gamma-aminobutyric acid has been researched along with Cirrhosis, Liver in 22 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "With multiple problems emerging from premature termination in mind, the results suggested an acceptable safety profile and favorable effect of pregabalin in reducing muscle cramps compared to placebo in cirrhotic patients." | 9.51 | Efficacy and Safety of Pregabalin for Muscle Cramps in Liver Cirrhosis: A Double-Blind Randomized Controlled Trial. ( Ahn, S; Choi, K; Hong, YH; Joo, SK; Jung, YJ; Kim, W; Lee, DH; Sohn, SY, 2022) |
| "Muscle cramp is possibly related to peripheral nerve hyperexcitability (PNH), and one of the most debilitating symptoms frequently encountered in patients with liver cirrhosis." | 7.11 | Efficacy and Safety of Pregabalin for Muscle Cramps in Liver Cirrhosis: A Double-Blind Randomized Controlled Trial. ( Ahn, S; Choi, K; Hong, YH; Joo, SK; Jung, YJ; Kim, W; Lee, DH; Sohn, SY, 2022) |
| "With multiple problems emerging from premature termination in mind, the results suggested an acceptable safety profile and favorable effect of pregabalin in reducing muscle cramps compared to placebo in cirrhotic patients." | 5.51 | Efficacy and Safety of Pregabalin for Muscle Cramps in Liver Cirrhosis: A Double-Blind Randomized Controlled Trial. ( Ahn, S; Choi, K; Hong, YH; Joo, SK; Jung, YJ; Kim, W; Lee, DH; Sohn, SY, 2022) |
| "Dilutional hyponatremia due to increased plasma arginine vasopressin (AVP) is associated with liver cirrhosis." | 4.31 | Effects of bile duct ligation on the inhibitory control of supraoptic vasopressin neurons. ( Aikins, AO; Cunningham, JT; Farmer, GE; Little, JT, 2023) |
| "Muscle cramp is possibly related to peripheral nerve hyperexcitability (PNH), and one of the most debilitating symptoms frequently encountered in patients with liver cirrhosis." | 3.11 | Efficacy and Safety of Pregabalin for Muscle Cramps in Liver Cirrhosis: A Double-Blind Randomized Controlled Trial. ( Ahn, S; Choi, K; Hong, YH; Joo, SK; Jung, YJ; Kim, W; Lee, DH; Sohn, SY, 2022) |
| "Neuropathology of hepatic encephalopathy (HE) in cirrhosis is primarily astroglial in nature characterized by Alzheimer type 2 astrocytosis together with activation of microglia indicative of neuroinflammation." | 2.61 | Hepatic Encephalopathy in Cirrhosis: Pathology and Pathophysiology. ( Butterworth, RF, 2019) |
| "Pain management in patients with liver cirrhosis is a real challenge and is often inadequate due to a lack of therapeutic efficacy or the high incidence of adverse effects." | 2.50 | [Pain management in patients with liver cirrhosis]. ( Moreno, LA; Ojeda, A, 2014) |
| "Hepatic encephalopathy is a neuropsychiatric complication of liver cirrhosis the symptoms of which may vary from imperceptible to severe, invaliding, and even lethal." | 2.50 | Concise review of current concepts on nomenclature and pathophysiology of hepatic encephalopathy. ( Liakina, V; Savlan, I; Valantinas, J, 2014) |
| "Minimal hepatic encephalopathy is also important because of its tendency to impair patients' cognitive functions and quality of life." | 2.50 | Concise review of current concepts on nomenclature and pathophysiology of hepatic encephalopathy. ( Liakina, V; Savlan, I; Valantinas, J, 2014) |
| "Hepatic encephalopathy is a medical phenomenon that is described as a neuropsychiatric manifestation of chronic or acute liver disease that is characterized by psychomotor, intellectual and cognitive abnormalities with emotional/affective and behavioral disturbances." | 2.49 | Current pathogenetic aspects of hepatic encephalopathy and noncirrhotic hyperammonemic encephalopathy. ( Cichoż-Lach, H; Michalak, A, 2013) |
| "The treatment of hepatic encephalopathy is predominantly an empirical approach because the process pathogenesis of this syndrome is uncertain." | 2.39 | Treatment of hepatic encephalopathy in patients with cirrhosis of the liver. ( Ferenci, P, 1996) |
| "Hepatic encephalopathy is a neuropsyquiatric syndrome associated to multifactorial metabolic disruptions." | 2.38 | [Pathogenesis of portal systemic encephalopathy]. ( Barragán, RF; García Compeán, D; Valadez Castillo, R, 1990) |
| "A patient with hepatic cirrhosis due to Alpers disease is described who had a significantly raised plasma alanine aminotransferase (ALT) activity of 247 U/L which returned to normal (18 U/L) shortly after commencing treatment with the anticonvulsant drug, vigabatrin." | 1.30 | Suppression of elevated alanine aminotransferase activity in liver disease by vigabatrin. ( Coakley, J; Sekaninova, S; Williams, A, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (18.18) | 18.7374 |
| 1990's | 7 (31.82) | 18.2507 |
| 2000's | 1 (4.55) | 29.6817 |
| 2010's | 6 (27.27) | 24.3611 |
| 2020's | 4 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Ahn, S | 1 |
| Hong, YH | 1 |
| Lee, DH | 1 |
| Joo, SK | 1 |
| Jung, YJ | 1 |
| Sohn, SY | 1 |
| Choi, K | 1 |
| Kim, W | 1 |
| Lin, S | 1 |
| Qi, R | 1 |
| Lin, X | 1 |
| Chen, S | 1 |
| Zhang, L | 1 |
| Qiu, Y | 1 |
| Aikins, AO | 1 |
| Farmer, GE | 1 |
| Little, JT | 1 |
| Cunningham, JT | 1 |
| Jaffe, A | 1 |
| Lim, JK | 1 |
| Jakab, SS | 1 |
| Butterworth, RF | 2 |
| Ojeda, A | 1 |
| Moreno, LA | 1 |
| Dwyer, JP | 1 |
| Jayasekera, C | 1 |
| Nicoll, A | 1 |
| Savlan, I | 1 |
| Liakina, V | 1 |
| Valantinas, J | 1 |
| García Compeán, D | 1 |
| Valadez Castillo, R | 1 |
| Barragán, RF | 1 |
| Palomero-Gallagher, N | 1 |
| Bidmon, HJ | 1 |
| Cremer, M | 1 |
| Schleicher, A | 1 |
| Kircheis, G | 1 |
| Reifenberger, G | 1 |
| Kostopoulos, G | 1 |
| Häussinger, D | 1 |
| Zilles, K | 1 |
| Leke, R | 1 |
| Bak, LK | 1 |
| Iversen, P | 1 |
| Sørensen, M | 1 |
| Keiding, S | 1 |
| Vilstrup, H | 1 |
| Ott, P | 1 |
| Portela, LV | 1 |
| Schousboe, A | 1 |
| Waagepetersen, HS | 1 |
| Cichoż-Lach, H | 1 |
| Michalak, A | 1 |
| Ferenci, P | 1 |
| Williams, A | 1 |
| Sekaninova, S | 1 |
| Coakley, J | 1 |
| Pezzuoli, G | 1 |
| Spina, GP | 1 |
| Vassanelli, P | 1 |
| Yoshida, S | 1 |
| Kakegawa, T | 1 |
| Mizote, H | 1 |
| Löscher, W | 2 |
| Kretz, FJ | 2 |
| Karavias, T | 1 |
| Dillinger, U | 2 |
| Thirlby, RC | 1 |
| Fenster, LF | 1 |
| Coatsworth, JJ | 1 |
| Petty, F | 1 |
| Levy, LJ | 1 |
| Losowsky, MS | 1 |
| Lavoie, J | 1 |
| Giguère, JF | 1 |
| Layrargues, GP | 1 |
| Van Leuven, F | 1 |
| Weyne, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Double-blinded, Placebo-controlled Study Evaluating the Efficacy and Safety of 6-week Treatment of Pregabalin Against Frequent Muscle Cramp in Patients With Liver Cirrhosis[NCT01271660] | Phase 3 | 60 participants (Actual) | Interventional | 2011-07-31 | Completed | ||
| A Multicenter, Prospective, Randomized Controlled Study to Explore the Efficacy and Safety of Fecal Microbiota Transplantation With Different Bacterial Doses in the Treatment of Recurrent Hepatic Encephalopathy[NCT05669651] | 100 participants (Anticipated) | Interventional | 2022-12-01 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for gamma-aminobutyric acid and Cirrhosis, Liver
| Article | Year |
|---|---|
Pathophysiology of Hepatic Encephalopathy.
Topics: Ammonia; Animals; Astrocytes; Diabetes Complications; gamma-Aminobutyric Acid; Gastrointestinal Micr | 2020 |
Hepatic Encephalopathy in Cirrhosis: Pathology and Pathophysiology.
Topics: Ammonia; Basal Ganglia; Cerebellum; gamma-Aminobutyric Acid; Hepatic Encephalopathy; Humans; Inflamm | 2019 |
[Pain management in patients with liver cirrhosis].
Topics: Acetaminophen; Amines; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Combined Modality Therap | 2014 |
Analgesia for the cirrhotic patient: a literature review and recommendations.
Topics: Acetaminophen; Amines; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Anti | 2014 |
Concise review of current concepts on nomenclature and pathophysiology of hepatic encephalopathy.
Topics: Ammonia; Cognition; gamma-Aminobutyric Acid; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Mangan | 2014 |
[Pathogenesis of portal systemic encephalopathy].
Topics: Amino Acids; Ammonia; Animals; Fatty Acids; gamma-Aminobutyric Acid; Hepatic Encephalopathy; Humans; | 1990 |
Current pathogenetic aspects of hepatic encephalopathy and noncirrhotic hyperammonemic encephalopathy.
Topics: Ammonia; Animals; Blood-Brain Barrier; Brain; Brain Edema; gamma-Aminobutyric Acid; Hepatic Encephal | 2013 |
Treatment of hepatic encephalopathy in patients with cirrhosis of the liver.
Topics: Amino Acids, Branched-Chain; Ammonia; Clinical Trials as Topic; gamma-Aminobutyric Acid; Hepatic Enc | 1996 |
1 trial available for gamma-aminobutyric acid and Cirrhosis, Liver
| Article | Year |
|---|---|
Efficacy and Safety of Pregabalin for Muscle Cramps in Liver Cirrhosis: A Double-Blind Randomized Controlled Trial.
Topics: Analgesics; Double-Blind Method; gamma-Aminobutyric Acid; Humans; Liver Cirrhosis; Muscle Cramp; Pre | 2022 |
13 other studies available for gamma-aminobutyric acid and Cirrhosis, Liver
| Article | Year |
|---|---|
Association Between MRI-Assessed Patterns of Connectome Gradient and Gene-Expression Profiles in Two Independent Patient Cohorts With Hepatitis B Virus-Related Cirrhosis.
Topics: Brain; Connectome; gamma-Aminobutyric Acid; Hepatitis B virus; Humans; Liver Cirrhosis; Magnetic Res | 2023 |
Effects of bile duct ligation on the inhibitory control of supraoptic vasopressin neurons.
Topics: Animals; Arginine Vasopressin; Bile Ducts; Chlorides; gamma-Aminobutyric Acid; Green Fluorescent Pro | 2023 |
Neurotransmitter receptor imbalances in motor cortex and basal ganglia in hepatic encephalopathy.
Topics: Acetylcholine; Adenosine; Adult; Aged; Autoradiography; Basal Ganglia; Binding Sites; Case-Control S | 2009 |
Synthesis of neurotransmitter GABA via the neuronal tricarboxylic acid cycle is elevated in rats with liver cirrhosis consistent with a high GABAergic tone in chronic hepatic encephalopathy.
Topics: Acetates; Ammonia; Animals; Astrocytes; Brain Chemistry; Chromatography, High Pressure Liquid; Chron | 2011 |
Suppression of elevated alanine aminotransferase activity in liver disease by vigabatrin.
Topics: Alanine Transaminase; Anticonvulsants; Diffuse Cerebral Sclerosis of Schilder; Enzyme Inhibitors; Fa | 1998 |
[Current aspects of the surgery of portal hypertension (PH)].
Topics: Animals; Brain; Brain Diseases; Catecholamines; Enzymes; Esophageal and Gastric Varices; gamma-Amino | 1975 |
[Oral supplementation of branched-chain amino acids in patients with hepatic failure].
Topics: Amino Acids, Branched-Chain; Enteral Nutrition; gamma-Aminobutyric Acid; Hepatic Encephalopathy; Hum | 1991 |
Marked increases of plasma gamma-aminobutyric acid concentrations in cirrhotic patients with portacaval shunts are not associated with alterations of cerebral functions.
Topics: Electroencephalography; Esophageal and Gastric Varices; Female; gamma-Aminobutyric Acid; Gastrointes | 1991 |
[The blood level of gamma-aminobutyric acid in patients with liver cirrhosis and portacaval anastomosis].
Topics: gamma-Aminobutyric Acid; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Portacaval Shunt, Surgical | 1991 |
Reversal of chronic hepatic encephalopathy by colonic exclusion: poor correlation with blood GABA levels.
Topics: Ammonia; Chronic Disease; Electroencephalography; Female; gamma-Aminobutyric Acid; Hepatic Encephalo | 1990 |
Plasma gamma aminobutyric acid concentrations provide evidence of different mechanisms in the pathogenesis of hepatic encephalopathy in acute and chronic liver disease.
Topics: Acute Disease; Adult; Chronic Disease; Delta Rhythm; Female; gamma-Aminobutyric Acid; Hepatic Enceph | 1989 |
Amino acid changes in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy.
Topics: Aged; Amino Acids; Aspartic Acid; Brain Chemistry; Chromatography, High Pressure Liquid; Female; gam | 1987 |
Proceedings: Ammonia and amino acids in the brain of the rat with chronic hepatic failure.
Topics: Amino Acids; Ammonia; Animals; Aspartic Acid; Brain; Carbon Tetrachloride Poisoning; Chronic Disease | 1974 |