gamma-aminobutyric acid has been researched along with Cognitive Decline in 52 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Aging is known to affect adversely the corticosterone status and the brain function including cognition." | 7.96 | Calorie restriction improves aging-induced impairment of cognitive function in relation to deregulation of corticosterone status and brain regional GABA system. ( Banerjee, S; Chakraborty, A; Mukherjee, B; Poddar, MK, 2020) |
| "Carvacrol, a naturally occurring inhibitor of TRPM7 channels, is a novel, promising treatment to prevent early recurrence of SE, SE-related neuronal damage, and cognitive decline." | 7.85 | Carvacrol after status epilepticus (SE) prevents recurrent SE, early seizures, cell death, and cognitive decline. ( Khalil, A; Kovac, S; Morris, G; Walker, MC, 2017) |
| "Compared with HC, schizophrenia patients had lower cognitive performance, higher methionine concentrations, decreased concentrations of glutamic acid, cysteine, aspartic acid, arginine, the ratio of glutamic acid to gamma-aminobutyric acid (Glu/GABA), and DAT availability in the left caudate nucleus (CN) and putamen." | 4.12 | Interactions between dopamine transporter and N-methyl-d-aspartate receptor-related amino acids on cognitive impairments in schizophrenia. ( Chen, YY; Chou, YH; Liu, MN; Yang, BH; Yang, KC, 2022) |
| "Aging is known to affect adversely the corticosterone status and the brain function including cognition." | 3.96 | Calorie restriction improves aging-induced impairment of cognitive function in relation to deregulation of corticosterone status and brain regional GABA system. ( Banerjee, S; Chakraborty, A; Mukherjee, B; Poddar, MK, 2020) |
| "Carvacrol, a naturally occurring inhibitor of TRPM7 channels, is a novel, promising treatment to prevent early recurrence of SE, SE-related neuronal damage, and cognitive decline." | 3.85 | Carvacrol after status epilepticus (SE) prevents recurrent SE, early seizures, cell death, and cognitive decline. ( Khalil, A; Kovac, S; Morris, G; Walker, MC, 2017) |
| "Thirty adults (17 with mild cognitive impairment [MCI]), ranging in age from 55 to 87 years, were enrolled and successfully completed the study." | 2.78 | Growth hormone-releasing hormone effects on brain γ-aminobutyric acid levels in mild cognitive impairment and healthy aging. ( Baker, LD; Barsness, SM; Borson, S; Craft, S; Friedman, SD; Jensen, JE; Merriam, GR; Novotny, EJ; Otto, RK; Vitiello, MV, 2013) |
| "Chronic neuropathic pain often leads to cognitive impairment, but the exact mechanism remains unclear." | 1.72 | Hippocampal Inhibitory Synapsis Deficits Induced by α5-Containing GABA ( Cai, W; Cai, X; Mao, M; Qiu, L; Sun, J; Wang, C; Wen, Y; Yang, H; Zhou, Z; Zhu, W; Zhu, Y, 2022) |
| "Bisphenol A (BPA) is a well-recognized endocrine disruptor and is globally used in the manufacture of many plastic items." | 1.62 | Gamma aminobutyric acid signaling disturbances and altered astrocytic morphology associated with Bisphenol A induced cognitive impairments in rat offspring. ( Kazi, SAF; Memon, S; Nizamani, GS; Singha, SP, 2021) |
| "Acute seizures were induced in zebrafish using pentylenetetrazol (PTZ) and cognitive function was assessed using the T-maze test of learning and memory." | 1.51 | Effect of newer anti-epileptic drugs (AEDs) on the cognitive status in pentylenetetrazol induced seizures in a zebrafish model. ( Choo, BKM; Johan Arief, MFB; Kumari, Y; Kundap, UP; Othman, I; Shaikh, MF; Wong, CP; Yap, JL, 2019) |
| "Epilepsy is marked by seizures that are a manifestation of excessive brain activity and is symptomatically treatable by anti-epileptic drugs (AEDs)." | 1.51 | Effect of newer anti-epileptic drugs (AEDs) on the cognitive status in pentylenetetrazol induced seizures in a zebrafish model. ( Choo, BKM; Johan Arief, MFB; Kumari, Y; Kundap, UP; Othman, I; Shaikh, MF; Wong, CP; Yap, JL, 2019) |
| "Type 2 diabetes mellitus is associated with accelerated cognitive decline." | 1.43 | Increased GABA concentrations in type 2 diabetes mellitus are related to lower cognitive functioning. ( Backes, WH; Edden, RAE; Hofman, PAM; Jansen, JFA; Puts, NAJ; Schram, MT; Stehouwer, CDA; van Boxtel, MPJ; van Bussel, FCG; Wildberger, JE, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 21 (40.38) | 24.3611 |
| 2020's | 31 (59.62) | 2.80 |
| Authors | Studies |
|---|---|
| Lengu, K | 1 |
| Ryan, S | 1 |
| Peltier, SJ | 1 |
| Tyszkowski, T | 1 |
| Kairys, A | 1 |
| Giordani, B | 1 |
| Hampstead, BM | 1 |
| Cho, SY | 1 |
| Kwon, S | 1 |
| Shin, HY | 1 |
| Kim, HR | 2 |
| Kim, JH | 1 |
| Park, S | 1 |
| Ryu, CW | 1 |
| Park, JM | 1 |
| Edden, RAE | 6 |
| Jahng, GH | 1 |
| Bruzelius, A | 1 |
| Kidnapillai, S | 1 |
| Drouin-Ouellet, J | 1 |
| Stoker, T | 1 |
| Barker, RA | 1 |
| Rylander Ottosson, D | 1 |
| Yang, Y | 3 |
| Rui, Q | 1 |
| Han, S | 1 |
| Wu, X | 1 |
| Wang, X | 1 |
| Wu, P | 1 |
| Shen, Y | 1 |
| Dai, H | 1 |
| Xue, Q | 1 |
| Li, Y | 2 |
| Xu, P | 1 |
| Huang, X | 1 |
| Niu, W | 1 |
| Yu, D | 1 |
| Zhou, M | 1 |
| Wang, H | 1 |
| Hone-Blanchet, A | 1 |
| Bohsali, A | 1 |
| Krishnamurthy, LC | 1 |
| Shahid, SS | 1 |
| Lin, Q | 1 |
| Zhao, L | 1 |
| Bisht, AS | 1 |
| John, SE | 1 |
| Loring, D | 1 |
| Goldstein, F | 1 |
| Levey, A | 1 |
| Lah, J | 1 |
| Qiu, D | 1 |
| Crosson, B | 1 |
| Zhu, N | 1 |
| Wei, M | 1 |
| Yuan, L | 1 |
| He, X | 1 |
| Chen, C | 1 |
| Ji, A | 1 |
| Zhang, G | 1 |
| Li, J | 2 |
| Pu, F | 1 |
| Peng, C | 1 |
| Wang, Y | 1 |
| Zhang, Y | 3 |
| Wu, S | 1 |
| Wang, S | 1 |
| Shen, X | 1 |
| Cheng, R | 1 |
| He, F | 1 |
| Cai, X | 1 |
| Qiu, L | 1 |
| Wang, C | 2 |
| Yang, H | 1 |
| Zhou, Z | 1 |
| Mao, M | 1 |
| Zhu, Y | 1 |
| Wen, Y | 1 |
| Cai, W | 1 |
| Zhu, W | 1 |
| Sun, J | 1 |
| Zhang, D | 1 |
| Liu, J | 1 |
| Zhu, T | 1 |
| Huang, H | 1 |
| Zhou, C | 1 |
| Won, W | 1 |
| Choi, HJ | 1 |
| Yoo, JY | 1 |
| Kim, D | 1 |
| Kim, TY | 1 |
| Ju, Y | 1 |
| Park, KD | 2 |
| Lee, H | 1 |
| Jung, SY | 1 |
| Lee, CJ | 2 |
| Yang, KC | 1 |
| Chen, YY | 1 |
| Liu, MN | 1 |
| Yang, BH | 1 |
| Chou, YH | 1 |
| Xu, D | 1 |
| Zhao, M | 1 |
| Li, N | 1 |
| Ma, W | 1 |
| Ren, F | 1 |
| Li, X | 1 |
| Li, F | 1 |
| Zong, W | 1 |
| Wu, L | 1 |
| Dai, Z | 1 |
| Hui, SCN | 1 |
| Li, M | 1 |
| Gao, F | 2 |
| Zohny, SM | 1 |
| Habib, MZ | 1 |
| Mohamad, MI | 1 |
| Elayat, WM | 1 |
| Elhossiny, RM | 1 |
| El-Salam, MFA | 1 |
| Hassan, GAM | 1 |
| Aboul-Fotouh, S | 1 |
| Tınok, AA | 1 |
| Karabay, A | 1 |
| Jong, J | 1 |
| Balta, G | 1 |
| Akyürek, EG | 1 |
| Bäckström, T | 1 |
| Turkmen, S | 1 |
| Das, R | 1 |
| Doverskog, M | 1 |
| Blackburn, TP | 1 |
| Kotlinska, JH | 1 |
| Grochecki, P | 1 |
| Michalak, A | 1 |
| Pankowska, A | 1 |
| Kochalska, K | 1 |
| Suder, P | 1 |
| Ner-Kluza, J | 1 |
| Matosiuk, D | 1 |
| Marszalek-Grabska, M | 1 |
| Li, JN | 1 |
| Liu, XL | 1 |
| Li, L | 1 |
| Duchon, A | 1 |
| Gruart, A | 1 |
| Albac, C | 1 |
| Delatour, B | 1 |
| Zorrilla de San Martin, J | 1 |
| Delgado-García, JM | 1 |
| Hérault, Y | 1 |
| Potier, MC | 1 |
| Reddy-Thootkur, M | 1 |
| Kraguljac, NV | 1 |
| Lahti, AC | 2 |
| Chakraborty, A | 1 |
| Banerjee, S | 1 |
| Mukherjee, B | 1 |
| Poddar, MK | 1 |
| Prévot, T | 1 |
| Sibille, E | 1 |
| Xiang, S | 1 |
| Jiang, T | 1 |
| Ke, Z | 1 |
| Shang, Y | 1 |
| Ning, W | 1 |
| Yang, Z | 1 |
| Zhang, T | 1 |
| Wenneberg, C | 1 |
| Glenthøj, BY | 1 |
| Glenthøj, LB | 1 |
| Fagerlund, B | 1 |
| Krakauer, K | 1 |
| Kristensen, TD | 1 |
| Hjorthøj, C | 1 |
| Broberg, BV | 1 |
| Bojesen, KB | 1 |
| Rostrup, E | 1 |
| Nordentoft, M | 1 |
| Tai, F | 1 |
| Deng, X | 1 |
| Li, R | 1 |
| Guo, Z | 1 |
| Quan, H | 1 |
| Li, S | 1 |
| Marchese, E | 1 |
| Valentini, M | 1 |
| Di Sante, G | 1 |
| Cesari, E | 1 |
| Adinolfi, A | 1 |
| Corvino, V | 1 |
| Ria, F | 1 |
| Sette, C | 1 |
| Geloso, MC | 1 |
| Chen, L | 1 |
| Guo, F | 1 |
| Han, X | 1 |
| Arsenijevic, N | 1 |
| Selakovic, D | 1 |
| Katanic Stankovic, JS | 1 |
| Mihailovic, V | 1 |
| Mitrovic, S | 1 |
| Milenkovic, J | 1 |
| Milanovic, P | 1 |
| Vasovic, M | 1 |
| Markovic, SD | 1 |
| Zivanovic, M | 1 |
| Grujic, J | 1 |
| Jovicic, N | 1 |
| Rosic, G | 1 |
| Singha, SP | 1 |
| Memon, S | 1 |
| Kazi, SAF | 1 |
| Nizamani, GS | 1 |
| Rajagopal, L | 1 |
| Meltzer, HY | 1 |
| Martina, M | 1 |
| Rozycka, A | 1 |
| Liguz-Lecznar, M | 1 |
| Lietzau, G | 1 |
| Darsalia, V | 1 |
| Pintana, H | 1 |
| Östenson, CG | 1 |
| Nyström, T | 1 |
| Fisahn, A | 1 |
| Patrone, C | 1 |
| Thorajak, P | 1 |
| Pannangrong, W | 1 |
| Welbat, JU | 1 |
| Chaijaroonkhanarak, W | 1 |
| Sripanidkulchai, K | 1 |
| Sripanidkulchai, B | 1 |
| Coimbra, B | 1 |
| Soares-Cunha, C | 1 |
| Borges, S | 1 |
| Vasconcelos, NA | 1 |
| Sousa, N | 1 |
| Rodrigues, AJ | 1 |
| Heckova, E | 1 |
| Považan, M | 1 |
| Strasser, B | 1 |
| Krumpolec, P | 1 |
| Hnilicová, P | 1 |
| Hangel, GJ | 1 |
| Moser, PA | 1 |
| Andronesi, OC | 1 |
| van der Kouwe, AJ | 1 |
| Valkovic, P | 1 |
| Ukropcova, B | 1 |
| Trattnig, S | 1 |
| Bogner, W | 1 |
| Cao, G | 1 |
| Li, H | 1 |
| Gong, T | 1 |
| Chen, W | 1 |
| Liu, X | 1 |
| Wang, G | 1 |
| Zhao, B | 1 |
| Reid, MA | 1 |
| Salibi, N | 1 |
| White, DM | 1 |
| Gawne, TJ | 1 |
| Denney, TS | 1 |
| Wolfrum, C | 1 |
| Peleg-Raibstein, D | 1 |
| Yamazaki, M | 1 |
| Yamamoto, N | 1 |
| Yarimizu, J | 1 |
| Okabe, M | 1 |
| Moriyama, A | 1 |
| Furutani, M | 1 |
| Marcus, MM | 1 |
| Svensson, TH | 1 |
| Harada, K | 1 |
| Marenco, S | 1 |
| Meyer, C | 1 |
| van der Veen, JW | 1 |
| Kelly, R | 1 |
| Shen, J | 1 |
| Weinberger, DR | 1 |
| Dickinson, D | 1 |
| Berman, KF | 1 |
| Oeltzschner, G | 1 |
| Wijtenburg, SA | 1 |
| Mikkelsen, M | 1 |
| Barker, PB | 1 |
| Joo, JH | 1 |
| Leoutsakos, JS | 1 |
| Rowland, LM | 1 |
| Workman, CI | 1 |
| Smith, GS | 1 |
| Tan, T | 1 |
| Wang, W | 1 |
| Williams, J | 1 |
| Ma, K | 1 |
| Cao, Q | 1 |
| Yan, Z | 1 |
| Venkatesh, G | 1 |
| Sankar, V | 1 |
| Ramanathan, M | 1 |
| Choo, BKM | 1 |
| Kundap, UP | 1 |
| Johan Arief, MFB | 1 |
| Kumari, Y | 1 |
| Yap, JL | 1 |
| Wong, CP | 1 |
| Othman, I | 1 |
| Shaikh, MF | 1 |
| Park, JH | 1 |
| Ju, YH | 1 |
| Choi, JW | 1 |
| Song, HJ | 1 |
| Jang, BK | 1 |
| Woo, J | 1 |
| Chun, H | 1 |
| Kim, HJ | 1 |
| Shin, SJ | 1 |
| Yarishkin, O | 1 |
| Jo, S | 1 |
| Park, M | 1 |
| Yeon, SK | 1 |
| Kim, S | 1 |
| Kim, J | 2 |
| Nam, MH | 1 |
| Londhe, AM | 1 |
| Cho, SJ | 1 |
| Cho, S | 1 |
| Lee, C | 1 |
| Hwang, SY | 1 |
| Kim, SW | 1 |
| Oh, SJ | 1 |
| Cho, J | 1 |
| Pae, AN | 1 |
| Friedman, SD | 1 |
| Baker, LD | 1 |
| Borson, S | 1 |
| Jensen, JE | 1 |
| Barsness, SM | 1 |
| Craft, S | 1 |
| Merriam, GR | 1 |
| Otto, RK | 1 |
| Novotny, EJ | 1 |
| Vitiello, MV | 1 |
| Riese, F | 1 |
| Gietl, A | 1 |
| Zölch, N | 1 |
| Henning, A | 1 |
| O'Gorman, R | 1 |
| Kälin, AM | 1 |
| Leh, SE | 1 |
| Buck, A | 1 |
| Warnock, G | 1 |
| Edden, RA | 1 |
| Luechinger, R | 1 |
| Hock, C | 1 |
| Kollias, S | 1 |
| Michels, L | 1 |
| van Bussel, FCG | 1 |
| Backes, WH | 1 |
| Hofman, PAM | 1 |
| Puts, NAJ | 1 |
| van Boxtel, MPJ | 1 |
| Schram, MT | 1 |
| Stehouwer, CDA | 1 |
| Wildberger, JE | 1 |
| Jansen, JFA | 1 |
| Hui, AT | 1 |
| Lam, YO | 1 |
| Chan, CK | 1 |
| Cheung, KY | 1 |
| Fung, BH | 1 |
| Ng, PW | 1 |
| Huang, D | 1 |
| Liu, D | 1 |
| Yin, J | 1 |
| Qian, T | 1 |
| Shrestha, S | 1 |
| Ni, H | 1 |
| Khalil, A | 1 |
| Kovac, S | 1 |
| Morris, G | 1 |
| Walker, MC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Enhancing Spatial Navigation Using Non-Invasive Brain Stimulation[NCT01958437] | 44 participants (Actual) | Interventional | 2013-10-01 | Completed | |||
| Structural and Functional Imaging of Neuropsychiatric Patients and Normal Volunteers With 3.0 Tesla MRI and Magnetoencephalography (MEG)[NCT00004571] | 3,420 participants (Anticipated) | Observational | 2000-02-17 | Recruiting | |||
| A Neurobiological Investigation of Patients With Schizophrenia Spectrum Disorders and Their Siblings[NCT00001486] | 6,150 participants (Anticipated) | Observational | 1995-07-15 | Recruiting | |||
| GHRH: Cognition in Aging and MCI[NCT00257712] | Phase 2 | 151 participants (Actual) | Interventional | 2006-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"1 active tDCS; 1 sham tDCS for each measure. Participants touched a screen (using a ELO 19 touchscreen monitor) to document the location of the landmark. The distance between the actual vs. selected location served as the dependent measure." (NCT01958437)
Timeframe: Outcome assessed after each of 2 sessions (estimated within 1 week of each other)
| Intervention | Centimeters (cm) (Mean) |
|---|---|
| Cognitively Intact ACTIVE tDCS | 13.24 |
| MCI ACTIVE tDCS | 15.38 |
| Cognitively Intact SHAM tDCS | 14.22 |
| MCI SHAM tDCS | 15.03 |
Change in resting state functional connectivity strength between active and sham tDCS sessions. Strength is measured by Pearson r correlations between nodes, which are z-transformed, and summated. (NCT01958437)
Timeframe: change between active and sham tDCS sessions (<1month)
| Intervention | arbitrary units (Mean) |
|---|---|
| Cognitively Intact ACTIVE tDCS | 29.41 |
| MCI ACTIVE HD-tDCS | 30.93 |
| Cognitively Intact SHAM HD-tDCS | 30.39 |
| MCI SHAM HD-tDCS | 31.47 |
Number of turns correctly recalled for each egocentric environment (NCT01958437)
Timeframe: Outcome assessed after each of the 2 sessions
| Intervention | Correct turns (Mean) |
|---|---|
| Cognitively Intact ACTIVE tDCS | 9.05 |
| MCI ACTIVE tDCS | 8.21 |
| Cognitively Intact SHAM tDCS | 9.85 |
| MCI SHAM tDCS | 7.47 |
BOLD signal change comparing active to sham tDCS during Allocentric navigation (i.e., active HD-tDCS > sham HD-tDCS). Activation maps thresholded at p<.01 with minimum cluster size of 5 voxels. (NCT01958437)
Timeframe: change between active and sham tDCS sessions (<1month)
| Intervention | Percent signal change (Mean) |
|---|---|
| MCI ACTIVE tDCS | .089 |
| MCI Sham HD-tDCS | .037 |
| Cognitively Intact ACTIVE HD-tDCS | .143 |
| Cognitively Intact Sham HD-tDCS | .107 |
5 reviews available for gamma-aminobutyric acid and Cognitive Decline
| Article | Year |
|---|---|
The GABA system, a new target for medications against cognitive impairment-Associated with neuroactive steroids.
Topics: Aged; Alzheimer Disease; Animals; Cognitive Dysfunction; gamma-Aminobutyric Acid; Humans; Neurostero | 2023 |
The role of glutamate and GABA in cognitive dysfunction in schizophrenia and mood disorders - A systematic review of magnetic resonance spectroscopy studies.
Topics: Brain; Cognitive Dysfunction; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Magnetic Resonance Spe | 2022 |
Altered GABA-mediated information processing and cognitive dysfunctions in depression and other brain disorders.
Topics: Brain Diseases; Cognition; Cognitive Dysfunction; Depression; gamma-Aminobutyric Acid; Humans; Inter | 2021 |
The Effects of GABAergic System under Cerebral Ischemia: Spotlight on Cognitive Function.
Topics: Animals; Brain Ischemia; Cognition; Cognitive Dysfunction; gamma-Aminobutyric Acid; Hippocampus; Hum | 2020 |
The space where aging acts: focus on the GABAergic synapse.
Topics: Aging; Animals; Calbindin 2; Calbindins; Cell Count; Cognitive Dysfunction; GABAergic Neurons; gamma | 2017 |
3 trials available for gamma-aminobutyric acid and Cognitive Decline
| Article | Year |
|---|---|
Effects of High Definition-Transcranial Direct Current Stimulation on Local GABA and Glutamate Levels Among Older Adults with and without Mild Cognitive Impairment: An Exploratory Study.
Topics: Aged; Cognitive Dysfunction; Double-Blind Method; Female; gamma-Aminobutyric Acid; Glutamic Acid; Hu | 2021 |
Effects of gamma-aminobutyric acid on working memory and attention: A randomized, double-blinded, placebo-controlled, crossover trial.
Topics: Cognition; Cognitive Dysfunction; Cross-Over Studies; Double-Blind Method; Female; gamma-Aminobutyri | 2023 |
Growth hormone-releasing hormone effects on brain γ-aminobutyric acid levels in mild cognitive impairment and healthy aging.
Topics: Aged; Aged, 80 and over; Aging; Brain Chemistry; Cognitive Dysfunction; Double-Blind Method; Female; | 2013 |
44 other studies available for gamma-aminobutyric acid and Cognitive Decline
| Article | Year |
|---|---|
Treatment evaluation of Kami Guibi-tang on participants with amnestic mild cognitive impairment using magnetic resonance imaging on brain metabolites, gamma-aminobutyric acid, and cerebral blood flow.
Topics: Brain; Cerebrovascular Circulation; Cognitive Dysfunction; Drugs, Chinese Herbal; gamma-Aminobutyric | 2021 |
Reprogramming Human Adult Fibroblasts into GABAergic Interneurons.
Topics: Adult; Brain Diseases; Cell Differentiation; Cellular Reprogramming; Cognitive Dysfunction; Fibrobla | 2021 |
Reduced GABA levels in the medial prefrontal cortex are associated with cognitive impairment in patients with NMOSD.
Topics: Cognitive Dysfunction; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Magnetic Resonance Imaging; M | 2022 |
Metabotropic glutamate receptor 5 upregulation of γ-aminobutyric acid transporter 3 expression ameliorates cognitive impairment after traumatic brain injury in mice.
Topics: Animals; Brain Injuries, Traumatic; Cognitive Dysfunction; gamma-Aminobutyric Acid; GATA3 Transcript | 2022 |
Frontal Metabolites and Alzheimer's Disease Biomarkers in Healthy Older Women and Women Diagnosed with Mild Cognitive Impairment.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Cognitive Dysfunction | 2022 |
Claudin-5 relieves cognitive decline in Alzheimer's disease mice through suppression of inhibitory GABAergic neurotransmission.
Topics: Alzheimer Disease; Animals; Claudin-5; Cognitive Dysfunction; Disease Models, Animal; gamma-Aminobut | 2022 |
Antibiotic cocktail-induced gut microbiota depletion in different stages could cause host cognitive impairment and emotional disorders in adulthood in different manners.
Topics: Animals; Anti-Bacterial Agents; Behavior, Animal; Cognitive Dysfunction; gamma-Aminobutyric Acid; Ga | 2022 |
Hippocampal Inhibitory Synapsis Deficits Induced by α5-Containing GABA
Topics: Animals; Chromosome Pairing; Cognitive Dysfunction; gamma-Aminobutyric Acid; Hippocampus; Neuralgia; | 2022 |
Severe inflammation in new-borns induces long-term cognitive impairment by activation of IL-1β/KCC2 signaling during early development.
Topics: Animals; Cognitive Dysfunction; gamma-Aminobutyric Acid; Hippocampus; Inflammation; Interleukin-1bet | 2022 |
Inhibiting peripheral and central MAO-B ameliorates joint inflammation and cognitive impairment in rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Cells, Cultured; Cognitive Dysfunction; Fibroblasts; gamma-Aminobuty | 2022 |
Interactions between dopamine transporter and N-methyl-d-aspartate receptor-related amino acids on cognitive impairments in schizophrenia.
Topics: Amino Acids; Arginine; Aspartic Acid; Cognitive Dysfunction; Corpus Striatum; Cysteine; Dopamine; Do | 2022 |
Topics: Acetylcholine; Animals; Brain-Derived Neurotrophic Factor; Caspase 3; Cognitive Dysfunction; Dipepti | 2022 |
Neurochemical and functional reorganization of the cognitive-ear link underlies cognitive impairment in presbycusis.
Topics: Cognition; Cognitive Dysfunction; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Magnetic Resonance | 2023 |
Memantine/Aripiprazole Combination Alleviates Cognitive Dysfunction in Valproic Acid Rat Model of Autism: Hippocampal CREB/BDNF Signaling and Glutamate Homeostasis.
Topics: Animals; Aripiprazole; Autism Spectrum Disorder; Autistic Disorder; Brain-Derived Neurotrophic Facto | 2023 |
Neonatal Maternal Separation Induces Sexual Dimorphism in Brain Development: The Influence on Amino Acid Levels and Cognitive Disorders.
Topics: Amino Acids; Animals; Brain; Cognitive Dysfunction; Female; gamma-Aminobutyric Acid; Glutamic Acid; | 2023 |
Prefrontal GABA and glutamate levels correlate with impulsivity and cognitive function of prescription opioid addicts: A
Topics: Adult; Antitussive Agents; Codeine; Cognitive Dysfunction; Female; gamma-Aminobutyric Acid; Glutamic | 2020 |
Long-lasting correction of in vivo LTP and cognitive deficits of mice modelling Down syndrome with an α5-selective GABA
Topics: Animals; Cognition; Cognitive Dysfunction; Disease Models, Animal; Down Syndrome; GABA-A Receptor Ag | 2020 |
Calorie restriction improves aging-induced impairment of cognitive function in relation to deregulation of corticosterone status and brain regional GABA system.
Topics: Aging; Animals; Brain; Caloric Restriction; Cognition; Cognitive Dysfunction; Corticosterone; gamma- | 2020 |
Knockdown of Follistatin-like 1 disrupts synaptic transmission in hippocampus and leads to cognitive impairments.
Topics: Animals; Cognitive Dysfunction; Follistatin-Related Proteins; gamma-Aminobutyric Acid; Gene Expressi | 2020 |
Baseline measures of cerebral glutamate and GABA levels in individuals at ultrahigh risk for psychosis: Implications for clinical outcome after 12 months.
Topics: Adolescent; Adult; Brain Chemistry; Cognition; Cognitive Dysfunction; gamma-Aminobutyric Acid; Gluta | 2020 |
Treadmill exercise ameliorates chronic REM sleep deprivation-induced anxiety-like behavior and cognitive impairment in C57BL/6J mice.
Topics: Animals; Anxiety; Behavior, Animal; Cognitive Dysfunction; Dopamine; gamma-Aminobutyric Acid; Hippoc | 2020 |
Alternative splicing of neurexins 1-3 is modulated by neuroinflammation in the prefrontal cortex of a murine model of multiple sclerosis.
Topics: Alternative Splicing; Animals; Calcium-Binding Proteins; Cognitive Dysfunction; Encephalitis; Enceph | 2021 |
The Beneficial Role of
Topics: Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Calcium Phosphates; Cognitive Dysfunction; De | 2021 |
Gamma aminobutyric acid signaling disturbances and altered astrocytic morphology associated with Bisphenol A induced cognitive impairments in rat offspring.
Topics: Animals; Astrocytes; Benzhydryl Compounds; Cognitive Dysfunction; Female; gamma-Aminobutyric Acid; P | 2021 |
Depolarizing GABA
Topics: Animals; Bumetanide; Cognitive Dysfunction; Disease Models, Animal; gamma-Aminobutyric Acid; Mice; P | 2021 |
Type 2 diabetes alters hippocampal gamma oscillations: A potential mechanism behind impaired cognition.
Topics: Animals; Cognition; Cognitive Dysfunction; Diabetes Mellitus, Type 2; Disease Models, Animal; Gamma | 2017 |
Effects of Aged Garlic Extract on Cholinergic, Glutamatergic and GABAergic Systems with Regard to Cognitive Impairment in Aβ-Induced Rats.
Topics: Acetylcholine; Amyloid beta-Peptides; Animals; Cholinergic Neurons; Cognitive Dysfunction; gamma-Ami | 2017 |
Impairments in laterodorsal tegmentum to VTA projections underlie glucocorticoid-triggered reward deficits.
Topics: Animals; Cognitive Dysfunction; Dexamethasone; Dopamine; Female; gamma-Aminobutyric Acid; Glucocorti | 2017 |
Real-time Correction of Motion and Imager Instability Artifacts during 3D γ-Aminobutyric Acid-edited MR Spectroscopic Imaging.
Topics: Aged; Artifacts; Cognitive Dysfunction; Contrast Media; Equipment Failure; Female; gamma-Aminobutyri | 2018 |
Reduced GABA levels correlate with cognitive impairment in patients with relapsing-remitting multiple sclerosis.
Topics: Adult; Brain; Case-Control Studies; Cognitive Dysfunction; Female; gamma-Aminobutyric Acid; Gyrus Ci | 2018 |
7T Proton Magnetic Resonance Spectroscopy of the Anterior Cingulate Cortex in First-Episode Schizophrenia.
Topics: Adult; Aspartic Acid; Cognitive Dysfunction; Female; gamma-Aminobutyric Acid; Glutamic Acid; Gyrus C | 2019 |
Maternal overnutrition leads to cognitive and neurochemical abnormalities in C57BL/6 mice.
Topics: Animals; Aspartic Acid; Avoidance Learning; Brain Chemistry; Cognitive Dysfunction; Diet, High-Fat; | 2019 |
Functional mechanism of ASP5736, a selective serotonin 5-HT
Topics: Action Potentials; Animals; Cognitive Dysfunction; Discrimination, Psychological; Dopamine; Dopamine | 2018 |
Role of gamma-amino-butyric acid in the dorsal anterior cingulate in age-associated changes in cognition.
Topics: Adolescent; Adult; Aging; Cognition; Cognitive Dysfunction; Female; gamma-Aminobutyric Acid; Gyrus C | 2018 |
Role of gamma-amino-butyric acid in the dorsal anterior cingulate in age-associated changes in cognition.
Topics: Adolescent; Adult; Aging; Cognition; Cognitive Dysfunction; Female; gamma-Aminobutyric Acid; Gyrus C | 2018 |
Role of gamma-amino-butyric acid in the dorsal anterior cingulate in age-associated changes in cognition.
Topics: Adolescent; Adult; Aging; Cognition; Cognitive Dysfunction; Female; gamma-Aminobutyric Acid; Gyrus C | 2018 |
Role of gamma-amino-butyric acid in the dorsal anterior cingulate in age-associated changes in cognition.
Topics: Adolescent; Adult; Aging; Cognition; Cognitive Dysfunction; Female; gamma-Aminobutyric Acid; Gyrus C | 2018 |
Neurometabolites and associations with cognitive deficits in mild cognitive impairment: a magnetic resonance spectroscopy study at 7 Tesla.
Topics: Aged; Biomarkers; Cognition; Cognitive Dysfunction; Female; gamma-Aminobutyric Acid; Glutamates; Gyr | 2019 |
Stress Exposure in Dopamine D4 Receptor Knockout Mice Induces Schizophrenia-Like Behaviors via Disruption of GABAergic Transmission.
Topics: Animals; Behavior, Animal; Cognitive Dysfunction; Diazepam; Exploratory Behavior; Female; GABA Modul | 2019 |
Molecular mechanism of tuberoinfundibular peptide of 39 on glucocorticoid receptor mediated glutamate/GABA imbalance and cerebral abnormalities against cognitive deficit model.
Topics: Animals; Cognitive Dysfunction; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; | 2019 |
Effect of newer anti-epileptic drugs (AEDs) on the cognitive status in pentylenetetrazol induced seizures in a zebrafish model.
Topics: Acetylcholine; Animals; Anticonvulsants; Brain; Brain-Derived Neurotrophic Factor; Cognitive Dysfunc | 2019 |
Newly developed reversible MAO-B inhibitor circumvents the shortcomings of irreversible inhibitors in Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Astrocytes; Cognitive Dysfunction; D-Amino-Acid Oxidase; Enzyme Inhibito | 2019 |
Posterior cingulate γ-aminobutyric acid and glutamate/glutamine are reduced in amnestic mild cognitive impairment and are unrelated to amyloid deposition and apolipoprotein E genotype.
Topics: Aged; Aged, 80 and over; Amyloid beta-Peptides; Apolipoproteins E; Cognitive Dysfunction; Female; ga | 2015 |
Increased GABA concentrations in type 2 diabetes mellitus are related to lower cognitive functioning.
Topics: Aged; Blood Glucose; Case-Control Studies; Cognition; Cognitive Dysfunction; Diabetes Mellitus, Type | 2016 |
A case of refractory seizure with cognitive impairment due to anti-GABA encephalitis.
Topics: Cognitive Dysfunction; Encephalitis; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Seizures | 2016 |
Glutamate-glutamine and GABA in brain of normal aged and patients with cognitive impairment.
Topics: Adult; Aged; Aging; Alzheimer Disease; Analysis of Variance; Case-Control Studies; Cognitive Dysfunc | 2017 |
Carvacrol after status epilepticus (SE) prevents recurrent SE, early seizures, cell death, and cognitive decline.
Topics: Animals; Cell Death; Cognitive Dysfunction; Cymenes; Disease Models, Animal; Electric Stimulation; E | 2017 |