gamma-aminobutyric acid has been researched along with Chemical and Drug Induced Liver Injury in 27 studies
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.
gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In rats with hepatic encephalopathy, the concentrations of GABA, glutamate and taurine were decreased in the cerebral cortex, the hippocampus and the striatum, whereas those of aspartate and glycine were unchanged or increased." | 5.28 | Hepatic encephalopathy in thioacetamide-induced acute liver failure in rats: characterization of an improved model and study of amino acid-ergic neurotransmission. ( Ebner, J; Ferenci, P; Hörtnagl, H; Lassmann, H; Pifl, C; Roth, E; Yurdaydin, C; Zimmermann, C, 1989) |
| " More specifically, vigabatrin, which is a very useful and well tolerated new antiepileptic drug for refractory partial epilepsy, should be started at a low dosage of 0." | 4.79 | The new anticonvulsant drugs. Implications for avoidance of adverse effects. ( Krämer, G; Schmidt, D, 1994) |
| "The mechanism of prolongation of sleeping (anesthesia) time after phenobarbital (PB) treatment was assessed in mice with ethionine (ET)-induced liver disorders (ET-treated group)." | 3.69 | Sleeping time after phenobarbital treatment and the brain levels of gamma-aminobutyric acid and phenobarbital at the regaining of righting response point in ethionine-induced liver-disordered mice. ( Kawai, Y; Noguchi, M, 1996) |
| " Finally, gabapentin is a very safe add-on medication." | 2.39 | The new anticonvulsant drugs. Implications for avoidance of adverse effects. ( Krämer, G; Schmidt, D, 1994) |
| " More specifically, vigabatrin, which is a very useful and well tolerated new antiepileptic drug for refractory partial epilepsy, should be started at a low dosage of 0." | 2.39 | The new anticonvulsant drugs. Implications for avoidance of adverse effects. ( Krämer, G; Schmidt, D, 1994) |
| "Gabapentin is an anticonvulsant medication used as an adjuvant in the treatment of neuropathic pain; few cases have been reported in which it causes acute liver injury." | 1.62 | [Hepatotoxicity probably associated with gabapentin]. ( Contreras-Mota, M; Rosales-Cortés, V, 2021) |
| "To report a case of acute elevation of hepatic enzyme levels as a probable adverse reaction associated with pregabalin." | 1.37 | Pregabalin-induced hepatotoxicity. ( Junyent, TT; Pellicer, MJ; Sendra, JM, 2011) |
| " The low pregabalin dosage and the short time to elevation of liver enzyme levels suggest an idiosyncratic reaction." | 1.37 | Pregabalin-induced hepatotoxicity. ( Junyent, TT; Pellicer, MJ; Sendra, JM, 2011) |
| "In rats with hepatic encephalopathy, the concentrations of GABA, glutamate and taurine were decreased in the cerebral cortex, the hippocampus and the striatum, whereas those of aspartate and glycine were unchanged or increased." | 1.28 | Hepatic encephalopathy in thioacetamide-induced acute liver failure in rats: characterization of an improved model and study of amino acid-ergic neurotransmission. ( Ebner, J; Ferenci, P; Hörtnagl, H; Lassmann, H; Pifl, C; Roth, E; Yurdaydin, C; Zimmermann, C, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (22.22) | 18.7374 |
| 1990's | 3 (11.11) | 18.2507 |
| 2000's | 7 (25.93) | 29.6817 |
| 2010's | 9 (33.33) | 24.3611 |
| 2020's | 2 (7.41) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, Z | 2 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 1 |
| Park, NH | 1 |
| Lee, SJ | 1 |
| Mechesso, AF | 1 |
| Boby, N | 1 |
| Yixian, Q | 1 |
| Yoon, WK | 1 |
| Lee, SP | 1 |
| Lee, JS | 1 |
| Park, SC | 1 |
| Contreras-Mota, M | 1 |
| Rosales-Cortés, V | 1 |
| Yang, H | 1 |
| Xing, R | 1 |
| Liu, S | 1 |
| Yu, H | 1 |
| Li, P | 1 |
| Wang, S | 2 |
| Sui, S | 1 |
| Peng, C | 1 |
| Liu, J | 1 |
| Luo, D | 1 |
| Fan, X | 1 |
| Liu, C | 2 |
| Lu, WY | 2 |
| Mohd Ali, N | 1 |
| Mohd Yusof, H | 1 |
| Long, K | 1 |
| Yeap, SK | 1 |
| Ho, WY | 1 |
| Beh, BK | 1 |
| Koh, SP | 1 |
| Abdullah, MP | 1 |
| Alitheen, NB | 1 |
| Shilpa, J | 1 |
| Anitha, M | 1 |
| Paulose, CS | 1 |
| Georges, P | 1 |
| Schürholz, T | 1 |
| Xiang, YY | 1 |
| Zhu, J | 1 |
| Yi, F | 1 |
| Li, J | 1 |
| Einarsdottir, S | 1 |
| Björnsson, E | 1 |
| Crespo Pérez, L | 1 |
| Moreira Vicente, V | 1 |
| Cano Ruiz, A | 1 |
| Gobernado Serrano, JM | 1 |
| Cobo Ibañez, N | 1 |
| Milicua Salamero, JM | 1 |
| Sendra, JM | 1 |
| Junyent, TT | 1 |
| Pellicer, MJ | 1 |
| Hauben, M | 1 |
| Bureau, C | 1 |
| Poirson, H | 1 |
| Péron, JM | 1 |
| Vinel, JP | 1 |
| Yogeeswari, P | 1 |
| Sriram, D | 1 |
| Thirumurugan, R | 1 |
| Raghavendran, JV | 1 |
| Sudhan, K | 1 |
| Pavana, RK | 1 |
| Stables, J | 1 |
| Himmerich, H | 1 |
| Nickel, T | 1 |
| Dalal, MA | 1 |
| Müller, MB | 1 |
| Strolin Benedetti, M | 1 |
| Rumigny, JF | 1 |
| Dostert, P | 1 |
| Nau, H | 1 |
| Löscher, W | 1 |
| Schmidt, D | 1 |
| Krämer, G | 1 |
| Noguchi, M | 1 |
| Kawai, Y | 1 |
| Lasso-de-la-Vega, MC | 1 |
| Zapater, P | 1 |
| Such, J | 1 |
| Pérez-Mateo, M | 1 |
| Horga, JF | 1 |
| Wang, F | 1 |
| Niu, Z | 1 |
| Li, ZM | 1 |
| Zimmermann, C | 1 |
| Ferenci, P | 2 |
| Pifl, C | 1 |
| Yurdaydin, C | 1 |
| Ebner, J | 2 |
| Lassmann, H | 1 |
| Roth, E | 1 |
| Hörtnagl, H | 1 |
| Crawford, P | 1 |
| Chadwick, D | 1 |
| Munoz, SJ | 1 |
| Fariello, R | 1 |
| Maddrey, WC | 1 |
| Stehle, T | 1 |
| Schmid, R | 1 |
| Häussinger, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Protective Role of Preoperative Stimulation of the Distal Limb of the Ileostomy Loop With GABA Before Ileostomy Closure[NCT05905393] | Phase 3 | 80 participants (Anticipated) | Interventional | 2023-06-30 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for gamma-aminobutyric acid and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
[Anticonvulsant hypersensitivity syndrome: an entity to be remembered].
Topics: Adolescent; Amines; Anemia, Hemolytic; Anticonvulsants; Astrocytoma; Brain Neoplasms; Carbamazepine; | 2009 |
[Mechanisms of action and biochemical toxicology of valproic acid].
Topics: 4-Aminobutyrate Transaminase; Aldehyde Oxidoreductases; Ammonia; Animals; Anticonvulsants; Aspartic | 1984 |
The new anticonvulsant drugs. Implications for avoidance of adverse effects.
Topics: Abnormalities, Drug-Induced; Anemia, Aplastic; Anticonvulsants; Chemical and Drug Induced Liver Inju | 1994 |
1 trial available for gamma-aminobutyric acid and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
A comparative study of progabide, valproate, and placebo as add-on therapy in patients with refractory epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Chemical and Drug Induced Liver Injury; Drug Interactions; Drug | 1986 |
23 other studies available for gamma-aminobutyric acid and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Hepatoprotective effects of gamma-aminobutyric acid-enriched fermented Hovenia dulcis extract on ethanol-induced liver injury in mice.
Topics: Animals; Chemical and Drug Induced Liver Injury; Chromatography; Disease Models, Animal; Ethanol; Fe | 2020 |
[Hepatotoxicity probably associated with gabapentin].
Topics: Amines; Analgesics; Chemical and Drug Induced Liver Injury; Cyclohexanecarboxylic Acids; Gabapentin; | 2021 |
Rescuing fluoride-induced damages in liver with gamma aminobutyric acid.
Topics: Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Fluoride Poisoning; gamma-Aminobutyric A | 2017 |
Protective roles of hepatic gamma-aminobutyric acid signaling in acute ethanol exposure-induced liver injury.
Topics: Acute Disease; Adult; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Disease Models, An | 2018 |
Antioxidant and hepatoprotective effect of aqueous extract of germinated and fermented mung bean on ethanol-mediated liver damage.
Topics: Animals; Antioxidants; Central Nervous System Depressants; Chemical and Drug Induced Liver Injury; E | 2013 |
Increased neuronal survival in the brainstem during liver injury: role of γ-aminobutyric acid and serotonin chitosan nanoparticles.
Topics: Animals; bcl-2-Associated X Protein; Biocompatible Materials; Brain Stem; Caspase 8; Cell Survival; | 2013 |
[Intensive care quiz--get the diagnosis!].
Topics: Analgesics; Chemical and Drug Induced Liver Injury; Critical Care; Dyspnea; Echocardiography, Transe | 2013 |
Gabapentin and pregabalin: hepatic and haematological toxicity.
Topics: Amines; Analgesics; Chemical and Drug Induced Liver Injury; Cyclohexanecarboxylic Acids; France; Gab | 2014 |
Protective roles of hepatic GABA signaling in acute liver injury of rats.
Topics: Animals; Baclofen; Chemical and Drug Induced Liver Injury; GABA-A Receptor Agonists; GABA-B Receptor | 2017 |
Pregabalin as a probable cause of acute liver injury.
Topics: Acute Disease; Analgesics; Chemical and Drug Induced Liver Injury; gamma-Aminobutyric Acid; Herpes Z | 2008 |
Pregabalin-induced hepatotoxicity.
Topics: Analgesics; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; gamma-Aminobut | 2011 |
Re: Lasso-de-la-Vega et al. gabapentin as a probable cause of hepatotoxicity and eosinophilia.
Topics: Acetates; Amines; Analgesics; Anti-Infective Agents; Chemical and Drug Induced Liver Injury; Ciprofl | 2002 |
[Gabapentine-induced acute hepatitis].
Topics: Acetates; Acute Disease; Amines; Anticonvulsants; Chemical and Drug Induced Liver Injury; Cyclohexan | 2003 |
Discovery of N-(2,6-dimethylphenyl)-substituted semicarbazones as anticonvulsants: hybrid pharmacophore-based design.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Benzamides; Chemical and Drug Induced Liver | 2005 |
[Gabapentin treatment in a female patient with panic disorder and adverse effects under carbamazepine during benzodiazepine withdrawal].
Topics: Aged; Alprazolam; Amines; Antimanic Agents; Benzodiazepines; Carbamazepine; Chemical and Drug Induce | 2007 |
Valproic acid and metabolites: pharmacological and toxicological studies.
Topics: Abnormalities, Drug-Induced; Animals; Brain; Chemical and Drug Induced Liver Injury; Chemical Phenom | 1984 |
Sleeping time after phenobarbital treatment and the brain levels of gamma-aminobutyric acid and phenobarbital at the regaining of righting response point in ethionine-induced liver-disordered mice.
Topics: Anesthesia; Anesthesia Recovery Period; Animals; Brain Chemistry; Carcinogens; Chemical and Drug Ind | 1996 |
Gabapentin-associated hepatotoxicity.
Topics: Acetates; Amines; Analgesics; Chemical and Drug Induced Liver Injury; Cyclohexanecarboxylic Acids; G | 2001 |
Plasma gamma-aminobutyric acid in experimental fulminant hepatic failure of rats and its diagnostic value in hepatic encephalopathy.
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Galactosamine; gamma-Aminobut | 1990 |
Hepatic encephalopathy in thioacetamide-induced acute liver failure in rats: characterization of an improved model and study of amino acid-ergic neurotransmission.
Topics: Acetamides; Animals; Brain; Chemical and Drug Induced Liver Injury; gamma-Aminobutyric Acid; Glutama | 1989 |
Submassive hepatic necrosis associated with the use of progabide: a GABA receptor agonist.
Topics: Adult; Anticonvulsants; Chemical and Drug Induced Liver Injury; Female; gamma-Aminobutyric Acid; Hum | 1988 |
Uptake and catabolism of gamma-aminobutyric acid by the isolated perfused rat liver.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chromatography, Hig | 1988 |