gamma-aminobutyric acid has been researched along with Cholestasis in 8 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
Cholestasis: Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EXTRAHEPATIC CHOLESTASIS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pruritus is defined as the second order of nociception, the first being pain; thus, there is a rationale to study gabapentin, a drug that increases the threshold to experience nociception." | 9.12 | Gabapentin in patients with the pruritus of cholestasis: a double-blind, randomized, placebo-controlled trial. ( Bergasa, NV; Engler, D; Ginsburg, IH; McGee, M, 2006) |
| "Combined spinal administration of gabapentin and low doses of morphine significantly reduces pain-related behaviors in this acute rat pancreatitis model, whereas these agents were ineffective when used alone in this dose range." | 7.72 | Intrathecal gabapentin enhances the analgesic effects of subtherapeutic dose morphine in a rat experimental pancreatitis model. ( Lu, Y; Smiley, MM; Vera-Portocarrero, LP; Westlund, KN; Zidan, A, 2004) |
| " In this study, intrathecal gabapentin, which by itself is ineffective when administered spinally, was combined with low-dose morphine and tested in an acute bradykinin-induced pancreatitis model in rats." | 7.72 | Intrathecal gabapentin enhances the analgesic effects of subtherapeutic dose morphine in a rat experimental pancreatitis model. ( Lu, Y; Smiley, MM; Vera-Portocarrero, LP; Westlund, KN; Zidan, A, 2004) |
| "Gabapentin was associated with an increase in mean HSA, in contrast to the placebo, which was associated with a decrease." | 6.72 | Gabapentin in patients with the pruritus of cholestasis: a double-blind, randomized, placebo-controlled trial. ( Bergasa, NV; Engler, D; Ginsburg, IH; McGee, M, 2006) |
| "Pruritus is defined as the second order of nociception, the first being pain; thus, there is a rationale to study gabapentin, a drug that increases the threshold to experience nociception." | 6.72 | Gabapentin in patients with the pruritus of cholestasis: a double-blind, randomized, placebo-controlled trial. ( Bergasa, NV; Engler, D; Ginsburg, IH; McGee, M, 2006) |
| "Morphine sulfate has long been used for analgesia, but clinical applications can be limited by side effects, tolerance, and potential for addiction at therapeutic doses." | 5.32 | Intrathecal gabapentin enhances the analgesic effects of subtherapeutic dose morphine in a rat experimental pancreatitis model. ( Lu, Y; Smiley, MM; Vera-Portocarrero, LP; Westlund, KN; Zidan, A, 2004) |
| "Pruritus is defined as the second order of nociception, the first being pain; thus, there is a rationale to study gabapentin, a drug that increases the threshold to experience nociception." | 5.12 | Gabapentin in patients with the pruritus of cholestasis: a double-blind, randomized, placebo-controlled trial. ( Bergasa, NV; Engler, D; Ginsburg, IH; McGee, M, 2006) |
| "Combined spinal administration of gabapentin and low doses of morphine significantly reduces pain-related behaviors in this acute rat pancreatitis model, whereas these agents were ineffective when used alone in this dose range." | 3.72 | Intrathecal gabapentin enhances the analgesic effects of subtherapeutic dose morphine in a rat experimental pancreatitis model. ( Lu, Y; Smiley, MM; Vera-Portocarrero, LP; Westlund, KN; Zidan, A, 2004) |
| " In this study, intrathecal gabapentin, which by itself is ineffective when administered spinally, was combined with low-dose morphine and tested in an acute bradykinin-induced pancreatitis model in rats." | 3.72 | Intrathecal gabapentin enhances the analgesic effects of subtherapeutic dose morphine in a rat experimental pancreatitis model. ( Lu, Y; Smiley, MM; Vera-Portocarrero, LP; Westlund, KN; Zidan, A, 2004) |
| "Gabapentin was associated with an increase in mean HSA, in contrast to the placebo, which was associated with a decrease." | 2.72 | Gabapentin in patients with the pruritus of cholestasis: a double-blind, randomized, placebo-controlled trial. ( Bergasa, NV; Engler, D; Ginsburg, IH; McGee, M, 2006) |
| "Pruritus is defined as the second order of nociception, the first being pain; thus, there is a rationale to study gabapentin, a drug that increases the threshold to experience nociception." | 2.72 | Gabapentin in patients with the pruritus of cholestasis: a double-blind, randomized, placebo-controlled trial. ( Bergasa, NV; Engler, D; Ginsburg, IH; McGee, M, 2006) |
| "Morphine sulfate has long been used for analgesia, but clinical applications can be limited by side effects, tolerance, and potential for addiction at therapeutic doses." | 1.32 | Intrathecal gabapentin enhances the analgesic effects of subtherapeutic dose morphine in a rat experimental pancreatitis model. ( Lu, Y; Smiley, MM; Vera-Portocarrero, LP; Westlund, KN; Zidan, A, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (75.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pongcharoen, P | 1 |
| Fleischer, AB | 1 |
| Anand, S | 1 |
| Richardson, CE | 1 |
| Williams, DW | 1 |
| Kingham, JG | 1 |
| Smiley, MM | 1 |
| Lu, Y | 1 |
| Vera-Portocarrero, LP | 1 |
| Zidan, A | 1 |
| Westlund, KN | 1 |
| Prommer, E | 1 |
| Marzioni, M | 1 |
| Fava, G | 1 |
| Benedetti, A | 1 |
| Bergasa, NV | 1 |
| McGee, M | 1 |
| Ginsburg, IH | 1 |
| Engler, D | 1 |
| Crespo Pérez, L | 1 |
| Moreira Vicente, V | 1 |
| Manzano Fernández, R | 1 |
| García Aguilera, XA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Study of Gabapentin for the Pruritus of Cholestasis[NCT00058890] | Phase 3 | 15 participants (Actual) | Interventional | 2000-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for gamma-aminobutyric acid and Cholestasis
| Article | Year |
|---|---|
Itch Management: Systemic Agents.
Topics: Amines; Analgesics; Analgesics, Opioid; Anion Exchange Resins; Antidepressive Agents; Aprepitant; Ch | 2016 |
Gabapentin for pruritus in palliative care.
Topics: Amines; Analgesics, Opioid; Burns; Cholestasis; Cyclohexanecarboxylic Acids; Dermatologic Agents; Ga | 2013 |
Nervous and Neuroendocrine regulation of the pathophysiology of cholestasis and of biliary carcinogenesis.
Topics: Animals; Bile Duct Neoplasms; Bile Ducts; Cell Proliferation; Cholestasis; gamma-Aminobutyric Acid; | 2006 |
1 trial available for gamma-aminobutyric acid and Cholestasis
| Article | Year |
|---|---|
Gabapentin in patients with the pruritus of cholestasis: a double-blind, randomized, placebo-controlled trial.
Topics: Adult; Amines; Analgesics; Cholestasis; Chronic Disease; Cyclohexanecarboxylic Acids; Double-Blind M | 2006 |
4 other studies available for gamma-aminobutyric acid and Cholestasis
| Article | Year |
|---|---|
Gabapentin induced cholestasis.
Topics: Acetates; Amines; Anticonvulsants; Cholestasis; Cyclohexanecarboxylic Acids; Diabetic Neuropathies; | 2002 |
Intrathecal gabapentin enhances the analgesic effects of subtherapeutic dose morphine in a rat experimental pancreatitis model.
Topics: Acetates; Acute Disease; Amines; Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Bradykin | 2004 |
Re: Pruritus in patients with advanced cancer.
Topics: Cholestasis; Cholestyramine Resin; GABA Agonists; gamma-Aminobutyric Acid; Humans; Narcotic Antagoni | 2005 |
[Cholestasis associated with pregabalin treatment].
Topics: Analgesics; Cholestasis; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Pregabalin | 2008 |