kim, MJ | 1 |
| Lim, YM | 1 |
| Kim, JS | 1 |
| Kim, KK | 1 |
| Sakai, K | 3 |
| Murinson, BB | 1 |
| Butler, M | 1 |
| Marfurt, K | 1 |
| Gleason, S | 1 |
| De Camilli, P | 1 |
| Ameli, R | 1 |
| Snow, J | 1 |
| Levy, LM | 2 |
| Levy-Reis, I | 1 |
| Fujii, M | 1 |
| Economides, JR | 1 |
| Horton, JC | 1 |
| Wong, VC | 1 |
| Lam, CW | 1 |
| Fung, CW | 1 |
| Garibotto, V | 1 |
| Panzacchi, A | 1 |
| Moresco, RM | 1 |
| Ortelli, P | 1 |
| Corbo, M | 1 |
| Fazio, F | 1 |
| Teggi, R | 1 |
| Piccioni, LO | 1 |
| Martino, G | 1 |
| Bellini, C | 1 |
| Bussi, M | 1 |
| Holmøy, T | 1 |
| Hattan, E | 1 |
| Angle, MR | 1 |
| Chalk, C | 1 |
| Vernino, S | 1 |
| McEvoy, K | 1 |
| Ricker, K | 1 |
| Hülser, PJ | 1 |
| Schmid, E | 1 |
| Peiffer, J | 1 |
| Dumon, V | 1 |
| Docherty, M | 1 |
| Vermeij, FH | 1 |
| van Doorn, PA | 1 |
| Busch, HF | 1 |
| Lernmark, A | 1 |
| Giometto, B | 1 |
| Miotto, D | 1 |
| Faresin, F | 1 |
| Argentiero, V | 1 |
| Scaravilli, T | 1 |
| Tavolato, B | 1 |
| Diedrich, U | 1 |
| Prevett, MC | 1 |
| Duncan, JS | 1 |
| Sharoqi, IA | 1 |
| Valls-Solé, J | 1 |
| Toro, C | 1 |
| Jacobowitz, D | 1 |
| Hallett, M | 1 |
| Dinkel, K | 1 |
| Jury, KM | 1 |
| Karges, W | 1 |
| Richter, W | 1 |
| Rehman, HU | 1 |
| Mitoma, H | 1 |
| Song, SY | 1 |
| Ishida, K | 1 |
| Yamakuni, T | 1 |
| Kobayashi, T | 1 |
| Mizusawa, H | 1 |
| Inuzuka, T | 1 |
| Sandbrink, F | 1 |
| Syed, NA | 1 |
| Fujii, MD | 1 |
| Bhutani, MS | 1 |
| Mathews, T | 1 |
| Akuthota, P | 1 |
| Brashear, HR | 1 |
| Phillips, LH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Rituximab in Patients With Stiff Person Syndrome With Anti-GAD Antibodies: A Randomized Placebo-Controlled Trial[NCT00091897] | Phase 2 | 24 participants (Actual) | Interventional | 2004-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
19 reviews available for gamma-aminobutyric acid and Congenital Stiff-Man Syndrome
| Article | Year |
|---|---|
Stiff-person Syndrome and GAD Antibody-spectrum Disorders: GABAergic Neuronal Excitability, Immunopathogenesis and Update on Antibody Therapies.
Topics: Autoantibodies; GABAergic Neurons; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Humans; Stiff-P | 2022 |
The neurological syndromes associated with glutamic acid decarboxylase antibodies.
Topics: Autoantibodies; Autoimmune Diseases; Autoimmunity; Brain; Combined Modality Therapy; Disease Suscept | 2019 |
Stiff Person syndrome and other anti-GAD-associated neurologic disorders.
Topics: Autoantibodies; Central Nervous System; Female; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hu | 2012 |
Glycine receptor mouse mutants: model systems for human hyperekplexia.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Genetic Predisposition to Disease; Glycine | 2013 |
Immunology of stiff person syndrome and other GAD-associated neurological disorders.
Topics: Animals; Autoantibodies; Autoantigens; Autoimmune Diseases of the Nervous System; Biomarkers; Diseas | 2013 |
[Anaesthetic management of Stiff Man syndrome].
Topics: Adult; Anesthesia, Inhalation; Anesthesia, Intravenous; Autoantibodies; Autoantigens; Botulinum Toxi | 2015 |
[Gamma-aminobutyric acid--metabolism and its disorders].
Topics: Anxiety Disorders; Central Nervous System Diseases; Fatigue Syndrome, Chronic; gamma-Aminobutyric Ac | 2007 |
Stiff-person syndrome (SPS) and anti-GAD-related CNS degenerations: protean additions to the autoimmune central neuropathies.
Topics: Autoantibodies; Central Nervous System; Diabetes Mellitus, Type 1; Epilepsy; GABAergic Neurons; gamm | 2011 |
Stiff person syndrome.
Topics: Diagnosis, Differential; GABA Agents; gamma-Aminobutyric Acid; Glutamate Decarboxylase; History, 20t | 2011 |
Autoimmune stiff person syndrome and related myelopathies: understanding of electrophysiological and immunological processes.
Topics: Autoantibodies; Electrophysiology; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Humans; Spinal | 2012 |
[Stiff-person syndrome].
Topics: Animals; Autoantibodies; Autoimmunity; Diabetes Mellitus, Type 1; Diagnosis, Differential; Diazepam; | 2002 |
[Stiff-Man syndrome].
Topics: Animals; Autoantibodies; Diabetes Mellitus, Type 1; Diagnosis, Differential; Diazepam; GABA Modulato | 2006 |
Stiff-person syndrome with acute recurrent peripheral vertigo: possible evidence of gamma aminobutyric acid as a neurotransmitter in the vestibular periphery.
Topics: Autoantibodies; Electromyography; GABA Agents; GABA Modulators; gamma-Aminobutyric Acid; Humans; Lor | 2008 |
Advances in the pathogenesis and treatment of patients with stiff person syndrome.
Topics: Adaptor Proteins, Signal Transducing; Apoptosis Regulatory Proteins; Autoantibodies; Autoantigens; C | 2008 |
Glutamic acid decarboxylase--gene to antigen to disease.
Topics: Animals; Autoantibodies; Autoimmune Diseases; Autoimmunity; Diabetes Mellitus; gamma-Aminobutyric Ac | 1996 |
The stiff-person syndrome: an autoimmune disorder affecting neurotransmission of gamma-aminobutyric acid.
Topics: Adjuvants, Immunologic; Autoantibodies; Brain; Diazepam; Electromyography; GABA Modulators; gamma-Am | 1999 |
[Stiff-man(person) syndrome].
Topics: Autoantibodies; Diagnosis, Differential; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Humans; N | 2000 |
[Stiff-man syndrome].
Topics: Autoantibodies; Diabetes Mellitus, Type 1; Diagnosis, Differential; Diazepam; GABA Agents; gamma-Ami | 2000 |
[Stiff-man syndrome: an immunopathy?].
Topics: Autoantibodies; Autoimmune Diseases; gamma-Aminobutyric Acid; Glutamate Dehydrogenase; Humans; Neuro | 1991 |
39 other studies available for gamma-aminobutyric acid and Congenital Stiff-Man Syndrome
| Article | Year |
|---|---|
[Isolated ACTH deficiency clinically presented as stiff-person syndrome, successfully treated by hormonal replacement: a case report].
Topics: Adrenocorticotropic Hormone; Aged; Aminobutyrates; Autoantibodies; Contracture; Endocrine System Dis | 2022 |
Successful treatment of stiff person syndrome with sequential use of tacrolimus.
Topics: Aged; Autoantibodies; Brain; Dose-Response Relationship, Drug; Drug Administration Schedule; Evoked | 2013 |
Neuronal surface and glutamic acid decarboxylase autoantibodies in Nonparaneoplastic stiff person syndrome.
Topics: Adult; Aged; Aged, 80 and over; Animals; Autoantibodies; Cohort Studies; Female; GABAergic Neurons; | 2013 |
Immunization against GAD induces antibody binding to GAD-independent antigens and brainstem GABAergic neuronal loss.
Topics: Animals; Autoantibodies; Autoimmunity; Cells, Cultured; Cerebellum; Female; GABAergic Neurons; gamma | 2013 |
Stiff eyes in stiff-person syndrome.
Topics: Autoantibodies; Diagnosis, Differential; Disease Progression; Electromyography; Female; gamma-Aminob | 2008 |
Antibody-phenotype correlation in stiff-person syndrome.
Topics: Autoantibodies; Biomarkers; Breast Neoplasms; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Huma | 2008 |
Stiff-person syndrome first manifesting in pregnancy.
Topics: Adult; Autoantibodies; Autoimmune Diseases; Cesarean Section; Electromyography; Female; Follow-Up St | 2009 |
Anxious depression and the stiff-person plus syndrome.
Topics: Anti-Inflammatory Agents; Antidepressive Agents; Antimanic Agents; Antipsychotic Agents; Anxiety; Au | 2008 |
An uncommon paraneoplastic Ri-positive opsoclonus-myoclonus-like syndrome and stiff-person syndrome with elevated glutamate/GABA ratio in the cerebrospinal fluid after breast cancer.
Topics: Antigens, Neoplasm; Autoantibodies; Breast Neoplasms; Disease Progression; Female; gamma-Aminobutyri | 2010 |
Stiff person syndrome-associated autoantibodies to amphiphysin mediate reduced GABAergic inhibition.
Topics: Aged; Animals; Autoantibodies; Cells, Cultured; Endocytosis; Female; gamma-Aminobutyric Acid; Humans | 2010 |
Human stiff-person syndrome IgG induces anxious behavior in rats.
Topics: Adult; Amygdala; Animals; Anxiety; Behavior, Animal; Carbon Radioisotopes; Cells, Cultured; Female; | 2011 |
Stiff person syndrome and pregnancy.
Topics: Adult; Amines; Baclofen; Cesarean Section; Cyclohexanecarboxylic Acids; Diazepam; Female; Gabapentin | 2011 |
Efficacy of pregabalin in a case of stiff-person syndrome: clinical and neurophysiological evidence.
Topics: Aged; Analgesics; Back Pain; Electroencephalography; Electromyography; Female; gamma-Aminobutyric Ac | 2012 |
Presumed case of "stiff-horse syndrome" caused by decreased gamma-aminobutyric acid (GABA) production in an American Paint mare.
Topics: Animals; Autoantibodies; Dexamethasone; Electromyography; Female; gamma-Aminobutyric Acid; Glucocort | 2012 |
GABAergic changes in (11)C-flumazenil PET in the drug-naïve Stiff-Person syndrome.
Topics: Adult; Carbon Radioisotopes; Female; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Glutamate | 2013 |
GAD antibodies in stiff-person syndrome.
Topics: Autoantibodies; Autoantigens; Autoimmune Diseases; Cohort Studies; gamma-Aminobutyric Acid; Glutamat | 2004 |
Markedly elevated GAD antibodies in SPS: effects of age and illness duration.
Topics: Age Factors; Antibody Specificity; Autoantibodies; Autoantigens; Autoimmune Diseases; Blotting, West | 2004 |
A neuropsychological assessment of phobias in patients with stiff person syndrome.
Topics: Accidental Falls; Adult; Anxiety Disorders; Brain; Brain Chemistry; Cognition Disorders; Female; gam | 2005 |
Brain gamma-aminobutyric acid changes in stiff-person syndrome.
Topics: Adult; Brain; Case-Control Studies; Female; gamma-Aminobutyric Acid; Humans; Magnetic Resonance Imag | 2005 |
Eye movement abnormalities in stiff person syndrome.
Topics: Adult; Atrophy; Brain Stem; Cerebellar Diseases; Cerebellum; Female; gamma-Aminobutyric Acid; Glutam | 2005 |
Stiff child syndrome with mutation of DYT1 gene.
Topics: Asian People; Autoantibodies; Child; Disease Progression; DNA Mutational Analysis; Dystonia; GABA Ag | 2005 |
PET evidence of central GABAergic changes in stiff-person syndrome.
Topics: Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Neuropsychological Tests; Positron-Emiss | 2007 |
Long-term effect of gabapentin in stiff limb syndrome: a case report.
Topics: Adult; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyric | 2007 |
Unexpected benefit of propofol in stiff-person syndrome.
Topics: Aged; Autoantibodies; Baclofen; Diazepam; Drug Resistance; Female; GABA Agonists; GABA-A Receptor Ag | 2008 |
Propofol for stiff-person syndrome: learning new tricks from an old dog.
Topics: Aged; Autoantibodies; Baclofen; Diazepam; Drug Resistance; Female; GABA Agonists; GABA-A Receptor Ag | 2008 |
Stiff man syndrome: clinical and laboratory findings in eight patients.
Topics: Adult; Aged; Autoantibodies; Autoimmune Diseases; Baclofen; Benzodiazepines; Blood Proteins; Central | 1994 |
Investigation of a novel GABAergic cell-surface marker which may link Stiff Man's syndrome and insulin-dependent diabetes mellitus.
Topics: Animals; Autoantigens; Biomarkers; Cells, Cultured; Cerebellum; Diabetes Mellitus, Type 1; gamma-Ami | 1993 |
Improvement of stiff-man syndrome with vigabatrin.
Topics: Adult; Anticonvulsants; gamma-Aminobutyric Acid; Humans; Male; Stiff-Person Syndrome; Vigabatrin | 1996 |
Anti-gabaergic neuron autoantibodies in a patient with stiff-man syndrome and ataxia.
Topics: Animals; Ataxia; Autoantibodies; Cerebellum; Female; gamma-Aminobutyric Acid; Humans; Immunoblotting | 1996 |
[Rhythmic circulatory dysregulation in stiff man syndrome].
Topics: Autonomic Nervous System; Baclofen; Blood Pressure; Cardiovascular System; Female; GABA Agonists; ga | 1996 |
Improvement of stiff-man syndrome with vigabatrin.
Topics: Adult; Anticonvulsants; Carbamazepine; Clonazepam; Drug Therapy, Combination; Female; gamma-Aminobut | 1997 |
Improvement of stiff-man syndrome with vigabatrin.
Topics: Aged; Anticonvulsants; gamma-Aminobutyric Acid; Humans; Male; Stiff-Person Syndrome; Vigabatrin | 1998 |
Physiologic studies of spinal inhibitory circuits in patients with stiff-person syndrome.
Topics: Adult; Aged; Electromyography; Femoral Nerve; gamma-Aminobutyric Acid; Glycine; H-Reflex; Humans; In | 1998 |
Inhibition of gamma-aminobutyric acid synthesis by glutamic acid decarboxylase autoantibodies in stiff-man syndrome.
Topics: Adult; Aged; Aged, 80 and over; Animals; Autoantibodies; Autoimmune Diseases; Cerebellum; Female; GA | 1998 |
Stiff-man syndrome.
Topics: Autoantibodies; Autoimmune Diseases; gamma-Aminobutyric Acid; Humans; Stiff-Person Syndrome | 1998 |
Presynaptic impairment of cerebellar inhibitory synapses by an autoantibody to glutamate decarboxylase.
Topics: Action Potentials; Aged; Animals; Autoantibodies; Bicuculline; Calbindins; Calcium; Calcium-Binding | 2000 |
Motor cortex excitability in stiff-person syndrome.
Topics: Action Potentials; Adult; Electric Stimulation; Evoked Potentials, Motor; Female; gamma-Aminobutyric | 2000 |
Muscle spasms and stiffness that progressed for four years.
Topics: Administration, Oral; Adult; Autoantibodies; Diagnosis, Differential; Diazepam; Electroencephalograp | 1992 |
Autoantibodies to GABAergic neurons and response to plasmapheresis in stiff-man syndrome.
Topics: Adult; Autoantibodies; Brain; Female; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Humans; Neur | 1991 |