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gamma-aminobutyric acid and Complication, Postoperative

gamma-aminobutyric acid has been researched along with Complication, Postoperative in 37 studies

gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.

Research Excerpts

ExcerptRelevanceReference
"Although postoperative opioid use was reduced, perioperative administration of gabapentin did not result in a reduction of postoperative delirium or hospital length of stay."9.24Perioperative Gabapentin Does Not Reduce Postoperative Delirium in Older Surgical Patients: A Randomized Clinical Trial. ( Ames, C; Berven, S; Bozic, K; Burch, S; Chang, S; Chen, N; Chou, D; Covinsky, K; Deviren, V; Kinjo, S; Kramer, JH; Leung, JM; Meckler, G; Newman, S; Ries, M; Sands, LP; Tay, B; Tsai, T; Vail, T; Voss, V; Weinstein, P; Youngblom, E, 2017)
"Adolescent patients undergoing idiopathic scoliosis surgery were randomized to receive a single preoperative dose of gabapentin 600 mg or placebo."9.19Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial. ( Campbell, F; Mayell, A; Peliowski, A; Srinivasan, I, 2014)
"A single preoperative dose of gabapentin did not show a significant difference in opioid consumption or pain scores in adolescents undergoing idiopathic scoliosis surgery."9.19Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial. ( Campbell, F; Mayell, A; Peliowski, A; Srinivasan, I, 2014)
" Pre-operative anxiety was significantly lower in the pregabalin group (2."9.15Effect of a single dose of pregabalin on post-operative pain and pre-operative anxiety in patients undergoing discectomy. ( Dahl, V; Raeder, J; Spreng, UJ, 2011)
" The secondary outcomes were morphine consumption, pre-operative anxiety (VAS) and the occurrence of side effects."9.15Effect of a single dose of pregabalin on post-operative pain and pre-operative anxiety in patients undergoing discectomy. ( Dahl, V; Raeder, J; Spreng, UJ, 2011)
"The VAS scores indicated that patients in the pregabalin group had significantly less shoulder pain on postoperative day (POD) 2 than those in the control group (control: 27."7.81Evaluation of postoperative pregabalin for attenuation of postoperative shoulder pain after thoracotomy in patients with lung cancer, a preliminary result. ( Goyagi, T; Horiguchi, T; Imai, K; Imai, Y; Kimura, T; Minamiya, Y; Motoyama, S; Nishikawa, T; Saito, H; Sato, Y, 2015)
"Postoperative administration of pregabalin provided significant relief of postoperative shoulder pain during earlier POD after thoracic surgery for lung cancer when received multimodal analgesia in combination with NSAIDs."7.81Evaluation of postoperative pregabalin for attenuation of postoperative shoulder pain after thoracotomy in patients with lung cancer, a preliminary result. ( Goyagi, T; Horiguchi, T; Imai, K; Imai, Y; Kimura, T; Minamiya, Y; Motoyama, S; Nishikawa, T; Saito, H; Sato, Y, 2015)
"Gabapentin was shown to be opioid sparing, with lower doses for the intervention group versus the control group."6.84Perioperative Gabapentin Does Not Reduce Postoperative Delirium in Older Surgical Patients: A Randomized Clinical Trial. ( Ames, C; Berven, S; Bozic, K; Burch, S; Chang, S; Chen, N; Chou, D; Covinsky, K; Deviren, V; Kinjo, S; Kramer, JH; Leung, JM; Meckler, G; Newman, S; Ries, M; Sands, LP; Tay, B; Tsai, T; Vail, T; Voss, V; Weinstein, P; Youngblom, E, 2017)
"Gabapentin has antihyperalgesic and potential anxiolytic effects."6.77Effects of a single 1200-mg preoperative dose of gabapentin on anxiety and memory. ( Adam, F; Bordenave, L; Chauvin, M; Sessler, DI, 2012)
"Delirium is a common complication in postoperative, critically ill patients."5.40The association of plasma gamma-aminobutyric acid concentration with postoperative delirium in critically ill patients. ( Egi, M; Kanazawa, T; Morita, K; Toda, Y; Yoshitaka, S, 2014)
"Epidural fibrosis is among the most common causes of FBSS, and it is often recalcitrant to treatment."5.31Using gabapentin to treat failed back surgery syndrome caused by epidural fibrosis: A report of 2 cases. ( Braverman, DL; Lenrow, DA; Slipman, CW, 2001)
"Gabapentin has an established, favorable safety profile and has been shown to be effective in various animal models and human studies of chronic neuropathic pain."5.31Using gabapentin to treat failed back surgery syndrome caused by epidural fibrosis: A report of 2 cases. ( Braverman, DL; Lenrow, DA; Slipman, CW, 2001)
"A variety of treatments for the pain were ineffective."5.30Gabapentin for treatment of neuropathic pain in a 12-year-old girl. ( McGraw, T; Stacey, BR, 1998)
"Although postoperative opioid use was reduced, perioperative administration of gabapentin did not result in a reduction of postoperative delirium or hospital length of stay."5.24Perioperative Gabapentin Does Not Reduce Postoperative Delirium in Older Surgical Patients: A Randomized Clinical Trial. ( Ames, C; Berven, S; Bozic, K; Burch, S; Chang, S; Chen, N; Chou, D; Covinsky, K; Deviren, V; Kinjo, S; Kramer, JH; Leung, JM; Meckler, G; Newman, S; Ries, M; Sands, LP; Tay, B; Tsai, T; Vail, T; Voss, V; Weinstein, P; Youngblom, E, 2017)
"Adolescent patients undergoing idiopathic scoliosis surgery were randomized to receive a single preoperative dose of gabapentin 600 mg or placebo."5.19Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial. ( Campbell, F; Mayell, A; Peliowski, A; Srinivasan, I, 2014)
"A single preoperative dose of gabapentin did not show a significant difference in opioid consumption or pain scores in adolescents undergoing idiopathic scoliosis surgery."5.19Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial. ( Campbell, F; Mayell, A; Peliowski, A; Srinivasan, I, 2014)
" Pre-operative anxiety was significantly lower in the pregabalin group (2."5.15Effect of a single dose of pregabalin on post-operative pain and pre-operative anxiety in patients undergoing discectomy. ( Dahl, V; Raeder, J; Spreng, UJ, 2011)
" The secondary outcomes were morphine consumption, pre-operative anxiety (VAS) and the occurrence of side effects."5.15Effect of a single dose of pregabalin on post-operative pain and pre-operative anxiety in patients undergoing discectomy. ( Dahl, V; Raeder, J; Spreng, UJ, 2011)
"The VAS scores indicated that patients in the pregabalin group had significantly less shoulder pain on postoperative day (POD) 2 than those in the control group (control: 27."3.81Evaluation of postoperative pregabalin for attenuation of postoperative shoulder pain after thoracotomy in patients with lung cancer, a preliminary result. ( Goyagi, T; Horiguchi, T; Imai, K; Imai, Y; Kimura, T; Minamiya, Y; Motoyama, S; Nishikawa, T; Saito, H; Sato, Y, 2015)
"Postoperative administration of pregabalin provided significant relief of postoperative shoulder pain during earlier POD after thoracic surgery for lung cancer when received multimodal analgesia in combination with NSAIDs."3.81Evaluation of postoperative pregabalin for attenuation of postoperative shoulder pain after thoracotomy in patients with lung cancer, a preliminary result. ( Goyagi, T; Horiguchi, T; Imai, K; Imai, Y; Kimura, T; Minamiya, Y; Motoyama, S; Nishikawa, T; Saito, H; Sato, Y, 2015)
"Gabapentin is an antiepileptic medication that also has been used for restless legs syndrome."3.73Gabapentin-induced myopathy in 2 patients on short daily hemodialysis. ( Lavoie, S; Lipson, J; Zimmerman, D, 2005)
"Gabapentin was shown to be opioid sparing, with lower doses for the intervention group versus the control group."2.84Perioperative Gabapentin Does Not Reduce Postoperative Delirium in Older Surgical Patients: A Randomized Clinical Trial. ( Ames, C; Berven, S; Bozic, K; Burch, S; Chang, S; Chen, N; Chou, D; Covinsky, K; Deviren, V; Kinjo, S; Kramer, JH; Leung, JM; Meckler, G; Newman, S; Ries, M; Sands, LP; Tay, B; Tsai, T; Vail, T; Voss, V; Weinstein, P; Youngblom, E, 2017)
"Gabapentin has antihyperalgesic and potential anxiolytic effects."2.77Effects of a single 1200-mg preoperative dose of gabapentin on anxiety and memory. ( Adam, F; Bordenave, L; Chauvin, M; Sessler, DI, 2012)
"Gabapentin is a gamma aminobutyric acid analogue that is known as an anticonvulsant drug."2.77Effect of gabapentin on postoperative pain and operation complications: a randomized placebo controlled trial. ( Abrishamkar, M; Ayatollahi, V; Bafghi, AT; Behdad, S; Tezerjani, MD, 2012)
"Prevention and treatment of postoperative pain and operation complications such as nausea and vomiting are most important concerns in postoperative care."2.77Effect of gabapentin on postoperative pain and operation complications: a randomized placebo controlled trial. ( Abrishamkar, M; Ayatollahi, V; Bafghi, AT; Behdad, S; Tezerjani, MD, 2012)
"Postoperative pain was assessed by a telephone interview 1 and 3 months after operation."2.76Pregabalin has an opioid-sparing effect in elderly patients after cardiac surgery: a randomized placebo-controlled trial. ( Hammarén, E; Kontinen, VK; Pesonen, A; Raivio, P; Rosenberg, PH; Suojaranta-Ylinen, R; Tarkkila, P, 2011)
"Postoperative confusion was measured with the Confusion Assessment Method for the intensive care unit (CAM-ICU)."2.76Pregabalin has an opioid-sparing effect in elderly patients after cardiac surgery: a randomized placebo-controlled trial. ( Hammarén, E; Kontinen, VK; Pesonen, A; Raivio, P; Rosenberg, PH; Suojaranta-Ylinen, R; Tarkkila, P, 2011)
"Infant delirium is an under-recognized clinical entity in neonatal intensive care, and earlier identification and treatment could minimize morbidities associated with this condition."1.46A case of infant delirium in the neonatal intensive care unit. ( Bidegain, M; Cotten, CM; Edwards, LE; Hornik, CD; Hutchison, LB; Smith, PB, 2017)
"The incidence of respiratory depression was 153 (95% confidence interval [CI], 146-161) episodes per 1000 cases."1.46Multimodal Analgesic Therapy With Gabapentin and Its Association With Postoperative Respiratory Depression. ( Cavalcante, AN; Schroeder, DR; Sprung, J; Weingarten, TN, 2017)
"Outcome measures were postsurgical pain at rest and during walking, consumption of opioids for pain rescue, knee swelling and knee range of motion, and complications."1.46Methylprednisolone reduces pain and decreases knee swelling in the first 24 h after fast-track unicompartmental knee arthroplasty. ( Hansen, TB; Munk, S; Rytter, S; Stilling, M, 2017)
"Delirium is a common complication in postoperative, critically ill patients."1.40The association of plasma gamma-aminobutyric acid concentration with postoperative delirium in critically ill patients. ( Egi, M; Kanazawa, T; Morita, K; Toda, Y; Yoshitaka, S, 2014)
"Neuropathic and/or neuralgic facial pain occurred in 50% (n = 7)."1.35The trigeminal trophic syndrome: an unusual cause of face pain, dysaesthesias, anaesthesia and skin/soft tissue lesions. ( Garza, I, 2008)
"Gabapentin appeared to be a safe, effective, and economical treatment for neuropathic pain in this horse."1.34Gabapentin for the treatment of neuropathic pain in a pregnant horse. ( Davis, JL; Elce, Y; Posner, LP, 2007)
" Treatment was continued for 6 days, during which the dosage was progressively decreased, and the mare was discharged."1.34Gabapentin for the treatment of neuropathic pain in a pregnant horse. ( Davis, JL; Elce, Y; Posner, LP, 2007)
"Following recovery from colic surgery to treat compression of the small and large intestines because of a large fetus, the mare was noticed to have signs of femoral neuropathy involving the left hind limb."1.34Gabapentin for the treatment of neuropathic pain in a pregnant horse. ( Davis, JL; Elce, Y; Posner, LP, 2007)
"Gabapentin is an antiepileptic medication that also has been used for restless legs syndrome."1.33Gabapentin-induced myopathy in 2 patients on short daily hemodialysis. ( Lavoie, S; Lipson, J; Zimmerman, D, 2005)
"The severe burning pain, deep pressure-like pain, and deep mechanical allodynia, which presented over the contralateral side to the TBI, were successfully relieved with motor cortex stimulation (MCS)."1.33Motor cortex stimulation for central pain following a traumatic brain injury. ( Choi, ES; Hong, JT; Lee, SW; Son, BC; Sung, JH, 2006)
"Gabapentin has an established, favorable safety profile and has been shown to be effective in various animal models and human studies of chronic neuropathic pain."1.31Using gabapentin to treat failed back surgery syndrome caused by epidural fibrosis: A report of 2 cases. ( Braverman, DL; Lenrow, DA; Slipman, CW, 2001)
"Epidural fibrosis is among the most common causes of FBSS, and it is often recalcitrant to treatment."1.31Using gabapentin to treat failed back surgery syndrome caused by epidural fibrosis: A report of 2 cases. ( Braverman, DL; Lenrow, DA; Slipman, CW, 2001)
"A variety of treatments for the pain were ineffective."1.30Gabapentin for treatment of neuropathic pain in a 12-year-old girl. ( McGraw, T; Stacey, BR, 1998)

Research

Studies (37)

TimeframeStudies, this research(%)All Research%
pre-19902 (5.41)18.7374
1990's2 (5.41)18.2507
2000's11 (29.73)29.6817
2010's21 (56.76)24.3611
2020's1 (2.70)2.80

Authors

AuthorsStudies
Chan, JCY1
Waddell, TK1
Yasufuku, K1
Keshavjee, S1
Donahoe, LL1
Levenbrown, Y1
Hossain, MJ1
Keith, JP1
Burr, K1
Hesek, A1
Shaffer, TH1
Yao, LL1
Cao, JR1
Lyu, CJ1
Fan, FF1
Wang, HP1
Cao, HW1
Huang, J1
Mei, LH1
He, P1
Li, Y1
Zhang, R1
Ren, M1
Liu, H1
Yang, M1
Liu, X1
Wang, Z1
Xu, C1
Guan, J1
Wei, B1
Liu, Y1
Swinkels, BM1
Ten Berg, JM1
Kelder, JC1
Vermeulen, FE1
van Boven, WJ1
de Mol, BA1
Huang, K1
Yang, X1
Ma, Y1
Sun, G1
Nitin, N1
Wickramasinghe, A1
Xiao, Y1
Kobayashi, N1
Wang, S1
Scherpelz, KP1
Yamazaki, T1
Meredith, SC1
Ishii, Y1
Phoonsawat, K1
Khachornsakkul, K1
Ratnarathorn, N1
Henry, CS1
Dungchai, W1
Zareena, B1
Khadim, A1
Jeelani, SUY1
Hussain, S1
Ali, A1
Musharraf, SG1
Zhuo, X1
Jiang, W1
Qian, G1
Chen, J1
Yu, T1
Luo, L1
Lu, L1
Chen, Y1
Yin, S1
Hong, NJ1
Gonzalez-Vicente, A1
Saez, F1
Garvin, JL1
Hede, KTC1
Christensen, BB1
Olesen, ML1
Thomsen, JS1
Foldager, CB1
Toh, WS1
Lim, SK1
Lind, MC1
Woods, LM1
Connelly, CD1
Doğan, MF1
Başak Türkmen, N1
Taşlıdere, A1
Şahin, Y1
Çiftçi, O1
Parsa, FD1
Cheng, J1
Stephan, B1
Castel, N1
Kim, L1
Murariu, D1
Parsa, AA1
Mulier, J1
Leung, JM1
Sands, LP1
Chen, N1
Ames, C1
Berven, S1
Bozic, K1
Burch, S1
Chou, D1
Covinsky, K1
Deviren, V1
Kinjo, S1
Kramer, JH1
Ries, M1
Tay, B1
Vail, T1
Weinstein, P1
Chang, S1
Meckler, G1
Newman, S1
Tsai, T1
Voss, V1
Youngblom, E1
Regan, DW1
Kashiwagi, D1
Dougan, B1
Sundsted, K1
Mauck, K1
López-López, J1
Estrugo-Devesa, A1
Jane-Salas, E1
Segura-Egea, JJ1
Chang, TI1
Salman, AE1
Camkıran, A1
Oğuz, S1
Dönmez, A1
Imai, Y1
Imai, K1
Kimura, T1
Horiguchi, T1
Goyagi, T1
Saito, H1
Sato, Y1
Motoyama, S1
Nishikawa, T1
Minamiya, Y1
Dighe, K1
Clarke, H1
McCartney, CJ1
Wong, CL1
Mayell, A1
Srinivasan, I1
Campbell, F1
Peliowski, A1
Yoshitaka, S1
Egi, M1
Kanazawa, T1
Toda, Y1
Morita, K1
Rytter, S1
Stilling, M1
Munk, S1
Hansen, TB1
Park, IJ1
Kim, G1
Ko, G1
Lee, YJ1
Hwang, SH1
Guo, R1
Jacobs, RE1
Cavalcante, AN1
Sprung, J1
Schroeder, DR1
Weingarten, TN1
Edwards, LE1
Hutchison, LB1
Hornik, CD1
Smith, PB1
Cotten, CM1
Bidegain, M1
Jacob, S1
Saha, A1
Rajabally, Y1
Garza, I1
Bang, SR1
Yu, SK1
Kim, TH1
Spreng, UJ1
Dahl, V1
Raeder, J1
Pesonen, A1
Suojaranta-Ylinen, R1
Hammarén, E1
Kontinen, VK1
Raivio, P1
Tarkkila, P1
Rosenberg, PH1
Silverman, A1
Samuels, Q1
Gikas, H1
Nawras, A1
Adam, F1
Bordenave, L1
Sessler, DI1
Chauvin, M1
Behdad, S1
Ayatollahi, V1
Bafghi, AT1
Tezerjani, MD1
Abrishamkar, M1
Penumalee, S1
Kissner, PZ1
Migdal, SD1
Guttuso, T1
Vitticore, P1
Holloway, RG1
Lipson, J1
Lavoie, S1
Zimmerman, D1
Son, BC1
Lee, SW1
Choi, ES1
Sung, JH1
Hong, JT1
Villevieille, T1
Boulland, P1
Plancade, D1
Steiner, T1
Chapus, JJ1
Lagauche, D1
Allford, MA1
Davis, JL1
Posner, LP1
Elce, Y1
Ackerman, WE1
Ahmad, M1
McGraw, T1
Stacey, BR1
Averbuch-Heller, L1
Stahl, JS1
Hlavin, ML1
Leigh, RJ1
Braverman, DL1
Slipman, CW1
Lenrow, DA1
Pezzuoli, G1
Spina, GP1
Vassanelli, P1
Knutsson, E1
Lindblom, U1
Mårtensson, A1

Clinical Trials (16)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Efficiency of Opioid-free Anesthesia (OFA) in Maxillofacial Surgery[NCT05031676]66 participants (Actual)Interventional2019-02-15Completed
Opioid-free Anesthesia With a Mixture of Dexmedetomidine-lidocaine-ketamine in Laparoscopic Cholecystectomies[NCT05089526]70 participants (Anticipated)Interventional2021-10-11Recruiting
Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies - the PATHFINDER II Study[NCT05279898]70 participants (Anticipated)Interventional2023-02-28Recruiting
Perioperative Multimodal General Anesthesia Focusing on Specific CNS Targets in Patients Undergoing Cardiac Surgeries[NCT04016740]Early Phase 122 participants (Actual)Interventional2019-08-20Completed
The Effect of a Mixture of Dexmedetomidine-lidocaine-ketamine in One Syringe Versus Opioids on Recovery Profile and Postoperative Pain After Gynecological Laparoscopic Surgery[NCT04858711]60 participants (Anticipated)Interventional2021-04-01Recruiting
Clinical Trial of Gabapentin to Decrease Postoperative Delirium and Pain in Surgical Patients[NCT00221338]Phase 3750 participants (Actual)Interventional2006-01-31Completed
Use of Gabapentin as Preanesthetic Medication in Oncologic Children Undergoing in Fast Procedures With Sevofluran[NCT03681574]Phase 4135 participants (Actual)Interventional2017-07-01Completed
Placebo Controlled, Randomized,Gabapentin as Adjuvant for Postoperative Pain in Pediatric Orthopedic Surgery[NCT03005483]Phase 440 participants (Actual)Interventional2014-01-31Completed
Efficacy of Gabapentin as Adjuvant for Postoperative Pain in Pediatric Thoracic Surgery - a Randomized Quadruple Blind Study[NCT03393702]Phase 4104 participants (Actual)Interventional2017-05-09Completed
The Effect of Preoperative Steroids Injection on Pain and Oedema After Total Knee Arthroplasty . A Double -Blinded Randomized Controlled Study.[NCT04084912]Phase 386 participants (Anticipated)Interventional2020-01-01Not yet recruiting
Efficacy of Steroids on Functional Outcomes After Musculoskeletal Injuries of the Hand[NCT05003596]Phase 2/Phase 360 participants (Anticipated)Interventional2021-09-01Not yet recruiting
Analgetic and Anxiolytic Effect of Preoperative Pregabalin in Patients Undergoing Surgery of the Vertebral Columna[NCT00353704]Phase 450 participants (Actual)Interventional2005-11-30Completed
Peri-Operative Pregabalin for Reducing opIoid Consumption AfTer Cardiac surgEry: A Randomized Trial[NCT04517110]Phase 317 participants (Actual)Interventional2021-04-09Terminated (stopped due to The COVID-19 pandemic has reduced recruitment such that the study is no longer feasible)
Comparison of Periosteal and Subcutaneous Infusions of Articaine and Bupivacaine in Treatment of Acute Pain After Sternotomy[NCT01536717]Phase 436 participants (Actual)Interventional2012-03-31Suspended
Pregabalin for the Treatment of Abdominal Pain From Adhesions: Placebo Controlled Trial[NCT00310765]Phase 418 participants (Actual)Interventional2006-03-31Terminated (stopped due to Study was terminated by the sponsor due to low accrual.)
The Use of Penile Vibratory Stimulation to Decrease Spasticity Following Spinal Cord Injury[NCT00223873]30 participants Interventional2002-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Hospital Length of Stay

(NCT00221338)
Timeframe: Typically within the first week after surgery

Interventiondays (Mean)
Gabapentin4.4
Placebo4.1

Incidence of Postoperative Delirium by Study Group

Number of subjects who developed postoperative delirium, as measured by the Confusion Assessment Method, a validated tool for assessing delirium based on DSM-III-R, on any of the first three postoperative days. (NCT00221338)
Timeframe: postoperative days 1, 2 and 3

InterventionParticipants (Count of Participants)
Gabapentin84
Placebo72

Median Postoperative Opioid Doses Across Study Follow up Period

Postoperative intravenous opioid doses converted to morphine equivalents. Median derived from total opioid doses on first, second and third postoperative days. (NCT00221338)
Timeframe: Study follow up period: postoperative days 1, 2 and 3

Interventionmorphine equivalents, mg (Median)
Gabapentin6.7
Placebo6.7

Postoperative Pain Score - Postoperative Day 1

Postoperative pain as measured by Visual Analog Pain scale (0=no pain, 10=worst pain imaginable). (NCT00221338)
Timeframe: Postoperative day 1

Interventionscore on a scale (Mean)
Gabapentin4
Placebo4

Postoperative Pain Score - Postoperative Day 2

Postoperative pain as measured by Visual Analog Pain scale (0=no pain, 10=worst pain imaginable). (NCT00221338)
Timeframe: Postoperative day 2

Interventionscore on a scale (Mean)
Gabapentin3
Placebo4

Postoperative Pain Score - Postoperative Day 3

Postoperative pain as measured by Visual Analog Pain scale (0=no pain, 10=worst pain imaginable). (NCT00221338)
Timeframe: Postoperative day 3

Interventionscore on a scale (Mean)
Gabapentin3
Placebo3

Mean VAS Pain (Visual Analogue Scale)at Rest (0-100 mm)

The visual analogue scale (VAS) was used for registration of the pain intensity at rest. The score ranges from 0-100, where 0 means no pain and 100 means maximal pain. Higher values represent a worse outcome. (NCT00353704)
Timeframe: 120 minutes after surgery

InterventionUnits on a scale (Mean)
Pregabalin11.7
Placebo22.5

Morphine (Opioid) Consumption Cumulated

"Patients were equipped with a morphine PCA (patient controlled analgesia) for 24 hours after surgery. So they could administrate morphine intravenously by pressing a button. The sum of morphine was registered as cumulated opioid consumption (milligram)" (NCT00353704)
Timeframe: 240 minutes

Interventionmg (Mean)
Pregabalin7.3
Placebo16.0

Absolute Adhesional Abdominal Pain Score Assessed at Baseline Through Week 12 in Patients Treated With Pregabalin 150-300 mg Daily Compared With Patients Given Look Alike Placebo

Patients were randomized to pregabalin or placebo 75 mg twice a day. Patients were allowed to double the dose on day 3 if adequate pain relief was not obtained. Abdominal pain reduction was measured on a Likert scale. A Likert scale assumes the intensity of pain is linear on a continuum from no pain at level 0 to severe pain at level 10. Patients were required to complete a daily dairy recording pain using the Likert 11-point numeric scale. The primary end point was a positive change in the daily pain diary of 2 points from each patient's baseline at weeks 8 after the completion of the blinded study and at week 12 during the open label portion of the study. After 7 weeks all patients are randomized to study drug pregabalin 150 to 300 mg daily for 4 additional weeks after a one week wash out with no medication. (NCT00310765)
Timeframe: Baseline and week 2 through week 12

,
Interventionunits on a scale (Mean)
baseline pain scoreweek 2week 3week 4week 5week 6week 7week 8 open label with no study medicationweek 9 open labelweek 10 open labelweek 11 open labelweek 12 open label
Patients Treated With Placebo5.85.224.644.844.323.883.924.132.212.272.231.13
Patients Treated With Pregabalin6.152.871.883.312.722.492.532.462.061.841.461.68

Improved Sleep Scores

Absolute Improvement in Sleep by assessing Mean Daily sleep interference scores as measured weekly starting at baseline and reported weekly through week 12 excluding the first week. This score is an 11 point scale the documents the pain interference in sleep in the preceding 24 hours. 0 is no interference and 10 is pain completely disrupted sleep in the previous 24 hours. During the study patients recorded a daily sleep interference score based on 11 point scale (0-10) with the higher number being the most sleep interference (NCT00310765)
Timeframe: Baseline and week 2 through week 12

,
Interventionunits on a scale (Mean)
baselineweek 2week 3week 4week 5week 6week 7week 8 open label no study medicationweek 9 open labelweek 10 open labelweek 11 open labelweek 12 open label
Placebo4.663.43.263.543.062.743.183.301.701.251.180.56
Pregabalin3.942.201.601.681.681.551.61.821.311.371.391.01

Reviews

2 reviews available for gamma-aminobutyric acid and Complication, Postoperative

ArticleYear
Update in perioperative medicine: practice changing evidence published in 2016.
    Hospital practice (1995), 2017, Volume: 45, Issue:4

    Topics: Amines; Analgesics; Anticoagulants; Antipsychotic Agents; Arthritis, Rheumatoid; Blood Transfusion;

2017
Does preoperative administration of gabapentin/pregabalin improve postoperative nasal surgery pain?
    The Laryngoscope, 2016, Volume: 126, Issue:10

    Topics: Adolescent; Adult; Amines; Analgesics; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminob

2016

Trials

10 trials available for gamma-aminobutyric acid and Complication, Postoperative

ArticleYear
Perioperative Gabapentin Does Not Reduce Postoperative Delirium in Older Surgical Patients: A Randomized Clinical Trial.
    Anesthesiology, 2017, Volume: 127, Issue:4

    Topics: Aged; Amines; Analgesics; Analgesics, Opioid; Cyclohexanecarboxylic Acids; Delirium; Double-Blind Me

2017
Gabapentin premedication for postoperative analgesia and emergence agitation after sevoflurane anesthesia in pediatric patients.
    Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish Society of Algology, 2013, Volume: 25, Issue:4

    Topics: Amines; Anesthesia, General; Anesthetics, Inhalation; Anti-Anxiety Agents; Child; Child, Preschool;

2013
Perioperative gabapentin and delirium following total knee arthroplasty: a post-hoc analysis of a double-blind randomized placebo-controlled trial.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2014, Volume: 61, Issue:12

    Topics: Aged; Amines; Analgesics; Arthroplasty, Replacement, Knee; Cyclohexanecarboxylic Acids; Delirium; Do

2014
Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial.
    Paediatric anaesthesia, 2014, Volume: 24, Issue:12

    Topics: Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Cyclohexanecarbox

2014
Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial.
    Paediatric anaesthesia, 2014, Volume: 24, Issue:12

    Topics: Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Cyclohexanecarbox

2014
Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial.
    Paediatric anaesthesia, 2014, Volume: 24, Issue:12

    Topics: Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Cyclohexanecarbox

2014
Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial.
    Paediatric anaesthesia, 2014, Volume: 24, Issue:12

    Topics: Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Cyclohexanecarbox

2014
Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial.
    Paediatric anaesthesia, 2014, Volume: 24, Issue:12

    Topics: Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Cyclohexanecarbox

2014
Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial.
    Paediatric anaesthesia, 2014, Volume: 24, Issue:12

    Topics: Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Cyclohexanecarbox

2014
Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial.
    Paediatric anaesthesia, 2014, Volume: 24, Issue:12

    Topics: Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Cyclohexanecarbox

2014
Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial.
    Paediatric anaesthesia, 2014, Volume: 24, Issue:12

    Topics: Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Cyclohexanecarbox

2014
Analgesic effects of gabapentin after scoliosis surgery in children: a randomized controlled trial.
    Paediatric anaesthesia, 2014, Volume: 24, Issue:12

    Topics: Adolescent; Amines; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Cyclohexanecarbox

2014
Can gabapentin help reduce postoperative pain in arthroscopic rotator cuff repair? A prospective, randomized, double-blind study.
    Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, 2010, Volume: 26, Issue:9 Suppl

    Topics: Aged; Amines; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Arthrosc

2010
Effect of a single dose of pregabalin on post-operative pain and pre-operative anxiety in patients undergoing discectomy.
    Acta anaesthesiologica Scandinavica, 2011, Volume: 55, Issue:5

    Topics: Adult; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Anesthesia, Intravenous; Anxie

2011
Pregabalin has an opioid-sparing effect in elderly patients after cardiac surgery: a randomized placebo-controlled trial.
    British journal of anaesthesia, 2011, Volume: 106, Issue:6

    Topics: Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Cardiac Surgical Procedures;

2011
Pregabalin has an opioid-sparing effect in elderly patients after cardiac surgery: a randomized placebo-controlled trial.
    British journal of anaesthesia, 2011, Volume: 106, Issue:6

    Topics: Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Cardiac Surgical Procedures;

2011
Pregabalin has an opioid-sparing effect in elderly patients after cardiac surgery: a randomized placebo-controlled trial.
    British journal of anaesthesia, 2011, Volume: 106, Issue:6

    Topics: Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Cardiac Surgical Procedures;

2011
Pregabalin has an opioid-sparing effect in elderly patients after cardiac surgery: a randomized placebo-controlled trial.
    British journal of anaesthesia, 2011, Volume: 106, Issue:6

    Topics: Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Cardiac Surgical Procedures;

2011
Pregabalin has an opioid-sparing effect in elderly patients after cardiac surgery: a randomized placebo-controlled trial.
    British journal of anaesthesia, 2011, Volume: 106, Issue:6

    Topics: Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Cardiac Surgical Procedures;

2011
Pregabalin has an opioid-sparing effect in elderly patients after cardiac surgery: a randomized placebo-controlled trial.
    British journal of anaesthesia, 2011, Volume: 106, Issue:6

    Topics: Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Cardiac Surgical Procedures;

2011
Pregabalin has an opioid-sparing effect in elderly patients after cardiac surgery: a randomized placebo-controlled trial.
    British journal of anaesthesia, 2011, Volume: 106, Issue:6

    Topics: Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Cardiac Surgical Procedures;

2011
Pregabalin has an opioid-sparing effect in elderly patients after cardiac surgery: a randomized placebo-controlled trial.
    British journal of anaesthesia, 2011, Volume: 106, Issue:6

    Topics: Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Cardiac Surgical Procedures;

2011
Pregabalin has an opioid-sparing effect in elderly patients after cardiac surgery: a randomized placebo-controlled trial.
    British journal of anaesthesia, 2011, Volume: 106, Issue:6

    Topics: Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analgesics, Opioid; Cardiac Surgical Procedures;

2011
Pregabalin for the treatment of abdominal adhesion pain: a randomized, double-blind, placebo-controlled trial.
    American journal of therapeutics, 2012, Volume: 19, Issue:6

    Topics: Abdomen; Abdominal Pain; Adult; Analgesics; Chronic Pain; Double-Blind Method; Female; gamma-Aminobu

2012
Effects of a single 1200-mg preoperative dose of gabapentin on anxiety and memory.
    Annales francaises d'anesthesie et de reanimation, 2012, Volume: 31, Issue:10

    Topics: Adult; Aged; Amines; Analgesics; Anesthesia, General; Anti-Anxiety Agents; Anxiety; Cyclohexanecarbo

2012
Effect of gabapentin on postoperative pain and operation complications: a randomized placebo controlled trial.
    The West Indian medical journal, 2012, Volume: 61, Issue:2

    Topics: Amines; Analgesics; Cyclohexanecarboxylic Acids; Double-Blind Method; Female; Gabapentin; gamma-Amin

2012

Other Studies

25 other studies available for gamma-aminobutyric acid and Complication, Postoperative

ArticleYear
    JTCVS open, 2021, Volume: 8

    Topics: Acetic Acid; Albumins; Alkaline Phosphatase; Alkaloids; Amyloid beta-Peptides; Analgesics, Opioid; A

2021
Bilateral Breast Reduction Without Opioid Analgesics: A Comparative Study.
    Aesthetic surgery journal, 2017, Sep-01, Volume: 37, Issue:8

    Topics: Adult; Amines; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia, General; Anesthesia, Local;

2017
Opioid free general anesthesia: A paradigm shift?
    Revista espanola de anestesiologia y reanimacion, 2017, Volume: 64, Issue:8

    Topics: Adrenergic alpha-2 Receptor Agonists; Amines; Analgesics, Opioid; Anesthesia, General; Anesthetics,

2017
Opioid free general anesthesia: A paradigm shift?
    Revista espanola de anestesiologia y reanimacion, 2017, Volume: 64, Issue:8

    Topics: Adrenergic alpha-2 Receptor Agonists; Amines; Analgesics, Opioid; Anesthesia, General; Anesthetics,

2017
Opioid free general anesthesia: A paradigm shift?
    Revista espanola de anestesiologia y reanimacion, 2017, Volume: 64, Issue:8

    Topics: Adrenergic alpha-2 Receptor Agonists; Amines; Analgesics, Opioid; Anesthesia, General; Anesthetics,

2017
Opioid free general anesthesia: A paradigm shift?
    Revista espanola de anestesiologia y reanimacion, 2017, Volume: 64, Issue:8

    Topics: Adrenergic alpha-2 Receptor Agonists; Amines; Analgesics, Opioid; Anesthesia, General; Anesthetics,

2017
Opioid free general anesthesia: A paradigm shift?
    Revista espanola de anestesiologia y reanimacion, 2017, Volume: 64, Issue:8

    Topics: Adrenergic alpha-2 Receptor Agonists; Amines; Analgesics, Opioid; Anesthesia, General; Anesthetics,

2017
Opioid free general anesthesia: A paradigm shift?
    Revista espanola de anestesiologia y reanimacion, 2017, Volume: 64, Issue:8

    Topics: Adrenergic alpha-2 Receptor Agonists; Amines; Analgesics, Opioid; Anesthesia, General; Anesthetics,

2017
Opioid free general anesthesia: A paradigm shift?
    Revista espanola de anestesiologia y reanimacion, 2017, Volume: 64, Issue:8

    Topics: Adrenergic alpha-2 Receptor Agonists; Amines; Analgesics, Opioid; Anesthesia, General; Anesthetics,

2017
Opioid free general anesthesia: A paradigm shift?
    Revista espanola de anestesiologia y reanimacion, 2017, Volume: 64, Issue:8

    Topics: Adrenergic alpha-2 Receptor Agonists; Amines; Analgesics, Opioid; Anesthesia, General; Anesthetics,

2017
Opioid free general anesthesia: A paradigm shift?
    Revista espanola de anestesiologia y reanimacion, 2017, Volume: 64, Issue:8

    Topics: Adrenergic alpha-2 Receptor Agonists; Amines; Analgesics, Opioid; Anesthesia, General; Anesthetics,

2017
Opioid free general anesthesia: A paradigm shift?
    Revista espanola de anestesiologia y reanimacion, 2017, Volume: 64, Issue:8

    Topics: Adrenergic alpha-2 Receptor Agonists; Amines; Analgesics, Opioid; Anesthesia, General; Anesthetics,

2017
Opioid free general anesthesia: A paradigm shift?
    Revista espanola de anestesiologia y reanimacion, 2017, Volume: 64, Issue:8

    Topics: Adrenergic alpha-2 Receptor Agonists; Amines; Analgesics, Opioid; Anesthesia, General; Anesthetics,

2017
Opioid free general anesthesia: A paradigm shift?
    Revista espanola de anestesiologia y reanimacion, 2017, Volume: 64, Issue:8

    Topics: Adrenergic alpha-2 Receptor Agonists; Amines; Analgesics, Opioid; Anesthesia, General; Anesthetics,

2017
Opioid free general anesthesia: A paradigm shift?
    Revista espanola de anestesiologia y reanimacion, 2017, Volume: 64, Issue:8

    Topics: Adrenergic alpha-2 Receptor Agonists; Amines; Analgesics, Opioid; Anesthesia, General; Anesthetics,

2017
Opioid free general anesthesia: A paradigm shift?
    Revista espanola de anestesiologia y reanimacion, 2017, Volume: 64, Issue:8

    Topics: Adrenergic alpha-2 Receptor Agonists; Amines; Analgesics, Opioid; Anesthesia, General; Anesthetics,

2017
Opioid free general anesthesia: A paradigm shift?
    Revista espanola de anestesiologia y reanimacion, 2017, Volume: 64, Issue:8

    Topics: Adrenergic alpha-2 Receptor Agonists; Amines; Analgesics, Opioid; Anesthesia, General; Anesthetics,

2017
Opioid free general anesthesia: A paradigm shift?
    Revista espanola de anestesiologia y reanimacion, 2017, Volume: 64, Issue:8

    Topics: Adrenergic alpha-2 Receptor Agonists; Amines; Analgesics, Opioid; Anesthesia, General; Anesthetics,

2017
Opioid free general anesthesia: A paradigm shift?
    Revista espanola de anestesiologia y reanimacion, 2017, Volume: 64, Issue:8

    Topics: Adrenergic alpha-2 Receptor Agonists; Amines; Analgesics, Opioid; Anesthesia, General; Anesthetics,

2017
Opioid free general anesthesia: A paradigm shift?
    Revista espanola de anestesiologia y reanimacion, 2017, Volume: 64, Issue:8

    Topics: Adrenergic alpha-2 Receptor Agonists; Amines; Analgesics, Opioid; Anesthesia, General; Anesthetics,

2017
Opioid free general anesthesia: A paradigm shift?
    Revista espanola de anestesiologia y reanimacion, 2017, Volume: 64, Issue:8

    Topics: Adrenergic alpha-2 Receptor Agonists; Amines; Analgesics, Opioid; Anesthesia, General; Anesthetics,

2017
Opioid free general anesthesia: A paradigm shift?
    Revista espanola de anestesiologia y reanimacion, 2017, Volume: 64, Issue:8

    Topics: Adrenergic alpha-2 Receptor Agonists; Amines; Analgesics, Opioid; Anesthesia, General; Anesthetics,

2017
Opioid free general anesthesia: A paradigm shift?
    Revista espanola de anestesiologia y reanimacion, 2017, Volume: 64, Issue:8

    Topics: Adrenergic alpha-2 Receptor Agonists; Amines; Analgesics, Opioid; Anesthesia, General; Anesthetics,

2017
Opioid free general anesthesia: A paradigm shift?
    Revista espanola de anestesiologia y reanimacion, 2017, Volume: 64, Issue:8

    Topics: Adrenergic alpha-2 Receptor Agonists; Amines; Analgesics, Opioid; Anesthesia, General; Anesthetics,

2017
Opioid free general anesthesia: A paradigm shift?
    Revista espanola de anestesiologia y reanimacion, 2017, Volume: 64, Issue:8

    Topics: Adrenergic alpha-2 Receptor Agonists; Amines; Analgesics, Opioid; Anesthesia, General; Anesthetics,

2017
Opioid free general anesthesia: A paradigm shift?
    Revista espanola de anestesiologia y reanimacion, 2017, Volume: 64, Issue:8

    Topics: Adrenergic alpha-2 Receptor Agonists; Amines; Analgesics, Opioid; Anesthesia, General; Anesthetics,

2017
Opioid free general anesthesia: A paradigm shift?
    Revista espanola de anestesiologia y reanimacion, 2017, Volume: 64, Issue:8

    Topics: Adrenergic alpha-2 Receptor Agonists; Amines; Analgesics, Opioid; Anesthesia, General; Anesthetics,

2017
Medical treatment of post-dental extraction peripheral painful traumatic trigeminal neuropathy.
    Quintessence international (Berlin, Germany : 1985), 2013, Volume: 44, Issue:9

    Topics: Adrenal Cortex Hormones; Anticonvulsants; Diagnosis, Differential; Drug Therapy, Combination; Female

2013
Evaluation of postoperative pregabalin for attenuation of postoperative shoulder pain after thoracotomy in patients with lung cancer, a preliminary result.
    General thoracic and cardiovascular surgery, 2015, Volume: 63, Issue:2

    Topics: Adult; Aged; Analgesics; Female; gamma-Aminobutyric Acid; Humans; Lung Neoplasms; Male; Middle Aged;

2015
The association of plasma gamma-aminobutyric acid concentration with postoperative delirium in critically ill patients.
    Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine, 2014, Volume: 16, Issue:4

    Topics: Critical Illness; Delirium; gamma-Aminobutyric Acid; Humans; Multivariate Analysis; Postoperative Co

2014
Methylprednisolone reduces pain and decreases knee swelling in the first 24 h after fast-track unicompartmental knee arthroplasty.
    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2017, Volume: 25, Issue:1

    Topics: Acetaminophen; Aged; Aged, 80 and over; Amines; Analgesics; Anti-Inflammatory Agents; Arthroplasty,

2017
Methylprednisolone reduces pain and decreases knee swelling in the first 24 h after fast-track unicompartmental knee arthroplasty.
    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2017, Volume: 25, Issue:1

    Topics: Acetaminophen; Aged; Aged, 80 and over; Amines; Analgesics; Anti-Inflammatory Agents; Arthroplasty,

2017
Methylprednisolone reduces pain and decreases knee swelling in the first 24 h after fast-track unicompartmental knee arthroplasty.
    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2017, Volume: 25, Issue:1

    Topics: Acetaminophen; Aged; Aged, 80 and over; Amines; Analgesics; Anti-Inflammatory Agents; Arthroplasty,

2017
Methylprednisolone reduces pain and decreases knee swelling in the first 24 h after fast-track unicompartmental knee arthroplasty.
    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2017, Volume: 25, Issue:1

    Topics: Acetaminophen; Aged; Aged, 80 and over; Amines; Analgesics; Anti-Inflammatory Agents; Arthroplasty,

2017
Management of Peripheral Entrapment Neuropathy Following Abdominoplasty: A Case Report.
    Aesthetic surgery journal, 2016, Volume: 36, Issue:6

    Topics: Abdominal Pain; Abdominoplasty; Adult; Amines; Analgesics; Cyclohexanecarboxylic Acids; Female; Foll

2016
Multimodal Analgesic Therapy With Gabapentin and Its Association With Postoperative Respiratory Depression.
    Anesthesia and analgesia, 2017, Volume: 125, Issue:1

    Topics: Adult; Aged; Amines; Analgesia; Analgesics; Analgesics, Opioid; Combined Modality Therapy; Critical

2017
A case of infant delirium in the neonatal intensive care unit.
    Journal of neonatal-perinatal medicine, 2017, Volume: 10, Issue:1

    Topics: Amines; Analgesics, Opioid; Anti-Anxiety Agents; Cardiac Catheterization; Cyclohexanecarboxylic Acid

2017
Post-traumatic short-lasting unilateral headache with cranial autonomic symptoms (SUNA).
    Cephalalgia : an international journal of headache, 2008, Volume: 28, Issue:9

    Topics: Accidents, Traffic; Adult; Amines; Carbamazepine; Conjunctiva; Cyclohexanecarboxylic Acids; Facial P

2008
The trigeminal trophic syndrome: an unusual cause of face pain, dysaesthesias, anaesthesia and skin/soft tissue lesions.
    Cephalalgia : an international journal of headache, 2008, Volume: 28, Issue:9

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amines; Child; Cyclohexanecarboxylic Acids; Erythema; Fa

2008
Gabapentin-induced hypoglycemia in a long-term peritoneal dialysis patient.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2003, Volume: 42, Issue:6

    Topics: Acetates; Amines; C-Peptide; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyric Aci

2003
Responsiveness of life-threatening refractory emesis to gabapentin-scopolamine therapy following posterior fossa surgery. Case report.
    Journal of neurosurgery, 2005, Volume: 102, Issue:3

    Topics: Amines; Antiemetics; Cholesteatoma; Cranial Fossa, Posterior; Cyclohexanecarboxylic Acids; Drug Ther

2005
Gabapentin-induced myopathy in 2 patients on short daily hemodialysis.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2005, Volume: 45, Issue:6

    Topics: Adult; Amines; Anticonvulsants; Atorvastatin; Calcium Channels; Comorbidity; Cyclohexanecarboxylic A

2005
Motor cortex stimulation for central pain following a traumatic brain injury.
    Pain, 2006, Volume: 123, Issue:1-2

    Topics: Accidental Falls; Adult; Amines; Amitriptyline; Analgesics, Non-Narcotic; Aphasia, Broca; Brain Inju

2006
[This is the anaesthetist's fault! (About the post-anaesthetic consultation)].
    Annales francaises d'anesthesie et de reanimation, 2007, Volume: 26, Issue:2

    Topics: Accidental Falls; Acromioclavicular Joint; Adult; Amines; Analgesia; Anesthesia, Local; Anesthesiolo

2007
Prolonged myotonia and dystonia after general anaesthesia in a patient taking gabapentin.
    British journal of anaesthesia, 2007, Volume: 99, Issue:2

    Topics: Amines; Analgesics; Anesthetics, General; Cyclohexanecarboxylic Acids; Drug Interactions; Dystonia;

2007
Gabapentin for the treatment of neuropathic pain in a pregnant horse.
    Journal of the American Veterinary Medical Association, 2007, Sep-01, Volume: 231, Issue:5

    Topics: Amines; Analgesics; Animals; Colic; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobuty

2007
Recurrent postoperative CRPS I in patients with abnormal preoperative sympathetic function.
    The Journal of hand surgery, 2008, Volume: 33, Issue:2

    Topics: Adult; Amines; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Autonomic Nerve Block; Carpal Tu

2008
Gabapentin for treatment of neuropathic pain in a 12-year-old girl.
    The Clinical journal of pain, 1998, Volume: 14, Issue:4

    Topics: Acetates; Amines; Child; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyric Acid; H

1998
Square-wave jerks induced by pallidotomy in parkinsonian patients.
    Neurology, 1999, Jan-01, Volume: 52, Issue:1

    Topics: Adult; Aged; Female; Fixation, Ocular; gamma-Aminobutyric Acid; Globus Pallidus; Humans; Male; Neura

1999
Using gabapentin to treat failed back surgery syndrome caused by epidural fibrosis: A report of 2 cases.
    Archives of physical medicine and rehabilitation, 2001, Volume: 82, Issue:5

    Topics: Acetates; Adult; Aged; Aged, 80 and over; Amines; Analgesics; Cyclohexanecarboxylic Acids; Diagnosis

2001
[Current aspects of the surgery of portal hypertension (PH)].
    Minerva chirurgica, 1975, Apr-15, Volume: 30, Issue:7

    Topics: Animals; Brain; Brain Diseases; Catecholamines; Enzymes; Esophageal and Gastric Varices; gamma-Amino

1975
Plasma and cerebrospinal fluid levels of baclofen (Lioresal) at optimal therapeutic responses in spastic paresis.
    Journal of the neurological sciences, 1974, Volume: 23, Issue:3

    Topics: Adolescent; Adult; Aged; Aminobutyrates; Cold Temperature; Female; gamma-Aminobutyric Acid; Humans;

1974